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2. Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials

Author

Zayat, Ahmed, Machado, Ana Rita, Cuervo, Andrea, Mahto, Arti, Cubuk, Cankut, Rawlings, Charlotte, Mosanya, Chijioke, Buckley, Chris, Holroyd, Chris, Maskall, Debbie, Carlucci, Francesco, Thorborn, Georgina, Tan, Gina, Lliso-Ribera, Gloria, Rizvi, Hasan, Peel, Joanna, Fonseca, João Eurico, Isaacs, John, Ramírez, Julio, Meric de Bellefon, Laurent, Fossati-Jimak, Liliane, Githinji, Mary, Congia, Mattia, Millar, Neal, Purkayastha, Nirupam, Celis, Raquel, Seth, Rakhi, Hands-Greenwood, Rebecca, Landewé, Robert, Perniola, Simone, Alivernini, Stefano, Marcia, Stefano, Marini, Stefano, Kelly, Stephen, Romão, Vasco, Rivellese, Felice, Nerviani, Alessandra, Giorli, Giovanni, Warren, Louise, Jaworska, Edyta, Bombardieri, Michele, Lewis, Myles J, Humby, Frances, Pratt, Arthur G, Filer, Andrew, Gendi, Nagui, Cauli, Alberto, Choy, Ernest, McInnes, Iain, Durez, Patrick, Edwards, Christopher J, Buch, Maya H, Gremese, Elisa, Taylor, Peter C, Ng, Nora, Cañete, Juan D, Raizada, Sabrina, McKay, Neil D, Jadon, Deepak, Sainaghi, Pier Paolo, Stratton, Richard, Ehrenstein, Michael R, Ho, Pauline, Pereira, Joaquim P, Dasgupta, Bhaskar, Gorman, Claire, Galloway, James, Chinoy, Hector, van der Heijde, Désirée, Sasieni, Peter, Barton, Anne, and Pitzalis, Costantino

Published
2023
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3. Reducing Antibiotic Prescribing in Primary Care for Respiratory Illness.

Author

Kronman, Matthew P, Gerber, Jeffrey S, Grundmeier, Robert W, Zhou, Chuan, Robinson, Jeffrey D, Heritage, John, Stout, James, Burges, Dennis, Hedrick, Benjamin, Warren, Louise, Shalowitz, Madeleine, Shone, Laura P, Steffes, Jennifer, Wright, Margaret, Fiks, Alexander G, and Mangione-Smith, Rita

Subjects
Humans, Streptococcal Infections, Respiratory Tract Infections, Pharyngitis, Bronchitis, Sinusitis, Otitis Media, Acute Disease, Anti-Bacterial Agents, Confidence Intervals, Logistic Models, Odds Ratio, Communication, Pediatric Nursing, Education, Distance, Child, Child, Preschool, Infant, Outpatients, Program Development, Primary Health Care, Chicago, Female, Male, Intention to Treat Analysis, Inappropriate Prescribing, Quality Improvement, Pediatricians, Pediatrics, Medical and Health Sciences, Psychology and Cognitive Sciences
Abstract

BackgroundOne-third of outpatient antibiotic prescriptions for pediatric acute respiratory tract infections (ARTIs) are inappropriate. We evaluated a distance learning program's effectiveness for reducing outpatient antibiotic prescribing for ARTI visits.MethodsIn this stepped-wedge clinical trial run from November 2015 to June 2018, we randomly assigned 19 pediatric practices belonging to the Pediatric Research in Office Settings Network or the NorthShore University HealthSystem to 4 wedges. Visits for acute otitis media, bronchitis, pharyngitis, sinusitis, and upper respiratory infection for children 6 months to

Published
2020

5. Stratification of biological therapies by pathobiology in biologic-naive patients with rheumatoid arthritis (STRAP and STRAP-EU): two parallel, open-label, biopsy-driven, randomised trials

