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Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance
- Source :
- Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Portfolio, 2019.
-
Abstract
- The relationship between autophagy and BRAF signalling is unclear. Here, the authors describe that BRAF inhibition induces the autophagy-lysosomal function in BRAF-mutant melanomas via modulation of the TFEB and ZKSCAN3 transcriptome, which downregulates TGF-β and suppresses melanoma progression.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.16402280b75e478390036fae4511579a
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-019-09634-8