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Sepsis is a leading cause of global mortality in children, yet definitions for pediatric sepsis are outdated and lack global applicability and validity. In adults, the Sepsis-3 Definition Taskforce queried databases from high-income countries to develop and validate the criteria. The merit of this definition has been widely acknowledged; however, important considerations about less-resourced and more diverse settings pose challenges to its use globally. To improve applicability and relevance globally, the Pediatric Sepsis Definition Taskforce sought to develop a conceptual framework and rationale of the critical aspects and context-specific factors that must be considered for the optimal operationalization of future pediatric sepsis definitions. It is important to address challenges in developing a set of pediatric sepsis criteria which capture manifestations of illnesses with vastly different etiologies and underlying mechanisms. Ideal criteria need to be unambiguous, and capable of adapting to the different contexts in which children with suspected infections are present around the globe. Additionally, criteria need to facilitate early recognition and timely escalation of treatment to prevent progression and limit life-threatening organ dysfunction. To address these challenges, locally adaptable solutions are required, which permit individualized care based on available resources and the pretest probability of sepsis. This should facilitate affordable diagnostics which support risk stratification and prediction of likely treatment responses, and solutions for locally relevant outcome measures. For this purpose, global collaborative databases need to be established, using minimum variable datasets from routinely collected data. In summary, a “Think globally, act locally” approach is required.

On a national basis, nine out of 10 businesses -- over 20 million -- are classified as small. These companies provide two out of three initial job opportunities and it [...]

'The U.S. Small Business Administration has made LowDoc -- a new loan program based on a one-page application form -- available nationwide, making its basic business loan guarantee program more [...]

'Venice is ... a mirror held up to its own shimmering image – the central conceit on which it has evolved.' So writes Mary McCarthy of the city of canals and glassworks. She adds, moving from one companion of Narcissus to another, 'and no word can be spoken in this city that is not an echo of something said before.' My essay takes this last dictum for granted, not merely as an excuse for plagiarism, but as an historical principle too. Venetian images do not begin, they just persist. Even when a discoverable beginning really exists, it is hard to believe that you have really located it.

THE PAGET-SCHROETTER syndrome is identified with the symptomatology of a neurovascular disease of the upper limb, the predominant lesion of which is obstruction of the axillary vein.Among the many causes of shoulder pain the neurovascular syndromes occupy a unique and puzzling position. As the neural and vascular elements of the upper limb pass from the cervical and thoracic regions to converge and proceed into the axilla, they become vulnerable to minor trauma by the firmer supporting structures. Trauma by a cervical rib,1 by a hypertrophied scalenus anticus muscle,2 by a prevenous phrenic nerve,3 by the lower border of the subclavius muscle and the costoclavicular ligament,4 or by the clavicle and first rib5 is a potentiality in 50 to 80% of adults.6The vulnerable elements are the motor, sensory, and autonomic components of the brachial plexus, the axillary artery, and the axillary vein. They are subject to sudden, or continuous,

Bernard Blackstone, The Consecrated Urn: an Interpretation of Keats in Terms of Growth and Form, reviewed by Milton WilsonHarold Bloom, Shelley's Mythmaking, reviewed by Milton WilsonDavid Perkins, The Quest for Permanence: The Symbolism of Wordsworth, Shelley and Keats, reviewed by Milton WilsonBernice Slote, Keats and the Dramatic Principle, reviewed by Milton WilsonEarl R. Wasserman, The Subtler Language: Critical Readings of Neoclassic and Romantic Poems, reviewed by Milton Wilson

Anthony Beal, D.H. Lawrence: Selected Literary Criticism, reviewed by Douglas GrantT.S. Eliot, On Poetry and Poets, reviewed by Douglas GrantF.R. Leavis, D.H. Lawrence: Novelist, reviewed by Douglas GrantJohn Middleton Murry, Love, Freedom, and Society, reviewed by Douglas GrantEdward Nehls, D.H. Lawrence: A Composite Biography, reviewed by Douglas GrantHardin Craig, English Religious Drama of the Middle Ages, reviewed by F.D. HoenigerNeville Roger, Shelley at Work, reviewed by Milton Wilson

Reviews of poetry published in Canada in 1961.