Author

Rivellese, Felice, primary, Nerviani, Alessandra, additional, Giorli, Giovanni, additional, Warren, Louise, additional, Jaworska, Edyta, additional, Bombardieri, Michele, additional, Lewis, Myles J, additional, Humby, Frances, additional, Pratt, Arthur G, additional, Filer, Andrew, additional, Gendi, Nagui, additional, Cauli, Alberto, additional, Choy, Ernest, additional, McInnes, Iain, additional, Durez, Patrick, additional, Edwards, Christopher J, additional, Buch, Maya H, additional, Gremese, Elisa, additional, Taylor, Peter C, additional, Ng, Nora, additional, Cañete, Juan D, additional, Raizada, Sabrina, additional, McKay, Neil D, additional, Jadon, Deepak, additional, Sainaghi, Pier Paolo, additional, Stratton, Richard, additional, Ehrenstein, Michael R, additional, Ho, Pauline, additional, Pereira, Joaquim P, additional, Dasgupta, Bhaskar, additional, Gorman, Claire, additional, Galloway, James, additional, Chinoy, Hector, additional, van der Heijde, Désirée, additional, Sasieni, Peter, additional, Barton, Anne, additional, Pitzalis, Costantino, additional, Zayat, Ahmed, additional, Machado, Ana Rita, additional, Cuervo, Andrea, additional, Mahto, Arti, additional, Cubuk, Cankut, additional, Rawlings, Charlotte, additional, Mosanya, Chijioke, additional, Buckley, Chris, additional, Holroyd, Chris, additional, Maskall, Debbie, additional, Carlucci, Francesco, additional, Thorborn, Georgina, additional, Tan, Gina, additional, Lliso-Ribera, Gloria, additional, Rizvi, Hasan, additional, Peel, Joanna, additional, Fonseca, João Eurico, additional, Isaacs, John, additional, Ramírez, Julio, additional, Meric de Bellefon, Laurent, additional, Fossati-Jimak, Liliane, additional, Githinji, Mary, additional, Congia, Mattia, additional, Millar, Neal, additional, Purkayastha, Nirupam, additional, Celis, Raquel, additional, Seth, Rakhi, additional, Hands-Greenwood, Rebecca, additional, Landewé, Robert, additional, Perniola, Simone, additional, Alivernini, Stefano, additional, Marcia, Stefano, additional, Marini, Stefano, additional, Kelly, Stephen, additional, and Romão, Vasco, additional

Published
2023
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6. Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients: the R4-RA RCT

Author

Humby, Frances, primary, Durez, Patrick, additional, Buch, Maya H, additional, Lewis, Myles J, additional, Bombardieri, Michele, additional, John, Christopher, additional, Rizvi, Hasan, additional, Warren, Louise, additional, Peel, Joanna, additional, Fossati-Jimack, Liliane, additional, Hands, Rebecca E, additional, Giorli, Giovanni, additional, Rivellese, Felice, additional, Cañete, Juan D, additional, Taylor, Peter C, additional, Sasieni, Peter, additional, Fonseca, João E, additional, Choy, Ernest, additional, and Pitzalis, Costantino, additional

Published
2022
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8. First-In-Human Phase I Study of a Next-Generation, Oral, TGFβ Receptor 1 Inhibitor, LY3200882, in Patients with Advanced Cancer

Author

Yap, Timothy A., primary, Vieito, Maria, additional, Baldini, Capucine, additional, Sepúlveda-Sánchez, Juan Manuel, additional, Kondo, Shunsuke, additional, Simonelli, Matteo, additional, Cosman, Rasha, additional, van der Westhuizen, Andre, additional, Atkinson, Victoria, additional, Carpentier, Antoine F., additional, Löhr, Mario, additional, Redman, Rebecca, additional, Mason, Warren, additional, Cervantes, Andres, additional, Le Rhun, Emilie, additional, Ochsenreither, Sebastian, additional, Warren, Louise, additional, Zhao, Yumin, additional, Callies, Sophie, additional, Estrem, Shawn T., additional, Man, Michael, additional, Gandhi, Leena, additional, Avsar, Emin, additional, and Melisi, Davide, additional

Published
2021
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9. Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial

Author

Humby, Frances, primary, Durez, Patrick, additional, Buch, Maya H, additional, Lewis, Myles J, additional, Rizvi, Hasan, additional, Rivellese, Felice, additional, Nerviani, Alessandra, additional, Giorli, Giovanni, additional, Mahto, Arti, additional, Montecucco, Carlomaurizio, additional, Lauwerys, Bernard, additional, Ng, Nora, additional, Ho, Pauline, additional, Bombardieri, Michele, additional, Romão, Vasco C, additional, Verschueren, Patrick, additional, Kelly, Stephen, additional, Sainaghi, Pier Paolo, additional, Gendi, Nagui, additional, Dasgupta, Bhaskar, additional, Cauli, Alberto, additional, Reynolds, Piero, additional, Cañete, Juan D, additional, Moots, Robert, additional, Taylor, Peter C, additional, Edwards, Christopher J, additional, Isaacs, John, additional, Sasieni, Peter, additional, Choy, Ernest, additional, Pitzalis, Costantino, additional, Thompson, Charlotte, additional, Bugatti, Serena, additional, Bellan, Mattia, additional, Congia, Mattia, additional, Holroyd, Christopher, additional, Pratt, Arthur, additional, Cabral da Fonseca, João Eurico, additional, White, Laura, additional, Warren, Louise, additional, Peel, Joanna, additional, Hands, Rebecca, additional, Fossati-Jimack, Liliane, additional, Hadfield, Gaye, additional, Thorborn, Georgina, additional, Ramirez, Julio, additional, and Celis, Raquel, additional

Published
2021
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11. Dissimilatory iron(III) reduction by Rhodobacter capsulatus

Author

Dobbin, Paul S., Warren, Louise H., Cook, Nicola J., McEwan, Alastair G., Powell, Anne K., and Richardson, David J.

