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To investigate the characteristics of gene mutation in elderly patients with acute myeloid leukemia (AML) and its effect on prognosis.The clinical and laboratorial characteristics of 54 AML patients (≥60 years old) in Department of Hematology, Tangdu Hospital were analyzed retrospectively during April 2016 to October 2019. Thirty-four AML/myelodysplastic syndrome/myeloproliferative neoplasm related mutant genes were detected by second-generation sequencing technology, and their clinical characteristics, treatment effect, and influence on prognosis were analyzed.All the patients received DAC+CAG induction treatment, after 1-2 couses of treatment, 36 cases (66.7%) achieved complete response, with a total effective rate of 75.9%, and the median survival time was 17 months. The most frequent mutant genes were TET2 (33.3%), CEBPA (31.5%), DNMT3A (18.5%), ASXL1 (16.7%), NRAS (14.8%), RUNX1 (14.8%), FLT3-ITD (12.9%), TP53 (12.9%), NPM1 (12.9%), and IDH2 (12.9%). Among 7 patients with TP53 mutation, 6 cases obtained complete response after 1-2 courses of induction treatment, but there was no statistically significant difference in the effect on prognosis. Patients with FLT3-ITD and NRAS mutations had shorter overall survival time compared with who had no mutation (P=0.47, P=0.48). Multivariate analysis showed that FLT3-ITD and NRAS mutations were poor prognostic factors.The incidence of TET2 gene mutation is high in elderly AML patients. AML patients with TET2 and TP53 mutations may benefit from Decitabine-based chemotherapy. However, patients with FLT3-ITD and NRAS mutations have a short survival time, and may have a poor prognosis.老年急性髓系白血病患者的基因突变特征及预后分析.探讨老年急性髓系白血病患者的基因突变特征及对预后的影响.回顾性分析2016年4月至2019年10月在空军军医大学唐都医院血液科接受治疗的54例年龄≥60岁初治急性髓系白血病患者的临床资料，采用二代测序技术检测34个急性髓系白血病/骨髓增生异常综合征/骨髓增殖性肿瘤相关突变基因，分析其临床特征、治疗效果及对预后的影响.54例患者均采用DAC+CAG方案诱导治疗，经过1-2个疗程治疗达完全缓解者36例（66.7%），总有效率75.9%，中位生存时间为17个月。突变频率较高的基因依次为TET2（33.3%）、CEBPA（31.5%）、DNMT3A （18.5%）、ASXL1（16.7%）、NRAS（14.8%）、RUNX1（14.8%）、FLT3-ITD（12.9%）、TP53（12.9%）、NPM1（12.9%）、 IDH2（12.9%）。7例伴TP53突变的患者中6例经1-2个疗程诱导治疗获得完全缓解，但对预后的影响无统计学差异。伴FLT3-ITD和NRAS基因突变患者的总生存时间均短于无突变的患者（P=0.47，P=0.48）。多因素分析显示，FLT3-ITD及NRAS基因突变是预后不良因素.老年急性髓系白血病患者TET2基因突变发生率高。伴TET2和TP53基因突变的老年急性髓系白血病患者可从地西他滨中获益，而伴FLT3-ITD、NRAS基因突变的患者生存时间短，可能预后不良.

In this paper, a dual-ligand design strategy is demonstrated to modulate the performance of the electronically conductive metalorganic frameworks (EC-MOFs) thin film with a spray layer-by-layer assembly method. The thin film not only can be precisely prepared in nanometer scale (20–70 nm), but also shows the pin-hole-free smooth surface. The high quality nano-film of 2,3,6,7,10,11-hexaiminotriphenylene (HITP) doped Cu-HHTP enables the precise modulation of the chemiresistive sensitivity and selectivity. Selectivity improvement over 220% were realized for benzene vs. NH3, as well as enhanced response and recovery properties. In addition, the selectivity of the EC-MOF thin film sensors toward other gases (e.g. triethylamine, methane, ethylbenzene, hydrogen, butanone, and acetone) vs. NH3 at room temperature is also discussed.

