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2. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

Author

Weiner, January, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H, Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arkal, Rao Arjun, Fragiadakis, Gabriela K, Mick, Eran, COMET, Consortium, Calfee, Carolyn S, Erle, David J, Hendrickson, Carolyn M, Kangelaris, Kirsten N, Krummel, Matthew F, Woodruff, Prescott G, Langelier, Charles R, Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, and Heidecker, Bettina

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Coronaviruses, Emerging Infectious Diseases, Human Genome, Clinical Research, Infectious Diseases, Genetics, 2.1 Biological and endogenous factors, 2.5 Research design and methodologies (aetiology), Good Health and Well Being, SARS-CoV-2, COVID-19, Human Leukocyte Antigen&nbsp, intubation, Human Leukocyte Antigen, Clinical sciences, Health services and systems, Public health
Abstract

BackgroundSince the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there has been increasing urgency to identify pathophysiological characteristics leading to severe clinical course in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Human leukocyte antigen alleles (HLA) have been suggested as potential genetic host factors that affect individual immune response to SARS-CoV-2. We sought to evaluate this hypothesis by conducting a multicenter study using HLA sequencing.MethodsWe analyzed the association between COVID-19 severity and HLAs in 435 individuals from Germany (n = 135), Spain (n = 133), Switzerland (n = 20) and the United States (n = 147), who had been enrolled from March 2020 to August 2020. This study included patients older than 18 years, diagnosed with COVID-19 and representing the full spectrum of the disease. Finally, we tested our results by meta-analysing data from prior genome-wide association studies (GWAS).FindingsWe describe a potential association of HLA-C*04:01 with severe clinical course of COVID-19. Carriers of HLA-C*04:01 had twice the risk of intubation when infected with SARS-CoV-2 (risk ratio 1.5 [95% CI 1.1-2.1], odds ratio 3.5 [95% CI 1.9-6.6], adjusted p-value = 0.0074). These findings are based on data from four countries and corroborated by independent results from GWAS. Our findings are biologically plausible, as HLA-C*04:01 has fewer predicted bindings sites for relevant SARS-CoV-2 peptides compared to other HLA alleles.InterpretationHLA-C*04:01 carrier state is associated with severe clinical course in SARS-CoV-2. Our findings suggest that HLA class I alleles have a relevant role in immune defense against SARS-CoV-2.FundingFunded by Roche Sequencing Solutions, Inc.