Subjects
Bacteria, Photosynthetic -- Research, Carotenoids -- Research, Biological sciences
Abstract

The photosynthetic proteobacterium Rhodobacter capsulatus can undergo dissimilatory Fe(III) reduction. Several Fe(III) complexes were able to act as substrates for intact cells and membrane fractions of strain N22DNAR utilizing a ferrozine assay for Fe(II) formation. Cytochrome bc1 complex's function can be observed only with the superior substrate. Periods of membrane potential generation were directly related to the amount of complex added and were extended in the presence of 2-heptyl-4-hydroxyquinoline-N-oxide.

Published
1996

23. A l'ecart (Short story).

Author

Warren, Louise

Subjects
A L'ecart (Short story), WARREN, Louise
Abstract

Presents the short story "A l'ecart," by Louise Warren.

Published
2003

24. The Lipoprotein-Associated Coagulation Inhibitor That Inhibits the Factor VII-Tissue Factor Complex Also Inhibits Factor Xa: Insight Into Its Possible Mechanism of Action

Author

Broze, George J., Warren, Louise A., Novotny, William F., Higuchi, Darryl A., Girard, James J., and Miletich, Joseph P.

Abstract

Blood coagulation is initiated when plasma factor Vll(a) binds to its essential cofactor tissue factor (TF) and proteo-lytically activates factors X and IX. Progressive inhibition of TF activity occurs upon its addition to plasma. This process is reversible and requires the presence of Vll(a), catalytically active Xa, Ca2+, and another component that appears to be associated with the lipoproteins in plasma, a lipopro-tein-associated coagulation inhibitor (LACI). A protein, LACI(HG2), possessing the same inhibitory properties as LACI, has recently been isolated from the conditioned media of cultured human liver cells (HepG2). Rabbit antisera raised against a synthetic peptide based on the N-terminal sequence of LACI(HG2) and purified IgG from a rabbit immunized with intact LACI(HG2) inhibit the LACI activity in human serum. In a reaction mixture containing Vila, Xa, Ca2+, and purified LACI(HG2), the apparent half-life (t1/2) for TF activity was 20 seconds. The presence of heparin accelerated the initial rate of inhibition threefold. Antithrombin IIIα alone had no effect, but antithrombin IIIα with heparin abrogated the TF inhibition. LACI(HG2) also inhibited Xa with an apparent t1/2of 50 seconds. Heparin enhanced the rate of Xa inhibition 2.5-fold, whereas phos-pholipids and Ca2+slowed the reaction 2.5-fold. Xa inhibition was demonstrable with both chromogenic substrate (S-2222) and bioassays, but no complex between Xa and LACI(HG2) could be visualized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). Nondena-turing PAGE, however, showed that LACI(HG2) bound to Xa but not to X or Xa inactivated by diisopropyl fluorophosphate. Thus, LACI(HG2) appears to bind to Xa at or near its active site. Bovine factor Xa lacking its γ-carboxyglutamic acid-containing domain, BXa(-GD), through treatment with a-chymotrypsin, was used to further investigate the Xa requirement for Vlla/TF inhibition by LACI(HG2). LACI(HG2) bound to BXa(-GD) and inhibited its catalytic activity against a small molecular substrate (Spectrozyme Xa), though at a rate approximately sevenfold slower than native BXa. Preincubation of LACI(HG2) with saturating concentrations of BXa(-GD) markedly retarded the subsequent inhibition of BXa. The VII(a)/TF complex was not inhibited by LACI(HG2) in the presence of BXa(-GD), and further, preincubation of LACI(HG2) with BXa(-GD) slowed the inhibition of Vlla/TF after the addition of native Xa. The results are consistent with the hypothesis that inhibition of VII(a)/TF involves the formation of a Vlla-TF-Xa-LACI complex that requires the GD of Xa. Because the GD contains the a-carboxyglutamic acids required for the Ca2+-dependent binding of factor Xa to phospholipid surfaces, the results also suggest that Ca2+ may be required for the native Xa-LACI complex to bind to and inhibit VII(a)/TF. LACI is a novel inhibitor that can rapidly affect feedback inhibition of the Vlla-Ca2+-TF enzymatic complex after the generation of small amounts of Xa and probably plays an important role in the regulation of in vivo coagulation.1988 by Grune & Stratton, Inc. 0006-4971/88/7102-0004$3.00/0

Published
1988
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40. HE COME UP FOR THE DAY.

Author

Warren, Louise

Subjects
HE Come Up For the Day (Poem), WARREN, Louise
Abstract

The poem "HE COME UP FOR THE DAY" by Louise Warren is presented. First Line: He come up for the day. Last Line: it woke him, and he swore, and made for home.

Published
2018

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