To investigate the clinical characteristics and prognosis of acute myeloid leukemia(AML) patients with ASXL1 mutation.The clinical data of 229 newly diagnosed AML patients treated in our hospital from April 2016 to October 2019 were analyzed retrospectively. The next-generation sequencing technology was used to detect gene mutations in all the patients, the clinical characteristics of the patients with ASXL1 mutation were analyzed.ASXL1 gene mutation was detected out in 45 patients(19.6%). Among these patients, the frameshift mutation (n=22,48.9%) was most common, followed by missense mutation (n=15, 33.3%) and nonsense mutation (n=8,17.8%), respectively, all of them were located at exon 12. The median mutation rate was 32.47%(range, 2.74%-53.50%). The median age of the patients with ASXL1 mutation was 54(range, 14-74) years old, and most of the patients were male, and most of them with the history of MDS or MPN, and low white blood cell count at the initial diagnosed (P0.05). Patients with ASXL1 mutation showed a lower CR rate than that of without ASXL1 mutation. Patients with or without ASXL1 mutation showed a statistically significant difference in survival at 20 months (P=0.042), while there was no significant difference between the patients in the two groups over 20 months (P=0.505). All the 6 patients with ASXL1 mutation in low-risk group were survived, while the median OS time was 16 months in the high-risk group(P=0.034). Multivariate analysis showed that the history of MDS or MPN and CR rate from induction therapy were the independent risk factors affecting survival of the patients.Frameshift mutation is commonly in AML patients with ASXL1 gene mutation, and ASXL1 mutation were more often in men, the history of MDS or MPN, and low white blood cell count. The CR rate of the patients with ASXL1 mutation was lower than that of the AML patients without ASXL1 mutations, AML patients with ASXL1 mutation showed poor short-term efficacy, but there was no significant difference between the two groups in long-term survival over 20 months.伴ASXL1基因突变的急性髓系白血病患者的临床特征及预后分析.探讨伴有ASXL1基因突变的急性髓系白血病（AML）患者的临床特征及预后.回顾性分析2016年4月至2019年10月就诊于空军军医大学唐都医院血液科的初诊AML患者229例的临床资料，采用二代测序技术进行基因突变检测，分析ASXL1基因突变患者的临床特征并进行预后分析.共45例（19.6%）患者检测到ASXL1基因突变，移码突变22例（48.9%），错义突变15例（33.3%），无义突变8例（17.8%），均位于12号外显子。中位突变比例为32.47%（2.74%-53.50%）。伴有ASXL1基因突变的患者中位年龄为54（14-74）岁，以男性患者多见、且前期多有MDS或MPN病史、初诊时外周血白细胞数不高。伴有ASXL1突变组的患者诱导化疗完全缓解率低于无ASXL1突变的患者。伴或不伴ASXL1突变的患者在20个月内的生存具有统计学差异（P=0.042），而20个月以上的两组患者OS时间无差异（P=0.505）。伴ASXL1基因突变患者中，预后良好者6例全部存活，预后不良组中位OS时间16个月（P＝0.034）。多因素分析显示，前期血液病史及诱导治疗是否获得CR是影响预后的独立不良因素.伴ASXL1突变的AML患者中以移码突变常见。ASXL1突变多见于男性，起病白细胞不高，且易存在前期血液病史。伴ASXL1突变AML患者的CR率低于无ASXL1突变组，且短期疗效更差（≤20个月），但20个月以上的长期生存无显著差异.

Adiponectin is a potent vascular protective molecule. Recent findings have suggested adiponectin resistance during early diabetes. However, the molecular mechanisms responsible remain unidentified. Here, we took an unbiased approach to identify whether hyperlipidemic plasma molecules exist that bind and inhibit adiponectin function, contributing to adiponectin resistance and diabetic vascular injury.Adult rats were randomly assigned to receive either a normal or a high-fat diet for 8 weeks. Plasma was co-immunoprecipitated with anti-APN antibody and analyzed by mass spectrometry. The APN binding molecules and their effect upon APN biological activity were determined.As expected, the high-fat-diet increased plasma triglyceride, total cholesterol, and low-density lipoprotein. Importantly, the circulating APN level was significantly increased at this time point. Mass spectrometry identified 18 proteins with increased APN binding in hyperlipidemic plasma, among which four proteins critical in lipid metabolism, including apolipoprotein A1 (APOA1), APOA4, APOC1, and paraoxonase 1, were further investigated. Incubating recombinant APN with APOA1 markedly (P 0.01), and incubating with APOC1 significantly (P 0.05), inhibited APN activity as evidenced by the reduced AMPK activation in HUVECs. APOA4 and paraoxonase 1 incubation had no effect upon APN activity. Finally, plasma APOA1 was significantly increased (P 0.05) in hyperlipidemic plasma compared with the control plasma.It was demonstrated for the first time that increased APOA1 and APOC1 in hyperlipidemic plasma binds and inhibits APN activity. This result not only identifies a novel molecular mechanism responsible for adiponectin resistance during early stage diabetes, but also provides additional new insight into the diverse/controversial (protective and harmful) functions of high-density lipoprotein.

Eight different species were identified among the 79 isolates. The most prevalentThe taxonomy, antibiotic resistance, and pathogenicity of different

Both the growth and survival of landscape plants are difficult due to the harsh natural conditions in coastal areas of southern China. Many plants suffer from symptoms of salt damage. Different from the damages by salt in the soil, the symptoms of windblown salt are damage to young shoots and leaves. Plants at the windward side are damaged more than the leeward side. These cha-racteristics imply that the damage is due to salt in aerosols instead of salt in the soil. To test this hypothesis, we measured plant growth, soil and climate factors in 24 frontline coastal counties and cities of China. The results showed that the first-line coastal plants showed strong symptoms of salt damage, especially in the Taiwan Strait area (85.4% belonged to desalinized soil), and that the damage level was highly correlated with wind speed. Our results confirmed that aerosol salt is the major cause of plant damage in the coastal areas of southern China. We constructed the first distribution map of salt damage along frontline coastal regions of southern China and proposed methods for diagnosing aerosol salt damage. Selecting and configuring aerosol salt-tolerant plants, greening engineering measures, and follow-up maintenance were suggested for improving the overall effect and level of landscaping in the coastal areas of southern China.南方滨海地区自然条件恶劣,植物长势差、存活困难,相当一部分绿化植物表现出一定程度的盐害症状。但这些植物的盐害症状不同于常规的土壤盐害,表现出幼芽幼叶首先受害、迎风面受害症状重于背风面等,推测植物受害原因并非土壤含盐量过高。本研究在植物长势评估的基础上结合土壤及气候分析,对中国南方滨海地区一线海岸24个县市开展了调研。结果表明: 一线海岸植物表现出较强的盐害症状,尤其是台湾海峡区域,但85.4%属脱盐土,且植物盐害等级与风速呈极显著相关,因此提出南方滨海地区绿化植物盐害主要原因是盐雾危害。绘制了首张南方滨海地区一线海岸植物盐害等级分布图,提出了一套植物盐雾危害的诊断方法,并就耐盐雾植物的筛选与配置、绿化工程措施及后期养护等提供了一系列建议,以期切实提高南方滨海地区园林绿化的整体景观效果和水平。.

For storage and recovery requirements on large-scale seismic waveform data of the National Earthquake Data Backup Center (NEDBC), a distributed cluster processing model based on Kafka message queues is designed to optimize the inbound efficiency of seismic waveform data stored in HBase at NEDBC. Firstly, compare the characteristics of big data storage architectures with that of traditional disk array storage architectures. Secondly, realize seismic waveform data analysis and periodic truncation, and write HBase in NoSQL record form through Spark Streaming cluster. Finally, compare and test the read/write performance of the data processing process of the proposed big data platform with that of traditional storage architectures. Results show that the seismic waveform data processing architecture based on Kafka designed and implemented in this paper has a higher read/write speed than the traditional architecture on the basis of the redundancy capability of NEDBC data backup, which verifies the validity and practicability of the proposed approach.