Published
2021

3. Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

Author

Pan, Hongchao, Peto, Richard, Henao Restrepo, Ana Maria, Preziosi, Marie-Pierre, Sathiyamoorthy, Vasee, Karim, Quarraisha Abdool, Alejandria, Marissa, Hernàndez García, César, Kieny, Marie-Paule, Malekzadeh, Reza, Murthy, Srinivas, Reddy, K. Srinath, Periago, Mirta Roses, Hanna, Pierre Abi, Abutidze, Akaki, Ader, Florence, Al-Bader, Abdullah, Alhasawi, Almonther, Allum, Emma, Al Mawali, Adhra, Alotaibi, Athari, Alvarez- Moreno, Carlos, Appadoo, Sheila, Arts, Derk, Asiri, Abdullah, Aukrust, Pål, Barratt-Due, Andreas, Genetu Bayih, Abebe, Beaumont, Helena, Bellani, Samir, Benassi, Virginia, Bhargava, Balram, Branca, Mattia, Cappel-Porter, Heike, Cerrato, Nery, Cheick Haidara, Fadima, Chow, Ting Soo, Como, Nadia, Eustace, Joe, Gabunia, Tamar, García, Patricia, Godbole, Sheela, Gotuzzo, Eduardo, Griskevicius, Laimonas, Hamra, Rasha, Hassan, Mariam, Hassany, Mohamed, Hutton, David, Irmansyah, Irmansyah, Jancoriene, Ligita, Khamis, Faryal, Kirwan, Jana, Kumar, Suresh, Lennon, Peter, Lopardo, Gustavo, Lydon, Patrick, Magrini, Nicola, Manevska, Suzana, Manuel, Oriol, McGinty, Sybil, Medina, Marco, Mesa Rubio, Maria Lucia, Miranda Montoya, Maria Consuelo, Nel, Jeremy, Nunes, Estevao, Perola, Markus, Portoles, Antonio, Rasmin, Menaldi, Raza, Aun, Rees, Helen, Reges, Paula, Rogers, Chris, Salami, Kolawole, Salvadori, Marina, Sauermann, Mamatha, Sinani, Narvina, Sow, Samba, Sterne, Jonathan AC, Stevanovikj, Milena, Tacconelli, Evelina, Tavares Maltez, Fernando Manuel, Teferi, Mekonnen, Tikkinen, Kari, Trelle, Sven, Tsertsvadze, Tengiz, Zaid, Hala, Røttingen, John-Arne, Swaminathan, Soumya, Ryan, Michael, Gjermeni, Nevila, Meta, Esmeralda, Aguila, Damian, Alonso, Ignacio, Altamirano, Marcos, Alvarez, María, Alzola, Rodrigo, Arce, Veronica, Arribillaga, Patricia, Avila, Rafael, Balbuena, Juan, Barcelona, Laura, Barletta, José, Benedetti, María, Berdiñas, Verónica, Burgui, Julieta, Caimi, Sabrina, Carrillo, Juan, Carrizo, Juan, Castelli, Juan, Cazaux, Alexis, Cervellino, Flavia, Chalco, Angelo, Chediack, Viviana, Cunto, Eleonora, D'Amico, Nicolàs, de Vedia, Lautaro, Delgado, Carolina, Di Pilla, Debora, Díaz, Miguel, Díaz Aguiar, Pablo, Domínguez, Cecilia, Ellero, Leonor, Farina, Javier, Fernàndez, José, Ferreyra, Roxana, Filippi, María, Fogar, Carolina, Frare, Pablo, Giudiche, Celeste, Golikow, Mariana, Gomez, Maria Georgina, Hermida, Laura, Hurtado, Mariano, Jacobo, Mariela, Jaume, Martin, Laplume, Diego, Lescano, María, Lista, Nicolàs, Loiacono, Flavia, López, Ana Belen, Losso, Marcelo, Luna, Cecilia, Lupo, Sergio, Marianelli, Leonardo, Martin, Anabella, Masciottra, Florencia, Mykietiuk, Analía, Orellano, Lorena, Pachioli, Valeria, Padilla, María José, Pallavicini, Cecilia, Patroso, Jazmin, Perez Blanco, Luz, Presas, Jose Louis, Provenzano, Matias, Lavera, Lorena, Reichert, Viviana, Riveros, Florencia, Rodríguez, Alejandra, Rolon, María José, Salvay, Carolina, Simonetta, María, Sisto, Alicia, Themines, Sandra, Tito, Fernando, Toibaro, Javier, Torales, Graciela, Verón, Luciano, Vizzotti, Carla, Egle, Alexander, Greil, Richard, Joannidis, Michael, Altdorfer, Antoine, Belkhir, Leila, Fraipont, Vincent, Hites, Maya, Arruda, Erico, Breda, Giovanni, Colussi, Arthur, Corradi, Miran, Croda, Julio, Duani, Helena, João, Esaú, Machado, Elizabeth, Mello, Fernanda, Miranda Filho, Demócrito, Monteiro, Poliana, Nunes, Ceuci, Pereira Junior, Luiz Carlos, Pinto, Gustavo, Raboni, Sonia, Ramos, Marcelo, Ruffing, Leonardo, Santos, Valdilea, Souza, Tamara, Medeiros, Melissa, Schwarzbold, Alexandre, Ali, Karim, Azher, Tanweer, Bellemare, David, Binnie, Alexandra, Borgia, Sergio, Cavayas, Yiorgos Alexandros, Chagnon, Nicholas, Cheng, Matthew, Cloutier, Eve, Conly, John, Costiniuk, Cecilia, Daneman, Nick, Douglas, James, Downey, Catarina, Duan, Erick, Durand, Medeline, English, Shane, Farjou, George, Fera, Evadiki, Fontela, Patricia, Fowler, Rob, Fralick, Mike, Gamble, David Gregory, Geagea, Anna, Grant, Jennifer, Harrison, Luke, Havey, Thomas, Hoang, Holly, Kelly, Lauren, Keynan, Yoav, Khwaja, Kosar, Klein, Marina, Kolan, Christophe, Kronfli, Nadine, Lamontagne, Francois, Lee, Nelson, Lee, Todd, Lim, Rachel, Lostun, Alexandra, MacIntyre, Erika, Malhamé, Isabelle, Martin-Carrier, Francois, McGuinty, Marlee, Munan, Matthew, O'Neil, Conar, Ovakim, Daniel, Papenburg, Jesse, Parhar, Ken, Parvathy, SeemaNair, Perez-Patrigeon, Santiago, Rishu, Asgar, Rushton, Moira, Scherr, Kim, Schwartz, Kevin, Semret, Makeda, Silverman, Micahel, Singh, Ameeta, Sligl, Wendy, Smith, Stephanie, Somayaji, Ranjani, Tan, Darrell, Tran, Tuong-Vi, Tremblay, Alain, Tsang, Jennifer, Turgeon, Alexis, Vakil, Erik, Weatherald, Jason, Yansouni, Cedric, Zarychanski, Ryan, Aristizabal, Claudia, Bravo, Juan, Caicedo, Monica, Chacón, Julio, Garzón, Diego, Guevara, Fredy, Lozano-Gonzàlez, Silvia, Macareno, Hugo, Montañez-Ayala, Anita, Oñate, Jose, Rojas-Gambasica, Jose, Rosso, Fernando, Saavedra, Carlos, Valderrama, Sandra, Vàquiro-Herrera, Eliana, Varón-Vega, Fabio, Zuluaga, Ivan, Abdel Baki, Amin, Abdelbary, Akram, Abdel-Razek, Wael, Amin, Wagdi, Asem, Noha, Elassal, Gehan, Elshesheny, Marwa, Fathy, Mohamed, Fathy, Naglaa, Fayed, Notaila, Hammam, Ahmed, Hassany, Sahar, Ibrahim, Hamdy, Kamal, Ehab, Masoud, Hossam, Mohamed, Maryam, Mohamed Gouda, Abdullah, Moustafa, Ehab, Okasha, Shaimaa, Rafik, Ahmed, Said, Ahmed, Sedky, Asmaa, Solyman Kabil, Mohamed, Tarek, Sara, Tharwat, Ahmed, Zaky, Samy, Abegaz, Emawayish Tesema, Bekele, Zelalem Mekonnen, Asfaw, Filmona Mekuria, Tegegne, Netsanet Aragaw, Teklemariam, Miheret Fikre, Nigusse, Frehiwot Tamiru, Achalu, Daniel Legesse, Weldegergs, Shewit Tesfagabr, Huluka, Dawit Kebede, Tereda, Addisu Birhanu, Ala-Kokko, Tero, Delany, Jutta, Ekroos, Heikki, Hankkio, Riina, Haukipää, Mia, Hetemäki, Iivo, Holma, Pia, Holmberg, Ville, Horstia, Saana, Jalkanen, Ville, Jämsänen, Toni, Järventie, Juuso, Järvinen, Petrus, Kalliala, Ilkka, Kauma, Heikki, Kilpeläinen, Tuomas, Kreivi, Hanna-Riikka, Kuitunen, Ilari, Lamminmäki, Satu, Mäkinen, Laura, Mäntylä, Jarkko, Mattila, Tiina, Myllärniemi, Marjukka, Niskanen, Joni, Nykänen, Taina, Nyqvist, Miro, Paajanen, Juuso, Partanen, Terhi, Patovirta, Riitta-Liisa, Paukkeri, Erja-Leena, Puusti, Emmi, Renner, Andreas, Reponen, Emma, Risku, Sari, Rosberg, Tuomas, Rutanen, Jarno, Säilä, Petrus, Salonen, Päivi, Sinisalo, Marjatta, Sivenius, Katariina, Tuominen, Susanna, Aboab, Jerone, Alfaiate, Toni, Andrejak, Claire, Andreu, Pascal, Belhadi, Drifa, Benezit, Francois, Botelho-Nevers, Elisabeth, Bouadma, Lila, Bougon, David, Bouiller, Kevin, Bounes, Fanny, Boyer, Alexandre, Bruel, Cédric, Buffet, Alexandre, Burdet, Charles, Cazanave, Charles, Chabertier, Cyrille, Clere-Jehl, Rapahel, Costagliola, Dominique, Courjon, Johan-Victor, Crockett, Flora, Danion, Francois, Dechanet, Aline, Dellamonica, Jean, Delmas, Christelle, Diallo, Alpha, Djossou, Felix, Dubost, Clement, Dupont, Axelle, Epaulard, Olivier, Faure, Emmmanuel, Faure, Karine, Fayol, Antoine, Figueiredo, Samy, Fougerou, Claire, Gaborit, Benjamin, Gaci, Rostane, Gagneux-Brunon, Amandine, Gallien, Sebastien, Garot, D, Goehringer, Francois, Gruson, Didier, Hinschberger, Olivier, Hulot, Jean-Sebastien, Jaureguiberry, Stephane, Jean-Michel, Vanessa, Kerneis, Solen, Kimmoun, Antoine, Klouche, Kada, Lachatre, Marie, Lacombe, Karine, Laine, Fabrice, Lanoix, Jean Philippe, Laribi, Samira, Launay, Odile, Laviolle, Bruno, Le Moing, Vincent, Le Pavec, Jerome, Lebeaux, David, Leroy, Sylvie, Lescure, Xavier, Livrozet, Marine, Makinson, Alain, Malvy, Denis, Marquette, Charles-Hugo, Martin-Blondel, Guillaume, Mayaux, Julien, Mekontso Dessap, Armand, Mentre, France, Mercier, Noemie, Meziani, Ferhat, Molina, Jean Michel, Mootien, Yoganaden, Mourvillier, Bruno, Navellou, Jean Christoph, Noret, M, Peiffer- Smadja, Nathan, Peytavin, Gilles, Pialoux, Gilles, Pilmis, Benoît, Piroth, Lionel, Poindron, Vincent, Poissy, Julien, Pourcher, Valerie, Quenot, Jean Pierre, Raffi, Francois, Reignier, Jean, Richard, Jean Christoph, Robert, Céline, Saillard, Juliette, Sayre, Naomi, Senneville, Eric, Stefan, Francois, Tellier, Marie Capucine, Terzi, Nicolas, Textoris, Julien, Thiery, Guillame, Timsit, Jean Francois, Tolsma, Violaine, Tubiana, Sarah, Wallet, Florent, Yazdanpanah, Yazdan, Zerbib, Yoann, Aguilar, Carlos, Erazo, Laura, Fiallos, Angel, Figueroa, Rosbinda, Flores, Juan Jose, Melendez, Lesddyy, Moncada, Wendy, Abraham, Ooriapadickal Cherian, Acharya, Chetankumar, Aedula, Vinaya Sekhar, Aggarwal, Richa, Agrawal, Nishant, Agrawal, Umang, Agrawal, Abhishekh, Ahmad, Mohammad, Atal, Shubham, Babu, Avinash, Baidya, Dalim Kumar, Balachandran, Amith, Bangar, Rakhee, Bhadade, Rakesh, Bhandari, Sudhir, Bhapal, Meghavi, Bhardwaj, Pankaj, Bhati, Gaurav, Bhatia, Pradeep, Bhatt, Krishnakant, Bingi, Thrilok Chander, Borse, Rohidas, Buch, Vyom, Chand, Dipti, Chandwani, Ashish, Charan, Jaykaran, Chaudhari, Mayur, Chaudhari, Kirti, Chaudhary, Vipul, Chauhan, Nishant, Chikara, Gaurav, Daswani, Bharti, de Souza, Rosemarie, Desai, Chetna, Divakar, Balusamy, Divhare, Sujeet, Dorairajan, Suresh Kumar, Dutt, Naveen, Ethirajan, Therani Rajan, Gamit, Amit, Gamit, Sweta, Garg, Mahendra, Goenka, Ajay, Goenka, Aniket, Guleria, Randeep, Gupta, Paras, Gupta, Nivedita, Gupta, Madhur, Harde, Minal, Ingle, Vaibhav, Iyer, Shivkumar, Jamalapuram, Vaishnavi, Jayanthi, Rangarajan, Joshi, Rajnish, Kadam, Abhijeet, Kalakuntla, Hemanth, Kalikar, Mrunalini, Kalme, Sayali, Kamble, Suchit, Kant, Ravi, Kantharia, Bansari, Kashikar, Arundhati, Kavishvar, Abhay, Kayina, Choro Athipro, Kerkar, Pranali, Khadanga, Sagar, Khandare, Sagar, Kokate, Pranjali, Komathi, Jayavelu, Krishnan, Vijay, Krishnan, Jayasree, Krishnan, Sumitra, Kulur Mukhyaprana, Sudha, Kumarasamy, N, Mahavar, Sunil, Maitra, Souvik, Majumdar, Falguni, Malhotra, Supriya, Mamulwar, Megha, Malini, Padma, Marwah, Vikas, Maurya, Akhilesh, Mehta, Kedar, Mesipogu, Rajarao, Misra, Shobha, Mitra, Sajal, Mittal, Ankit, Mohan, Bharathi, Momin, Mohmmedirfan, Nag, Vijaya, Nagarajan, Ramakrishnan, Nagmani, Kammili, Narlawar, Uday, Natarajan, Gopalakrishnan, Nischal, Neeraj, Ogale, Dhananjay, Palat, Paltial, Panda, Prasan, Panda, Samiran, Pandya, Amee, Parate, Rohit, Paritekar, Arunita, Patel, Parvati, Patel, Chetna, Patel, Sunaina, Patel, Vitan, Patel, Deep, Patel, Harshad, Patil, Girish, Peter, Deepu, Prasad, Durga, Purohit, Vimlesh, Rabindrarajan, Ebenezer, Ranganathan, Lakshmiarasimhan, Rao, Tushara, Rao, Chakradhara, Rathod, Chirag, Raval, Devang, Ray, Avik, Reddy, Kamini, Rege, Sujata, Revathi, Ayyasamy, Roy, Dhara, Saigal, Saurabh, Sane, Suvarna, Sangale, Shashi, Seetharaman, Krishnamoorthy, Selvamuthu, Poongulali, Seshaiah, Kurada Venkata, Shadrach, Benhur, Shah, Jignesh, Shah, Sonal, Sharma, Swati, Sharma, Raman, Sharma, Shrikant, Singh, Krishna, Singh, Anil, Singh, Arjeet, Singhai, Abhishek, Soneja, Manish, Soni, Kapil Dev, Subhan, Thasneem banu, Subramaniam, Sudharshini, Sudarsanam, Thambu David, Sudarsi, Ravindra Kumar, Suleman, Dawood, Suthar, Nilay, Talati, Shriraj, Tambe, Murlidhar, Tejomurtula, Tilak, Tirupakuzhi Vijayaraghavan, Bharatkumar, Trikha, Anjan, Trivedi, Aarti, Udwadia, Zarir, Upadhyay, Kamlesh, Vasava, Ashwin, Vasudevan, Damodaran, Velayudham, Rajendran, Venkatasubramanian, Ramasubramanian, Verma, Mamta, Waghmare, Rakesh, Waikar, Anushka, Wig, Naveet, Afrilia, Annisa Rizky, Amin, Muhammad, Arlinda, Dona, Avrina, Rossa, Bang, Lois, Djaharuddin, Irawaty, Djojo, Aryan, Driyah, Sri Laning, Erastuti, Mila, Fajarwati, Tetra, Harsini, Harsini, Hartantri, Yovita, Herman, Deddy, Isbaniah, Fathiyah, Karyana, Muhammad, Kusuma, Indra, Mahmudji, Harli