Author: "Wang, TJ" - Searchworks@Jio Institute Digital Library Search Results

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1,226 results on '"Wang, TJ"'

1. Unveiling the Hidden Risks: An Update Decade-Long Analysis of Abraxane-Related Adverse Events from the FAERS Database

Author: Zhao YC, Li X, Wang CQ, Jiao Y, Shen YN, Wang TJ, and Zhang CH
Subjects: abraxane, faers database, adverse events, signal detection, pharmacovigilance., Medicine (General), R5-920
Abstract: Yue-Chen Zhao,1,2 Xin Li,3 Chao-Qun Wang,4 Yan Jiao,5 Yan-Nan Shen,2 Tie-Jun Wang,1,2,&ast; Chao-He Zhang6,&ast; 1Department of Radiation Oncology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, People’s Republic of China; 3Department of Radiology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 4Department of Gynaecology, Aviation General Hospital, Beijing, People’s Republic of China; 5Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, First Hospital of Jilin University, Changchun, People’s Republic of China; 6Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun, Jilin, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Tie-Jun Wang, Department of Radiation Oncology, The Second Hospital of Jilin University, NO. 218 Ziqiang Street, Changchun, 130041, People’s Republic of China, Email tjwang@jlu.edu.cn Chao-He Zhang, Department of Hematology and Oncology, The Second Hospital of Jilin University, NO. 218 Ziqiang Street, Changchun, 130041, People’s Republic of China, Email zhangchaohe@jlu.edu.cnPurpose: Abraxane (nanoparticle albumin-bound paclitaxel) is a chemotherapeutic employed commonly for the management of various cancers including breast cancer, non-small cell lung cancer, and pancreatic adenocarcinoma. Although it has clinically beneficial properties, Abraxane is accompanied by multiple adverse events (AEs) that require close observation. This study aims to evaluate the AE profile of Abraxane using recently available data from January 2004 through December 2023 in the FDA Adverse Event Reporting System (FAERS).Patients and Methods: The data for Abraxane-related AEs were obtained from the FAERS database. The dataset consisted of patient demographic characteristics as well as information on the types and outcomes of AEs reported. Reporting odds ratios (ROR) as well as proportional reporting ratio (PRR), considering the used definition of anti-cancer agent and AEs, were calculated to investigate any association with Abraxane.Results: A total of 10,310 reports associated with Abraxane AEs were identified. Blood and lymphatic system disorders were the most frequent (ROR 6.44), followed by hepatobiliary (ROR 3.16), infections (ROR 1.45), and gastrointestinal disorders (ROR 1.42). Serious outcomes included hospitalization in 36.35% and death in 29.76% of cases. The top adverse reactions matched known profiles, including peripheral sensory neuropathy (ROR: 49.48). The analysis also found new adverse reactions, such as scleroderma-like reactions (ROR: 95.4) and vascular pseudoaneurysm ruptures (ROR: 87.71).Conclusion: Our results re-emphasize the importance of a robust Post Marketing Surveillance system and suggest this FAERS database based analysis provides an updated, independent information on Abraxane related AEs to enrich its safety profile. A process of continuous vigilance and additional investigations on specific areas that may have some undesired events are imperative to increase our knowledge on how Abraxane should be handled in terms of its safety.Keywords: Abraxane, FAERS database, adverse events, signal detection, pharmacovigilance
Published: 2024

2. Assessing photochemical ozone formation in the Pearl River Delta with a photochemical trajectory model

Author: Cheng, HR, Guo, H, Saunders, SM, Lam, SHM, Jiang, F, Wang, XM, Simpson, IJ, Blake, DR, Louie, PKK, and Wang, TJ
Subjects: Master chemical mechanism, Ozone, Pearl River Delta, Photochemical ozone creation potential, Meteorology & Atmospheric Sciences, Environmental Engineering, Atmospheric Sciences, Statistics
Abstract: A photochemical trajectory model (PTM), coupled with the Master Chemical Mechanism (MCM) describing the degradation of 139 volatile organic compounds (VOCs) in the troposphere, was developed and used for the first time to simulate the formation of photochemical pollutants at Wangqingsha (WQS), Guangzhou during photochemical pollution episodes between 12 and 17 November, 2007. The simulated diurnal variations and mixing ratios of ozone were in good agreement with observed data (R2=0.80, P
Published: 2010

3. Carbonyl sulfide, dimethyl sulfide and carbon disulfide in the Pearl River Delta of southern China: Impact of anthropogenic and biogenic sources

Author: Guo, H, Simpson, IJ, Ding, AJ, Wang, T, Saunders, SM, Wang, TJ, Cheng, HR, Barletta, B, Meinardi, S, Blake, DR, and Rowland, FS
Subjects: Reduced sulfur compounds, OCS, CS2, DMS, Greater Pearl River Delta, Meteorology & Atmospheric Sciences, Statistics, Atmospheric Sciences, Environmental Engineering
Abstract: Reduced sulfur compounds (RSCs) such as carbonyl sulfide (OCS), dimethyl sulfide (DMS) and carbon disulfide (CS2) impact radiative forcing, ozone depletion, and acid rain. Although Asia is a large source of these compounds, until now a long-term study of their emission patterns has not been carried out. Here we analyze 16 months of RSC data measured at a polluted rural/coastal site in the greater Pearl River Delta (PRD) of southern China. A total of 188 canister air samples were collected from August 2001 to December 2002. The OCS and CS2 mixing ratios within these samples were higher in autumn/winter and lower in summer due to the influence of Asian monsoon circulations. Comparatively low DMS values observed in this coastal region suggest a relatively low biological productivity during summer months. The springtime OCS levels in the study region (574 ± 40 pptv) were 25% higher than those on other East Asia coasts such Japan, whereas the springtime CS2 and DMS mixing ratios in the PRD (47 ± 38 pptv and 22 ± 5 pptv, respectively) were 3-30 times lower than elevated values that have been measured elsewhere in East Asia (Japan and Korea) at this time of year. Poor correlations were found among the three RSCs in the whole group of 188 samples, suggesting their complex and variable sources in the region. By means of backward Lagrangian particle release simulations, air samples originating from the inner PRD, urban Hong Kong and South China Sea were identified. The mean mixing ratio of OCS in the inner PRD was significantly higher than that in Hong Kong urban air and South China Sea marine air (p < 0.001), whereas no statistical differences were found for DMS and CS2 among the three regions (p > 0.05). Using a linear regression method based on correlations with the urban tracer CO, the estimated OCS emission in inner PRD (49.6 ± 4.7 Gg yr-1) was much higher than that in Hong Kong (0.32 ± 0.05 Gg yr-1), whereas the estimated CS2 and DMS emissions in the study region accounted for a very few percentage of the total CS2 and DMS emission in China. These findings lay the foundation for better understanding sulfur chemistry in the greater PRD region of southern China. © 2010 Elsevier Ltd.
Published: 2010

4. An ozone episode in the Pearl River Delta: Field observation and model simulation

Author: Jiang, F, Guo, H, Wang, TJ, Cheng, HR, Wang, XM, Simpson, IJ, Ding, AJ, Saunders, SM, Lam, SHM, and Blake, DR
Subjects: Earth Sciences, Atmospheric Sciences, Meteorology & Atmospheric Sciences
Abstract: In the fall of 2007 concurrent air sampling field measurements were conducted for the first time in Guangzhou (at Wan Qing Sha (WQS)) and Hong Kong (at Tung Chung (TC)), two cities in the rapidly developing Pearl River Delta region of China that are only 62 km apart. This region is known to suffer from poor air quality, especially during the autumn and winter months, when the prevailing meteorological conditions bring an outflow of continental air to the region. An interesting multiday O3 pollution event (daily maximum O3 > 122 ppbv) was captured during 9-17 November at WQS, while only one O3 episode day (10 November) was observed at TC during this time. The mean O3 mixing ratios at TC and WQS during the episode were 38 3 (mean 95% confidence interval) and 51 7 ppbv, respectively, with a mean difference of 13 ppbv and a maximum hourly difference of 150 ppbv. We further divided this event into two periods: 9-11 November as Period 1 and 12-17 November as Period 2. The mixing ratios of O3 and its precursors (NOx and CO) showed significant differences between the two periods at TC. By contrast, no obvious difference was found at WQS, indicating that different air masses arrived at TC for the two periods, as opposed to similar air masses at WQS for both periods. The analysis of VOC ratios and their relationship with O3 revealed strong O3 production at WQS during Period 2, in contrast to relatively weak photochemical O3 formation at TC. The weather conditions implied regional transport of O 3 pollution during Period 1 at both sites. Furthermore, a comprehensive air quality model system (Weather Research and Forecasting-Community Multiscale Air Quality model (WRF-CMAQ)) was used to simulate this O3 pollution event. The model system generally reproduced the variations of weather conditions, simulated well the continuous high O3 episode event at WQS, and captured fairly well the elevated O3 mixing ratios in Period 1 and low O3 levels in Period 2 at TC. The modeled surface O3 distributions and flow structures clearly illustrated the occurrence of O3 formation and the impact of regional transport on O3 levels in Period 1 in the Pearl River Delta. Further analysis of O3 formation indicated that horizontal transport was the main contributor to the O3 increase at TC during Period 1, while at WQS O3 levels were dominated by photochemical production during both periods. The low O3 levels at TC during Period 2 were attributable to lower temperatures and the arrival of fresh maritime air masses brought in by strong easterly winds. This study highlights how contrasting precursor concentrations and photochemical conditions can occur over a very small distance, and it provides a rare opportunity to better understand ozone production and precursor source origins on a finer scale in this region. © 2010 by the American Geophysical Union.
Published: 2010

5. Measurement of e(+)e(-) -> omega pi(+)pi(-) cross section at s=2.000 to 3.080 GeV

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Ahmed, S, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Batozskaya, V, Becker, D, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Brueggemann, A, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, C, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, T, Chen, Xr, Chen, Xt, Chen, Yb, Chen, Zj, Cheng, Ws, Cibinetto, G, Cossio, F, Cui, Jj, Dai, Hl, Dai, Jp, Dai, Xc, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Egorov, P, Fan, Yl, Fang, J, Fang, Ss, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fischer, K, Fritsch, M, Cd, Fu, Gao, Yn, Gao, Y, Garzia, I, Pt, Ge, Geng, C, Gersabeck, Em, Gilman, A, Goetzen, K, Gong, L, Gong, Wx, Gradl, W, Greco, M, Mh, Gu, Guan, Cy, Guo, Aq, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kk, He, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Holtmann, T, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Jf, Hu, Hu, T, Hu, Y, Huang, Gs, Huang, Kx, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Imoehl, W, Irshad, M, Jaeger, S, Janchiv, S, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jiang, Hb, Jiang, Ss, Jiang, Xs, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Kavatsyuk, M, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Kliemt, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemmel, M, Kuessner, M, Kupsc, A, Kurth, Mg, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, F, Li, G, Li, H, Hb, Li, Hj, Li, Hn, Li, Jl, Li, Jq, Li, Js, Li, Li, K, Lj, Li, Lk, Li, Li, L, Mh, Li, Pr, Li, Sx, Li, Sy, Li, Li, T, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Li, X, Zy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Lin, Dx, Lin, T, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Gm, Liu, Hm, Liu, H, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, T, Liu, Wm, Liu, X, Liu, Y, Liu, Yb, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jd, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Zh, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Lyu, Yf, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xx, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Messchendorp, Jg, Mezzadri, G, Miao, H, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Muramatsu, H, Nakhoul, S, Nefedov, Y, Nerling, F, Nikolaev, Ib, Ning, Z, Nisar, S, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Pelizaeus, M, Peng, Hp, Peters, K, Pettersson, J, Ping, Jl, Ping, Rg, Plura, S, Pogodin, S, Poling, R, Prasad, V, Qi, H, Hr, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Jj, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Ravindran, K, Redmer, Cf, Ren, Kj, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Rump, M, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Ky, Shan, W, Shan, Xy, Shangguan, Jf, Shao, Lg, Shao, M, Shen, Cp, Shen, Hf, Shen, Xy, Shi, Ba, Shi, Hc, Shi, Rs, Shi, X, Shi, Xd, Song, Jj, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Stieler, F, Kx, Su, Pp, Su, Yj, Su, Sun, Gx, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Tao, Ly, Tao, Qt, Teng, Jx, Thoren, V, Tian, Wh, Tian, Yt, Uman, I, Wang, B, Wang, Dy, Wang, F, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Yd, Wang, Yf, Wang, Yq, Wang, Yy, Wang, Y, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Xh, Wu, Wu, Y, Wu, Z, Xia, L, Xiang, T, Xiao, H, Xiao, Sy, Xiao, Yl, Xiao, Zj, Xie, Xh, Xie, Yg, Xie, Yh, Xie, Zp, Xing, Ty, Cf, Xu, Cj, Xu, Gf, Xu, Qj, Xu, Sy, Xu, Xu, W, Xp, Xu, Yc, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yang, Hj, Yang, Hx, Yang, L, Yang, Sl, Yang, Yx, Yang, Y, Yang, Z, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Js, Yu, Yu, T, Yuan, Cz, Yuan, L, Yuan, Sc, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, X, Zeng, Y, Zhan, Yh, Zhang, Aq, Zhang, Bl, Zhang, Bx, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jy, Zhang, Jz, Zhang, J, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, P, Zhang, S, Zhang, Xd, Zhang, Xm, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhong, X, Zhou, Lp, Zhou, Q, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhou, Yz, Zhu, An, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Sh, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, and Zou, Jh
Subjects: Vector Boson Production, e(+)-e(-) Experiments, Particle and Resonance Production
Published: 2023

6. Search for the lepton flavor violating decay J/psi -> e mu

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Batozskaya, V, Becker, D, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Brueggemann, A, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, C, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, Sm, Chen, T, Chen, Xr, Chen, Xt, Chen, Yb, Chen, Zj, Cheng, Ws, Chu, X, Cibinetto, G, Cossio, F, Cui, Jj, Dai, Hl, Dai, Jp, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Egorov, P, Fan, Yl, Fang, J, Fang, Ss, Fang, Wx, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fischer, K, Fritsch, M, Fritzsch, C, Cd, Fu, Gao, H, Gao, Yn, Gao, Y, Garbolino, S, Garzia, I, Pt, Ge, Zw, Ge, Geng, C, Gersabeck, Em, Gilman, A, Goetzen, K, Gong, L, Gong, Wx, Gradl, W, Greco, M, Lm, Gu, Mh, Gu, Yt, Gu, Guan, Cy, Guo, Aq, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kk, He, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Jf, Hu, Hu, T, Hu, Y, Huang, Gs, Huang, Kx, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Imoehl, W, Irshad, M, Jackson, J, Jaeger, S, Janchiv, S, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jia, Zk, Jiang, Hb, Jiang, Ss, Jiang, Xs, Jiang, Y, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Kavatsyuk, M, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Kliemt, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemme, M, Kuessner, M, Kupsc, A, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, F, Li, G, Li, H, Hb, Li, Hj, Li, Hn, Li, Jq, Li, Js, Li, Jw, Li, Li, K, Lj, Li, Lk, Li, Li, L, Mh, Li, Pr, Li, Sx, Li, Sy, Li, Li, T, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Xy, Li, Zy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Lin, Dx, Lin, T, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Gm, Liu, H, Liu, Hb, Liu, Hm, Liu, Hh, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, T, Liu, Wk, Liu, Wm, Liu, X, Liu, Y, Liu, Yb, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Zh, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Lyu, Yf, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Messchendorp, Jg, Mezzadri, G, Miao, H, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Nefedov, Y, Nerling, F, Nikolaev, Ib, Ning, Z, Nisar, S, Niu, Y, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Pelizaeus, M, Peng, Hp, Peters, K, Ping, Jl, Ping, Rg, Plura, S, Pogodin, S, Prasad, V, Fz, Qi, Qi, H, Hr, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Jj, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Redmer, Cf, Ren, Kj, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Ruan, Sn, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Ky, Shan, W, Shan, Xy, Shangguan, Jf, Shao, Lg, Shao, M, Shen, Cp, Shen, Hf, Shen, Xy, Shi, Ba, Shi, Hc, Shi, Jy, Shi, Qq, Shi, Rs, Shi, X, Shi, Xd, Song, Jj, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Stieler, F, Kx, Su, Pp, Su, Yj, Su, Sun, Gx, Sun, H, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Tao, Ly, Tao, Qt, Tat, M, Teng, Jx, Thoren, V, Tian, Wh, Tian, Y, Uman, I, Wang, B, Wang, Bl, Wang, Cw, Wang, Dy, Wang, F, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, T, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Y, Wang, Yd, Wang, Yf, Wang, Yh, Wang, Yq, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Xh, Wu, Wu, Y, Yj, Wu, Wu, Z, Xia, L, Xiang, T, Xiao, D, Xiao, Gy, Xiao, H, Xiao, Sy, Xiao, Yl, Xiao, Zj, Xie, C, Xie, Xh, Xie, Y, Xie, Yg, Xie, Yh, Xie, Zp, Xing, Ty, Cf, Xu, Cj, Xu, Gf, Xu, Hy, Xu, Qj, Xu, Xp, Xu, Yc, Xu, Zp, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yang, Hj, Yang, Hl, Yang, Hx, Yang, L, Yang, Sl, Yang, T, Yang, Yf, Yang, Yx, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Yu, T, Yuan, Cz, Yuan, L, Yuan, Sc, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, Fr, Zeng, X, Zeng, Y, Zhan, Yh, Zhang, Aq, Zhang, Bl, Zhang, Bx, Zhang, Dh, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jx, Zhang, Jy, Zhang, Jz, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, P, Zhang, Qy, Zhang, Sh, Zhang, Sl, Zhang, Xd, Zhang, Xm, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhong, X, Zhou, H, Zhou, Lp, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhou, Yz, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Lx, Zhu, Sh, Zhu, Sq, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, Zou, Jh, Energy and Sustainability Research Institute Groni, and Nuclear Energy
Subjects: e(+)e(-) experiments, charmonium, General Physics and Astronomy, BESIII, lepton flavor violating decay
Abstract: We present a search for the lepton flavor violating decay J/ψ → e±μ∓ using 8.998 × 109J/ψ events collected with the BESIII detector at the BEPCII e+e− storage ring. No excess of signal above background is observed; we therefore set an upper limit on the branching fraction of B(J/ψ→e±μ∓)
Published: 2023

7. Host and gut microbial tryptophan metabolism and type 2 diabetes: An integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

Author: Universitat Rovira i Virgili, Qi Q; Li J; Yu B; Moon JY; Chai JC; Merino J; Hu J; Ruiz-Canela M; Rebholz C; Wang Z; Usyk M; Chen GC; Porneala BC; Wang W; Nguyen NQ; Feofanova EV; Grove ML; Wang TJ; Gerszten RE; Dupuis J; Salas-Salvadó J; Bao W; Perkins DL; Daviglus ML; Thyagarajan B; Cai J; Wang T; Manson JAE; Martínez-González MA; Selvin E; Rexrode KM; Clish CB; Hu FB; Meigs JB; Knight R; Burk RD; Boerwinkle E; Kaplan RC, Universitat Rovira i Virgili, and Qi Q; Li J; Yu B; Moon JY; Chai JC; Merino J; Hu J; Ruiz-Canela M; Rebholz C; Wang Z; Usyk M; Chen GC; Porneala BC; Wang W; Nguyen NQ; Feofanova EV; Grove ML; Wang TJ; Gerszten RE; Dupuis J; Salas-Salvadó J; Bao W; Perkins DL; Daviglus ML; Thyagarajan B; Cai J; Wang T; Manson JAE; Martínez-González MA; Selvin E; Rexrode KM; Clish CB; Hu FB; Meigs JB; Knight R; Burk RD; Boerwinkle E; Kaplan RC
Abstract: Objective: Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet and gut microbiota. Method: We analysed associations between circulating levels of 11 tryptophan metabolites and incident T2D in 9180 participants of diverse racial/ethnic backgrounds from five cohorts. We examined host genome-wide variants, dietary intake and gut microbiome associated with these metabolites. Results: Tryptophan, four kynurenine-pathway metabolites (kynurenine, kynurenate, xanthurenate and quinolinate) and indolelactate were positively associated with T2D risk, while indolepropionate was inversely associated with T2D risk. We identified multiple host genetic variants, dietary factors, gut bacteria and their potential interplay associated with these T2D-relaetd metabolites. Intakes of fibre-rich foods, but not protein/tryptophan-rich foods, were the dietary factors most strongly associated with tryptophan metabolites. The fibre-indolepropionate association was partially explained by indolepropionate-associated gut bacteria, mostly fibre-using Firmicutes. We identified a novel association between a host functional LCT variant (determining lactase persistence) and serum indolepropionate, which might be related to a host gene-diet interaction on gut Bifidobacterium, a probiotic bacterium significantly associated with indolepropionate independent of other fibre-related bacteria. Higher milk intake was associated with higher levels of gut Bifidobacterium and serum indolepropionate only among genetically lactase non-persistent individuals. Conclusion: Higher milk intake among lactase non-persistent individuals
Published: 2022