To explore the practicability, feasibility and wound aesthetics of Gimmi ultra micro instrument in laparoscopic cholecystectomy. To retrospective analysis the clinical data of 75 patients undergoing elective surgery for gallbladder stones with chronic cholecystitis, gallbladder polyps and chronic cholecystitis who were admitted to the Department of General Surgery, Taikang Xianlin Drum Tower Hospital, Nanjing University School of Medicine, from October 2019 to October 2020. Among them, 35 cases used gimmi ultra micro instrument to remove the gallbladder (ultra-minimally invasive group) and 40 cases used the traditional three-hole method to remove the gallbladder (traditional group). The operation time, blood loss during operation, postoperative ventilation time, pain scores on the 1st and 3rd d after surgery, shortterm complications such as postoperative bleeding and bile leakage, incision scar satisfaction score, total hospital stay were compared between the two groups of patients and other indicators. Both groups of patients recovered and discharged without any bleeding or bile leakage after operation. The operation time of the ultra-minimally invasive group was slightly longer than that of the traditional group. There was no significant difference in the amount of blood loss, postoperative ventilation time and incision infection (p>0.05). The ultra-minimally invasive group was better than the traditional group in total hospital stay (p

La0.8Sr0.2Mn1−xCoxO3 (x = 0, 0.2) polycrystalline samples were prepared by solid-state reaction, and their structural, Griffiths phase, magnetic entropy change, critical behavior, and electrical transport properties were systematically investigated. The results show that all polycrystalline samples are rhombohedral symmetry structures; the Griffiths phase exists above the low-temperature magnetic transition temperature (TC2) of the two samples; the magnetic field is applied to the La0.8Sr0.2Mn1−xCoxO3 (x = 0, 0.2) samples. The maximum magnetic entropy change ΔSmax for 7 T is − 2.28 and − 2.36 J/(kg K), respectively. The doping of Co makes ΔSmax increase, and an obvious negative entropy change occurs at low temperature and low field; the critical behavior of La0.8Sr0.2MnO3 (LSMO) fits best with the mean field model, and the critical behavior of the sample after doping with the 3D Heisenberg model fits best; LSMO is a semiconductor material, and the metal insulator transition appears near the low-temperature magnetic transition temperature (TC2) when the Co element doping amount reaches 0.2. The conductivity of the two samples in the high-temperature region satisfies the small polaron model.

We report computational and experimental studies (i) on the Fermi level (EF) pinning phenomena in weakly interacting electrode-organic semiconductor systems with pentacene, N, N-Di(naphthalene-l-yl)-N, N’-diphenyl-benzidine (α-NPD) and Poly(9,9-dioctylfluorene-alt-benzothiadiazole) (F8BT)], and (ii) to elucidate a common reason of the pinning phenomena which have been widely observed for various organic materials on inert electrode surfaces. For (i), the computed results on the electrode-dependence of EF-HOMO and EF-LUMO distance agreed excellently with UPS and Kelvin-probe results. For (ii) we found theoretically that the pinning phenomena occur at systems even without any electronic states in the HOMO-LUMO gap, and thereby indicate that this is a universal Fermi-level pinning-like phenomena for various band gap materials, even if specific interface states do not exist upon contact. We further obtained for Gaussian-distributed HOMO and LUMO that the minimal hole and electron injection barriers are quantitatively determined by degree of standard deviations of HOMO and LUMO bands, which are in excellent agreement with the experimental results. Furthermore, our results provide a guideline for approaching the “zero” injection barriers.

The mechanical properties of resin-bonded sand mixtures at high temperatures significantly affect the quality of casting. However, the existing instruments for high-temperature performances testing mainly focus on inorganic binder-bonded sands no matter the test items or the atmospheric protection, while the instrumentss specially designed for resin-bonded sand are not yet available. A new instrument for testing the high-temperature performance of resin sand was designed including the confirmation of the testing parameters, loading, measurement and control systems, and the design of the frame shape and heating furnace. This instrument can test the compressive strength, heat tolerance time and restraining load of phenol-formaldehyde resin coated sand, self-hardened furan resin sand, and trimethylamine (TEA)-based resin bonded sand at high temperatures. The developed instrument has a high accuracy offering smaller than 0.3% deviation at a full scale in the measurement of the high temperature compressive strength and the restraining load over the range of 0–6.8 MPa and 0–2,000 N, respectively. The high temperature heat tolerance time range is 0–300 s and its measurement accuracy is ±1 s.

High temperature compressive strength is one of the most important performances of resin sand; its value directly concerns the quality of castings. In order to seek the best testing method of resin sand high temperature compressive strength, a self-developed instrument was used to carry out experiments, and the sample shape and size were designed and studied. The results show that a hollow cylinder sample can reflect the strength difference of different resin sands better than a solid cylinder sample, and its data is stable. The experiments selected Φ20/5×30 mm as the size of the hollow cylinder samples. The high temperature compressive strengths of phenol-formaldehyde resin coated sand, furan resin self-setting sand, and TEA resin sand were each tested. For the resin sand used for cast steel and cast iron, 1,000 oC was selected as the test temperature; for the resin sand used for cast non-ferrous alloy, 800 oC was selected as the test temperature; and for all the resin sand samples, 1 min was selected as the holding time. This testing method can truthfully reflect the high temperature performance of three kinds of resin sand; it is reproducible, and the variation coefficients of test values are under 10%.

To investigate the safety and efficacy of decitabine combined with CAG regimen in the treat-ment of newly diagnosed elderly patients with acute myeloid leukemia(AML).Fourty-nine patients with newly diagnosed acute myeloid leukemia (except M3) who were admitted to our hospital were selected. All the patients were older than 50 years old, and allogeneic hematopoietic stem cell transplantation could not be performed for various reasons. Decitabine-based chemotherapy regimens were used during induction therapy including single decitabine therapy(DAC), decitabine combined with CAG regimen(DAC-CAG) and decitabine combined with HAAG regimen(DAC-HAAG). Most of patients continued to use the original treatment after complete remission, while others were given the standard "3+7" regimen chemotherapy. A total of 2-4 courses of treatment was conducted in the majority of patients.All of the 49 patients completed the induction therapy, in which 26 cases achieved complete remission(CR), 7 cases achieved partial remission(PR) and no response(NR) existed in 16 cases. The complete remission and the overall response rate(ORR) were 53% and 67% respectively. The overall response rate of DAC group, DAC-CAG group and DAC-HAAG group were 17%, 77% and 63% respectively. 14 patients were infected and 1 patients died of pulmonary infection during the induction therapy. The median number of suspended red blood cells and platelet infused were 9 units and 69 units respectively. Neutrophil recovery time was 15.1 days while the platelet recovery time was 20.1 days during the induction therapy. The mean follow-up time was 21 months. Overall survival(OS) was 75% at 6 months, 30% at 1 year, and 26% at 2 year, while disease-free survival(DFS) was 83% at 3 months, 54% at 1 year, and 47% at 2 year. The induction therapy could reach CR that was an independent prognostic factor, however, the initial white blood cell count, platelet count, age, chemotherapy regimen, prognostic stratification and whether complical by pnenmonia during chemotherapy were not independent prognostic factors.The induction efficacy of decitabine combined with chemotherapy is superior to that of decitabine alone. The outcome of induction chemotherapy is an independent prognostic factor, however, the high white blood cell count, poor karyotype, complications and AML with myelodysplasia-related changes do not affect long-term survival. DAC-CAG regimen is effective and have relatively few adverse reactions in AML. It is suitable for the patients who are ineligible for conventional chemotherapy.

An adaptive control strategy based on a fuzzy logic system by introducing a nonzero time-varying parameter is studied for an n-link manipulator system with the condition of a complex environment. At the beginning, a universal approximator with a one time-varying parameter is proposed based on the analysis of the fuzzy logic system, which is utilized to equalize uncertainties in robot manipulators with time-varying output constraints. The novel design method is used to reduce greatly the online learning computation burden compared with traditional fuzzy adaptive control. The output and the position of robotic manipulators are constrained with time-varying, a good tracking performance can be guaranteed with the condition of unknown dynamics of robot manipulators, and the violation of constraints can be conquered by the analysis based on the barrier Lyapunov function. A switching adaptive control is proposed to extend the semiglobal stability to global stability. Effectiveness of the approach is demonstrated by simulation results.

A variety of beneficial pharmacological activities have been reported for dihydromyricetin (DMY), however, its oral bioavailability is poor and the intestinal absorption profiles of DMY remains unknown. The aim of this study was to investigate the uptake and transport mechanism of DMY in human intestinal Caco-2 cells. DMY was detected using a liquid chromatography-tandem mass spectrometry method. Several factors including time, concentration, pH, temperature and efflux transporters were systematically evaluated. DMY was poorly absorbed by a passive diffusion mechanism. The uptake and transport of DMY were time and concentration dependent. Interestingly, decreasing the pH from 8.0 to 6.0 markedly enhanced the DMY uptake, but didn't significantly affect its bidirectional transport. Efflux transporters, multidrug resistance protein 2 and breast cancer resistance protein also influenced the DMY uptake and transport processes. This work details the uptake and transport characteristics of DMY and provides basis for future study.This study elucidated the uptake and transport characteristics of dihydromyricetin (DMY). DMY was poorly absorbed by a passive diffusion mechanism. The uptake and transport of DMY were time and concentration dependent. Interestingly, pH affected DMY uptake but not its bidirectional transport. MRP2 and BCRP were involved in the uptake and transport of DMY, which hindered the absorption of DMY in the intestinal. Thus, the present study may provide useful information for designing DMY delivery systems and avoiding DMY-drug interactions.

Density and morphology of crab burrows were compared using resin casts between exotic Spartina alterniflora marsh (SPA) and four mangrove habitats (Avicennia marina forest, AM; Kandelia obovata forest, KO; Aegiceras corniculatum forest, AC; Mudflat, MF) at a subtropical mangrove estuary, Yunxiao, China. Five burrow-morphological parameters (density, opening diameter, depth, branching and total burrow volume per m2) were measured. The results showed that there were significant differences in the morphology (depth and volume) of crab burrows between SPA and mangrove habitats. The depth (ANOVA, d.f. = 27, F = 24.212, P = 0.000) and total burrow volume (ANOVA, d.f. = 23, F = 3.666, P = 0.022) per m2 in SPA were significantly lower than those in the other four mangrove habitats. Correlation analysis indicated significant negative correlation between burrow depth and root density. We concluded that over-dense roots and subterranean stems of Spartina alterniflora impeded crabs excavating burrows extensively, both in the vertical and horizontal directions. Consequently, the invasion of Spartina alterniflora weakened the ecosystem engineering effects of mangrove crabs. The burrows in KO and AM had significantly higher burrow complexity than those in the other three habitats. We speculated that mangrove root was the main environmental variable resulting in the varied complexity of crab burrows. Higher root density or lower root density both impede crabs constructing complex burrows, while intermediate root density contributes to the development of higher borrow complexity.

We investigated the effects of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), alone and in combination, on apoptosis and intracellular calcium concentration in hepatocellular carcinoma (HepG2) cells. We used HepG2 cells to test the effects of ATRA and ATO, individually and in combination, on cell proliferation, apoptosis, and intracellular-free calcium concentration. The results indicate that each drug decreased cell proliferation, increased apoptosis, and increased intracellular-free calcium in a time- and dose-dependent manner. We also calculated the coefficients of drug interaction for sub-threshold administration of both drugs in combination (1 μmol/L each). ATRA and ATO acted synergistically in inhibition of cell proliferation and additively in the promotion of apoptosis. All-trans retinoic acid and ATO interacted synergistically to reduce cell proliferation in HepG2 cells.

By studying the handover process in HetNet network scenario with macrocell and picocell, analyzing and simulating the probabilities of successful handover in theory and geometry, respectively.

The traceability management system of aquatic product is based on RFID techniques which could obtain the function of aquatic products statistics and water quality monitoring automatically. The system frame, hardware and software design of micro-controller and anti-collision algorithm are issued in this paper. The identifying of aquatic product and water quality monitoring information are delivered to the management system and the speed of reading operation is increased greatly.

Based on the principle of orthogonal test, the optimization model of sunflower shaped arch bridge scheme was set up. The five key design parameters were selected as the main factors. The four computation index, which reflect mechanical performance, were selected as analytical objects. The 16 orthogonal experiment schemes were arranged with four levels orthogonal table . The curves of the factors to the index were obtained from the mechanical response under dead load and live load through the finite element analysis model. By the range analysis method, the influential levels of the factors to the index were obtained from the result of the test , and the factor optimizatuion level of the factors was determined to further optimize the layout scheme of the sunfloawer shaped arch bridge.

With the advances in clean energy, natural gas (methane) takes a greater proportion in total energy consumption. Methane gas detection technology has become an important research direction for fire alarm area. Using near-infrared absorption spectroscopy method, this gas detection technology has many unique advantages, such as intrinsic safe, good stability, good selectivity, long working life, etc. In this paper, a gas detection system based on wavelength modulation and second harmonic (2f) signal detection technology is proposed; the process of the first and second harmonic demodulation is simulated; the feasibility of using first harmonic as light intensity reference and the linear relationship between the concentration and second harmonic is analyzed. Finally, a theoretical guidance for product developing with above technology is provided as well.

Thermally evaporated molybdenum trioxide (MoO3) doped C60 films, which could change n type features of pristine C60 to form a p type mixed C60 layer, are investigated by x-ray and ultraviolet photoelectron spectroscopy. It is found that C60 HOMO progressively shifts closer to the Fermi level after increased MoO3 doping concentration, and final onset of C60 HOMO is pinned at binding energy of 0.20 eV, indicating the formation of p type C60 films. It is proposed that in charge transfer induced p type C60 formation, due to large electron affinity of MoO3 (6.37 eV), electrons from HOMO of C60 could easily transfer to MoO3 to form cations and therefore increase hole concentration, which could gradually push C60 HOMO to the Fermi level and finally form p type C60 films. Moreover, clear different types of C60 species have been confirmed from UPS spectra in highly doped films.

To investigate the epidemiological characteristics, clinical manifestations, diagnosis, and treatment of Brucella orchitis, so as to provide reliable evidence for the prevention and treatment of the disease.We conducted retrospective statistical analyses on the medical records of 48 outpatients and 21 inpatients with Brucella orchitis.Brucella orchitis was diagnosed in 6.67% of the male patients with brucellosis (69/1 034). The disease exhibited typical epidemiological features, with a higher incidence rate among those in frequent contact with sheep and elderly people, in the period from April to July, and in the areas with sheep husbandry. All the Brucella orchitis patients had such local symptoms as testicular pain and swelling, more frequently involving both testes, and other most common symptoms included fever, chills, sweating, and painful joints. Based on IIEF-5, 45 of the patients suffered from severe erectile dysfunction, with their reproductive function temporarily affected in the course of the disease. Misdiagnosis easily occurred in the early stage of the disease. Therapeutic options mainly included doxycycline hydrochloride and rifampicin, administered orally or intravenously, which could effect a cure, though relapse might occur in some cases.Bru- cella orchitis has distinct epidemiological characteristics, with clinical manifestations of testicular pain and swelling. Though a transient disease, it affects the reproductive function of the patient before cured. It can be treated by combined oral and intravenous medication, with painkillers or ice bags for testicular pain and swelling.

Removal of Cr(VI) from aqueous solution by strong alkaline anion exchange fiber (SAAEF) was achieved using batch adsorption experiments. The effect of contact time, initial Cr(VI) concentration and pH was investigated. The results showed that the maximum adsorption capacity of SAAEF was 187.7 mg/g at pH=1.0. The adsorption capacity increased with Cr(VI) concentration but decreased with pH value when pH>1.0. Adsorption isotherms at various temperatures were obtained. Langmuir, Freundlich, Dubinin-Radushkevich and Temkin models were adopted and the equilibrium data fitted best with the Langmuir isotherm. The constants of these models indicated that the adsorption process involved both chemisorption and physisorption. The values of thermodynamic parameters, including ΔH, ΔG and ΔS, suggested that the adsorption of Cr(VI) on SAAEF was a spontaneous, entropy-driven and endothermic process. Q(iso) was not a constant value, which indicated an inhomogenous energy distribution on SAAEF.

This paper using time time-procedure analysis method to analyze seismic response on a 80 m × 80 m bidirectional beam string structure model. Under vertical seismic action, we respectively compared to the seismic performance under the structure have or no supporting frame and have the same supporting frame but different support conditions. Under vertical seismic action, the axial force of brace is almost the same considering or unconsidering the supporting frame, while the upper beam vertical displacement is increased and the surrounding of the roof even increased several times considering supporting frame; the boundary conditions for the sliding hinge support bidirectional beam string structure which under vertical seismic ( middle seismic ) action the brace axial force and winding beam vertical displacement are nearly same with the fixed hinged support, while the horizontal displacement of the winding beam is larger than the fixed hinged support; the change of support conditions affect the order of the various modes of the structure but no affect the structural vibration modes.

For the improved three-level (TL) buck direct current-direct current (DC-DC) switching converter which is a high-order, discrete, non-linear, and time-variant dynamic system, the work multi-modalities and principle are analyzed, and the state space equation model is established by introducing the switch cycle averaging operator under low-frequency, small ripple, and small-signal assumption. The transfer function from control to output that is needed by closed-loop feedback system is deduced by introducing small-signal perturbation. The closed-loop control system is designed based on the transfer function model by applying feedback control theory. The experiment results show that closed-loop system has good dynamic and static performance, and further indicates that the mathematic models are reasonable.

The long time-delay often exists in industrial process. In order to overcome the big overshoot and long regulating time of the long time-delay system control, a new fuzzy self-adaptive PI-Smith control method is proposed. This method combines the Smith predictive control with fuzzy self-adaptive proportional-integral (PI) control. The traditional proportional-integral-derivative (PID) controller in Smith predictive control is replaced by fuzzy PI controller which utilizes the principle of fuzzy control to tune parameters of PI controller on-line. The results of simulation for electric furnace show that the method has the advantages of shortening regulating time, no overshoot, no steady-state error, excellent control accuracy, and good adaptive ability to the change of system model.

Objective To investigate the inhibitory effect of rosiglitazone(RSG) on fibroblast conditioned growth medium(FCGM)-induced myocardial hypertrophy and its mechanism in rats.Methods FCGM-stimulated protein synthesis and protein kinase C(PKC) activity were measured in neonatal rat ventricular cardiomyocytes in the absence or presence of RSG or the PKC inhibitor chelerythrine(che).Results Cultured neonatal rat ventricular fibroblast conditioned growth medium significantly enhanced protein synthesis of cardiomyocytes.Meanwhile ET-1 was detected in FCGM using the enzyme-linked immunosorbent assay(ELISA).RSG and che counteracted the growth promoting effect of FCGM possibly via suppressing PKC activity.Conclusion FCGM-induced myocardial hypertrophy may be associated with ET-1.The inhibitory effects of RSG on myocardial hypertrophy may be mediated through ET-1 and PKC.

2-Alkylthiobenzofuro[3,2-d]pyrimidinones 5 and 6 were synthesized by S-alkylation of 2,3-dihydro-2-thioxobenzofuro[3,2-d]pyrimidin-4(1H)-ones 4, which were obtained via aza-Wittig reaction of iminophosphorane 2 with CS2 and further reaction of the product with various amines. Compounds 5 and 6 exhibited fungicidal activity. For example, compound 6a, which has a small N-substituted methyl group, showed the best inhibitive activity (91%) against Dothiorella gregaria at 50 mg/L. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

Heavy metal contamination of soils, derived from sewage irrigation, mining and inappropriate utilization of various agrochemicals and pesticides, and so on, has been of wide concern in the last several decades. The Shenyang Zhangshi Irrigation Area (SZIA) in China is a representative area of heavy metal contamination of soils resulting from sewage irrigation for about 30 years. This study investigated the spatial distribution and temporal variation of soil cadmium (Cd) and copper (Cu) contamination in the SZIA. The soil samples were collected from the SZIA in 1990 and 2004; Cd and Cu in soils was analyzed and then the spatial distribution and temporal variation of Cd and Cu in soils were modeled using Kriging methods. The results show that long-term sewage irrigation had caused serious Cd and Cu contamination in soils. The mean and the maximum of soil Cd are markedly higher than the levels in second grade standard soil (LSGSS) in China, and the maximum of soil Cu is close to the LSGSS in China in 2004 and is more than the LSGSS in China in 1990. The contamination magnitude of soil Cd and the soil extent of Cd contamination had evidently increased since sewage irrigation ceased in 1992. The contamination magnitude of soil Cu and the soil extent of Cu contamination had evidently increased in topsoil, but obviously decresed in subsoil. The soil contamination of Cd and Cu was mainly related to Cd and Cu reactivation of contaminated sediments in Shenyang Xi River and the import of Cd and Cu during irrigation. The eluviation of Cd and Cu in contaminated topsoil with rainfall and irrigation water was another factor of temporal-spatial variability of Cd and Cu contamination in soils.