Amir, Medison, Irvan, Nugroho, Agung, Nurhayati, Nurhayati, Opitasari, Cicih, Pitoyo, Ceva Wicaksono, Pradana, Antonius Arditya, Raharjo, Sofyan Budi, Rahmaini, Ade, Risniati, Yenni, Riyanto, Bambang Sigit, Sajinadiyasa, I Gede Ketut, Sari, Flora Eka, Sitompul, Pompini Agustina, Soedarsono, Soedarsono, Somia, I Ketut Agus, Sugiri, Yani Jane, Sugiyono, Retna Indah, Susanto, Nugroho Harry, Syarif, Armaji Kamaludi, Yulianto, Aris, Afsharian, Mandana, Akhavi Mirab, Atefehsadat, Amini, Fatemeh, Amini, Mahnaz, Ansarin, Khalil, Baba Mahmoodi, Farhang, Baghaei, Parvaneh, Barazandeh, Fateme, Bayani, Masomeh, Dastan, Farzaneh, Ebrahimpour, Soheil, Eghtesad, Sareh, Fallahi, Mohammad Javad, Fallahpoor Golmaee, Fatemeh, Foroghi Ghomi, Seyed Yaser, Ghadir, Mohammad Reza, Gheitani, Mina, Ghiasvand, Fereshteh, Hafizi Lotfabadi, Saied, Hakamifard, Atousa, Hashemi Madani, Shima Sadat, Hormati, Ahmad, Hosseini, Hamed, Janbakhsh, Alireza, Javanian, Mostafa, Joukar, Farahnaz, Kamali, Alireza, Karampour, Amin, Khajavirad, Nasim, Khodabakhshi, Behnaz, Khodadadi, Javad, Khodashahi, Rozita, Kiani Majd, Somaieh, Mahfoozi, Lida, Mahmoodiyeh, Behnam, Mansour-Ghanaei, Fariborz, Mansouri, Feizollah, Mesgarpour, Bita, Mesri, Mehdi, Mikaeili, Haleh, Miladi, Ronak, Moghadami, Mohsen, Mohamadi, Payam, Mohraz, Minoo, Mohseni Afshar, Zeinab, Moogahi, Sasan, Mousavi Anari, Seyed Alireza, Mozaffar, Seyyed Hassan, Mozdourian, Mahnaz, Najafipour, Reza, Najari, Hamidreza, Nazemiyeh, Masoud, Norouzi, Alireza, Pourkazemi, Aydin, Poustchi, Hossein, Saberhosseini, Seyedeh Naeimeh, Saberi, Marzieh, Saber-Moghaddam, Niloufar, Sadeghi, Anahita, Sadeghi Haddad Zavareh, Mahmoud, Sahraian, Mohammad Ali, Salahi, Mehrdad, Salehi, Mohammad Reza, Sarmadian, Hossein, Sayad, Babak, Shirani, Kiana, Shirvani, Maria, Shojaei, Daryanaz, Shokri, Mehran, Siami, Zeinab, Sima, Ali Reza, Soleimani, Alireza, Soltanmohammad, Saedeh, Tabarsi, Payam, Taghizadieh, Ali, Tavassoli, Samaneh, Varnasseri, Mehran, Vaziri, Siavash, Yadyad, Mohammad Jaafar, Yaghoubi, Shoeleh, Yazdanpanah, Yalda, Yousefi, Farid, Zamanian, Mohammad Hossein, Zand, Farid, Zare Hoseinzade, Elham, Bergin, Colm, Cotter, Aoife, de Barra, Eoghan, Jackson, Arthur, Laffey, John, McCarthy, Cormac, Muldoon, Eavan, Sadlier, Corinna, Maguire, Teresa, Angheben, Andrea, Bai, Francesca, Bandera, Alessandra, Barchiesi, Francesco, Bassetti, Matteo, Bisi, Luca, Bonfanti, Paolo, Calò, Federica, Campoli, Caterina, Canovari, Benedetta, Capetti, Amedeo, Castelli, Francesco, Cauda, Roberto, Cingolani, Antonella, Cocco, Nicolò, Coppola, Nicola, Corcione, Silvia, Cremonini, Eleonora, d'Arminio Monforte, Antonella, de Gaetano Donati, Katleen, De Nardo, Pasquale, De Rosa, Francesco Giuseppe, Degioanni, Maria, Della Siega, Paola, Di Bella, Stefano, Drera, Bruno, Focà, Emanuele, Fornabaio, Chiara, Galli, Massimo, Giacomazzi, Donatella, Gori, Andrea, Gustinetti, Giulia, Iannuzzi, Francesca, Kertusha, Blerta, Lamonica, Silvia, Lichtner, Miriam, Lupia, Tommaso, Luzzati, Roberto, Macera, Margherita, Menatti, Elisabetta, Merelli, Maria, Merlini, Esther, Monari, Caterina, Pan, Angelo, Pecori, Davide, Pezzani, Diletta, Riccardi, Niccolò, Rodari, Paola, Roldan, Eugenia, Rovere, Pierangelo, Rusconi, Stefano, Scabini, Silvia, Tascini, Carlo, Viale, Pierluigi, Vincenzi, Marcello, Zuccalà, Paola, Zucchi, Patrizia, Al-Roomi, Moudhi, Al-Sabah, Salman, Schrapp, Kelly, Hassoun, Mahmoud, Matar, Madonna, Dbouni, Oussaima, Yared, Nadine, Saliba, Michele, Farra, Anna, Riachi, Moussa, Zablockiene, Birute, Reuter, Jean, Staub, Therese, Ab Wahab, Suhaila, Chew, Chun Keat, Chua, Hock Hin, Goh, Pik Pin, Lee, Heng Gee, Leong, Chee Loon, Low, Lee Lee, Mak, Wen Yao, Mohamed Gani, Yasmin, Muhamad, Dzawani, Zaidan, Nor Zaila, Ducker, Camilla, Demiri, Ilir, Aballi, Saad, Berg, Åse, Blomberg, Bjørn, Dalgard, Olav, Dyrhol-Riise, Anne Ma, Eiken, Ragnhild, Ernst, Gernot, Hannula, Ranula, Haugli, Metter, Heggelund, Lars, Hoel, Hedda, Hoff, Dag Arne Lihaug, Holten, Aleksander Rygh, Johannessen, Asgeir, Kåsine, Trine, Kildal, Anders Benjamin, Kittang, Bård Reikvam, Nezvalova-Henriksen, Katerina, Olsen, Inge Christoffer, Olsen, Roy Bjørkolt, Skei, Nina Vibeche, Skudal, Hilde, Tholin, Birgitte, Thoresen, Lars, Trøseid, Marius, Tveita, Anders, Vinge, Leif, Ystrøm, Carl Magnus, Al Jahdhami, Issa, AlNaamani, Khalid, Al Balushi, Zakariya, Pandak, Nenad, Abbas, Salma, Akhtar, Nasim, Azam, Sumeyya, Begum, Dilshad, Hassan, Sadia, Herekar, Fivzia, Khan, Shahzaib, Khan, Ejaz Ahmed, Mahmood, Syed Faisal, Nasir, Nosheen, Rahim, Anum, Sarfaraz, Samreen, Shaikh, Qurat-ul-Ain, Sultan, Faisal, Walayat, Usman, Agurto-Lescano, Erika Cecilia, Alcantara-Díaz, Andrés Martín, Alva-Correa, Ana María, Alvarado-Moreno, José Gustavo, Ángeles-Padilla, Bethsabé, Arbañil-Huamàn, Hugo César, Ávila-Reyes, Pool Christopher, Azañero-Haro, Johan Alexander, Barreto-Rocchetti, Luis Guillermo, Benitez-Peche, Jorge Marko A., Bernal-Màlaga, Karla Hortencia, Cabrera-Portillo, Liliana Norma, Carazas-Chavarry, Reynaldo Javier, Càrcamo, Paloma Mariana, Casimiro-Porras, Indira Catalina, Castillo-Espinoza, Jhuliana, Chacaltana-Huarcaya, Jesús Norberto, Cornejo-Valdivia, Carla Raquel, Cruz-Chereque, Augusto, Del-Aguila-Torres, Keith Cayetano Marcelino, Díaz-Chipana, Erika, Flores-Valdez, Neil, Franco-Vàsquez, Rosanna Andrea, Gallegos-López, Roxana Consuelo, Gastiaburú-Rodriguez, Dauma Yesenia, Gianella-Malca, Gonzalo Ernesto, Gomero-Lopez, Andrés Alonso, Hercilla-Vàsquez, Luis Enrique, Hueda-Zavaleta, Miguel Ángel, Ibarcena-Llerena, Claudia Vanessa, Iberico-Barrera, Carlos Alberto, Inquilla-Castillo, Miguel Angel, Juàrez-Eyzaguirre, Jesus Alberto, Laca-Barrera, Manuel, León-Jiménez, Franco, Luna-Wilson, Carla Vanessa, Màlaga, German, Marin, Ricardo, Mejía-Cordero, Fernando, Mendoza-Laredo, Juan Arturo, Meregildo-Rodríguez, Edinson Dante, Miranda-Manrique, Gonzalo Francisco, Olivera-Chaupis, Marco, Ortega-Monasterios, Fatima Josefina, Otazú-Ybàñez, Jimmy Pedro, Paredes-Moreno, María Angélica, Peña-Mayorga, Claudia Ximena, Peña-Vàsquez, Olivia del Carmen, Peña-Villalobos, Alejandro, Ponce, Oscar J, Ponte-Fernandez, Katherin Estefania, Pro, Jose, Quispe-Nolazco, César Miguel, Ramos-Samanez, Manuel Efrain, Rojas-Murrugarra, Kory Mirtha, Samanez-Pérez, Jorge Mauro, Sànchez-Carrillo, Halbert Chrostian, Sànchez-Garavito, Epifanio, Sànchez-Sevillano, Ricardo Manuel, Sandoval-Manrique, Hernan, Santos-Revilla, Gabriela, Silva-Ramos, Julio Antonio, Solano-Ico, Manuel Alberto, Soto, Alonso, Sotomayor-Woolcott, Giannilu Michelle, Tapia-Orihuela, Ruben Kevin Arnold, Terrazas-Obregón, Carmen Sara, Terrones-Levano, Victor Francisco, Ticona-Huaroto, Cesar Eduardo, Torres-Ninapayta, Walter, Torres-Ruiz, Oscar Martin, Ugarte-Mercado, Dario, Vargas-Anahua, Orlando José, Vàsquez-Becerra, Ruben Dario, Vàsquez-Cerro, José Gabriel, Villegas-Chiroque, Miguel, Williams, Anna Larson, Yauri-Lazo, Randi Mauricio, Abad, Cybele Lara, Andales-Bacolcol, Silverose Ann, Arcegono, Marlon, Arches, Jamie, Astudillo, Mary Grace, Aventura, Emily, Awing, Arlyn, Bala, Mishelle Vonnabie, Bello, Jia An, Blanco, Peter, Benedicto, Jubert, Buno, Susana, Cabrera, Justine, Cajulao, Thea Pamela, Caoili, Janice, Casiple-Amsua, Lina, Catambing, Victor, Chin, Inofel, Chua, Ma. Bernadette, Chua, Mitzi Marie, Climacosa, Fresthel Monica, David-Wang, Aileen, De los Reyes, Virginia, Europa, Gilly May, Fernandez, Lenora, Francisco, Jorge, Garcia, Gerard, Garcia, Jemelyn, Gler, Maria Tarcela, Isidro, Marie Grace Dawn, Javier, Rozelle Jade, Kwek, Marion, Lansang, Mary Ann, Lee, Aileen, Li, Kingbherly, Llanes, Mark Ramon Victor, Llorin, Ryan, Macadato, Omar Khayyam, Malundo, Anna Flor, Mercado, Maria Elizabeth, Mujeres, Mercedes, Nepomuceno, Marisse, Ngo-Sanchez, Katha, Orden, Mary Claire, Pablo-Villamor, Maria Philina, Paez, Ruel Dionisio, Palmes, Patricio, Panaligan, Marion, Quinivista-Yoon, Jenny Mae, Ramos, Mary Shiela Ariola, Ramos -Penalosa, Christine, Reyes, Sheila Marie, Roa, Kathryn, Roman, Arthur Dessi, Rosario, Minette Claire, Roxas, Evalyn, Santos, Lourdes Ella Gonzales, Soldevilla, Helmar, Solante, Rontgene, Suaco, Jane, Tagarda, Daisy, Tang, Issa Rufina, Te, Bob, Teo, Dennis, Tibayan, Christopher John, Villalobos, Ralph Elvi, Ymbong, Duane Richard, Zabat, Gelza Mae, Batkova, Stepanka, Cardoso, Orlando, Garrote, Ana-Raquel, Lino, Sara, Manata, Maria-José, Pinheiro, Helder, Póvoas, Diana, Ramirez, Freddy, Seixas, Diana, Naji, Assem, Al Gethamy, M Al, AL-Mulaify, Mohammed Sami, Al Maghraby, Reem, Alrajhi, A, Al Sharidi, Aynaa, Alotaibi, Naif, AlShaharani, F, Barry, Mazin, Ghonem, Leen, Khalel, Anas, Kharaba, Ayman Mohammed, Alabdan, Lulwah, AlAbdullah, Mohammed Sharaf, Al Shabib, Abdullah, Bengu, Simangele, Bennet, Jacklyn, Dubula, Thozama, Howell, Pauline, Janse van Vuuren, Cloete, Kalla, Ismail, Lifson, Aimee, Maasdorp, Shaun, Magua, Nombulelo, Maluleke, Vongani, Mbhele, Nokuphiwa, Mdladla, Nathi, Mendelson, Mark, Menezes, Colin, Mwelase, Thando, Nchabeleng, Maphoshane, Palanee-Phillips, Thesla, Parker, Victoria, Rassool, Mohammed, Reeder, Paul, Sossen, Bianca, Steyn, Dewald, Tsitsi, Merika, van Blydenstein, Sarah Alex, Venter, Michelle, Van Vuuren, Janse, Venturas, Jacquie, Abad Pérez, Daniel, Abenza, Maria José, Alarcón-Payer, Carolina, Armero Garrigos, Eva, Arribas, Jose Ramon, Ascaso, Ana, Berenguer, Juan, Cabello-Clotet, Noemí, Chamorro Tojeiro, Sandra, Cuenca-Acevedo, Rafael, de la Calle, Fernando, Del Toro, Maria Dolores, Díaz Pollàn, Beatriz, Diez, Cristina, Esquillor-Rodrigo, María José, Estrada, Vicente, Fanciulli, Chiara, Fanjul, Francisco, Fernàndez de Orueta, Lucía, Ferre, Adrian, Ferreira Pasos, Eva Maria, Gainzarain-Arana, Juan-Carlos, Garcia, Felipe, García Deltoro, Miguel, Goikoetxea Agirre, Ane Josune, Gómez Barquero, Julia, Gomez-Huelgas, Ricardo, Gonzàlez Moraleja, Julio, Guijarro, Carlos, Gutierrez, Felix, Guzmàn, Jesús, Ibarguren, Maialen, Iribarren, Jose Antonio, Jerusalem, Koen, Juan Arribas, Arturo, Lalueza, A, Leone, Antonio, Lopez Azkarreta, Iñigo, Lozano-Martin, Daniel, Lucendo, Alfredo J, Luengo López, Mariella, Martín Oterino, JA, Masa, JF, Merino, Esperanza, Monge-Maillo, Begoña, Moran-Rodríguez, Miguel-Angel, Muñez Rubio, Elena, Muñoz Sanchez, Josefa, Nuñez Orantos, Maria Jose, Nuño, Enrique, Ortiz-De-Zarate-Ibarra, Zuriñe, Pagàn-Muñoz, Bàrbara, Paño-Pardo, José Ramón, Peñaranda, Maria, Pérez Chica, Gerardo, Pérez Fernàndez, AM, Pérez-López, Carmen, Polo San Ricardo, Victor, Portu-Zapirain, Joseba, Puchades, Francesco, Rivas Paterna, Ana Belen, Rodríguez Vidigal, Francisco F, Rodríguez-Baño, Jesus, Ruiz-Seco, Pilar, Ryan, Pablo, Saez-De-Adana, Ester, Salas, Rosario, Salavert Lletí, Miguel, Sandoval, Raquel, Toyas-Miazza, Carla, Valencia, Jorge, Vargas, Emilio, Velasco, Maria, Von Wichmann, Miguel Angel, Bosshard, Andreas, Calmy, Alexandra, Castro, Tiago, Cavassini, Matthias, Clerc, Olivier, Conen, Anna, Desbaillets, Nicolas, Desgranges, Florian, Duss, Francois, Emonet, Stephane, Erard, Veronique, Eyer, Myriam, Fayet-Mello, Aurélie, Flammer, Yvonne, Friedl, Andrée, Fulchini, Rosamaria, Furrer, Hansjakob, Garin, Nicolas, Gastberger, Salome, Greiner, Michael, Haefliger, David, Haubitz, Sebastian, Hoffmann, Matthias, Isenring, Egon, Jakopp, Barbara, Lampert, Markus, Marinosci, Annalisa, Martin, Yvonne, Petignat, Pierre-Auguste, Piso, Rein Jan, Prendki, Virginie, Rutishauser, Jonas, Schaefer, Elisabeth, Schmiedel, Yvonne, Schwery, Stefan, Stavropoulou, Elisavet, Stoeckle, Marcel, Suttels, Veronique, Thurnher, Maria Christine, van den Bogaart, Lorena, West, Emily, Wiegand, Jan, and Wiggli, Benedikt

Published
2022
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4. Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms

Author

Deforth, Manja, Gebhard, Caroline E., Bengs, Susan, Buehler, Philipp K., Schuepbach, Reto A., Zinkernagel, Annelies S., Brugger, Silvio D., Acevedo, Claudio T., Patriki, Dimitri, Wiggli, Benedikt, Twerenbold, Raphael, Kuster, Gabriela M., Pargger, Hans, Schefold, Joerg C., Spinetti, Thibaud, Wendel-Garcia, Pedro D., Hofmaenner, Daniel A., Gysi, Bianca, Siegemund, Martin, Heinze, Georg, Regitz-Zagrosek, Vera, Gebhard, Catherine, and Held, Ulrike

Published
2022
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5. Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort

Author

Haller, Sabine, Güsewell, Sabine, Egger, Thomas, Scanferla, Giulia, Thoma, Reto, Leal-Neto, Onicio B., Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, Möller, J. Carsten, Rieder, Philip, Rütti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andrée, Vernazza, Pietro, Kahlert, Christian R., and Kohler, Philipp

Published
2022
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6. Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

Author

Weiner, January, 3rd, Suwalski, Phillip, Holtgrewe, Manuel, Rakitko, Alexander, Thibeault, Charlotte, Müller, Melina, Patriki, Dimitri, Quedenau, Claudia, Krüger, Ulrike, Ilinsky, Valery, Popov, Iaroslav, Balnis, Joseph, Jaitovich, Ariel, Helbig, Elisa T, Lippert, Lena J, Stubbemann, Paula, Real, Luis M, Macías, Juan, Pineda, Juan A, Fernandez-Fuertes, Marta, Wang, Xiaomin, Karadeniz, Zehra, Saccomanno, Jacopo, Doehn, Jan-Moritz, Hübner, Ralf-Harto, Hinzmann, Bernd, Salvo, Mauricio, Blueher, Anja, Siemann, Sandra, Jurisic, Stjepan, Beer, Juerg H., Rutishauser, Jonas, Wiggli, Benedikt, Schmid, Hansruedi, Danninger, Kathrin, Binder, Ronald, Corman, Victor M, Mühlemann, Barbara, Arjun Arkal, Rao, Fragiadakis, Gabriela K., Mick, Eran, COMET, Consortium, Calfee, Carolyn S., Erle, David J., Hendrickson, Carolyn M., Kangelaris, Kirsten N., Krummel, Matthew F., Woodruff, Prescott G., Langelier, Charles R., Venkataramani, Urmila, García, Federico, Zyla, Joanna, Drosten, Christian, Alice, Braun, Jones, Terry C, Suttorp, Norbert, Witzenrath, Martin, Hippenstiel, Stefan, Zemojtel, Tomasz, Skurk, Carsten, Poller, Wolfgang, Borodina, Tatiana, Pa-COVID, Study Group, Ripke, Stephan, Sander, Leif E, Beule, Dieter, Landmesser, Ulf, Guettouche, Toumy, Kurth, Florian, and Heidecker, Bettina

Published
2021
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7. Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among hospital workers – A multicentre cross-sectional study

Author

Kahlert, Christian R., Persi, Raphael, Güsewell, Sabine, Egger, Thomas, Leal-Neto, Onicio B., Sumer, Johannes, Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, Möller, J. Carsten, Rieder, Philip, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Albrich, Werner C., Babouee Flury, Baharak, Besold, Ulrike, Fehr, Jan, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andrée, Vernazza, Pietro, and Kohler, Philipp

Published
2021
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8. Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020

Author

Gebhard, Caroline E, Sütsch, Claudia, Gebert, Pimrapat, Gysi, Bianca, Bengs, Susan, Todorov, Atanas, Deforth, Manja, Buehler, Philipp K, Meisel, Alexander, Schuepbach, Reto A, Zinkernagel, Annelies S, Brugger, Silvio D, Acevedo, Claudio, Patriki, Dimitri, Wiggli, Benedikt, Beer, Jürg H, Friedl, Andrée, Twerenbold, Raphael, Kuster, Gabriela M, Pargger, Hans, Tschudin-Sutter, Sarah, Schefold, Joerg C, Spinetti, Thibaud, Henze, Chiara, Pasqualini, Mina, Sager, Dominik F, Mayrhofer, Lilian, Grieder, Mirjam, Tontsch, Janna, Franzeck, Fabian C, et al, Gebhard, Caroline E, Sütsch, Claudia, Gebert, Pimrapat, Gysi, Bianca, Bengs, Susan, Todorov, Atanas, Deforth, Manja, Buehler, Philipp K, Meisel, Alexander, Schuepbach, Reto A, Zinkernagel, Annelies S, Brugger, Silvio D, Acevedo, Claudio, Patriki, Dimitri, Wiggli, Benedikt, Beer, Jürg H, Friedl, Andrée, Twerenbold, Raphael, Kuster, Gabriela M, Pargger, Hans, Tschudin-Sutter, Sarah, Schefold, Joerg C, Spinetti, Thibaud, Henze, Chiara, Pasqualini, Mina, Sager, Dominik F, Mayrhofer, Lilian, Grieder, Mirjam, Tontsch, Janna, Franzeck, Fabian C, and et al

Abstract

Background: Women are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well as sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown. Aim: We assessed the impact of sex and gender on PASC in a Swiss population. Method: Our multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients and hospitalised patients with PCR-confirmed SARS-CoV-2 infection.ResultsAmong those who remained outpatients during their first infection, women reported persisting symptoms more often than men (40.5% vs 25.5% of men; p < 0.001). This sex difference was absent in hospitalised patients. In a crude analysis, both female biological sex (RR = 1.59; 95% CI: 1.41-1.79; p < 0.001) and a score summarising gendered sociocultural variables (RR = 1.05; 95% CI: 1.03-1.07; p < 0.001) were significantly associated with PASC. Following multivariable adjustment, biological female sex (RR = 0.96; 95% CI: 0.74-1.25; p = 0.763) was outperformed by feminine gender-related factors such as a higher stress level (RR = 1.04; 95% CI: 1.01-1.06; p = 0.003), lower education (RR = 1.16; 95% CI: 1.03-1.30; p = 0.011), being female and living alone (RR = 1.91; 95% CI: 1.29-2.83; p = 0.001) or being male and earning the highest income in the household (RR = 0.76; 95% CI: 0.60-0.97; p = 0.030). Conclusion: Specific sociocultural parameters that differ in prevalence between women and men, or imply a unique risk for women, are predictors of PASC and may explain, at least in part, the higher incidence of PASC in women. Once patients are hospitalised during acute infection, sex differences in PASC are no longer evident.

Published
2024

9. Effectiveness of a Chlorhexidine Dressing on Silver-coated External Ventricular Drain–associated Colonization and Infection : A Prospective Single-blinded Randomized Controlled Clinical Trial

Author

Roethlisberger, Michel, Moffa, Giusi, Fisch, Urs, Wiggli, Benedikt, Schoen, Stephan, Kelly, Christopher, Leu, Severina, Croci, Davide, Zumofen, Daniel W., Cueni, Nadine, Nogarth, Danica, Schulz, Marianne, Bucher, Heiner C., Weisser-Rohacek, Maja, Wasner, Morten-Goetz, Widmer, Andreas F., and Mariani, Luigi

Published
2018

10. Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study

Author

Kohler, Philipp, Güsewell, Sabine, Seneghini, Marco, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Möller, J. Carsten, Rieder, Philip, Ruetti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, and Kahlert, Christian R.

Published
2021
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14. Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020.

Author

Gebhard, Caroline E., Sütsch, Claudia, Gebert, Pimrapat, Gysi, Bianca, Bengs, Susan, Todorov, Atanas, Deforth, Manja, Buehler, Philipp K., Meisel, Alexander, Schuepbach, Reto A., Zinkernagel, Annelies S., Brugger, Silvio D., Acevedo, Claudio, Patriki, Dimitri, Wiggli, Benedikt, Beer, Jürg H., Friedl, Andrée, Twerenbold, Raphael, Kuster, Gabriela M., and Pargger, Hans

Published
2024
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15. Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study)

Author

Kohler, Philipp, Babouee Flury, Baharak, Güsewell, Sabine, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Meier Kleeb, Dorette, Möller, J Carsten, Ortner, Manuela, Rieder, Philip, Ruetti, Markus, Schmid, Hans-Ruedi, Stocker, Reto, Vuichard-Gysin, Danielle, Speer, Oliver, Wiggli, Benedikt, Besold, Ulrike, McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, Kahlert, Christian R, and Kuster, Stefan P

Subjects
610 Medicine & health
Abstract

The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction.

Published
2023

16. Long-Term Mortality after New-Onset Atrial Fibrillation in COVID-19

Author

Jurisic, Stjepan, primary, Komminoth, Mathis, additional, Todorov, Atanas, additional, Bertschi, Daniela A., additional, Jurisic, Martin, additional, Vranjic, Ivica, additional, Wiggli, Benedikt, additional, Schmid, Hansruedi, additional, Gebhard, Catherine, additional, Gebhard, Caroline E., additional, Heidecker, Bettina, additional, Beer, Jürg-Hans, additional, and Patriki, Dimitri, additional

Published
2023
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17. Long-Term Mortality after New-Onset Atrial Fibrillation in COVID-19

Author

Jurisic, Stjepan, Komminoth, Mathis; https://orcid.org/0000-0002-0024-6284, Todorov, Atanas, Bertschi, Daniela A; https://orcid.org/0009-0009-5983-1160, Jurisic, Martin, Vranjic, Ivica; https://orcid.org/0000-0002-2442-636X, Wiggli, Benedikt, Schmid, Hansruedi, Gebhard, Catherine; https://orcid.org/0000-0001-7240-5822, Gebhard, Caroline E; https://orcid.org/0000-0003-4975-2679, Heidecker, Bettina; https://orcid.org/0000-0002-3811-7920, Beer, Jürg-Hans; https://orcid.org/0000-0002-7199-0406, Patriki, Dimitri; https://orcid.org/0000-0001-6364-0927, Jurisic, Stjepan, Komminoth, Mathis; https://orcid.org/0000-0002-0024-6284, Todorov, Atanas, Bertschi, Daniela A; https://orcid.org/0009-0009-5983-1160, Jurisic, Martin, Vranjic, Ivica; https://orcid.org/0000-0002-2442-636X, Wiggli, Benedikt, Schmid, Hansruedi, Gebhard, Catherine; https://orcid.org/0000-0001-7240-5822, Gebhard, Caroline E; https://orcid.org/0000-0003-4975-2679, Heidecker, Bettina; https://orcid.org/0000-0002-3811-7920, Beer, Jürg-Hans; https://orcid.org/0000-0002-7199-0406, and Patriki, Dimitri; https://orcid.org/0000-0001-6364-0927

Abstract

Background: Atrial fibrillation (AF) has been described as a common cardiovascular manifestation in patients suffering from coronavirus disease 2019 (COVID-19) and has been suggested to be a potential risk factor for a poor clinical outcome. Methods: In this observational study, all patients hospitalized due to COVID-19 in 2020 in the Cantonal Hospital of Baden were included. We assessed clinical characteristics, in-hospital outcomes as well as long-term outcomes with a mean follow-up time of 278 (±90) days. Results: Amongst 646 patients diagnosed with COVID-19 (59% male, median age: 70 (IQR: 59-80)) in 2020, a total of 177 (27.4%) patients were transferred to the intermediate/intensive care unit (IMC/ICU), and 76 (11.8%) were invasively ventilated during their hospitalization. Ninety patients (13.9%) died. A total of 116 patients (18%) showed AF on admission of which 34 (29%) had new-onset AF. Patients with COVID-19 and newly diagnosed AF were more likely to require invasive ventilation (OR: 3.5; p = 0.01) but did not encounter an increased in-hospital mortality. Moreover, AF neither increased long-term mortality nor the number of rehospitalizations during follow-up after adjusting for confounders. Conclusions: In patients suffering from COVID-19, the new-onset of AF on admission was associated with an increased risk of invasive ventilation and transfer to the IMC/ICU but did not affect in-hospital or long-term mortality.

Published
2023

18. Risk and symptoms of COVID-19 in health professionals according to baseline immune status and booster vaccination during the Delta and Omicron waves in Switzerland-A multicentre cohort study

Author

Babouee Flury, Baharak, Güsewell, Sabine, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Meier Kleeb, Dorette, Möller, J Carsten, Rieder, Philip, Rütti, Markus, Schmid, Hans-Ruedi, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Kuster, Stefan P, Kahlert, Christian R, and Kohler, Philipp

Subjects
SARS-CoV-2, Vaccination, Humans, COVID-19, 610 Medicine & health, Viral Vaccines, Prospective Studies, 610 Medizin und Gesundheit, Switzerland
Abstract

BACKGROUND Knowledge about protection conferred by previous Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and/or vaccination against emerging viral variants allows clinicians, epidemiologists, and health authorities to predict and reduce the future Coronavirus Disease 2019 (COVID-19) burden. We investigated the risk and symptoms of SARS-CoV-2 (re)infection and vaccine breakthrough infection during the Delta and Omicron waves, depending on baseline immune status and subsequent vaccinations. METHODS AND FINDINGS In this prospective, multicentre cohort performed between August 2020 and March 2022, we recruited hospital employees from ten acute/nonacute healthcare networks in Eastern/Northern Switzerland. We determined immune status in September 2021 based on serology and previous SARS-CoV-2 infections/vaccinations: Group N (no immunity); Group V (twice vaccinated, uninfected); Group I (infected, unvaccinated); Group H (hybrid: infected and ≥1 vaccination). Date and symptoms of (re)infections and subsequent (booster) vaccinations were recorded until March 2022. We compared the time to positive SARS-CoV-2 swab and number of symptoms according to immune status, viral variant (i.e., Delta-dominant before December 27, 2021; Omicron-dominant on/after this date), and subsequent vaccinations, adjusting for exposure/behavior variables. Among 2,595 participants (median follow-up 171 days), we observed 764 (29%) (re)infections, thereof 591 during the Omicron period. Compared to group N, the hazard ratio (HR) for (re)infection was 0.33 (95% confidence interval [CI] 0.22 to 0.50, p < 0.001) for V, 0.25 (95% CI 0.11 to 0.57, p = 0.001) for I, and 0.04 (95% CI 0.02 to 0.10, p < 0.001) for H in the Delta period. HRs substantially increased during the Omicron period for all groups; in multivariable analyses, only belonging to group H was associated with protection (adjusted HR [aHR] 0.52, 95% CI 0.35 to 0.77, p = 0.001); booster vaccination was associated with reduction of breakthrough infection risk in groups V (aHR 0.68, 95% CI 0.54 to 0.85, p = 0.001) and H (aHR 0.67, 95% CI 0.45 to 1.00, p = 0.048), largely observed in the early Omicron period. Group H (versus N, risk ratio (RR) 0.80, 95% CI 0.66 to 0.97, p = 0.021) and participants with booster vaccination (versus nonboosted, RR 0.79, 95% CI 0.71 to 0.88, p < 0.001) reported less symptoms during infection. Important limitations are that SARS-CoV-2 swab results were self-reported and that results on viral variants were inferred from the predominating strain circulating in the community at that time, rather than sequencing. CONCLUSIONS Our data suggest that hybrid immunity and booster vaccination are associated with a reduced risk and reduced symptom number of SARS-CoV-2 infection during Delta- and Omicron-dominant periods. For previously noninfected individuals, booster vaccination might reduce the risk of symptomatic Omicron infection, although this benefit seems to wane over time.

Published
2022

19. Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms

Author

Deforth, Manja, primary, Gebhard, Caroline Eva, additional, Bengs, Susan, additional, Buehler, Karl Philipp, additional, Schuepbach, Reto, additional, Zinkernagel, Annelies, additional, Brugger, Silvio Daniel, additional, Acevedo, Claudio, additional, Patriki, Dimitri, additional, Wiggli, Benedikt, additional, Twerenbold, Raphael, additional, Kuster, Gabriela, additional, Pargger, Hans, additional, Schefold, Joerg, additional, Spinetti, Thibaud, additional, Wendel-Garcia, Pedro, additional, Hofmaenner, Daniel, additional, Gysi, Bianca, additional, Siegemund, Martin, additional, Heinze, Georg, additional, Regitz-Zagrosek, Vera, additional, Gebhard, Catherine, additional, and Held, Ulrike, additional

Published
2022
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20. «Fièvre prétibiale»

Author

Ruckert, Donat, primary, Calligaris-Maibach, Romana C., additional, Beer, Jrg, additional, and Wiggli, Benedikt, additional

Published
2022
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21. «Prätibiales Fieber»

Author

Ruckert, Donat, primary, Calligaris-Maibach, Romana C., additional, Beer, Jrg, additional, and Wiggli, Benedikt, additional

Published
2022
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22. Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms

Author

Deforth, Manja; https://orcid.org/0000-0002-1111-1799, Gebhard, Caroline E; https://orcid.org/0000-0003-4975-2679, Bengs, Susan; https://orcid.org/0000-0003-2424-3894, Buehler, Philipp K; https://orcid.org/0000-0003-4690-9896, Schuepbach, Reto A; https://orcid.org/0000-0002-7058-4377, Zinkernagel, Annelies S; https://orcid.org/0000-0003-4700-1118, Brugger, Silvio D; https://orcid.org/0000-0001-9492-9088, Acevedo, Claudio T; https://orcid.org/0000-0002-3624-9401, Patriki, Dimitri; https://orcid.org/0000-0001-6364-0927, Wiggli, Benedikt, Twerenbold, Raphael; https://orcid.org/0000-0003-3814-6542, Kuster, Gabriela M, Pargger, Hans, Schefold, Joerg C, Spinetti, Thibaud, Wendel-Garcia, Pedro D; https://orcid.org/0000-0001-7775-3279, Hofmaenner, Daniel A; https://orcid.org/0000-0002-9334-7753, Gysi, Bianca, Siegemund, Martin, Heinze, Georg, Regitz-Zagrosek, Vera; https://orcid.org/0000-0002-3566-3467, Gebhard, Catherine; https://orcid.org/0000-0001-7240-5822, Held, Ulrike; https://orcid.org/0000-0003-3105-5840, Deforth, Manja; https://orcid.org/0000-0002-1111-1799, Gebhard, Caroline E; https://orcid.org/0000-0003-4975-2679, Bengs, Susan; https://orcid.org/0000-0003-2424-3894, Buehler, Philipp K; https://orcid.org/0000-0003-4690-9896, Schuepbach, Reto A; https://orcid.org/0000-0002-7058-4377, Zinkernagel, Annelies S; https://orcid.org/0000-0003-4700-1118, Brugger, Silvio D; https://orcid.org/0000-0001-9492-9088, Acevedo, Claudio T; https://orcid.org/0000-0002-3624-9401, Patriki, Dimitri; https://orcid.org/0000-0001-6364-0927, Wiggli, Benedikt, Twerenbold, Raphael; https://orcid.org/0000-0003-3814-6542, Kuster, Gabriela M, Pargger, Hans, Schefold, Joerg C, Spinetti, Thibaud, Wendel-Garcia, Pedro D; https://orcid.org/0000-0001-7775-3279, Hofmaenner, Daniel A; https://orcid.org/0000-0002-9334-7753, Gysi, Bianca, Siegemund, Martin, Heinze, Georg, Regitz-Zagrosek, Vera; https://orcid.org/0000-0002-3566-3467, Gebhard, Catherine; https://orcid.org/0000-0001-7240-5822, and Held, Ulrike; https://orcid.org/0000-0003-3105-5840

Abstract

Background: The coronavirus disease 2019 (COVID-19) pandemic demands reliable prognostic models for estimating the risk of long COVID. We developed and validated a prediction model to estimate the probability of known common long COVID symptoms at least 60 days after acute COVID-19. Methods: The prognostic model was built based on data from a multicentre prospective Swiss cohort study. Included were adult patients diagnosed with COVID-19 between February and December 2020 and treated as outpatients, at ward or intensive/intermediate care unit. Perceived long-term health impairments, including reduced exercise tolerance/reduced resilience, shortness of breath and/or tiredness (REST), were assessed after a follow-up time between 60 and 425 days. The data set was split into a derivation and a geographical validation cohort. Predictors were selected out of twelve candidate predictors based on three methods, namely the augmented backward elimination (ABE) method, the adaptive best-subset selection (ABESS) method and model-based recursive partitioning (MBRP) approach. Model performance was assessed with the scaled Brier score, concordance c statistic and calibration plot. The final prognostic model was determined based on best model performance. Results: In total, 2799 patients were included in the analysis, of which 1588 patients were in the derivation cohort and 1211 patients in the validation cohort. The REST prevalence was similar between the cohorts with 21.6% (n = 343) in the derivation cohort and 22.1% (n = 268) in the validation cohort. The same predictors were selected with the ABE and ABESS approach. The final prognostic model was based on the ABE and ABESS selected predictors. The corresponding scaled Brier score in the validation cohort was 18.74%, model discrimination was 0.78 (95% CI: 0.75 to 0.81), calibration slope was 0.92 (95% CI: 0.78 to 1.06) and calibration intercept was -0.06 (95% CI: -0.22 to 0.09). Conclusion: The proposed model was validated to id

Published
2022

23. MALE SEX, HLA-C*04:01 AND COVID-19: A RISKY CONSTELLATION

Author

Suwalski, Phillip, primary, Patriki, Dimitri, additional, Quedenau, Claudia, additional, Borodina, Tatiana, additional, Beer, Juerg H., additional, Wiggli, Benedikt, additional, Guettouche, Toumy, additional, Landmesser, Ulf, additional, and Heidecker, Bettina, additional

Published
2022
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24. Additional file 1 of Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort

Author

Haller, Sabine, G��sewell, Sabine, Egger, Thomas, Scanferla, Giulia, Thoma, Reto, Leal-Neto, Onicio B., Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, M��ller, J. Carsten, Rieder, Philip, R��tti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andr��e, Vernazza, Pietro, Kahlert, Christian R., and Kohler, Philipp

Subjects
body regions, fungi, skin and connective tissue diseases
Abstract

Additional file 1. Table S1. List of participating health care institutions with local mask policies (FFP2 or surgical masks), self-reported global adherence, number of healthcare workers (HCW) participating in the study, self-reported FFP2 use in contact with COVID-19 patients, and SARS-CoV-2 seroprevalence among healthcare workers. Table S2. Description and categorization of variables used in analyses. Table S3. Multivariable Cox regression analysis (full model and sensitivity analyses) with outcome ���Time to first SARS-CoV-2- positive nasopharyngeal PCR/rapid antigen test���. Table S4. Complete case analysis excluding observations with missing values: A) Cox regression (outcome time to first SARS-CoV-2 positive swab); B) multivariable logistic regression (outcome SARS-CoV-2 seroconversion). Table S5. Results of multivariable logistic regression analysis (full model and sensitivity analyses) regarding outcome ���SARS-CoV-2 seroconversion���. Table S6. Subgroup analysis of HCW with frequent COVID-19 exposure vs. HCW with less frequent COVID-19 exposure; A) Cox regression (outcome SARS-CoV-2 positive swab); B) multivariable logistic regression (outcome SARS-CoV-2 seroconversion). Table S7. Subgroup analysis of HCW performing AGP: A) Cox regression (outcome SARS-CoV-2 positive swab); B) multivariable logistic regression (outcome SARS-CoV-2 seroconversion).

Published
2022
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25. Analysis of Diagnostic Modalities in Hospital-admitted Patients Evaluated for COVID-19

Author

Gereke, Benedict, Friedl, Andree, Niemann, Tilo, Calligaris-Maibach, Romana, Schmid, Hans-Rudolf, Vanetta, Chiara, Rutishauser, Jonas, and Wiggli, Benedikt

Subjects
COVID-19, diagnostic modalities, CT scan, PCR, serology, Pharmacology, Cancer Research, Sensitivity and Specificity, Hospitals, General Biochemistry, Genetics and Molecular Biology, Hospitalization, Humans, Research Article, Aged, Retrospective Studies
Abstract

Background/Aim: To assess the diagnostic performance of reverse transcriptase polymerase chain reaction (RT-PCR), low-dose chest computed tomography (CT), and serological testing, alone and in combinations, as well as routine inflammatory markers in patients evaluated for COVID-19 during the first wave in early 2020. Patients and Methods: We retrospectively analyzed data of all patients who were admitted to the emergency department due to fever and/or respiratory symptoms. CT scans were rated using the COVID-19 Reporting and Data System (CO-RADS) suspicion score. True disease status (COVID-19 - positive vs. negative) was adjudicated by two independent clinicians. Receiver-operating characteristic curves and areas under the curves were calculated for inflammatory markers. Sensitivities and specificities were calculated for RT-PCR, CT, and serology alone, as well as the combinations of RT-PCR+CT, RT-PCR+serology, CT+serology, and all three modalities. Results: Of 221 patients with a median age of 72 years, 113 were classified as COVID-19 positive. Among 180 patients from which data on CT and RT-PCR were available, RT-PCR had the highest sensitivity to detect COVID-19 (0.87; 95%CI=0.78-0.93). Notably, the addition of CT in the analysis increased sensitivity to 0.89 (95%CI=0.8-0.94), but lowered specificity from 1 (95%CI=0.96-1) to 0.9 (95%CI=0.83-0.95). The combination of RT-PCR, CT and serology (n=60 patients with complete dataset) yielded a sensitivity of 0.83 (95%CI=0.61-0.94) and specificity of 0.86 (95%CI=0.72-0.93). Conclusion: RT-PCR was the best single test in patients evaluated for COVID-19. Conversely, the routine performance of chest CT adds little sensitivity and decreases specificity., In Vivo, 36 (3)

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2022
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26. Additional file 4 of Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms

Author

Deforth, Manja, Gebhard, Caroline E., Bengs, Susan, Buehler, Philipp K., Schuepbach, Reto A., Zinkernagel, Annelies S., Brugger, Silvio D., Acevedo, Claudio T., Patriki, Dimitri, Wiggli, Benedikt, Twerenbold, Raphael, Kuster, Gabriela M., Pargger, Hans, Schefold, Joerg C., Spinetti, Thibaud, Wendel-Garcia, Pedro D., Hofmaenner, Daniel A., Gysi, Bianca, Siegemund, Martin, Heinze, Georg, Regitz-Zagrosek, Vera, Gebhard, Catherine, and Held, Ulrike

Abstract

Additional file 4. Logistic regression model based on the ABE and ABESS variable selection, calculated on the total cohort.

Published
2022
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27. Symptoms Compatible With Long Coronavirus Disease (COVID) in Healthcare Workers With and Without Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection—Results of a Prospective Multicenter Cohort

Author

Strahm, Carol, primary, Seneghini, Marco, additional, Güsewell, Sabine, additional, Egger, Thomas, additional, Leal-Neto, Onicio, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Meier Kleeb, Dorette, additional, Möller, J Carsten, additional, Rieder, Philip, additional, Ruetti, Markus, additional, Rutz, Remus, additional, Schmid, Hans Ruedi, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Besold, Ulrike, additional, Kuster, Stefan P, additional, McGeer, Allison, additional, Risch, Lorenz, additional, Friedl, Andrée, additional, Schlegel, Matthias, additional, Schmid, Dagmar, additional, Vernazza, Pietro, additional, Kahlert, Christian R, additional, and Kohler, Philipp, additional

Published
2022
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29. Impact of respirator versus surgical masks on SARS-CoV-2 acquisition in healthcare workers: a prospective multicentre cohort

Author

Haller, Sabine, Güsewell, Sabine, Egger, Thomas, Scanferla, Giulia, Thoma, Reto, Leal-Neto, Onicio B, Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, Möller, J Carsten, Rieder, Philip, Rütti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P, McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andrée, Vernazza, Pietro, Kahlert, Christian R, and Kohler, Philipp

Subjects
Adult, Male, Adolescent, Health Personnel, 610 Medicine & health, Infectious and parasitic diseases, RC109-216, Kaplan-Meier Estimate, Young Adult, Surgical mask, Healthcare workers, Humans, Prospective Studies, Respiratory Protective Devices, Aerosol, Aged, Aerosols, Infection Control, Research, Masks, COVID-19, Middle Aged, Logistic Models, Seroconversion, Female, Respirator, Switzerland
Abstract

Background There is insufficient evidence regarding the role of respirators in the prevention of SARS-CoV-2 infection. We analysed the impact of filtering facepiece class 2 (FFP2) versus surgical masks on the risk of SARS-CoV-2 acquisition among Swiss healthcare workers (HCW). Methods Our prospective multicentre cohort enrolled HCW from June to August 2020. Participants were asked about COVID-19 risk exposures/behaviours, including preferentially worn mask type when caring for COVID-19 patients outside of aerosol-generating procedures. The impact of FFP2 on (1) self-reported SARS-CoV-2-positive nasopharyngeal PCR/rapid antigen tests captured during weekly surveys, and (2) SARS-CoV-2 seroconversion between baseline and January/February 2021 was assessed. Results We enrolled 3259 participants from nine healthcare institutions, whereof 716 (22%) preferentially used FFP2. Among these, 81/716 (11%) reported a SARS-CoV-2-positive swab, compared to 352/2543 (14%) surgical mask users; seroconversion was documented in 85/656 (13%) FFP2 and 426/2255 (19%) surgical mask users. Adjusted for baseline characteristics, COVID-19 exposure, and risk behaviour, FFP2 use was non-significantly associated with decreased risk for SARS-CoV-2-positive swab (adjusted hazard ratio [aHR] 0.8, 95% CI 0.6–1.0) and seroconversion (adjusted odds ratio [aOR] 0.7, 95% CI 0.5–1.0); household exposure was the strongest risk factor (aHR 10.1, 95% CI 7.5–13.5; aOR 5.0, 95% CI 3.9–6.5). In subgroup analysis, FFP2 use was clearly protective among those with frequent (> 20 patients) COVID-19 exposure (aHR 0.7 for positive swab, 95% CI 0.5–0.8; aOR 0.6 for seroconversion, 95% CI 0.4–1.0). Conclusions Respirators compared to surgical masks may convey additional protection from SARS-CoV-2 for HCW with frequent exposure to COVID-19 patients. Supplementary Information The online version contains supplementary material available at 10.1186/s13756-022-01070-6.

Published
2021

30. Sex versus gender-related characteristics: which predicts clinical outcomes of acute COVID-19?

Author

Gebhard, Caroline E., Hamouda, Nadia, Gebert, Pimrapat, Regitz-Zagrosek, Vera, Gebhard, Catherine, on behalf of the COGEN Investigators, Bengs, Susan, Gysi, Bianca, Dussault-Cloutier, Arnaud, Buehler, Karl Philipp, Schuepbach, Reto A., Zinkernagel, Annelies S., Brugger, Silvio D., Acevedo, Claudio, Patriki, Dimitri, Wiggli, Benedikt, Beer, Jürg H., Friedl, Andrée, Twerenbold, Raphael, and Kuster, Gabriela M.

Published
2022
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31. Symptoms compatible with long-COVID in healthcare workers with and without SARS-CoV-2 infection – results of a prospective multicenter cohort

Author

Strahm, Carol, primary, Seneghini, Marco, additional, Güsewell, Sabine, additional, Egger, Thomas, additional, Leal, Onicio, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Kleeb, Dorette Meier, additional, Möller, J. Carsten, additional, Rieder, Philip, additional, Ruetti, Markus, additional, Rutz, Remus, additional, Schmid, Hans-Ruedi, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Besold, Ulrike, additional, Kuster, Stefan P., additional, McGeer, Allison, additional, Risch, Lorenz, additional, Friedl, Andrée, additional, Schlegel, Matthias, additional, Schmid, Dagmar, additional, Vernazza, Pietro, additional, Kahlert, Christian R., additional, and Kohler, Philipp, additional

Published
2021
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33. Understanding the Impact of Sociocultural Gender on Post-acute Sequelae of COVID-19: a Bayesian Approach

Author

Gebhard, Caroline E., primary, Sütsch, Claudia, additional, Bengs, Susan, additional, Todorov, Atanas, additional, Deforth, Manja, additional, Buehler, Karl Philipp, additional, Meisel, Alexander, additional, Schuepbach, Reto A., additional, Zinkernagel, Annelies S., additional, Brugger, Silvio D., additional, Acevedo, Claudio, additional, Patriki, Dimitri, additional, Wiggli, Benedikt, additional, Gysi, Bianca, additional, Beer, Jürg H., additional, Friedl, Andrée, additional, Twerenbold, Raphael, additional, Kuster, Gabriela M., additional, Pargger, Hans, additional, Tschudin-Sutter, Sarah, additional, Schefold, Joerg C., additional, Spinetti, Thibaud, additional, Henze, Chiara, additional, Pasqualini, Mina, additional, Sager, Dominik F., additional, Mayrhofer, Lilian, additional, Grieder, Mirjam, additional, Tontsch, Janna, additional, Franzeck, Fabian, additional, Wendel Garcia, Pedro D., additional, Hofmaenner, Daniel A., additional, Scheier, Thomas, additional, Bartussek, Jan, additional, Haider, Ahmed, additional, Grämer, Muriel, additional, Mikail, Nidaa, additional, Rossi, Alexia, additional, Zellweger, Núria, additional, Opic, Petra, additional, Portmann, Angela, additional, von Känel, Roland, additional, Pazhenkottil, Aju P., additional, Messerli, Michael, additional, Buechel, Ronny R., additional, Kaufmann, Philipp A., additional, Treyer, Valerie, additional, Siegemund, Martin, additional, Held, Ulrike, additional, Regitz-Zagrosek, Vera, additional, and Gebhard, Catherine, additional

Published
2021
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34. Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent Covid-19 – a prospective multicentre cohort study

Author

Kohler, Philipp, primary, Güsewell, Sabine, additional, Seneghini, Marco, additional, Egger, Thomas, additional, Leal, Onicio, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Möller, J. Carsten, additional, Rieder, Philip, additional, Ruetti, Markus, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Besold, Ulrike, additional, Kuster, Stefan P., additional, McGeer, Allison, additional, Risch, Lorenz, additional, Friedl, Andrée, additional, Vernazza, Pietro, additional, and Kahlert, Christian R., additional

Published
2021
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35. Use of respirator vs. surgical masks in healthcare personnel and its impact on SARS-CoV-2 acquisition – a prospective multicentre cohort study

Author

Haller, Sabine, primary, Güsewell, Sabine, additional, Egger, Thomas, additional, Scanferla, Giulia, additional, Thoma, Reto, additional, Leal-Neto, Onicio B., additional, Flury, Domenica, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Möller, J. Carsten, additional, Rieder, Philip, additional, Ruetti, Markus, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Besold, Ulrike, additional, Kuster, Stefan P., additional, McGeer, Allison, additional, Risch, Lorenz, additional, Schlegel, Matthias, additional, Friedl, Andrée, additional, Vernazza, Pietro, additional, Kahlert, Christian R., additional, and Kohler, Philipp, additional

Published
2021
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36. Understanding the Impact of Sociocultural Gender on Post-acute Sequelae of COVID-19: a Bayesian Approach

Author

Gebhard, Caroline E, Sütsch, Claudia, Bengs, Susan, Deforth, Manja, Buehler, Karl Philipp, Hamouda, Nadia, Meisel, Alexander, Schuepbach, Reto A, Zinkernagel, Annelies S, Brugger, Silvio D, Acevedo, Claudio, Patriki, Dimitri, Wiggli, Benedikt, Beer, Jürg H, Friedl, Andrée, Twerenbold, Raphael, Kuster, Gabriela M, Pargger, Hans, Tschudin-Sutter, Sarah, Schefold, Joerg C, Spinetti, Thibaud, Dussault-Cloutier, Arnaud, Henze, Chiara, Pasqualini, Mina, Sager, Dominik F, Mayrhofer, Lilian, Grieder, Mirjam, Tontsch, Janna, Franzeck, Fabian, Wendel Garcia, Pedro D, et al, and University of Zurich

Subjects
610 Medicine & health, 10181 Clinic for Nuclear Medicine
Published
2021
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37. Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among hospital workers - A multicentre cross-sectional study

Author

Kahlert, Christian R, Persi, Raphael, Güsewell, Sabine, Egger, Thomas, Leal-Neto, Onicio B; https://orcid.org/0000-0001-5785-1867, Sumer, Johannes, Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, Möller, J Carsten, Rieder, Philip, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Albrich, Werner C, Babouee Flury, Baharak, Besold, Ulrike, Fehr, Jan, Kuster, Stefan P, McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andrée, Vernazza, Pietro, Kohler, Philipp, Kahlert, Christian R, Persi, Raphael, Güsewell, Sabine, Egger, Thomas, Leal-Neto, Onicio B; https://orcid.org/0000-0001-5785-1867, Sumer, Johannes, Flury, Domenica, Brucher, Angela, Lemmenmeier, Eva, Möller, J Carsten, Rieder, Philip, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Albrich, Werner C, Babouee Flury, Baharak, Besold, Ulrike, Fehr, Jan, Kuster, Stefan P, McGeer, Allison, Risch, Lorenz, Schlegel, Matthias, Friedl, Andrée, Vernazza, Pietro, and Kohler, Philipp

Abstract

OBJECTIVES Protecting healthcare workers (HCWs) from coronavirus disease-19 (COVID-19) is critical to preserve the functioning of healthcare systems. We therefore assessed seroprevalence and identified risk factors for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) seropositivity in this population. METHODS Between 22 June 22 and 15 August 2020, HCWs from institutions in northern/eastern Switzerland were screened for SARS-CoV-2 antibodies. We recorded baseline characteristics, non-occupational and occupational risk factors. We used pairwise tests of associations and multivariable logistic regression to identify factors associated with seropositivity. RESULTS Among 4664 HCWs from 23 healthcare facilities, 139 (3%) were seropositive. Non-occupational exposures independently associated with seropositivity were contact with a COVID-19-positive household (adjusted OR 59, 95% CI 33-106), stay in a COVID-19 hotspot (aOR 2.3, 95% CI 1.2-4.2) and male sex (aOR 1.9, 95% CI 1.1-3.1). Blood group 0 vs. non-0 (aOR 0.5, 95% CI 0.3-0.8), active smoking (aOR 0.4, 95% CI 0.2-0.7), living with children <12 years (aOR 0.3, 95% CI 0.2-0.6) and being a physician (aOR 0.2, 95% CI 0.1-0.5) were associated with decreased risk. Other occupational risk factors were close contact to COVID-19 patients (aOR 2.7, 95% CI 1.4-5.4), exposure to COVID-19-positive co-workers (aOR 1.9, 95% CI 1.1-2.9), poor knowledge of standard hygiene precautions (aOR 1.9, 95% CI 1.2-2.9) and frequent visits to the hospital canteen (aOR 2.3, 95% CI 1.4-3.8). DISCUSSION Living with COVID-19-positive households showed the strongest association with SARS-CoV-2 seropositivity. We identified several potentially modifiable work-related risk factors, which might allow mitigation of the COVID-19 risk among HCWs. The lower risk among those living with children, even after correction for multiple confounders, is remarkable and merits further study.

Published
2021

38. Prediction of Patient Management in COVID-19 Using Deep Learning-Based Fully Automated Extraction of Cardiothoracic CT Metrics and Laboratory Findings

Author

Weikert, Thomas, primary, Rapaka, Saikiran, additional, Grbic, Sasa, additional, Re, Thomas, additional, Chaganti, Shikha, additional, Winkel, David J., additional, Anastasopoulos, Constantin, additional, Niemann, Tilo, additional, Wiggli, Benedikt J., additional, Bremerich, Jens, additional, Twerenbold, Raphael, additional, Sommer, Gregor, additional, Comaniciu, Dorin, additional, and Sauter, Alexander W., additional

Published
2021
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39. Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among Hospital Workers – a multicentre cross-sectional study

Author

Kahlert, Christian R., primary, Persi, Raphael, additional, Güsewell, Sabine, additional, Egger, Thomas, additional, Leal-Neto, Onicio B., additional, Sumer, Johannes, additional, Flury, Domenica, additional, Brucher, Angela, additional, Lemmenmeier, Eva, additional, Möller, J. Carsten, additional, Rieder, Philip, additional, Stocker, Reto, additional, Vuichard-Gysin, Danielle, additional, Wiggli, Benedikt, additional, Albrich, Werner C., additional, Flury, Baharak Babouee, additional, Besold, Ulrike, additional, Fehr, Jan, additional, Kuster, Stefan P., additional, McGeer, Allison, additional, Risch, Lorenz, additional, Schlegel, Matthias, additional, Friedl, Andrée, additional, Vernazza, Pietro, additional, and Kohler, Philipp, additional

Published
2020
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44. Additional file 3 of Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study

Author

Kohler, Philipp, Güsewell, Sabine, Seneghini, Marco, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Möller, J. Carsten, Rieder, Philip, Ruetti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, and Kahlert, Christian R.

Subjects
Data_FILES, 3. Good health
Abstract

Additional file 3.

45. Additional file 3 of Impact of baseline SARS-CoV-2 antibody status on syndromic surveillance and the risk of subsequent COVID-19—a prospective multicenter cohort study

Author

Kohler, Philipp, Güsewell, Sabine, Seneghini, Marco, Egger, Thomas, Leal, Onicio, Brucher, Angela, Lemmenmeier, Eva, Möller, J. Carsten, Rieder, Philip, Ruetti, Markus, Stocker, Reto, Vuichard-Gysin, Danielle, Wiggli, Benedikt, Besold, Ulrike, Kuster, Stefan P., McGeer, Allison, Risch, Lorenz, Friedl, Andrée, Schlegel, Matthias, Vernazza, Pietro, and Kahlert, Christian R.

Subjects
Data_FILES, 3. Good health
Abstract

Additional file 3.

47. ["And zebras do exist after all"! : Pulmonary nocardiosis: case series and overview].

Author

Schröder J, Calligaris-Maibach R, Beer HJ, and Wiggli B

Subjects
Humans, Anti-Bacterial Agents therapeutic use, Lung Diseases diagnosis, Nocardia Infections diagnosis
Abstract

Nocardiosis is a rare disease that occurs primarily in patients with predisposing factors (immunosuppression/chronic lung disease). It is caused by aerobic, Gram-positive bacteria that are ubiquitous in soil. Cutaneous and pulmonary manifestations are most common, but disseminated forms also occur. In terms of treatment, long-term antibiotic therapy is usually necessary. The prognosis for the cutaneous or pulmonary form is generally good., (© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)

Published
2024
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48. Impact of sex and gender on post-COVID-19 syndrome, Switzerland, 2020.

Author

Gebhard CE, Sütsch C, Gebert P, Gysi B, Bengs S, Todorov A, Deforth M, Buehler PK, Meisel A, Schuepbach RA, Zinkernagel AS, Brugger SD, Acevedo C, Patriki D, Wiggli B, Beer JH, Friedl A, Twerenbold R, Kuster GM, Pargger H, Tschudin-Sutter S, Schefold JC, Spinetti T, Henze C, Pasqualini M, Sager DF, Mayrhofer L, Grieder M, Tontsch J, Franzeck FC, Wendel Garcia PD, Hofmaenner DA, Scheier T, Bartussek J, Haider A, Grämer M, Mikail N, Rossi A, Zellweger N, Opić P, Portmann A, von Känel R, Pazhenkottil AP, Messerli M, Buechel RR, Kaufmann PA, Treyer V, Siegemund M, Held U, Regitz-Zagrosek V, and Gebhard C

Subjects
Female, Humans, Male, Adult, Middle Aged, Post-Acute COVID-19 Syndrome, Switzerland epidemiology, Prospective Studies, SARS-CoV-2, Disease Progression, COVID-19 epidemiology
Abstract

BackgroundWomen are overrepresented among individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). Biological (sex) as well as sociocultural (gender) differences between women and men might account for this imbalance, yet their impact on PASC is unknown.AimWe assessed the impact of sex and gender on PASC in a Swiss population.MethodOur multicentre prospective cohort study included 2,856 (46% women, mean age 44.2 ± 16.8 years) outpatients and hospitalised patients with PCR-confirmed SARS-CoV-2 infection.ResultsAmong those who remained outpatients during their first infection, women reported persisting symptoms more often than men (40.5% vs 25.5% of men; p < 0.001). This sex difference was absent in hospitalised patients. In a crude analysis, both female biological sex (RR = 1.59; 95% CI: 1.41-1.79; p < 0.001) and a score summarising gendered sociocultural variables (RR = 1.05; 95% CI: 1.03-1.07; p < 0.001) were significantly associated with PASC. Following multivariable adjustment, biological female sex (RR = 0.96; 95% CI: 0.74-1.25; p = 0.763) was outperformed by feminine gender-related factors such as a higher stress level (RR = 1.04; 95% CI: 1.01-1.06; p = 0.003), lower education (RR = 1.16; 95% CI: 1.03-1.30; p = 0.011), being female and living alone (RR = 1.91; 95% CI: 1.29-2.83; p = 0.001) or being male and earning the highest income in the household (RR = 0.76; 95% CI: 0.60-0.97; p = 0.030).ConclusionSpecific sociocultural parameters that differ in prevalence between women and men, or imply a unique risk for women, are predictors of PASC and may explain, at least in part, the higher incidence of PASC in women. Once patients are hospitalised during acute infection, sex differences in PASC are no longer evident.

Published
2024
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49. Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study).

Author

Kohler P, Babouee Flury B, Güsewell S, Egger T, Leal O, Brucher A, Lemmenmeier E, Meier Kleeb D, Möller JC, Ortner M, Rieder P, Ruetti M, Schmid HR, Stocker R, Vuichard-Gysin D, Speer O, Wiggli B, Besold U, McGeer A, Risch L, Friedl A, Schlegel M, Vernazza P, Kahlert CR, and Kuster SP

Subjects
Humans, SARS-CoV-2, Breakthrough Infections, Dizziness, Prospective Studies, Vaccination, Health Personnel, Pain, COVID-19 prevention & control, Vaccines
Abstract

The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction., Competing Interests: No conflict of interest was declared., (© 2023 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)

Published
2023
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50. A rare and dangerous hand infection caused by Francisella tularensis after a mouse bite.

Author

Mijuskovic B, Wiggli B, and Kaempfen A

Subjects
Animals, Anti-Bacterial Agents therapeutic use, Debridement, Hand surgery, Hospitalization, Humans, Infusions, Intravenous, Male, Piperacillin, Soft Tissue Infections therapy, Tazobactam, Tularemia drug therapy, Young Adult, Bites and Stings complications, Hand microbiology, Mice microbiology, Soft Tissue Infections microbiology, Tularemia diagnosis
Published
2018
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