8. Measurement of e(+)e(-) -> pi(+)pi(-) D+D- cross sections at center-of-mass energies from 4.190 to 4.946 GeV

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Batozskaya, V, Becker, D, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Brueggemann, A, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, C, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, Sm, Chen, T, Chen, Xr, Chen, Xt, Chen, Yb, Chen, Zj, Cheng, Ws, Choi, Sk, Chu, X, Cibinetto, G, Cossio, F, Cui, Jj, Dai, Hl, Dai, Jp, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Egorov, P, Fan, Yl, Fang, J, Fang, Ss, Fang, Wx, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fischer, K, Fritsch, M, Fritzsch, C, Cd, Fu, Gao, H, Gao, Yn, Gao, Y, Garbolino, S, Garzia, I, Pt, Ge, Zw, Ge, Geng, C, Gersabeck, Em, Gilman, A, Gong, L, Gong, Wx, Gradl, W, Greco, M, Lm, Gu, Mh, Gu, Yt, Gu, Guan, Cy, Guo, Aq, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kk, He, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Jf, Hu, Hu, T, Hu, Y, Huang, Gs, Huang, Kx, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Imoehl, W, Irshad, M, Jackson, J, Jaeger, S, Janchiv, S, Jang, E, Jeong, Jh, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jia, Zk, Jiang, Hb, Jiang, Ss, Jiang, Xs, Jiang, Y, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Kavatsyuk, M, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemmel, M, Kuessner, M, Kupsc, A, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, F, Li, G, Li, H, Hb, Li, Hj, Li, Hn, Li, Jq, Li, Js, Li, Jw, Li, Li, K, Lj, Li, Lk, Li, Li, L, Mh, Li, Pr, Li, Sx, Li, Sy, Li, Li, T, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Xy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Lin, Dx, Lin, T, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Gm, Liu, H, Liu, Hb, Liu, Hm, Liu, Hh, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, T, Liu, Wk, Liu, Wm, Liu, X, Liu, Y, Liu, Yb, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Zh, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Lyu, Yf, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Mezzadri, G, Miao, H, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Nefedov, Y, Nerling, F, Nikolaev, Ib, Ning, Z, Nisar, S, Niu, Y, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Pelizaeus, M, Peng, Hp, Pettersson, J, Ping, Jl, Ping, Rg, Plura, S, Pogodin, S, Prasad, V, Fz, Qi, Qi, H, Hr, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Jj, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Redmer, Cf, Ren, Kj, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Ruan, Sn, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Ky, Shan, W, Shan, Xy, Shangguan, Jf, Shao, Lg, Shao, M, Shen, Cp, Shen, Hf, Shen, Xy, Shi, Ba, Shi, Hc, Shi, Jy, Shi, Qq, Shi, Rs, Shi, X, Shi, Xd, Song, Jj, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Stieler, F, Kx, Su, Pp, Su, Yj, Su, Sun, Gx, Sun, H, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Tao, Ly, Tao, Qt, Tat, M, Teng, Jx, Thoren, V, Tian, Wh, Tian, Y, Uman, I, Wang, B, Wang, Bl, Wang, Cw, Wang, Dy, Wang, F, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, T, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Yd, Wang, Yf, Wang, Yh, Wang, Yq, Wang, Y, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Xh, Wu, Wu, Y, Wu, Z, Xia, L, Xiang, T, Xiao, D, Xiao, Gy, Xiao, H, Xiao, Sy, Xiao, Yl, Xiao, Zj, Xie, C, Xie, Xh, Xie, Y, Xie, Yg, Xie, Yh, Xie, Zp, Xing, Ty, Cf, Xu, Cj, Xu, Gf, Xu, Hy, Xu, Qj, Xu, Sy, Xu, Xp, Xu, Yc, Xu, Zp, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yang, Hj, Yang, Hl, Yang, Hx, Yang, L, Yang, Sl, Yang, T, Yang, Yf, Yang, Yx, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Yu, T, Xd, Yu, Yuan, Cz, Yuan, L, Yuan, Sc, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, Fr, Zeng, X, Zeng, Y, Zhan, Yh, Zhang, Aq, Zhang, Bl, Zhang, Bx, Zhang, Dh, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jx, Zhang, Jy, Zhang, Jz, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, P, Zhang, Qy, Zhang, Sl, Zhang, Xd, Zhang, Xm, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhong, X, Zhou, H, Zhou, Lp, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhou, Yz, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Lx, Zhu, Sh, Zhu, Sq, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, and Zou, Jh
Published: 2022

9. Search for the semileptonic decay D-s(+) -> pi(0)e(+)nu(e)

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Batozskaya, V, Becker, D, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Brueggemann, A, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, C, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, Sm, Chen, T, Chen, Xr, Chen, Xt, Chen, Yb, Chen, Zj, Cheng, Ws, Chu, X, Cibinetto, G, Cossio, F, Cui, Jj, Dai, Hl, Dai, Jp, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Egorov, P, Fan, Yl, Fang, J, Fang, Ss, Fang, Wx, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fischer, K, Fritsch, M, Fritzsch, C, Cd, Fu, Gao, H, Gao, Yn, Gao, Y, Garbolino, S, Garzia, I, Pt, Ge, Zw, Ge, Geng, C, Gersabeck, Em, Gilman, A, Goetzen, K, Gong, L, Gong, Wx, Gradl, W, Greco, M, Lm, Gu, Mh, Gu, Guan, Cy, Guo, Aq, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kk, He, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Hu, Jifeng, Hu, T, Hu, Y, Huang, Gs, Huang, Kx, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Imoehl, W, Irshad, M, Jackson, J, Jaeger, S, Janchiv, S, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jia, Zk, Jiang, Hb, Jiang, Ss, Jiang, Xs, Jiang, Y, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Kavatsyuk, M, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Kliemt, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemmel, M, Kuessner, M, Kupsc, A, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, F, Li, G, Li, H, Hb, Li, Hj, Li, Hn, Li, Jq, Li, Js, Li, Jw, Li, Li, K, Lj, Li, Lk, Li, Li, L, Mh, Li, Pr, Li, Sx, Li, Sy, Li, Li, T, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Xy, Li, Zy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Lin, Dx, Lin, T, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Gm, Liu, H, Liu, Hm, Liu, Hh, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, T, Liu, Wk, Liu, Wm, Liu, X, Liu, Y, Liu, Yb, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Zh, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Lyu, Yf, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Messchendorp, Jg, Mezzadri, G, Miao, H, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Nefedov, Y, Nikolaev, Ib, Ning, Z, Nisar, S, Niu, Y, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Pelizaeus, M, Peng, Hp, Peters, K, Pettersson, J, Ping, Jl, Ping, Rg, Plura, S, Pogodin, S, Prasad, V, Fz, Qi, Qi, H, Hr, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Jj, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Redmer, Cf, Ren, Kj, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Ruan, Sn, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Ky, Shan, W, Shan, Xy, Shangguan, Jf, Shao, Lg, Shao, M, Shen, Cp, Shen, Hf, Shen, Xy, Shi, Ba, Shi, Hc, Shi, Jy, Shi, Qq, Shi, Rs, Shi, X, Shi, Xd, Song, Jj, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Stieler, F, Kx, Su, Pp, Su, Yj, Su, Sun, Gx, Sun, H, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Tao, Ly, Tao, Qt, Tat, M, Teng, Jx, Thoren, V, Tian, Wh, Tian, Y, Uman, I, Wang, B, Wang, Bl, Wang, Cw, Wang, Dy, Wang, F, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, T, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Yd, Wang, Yf, Wang, Yh, Wang, Yq, Wang, Y, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Xh, Wu, Wu, Y, Wu, Z, Xia, L, Xiang, T, Xiao, D, Xiao, Gy, Xiao, H, Xiao, Sy, Xiao, Yl, Xiao, Zj, Xie, C, Xie, Xh, Xie, Y, Xie, Yg, Xie, Yh, Xie, Zp, Xing, Ty, Cf, Xu, Cj, Xu, Gf, Xu, Hy, Xu, Qj, Xu, Sy, Xu, Xp, Xu, Yc, Xu, Zp, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yang, Hj, Yang, Hl, Yang, Hx, Yang, L, Yang, Sl, Yang, T, Yang, Yx, Yang, Yf, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Yu, T, Yuan, Cz, Yuan, L, Yuan, Sc, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, Fr, Zeng, X, Zeng, Y, Zhan, Yh, Zhang, Aq, Zhang, Bl, Zhang, Bx, Zhang, Dh, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jx, Zhang, Jy, Zhang, Jz, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, P, Zhang, Qy, Zhang, Sl, Zhang, Xd, Zhang, Xm, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhong, X, Zhou, H, Zhou, Lp, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhou, Yz, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Lx, Zhu, Sh, Zhu, Sq, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, and Zou, Jh
Published: 2022

10. Search for X(3872) -> pi(0)chi(c0) and X(3872) -> pi pi chi(c0) at BESIII

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Batozskaya, V, Becker, D, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Brueggemann, A, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, C, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, Sm, Chen, T, Chen, Xr, Chen, Xt, Chen, Yb, Chen, Zj, Cheng, Ws, Chu, X, Cibinetto, G, Cossio, F, Cui, Jj, Dai, Hl, Dai, Jp, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Egorov, P, Fan, Yl, Fang, J, Fang, Ss, Fang, Wx, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fischer, K, Fritsch, M, Fritzsch, C, Cd, Fu, Gao, H, Gao, Yn, Gao, Y, Garbolino, S, Garzia, I, Pt, Ge, Zw, Ge, Geng, C, Gersabeck, Em, Gilman, A, Goetzen, K, Gong, L, Gong, Wx, Gradl, W, Greco, M, Lm, Gu, Mh, Gu, Guan, Cy, Guo, Aq, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kk, He, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Hu, Jifeng, Hu, T, Hu, Y, Huang, Gs, Huang, Kx, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Imoehl, W, Irshad, M, Jackson, J, Jaeger, S, Janchiv, S, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jia, Zk, Jiang, Hb, Jiang, Ss, Jiang, Xs, Jiang, Y, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Kavatsyuk, M, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Kliemt, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemmel, M, Kuessner, M, Kupsc, A, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, F, Li, G, Li, H, Hb, Li, Hj, Li, Hn, Li, Jq, Li, Js, Li, Jw, Li, Li, K, Lj, Li, Lk, Li, Li, L, Mh, Li, Pr, Li, Sx, Li, Sy, Li, Li, T, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Xy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Lin, Dx, Lin, T, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Gm, Liu, H, Liu, Hm, Liu, Hh, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, T, Liu, Wk, Liu, Wm, Liu, X, Liu, Y, Liu, Yb, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Zh, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Lyu, Yf, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Messchendorp, Jg, Mezzadri, G, Miao, H, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Nefedov, Y, Nikolaev, Ib, Ning, Z, Nisar, S, Niu, Y, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Pelizaeus, M, Peng, Hp, Peters, K, Pettersson, J, Ping, Jl, Ping, Rg, Plura, S, Pogodin, S, Prasad, V, Fz, Qi, Qi, H, Hr, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Jj, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Redmer, Cf, Ren, Kj, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Ruan, Sn, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Ky, Shan, W, Shan, Xy, Shangguan, Jf, Shao, Lg, Shao, M, Shen, Cp, Shen, Hf, Shen, Xy, Shi, Ba, Shi, Hc, Shi, Jy, Shi, Qq, Shi, Rs, Shi, X, Shi, Xd, Song, Jj, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Stieler, F, Kx, Su, Pp, Su, Yj, Su, Sun, Gx, Sun, H, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Tao, Ly, Tao, Qt, Tat, M, Teng, Jx, Thoren, V, Tian, Wh, Tian, Y, Uman, I, Wang, B, Wang, Bl, Wang, Cw, Wang, Dy, Wang, F, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, T, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Yd, Wang, Yf, Wang, Yh, Wang, Yq, Wang, Y, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Xh, Wu, Wu, Y, Wu, Z, Xia, L, Xiang, T, Xiao, D, Xiao, Gy, Xiao, H, Xiao, Sy, Xiao, Yl, Xiao, Zj, Xie, C, Xie, Xh, Xie, Y, Xie, Yg, Xie, Yh, Xie, Zp, Xing, Ty, Cf, Xu, Cj, Xu, Gf, Xu, Hy, Xu, Qj, Xu, Sy, Xu, Xp, Xu, Yc, Xu, Zp, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yang, Hj, Yang, Hl, Yang, Hx, Yang, L, Yang, Sl, Yang, T, Yang, Yx, Yang, Yf, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Yu, T, Yuan, Cz, Yuan, L, Yuan, Sc, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, Fr, Zeng, Xz, Zeng, Y, Zhan, Yh, Zhang, Aq, Zhang, Bl, Zhang, Bx, Zhang, Dh, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jx, Zhang, Jy, Zhang, Jz, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, P, Zhang, Qy, Zhang, Sl, Zhang, Xd, Zhang, Xm, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhong, X, Zhou, H, Zhou, Lp, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhou, Yz, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Lx, Zhu, Sh, Zhu, Sq, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, and Zou, Jh
Published: 2022

11. Cross section measurements of the processes e(+)e(-) -> omega pi(0) and omega eta at center-of-mass energies between 3.773 and 4.701 GeV

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Ahmed, S, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Batozskaya, V, Becker, D, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, C, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, T, Chen, Xr, Chen, Xt, Chen, Yb, Chen, Zj, Cheng, Ws, Cibinetto, G, Cossio, F, Cui, Jj, Cui, Xf, Dai, Hl, Dai, Jp, Dai, Xc, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, C, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Egorov, P, Fan, Yl, Fang, J, Fang, Ss, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fritsch, M, Cd, Fu, Gao, Yn, Gao, Y, Garzia, I, Pt, Ge, Geng, C, Gersabeck, Em, Gilman, A, Goetzen, K, Gong, L, Gong, Wx, Gradl, W, Greco, M, Mh, Gu, Guan, Cy, Guo, Aq, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kk, He, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Holtmann, T, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Hu, Jifeng, Hu, T, Hu, Y, Huang, Gs, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Andersson, Wi, Imoehl, W, Irshad, M, Jaeger, S, Janchiv, S, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jiang, Hb, Jiang, Ss, Jiang, Xs, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Kavatsyuk, M, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Kliemt, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemmel, M, Kuessner, M, Kupsc, A, Kurth, Mg, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, F, Li, G, Li, H, Hb, Li, Hj, Li, Hn, Li, Jl, Li, Jq, Li, Js, Li, Li, K, Lj, Li, Lk, Li, Li, L, Mh, Li, Pr, Li, Sx, Li, Sy, Li, Li, T, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Xy, Li, Zy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Lin, Dx, Lin, T, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Gm, Liu, Hm, Liu, Hh, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, T, Liu, Wm, Liu, X, Liu, Y, Liu, Yb, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jd, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Zh, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Lyu, Yf, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xx, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Messchendorp, Jg, Mezzadri, G, Miao, H, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Muramatsu, H, Nakhoul, S, Nefedov, Y, Nerling, F, Nikolaev, Ib, Ning, Z, Nisar, S, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Patteri, P, Pelizaeus, M, Peng, Hp, Peters, K, Pettersson, J, Ping, Jl, Ping, Rg, Plura, S, Pogodin, S, Poling, R, Prasad, V, Qi, H, Hr, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Jj, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Ravindran, K, Redmer, Cf, Ren, Kj, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Rump, M, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Ky, Shan, W, Shan, Xy, Shangguan, Jf, Shao, Lg, Shao, M, Shen, Cp, Shen, Hf, Shen, Xy, Shi, Ba, Shi, Hc, Shi, Rs, Shi, X, Shi, Xd, Song, Jj, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Stieler, F, Kx, Su, Pp, Su, Yj, Su, Sun, Gx, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Tao, Ly, Tao, Qt, Teng, Jx, Thoren, V, Tian, Wh, Tian, Yt, Uman, I, Wang, B, Wang, Dy, Wang, F, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Yd, Wang, Yf, Wang, Yq, Wang, Yy, Wang, Y, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Xh, Wu, Wu, Z, Xia, L, Xiang, T, Xiao, H, Xiao, Sy, Xiao, Yl, Xiao, Zj, Xie, Xh, Xie, Yg, Xie, Yh, Xing, Ty, Cf, Xu, Cj, Xu, Gf, Xu, Qj, Xu, Sy, Xu, Xu, W, Xp, Xu, Yc, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yang, Hj, Yang, Hx, Yang, L, Yang, Sl, Yang, Yx, Yang, Yf, Yang, Z, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Js, Yu, Yu, T, Yuan, Cz, Yuan, L, Yuan, Sc, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, X, Zeng, Y, Zhang, Aq, Zhang, Bl, Zhang, Bx, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jy, Zhang, Jz, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, P, Zhang, Sl, Zhang, Xd, Zhang, Xm, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhou, Lp, Zhou, Q, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhou, Yz, Zhu, An, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Sh, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, and Zou, Jh
Subjects: Exotics, e(+)-e(-) Experiments, Particle and Resonance Production, Quarkonium
Published: 2022

12. Measurement of the e(+) e(-) -> omega pi(0)pi(0) cross section at center-of-mass energies from 2.0 to 3.08 GeV

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Batozskaya, V, Becker, D, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Brueggemann, A, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, C, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, Sm, Chen, T, Chen, Xr, Chen, Xt, Chen, Yb, Chen, Zj, Cheng, Ws, Chu, X, Cibinetto, G, Cossio, F, Cui, Jj, Dai, Hl, Dai, Jp, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Egorov, P, Fan, Yl, Fang, J, Fang, Ss, Fang, Wx, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fischer, K, Fritsch, M, Fritzsch, C, Cd, Fu, Gao, H, Gao, Yn, Gao, Y, Garbolino, S, Garzia, I, Pt, Ge, Zw, Ge, Geng, C, Gersabeck, Em, Gilman, A, Goetzen, K, Gong, L, Gong, Wx, Gradl, W, Greco, M, Lm, Gu, Mh, Gu, Guan, Cy, Guo, Aq, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kk, He, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Hu, Jifeng, Hu, T, Hu, Y, Huang, Gs, Huang, Kx, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Imoehl, W, Irshad, M, Jackson, J, Jaeger, S, Janchiv, S, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jia, Zk, Jiang, Hb, Jiang, Ss, Jiang, Xs, Jiang, Y, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Kavatsyuk, M, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Kliemt, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemmel, M, Kuessner, M, Kupsc, A, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, F, Li, G, Li, H, Hb, Li, Hj, Li, Hn, Li, Jq, Li, Js, Li, Jw, Li, Li, K, Lj, Li, Lk, Li, Li, L, Mh, Li, Pr, Li, Sx, Li, Sy, Li, Li, T, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Xy, Li, Zy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Lin, Dx, Lin, T, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Gm, Liu, H, Liu, Hm, Liu, Hh, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, T, Liu, Wk, Liu, Wm, Liu, X, Liu, Y, Liu, Yb, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Zh, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Lyu, Yf, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Messchendorp, Jg, Mezzadri, G, Miao, H, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Nefedov, Y, Nikolaev, Ib, Ning, Z, Nisar, S, Niu, Y, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Pelizaeus, M, Peng, Hp, Peters, K, Pettersson, J, Ping, Jl, Ping, Rg, Plura, S, Pogodin, S, Prasad, V, Fz, Qi, Qi, H, Hr, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Jj, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Redmer, Cf, Ren, Kj, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Ruan, Sn, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Ky, Shan, W, Shan, Xy, Shangguan, Jf, Shao, Lg, Shao, M, Shen, Cp, Shen, Hf, Shen, Xy, Shi, Ba, Shi, Hc, Shi, Jy, Shi, Qq, Shi, Rs, Shi, X, Shi, Xd, Song, Jj, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Stieler, F, Kx, Su, Pp, Su, Yj, Su, Sun, Gx, Sun, H, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Tao, Ly, Tao, Qt, Tat, M, Teng, Jx, Thoren, V, Tian, Wh, Tian, Y, Uman, I, Wang, B, Wang, Bl, Wang, Cw, Wang, Dy, Wang, F, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, T, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Yd, Wang, Yf, Wang, Yh, Wang, Yq, Wang, Y, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Xh, Wu, Wu, Y, Wu, Z, Xia, L, Xiang, T, Xiao, D, Xiao, Gy, Xiao, H, Xiao, Sy, Xiao, Yl, Xiao, Zj, Xie, C, Xie, Xh, Xie, Y, Xie, Yg, Xie, Yh, Xie, Zp, Xing, Ty, Cf, Xu, Cj, Xu, Gf, Xu, Hy, Xu, Qj, Xu, Sy, Xu, Xp, Xu, Yc, Xu, Zp, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yang, Hj, Yang, Hl, Yang, Hx, Yang, L, Yang, Sl, Yang, T, Yang, Yx, Yang, Yf, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Yu, T, Yuan, Cz, Yuan, L, Yuan, Sc, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, Fr, Zeng, Xz, Zeng, Y, Zhan, Yh, Zhang, Aq, Zhang, Bl, Zhang, Bx, Zhang, Dh, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jx, Zhang, Jy, Zhang, Jz, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, P, Zhang, Qy, Zhang, Sl, Zhang, Xd, Zhang, Xm, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhong, X, Zhou, H, Zhou, Lp, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhou, Yz, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Lx, Zhu, Sh, Zhu, Sq, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, and Zou, Jh
Published: 2022

13. Measurement of the branching fraction of the doubly Cabibbo-suppressed decay D-0 -> K+pi(-)pi(0) and search for D-0 -> K+pi(-)pi(0)pi(0)

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Batozskaya, V, Becker, D, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Brueggemann, A, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, C, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, T, Chen, Xr, Chen, Xt, Chen, Yb, Chen, Zj, Cheng, Ws, Cibinetto, G, Cossio, F, Cui, Jj, Dai, Hl, Dai, Jp, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Egorov, P, Fan, Yl, Fang, J, Fang, Ss, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fischer, K, Fritsch, M, Cd, Fu, Gao, H, Gao, Yn, Garbolino, S, Garzia, I, Pt, Ge, Zw, Ge, Geng, C, Gersabeck, Em, Gilman, A, Goetzen, K, Gong, L, Gong, Wx, Gradl, W, Greco, M, Lm, Gu, Mh, Gu, Yt, Gu, Guan, Cy, Guo, Aq, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kk, He, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Holtmann, T, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Hu, Jifeng, Hu, T, Hu, Y, Huang, Gs, Huang, Kx, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Imoehl, W, Irshad, M, Jackson, J, Jaeger, S, Janchiv, S, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jia, Zk, Jiang, Hb, Jiang, Ss, Jiang, Xs, Jiang, Y, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Kliemt, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemmel, M, Kuessner, M, Kupsc, A, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, G, Li, H, Hj, Li, Hb, Li, Hn, Li, Jq, Li, Js, Li, Jw, Li, Li, K, Lj, Li, Lk, Li, Li, L, Mh, Li, Pr, Li, Sx, Li, Sy, Li, Li, T, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Xy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Lin, Dx, Lin, T, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Gm, Liu, Hb, Liu, Hm, Liu, Hn, Liu, Hh, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Lc, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, T, Liu, Wk, Liu, Wm, Liu, X, Liu, Y, Liu, B, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Zh, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Lyu, Yf, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Messchendorp, Jg, Mezzadri, G, Miao, H, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Muramatsu, H, Nakhoul, S, Nefedov, Y, Nerling, F, Nikolaev, Ib, Ning, Z, Nisar, S, Niu, Y, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Pelizaeus, M, Peng, Hp, Peters, K, Ping, Jl, Ping, Rg, Plura, S, Pogodin, S, Poling, R, Prasad, V, Qi, H, Hr, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Jj, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Ravindran, K, Redmer, Cf, Ren, Kj, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Ky, Shan, W, Shan, Xy, Shangguan, Jf, Shao, Lg, Shao, M, Shen, Cp, Shen, Hf, Shen, Xy, Shi, Ba, Shi, Hc, Shi, Rs, Shi, X, Shi, Xd, Song, Jj, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Stieler, F, Kx, Su, Pp, Su, Yj, Su, Sun, Gx, Sun, H, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Tao, Ly, Tao, Qt, Teng, Jx, Thoren, V, Tian, Wh, Tian, Y, Uman, I, Wang, B, Wang, Bl, Wang, Cw, Wang, Dy, Wang, F, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, T, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Yd, Wang, Yf, Wang, Yh, Wang, Yq, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Xh, Wu, Wu, Y, Xia, L, Xiang, T, Xiao, Gy, Xiao, H, Xiao, Sy, Xiao, Yl, Xiao, Zj, Xie, C, Xie, Xh, Xie, Y, Xie, Yg, Xie, Yh, Xie, Zp, Xing, Ty, Cf, Xu, Cj, Xu, Gf, Xu, Hy, Xu, Qj, Xu, Xp, Xu, Yc, Xu, Zp, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yang, Hj, Yang, Hl, Yang, Hx, Yang, L, Yang, Sl, Yang, Yx, Yang, Yf, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Js, Yu, Yu, T, Yuan, Cz, Yuan, L, Yuan, Sc, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, Fr, Zeng, Xz, Zeng, Y, Zhan, Yh, Zhang, Aq, Zhang, Bl, Zhang, Bx, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jy, Zhang, Jz, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, P, Zhang, Qy, Zhang, Sh, Zhang, Sl, Zhang, Xd, Zhang, Xm, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhong, X, Zhou, H, Zhou, Lp, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhou, Yz, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Lx, Zhu, Sh, Zhu, Sq, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, and Zou, Jh
Published: 2022

14. Study of the resonance structures in the process e(+) e(-) -> pi(+) pi(-) J/psi

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Batozskaya, V, Becker, D, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Brueggemann, A, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, C, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, T, Chen, Xr, Chen, Xt, Chen, Yb, Chen, Zj, Cheng, Ws, Chu, X, Cibinetto, G, Cossio, F, Cui, Jj, Dai, Hl, Dai, Jp, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Egorov, P, Fan, Yl, Fang, J, Fang, Ss, Fang, Wx, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fischer, K, Fritsch, M, Fritzsch, Cf, Cd, Fu, Gao, H, Gao, Yn, Gao, Y, Garbolino, S, Garzia, I, Pt, Ge, Geng, C, Gersabeck, Em, Gilman, A, Goetzen, K, Gong, L, Gong, Wx, Gradl, W, Greco, M, Mh, Gu, Guan, Cy, Guo, Aq, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kk, He, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Holtmann, T, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Hu, Jifeng, Hu, T, Hu, Y, Huang, Gs, Huang, Kx, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Imoehl, W, Irshad, M, Jackson, J, Jaeger, S, Janchiv, S, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jia, Zk, Jiang, Hb, Jiang, Ss, Jiang, Xs, Jiang, Y, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Kavatsyuk, M, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Kliemt, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemmel, M, Kuessner, M, Kupsc, A, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, F, Li, G, Li, H, Hb, Li, Hj, Li, Hn, Li, Jq, Li, Js, Li, Jw, Li, Li, K, Lj, Li, Lk, Li, Li, L, Mh, Li, Pr, Li, Sx, Li, Sy, Li, Li, T, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Xy, Li, Zy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Lin, Dx, Lin, T, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Gm, Liu, H, Liu, Hm, Liu, Hh, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, T, Liu, Wk, Liu, Wm, Liu, X, Liu, Y, Liu, Yb, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Zh, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Lyu, Yf, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Messchendorp, Jg, Mezzadri, G, Miao, H, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Muramatsu, H, Nefedov, Y, Nerling, F, Nikolaev, Ib, Ning, Z, Nisar, S, Niu, Y, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Pelizaeus, M, Peng, Hp, Peters, K, Pettersson, J, Ping, Jl, Ping, Rg, Plura, S, Pogodin, S, Poling, R, Prasad, V, Fz, Qi, Qi, H, Hr, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Jj, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Redmer, Cf, Ren, Kj, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Ruan, Sn, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Ky, Shan, W, Shan, Xy, Shangguan, Jf, Shao, Lg, Shao, M, Shen, Cp, Shen, Hf, Shen, Xy, Shi, Ba, Shi, Hc, Shi, Jy, Shi, Rs, Shi, X, Shi, Xd, Song, Jj, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Stieler, F, Kx, Su, Pp, Su, Yj, Su, Sun, Gx, Sun, H, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Tao, Ly, Tao, Qt, Teng, Jx, Thoren, V, Tian, Wh, Tian, Yt, Uman, I, Wang, B, Wang, Bl, Wang, Dy, Wang, F, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, T, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Yd, Wang, Yf, Wang, Yh, Wang, Yq, Wang, Y, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Xh, Wu, Wu, Y, Wu, Z, Xia, L, Xiang, T, Xiao, D, Xiao, H, Xiao, Sy, Xiao, Yl, Xiao, Zj, Xie, Xh, Xie, Y, Xie, Yg, Xie, Yh, Xie, Zp, Xing, Ty, Cf, Xu, Cj, Xu, Gf, Xu, Qj, Xu, Sy, Xu, Xp, Xu, Yc, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yang, Hj, Yang, Hl, Yang, Hx, Yang, L, Yang, Sl, Yang, T, Yang, Yx, Yang, Yf, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Yu, T, Yuan, Cz, Yuan, L, Yuan, Sc, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, Fr, Zeng, X, Zeng, Y, Zhan, Yh, Zhang, Aq, Zhang, Bl, Zhang, Bx, Zhang, Dh, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jx, Zhang, Jy, Zhang, Jz, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, P, Zhang, Qy, Zhang, Sl, Zhang, Xd, Zhang, Xm, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhong, X, Zhou, H, Zhou, Lp, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhou, Yz, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Lx, Zhu, Sh, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, and Zou, Jh
Published: 2022

15. Search for baryon- and lepton-number violating decays D-0 -> (p)over-bare(+) and D-0 -> pe(-)

Author: Ablikim, M, Achasov, Mn, Adlarson, P, Ahmed, S, Albrecht, M, Aliberti, R, Amoroso, A, Mr, An, An, Q, Bai, Xh, Bai, Y, Bakina, O, Ferroli, Rb, Balossino, I, Ban, Y, Begzsuren, K, Berger, N, Bertani, M, Bettoni, D, Bianchi, F, Bloms, J, Bortone, A, Boyko, I, Briere, Ra, Brueggemann, A, Cai, H, Cai, X, Calcaterra, A, Cao, Gf, Cao, N, Cetin, Sa, Chang, Jf, Chang, Wl, Chelkov, G, Chen, G, Chen, Hs, Chen, Ml, Chen, Sj, Chen, Xr, Chen, Yb, Chen, Zj, Cheng, Ws, Cibinetto, G, Cossio, F, Dai, Hl, Dai, Jp, Dai, Xc, Dbeyssi, A, de Boer, Re, Dedovich, D, Deng, Zy, Denig, A, Denysenko, I, Destefanis, M, De Mori, F, Ding, Y, Dong, J, Dong, Ly, Dong, My, Dong, X, Sx, Du, Fan, Yl, Fang, J, Fang, Ss, Fang, Y, Farinelli, R, Fava, L, Feldbauer, F, Felici, G, Feng, Cq, Feng, Jh, Fritsch, M, Cd, Fu, Gao, Yn, Gao, Y, Garzia, I, Pt, Ge, Geng, C, Gersabeck, Em, Gilman, A, Goetzen, K, Gong, L, Gong, Wx, Gradl, W, Greco, M, Lm, Gu, Mh, Gu, Yt, Gu, Guan, Cy, Guo, Lb, Guo, Rp, Guo, Yp, Guskov, A, Han, Tt, Han, Wy, Hao, Xq, Harris, Fa, Kl, He, Heinsius, Fh, Heinz, Ch, Heng, Yk, Herold, C, Himmelreich, M, Holtmann, T, Hou, Gy, Hou, Yr, Hou, Zl, Hm, Hu, Hu, Jifeng, Hu, T, Hu, Y, Huang, Gs, Huang, Lq, Huang, Xt, Huang, Yp, Huang, Z, Hussain, T, Husken, N, Imoehl, W, Irshad, M, Jackson, J, Jaeger, S, Janchiv, S, Ji, Q, Qp, Ji, Xb, Ji, Xl, Ji, Yy, Ji, Jiang, Hb, Jiang, Xs, Jiang, Y, Jiao, Jb, Jiao, Z, Jin, S, Jin, Y, Jing, Mq, Johansson, T, Kalantar-Nayestanaki, N, Kang, Xs, Kappert, R, Kavatsyuk, M, Bc, Ke, Keshk, Ik, Khoukaz, A, Kiese, P, Kiuchi, R, Kliemt, R, Koch, L, Kolcu, Ob, Kopf, B, Kuemmel, M, Kuessner, M, Kupsc, A, Kurth, Mg, Kuhn, W, Lane, Jj, Lange, Js, Larin, P, Lavania, A, Lavezzi, L, Lei, Zh, Leithoff, H, Lellmann, M, Lenz, T, Li, C, Ch, Li, Dm, Li, Li, F, Li, G, Li, H, Hb, Li, Hj, Li, Jq, Li, Js, Li, Jw, Li, Li, K, Lk, Li, Li, L, Pr, Li, Sy, Li, Wd, Li, Wg, Li, Xh, Li, Xl, Li, Xy, Li, Zy, Li, Liang, H, Liang, Yf, Liang, Yt, Liao, Gr, Liao, Lz, Libby, J, Limphirat, A, Lin, Cx, Liu, Bj, Liu, Cx, Liu, D, Liu, Fh, Liu, F, Liu, Hb, Liu, Hm, Liu, Hh, Liu, Jb, Liu, Jl, Liu, Jy, Liu, K, Liu, Ky, Liu, L, Liu, Mh, Liu, Pl, Liu, Q, Liu, Sb, Liu, S, Liu, T, Liu, Wm, Liu, X, Liu, Y, Liu, Yb, Liu, Za, Liu, Zq, Lou, Xc, Fx, Lu, Hj, Lu, Jd, Lu, Jg, Lu, Xl, Lu, Lu, Y, Yp, Lu, Luo, Cl, Luo, Mx, Luo, T, Luo, Xl, Lyu, Xr, Fc, Ma, Hl, Ma, Ll, Ma, Mm, Ma, Qm, Ma, Rq, Ma, Rt, Ma, Xx, Ma, Xy, Ma, Ma, Y, Maas, Fe, Maggiora, M, Maldaner, S, Malde, S, Malik, Qa, Mangoni, A, Mao, Yj, Mao, Zp, Marcello, S, Meng, Zx, Messchendorp, Jg, Mezzadri, G, Min, Tj, Mitchell, Re, Xh, Mo, Muchnoi, Ny, Muramatsu, H, Nakhoul, S, Nefedov, Y, Nerling, F, Nikolaev, Ib, Ning, Z, Nisar, S, Olsen, Sl, Ouyang, Q, Pacetti, S, Pan, X, Pan, Y, Pathak, A, Patteri, P, Pelizaeus, M, Peng, Hp, Peters, K, Pettersson, J, Ping, Jl, Ping, Rg, Pogodin, S, Poling, R, Prasad, V, Qi, H, Hr, Qi, Kh, Qi, Qi, M, Ty, Qi, Qian, S, Qian, Wb, Qian, Z, Qiao, Cf, Qin, Lq, Qin, Xp, Qin, Xs, Qin, Zh, Qiu, Jf, Sq, Qu, Rashid, Kh, Ravindran, K, Redmer, Cf, Rivetti, A, Rodin, V, Rolo, M, Rong, G, Rosner, C, Rump, M, Sang, Hs, Sarantsev, A, Schelhaas, Y, Schnier, C, Schoenning, K, Scodeggio, M, Shan, Dc, Shan, W, Shan, Xy, Shangguan, Jf, Shao, M, Shen, Cp, Shen, Hf, Shen, Px, Shen, Xy, Shi, Hc, Shi, Rs, Shi, X, Shi, Xd, Song, Wm, Song, Yx, Sosio, S, Spataro, S, Kx, Su, Pp, Su, Sun, Gx, Sun, Hk, Sun, Jf, Sun, L, Sun, Ss, Sun, T, Sun, Wy, Sun, X, Sun, Yj, Sun, Yk, Sun, Yz, Sun, Zt, Tan, Yh, Tan, Yx, Tang, Cj, Tang, Gy, Tang, J, Teng, Jx, Thoren, V, Tian, Wh, Tian, Y, Uman, I, Wang, B, Wang, Bl, Wang, Cw, Wang, Dy, Wang, Hj, Wang, Hp, Wang, K, Wang, Ll, Wang, M, Wang, Mz, Wang, S, Wang, Tj, Wang, W, Wang, Wh, Wang, Wp, Wang, X, Wang, Xf, Wang, Xl, Wang, Y, Wang, Yd, Wang, Yf, Wang, Yq, Wang, Z, Wang, Zy, Wei, Dh, Weidner, F, Wen, Sp, White, Dj, Wiedner, U, Wilkinson, G, Wolke, M, Wollenberg, L, Jf, Wu, Lh, Wu, Lj, Wu, Wu, X, Wu, Z, Xia, L, Xiang, T, Xiao, H, Xiao, Sy, Xiao, Zj, Xie, Xh, Xie, Y, Xie, Yg, Xie, Yh, Xing, Ty, Cj, Xu, Gf, Xu, Qj, Xu, Xu, W, Xp, Xu, Yc, Xu, Yan, F, Yan, L, Yan, Wb, Yan, Wc, Yan, X, Yang, Hj, Yang, Hx, Yang, L, Yang, Sl, Yang, Yf, Yang, Z, Ye, M, Mh, Ye, Yin, Jh, You, Zy, Bx, Yu, Cx, Yu, Yu, G, Js, Yu, Yu, T, Yuan, Cz, Yuan, L, Yuan, Xq, Yuan, Y, Yuan, Zy, Yue, Cx, Zafar, Aa, Zeng, Xz, Zeng, Y, Zhang, Aq, Zhang, Bx, Zhang, Gy, Zhang, H, Zhang, Hh, Zhang, Hy, Zhang, Jl, Zhang, Jq, Zhang, Jw, Zhang, Jy, Zhang, Jz, Zhang, Lm, Zhang, Lq, Zhang, L, Zhang, Sf, Zhang, Sl, Zhang, Xd, Zhang, Xy, Zhang, Y, Zhang, Yt, Zhang, Yh, Zhang, Zy, Zhao, G, Zhao, J, Zhao, Jy, Zhao, Jz, Zhao, L, Zhao, Mg, Zhao, Q, Zhao, Sj, Zhao, Yb, Zhao, Yx, Zhao, Zg, Zhemchugov, A, Zheng, B, Zheng, Jp, Zheng, Yh, Zhong, B, Zhong, C, Zhou, H, Zhou, Lp, Zhou, Q, Zhou, X, Zhou, Xk, Zhou, Xr, Zhou, Xy, Zhu, An, Zhu, J, Zhu, K, Zhu, Kj, Zhu, Sh, Zhu, Tj, Zhu, Wj, Zhu, Yc, Zhu, Za, Zou, Bs, and Zou, Jh
Published: 2022

16. Identification of potential core genes in triple negative breast cancer using bioinformatics analysis

Author: Li MX, Jin LT, Wang TJ, Feng YJ, Pan CP, Zhao DM, and Shao J
Subjects: hub genes, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, TNBC, lcsh:RC254-282, expression profiling data
Abstract: Man-Xiu Li, Li-Ting Jin, Tie-Jun Wang, Yao-Jun Feng, Cui-Ping Pan, Dei-Mian Zhao, Jun Shao Department of Breast Cancer, Hubei Cancer Hospital, Wuhan, People’s Republic of China Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor clinical outcome and limited treatment options. Lacking molecular targets, chemotherapy is the main adjuvant treatment for TNBC patients. Materials and methods: To explore potential therapeutic targets for TNBC, we analyzed three microarray datasets (GSE38959, GSE45827, and GSE65194) derived from the Gene Expression Omnibus (GEO) database. The GEO2R tool was used to screen out differentially expressed genes (DEGs) between TNBC and normal tissue. Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed using the Database for Annotation, Visualization and Integrated Discovery to identify the pathways and functional annotation of DEGs. Protein–protein interaction of these DEGs was analyzed based on the Search Tool for the Retrieval of Interacting Genes database and visualized by Cytoscape software. In addition, we used the online Kaplan–Meier plotter survival analysis tool to evaluate the prognostic value of hub genes expression in breast cancer patients. Results: A total of 278 upregulated DEGs and 173 downregulated DEGs were identified. Among them, ten hub genes with a high degree of connectivity were picked out. Overexpression of these hub genes was associated with unfavorable prognosis of breast cancer, especially, CCNB1 overexpression was observed and indicated poor outcome of TNBC. Conclusion: Our study suggests that CCNB1 was overexpressed in TNBC compared with normal breast tissue, and overexpression of CCNB1 was an unfavorable prognostic factor of TNBC patients. Further study is needed to explore the value of CCNB1 in the treatment of TNBC. Keywords: triple-negative breast cancer, hub genes, expression profiling data, CCNB1
Published: 2018

17. CHANGHAI ADVANCED ENDOSCOPY COURSES FOR ERCP TRAINING PROGRAM (CHANCE): A SHORT-TERM TRAINING MODEL IN CHINA

Author: Zhang, D, additional, Wang, D, additional, Wang, TJ, additional, Xin, L, additional, Li, ZS, additional, and Hu, LH, additional
Published: 2020
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18. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Author: Wain, Louise V., Verwoert, Germaine C., O'Reilly, Paul F., Shi, Gang, Johnson, Toby, Johnson, Andrew D., Bochud, Murielle, Rice, Kenneth M., Henneman, Peter, Smith, Albert V., Ehret, Georg B., Amin, Najaf, Larson, Martin G., Mooser, Vincent, Hadley, David, Dörr, Marcus, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile J. W., Zhao, Jing Hua, Heath, Simon, Laan, Maris, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'An, Arora, Pankaj, Lucas, Gavin, Pirastu, Nicola, Pichler, Irene, Jackson, Anne U., Webster, Rebecca J., Zhang, Feng, Peden, John F., Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I., Trompet, Stella, Bragg-Gresham, Jennifer L., Alizadeh, Behrooz Z., Chambers, John C., Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M., Polašek, Ozren, Boban, Mladen, Nelson, Christopher P., Morrison, Alanna C., Pihur, Vasyl, Ganesh, Santhi K., Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco U. S., Rivadeneira, Fernando, Sijbrands, Eric J. G., Uitterlinden, Andre G., Hwang, Shih-Jen, Vasan, Ramachandran S., Wang, Thomas J., Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, McArdle, Wendy L., Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Glazer, Nicole L., Taylor, Kent D., Harris, Tamara B., Alavere, Helene, Haller, Toomas, Keis, Aime, Tammesoo, Mari-Liis, Aulchenko, Yurii, Barroso, In S., Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M., Penninx, Brenda W., Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco M, Fabiola, Facheris, Maurizio, Collins, Francis S., Bergman, Richard N., Beilby, John P., Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Anders, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S., Navarro, Pau, Wild, Sarah H., Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco J. C., Willemsen, Gonneke, Parker, Alex N., Rose, Lynda M., Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, Van Der Klauw, Melanie M., Zhang, Weihua, Li, Xinzhong, Scott, James, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thomas, Davies, Gail, Starr, John M., Emilsson, Valur, Plump, Andrew, Lindeman, Jan H., Hoen, Peter A. C. T., König, Inke R., Felix, Janine F., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L., Fornage, Myriam, Mitchell, Gary F., Smith, Nicholas L., Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Samani, Nilesh J., Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J., Wichmann, H-Erich, Raitakari, Olli T., Palmas, Walter, Kooner, Jaspal S., Stolk, Ronald P., Jukema, J Wouter, Wright, Alan F., Boomsma, Dorret I., Bandinelli, Stefania, Gyllensten, Ulf B., Wilson, James F., Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D., Palmer, Lyle J., Tuomilehto, Jaakko, Pfeufer, Arne, Gasparini, Paolo, Siscovick, David, Altshuler, David, Loos, Ruth J. F., Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J., Oostra, Ben A., Metspalu, Andres, Launer, Lenore, Rettig, Rainer, Strachan, David P., Beckmann, Jacques S., Witteman, Jacqueline C. M., Erdmann, Jeanette, Van Dijk, Ko Willems, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M., Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R., Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B., Psaty, Bruce M., Caulfield, Mark J., Rao, Dabeeru C., Tobin, Martin D., Elliott, Paul, Van Duijn, Cornelia M. 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Demissie S, Glazer NL, Loehr LR, Rosamond WD, Bis JC, Folsom AR, Benjamin E, Aulchenko YS, Haritunians T, Couper D, Murabito J, Yang YA, Stricker BH, Gottdiener JS, Chang PP, Wang TJ, Rice KM, Heckbert SR, Fox ER, Willerson JT, Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Gao X, Yang Q, O'Connell JR, Schmidt H, Ketkar S, Hwang SJ, Teumer A, Paré G, Atkinson EJ, Lohman K, Cornelis MC, Probst-Hensch NM, Kronenberg F, Tönjes A, Hayward C, Rampersaud E, Mitchell BD, Arking DE, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer IH, Siscovick D, Zillikens MC, Feitosa M, Province M, de Andrade M, Turner ST, Wild PS, Schnabel RB, Wilde S, Munzel TF, Leak TS, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu FB, Johansson A, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Imboden M, Nitsch D, Brandstätter A, Kollerits B, Kedenko L, Mägi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Völzke H, Kroemer HK, Nauck M, Völker U, Polasek O, Vitart V, Badola S, Parker AN, Ridker PM, Kardia SL, Curhan GC, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Coresh J, Schmidt R, Shlipak MG, Borecki I, Krämer BK, Rudan I, Gyllensten U, Wilson JF, Pramstaller PP, Rettig R, Hastie N, Chasman DI, Kao WH, Heid IM, Fox CS, Felix SB, Watzinger N, Homuth G, Aragam J, Dörr M, Zweiker R, Lind L, Rodeheffer RJ, Greiser KH, Deckers JW, Stritzke J, Lackner KJ, Ingelsson E, Kullo I, Haerting J, Reffelmann T, Redfield MM, Werdan K, Arnett DK, Blettner M, Friedrich N, Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJ, Beckmann J, Bilo HJ, Bochud M, Brown MJ, Caulfield MJ, Connell JM, Cook HT, Cotlarciuc I, Davey Smith G, de Silva R, Deng G, Devuyst O, Dikkeschei LD, Dimkovic N, Dockrell M, Dominiczak A, Ebrahim S, Eggermann T, Farrall M, Floege J, Forouhi NG, Gansevoort RT, Han X, Hedblad B, Homan van der Heide JJ, Hepkema BG, Hernandez-Fuentes M, Hypponen E, Johnson T, de Jong PE, Kleefstra N, Lagou V, Lapsley M, Li Y, Loos RJ, Luan J, Luttropp K, Maréchal C, Munroe PB, Nordfors L, Penninx BW, Perucha E, Pouta A, Roderick PJ, Ruokonen A, Schalling M, Schlessinger D, Schlieper G, Seelen MA, Sjögren M, Smit JH, Snieder H, Soranzo N, Spector TD, Stenvinkel P, Sternberg MJ, Swaminathan R, Ubink-Veltmaat LJ, Vollenweider P, Waterworth D, Zerres K, Waeber G, Wareham NJ, Maxwell PH, McCarthy MI, Jarvelin MR, Lightstone L, Scott J, Navis G, Elliott P, Kooner JS., Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Life Course Epidemiology (LCE), Lifestyle Medicine (LM), Center for Liver, Digestive and Metabolic Diseases (CLDM), University of Leicester, Department of Genetics [Leicester], Erasmus University Rotterdam, Netherlands Genomics Initiative, Department of Epidemiology and Biostatistics, School of Public Health, Zahedan University of Medical Sciences, Washington University in Saint Louis (WUSTL), Queen Mary University of London (QMUL), National Heart, Lung and Blood Institute, Partenaires INRAE, Centre Hospitalier Universitaire Vaudois (CHUV), Université de Lausanne = University of Lausanne (UNIL), Department of Biostatistics [Oslo], Institute of Basic Medical Sciences [Oslo], Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Medicine [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Leiden University Medical Center (LUMC), Universiteit Leiden, Icelandic Heart Association, Heart Preventive Clinic and Research Institute, University of Iceland [Reykjavik], Johns Hopkins University, School of Medicine, Hôpitaux Universitaires de Genève (HUG), Department of Epidemiology, The Netherlands Cancer Institute, Department of Mathematics, Boston University [Boston] (BU), GlaxoSmithKline, Division of Community Health Sciences, St. George's, University of South Florida [Tampa] (USF), Universität Greifswald - University of Greifswald, University of Washington [Seattle], University of Tartu, Institute of Molecular and Cell Biology, Medical Research Council, Institut de Génomique, Centre National de Génotypage, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University Medical Center Groningen, Department of Genetics, University Medical Center Groningen [Groningen] (UMCG), Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Massachusetts General Hospital [Boston], Centro de Regulación Genómica (CRG), Universitat Pompeu Fabra [Barcelona] (UPF), Università degli studi di Trieste = University of Trieste, Universität zu Lübeck = University of Lübeck [Lübeck], Department of Biostatistics, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, The University of Western Australia (UWA), Department of Twin Research and Genetic Epidemiology, King's College London, London, University of Oxford, Medical University Graz, National Institute on Aging, Centre for population Health Sciences, University of Edinburgh, Uppsala University, Vrije Universiteit Amsterdam [Amsterdam] (VU), Western General Hospital, Harvard Medical School [Boston] (HMS), Brigham and Women's Hospital [Boston], University of Michigan System, University of Groningen, Ealing Hospital, School of Public Health - Department of Epidemiology and Biostatistics, Imperial College London, Medical Genetics Institute, Cedars-Sinai Medical Center, University of Tampere, German Research Center for Environmental Health - Helmholtz Center München (GmbH), Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Split, The University of Texas Health Science Center at Houston (UTHealth), Johns Hopkins University (JHU), Netherlands Consortium for Healthy Aging [Leiden, Netherlands] (NCHA), National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), Swiss Institute of Bioinformatics [Lausanne] (SIB), Finnish Institute of Occupational Health, National Institute of Health and Welfare, University of Oulu, Lapland Central Hospital, University of Bristol [Bristol], Institute for Community Medicine, Unité de Recherche en Epidémiologie Nutritionnelle (UREN), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), US National Institutes of Health, National Heart, Lung, and Blood Institute, European, Epidemiology, Internal Medicine, Public Health, Clinical Genetics, Université de Lausanne (UNIL), LeidenUniversity Medical Centre, University of Iceland, Università degli studi di Trieste, Universität zu Lübeck [Lübeck], University of Western Australia, University of Oxford [Oxford], VU University Amsterdam, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Cité (USPC)-Université Paris 13 (UP13)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National de la Recherche Agronomique (INRA), Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Human genetics, Psychiatry, EMGO - Mental health, NCA - Anxiety & Depression, Epidemiology and Data Science, Medical Research Council (MRC), Louise V., Wain, Germaine C., Verwoert, Paul F., O'Reilly, Gang, Shi, Toby, Johnson, Andrew D., Johnson, Murielle, Bochud, Kenneth M., Rice, Peter, Henneman, Albert V., Smith, Georg B., Ehret, Najaf, Amin, Martin G., Larson, Vincent, Mooser, David, Hadley, Marcus, Dörr, Joshua C., Bi, Thor, Aspelund, Tõnu, Esko, A. Cecile J. W., Janssen, Jing Hua, Zhao, Simon, Heath, Maris, Laan, Jingyuan, Fu, Giorgio, Pisti, Jian'An, Luan, Pankaj, Arora, Gavin, Luca, Pirastu, Nicola, Irene, Pichler, Anne U., Jackson, Rebecca J., Webster, Feng, Zhang, John F., Peden, Helena, Schmidt, Toshiko, Tanaka, Harry, Campbell, Wilmar, Igl, Yuri, Milaneschi, Jouke Jan, Hottenga, Veronique, Vitart, Daniel I., Chasman, Stella, Trompet, Jennifer L., Bragg Gresham, Behrooz Z., Alizadeh, John C., Chamber, Xiuqing, Guo, Terho, Lehtimäki, Brigitte, Kühnel, Lorna M., Lopez, Ozren, Polašek, Mladen, Boban, Christopher P., Nelson, Alanna C., Morrison, Vasyl, Pihur, Santhi K., Ganesh, Albert, Hofman, Suman, Kundu, Francesco U. S., Mattace Raso, Fernando, Rivadeneira, Eric J. G., Sijbrand, Andre G., Uitterlinden, Shih Jen, Hwang, Ramachandran S., Vasan, Thomas J., Wang, Sven, Bergmann, Peter, Vollenweider, Gérard, Waeber, Jaana, Laitinen, Anneli, Pouta, Paavo, Zitting, Wendy L., Mcardle, Heyo K., Kroemer, Uwe, Völker, Henry, Völzke, Nicole L., Glazer, Kent D., Taylor, Tamara B., Harri, Helene, Alavere, Toomas, Haller, Aime, Kei, Mari Liis, Tammesoo, Yurii, Aulchenko, Inês, Barroso, Kay Tee, Khaw, Pilar, Galan, Serge, Hercberg, Mark, Lathrop, Susana, Eyheramendy, Elin, Org, Siim, Sõber, Xiaowen, Lu, Ilja M., Nolte, Brenda W., Penninx, Tanguy, Corre, Corrado, Masciullo, Cinzia, Sala, Leif, Groop, Benjamin F., Voight, Olle, Melander, Christopher J., O'Donnell, Veikko, Salomaa, D'Adamo, ADAMO PIO, Antonella, Fabretto, Flavio, Faletra, Sheila, Ulivi, Fabiola Del Greco, M, Maurizio, Facheri, Francis S., Collin, Richard N., Bergman, John P., Beilby, Joseph, Hung, A., William Musk, Massimo, Mangino, So Youn, Shin, Nicole, Soranzo, Hugh, Watkin, Anuj, Goel, Anders, Hamsten, Pierre, Gider, Marisa, Loitfelder, Marion, Zeginigg, Dena, Hernandez, Samer S., Najjar, Pau, Navarro, Sarah H., Wild, Anna Maria, Corsi, Andrew, Singleton, Eco J. C., de Geu, Gonneke, Willemsen, Alex N., Parker, Lynda M., Rose, Brendan, Buckley, David, Stott, Marco, Orru, Manuela, Uda, Melanie M., van der Klauw, Weihua, Zhang, Xinzhong, Li, James, Scott, Yii Der Ida, Chen, Gregory L., Burke, Mika, Kähönen, Jorma, Viikari, Angela, Döring, Thomas, Meitinger, Gail, Davie, John M., Starr, Valur, Emilsson, Andrew, Plump, Jan H., Lindeman, Peter A. C., 't Hoen, Inke R., König, Janine F., Felix, Robert, Clarke, Jemma C., Hopewell, Halit, Ongen, Monique, Breteler, Stéphanie, Debette, Anita L., Destefano, Myriam, Fornage, Gary F., Mitchell, Nicholas L., Smith, Hilma, Holm, Kari, Stefansson, Gudmar, Thorleifsson, Unnur, Thorsteinsdottir, Nilesh J., Samani, Michael, Preu, Igor, Rudan, Caroline, Hayward, Ian J., Deary, H., Erich Wichmann, Olli T., Raitakari, Walter, Palma, Jaspal S., Kooner, Ronald P., Stolk, J., Wouter Jukema, Alan F., Wright, Dorret I., Boomsma, Stefania, Bandinelli, Ulf B., Gyllensten, James F., Wilson, Luigi, Ferrucci, Reinhold, Schmidt, Martin, Farrall, Tim D., Spector, Lyle J., Palmer, Jaakko, Tuomilehto, Arne, Pfeufer, Gasparini, Paolo, David, Siscovick, David, Altshuler, Ruth J. F., Loo, Daniela, Toniolo, Harold, Snieder, Christian, Gieger, Pierre, Meneton, Nicholas J., Wareham, Ben A., Oostra, Andres, Metspalu, Lenore, Launer, Rainer, Rettig, David P., Strachan, Jacques S., Beckmann, Jacqueline C. M., Witteman, Jeanette, Erdmann, Ko Willems van, Dijk, Eric, Boerwinkle, Michael, Boehnke, Paul M., Ridker, Marjo Riitta, Jarvelin, Aravinda, Chakravarti, Goncalo R., Abecasi, Vilmundur, Gudnason, Christopher Newton, Cheh, Daniel, Levy, Patricia B., Munroe, Bruce M., Psaty, Mark J., Caulfield, Dabeeru C., Rao, Martin D., Tobin, Paul, Elliott, Cornelia M., van Duijn, Biological Psychology, Neuroscience Campus Amsterdam - Anxiety & Depression, EMGO+ - Mental Health, Wain, Louise V., Verwoert, Germaine C., O'Reilly, Paul F., Shi, Gang, Johnson, Toby, Johnson, Andrew D., Bochud, Murielle, Rice, Kenneth M., Henneman, Peter, Smith, Albert V., Ehret, Georg B., Amin, Najaf, Larson, Martin G., Mooser, Vincent, Hadley, David, Dörr, Marcu, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile J. W., Zhao, Jing Hua, Heath, Simon, Laan, Mari, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'An, Arora, Pankaj, Lucas, Gavin, Pichler, Irene, Jackson, Anne U., Webster, Rebecca J., Zhang, Feng, Peden, John F., Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I., Trompet, Stella, Bragg-Gresham, Jennifer L., Alizadeh, Behrooz Z., Chambers, John C., Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M., Polašek, Ozren, Boban, Mladen, Nelson, Christopher P., Morrison, Alanna C., Pihur, Vasyl, Ganesh, Santhi K., Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco U. S., Rivadeneira, Fernando, Sijbrands, Eric J. G., Uitterlinden, Andre G., Hwang, Shih-Jen, Vasan, Ramachandran S., Wang, Thomas J., Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, Mcardle, Wendy L., Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Glazer, Nicole L., Taylor, Kent D., Harris, Tamara B., Alavere, Helene, Haller, Tooma, Keis, Aime, Tammesoo, Mari-Lii, Aulchenko, Yurii, Barroso, In S., Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M., Penninx, Brenda W., Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco M, Fabiola, Facheris, Maurizio, Collins, Francis S., Bergman, Richard N., Beilby, John P., Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Ander, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S., Navarro, Pau, Wild, Sarah H., Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco J. C., Willemsen, Gonneke, Parker, Alex N., Rose, Lynda M., Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, Van Der Klauw, Melanie M., Zhang, Weihua, Li, Xinzhong, Scott, Jame, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thoma, Davies, Gail, Starr, John M., Emilsson, Valur, Plump, Andrew, Lindeman, Jan H., Hoen, Peter A. C. T., König, Inke R., Felix, Janine F., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L., Fornage, Myriam, Mitchell, Gary F., Smith, Nicholas L., Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Samani, Nilesh J., Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J., Wichmann, H-Erich, Raitakari, Olli T., Palmas, Walter, Kooner, Jaspal S., Stolk, Ronald P., Jukema, J Wouter, Wright, Alan F., Boomsma, Dorret I., Bandinelli, Stefania, Gyllensten, Ulf B., Wilson, James F., Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D., Palmer, Lyle J., Tuomilehto, Jaakko, Pfeufer, Arne, Siscovick, David, Altshuler, David, Loos, Ruth J. F., Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J., Oostra, Ben A., Metspalu, Andre, Launer, Lenore, Rettig, Rainer, Strachan, David P., Beckmann, Jacques S., Witteman, Jacqueline C. M., Erdmann, Jeanette, Van Dijk, Ko Willem, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M., Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R., Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B., Psaty, Bruce M., Caulfield, Mark J., Rao, Dabeeru C., Tobin, Martin D., Elliott, Paul, Van, Duijn, Cornelia M., McEniery CM, Wilkinson, Ib, Cockcroft, Jr, O'Shaughnessy, Km, Newhouse, Sj, Yasmin, Smith, Av, Eiriksdottir, G, Launer, Lj, Sigurdsson, S, Aspelund, T, Gudnason, V, De Bacquer, D, Rietzschel, Er, De Backer, Gg, Van Bortel, L, De Buyzere, Ml, Segers, P, Bekaert, S, Gillebert, Tc, De Meyer, T, Ferrucci, L, Tanaka, T, Johnson, Ad, Levy, D, Benjamin, Ej, Mitchell, Gf, Vita, Ja, Larson, Mg, Hamburg, Nm, Vasan, R, Isaacs, A, Schut, Af, Oostra, Ba, van Duijn, Cm, van Rijn, Mj, Sie, Mp, Newman, Ab, Herrington, Dm, Andrews, J, Ding, J, Sutton-Tyrrell, Kc, Harris, Tb, Howard, Td, Liu, Y, Parsa, A, Shuldiner, Ar, Mcardle, Pf, Gibson, Q, Post, W, Dehghan, A, Hofman, A, Uitterlinden, Ag, Sijbrands, Ej, Rivadeneira, F, Mattace-Raso, Fu, Verwoert, Gc, Witteman, Jc, Scuteri, A, Lakatta, Eg, Jewell, E, Abecasis, Gr, Tarasov, Kv, Uda, M, Najjar, S, Sanna, S, Attwood, T, Belz, S, Braund, P, Cambien, F, Cooper, J, Crisp-Hihn, A, Deloukas, P, Foad, N, Eardman, J, Goodall, Ah, Gracey, J, Gray, E, Gulde, S, Gwilliams, R, Heimerl, S, Hengstenberg, C, Jolley, J, Krishnan, U, Linsel-Nitschke, P, Lloyd-Jones, H, Lugauer, I, Lundmark, P, Maouche, S, Moore, J, Muir, D, Murray, E, Nelson, Cp, Neudert, J, Niblett, D, O'Leary, K, Ouwehand, Wh, Pollard, H, Rankin, A, Rice, Cm, Sager, H, Samani, Nj, Sambrook, J, Schmitz, G, Scholz, M, Schroeder, L, Schunkert, H, Syvannen, Ac, Wallace, C, Kathiresan, S, Reilly, Mp, Erdmann, J, Assimes, Tl, Boerwinkle, E, Hall, A, König, Ir, Laaksonen, R, Mcpherson, R, Thompson, Jr, Thorsteinsdottir, U, Ziegler, A, Absher, D, Chen, L, Cupples, La, Halperin, E, Li, M, Musunuru, K, Preuss, M, Schillert, A, Thorleifsson, G, Voight, Bf, Wells, Ga, Assime, Tl, Holm, H, Roberts, R, Stewart, Af, Fortmann, S, Go, A, Hlatky, M, Iribarren, C, Knowles, J, Myers, R, Quertermous, T, Sidney, S, Risch, N, Tang, H, Blankenberg, S, Zeller, T, Wild, P, Schnabel, R, Sinning, C, Lackner, K, Tiret, L, Nicaud, V, Bickel, C, Rupprecht, Hj, Perret, C, Proust, C, Münzel, T, Barbalic, M, Bis, J, Chen, Iy, Cupples, L, Demissie-Banjaw, S, Folsom, A, Glazer, N, Harris, T, Heckbert, S, Lumley, T, Marciante, K, Morrison, A, O' Donnell, Cj, Psaty, Bm, Rice, K, Rotter, Ji, Siscovick, D, Smith, N, Smith, A, Taylor, Kd, van Duijn, C, Volcik, K, Whitteman, J, Ramachandran, V, Uitterlinden, A, Gretarsdottir, S, Gulcher, Jr, Kong, A, Stefansson, K, Thorgeirsson, G, Andersen, K, Fischer, M, Grosshennig, A, Lieb, W, Stark, K, Schreiber, S, Wichmann, He, Aherrahrou, Z, Bruse, P, Doering, A, Illig, T, Klopp, N, Loley, C, Medack, A, Meisinger, C, Meitinger, T, Nahrstedt, J, Peters, A, Wagner, Ak, Willenborg, C, Böhm, Bo, Dobnig, H, Grammer, Tb, Hoffmann, Mm, Kleber, M, März, W, Meinitzer, A, Winkelmann, Br, Pilz, S, Renner, W, Scharnagl, H, Stojakovic, T, Tomaschitz, A, Winkler, K, Guiducci, C, Burtt, N, Gabriel, Sb, O'Donnell, Cj, Elosua, R, Peltonen, L, Salomaa, V, Schwartz, Sm, Melander, O, Altshuler, D, Dandona, S, Jarinova, O, Qu, L, Wilensky, R, Matthai, W, Hakonarson, Hh, Devaney, J, Burnett, M, Pichard, Ad, Kent, Km, Satler, L, Lindsay, Jm, Waksman, R, Knouff, Cw, Waterworth, Dm, Walker, Mc, Mooser, V, Epstein, Se, Rader, Dj, Wright, Bj, Balmforth, Aj, Ball, Sg, Smith, Nl, Felix, Jf, Morrison, Ac, Demissie, S, Glazer, Nl, Loehr, Lr, Rosamond, Wd, Bis, Jc, Folsom, Ar, Benjamin, E, Aulchenko, Y, Haritunians, T, Couper, D, Murabito, J, Yang, Ya, Stricker, Bh, Gottdiener, J, Chang, Pp, Wang, Tj, Rice, Km, Heckbert, Sr, Fox, Er, Willerson, Jt, Köttgen, A, Pattaro, C, Böger, Ca, Fuchsberger, C, Olden, M, Gao, X, Yang, Q, O'Connell, Jr, Schmidt, H, Ketkar, S, Hwang, Sj, Teumer, A, Paré, G, Atkinson, Ej, Lohman, K, Cornelis, Mc, Probst-Hensch, Nm, Kronenberg, F, Tönjes, A, Hayward, C, Rampersaud, E, Mitchell, Bd, Arking, De, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, de Boer, Ih, Zillikens, Mc, Feitosa, M, Province, M, de Andrade, M, Turner, St, Schnabel, Rb, Wilde, S, Munzel, Tf, Leak, T, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, Fb, Johansson, A, Igl, W, Zaboli, G, Wild, Sh, Wright, Af, Campbell, H, Ellinghaus, D, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, Hk, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, An, Ridker, Pm, Kardia, Sl, Curhan, Gc, Franke, A, Rochat, T, Paulweber, B, Prokopenko, I, Wang, W, Coresh, J, Schmidt, R, Shlipak, Mg, Borecki, I, Krämer, Bk, Rudan, I, Gyllensten, U, Wilson, Jf, Pramstaller, Pp, Rettig, R, Hastie, N, Chasman, Di, Kao, Wh, Heid, Im, Fox, C, Felix, Sb, Watzinger, N, Homuth, G, Aragam, J, Dörr, M, Zweiker, R, Lind, L, Rodeheffer, Rj, Greiser, Kh, Deckers, Jw, Stritzke, J, Lackner, Kj, Ingelsson, E, Kullo, I, Haerting, J, Reffelmann, T, Redfield, Mm, Werdan, K, Arnett, Dk, Blettner, M, Friedrich, N, Chambers, Jc, Zhang, W, Lord, Gm, van der Harst, P, Lawlor, Da, Sehmi, J, Gale, Dp, Wass, Mn, Ahmadi, Kr, Bakker, Sj, Beckmann, J, Bilo, Hj, Bochud, M, Brown, Mj, Caulfield, Mj, Connell, Jm, Cook, Ht, Cotlarciuc, I, Davey Smith, G, de Silva, R, Deng, G, Devuyst, O, Dikkeschei, Ld, Dimkovic, N, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Floege, J, Forouhi, Ng, Gansevoort, Rt, Han, X, Hedblad, B, Homan van der Heide, Jj, Hepkema, Bg, Hernandez-Fuentes, M, Hypponen, E, Johnson, T, de Jong, Pe, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, Rj, Luan, J, Luttropp, K, Maréchal, C, Munroe, Pb, Nordfors, L, Penninx, Bw, Perucha, E, Pouta, A, Roderick, Pj, Ruokonen, A, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, Ma, Sjögren, M, Smit, Jh, Snieder, H, Soranzo, N, Spector, Td, Stenvinkel, P, Sternberg, Mj, Swaminathan, R, Ubink-Veltmaat, Lj, Vollenweider, P, Waterworth, D, Zerres, K, Waeber, G, Wareham, Nj, Maxwell, Ph, Mccarthy, Mi, Jarvelin, Mr, Lightstone, L, Scott, J, Navis, G, Elliott, P, and Kooner, Js.
Subjects: Netherlands Twin Register (NTR), Linkage disequilibrium, pulse pressure, mean arterial pressure, genome-wide, [SDV]Life Sciences [q-bio], Genome-wide association study, BLOOD-PRESSURE, Blood Pressure, 030204 cardiovascular system & hematology, Linkage Disequilibrium, 0302 clinical medicine, RELEVANCE, CardioGram, Medicine and Health Sciences, Genetics & Heredity, ddc:616, Genetics, 0303 health sciences, Genome-wide association, 11 Medical And Health Sciences, Arteries, ADRENERGIC-RECEPTOR TRAFFICKING, Pulse pressure, EchoGen consortium, Hypertension, HEART-FAILURE, arterial pressure, Case-Control Studie, Life Sciences & Biomedicine, Human, circulatory and respiratory physiology, medicine.medical_specialty, Mean arterial pressure, Arterie, AortaGen Consortium, Cardiogenics consortium, Locus (genetics), Biology, Polymorphism, Single Nucleotide, Article, Follow-Up Studie, 03 medical and health sciences, Internal medicine, medicine, Humans, cardiovascular diseases, METAANALYSIS, 030304 developmental biology, Genetic association, Science & Technology, HYPERTENSION, MORTALITY, Case-control study, CARDIOVASCULAR-DISEASE RISK, 06 Biological Sciences, GENE, MICE, Endocrinology, Blood pressure, CKDGen consortium, Genetic Loci, Case-Control Studies, KidneyGen consortium, CHARGE Consortium Heart Failure Working Group, LifeLines Cohort Study, Developmental Biology, Follow-Up Studies, Genome-Wide Association Study
Abstract: Les affiliations des 100 premiers auteurs sont renseignées dans la notice. Les affiliations des autres auteurs sont disponibles à la fin de la publication.; International audience; Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
Published: 2016

19. A meta-analysis of genome-wide association studies of growth differentiation factor-15 concentration in blood

Author: Jiang, J, Thalamuthu, A, Ho, JE, Mahajan, A, Ek, WE, Brown, DA, Breit, SN, Wang, TJ, Gyllensten, U, Chen, MH, Enroth, S, Januzzi, JL, Lind, L, Armstrong, NJ, Kwok, JB, Schofield, PR, Wen, W, Trollor, JN, Johansson, Å, Morris, AP, Vasan, RS, Sachdev, PS, Mather, KA, Jiang, J, Thalamuthu, A, Ho, JE, Mahajan, A, Ek, WE, Brown, DA, Breit, SN, Wang, TJ, Gyllensten, U, Chen, MH, Enroth, S, Januzzi, JL, Lind, L, Armstrong, NJ, Kwok, JB, Schofield, PR, Wen, W, Trollor, JN, Johansson, Å, Morris, AP, Vasan, RS, Sachdev, PS, and Mather, KA
Abstract: Blood levels of growth differentiation factor-15 (GDF-15), also known as macrophage inhibitory cytokine-1 (MIC-1), have been associated with various pathological processes and diseases, including cardiovascular disease and cancer. Prior studies suggest genetic factors play a role in regulating blood MIC-1/GDF-15 concentration. In the current study, we conducted the largest genome-wide association study (GWAS) to date using a sample of ~5,400 community-based Caucasian participants, to determine the genetic variants associated with MIC-1/GDF-15 blood concentration. Conditional and joint (COJO), gene-based association, and gene-set enrichment analyses were also carried out to identify novel loci, genes, and pathways. Consistent with prior results, a locus on chromosome 19, which includes nine single nucleotide polymorphisms (SNPs) (top SNP, rs888663, p = 1.690 × 10-35), was significantly associated with blood MIC-1/GDF-15 concentration, and explained 21.47% of its variance. COJO analysis showed evidence for two independent signals within this locus. Gene-based analysis confirmed the chromosome 19 locus association and in addition, a putative locus on chromosome 1. Gene-set enrichment analyses showed that the"COPI-mediated anterograde transport" gene-set was associated with MIC-1/GDF15 blood concentration with marginal significance after FDR correction (p = 0.067). In conclusion, a locus on chromosome 19 was associated with MIC-1/GDF-15 blood concentration with genome-wide significance, with evidence for a new locus (chromosome 1). Future studies using independent cohorts are needed to confirm the observed associations especially for the chromosomes 1 locus, and to further investigate and identify the causal SNPs that contribute to MIC-1/GDF-15 levels.
Published: 2018

20. Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

Author: Tynkkynen, J, Chouraki, V, van der Lee, Sven, Hernesniemi, J, Yang, Q, Li, S, Beiser, A, Larson, MG, Saaksjarvi, K, Shipley, MJ, Singh-Manoux, A, Gerszten, RE, Wang, TJ, Havulinna, AS, Wurtz, P, Fischer, K, Demirkan, Ayse, Ikram, Arfan, Amin, Najaf, Lehtimaki, T, Kahonen, M, Perola, M, Metspalu, A, Kangas, AJ, Soininen, P, Ala-Korpela, M, Vasan, RS, Kivimaki, M, Duijn, Cornelia, Seshadri, S, Salomaa, V, Tynkkynen, J, Chouraki, V, van der Lee, Sven, Hernesniemi, J, Yang, Q, Li, S, Beiser, A, Larson, MG, Saaksjarvi, K, Shipley, MJ, Singh-Manoux, A, Gerszten, RE, Wang, TJ, Havulinna, AS, Wurtz, P, Fischer, K, Demirkan, Ayse, Ikram, Arfan, Amin, Najaf, Lehtimaki, T, Kahonen, M, Perola, M, Metspalu, A, Kangas, AJ, Soininen, P, Ala-Korpela, M, Vasan, RS, Kivimaki, M, Duijn, Cornelia, Seshadri, S, and Salomaa, V
Published: 2018

21. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

Author: Jiang, X, O'Reilly, PF, Aschard, H, Hsu, YH, Richards, JB, Dupuis, J, Ingelsson, E, Karasik, D, Pilz, S, Berry, D, Kestenbaum, B, Zheng, JS, Luan, JN, Sofianopoulou, E, Streeten, EA, Albanes, D, Lutsey, PL, Yao, L, Tang, WH, Econs, MJ, Wallaschofski, H, Volzke, H, Zhou, A, Power, C, McCarthy, MI, Michos, ED, Boerwinkle, E, Weinstein, SJ, Freedman, N D, Huang, WY, Schoor, NM, van der Velde, Nathalie, de Groot, LCPGM (Lisette), Enneman, Anke, Cupples, LA, Booth, SL, Vasan, RS, Liu, CT, Zhou, YH, Ripatti, S, Ohlsson, C, Vandenput, L, Lorentzon, M, Eriksson, JG, Shea, MK, Houston, DK, Kritchevsky, SB, Liu, YM, Lohman, KK, Ferrucci, L, Peacock, M, Gieger, C, Beekman, M, Slagboom, E, Deelen, J, van Heemst, D, Kleber, ME, Marz, W, Boer, IH (Ian), Wood, AC, Rotter, JI, Rich, SS, Robinson-Cohen, C, Heijer, Mariska, Jarvelin, MR, Cavadino, A, Joshi, PK, Wilson, JF, Hayward, C, Lind, L, Michaelsson, K, Trompet, S, Zillikens, M.C., Uitterlinden, André, Rivadeneira, Fernando, Broer, Linda, Zgaga, L, Campbell, H, Theodoratou, E, Farrington, SM, Timofeeva, M, Dunlop, MG, Valdes, AM, Tikkanen, E, Lehtimaki, T, Lyytikainen, LP, Kahonen, M, Raitakari, OT, Mikkila, V, Ikram, Arfan, Sattar, N, Jukema, JW, Wareham, NJ, Langenberg, C, Forouhi, NG, Gundersen, TE, Khaw, KT, Butterworth, AS, Danesh, J, Spector, T, Wang, TJ, Hypponen, E, Kraft, P, Kiel, DP, Jiang, X, O'Reilly, PF, Aschard, H, Hsu, YH, Richards, JB, Dupuis, J, Ingelsson, E, Karasik, D, Pilz, S, Berry, D, Kestenbaum, B, Zheng, JS, Luan, JN, Sofianopoulou, E, Streeten, EA, Albanes, D, Lutsey, PL, Yao, L, Tang, WH, Econs, MJ, Wallaschofski, H, Volzke, H, Zhou, A, Power, C, McCarthy, MI, Michos, ED, Boerwinkle, E, Weinstein, SJ, Freedman, N D, Huang, WY, Schoor, NM, van der Velde, Nathalie, de Groot, LCPGM (Lisette), Enneman, Anke, Cupples, LA, Booth, SL, Vasan, RS, Liu, CT, Zhou, YH, Ripatti, S, Ohlsson, C, Vandenput, L, Lorentzon, M, Eriksson, JG, Shea, MK, Houston, DK, Kritchevsky, SB, Liu, YM, Lohman, KK, Ferrucci, L, Peacock, M, Gieger, C, Beekman, M, Slagboom, E, Deelen, J, van Heemst, D, Kleber, ME, Marz, W, Boer, IH (Ian), Wood, AC, Rotter, JI, Rich, SS, Robinson-Cohen, C, Heijer, Mariska, Jarvelin, MR, Cavadino, A, Joshi, PK, Wilson, JF, Hayward, C, Lind, L, Michaelsson, K, Trompet, S, Zillikens, M.C., Uitterlinden, André, Rivadeneira, Fernando, Broer, Linda, Zgaga, L, Campbell, H, Theodoratou, E, Farrington, SM, Timofeeva, M, Dunlop, MG, Valdes, AM, Tikkanen, E, Lehtimaki, T, Lyytikainen, LP, Kahonen, M, Raitakari, OT, Mikkila, V, Ikram, Arfan, Sattar, N, Jukema, JW, Wareham, NJ, Langenberg, C, Forouhi, NG, Gundersen, TE, Khaw, KT, Butterworth, AS, Danesh, J, Spector, T, Wang, TJ, Hypponen, E, Kraft, P, and Kiel, DP
Published: 2018

22. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Author: Ehret, Georg B., Munroe, Patricia B., Rice, Kenneth M., Bochud, Murielle, Johnson, Andrew D., Chasman, Daniel I., Smith, Albert V., Tobin, Martin D., Verwoert, Germaine C., Hwang, Shih-Jen, Pihur, Vasyl, Vollenweider, Peter, O'Reilly, Paul F., Amin, Najaf, Bragg-Gresham, Jennifer L., Teumer, Alexander, Glazer, Nicole L., Launer, Lenore, Zhao, Jing Hua, Aulchenko, Yurii, Heath, Simon, Sober, Siim, Parsa, Afshin, Luan, Jian'an, Arora, Pankaj, Dehghan, Abbas, Zhang, Feng, Lucas, Gavin, Hicks, Andrew A., Jackson, Anne U., Peden, John F., Tanaka, Toshiko, Wild, Sarah H., Rudan, Igor, Igl, Wilmar, Milaneschi, Yuri, Parker, Alex N., Fava, Cristiano, Chambers, John C., Fox, Ervin R., Kumari, Meena, Go, Min Jin, van der Harst, Pim, Kao, Wen Hong Linda, Sjögren, Marketa, Vinay, D. G., Alexander, Myriam, Tabara, Yasuharu, Shaw-Hawkins, Sue, Whincup, Peter H., Liu, Yongmei, Shi, Gang, Kuusisto, Johanna, Tayo, Bamidele, Seielstad, Mark, Sim, Xueling, Hoang Nguyen, Khanh-Dung, Lehtimäki, Terho, Matullo, Giuseppe, Wu, Ying, Gaunt, Tom R., Charlotte Onland-Moret, N., Cooper, Matthew N., Platou, Carl G. P., Org, Elin, Hardy, Rebecca, Dahgam, Santosh, Palmen, Jutta, Vitart, Veronique, Braund, Peter S., Kuznetsova, Tatiana, Uiterwaal, Cuno S. P. M., Adeyemo, Adebowale, Palmas, Walter, Campbell, Harry, Ludwig, Barbara, Tomaszewski, Maciej, Tzoulaki, Ioanna, Palmer, Nicholette D., Aspelund, Thor, Garcia, Melissa, Chang, Yen-Pei C., O'Connell, Jeffrey R., Steinle, Nanette I., Grobbee, Diederick E., Arking, Dan E., Kardia, Sharon L., Morrison, Alanna C., Hernandez, Dena, Najjar, Samer, McArdle, Wendy L., Hadley, David, Brown, Morris J., Connell, John M., Hingorani, Aroon D., Day, Ian N. M., Lawlor, Debbie A., Beilby, John P., Lawrence, Robert W., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Dreisbach, Albert W., Li, Yali, Hunter Young, J., Bis, Joshua C., Kähönen, Mika, Viikari, Jorma, Adair, Linda S., Lee, Nanette R., Chen, Ming-Huei, Olden, Matthias, Pattaro, Cristian, Bolton, Judith A Hoffman, Köttgen, Anna, Bergmann, Sven, Mooser, Vincent, Chaturvedi, Nish, Frayling, Timothy M., Islam, Muhammad, Jafar, Tazeen H., Erdmann, Jeanette, Kulkarni, Smita R., Bornstein, Stefan R., Grässler, Jürgen, Groop, Leif, Voight, Benjamin F., Kettunen, Johannes, Howard, Philip, Taylor, Andrew, Guarrera, Simonetta, Ricceri, Fulvio, Emilsson, Valur, Plump, Andrew, Barroso, Inês, Khaw, Kay-Tee, Weder, Alan B., Hunt, Steven C., Sun, Yan V., Bergman, Richard N., Collins, Francis S., Bonnycastle, Lori L., Scott, Laura J., Stringham, Heather M., Peltonen, Leena, Perola, Markus, Vartiainen, Erkki, Brand, Stefan-Martin, Staessen, Jan A., Wang, Thomas J., Burton, Paul R., Artigas, Maria Soler, Dong, Yanbin, Snieder, Harold, Wang, Xiaoling, Zhu, Haidong, Lohman, Kurt K., Rudock, Megan E., Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Doumatey, Ayo, Shriner, Daniel, Veldre, Gudrun, Viigimaa, Margus, Kinra, Sanjay, Prabhakaran, Dorairaj, Tripathy, Vikal, Langefeld, Carl D., Rosengren, Annika, Thelle, Dag S., Corsi, Anna Maria, Singleton, Andrew, Forrester, Terrence, Hilton, Gina, McKenzie, Colin A., Salako, Tunde, Iwai, Naoharu, Kita, Yoshikuni, Ogihara, Toshio, Ohkubo, Takayoshi, Okamura, Tomonori, Ueshima, Hirotsugu, Umemura, Satoshi, Eyheramendy, Susana, Meitinger, Thomas, Wichmann, H. -Erich, Cho, Yoon Shin, Kim, Hyung-Lae, Lee, Jong-Young, Scott, James, Sehmi, Joban S., Zhang, Weihua, Hedblad, Bo, Nilsson, Peter, Smith, George Davey, Wong, Andrew, Narisu, Narisu, Stančáková, Alena, Raffel, Leslie J., Yao, Jie, Kathiresan, Sekar, O'Donnell, Christopher J., Schwartz, Stephen M., Arfan Ikram, M., Longstreth Jr. , W. T., Mosley, Thomas H., Seshadri, Sudha, Shrine, Nick R. G., Wain, Louise V., Morken, Mario A., Swift, Amy J., Laitinen, Jaana, Prokopenko, Inga, Zitting, Paavo, Cooper, Jackie A., Humphries, Steve E., Danesh, John, Rasheed, Asif, Goel, Anuj, Hamsten, Anders, Watkins, Hugh, Bakker, Stephan J. L., van Gilst, Wiek H., Janipalli, Charles S., Radha Mani, K., Yajnik, Chittaranjan S., Hofman, Albert, Mattace-Raso, Francesco U. S., Oostra, Ben A., Demirkan, Ayse, Isaacs, Aaron, Rivadeneira, Fernando, Lakatta, Edward G., Orru, Marco, Scuteri, Angelo, Ala-Korpela, Mika, Kangas, Antti J., Lyytikäinen, Leo-Pekka, Soininen, Pasi, Tukiainen, Taru, Würtz, Peter, Twee-HeeOng, Rick, Dörr, Marcus, Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Zelenika, Diana, Deloukas, Panos, Mangino, Massimo, Spector, Tim D., Zhai, Guangju, Meschia, James F., Nalls, Michael A., Sharma, Pankaj, Terzic, Janos, Kranthi Kumar, M. V., Denniff, Matthew, Zukowska-Szczechowska, Ewa, Wagenknecht, Lynne E., Fowkes, F. Gerald R., Charchar, Fadi J., Schwarz, Peter E. 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Amsterdam institute for Infection and Immunity, Nephrology, Epidemiologie, RS: CARIM School for Cardiovascular Diseases, Epidemiology, Medical Microbiology & Infectious Diseases, Radiology & Nuclear Medicine, Cardiology, Internal Medicine, Clinical Genetics, Erasmus MC other, Obstetrics & Gynecology, International Consortium for Blood Pressure Genome-Wide Association Studies, CARDIoGRAM consortium, CKDGen Consortium, KidneyGen Consortium, EchoGen consortium, CHARGE-HF consortium, Zhao, Jing Hua [0000-0003-4930-3582], Luan, Jian'an [0000-0003-3137-6337], Barroso, Ines [0000-0001-5800-4520], Khaw, Kay-Tee [0000-0002-8802-2903], Danesh, John [0000-0003-1158-6791], Soranzo, Nicole [0000-0003-1095-3852], Wareham, Nicholas [0000-0003-1422-2993], Apollo - University of Cambridge Repository, Life Course Epidemiology (LCE), Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Center for Complex Disease Genomics, Johns Hopkins University School of Medicine, Clinical Pharmacology and The Genome Centre, Queen Mary University of London (QMUL), Framingham Heart Study, Boston University [Boston] (BU)-National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), National Heart, Lung, and Blood Institute [Bethesda] (NHLBI), Center for Human Genetic Research, Massachusetts General Hospital [Boston], Program in Medical and Population Genetics, Harvard University-Massachusetts Institute of Technology (MIT), Ehret, Georg B., Munroe, Patricia B., Rice, Kenneth M., Bochud, Murielle, Johnson, Andrew D., Chasman, Daniel I., Smith, Albert V., Tobin, Martin D., Verwoert, Germaine C., Hwang, Shih-Jen, Pihur, Vasyl, Vollenweider, Peter, O'Reilly, Paul F., Amin, Najaf, Bragg-Gresham, Jennifer L., Teumer, Alexander, Glazer, Nicole L., Launer, Lenore, Zhao, Jing Hua, Aulchenko, Yurii, Heath, Simon, Sober, Siim, Parsa, Afshin, Luan, Jian'An, Arora, Pankaj, Dehghan, Abba, Zhang, Feng, Lucas, Gavin, Hicks, Andrew A., Jackson, Anne U., Peden, John F., Tanaka, Toshiko, Wild, Sarah H., Rudan, Igor, Igl, Wilmar, Milaneschi, Yuri, Parker, Alex N., Fava, Cristiano, Chambers, John C., Fox, Ervin R., Kumari, Meena, Go, Min Jin, van der Harst, Pim, Kao, Wen Hong Linda, Sjögren, Marketa, Vinay, D. G., Alexander, Myriam, Tabara, Yasuharu, Shaw-Hawkins, Sue, Whincup, Peter H., Liu, Yongmei, Shi, Gang, Kuusisto, Johanna, Tayo, Bamidele, Seielstad, Mark, Sim, Xueling, Hoang Nguyen, Khanh-Dung, Lehtimäki, Terho, Matullo, Giuseppe, Wu, Ying, Gaunt, Tom R., Charlotte Onland-Moret, N., Cooper, Matthew N., Platou, Carl G. P., Org, Elin, Hardy, Rebecca, Dahgam, Santosh, Palmen, Jutta, Vitart, Veronique, Braund, Peter S., Kuznetsova, Tatiana, Uiterwaal, Cuno S. P. M., Adeyemo, Adebowale, Palmas, Walter, Campbell, Harry, Ludwig, Barbara, Tomaszewski, Maciej, Tzoulaki, Ioanna, Palmer, Nicholette D., Aspelund, Thor, Garcia, Melissa, Chang, Yen-Pei C., O'Connell, Jeffrey R., Steinle, Nanette I., Grobbee, Diederick E., Arking, Dan E., Kardia, Sharon L., Morrison, Alanna C., Hernandez, Dena, Najjar, Samer, Mcardle, Wendy L., Hadley, David, Brown, Morris J., Connell, John M., Hingorani, Aroon D., Day, Ian N. M., Lawlor, Debbie A., Beilby, John P., Lawrence, Robert W., Clarke, Robert, Hopewell, Jemma C., Ongen, Halit, Dreisbach, Albert W., Li, Yali, Hunter Young, J., Bis, Joshua C., Kähönen, Mika, Viikari, Jorma, Adair, Linda S., Lee, Nanette R., Chen, Ming-Huei, Olden, Matthia, Pattaro, Cristian, Bolton, Judith A Hoffman, Köttgen, Anna, Bergmann, Sven, Mooser, Vincent, Chaturvedi, Nish, Frayling, Timothy M., Islam, Muhammad, Jafar, Tazeen H., Erdmann, Jeanette, Kulkarni, Smita R., Bornstein, Stefan R., Grässler, Jürgen, Groop, Leif, Voight, Benjamin F., Kettunen, Johanne, Howard, Philip, Taylor, Andrew, Guarrera, Simonetta, Ricceri, Fulvio, Emilsson, Valur, Plump, Andrew, Barroso, Inê, Khaw, Kay-Tee, Weder, Alan B., Hunt, Steven C., Sun, Yan V., Bergman, Richard N., Collins, Francis S., Bonnycastle, Lori L., Scott, Laura J., Stringham, Heather M., Peltonen, Leena, Perola, Marku, Vartiainen, Erkki, Brand, Stefan-Martin, Staessen, Jan A., Wang, Thomas J., Burton, Paul R., Artigas, Maria Soler, Dong, Yanbin, Snieder, Harold, Wang, Xiaoling, Zhu, Haidong, Lohman, Kurt K., Rudock, Megan E., Heckbert, Susan R., Smith, Nicholas L., Wiggins, Kerri L., Doumatey, Ayo, Shriner, Daniel, Veldre, Gudrun, Viigimaa, Margu, Kinra, Sanjay, Prabhakaran, Dorairaj, Tripathy, Vikal, Langefeld, Carl D., Rosengren, Annika, Thelle, Dag S., Corsi, Anna Maria, Singleton, Andrew, Forrester, Terrence, Hilton, Gina, Mckenzie, Colin A., Salako, Tunde, Iwai, Naoharu, Kita, Yoshikuni, Ogihara, Toshio, Ohkubo, Takayoshi, Okamura, Tomonori, Ueshima, Hirotsugu, Umemura, Satoshi, Eyheramendy, Susana, Meitinger, Thoma, Wichmann, H. -Erich, Cho, Yoon Shin, Kim, Hyung-Lae, Lee, Jong-Young, Scott, Jame, Sehmi, Joban S., Zhang, Weihua, Hedblad, Bo, Nilsson, Peter, Smith, George Davey, Wong, Andrew, Narisu, Narisu, Stančáková, Alena, Raffel, Leslie J., Yao, Jie, Kathiresan, Sekar, O'Donnell, Christopher J., Schwartz, Stephen M., Arfan Ikram, M., Longstreth Jr., W. T., Mosley, Thomas H., Seshadri, Sudha, Shrine, Nick R. G., Wain, Louise V., Morken, Mario A., Swift, Amy J., Laitinen, Jaana, Prokopenko, Inga, Zitting, Paavo, Cooper, Jackie A., Humphries, Steve E., Danesh, John, Rasheed, Asif, Goel, Anuj, Hamsten, Ander, Watkins, Hugh, Bakker, Stephan J. L., van Gilst, Wiek H., Janipalli, Charles S., Radha Mani, K., Yajnik, Chittaranjan S., Hofman, Albert, Mattace-Raso, Francesco U. S., Oostra, Ben A., Demirkan, Ayse, Isaacs, Aaron, Rivadeneira, Fernando, Lakatta, Edward G., Orru, Marco, Scuteri, Angelo, Ala-Korpela, Mika, Kangas, Antti J., Lyytikäinen, Leo-Pekka, Soininen, Pasi, Tukiainen, Taru, Würtz, Peter, Twee-HeeOng, Rick, Dörr, Marcu, Kroemer, Heyo K., Völker, Uwe, Völzke, Henry, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Zelenika, Diana, Deloukas, Pano, Mangino, Massimo, Spector, Tim D., Zhai, Guangju, Meschia, James F., Nalls, Michael A., Sharma, Pankaj, Terzic, Jano, Kranthi Kumar, M. V., Denniff, Matthew, Zukowska-Szczechowska, Ewa, Wagenknecht, Lynne E., Fowkes, F. Gerald R., Charchar, Fadi J., Schwarz, Peter E. H., Hayward, Caroline, Guo, Xiuqing, Rotimi, Charle, Bots, Michiel L., Brand, Eva, Samani, Nilesh J., Polasek, Ozren, Talmud, Philippa J., Nyberg, Fredrik, Kuh, Diana, Laan, Mari, Hveem, Kristian, Palmer, Lyle J., van der Schouw, Yvonne T., Casas, Juan P., Mohlke, Karen L., Vineis, Paolo, Raitakari, Olli, Ganesh, Santhi K., Wong, Tien Y., Shyong Tai, E., Cooper, Richard S., Laakso, Markku, Rao, Dabeeru C., Harris, Tamara B., Morris, Richard W., Dominiczak, Anna F., Kivimaki, Mika, Marmot, Michael G., Miki, Tetsuro, Saleheen, Danish, Chandak, Giriraj R., Coresh, Josef, Navis, Gerjan, Salomaa, Veikko, Han, Bok-Ghee, Zhu, Xiaofeng, Kooner, Jaspal S., Melander, Olle, Ridker, Paul M., Bandinelli, Stefania, Gyllensten, Ulf B., Wright, Alan F., Wilson, James F., Ferrucci, Luigi, Farrall, Martin, Tuomilehto, Jaakko, Pramstaller, Peter P., Elosua, Roberto, Soranzo, Nicole, Sijbrands, Eric J. G., Altshuler, David, Loos, Ruth J. F., Shuldiner, Alan R., Gieger, Christian, Meneton, Pierre, Uitterlinden, Andre G., Wareham, Nicholas J., Gudnason, Vilmundur, Rotter, Jerome I., Rettig, Rainer, Uda, Manuela, Strachan, David P., Witteman, Jacqueline C. M., Hartikainen, Anna-Liisa, Beckmann, Jacques S., Boerwinkle, Eric, Vasan, Ramachandran S., Boehnke, Michael, Larson, Martin G., Järvelin, Marjo-Riitta, Psaty, Bruce M., Abecasis, Gonçalo R., Chakravarti, Aravinda, Elliott, Paul, van Duijn, Cornelia M., Newton-Cheh, Christopher, Levy, Daniel, Caulfield, Mark J., Johnson, Toby, Tang, H, Knowles, J, Hlatky, M, Fortmann, S, Assimes, Tl, Quertermous, T, Go, A, Iribarren, C, Absher, D, Risch, N, Meyers, R, Sidney, S, Ziegler, A, Schillert, A, Bickel, C, Sinning, C, Rupprecht, Hj, Lackner, K, Wild, P, Schnabel, R, Blankenberg, S, Zeller, T, Münzel, T, Perret, C, Cambien, F, Tiret, L, Nicaud, V, Proust, C, Dehghan, A, Hofman, A, Uitterlinden, A, van Duijn, C, Levy, D, Whitteman, J, Cupples, La, Demissie-Banjaw, S, Ramachandran, V, Smith, A, Gudnason, V, Boerwinkle, E, Folsom, A, Morrison, A, Psaty, Bm, Chen, Iy, Rotter, Ji, Bis, J, Volcik, K, Rice, K, Taylor, Kd, Marciante, K, Smith, N, Glazer, N, Heckbert, S, Harris, T, Lumley, T, Kong, A, Thorleifsson, G, Thorgeirsson, G, Holm, H, Gulcher, Jr, Stefansson, K, Andersen, K, Gretarsdottir, S, Thorsteinsdottir, U, Preuss, M, Schreiber, S, Meitinger, T, König, Ir, Lieb, W, Hengstenberg, C, Schunkert, H, Erdmann, J, Fisher, M, Grosshennig, A, Medack, A, Stark, K, Linsel-Nitschke, P, Bruse, P, Aherrahrou, Z, Peters, A, Loley, C, Willenborg, C, Nahrstedt, J, Freyer, J, Gulde, S, Doering, A, Meisinger, C, Wichmann, He, Klopp, N, Illig, T, Meinitzer, A, Tomaschitz, A, Halperin, E, Dobnig, H, Scharnagl, H, Kleber, M, Laaksonen, R, Pilz, S, Grammer, Tb, Stojakovic, T, Renner, W, März, W, Böhm, Bo, Winkelmann, Br, Winkler, K, Hoffmann, M, O'Donnell, Cj, Voight, Bf, Altshuler, D, Siscovick, D, Musunuru, K, Peltonen, L, Barbalic, M, Melander, O, Elosua, R, Kathiresan, S, Schwartz, Sm, Salomaa, V, Guiducci, C, Burtt, N, Gabriel, Sb, Stewart, Af, Wells, Ga, Chen, L, Jarinova, O, Roberts, R, Mcpherson, R, Dandona, S, Pichard, Ad, Rader, Dj, Devaney, J, Lindsay, Jm, Kent, Km, Qu, L, Satler, L, Burnett, M, Li, M, Reilly, Mp, Wilensky, R, Waksman, R, Epstein, S, Mattha, W, Knouf, Cw, Waterworth, Dm, Hakonarson, Hh, Walker, M, Mooser, V, Hall, A, Balmforth, Aj, Wright, Bj, Nelson, C, Thompson, Jr, Samani, Nj, Braund, P, Ball, Sg, Smith, Nl, Felix, Jf, Morrison, Ac, Demissie, S, Glazer, Nl, Loehr, Lr, Rosamond, Wd, Rivadeneira, F, Bis, Jc, Folsom, Ar, Benjamin, E, Aulchenko, Y, Haritunians, T, Couper, D, Murabito, J, Wang, Ya, Stricker, B, Gottdiener, J, Chang, Pp, Wang, Tj, Rice, Km, Heckbert, Sr, Fox, Er, Uitterlinden, Ag, Willerson, Jt, van Duijn, Cm, Witteman, Jc, Vasan, R, Köttgen, A, Pattaro, C, Böger, Ca, Fuchsberger, C, Olden, M, Parsa, A, Gao, X, Yang, Q, Smith, Av, O'Connell, Jr, Schmidt, H, Tanaka, T, Isaacs, A, Ketkar, S, Hwang, Sj, Johnson, A, Teumer, A, Paré, G, Atkinson, Ej, Lohman, K, Cornelis, Mc, Probst-Hensch, Nm, Kronenberg, F, Tönjes, A, Hayward, C, Aspelund, T, Eiriksdottir, G, Launer, Lj, Harris, Tb, Rampersaud, E, Mitchell, Bd, Arking, De, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, Francesco, Metter, J, de Boer, J, Zillikens, Mc, Oostra, Ba, Feitosa, M, Province, M, de Andrade, M, Turne, St, Schnabel, Rb, Wilde, S, Munzel, Tf, Leak, T, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, Fb, Johansson, A, Igl, W, Zaboli, G, Wild, Sh, Wright, Af, Campbell, H, Ellinghaus, D, Imboden, M, Nitsch, D, Brandstätter, A, Kollerits, B, Kedenko, L, Mägi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Völzke, H, Kroemer, Hk, Nauck, M, Völker, U, Polasek, O, Vitart, V, Badola, S, Parker, An, Ridker, Pm, Kardia, Sl, Liu, Y, Curhan, Gc, Franke, A, Rochat, T, Paulweber, B, Prokopenko, I, Wang, W, Shuldiner, Ar, Coresh, J, Schmidt, R, Ferrucci, L, Shlipak, Mg, Borecki, I, Krämer, Bk, Rudan, I, Gyllensten, U, Wilson, Jf, Pramstaller, Pp, Rettig, R, Hastie, N, Chasman, Di, Kao, Wh, Heid, Im, Fox, C, Felix, Sb, Watzinger, N, Larson, Mg, Homuth, G, Aragam, J, Dörr, M, Zweiker, R, Lind, L, Rodeheffer, Rj, Greiser, Kh, Deckers, Jw, Stritzke, J, Lackner, Kj, Ingelsson, E, Kullo, I, Haerting, J, Stricker, Bh, Reffelmann, T, Redfield, Mm, Werdan, K, Mitchell, Gf, Arnett, D, Blettner, M, Friedrich, N, Benjamin, Ej, Chambers, Jc, Zhang, W, Lord, Gm, van der Harst, P, Lawlor, Da, Sehmi, J, Gale, Dp, Wass, Mn, Ahmadi, Kr, Bakker, Sj, Beckmann, J, Bilo, Hj, Bochud, M, Brown, Mj, Caulfield, Mj, Connell, Jm, Cook, Ht, Cotlarciuc, I, Davey Smith, G, de Silva, R, Deng, G, Devuyst, O, Dikkeschei, Ld, Dimkovic, T, Dockrell, M, Dominiczak, A, Ebrahim, S, Eggermann, T, Farrall, M, Floege, J, Forouhi, Ng, Gansevoort, Rt, Han, X, Hedblad, B, Homan van der Heide, Jj, Hepkema, Bg, Hernandez-Fuentes, M, Hypponen, E, Johnson, T, de Jong, Pe, Kleefstra, N, Lagou, V, Lapsley, M, Li, Y, Loos, Rj, Luan, J, Luttropp, K, Maréchal, C, Munroe, Pb, Nordfors, L, Penninx, Bw, Perucha, E, Pouta, A, Roderick, Pj, Ruokonen, A, Sanna, S, Schalling, M, Schlessinger, D, Schlieper, G, Seelen, Ma, Sjögren, M, Smit, Jh, Snieder, H, Soranzo, N, Spector, Td, Stenvinkel, P, Sternberg, Mj, Swaminathan, R, Ubink-Veltmaat, Lj, Uda, M, Vollenweider, P, Wallace, C, Waterworth, D, Zerres, K, Waeber, G, Wareham, Nj, Maxwell, Ph, Mccarthy, Mi, Jarvelin, Mr, Abecasis, Gr, Lightstone, L, Scott, J, Navis, G, Elliot, P, and Kooner, Js.
Subjects: novel loci, Kidney Disease, Polymorphism, Single Nucleotide/*genetics, [SDV]Life Sciences [q-bio], left ventricular wall thickness, LOCI, Genome-wide association study, Blood Pressure, Disease, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary artery disease, 0302 clinical medicine, RELEVANCE, Africa/ethnology, Cardiovascular Disease, genetics, Kidney Diseases/genetics, Stroke, genome wide association study, POPULATION, ta118, Blood pressure, hypertension, stroke, coronary artery disease, ddc:616, 0303 health sciences, education.field_of_study, Asia/ethnology, Multidisciplinary, Coronary Artery Disease/genetics, COMMON VARIANTS, Genetic Predisposition to Disease/*genetics, 3. Good health, Europe, Cardiovascular Diseases, Hypertension, Cardiology, Kidney Diseases, HEALTH, Human, medicine.medical_specialty, Asia, Population, Renal function, Polymorphism, Single Nucleotide, Europe/ethnology, Article, CLONING, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Stroke/genetics, Internal medicine, medicine, Humans, Cardiovascular Diseases/*genetics, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, education, METAANALYSIS, 030304 developmental biology, RECEPTOR, genes, blood pressure, cardiovascular disease risk, medicine.disease, Africa, Blood Pressure/*genetics/physiology, Hypertension/genetics, Kidney disease, Genome-Wide Association Study
Abstract: Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention. ispartof: Nature vol:478 issue:7367 pages:103-109 ispartof: location:England status: published
Published: 2011

23. Gastrointestinal tract metastasis from tubulolobular carcinoma of the breast: a case report and review of the literature

Author: Wang GX, Wang TJ, Jiang J, Zhou LY, and Zhao HD
Subjects: lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282
Abstract: Guixin Wang, Tingjiang Wang, Jian Jiang, Luyao Zhou, Haidong Zhao Department of Breast Surgery, The Second Affiliated Hospital of Dalian Medical University, Shahekou District, Dalian, Liaoning Province, People's Republic of China Abstract: Metastasis of breast cancer into the gastrointestinal tract happens rarely. The diagnosis of this kind of disease is difficult because of the nonspecific symptoms and the long interval between primary manifestations and recurrence. Awareness of this condition may lead to an accurate diagnosis and an earlier initiation of systemic treatment, thus avoiding unnecessary surgical intervention. In this paper, we report a rare case of a patient with tubulolobular carcinoma metastases to the colon, presenting with abdominal pain, discomfort, and weight loss. The patient underwent radical mastectomy and received postoperative radiotherapy and chemotherapy. Ten years later, she presented with gastrointestinal tract symptoms. Surgery combined with systemic treatment was chosen for the colon lesion. Immunohistochemical staining suggested a breast origin. The patient was still living 24 months after the diagnosis of the metastasis. This is the fourth case report in our literature review. Keywords: breast cancer, tubulolobular carcinoma, metastasis, gastrointestinal tract
Published: 2014

24. Low-velocity impact of multilayer sandwich beams with metal foam cores: Analytical, experimental, and numerical investigations.

Author: Zhang, Jianxun, Qin, Qinghua, Chen, Shangjun, Yang, Yan, Ye, Yang, Xiang, Chunping, and Wang, TJ
Subjects: METAL foams, DEFLECTION (Mechanics), INVESTIGATIONS, NUMERICAL calculations, FOAM, IMPACT response, SANDWICH construction (Materials)
Abstract: This paper uses the analytical, experimental and numerical methods to investigate the low-velocity impact response of fully clamped multilayer sandwich beams with metal foam cores struck by a heavy mass. Using the quasi-static method, analytical solutions for dynamic response of the fully clamped multilayer sandwich beams are derived including the interaction between bending and stretching induced by large deflections. Effects of local denting and core strength on the overall bending are considered. The low-velocity impact experiments and numerical calculations are carried out to validate the analytical model. The present analytical model captures experimental and numerical results reasonably. It is shown that the energy absorption of multilayer sandwich beams increases with decrease of multilayer factor and increase of the core strength. [ABSTRACT FROM AUTHOR]
Published: 2020
Full Text: View/download PDF

25. Low-velocity impact of multilayer sandwich beams with metal foam cores: Analytical, experimental, and numerical investigations

Author: Zhang, Jianxun, primary, Qin, Qinghua, additional, Chen, Shangjun, additional, Yang, Yan, additional, Ye, Yang, additional, Xiang, Chunping, additional, and Wang, TJ, additional
Published: 2018
Full Text: View/download PDF

26. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Author: ICBP Consortium, AGEN Consortium, CHARGe-Heart Failure Group, ECHOGen Consortium, CARDIOGRAM, Abecasis, GR., Adair, LS., Alexander, M., Altshuler, D., Amin, N., Arking, DE., Arora, P., Aulchenko, Y., Bakker, SJ., Bandinelli, S., Barroso, I., Beckmann, JS., Beilby, JP., Bergman, RN., Bergmann, S., Bis, JC., Boehnke, M., Bonnycastle, LL., Bornstein, SR., Bots, ML., Bragg-Gresham, JL., Brand, SM., Brand, E., Braund, PS., Brown, MJ., Burton, PR., Casas, JP., Caulfield, MJ., Chakravarti, A., Chambers, JC., Chandak, GR., Chang, YP., Charchar, FJ., Chaturvedi, N., Shin Cho, Y., Clarke, R., Collins, FS., Collins, R., Connell, JM., Cooper, JA., Cooper, MN., Cooper, RS., Corsi, AM., Dörr, M., Dahgam, S., Danesh, J., Davey Smith, G., Day, IN., Deloukas, P., Denniff, M., Dominiczak, AF., Dong, Y., Doumatey, A., Elliott, P., Elosua, R., Erdmann, J., Eyheramendy, S., Farrall, M., Fava, C., Forrester, T., Fowkes, FG., Fox, ER., Frayling, TM., Galan, P., Ganesh, SK., Garcia, M., Gaunt, TR., Glazer, NL., Go, MJ., Goel, A., Grässler, J., Grobbee, DE., Groop, L., Guarrera, S., Guo, X., Hadley, D., Hamsten, A., Han, BG., Hardy, R., Hartikainen, AL., Heath, S., Heckbert, SR., Hedblad, B., Hercberg, S., Hernandez, D., Hicks, AA., Hilton, G., Hingorani, AD., Bolton, JA., Hopewell, JC., Howard, P., Humphries, SE., Hunt, SC., Hveem, K., Ikram, MA., Islam, M., Iwai, N., Jarvelin, MR., Jackson, AU., Jafar, TH., Janipalli, CS., Johnson, T., Kathiresan, S., Khaw, KT., Kim, HL., Kinra, S., Kita, Y., Kivimaki, M., Kooner, JS., Kumar, MJ., Kuh, D., Kulkarni, SR., Kumari, M., Kuusisto, J., Kuznetsova, T., Laakso, M., Laan, M., Laitinen, J., Lakatta, EG., Langefeld, CD., Larson, MG., Lathrop, M., Lawlor, DA., Lawrence, RW., Lee, JY., Lee, NR., Levy, D., Li, Y., Longstreth, WT., Luan£££Jian'an£££ J., Lucas, G., Ludwig, B., Mangino, M., Mani, KR., Marmot, MG., Mattace-Raso, FU., Matullo, G., McArdle, WL., McKenzie, CA., Meitinger, T., Melander, O., Meneton, P., Meschia, JF., Miki, T., Milaneschi, Y., Mohlke, KL., Mooser, V., Morken, MA., Morris, RW., Mosley, TH., Najjar, S., Narisu, N., Newton-Cheh, C., Nguyen, KD., Nilsson, P., Nyberg, F., O'Donnell, CJ., Ogihara, T., Ohkubo, T., Okamura, T., Ong, RT., Ongen, H., Onland-Moret, NC., O'Reilly, PF., Org, E., Orru, M., Palmas, W., Palmen, J., Palmer, LJ., Palmer, ND., Parker, AN., Peden, JF., Peltonen, L., Perola, M., Pihur, V., Platou, CG., Plump, A., Prabhakaran, D., Psaty, BM., Raffel, LJ., Rao, DC., Rasheed, A., Ricceri, F., Rice, KM., Rosengren, A., Rotter, JI., Rudock, ME., Sõber, S., Salako, T., Saleheen, D., Salomaa, V., Samani, NJ., Schwartz, SM., Schwarz, PE., Scott, LJ., Scott, J., Scuteri, A., Sehmi, JS., Seielstad, M., Seshadri, S., Sharma, P., Shaw-Hawkins, S., Shi, G., Shrine, NR., Sijbrands, EJ., Sim, X., Singleton, A., Sjögren, M., Smith, NL., Soler Artigas, M., Spector, TD., Staessen, JA., Stancakova, A., Steinle, NI., Strachan, DP., Stringham, HM., Sun, YV., Swift, AJ., Tabara, Y., Tai, ES., Talmud, PJ., Taylor, A., Terzic, J., Thelle, DS., Tobin, MD., Tomaszewski, M., Tripathy, V., Tuomilehto, J., Tzoulaki, I., Uda, M., Ueshima, H., Uiterwaal, CS., Umemura, S., van der Harst, P., van der Schouw YT., van Gilst WH., Vartiainen, E., Vasan, RS., Veldre, G., Verwoert, GC., Viigimaa, M., Vinay, DG., Vineis, P., Voight, BF., Vollenweider, P., Wagenknecht, LE., Wain, LV., Wang, X., Wang, TJ., Wareham, NJ., Watkins, H., Weder, AB., Whincup, PH., Wiggins, KL., Witteman, JC., Wong, A., Wu, Y., Yajnik, CS., Yao, J., Young, JH., Zelenika, D., Zhai, G., Zhang, W., Zhang, F., Zhao, JH., Zhu, H., Zhu, X., Zitting, P., Zukowska-Szczechowska, E., Okada, Y., Wu, JY., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, SC., Wong, TY., Liu, J., Young, TL., Aung, T., Teo, YY., Kim, YJ., Kang, D., Chen, CH., Tsai, FJ., Chang, LC., Fann, SJ., Mei, H., Hixson, JE., Chen, S., Katsuya, T., Isono, M., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, YT., Tanaka, T., Reilly, MP., Schunkert, H., Assimes, TL., Hall, A., Hengstenberg, C., König, IR., Laaksonen, R., McPherson, R., Thompson, JR., Thorsteinsdottir, U., Ziegler, A., Absher, D., Chen, L., Cupples, LA., Halperin, E., Li, M., Musunuru, K., Preuss, M., Schillert, A., Thorleifsson, G., Wells, GA., Holm, H., Roberts, R., Stewart, AF., Fortmann, S., Go, A., Hlatky, M., Iribarren, C., Knowles, J., Myers, R., Quertermous, T., Sidney, S., Risch, N., Tang, H., Blankenberg, S., Schnabel, R., Sinning, C., Lackner, KJ., Tiret, L., Nicaud, V., Cambien, F., Bickel, C., Rupprecht, HJ., Perret, C., Proust, C., Münzel, TF., Barbalic, M., Chen, IY., Demissie-Banjaw, S., Folsom, A., Lumley, T., Marciante, K., Taylor, KD., Volcik, K., Gretarsdottir, S., Gulcher, JR., Kong, A., Stefansson, K., Thorgeirsson, G., Andersen, K., Fischer, M., Grosshennig, A., Linsel-Nitschke, P., Stark, K., Schreiber, S., Aherrahrou, Z., Bruse, P., Doering, A., Klopp, N., Diemert, P., Loley, C., 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Boerwinkle, E., Salvi, E., Bottinger, E.P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F.B., Navis, G.J., Curhan, G.C., Ehret, G.B., Homuth, G., Coassin, S., Thun, G.A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G.W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H.E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H.K., Kramer, H., Lin, H., Leach, I.M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I.M., Kolcic, I., Persico, I., Jukema, J.W., Wilson, J.F., Felix, J.F., Divers, J., Lambert, J.C., Stafford, J.M., Gaspoz, J.M., Smith, J.A., Faul, J.D., Wang, J.J., Ding, J., Hirschhorn, J.N., Attia, J., Whitfield, J.B., Chalmers, J., Viikari, J., Coresh, J., Denny, J.C., Karjalainen, J., Fernandes, J.K., Endlich, K., Butterbach, K., Keene, K.L., Lohman, K., Portas, L., Launer, L.J., Lyytikäinen, L.P., Yengo, L., Franke, L., Ferrucci, L., Rose, L.M., Kedenko, L., Rao, M., Struchalin, M., Kleber, M.E., Cavalieri, M., Haun, M., Cornelis, M.C., Ciullo, M., Pirastu, M., de Andrade, M., McEvoy, M.A., Woodward, M., Adam, M., Cocca, M., Nauck, M., Imboden, M., Waldenberger, M., Pruijm, M., Metzger, M., Stumvoll, M., Evans, M.K., Sale, M.M., Kähönen, M., Boban, M., Bochud, M., Rheinberger, M., Verweij, N., Bouatia-Naji, N., Martin, N.G., Hastie, N., Probst-Hensch, N., Soranzo, N., Devuyst, O., Raitakari, O., Gottesman, O., Franco, O.H., Polasek, O., Gasparini, P., Munroe, P.B., Ridker, P.M., Mitchell, P., Muntner, P., Meisinger, C., Smit, J.H., Kovacs, P., Wild, P.S., Froguel, P., Rettig, R., Mägi, R., Biffar, R., Schmidt, R., Middelberg, R.P., Carroll, R.J., Penninx, B.W., Scott, R.J., Katz, R., Sedaghat, S., Wild, S.H., Kardia, S.L., Ulivi, S., Hwang, S.J., Enroth, S., Kloiber, S., Trompet, S., Stengel, B., Hancock, S.J., Turner, S.T., Rosas, S.E., Stracke, S., Harris, T.B., Zeller, T., Zemunik, T., Lehtimäki, T., Illig, T., Aspelund, T., Nikopensius, T., Esko, T., Gyllensten, U., Völker, U., Emilsson, V., Vitart, V., Aalto, V., Gudnason, V., Chouraki, V., Chen, W.M., Igl, W., März, W., Koenig, W., Lieb, W., Loos, R.J., Liu, Y., Snieder, H., Pramstaller, P.P., Parsa, A., O'Connell, J.R., Susztak, K., Hamet, P., Tremblay, J., de Boer, I.H., Böger, C.A., Goessling, W., Chasman, D.I., Köttgen, A., Kao, W.H., Fox, C.S., ICBP Consortium, AGEN Consortium, CHARGe-Heart Failure Group, ECHOGen Consortium, CARDIOGRAM, Abecasis, GR., Adair, LS., Alexander, M., Altshuler, D., Amin, N., Arking, DE., Arora, P., Aulchenko, Y., Bakker, SJ., Bandinelli, S., Barroso, I., Beckmann, JS., Beilby, JP., Bergman, RN., Bergmann, S., Bis, JC., Boehnke, M., Bonnycastle, LL., Bornstein, SR., Bots, ML., Bragg-Gresham, JL., Brand, SM., Brand, E., Braund, PS., Brown, MJ., Burton, PR., Casas, JP., Caulfield, MJ., Chakravarti, A., Chambers, JC., Chandak, GR., Chang, YP., Charchar, FJ., Chaturvedi, N., Shin Cho, Y., Clarke, R., Collins, FS., Collins, R., Connell, JM., Cooper, JA., Cooper, MN., Cooper, RS., Corsi, AM., Dörr, M., Dahgam, S., Danesh, J., Davey Smith, G., Day, IN., Deloukas, P., Denniff, M., Dominiczak, AF., Dong, Y., Doumatey, A., Elliott, P., Elosua, R., Erdmann, J., Eyheramendy, S., Farrall, M., Fava, C., Forrester, T., Fowkes, FG., Fox, ER., Frayling, TM., Galan, P., Ganesh, SK., Garcia, M., Gaunt, TR., Glazer, NL., Go, MJ., Goel, A., Grässler, J., Grobbee, DE., Groop, L., Guarrera, S., Guo, X., Hadley, D., Hamsten, A., Han, BG., Hardy, R., Hartikainen, AL., Heath, S., Heckbert, SR., Hedblad, B., Hercberg, S., Hernandez, D., Hicks, AA., Hilton, G., Hingorani, AD., Bolton, JA., Hopewell, JC., Howard, P., Humphries, SE., Hunt, SC., Hveem, K., Ikram, MA., Islam, M., Iwai, N., Jarvelin, MR., Jackson, AU., Jafar, TH., Janipalli, CS., Johnson, T., Kathiresan, S., Khaw, KT., Kim, HL., Kinra, S., Kita, Y., Kivimaki, M., Kooner, JS., Kumar, MJ., Kuh, D., Kulkarni, SR., Kumari, M., Kuusisto, J., Kuznetsova, T., Laakso, M., Laan, M., Laitinen, J., Lakatta, EG., Langefeld, CD., Larson, MG., Lathrop, M., Lawlor, DA., Lawrence, RW., Lee, JY., Lee, NR., Levy, D., Li, Y., Longstreth, WT., Luan£££Jian'an£££ J., Lucas, G., Ludwig, B., Mangino, M., Mani, KR., Marmot, MG., Mattace-Raso, FU., Matullo, G., McArdle, WL., McKenzie, CA., Meitinger, T., Melander, O., Meneton, P., Meschia, JF., Miki, T., Milaneschi, Y., Mohlke, KL., Mooser, V., Morken, MA., Morris, RW., Mosley, TH., Najjar, S., Narisu, N., Newton-Cheh, C., Nguyen, KD., Nilsson, P., Nyberg, F., O'Donnell, CJ., Ogihara, T., Ohkubo, T., Okamura, T., Ong, RT., Ongen, H., Onland-Moret, NC., O'Reilly, PF., Org, E., Orru, M., Palmas, W., Palmen, J., Palmer, LJ., Palmer, ND., Parker, AN., Peden, JF., Peltonen, L., Perola, M., Pihur, V., Platou, CG., Plump, A., Prabhakaran, D., Psaty, BM., Raffel, LJ., Rao, DC., Rasheed, A., Ricceri, F., Rice, KM., Rosengren, A., Rotter, JI., Rudock, ME., Sõber, S., Salako, T., Saleheen, D., Salomaa, V., Samani, NJ., Schwartz, SM., Schwarz, PE., Scott, LJ., Scott, J., Scuteri, A., Sehmi, JS., Seielstad, M., Seshadri, S., Sharma, P., Shaw-Hawkins, S., Shi, G., Shrine, NR., Sijbrands, EJ., Sim, X., Singleton, A., Sjögren, M., Smith, NL., Soler Artigas, M., Spector, TD., Staessen, JA., Stancakova, A., Steinle, NI., Strachan, DP., Stringham, HM., Sun, YV., Swift, AJ., Tabara, Y., Tai, ES., Talmud, PJ., Taylor, A., Terzic, J., Thelle, DS., Tobin, MD., Tomaszewski, M., Tripathy, V., Tuomilehto, J., Tzoulaki, I., Uda, M., Ueshima, H., Uiterwaal, CS., Umemura, S., van der Harst, P., van der Schouw YT., van Gilst WH., Vartiainen, E., Vasan, RS., Veldre, G., Verwoert, GC., Viigimaa, M., Vinay, DG., Vineis, P., Voight, BF., Vollenweider, P., Wagenknecht, LE., Wain, LV., Wang, X., Wang, TJ., Wareham, NJ., Watkins, H., Weder, AB., Whincup, PH., Wiggins, KL., Witteman, JC., Wong, A., Wu, Y., Yajnik, CS., Yao, J., Young, JH., Zelenika, D., Zhai, G., Zhang, W., Zhang, F., Zhao, JH., Zhu, H., Zhu, X., Zitting, P., Zukowska-Szczechowska, E., Okada, Y., Wu, JY., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, SC., Wong, TY., Liu, J., Young, TL., Aung, T., Teo, YY., Kim, YJ., Kang, D., Chen, CH., Tsai, FJ., Chang, LC., Fann, SJ., Mei, H., Hixson, JE., Chen, S., Katsuya, T., Isono, M., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, YT., Tanaka, T., Reilly, MP., Schunkert, H., Assimes, TL., Hall, A., Hengstenberg, C., König, IR., Laaksonen, R., McPherson, R., Thompson, JR., Thorsteinsdottir, U., Ziegler, A., Absher, D., Chen, L., Cupples, LA., Halperin, E., Li, M., Musunuru, K., Preuss, M., Schillert, A., Thorleifsson, G., Wells, GA., Holm, H., Roberts, R., Stewart, AF., Fortmann, S., Go, A., Hlatky, M., Iribarren, C., Knowles, J., Myers, R., Quertermous, T., Sidney, S., Risch, N., Tang, H., Blankenberg, S., Schnabel, R., Sinning, C., Lackner, KJ., Tiret, L., Nicaud, V., Cambien, F., Bickel, C., Rupprecht, HJ., Perret, C., Proust, C., Münzel, TF., Barbalic, M., Chen, IY., Demissie-Banjaw, S., Folsom, A., Lumley, T., Marciante, K., Taylor, KD., Volcik, K., Gretarsdottir, S., Gulcher, JR., Kong, A., Stefansson, K., Thorgeirsson, G., Andersen, K., Fischer, M., Grosshennig, A., Linsel-Nitschke, P., Stark, K., Schreiber, S., Aherrahrou, Z., Bruse, P., Doering, A., Klopp, N., Diemert, P., Loley, C., Medack, A., Nahrstedt, J., Peters, A., Wagner, AK., Willenborg, C., Böhm, BO., Dobnig, H., Grammer, TB., Hoffmann, MM., Meinitzer, A., Winkelmann, BR., Pilz, S., Renner, W., Scharnagl, H., Stojakovic, T., Tomaschitz, A., Winkler, K., Guiducci, C., Burtt, N., Gabriel, SB., Dandona, S., Jarinova, O., Qu, L., Wilensky, R., Matthai, W., Hakonarson, HH., Devaney, J., Burnett, MS., Pichard, AD., Kent, KM., Satler, L., Lindsay, JM., Waksman, R., Knouff, CW., Waterworth, DM., Walker, MC., Epstein, SE., Rader, DJ., Nelson, CP., Wright, BJ., Balmforth, AJ., Ball, SG., Loehr, LR., Rosamond, WD., Benjamin, E., Haritunians, T., Couper, D., Murabito, J., Wang, YA., Stricker, BH., Chang, PP., Willerson, JT., Felix, SB., Watzinger, N., Aragam, J., Zweiker, R., Lind, L., Rodeheffer, RJ., Greiser, KH., Deckers, JW., Stritzke, J., Ingelsson, E., Kullo, I., Haerting, J., Reffelmann, T., Redfield, MM., Werdan, K., Mitchell, GF., Arnett, DK., Gottdiener, JS., Blettner, M., Friedrich, N., Pattaro, C., Teumer, A., Gorski, M., Chu, A.Y., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M.H., Pers, T.H., Johnson, A.D., Ko, Y.A., Fuchsberger, C., Tayo, B., Nalls, M., Feitosa, M.F., Isaacs, A., Dehghan, A., d'Adamo, P., Adeyemo, A., Dieffenbach, A.K., Zonderman, A.B., Nolte, I.M., van der Most, P.J., Wright, A.F., Shuldiner, A.R., Morrison, A.C., Hofman, A., Smith, A.V., Dreisbach, A.W., Franke, A., Uitterlinden, A.G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B.I., Ponte, B., Oostra, B.A., Paulweber, B., Krämer, B.K., Mitchell, B.D., Buckley, B.M., Peralta, C.A., Hayward, C., Helmer, C., Rotimi, C.N., Shaffer, C.M., Müller, C., Sala, C., van Duijn, C.M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D.S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E.J., Holliday, E.G., Boerwinkle, E., Salvi, E., Bottinger, E.P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F.B., Navis, G.J., Curhan, G.C., Ehret, G.B., Homuth, G., Coassin, S., Thun, G.A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G.W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H.E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H.K., Kramer, H., Lin, H., Leach, I.M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I.M., Kolcic, I., Persico, I., Jukema, J.W., Wilson, J.F., Felix, J.F., Divers, J., Lambert, J.C., Stafford, J.M., Gaspoz, J.M., Smith, J.A., Faul, J.D., Wang, J.J., Ding, J., Hirschhorn, J.N., Attia, J., Whitfield, J.B., Chalmers, J., Viikari, J., Coresh, J., Denny, J.C., Karjalainen, J., Fernandes, J.K., Endlich, K., Butterbach, K., Keene, K.L., Lohman, K., Portas, L., Launer, L.J., Lyytikäinen, L.P., Yengo, L., Franke, L., Ferrucci, L., Rose, L.M., Kedenko, L., Rao, M., Struchalin, M., Kleber, M.E., Cavalieri, M., Haun, M., Cornelis, M.C., Ciullo, M., Pirastu, M., de Andrade, M., McEvoy, M.A., Woodward, M., Adam, M., Cocca, M., Nauck, M., Imboden, M., Waldenberger, M., Pruijm, M., Metzger, M., Stumvoll, M., Evans, M.K., Sale, M.M., Kähönen, M., Boban, M., Bochud, M., Rheinberger, M., Verweij, N., Bouatia-Naji, N., Martin, N.G., Hastie, N., Probst-Hensch, N., Soranzo, N., Devuyst, O., Raitakari, O., Gottesman, O., Franco, O.H., Polasek, O., Gasparini, P., Munroe, P.B., Ridker, P.M., Mitchell, P., Muntner, P., Meisinger, C., Smit, J.H., Kovacs, P., Wild, P.S., Froguel, P., Rettig, R., Mägi, R., Biffar, R., Schmidt, R., Middelberg, R.P., Carroll, R.J., Penninx, B.W., Scott, R.J., Katz, R., Sedaghat, S., Wild, S.H., Kardia, S.L., Ulivi, S., Hwang, S.J., Enroth, S., Kloiber, S., Trompet, S., Stengel, B., Hancock, S.J., Turner, S.T., Rosas, S.E., Stracke, S., Harris, T.B., Zeller, T., Zemunik, T., Lehtimäki, T., Illig, T., Aspelund, T., Nikopensius, T., Esko, T., Gyllensten, U., Völker, U., Emilsson, V., Vitart, V., Aalto, V., Gudnason, V., Chouraki, V., Chen, W.M., Igl, W., März, W., Koenig, W., Lieb, W., Loos, R.J., Liu, Y., Snieder, H., Pramstaller, P.P., Parsa, A., O'Connell, J.R., Susztak, K., Hamet, P., Tremblay, J., de Boer, I.H., Böger, C.A., Goessling, W., Chasman, D.I., Köttgen, A., Kao, W.H., and Fox, C.S.
Abstract: Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
Published: 2016

27. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

Author: Vimaleswaran, KS, Cavadino, A, Berry, DJ, Jorde, R, Dieffenbach, AK, Lu, C, Alves, AC, Heerspink, HJL, Tikkanen, E, Eriksson, J, Wong, A, Mangino, M, Jablonski, KA, Nolte, IM, Houston, DK, Ahluwalia, TS, Van der Most, PJ, Pasko, D, Zgaga, L, Thiering, E, Vitart, V, Fraser, RM, Huffman, JE, De Boer, RA, Schoettker, B, Saum, K-U, McCarthy, MI, Dupuis, J, Herzig, K-H, Sebert, S, Pouta, A, Laitinen, J, Kleber, ME, Navis, G, Lorentzon, M, Jameson, K, Arden, N, Cooper, JA, Acharya, J, Hardy, R, Raitakari, O, Ripatti, S, Billings, LK, Lahti, J, Osmond, C, Penninx, BW, Rejnmark, L, Lohman, KK, Paternoster, L, Stolk, RP, Hernandez, DG, Byberg, L, Hagstrom, E, Melhus, H, Ingelsson, E, Mellstroem, D, Ljunggren, O, Tzoulaki, I, McLachlan, S, Theodoratou, E, Tiesler, CMT, Jula, A, Navarro, P, Wright, AF, Polasek, O, Hayward, C, Wilson, JF, Rudan, I, Salomaa, V, Heinrich, J, Campbell, H, Price, JF, Karlsson, M, Lind, L, Michaesson, K, Bandinelli, S, Frayling, TM, Hartman, CA, Sorensen, TIA, Kritchevsky, SB, Langdahl, BL, Eriksson, JG, Florez, JC, Spector, TD, Lehtimaki, T, Kuh, D, Humphries, SE, Cooper, C, Ohlsson, C, Maerz, W, De Borst, MH, Kumari, M, Kivimaki, M, Wang, TJ, Power, C, Brenner, H, Grimnes, G, Van der Harst, P, Snieder, H, Hingorani, AD, Pilz, S, Whittaker, JC, Jarvelin, M-R, and Hypponen, E
Subjects: Adult, Male, Caroline Hayward, D SUPPLEMENTATION, Oxidoreductases Acting on CH-CH Group Donors, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, Polymorphism, Single Nucleotide, DISEASE, Body Mass Index, 1117 Public Health and Health Services, Endocrinology & Metabolism, KIDNEY, GENETIC-VARIANTS, Humans, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, Vitamin D, Cytochrome P450 Family 2, LifeLines Cohort Study investigators, Randomized Controlled Trials as Topic, OUTCOMES, Science & Technology, 1103 Clinical Sciences, Mendelian Randomization Analysis, Middle Aged, Vitamin D Deficiency, Phenotype, 1101 Medical Biochemistry and Metabolomics, Hypertension, Cholestanetriol 26-Monooxygenase, Global Blood Pressure Genetics (Global BPGen) consortium, TRIAL, Female, HEALTH, Life Sciences & Biomedicine, International Consortium for Blood Pressure (ICBP)
Abstract: Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk. Methods In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that affect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium. Findings In phenotypic analyses (up to n=49 363), increased 25(OH)D concentration was associated with decreased systolic blood pressure (β per 10% increase, −0·12 mm Hg, 95% CI −0·20 to −0·04; p=0·003) and reduced odds of hypertension (odds ratio [OR] 0·98, 95% CI 0·97–0·99; p=0·0003), but not with decreased diastolic blood pressure (β per 10% increase, −0·02 mm Hg, −0·08 to 0·03; p=0·37). In meta-analyses in which we combined data from D-CarDia and the ICBP (n=146 581, after exclusion of overlapping studies), each 25(OH)D-increasing allele of the synthesis score was associated with a change of −0·10 mm Hg in systolic blood pressure (−0·21 to −0·0001; p=0·0498) and a change of −0·08 mm Hg in diastolic blood pressure (−0·15 to −0·02; p=0·01). When D-CarDia and consortia data for hypertension were meta-analysed together (n=142 255), the synthesis score was associated with a reduced odds of hypertension (OR per allele, 0·98, 0·96–0·99; p=0·001). In instrumental variable analysis, each 10% increase in genetically instrumented 25(OH)D concentration was associated with a change of −0·29 mm Hg in diastolic blood pressure (−0·52 to −0·07; p=0·01), a change of −0·37 mm Hg in systolic blood pressure (−0·73 to 0·003; p=0·052), and an 8·1% decreased odds of hypertension (OR 0·92, 0·87–0·97; p=0·002). Interpretation Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension. This finding warrants further investigation in an independent, similarly powered study. Funding British Heart Foundation, UK Medical Research Council, and Academy of Finland.
Published: 2014

28. Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study

Author: Vimaleswaran, Kerani S., Cavadino, Alana, Berry, Diane J., Jorde, Rolf, Grimnes, Guri, Dieffenbach, Aida Karina, Lu, Chen, Alves, Alexessander Couto, Heerspink, Hiddo J. Lambers, Tikkanen, Emmi, Eriksson, Joel, Wong, Andrew, Mangino, Massimo, Jablonski, Kathleen A., Nolte, Ilja M., Houston, Denise K., Ahluwalia, Tarunveer Singh, van der Most, Peter J., Pasko, Dorota, Zgaga, Lina, Thiering, Elisabeth, Schöttker, B, Saum, KU, Brenner, H, Järvelin, MR, Tzoulaki, I, Snieder, H, Stolk, RP, Hartman, CA, de Boer, RA, van der Harst, P, Navis, G, de Borst, MH, Lorentzon, M, Mellström, D, Ohlsson, C, Hardy, R, Kuh, D, Cooper, JA, Acharya, J, Humphries, SE, Hingorani, AD, Kumari, M, Kivimaki, M, Spector, TD, Kritchevsky, SB, Lohman, KK, Sørensen, TIA, Frayling, TM, Campbell, H, Theodoratou, E, Fraser, RM, Wilson, JF, Rudan, I, Price, JF, McLachlan, S, Vitart, V, Navarro, P, Huffman, JE, Hayward, C, Wright, AF, Tiesler, CMT, Heinrich, J, McCarthy, MI, Ingelsson, E, Arden, N, Cooper, C, Dupuis, J, Herzig, KH, Sebert, S, Pouta, A, Laitinen, J, Kleber, ME, März, W, Jameson, K, Osmond, C, Raitakari, O, Ripatti, S, Lahti, J, Eriksson, JG, Penninx, BW, Billings, LK, Florez, JC, Rejnmark, L, Langdahl, BL, Paternoster, L, Hernandez, DG, Byberg, L, Michaelsson, K, Hagström, E, Melhus, H, Ljunggren, O, Lind, L, Jula, A, Polasek, O, Salomaa, V, Karlsson, M, Bandinelli, S, Lehtimäki, T, Wang, TJ, Pilz, S, and Whittaker, JC
Abstract: Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk. Methods In this mendelian randomisation study, we generated an allele score (25[OH]D synthesis score) based on variants of genes that aff ect 25(OH)D synthesis or substrate availability (CYP2R1 and DHCR7), which we used as a proxy for 25(OH)D concentration. We meta-analysed data for up to 108 173 individuals from 35 studies in the D-CarDia collaboration to investigate associations between the allele score and blood pressure measurements. We complemented these analyses with previously published summary statistics from the International Consortium on Blood Pressure (ICBP), the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, and the Global Blood Pressure Genetics (Global BPGen) consortium. Findings In phenotypic analyses (up to n=49 363), increased 25(OH)D concentration was associated with decreased systolic blood pressure (β per 10% increase, –0·12 mm Hg, 95% CI –0·20 to –0·04; p=0·003) and reduced odds of hypertension (odds ratio [OR] 0·98, 95% CI 0·97–0·99; p=0·0003), but not with decreased diastolic blood pressure (β per 10% increase, –0·02 mm Hg, –0·08 to 0·03; p=0·37). In meta-analyses in which we combined data from D-CarDia and the ICBP (n=146 581, after exclusion of overlapping studies), each 25(OH)D-increasing allele of the synthesis score was associated with a change of –0·10 mm Hg in systolic blood pressure (–0·21 to –0·0001; p=0·0498) and a change of –0·08 mm Hg in diastolic blood pressure (–0·15 to –0·02; p=0·01). When D-CarDia and consortia data for hypertension were meta-analysed together (n=142 255), the synthesis score was associated with a reduced odds of hypertension (OR per allele, 0·98, 0·96–0·99; p=0·001). In instrumental variable analysis, each 10% increase in genetically instrumented 25(OH)D concentration was associated with a change of –0·29 mm Hg in diastolic blood pressure (–0·52 to –0·07; p=0·01), a change of –0·37 mm Hg in systolic blood pressure (–0·73 to 0·003; p=0·052), and an 8·1% decreased odds of hypertension (OR 0·92, 0·87–0·97; p=0·002). Interpretation Increased plasma concentrations of 25(OH)D might reduce the risk of hypertension. This fi nding warrants further investigation in an independent, similarly powered study.
Published: 2014

29. Castability of Ti-6Al-7Nb alloy for dental casting

Author: Wang, TJ, Kobayashi, Equo, Doi, H, and Yoneyama, T
Published: 1999

30. New genetic loci link adipose and insulin biology to body fat distribution.

Author: ADIPOGen Consortium, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GEFOS Consortium, GENIE Consortium, International Endogene Consortium, LifeLines Cohort Study, MAGIC Investigators, MuTHER Consortium, PAGE Consortium, ReproGen Consortium, GLGC, ICBP, Dastani, Z., Hivert, MF., Timpson, N., Perry, JR., Yuan, X., Scott, RA., Henneman, P., Heid, IM., Kizer, JR., Lyytikainen, LP., Fuchsberger, C., Tanaka, T., Morris, AP., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S., Pankow, JS., Uh, HW., Wu, Y., