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A three-component reductive cross-coupling of aryl halides, aldehydes, and alkenes by nickel/photoredox dual catalysis is reported. The key to success for this tandem transformation is to identify α-silylamine as a unique organic reductant.

Gasoline is a globally used primary fuel. The submicron particles at gasoline stations have not been extensively investigated. This study aimed to evaluate the exposure concentrations and inhalation risk of submicron particles at a gasoline station. Temporal variations in particle concentrations and size distributions were measured using a real-time system. The effective doses of submicron particles deposited in different organs were analyzed using a computational fluid dynamics model and the value of environmental monitoring (including the size distributions of particles by number). The number concentration (NC) was higher during working hours than that of the background. Submicron particles gathered predominantly at 30.5 nm and 89.8 nm during working time. The effective doses of submicron particles deposited in the olfactory system and lungs were 0.131 × 10−3 and 0.014 mg, respectively, of which 0.026 × 10−3 mg potentially reached the brain. In a female worker with 3 years of exposure, the average daily effective doses in the olfactory system, lungs, and brain were 2.19 × 10−7 mg/kg·d−1, 2.34 × 10−5 mg/kg·d−1, and 4.35 × 10−8 mg/kg·d−1, respectively. These findings indicated that workers at this gasoline station had a high inhalation risk of submicron particles. This study provides baseline data on submicron particles at gasoline stations and a critical basis for investigating disease risk in longitudinal epidemiological studies.

An electron donor-acceptor complex-enabled, nickel-catalyzed three-component net-reductive 1,2-alkylacylation of alkenes is developed. This conjunctive reductive acyl cross-coupling process obviates the use of an exogenous photocatalyst and a stoichiometric metal-based reductant, affording various synthetically useful 1,3-dicarbonyl compounds in good yields with a broad substrate scope and excellent functional group tolerance. Both alkyl and acyl electrophiles are derived from the highly abundant and readily accessible carboxylic acids, making the catalytic 1,2-dicarbofunctionalization more synthetically general and sustainable.

Innate immunity is central to controlling pathogenic infections and maintaining the homeostasis of the host. In this study, we have revealed a novel mechanism regulating innate immune responses during viral and bacterial infections.

The choroid plexus (ChP) is the source of cerebrospinal fluid (CSF). The ChP-CSF system not only provides necessary cushion for brain but also works as a sink for waste clearance. During sepsis, pathogens and host immune cells can weaken ChP barrier and enter the brain, causing cerebral dysfunctions known as sepsis-associated encephalophagy. Here, we used human ChP organoid to model herpes simplex virus type 1(HSV-1) infection and found ChP epithelial cells were highly susceptible to HSV-1. Since the current ChP organoid model lacks a functional innate immune component, particularly microglia, we next developed a new microglia-containing ChPO (M-ChPO) model, and found microglia could effectively limit HSV-1 infection and protect epithelial barrier in ChP organoids. Furthermore, we found the innate immune cGAS-STING pathway and its downstream interferon response were essential, as cGAS inhibitor RU.512 or STING inhibitor H-151 abolished microglia antiviral function and worsened ChP barrier in organoids. These results together indicated that cGAS-STING pathway coordinates antiviral response in ChP and contributes to treating sepsis or related neurological conditions. This article is protected by copyright. All rights reserved.

Selective alkene dialkylation represents one of the most challenging transformations in alkene difunctionalization reactions. Here, we report an excellent site-selective dialkylation of alkenes via photoredox/nickel dual catalysis. Taking advantage of the synergistic catalytic model, excellent orthogonal substrate activation could be achieved to address otherwise difficult-to-controlled chemo- and regioselectivity issues. Alkyl halides and alkyl tertiary amines are used as mild alkylating reagents, thus bypassing the use of sensitive organometallic reagents. The present strategy shows a broad scope for both alkyl electrophiles and nucleophiles, and provides a facile access to valuable β-amino acid derivatives, which are key structural units among numerous biologically active compounds.

Sterically hindered α-tertiary dialkyl ketones are difficult to synthesize via traditional organometallic approaches. Recently developed reductive acyl-coupling strategy provides an access to α-tertiary dialkyl ketones with using either tertiary acyl electrophiles or tertiary alkyl radical precursors. However, due to the large steric hindrance effect, tertiary acyl donors or alkyl donors are largely restricted to highly strained ring system, thus limited the broad substrate scope of more general tertiary alkyl carboxylic acid derivatives. Herein, we develop a photoinduced nickel-catalyzed reductive acyl-coupling reaction with two different carboxylic acid esters to synthesize steric bulky dialkyl ketones in the absence of exogenous photocatalyst or stoichiometric metal reductant. Various unstrained tertiary acyl electrophiles can couple with 1o, 2o, 3o alkyl radical to afford all carbon quaternary aliphatic ketones including α-tertiary amino ketones with satisfactory yields under mild conditions, which have been previously difficult to access or not yet to be explored in literature.

Based on the deformation and damage characteristics of the surrounding rock in a large-section gob-side entry retaining and combined with field observations and an analysis of the dominant factors, an overall deformation control plan is formulated. The plan mainly includes a structure of high strength, high stiffness and high ductility for roadside support; the reinforcement of the roadway-in support; and the setup entry hydraulic fracturing pressure release mechanism and advanced long, horizontal borehole “fracturing-jet” pressure relief technology. Industrial field tests were completed taking Tangan coal mine as the engineering background. The research shows that the large-section gob-side entry retaining has the typical “asymmetric” overall deformation and damage characteristics, including top coal sinking along the inner side of the roadside support, the whole roadside support structure skewing, and even splitting damage; floor heaving; and the coal-side bolt support structure basically losing support ability and bulging out from the coal side. The dominant factors of deformation damage are disintegration of the floor mudstone by water and deflection deformation under horizontal stress, splitting damage in the concrete roadside support under asymmetric load, damage and expansion due to the insufficient strength of the coal side support, strong dynamic pressure on the roof, and the mutual influence of support and pressure relief. The industrial test shows that the deformation control scheme optimizes the stress environment of the gob-side entry retaining space, the deformation control effect is remarkable, and the roadside fully meets the reuse requirements.

Mitogen-activated protein kinases (MAPKs) play critical roles in the induction of numerous cytokines, chemokines, and inflammatory mediators that mobilize the immune system to counter pathogenic infections. Dual-specificity phosphatase-1 (DUSP1) is a member of dual-specificity phosphatases, which inactivates MAPKs through a negative feedback mechanism. Here we report that in response to viral and bacterial infections, not only DUSP1 transcript but also itsN6-methyladenosine (m6A) level rapidly increase together with the m6A reader protein YTHDF2, resulting in enhanced YTHDF2-mediated DUSP1 transcript degradation. Knockdown of DUSP1 promotes p38 and JNK phosphorylation and activation, thus increasing the expression of innate immune response genes including IL1β, CSF3, TGM2 and SRC. Similarly, knockdown of m6A eraser ALKBH5 increases DUSP1 transcript m6A level resulting in accelerated transcript degradation, activation of p38 and JNK, and enhanced expression of IL1β, CSF3, TGM2 and SRC. These results demonstrate that m6A and reader protein YTHDF2 orchestrate optimal innate immune response during viral and bacterial infections by downregulating the expression of a negative regulator DUSP1 of the p38 and JNK pathways that are central to innate immune response against pathogenic infections.IMPORTANCEInnate immunity is central for controlling pathogenic infections and maintaining the homeostasis of the host. In this study, we have revealed a novel mechanism regulating innate immune response during viral and bacterial infections. We have found thatN6-methyladenosine (m6A) and the reader protein YTHDF2 regulate dual-specificity phosphatase-1, a negative regulator of mitogen-activated protein kinases p38 and JNK, to maximize innate immune response during viral and bacterial infections. These results provide novel insights into the mechanism regulating innate immunity, which could help the development of novel approaches for controlling pathogenic infections.

Background: Powder-coating processes have been extensively used in various industries. The submicron particles generated during the powder-coating process in the workplace have complex compositions and can cause serious diseases. The purpose of this study was to better understand the health risks and respiratory intake of submicron particles during the powder coating process.Methods: The concentrations of and variations in submicron particles were measured using real-time instruments. The health risks of submicron particles were analyzed using the Stoffenmanager Nano model. A new computational fluid dynamics model was used to assess the respiratory intake of ultrafine particles (UFPs), which was indicated by the deposited dosage of UFPs in the olfactory area, nasal cavity, and lungs. The deposited doses of UFPs were used to calculate the average daily doses (ADDs) of workers, according to the method described by the Environmental Protection Agency.Results: The number concentration (NC), mass concentration, surface area concentration, personal NC, and lung-deposited surface area concentration of submicron particles were >105 pt/cm3, 0.2–0.4 mg/m3, 600–1,200 μm2/cm3, 0.7–1.4 pt/cm3, and 100–700 μm2/cm3, respectively. The size distribution showed that the submicron particles mainly gathered between 30 and 200 nm. The health risk of submicron particles was high. Upon respiratory intake, most UFPs (111.5 mg) were inhaled into the lungs, a few UFPs (0.272 mg) were trapped in the nasal cavity, and a small minority of UFPs (0.292 mg) were deposited in the olfactory area. The ADD of male workers with 10 years of exposure in the olfactory area, nasal cavity, and lung were 1.192 × 10–3 mg/kg·d−1, 1.11 × 10–3 mg/kg·d−1, and 0.455 mg/kg·d−1, respectively.Conclusion: Owing to the high concentrations of submicron particles, the workers involved in the powder-coating process are at a high health risk. Moreover, the respiratory intake of UFPs by workers is high, which is suggested by the highly deposited dosage of UFPs in the lungs and the corresponding high ADD in workers. Control measures, including engineering control, management control, and personal protective equipment, must be improved for the protection of workers.

A mild and site-selective hydroaminoalkylation of activated and unactivated alkenes via dual photoredox/Ni catalysis is developed. This dual catalytic strategy enables exclusive access to α-selective products, which is complementary to previously reported photocatalytic hydroaminoalkylation of activated alkenes that provides the β-selective products. The chain-walking of a Ni-H intermediate toward a carbonyl allows for the hydroaminoalkylation of unactivated alkenes at remote

This study focuses on the geology, geochemistry, Sr-Nd isotopes and their tectonic settings of three types of basalts in Diyanmiao ophiolite in the Xar Moron area located on the eastern margin of the Central Asian Orogenic Belt. Type I basalts are oceanic tholeiites with a depleted light rare earth element (LREE) pattern, which are similar to the typical N-mid-oceanic ridge basalt (MORB) and suggests that they were formed at a mid-oceanic ridge. The initial 87Sr/86Sr ratios of Type I basalts range from 0.703 966 to 0.705 276 and the eNd(t) values are from 16.49 to 17.15, indicating that they were derived from a depleted mantle source. Type II basalts belong to the medium-potassium calc-akaline series and have the geochemical characteristics of Nb-enriched basalt (NEB) with high Nb content (14.5 ppm) and strong enrichment in LREEs, implying that they were created by the partial melting of mantle wedge peridotite that previously metasomatized by slab melts. Type III basalts are high-Al basalt (HAB) with high-Al contents (Al2O3=16.75 wt.%–18.00 wt.%), distinct Nb depletion and high Th/Yb ratios. Thus they were likely generated in a normal island-arc setting. Therefore, the association of MORB, NEB, and HAB in the study area may be due to the subduction of a mid-oceanic ridge, and the Diyanmiao ophiolite is proposed to be formed in the forearc setting of a mid-oceanic ridge subduction system.

Transition-metal-catalyzed carbon–carbon cross-coupling reactions represent a significant achievement in modern synthetic chemistry and they have become indispensable tools for the construction of organic molecules. Despite the important progress in this area, methods for coupling two C(sp3)-hybridized alkyl fragments remain elusive. To date, existing methods have largely relied on using organometallic reagents as the nucleophilic coupling partners, thereby inevitably limiting the compatibility of functional groups. Although cross-electrophile coupling may alleviate the pain somewhat, it is necessary to add a stoichiometric amount of a reductant to complete the catalytic cycle. Recently, the emergence of photoredox-mediated single-electron transmetalation has evoked an ideal paradigm for selectively manipulating C(sp3)–C(sp3) cross-coupling with the unprecedented application of native C(sp3) functionalities instead of organometallic reagents, thus opening a new window for C(sp3)–C(sp3) bond creation. This short review highlights the recent advances in this exciting subfield.1 Introduction2 Nickel/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling3 Palladium/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling4 Copper/Photoredox-Catalyzed C(sp3)–C(sp3) Cross-Coupling5 Direct C(sp3)–H Alkylation via Metallaphotoredox-Mediated Hydrogen­ Atom Transfer6 Conclusion and Perspectives

Patient-derived hiPSCs could generate indefinitely illness-related cells and organoids, allowing research scientist to reproduce some pathologic change of human sickness models in petri dishes. Whereas, dermal fibroblasts require some traumatic injury to obtain and have the risky of accumulating variations due to unveil to external stimulus such as UV light. Meanwhile, peripheral blood is regarded to be a more excellent source of somatopiasm because it is less damage to collect and its mutation load is significantly lower than that of skin tissue.In this paper, we describe the successful construction of non-integration hiPSCs form human peripheral blood cells by Sendai virus. A healthy adult female of Han nationality from China contributed her peripheral blood mononuclear cells (PBMCs). Non-integrating Sendai virus recombinant PBMCs with human OSKM (Oct4, Sox2, Kl4 and c-Myc) transcription factors.The pluripotency of transgenic-free iPSCs was confirmed by immunofluorescence staining of pluripotency markers and the capacity of iPSCs to initially differentiate into 3 germ layers in vitro. Moreover, iPSC lines demonstrated awfully normal karyotypes. In the research of illness progression and pathogenesis (eg, DMD, SMA, ALS), iPSC lines can be used as controls.

BackgroundDue to the rapid development of the powder-coating process and growing awareness of occupational health, the ultrafine particles (UFPs) generated during the powder-coating process have become a serious and urgent problem. However, researchers have not clearly understood the risk of exposure to the UFPs and inhalation risk of the UFPs. ResultsIrregularly shaped, aggregating particles containing Si, Al, Fe, Mg, Pt, and Ca elements were sampled from the work area. The number concentration (NC), mass concentration, surface concentration, personal NC, and lung-deposited surface area concentration of the particles were high: >105 pt/cm3, 0.2–0.4 mg/cm3, 600–1200 μm2/cm3, 0.7–1.4 pt/cm3, and 100–700 μm2/cm3, respectively. In the particle number count, majority of the particles were 30–200 nm in size. The time-weighted and task-weighted levels of exposure to the particles were high. Upon inhalation, most (71.09 mg) of the particles ranging from 10.4 nm to 96.8 nm accumulated in olfactory area, and a few of the particles (0.649 mg) was taken into lung. Similarly, the majority (1195 mg) of the particles that ranged in size from 100.3 nm to 469.8 nm were deposited on the lungs, and the remaining of the particles were trapped in the nasal cavity.ConclusionsDue to the high emissions rate of the UFPs and insufficient control measures, the workers involved in the powder-coating process are at high exposure risk. Moreover, the risk of inhalation of the UFPs by the workers is high, which is suggested by the high quantities of the UFPs deposited in the lungs and on the olfactory. To protect the workers, the series of measures we proposed, including engineering control, management control, and personal protection equipment should be implemented.

A highly chemo- and regioselective intermolecular 1,2-aryl-aminoalkylation of alkenes by photoredox/nickel dual catalysis is described here. This three-component conjunctive cross-coupling is highlighted by its first application of primary alkyl radicals, which were not compatible in previous reports. The readily prepared α-silyl amines could be transferred to α-amino radicals by photo-induced single electron transfer step. The radical addition/cross-coupling cascade reaction proceeds under mild, base-free and redox-neutral conditions with good functional group tolerance, and importantly, provides an efficient and concise method for the synthesis of structurally valuable α-aryl substituted γ-amino acid derivatives motifs.

Reconfigurable photonic devices are important constituents for future optical integrated circuits, where electro-optic manipulation of the light field in a lithium niobate (LN) waveguide is one of the promising solutions. Herein, we demonstrate a paradigm shift of the beam steering mechanism where reconfigurable beam steering is enabled by the wavefront shaping technology. Furthermore, this strategy is fully compatible with the electro-optic tuning mechanism of the LN multimode waveguide, where microstructured serrated array electrodes are employed to fine tune the output beam upon its reconfigurable output position. Our results provide new, to the best of our knowledge, insight for molding the flow of light in multimode waveguides and shed new light on beam steering photonic devices.

A method was developed for ketone synthesis via a photoredox-assisted reductive acyl cross-coupling (PARAC) using a nickel/photoredox dual-catalyzed cross-electrophile coupling of two different carboxylic acid esters. A variety of aryl, 1°, 2°, 3°-alkyl 2-pyridyl esters can act as acyl electrophiles while N-(acyloxy)phthalimides (NHPI esters) act as 1°, 2°, 3°-radical precursors. Our PARAC strategy provides an alternative and reliable way to synthesize various sterically congested 3°-3°, 3°-2°, and aryl-3° ketones under mild and highly unified conditions, which have been otherwise difficult to access. The combined experimental and computational studies identified a Ni0 /NiI /NiIII pathway for ketone formation.

Newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global pandemic with astonishing mortality and morbidity. The high replication and transmission of SARS-CoV-2 are remarkably distinct from those of previous closely related coronaviruses, and the underlying molecular mechanisms remain unclear. The innate immune defense is a physical barrier that restricts viral replication. We report here that the SARS-CoV-2 Nsp5 main protease targets RIG-I and mitochondrial antiviral signaling (MAVS) protein via two distinct mechanisms for inhibition. Specifically, Nsp5 cleaves off the 10 most-N-terminal amino acids from RIG-I and deprives it of the ability to activate MAVS, whereas Nsp5 promotes the ubiquitination and proteosome-mediated degradation of MAVS. As such, Nsp5 potently inhibits interferon (IFN) induction by double-stranded RNA (dsRNA) in an enzyme-dependent manner. A synthetic small-molecule inhibitor blunts the Nsp5-mediated destruction of cellular RIG-I and MAVS and processing of SARS-CoV-2 nonstructural proteins, thus restoring the innate immune response and impeding SARS-CoV-2 replication. This work offers new insight into the immune evasion strategy of SARS-CoV-2 and provides a potential antiviral agent to treat CoV disease 2019 (COVID-19) patients. IMPORTANCE The ongoing COVID-19 pandemic is caused by SARS-CoV-2, which is rapidly evolving with better transmissibility. Understanding the molecular basis of the SARS-CoV-2 interaction with host cells is of paramount significance, and development of antiviral agents provides new avenues to prevent and treat COVID-19 diseases. This study describes a molecular characterization of innate immune evasion mediated by the SARS-CoV-2 Nsp5 main protease and subsequent development of a small-molecule inhibitor.

An efficient electrophilic N-cyanation of amines with a stable and less-toxic cyanobenziodoxole reagent towards the synthesis of cyanamides is disclosed. This synthetically practicable strategy allows the construction of a wide variety of cyanamides under very mild and simple conditions with a broad functional group compatibility, and showcases a huge potential in late-stage modification of complex molecules.

Objectives This study aimed to clarify the exposure characteristics and risks of ultrafine particles from the blast furnace process and to provide a reasonable control strategy for protecting the health of workers. Methods The blast furnace location of a steelmaking plant was selected as a typical investigation site. A membrane‐based sampling system was used to collect ultrafine particles to analyze their morphology and elemental compositions. A real‐time system was used to monitor the total number concentration (NC), total respirable mass concentration (MC), surface area concentration (SAC), and size distribution by number. The risk level of ultrafine particles was analyzed using the Stoffenmanager‐Nano model. Results The total NC, total MC, and SAC increased significantly relative to background concentrations after slag releasing started and decreased gradually after the activity stopped. The three highest total concentrations during slag releasing were 3‐10 times higher than those of the background or non‐activity period. The ultrafine particles were mainly gathered at 10.4 or 40 nm, and presented as lump‐like agglomerates. The metal elements (Al and Pt) in the ultrafine particles originated from slag and iron ore. The risk level of the ultrafine particles was high, indicating the existing control measures were insufficient. Conclusions The blast furnace workers are at high risk due to exposure to high levels of ultrafine particles associated with working activity and with a bimodal size distribution. The existing control strategies, including engineering control, management control, and personal protection equipment need to be improved.

Autophagy maintains homeostasis and is induced upon stress. Yet, its mechanistic interaction with oncogenic signaling remains elusive. Here, we show that in BRAFV600E-melanoma, autophagy is induced by BRAF inhibitor (BRAFi), as part of a transcriptional program coordinating lysosome biogenesis/function, mediated by the TFEB transcription factor. TFEB is phosphorylated and thus inactivated by BRAFV600E via its downstream ERK independently of mTORC1. BRAFi disrupts TFEB phosphorylation, allowing its nuclear translocation, which is synergized by increased phosphorylation/inactivation of the ZKSCAN3 transcriptional repressor by JNK2/p38-MAPK. Blockade of BRAFi-induced transcriptional activation of autophagy-lysosomal function in melanoma xenografts causes enhanced tumor progression, EMT-transdifferentiation, metastatic dissemination, and chemoresistance, which is associated with elevated TGF-β levels and enhanced TGF-β signaling. Inhibition of TGF-β signaling restores tumor differentiation and drug responsiveness in melanoma cells. Thus, the “BRAF-TFEB-autophagy-lysosome” axis represents an intrinsic regulatory pathway in BRAF-mutant melanoma, coupling BRAF signaling with TGF-β signaling to drive tumor progression and chemoresistance., The relationship between autophagy and BRAF signalling is unclear. Here, the authors describe that BRAF inhibition induces the autophagy-lysosomal function in BRAF-mutant melanomas via modulation of the TFEB and ZKSCAN3 transcriptome, which downregulates TGF-β and suppresses melanoma progression.

Objectives To provide a guideline for assessing the occupational exposure to nanomaterials in workplaces in China. Methods Based on the basic requirement for the sampling of harmful substances, condensation particle counter/optical particle counter (CPC/OPC) was selected as the tool and the total number concentration (TNC) was used as an index to measure engineering nanomaterials in workplaces. Results The strategy included instrument preparation, identification of particle‐emission source, particle‐property analysis, measurement of background concentration, concentration measurement based on working activity, concentration calculation and analysis, and recording of measurements. Conclusions The draft guideline based on traditional industrial hygiene practices can be used to identify the emission source of nanomaterials, qualitatively and quantitatively assess exposure to nanomaterials in workplaces.

A straightforward gram-scale preparation of cyclohexa-1,4-diene-based hydrogen cyanide (HCN) surrogates is reported. These are bench-stable but formally release HCN and rearomatize when treated with Lewis acids. For BCl3 , the formation of the isocyanide adduct [(CN)BCl3 ]- and the corresponding Wheland complex was verified by mass spectrometry. In the presence of 1,1-di- and trisubstituted alkenes, transfer of HCN from the surrogate to the C-C double bond occurs, affording highly substituted nitriles with Markovnikov selectivity. The success of this transfer hydrocyanation depends on the Lewis acid employed; catalytic amounts of BCl3 and (C6 F5 )2 BCl are shown to be effective while B(C6 F5 )3 and BF3 ⋅OEt2 are not.

A number of control banding (CB) tools have been developed specifically for managing the risk of exposure to engineered nanomaterials. However, data on the methodological differences between common CB tools for nanomaterials in workplaces are rare. A comparative study with different CB tools, such as Nanosafer, Stoffenmanager-Nano, Nanotool, Precautionary Matrix, ECguidance, IVAM Guidance, ISO, and ANSES, was performed to investigate their qualitative and quantitative differences in real exposure scenarios. These tools were developed for different purposes, with different application domains, methodological principles, and criteria. Multi-criteria analysis showed that there was a diverse distribution of these eight CB tools across different evaluation indicators. The total evaluation scores for Nanotool, Stoffenmanager-Nano, and Nanosafer were higher than the other tools. Quantitative comparisons demonstrated that ANSES, ECguidance, and IVAM Guidance tools were better in terms of information availability. Nanotool, Stoffenmanager-Nano, and ECguidance were better in terms of the sensitivity of outputs to changes in exposure parameters. The Nanotool, ANSES, and ECguidance tools were better in terms of accuracy of hazard outcomes evaluated with toxicological data. The Stoffenmanager-Nano, Nanotool, and Nanosafer tools' exposure scores for seven scenarios had a good correlation with measurement data. The Nanotool and Stoffenmanager-Nano tools had much higher comprehensive advantages based on quantitative and qualitative assessment. More comparative studies evaluating different tools are required, using more types of nanomaterials in real exposure scenarios.

Multimode fibers provide a unique opportunity for exploring the spatial degrees of freedom for high throughput light transmission. However, the modal dispersion prevents from the straightforward application of multimode fibers for space division multiplexing, such as image transmission. Herein, we propose and experimentally demonstrate a deep neural network termed multimode fiber inverse-scattering net for overcoming the modal dispersion induced scrambling in multimode fibers. Such a network is capable of transmitting grayscale image through the multimode fiber with high fidelity. 256-level grayscale images with 128 × 128 spatial channels encoded in the input wavefront can be retrieved from the output optical speckle patterns, where the average Pearson correlation coefficient and structural similarity index are as large as 0.97 and 0.95, respectively. Our results demonstrate that the proposed deep neural network has an excellent ability for learning the relationship between the input and output optical fields of a multimode fiber, which might facilitate the realization of high throughput space division multiplexing through multimode fibers.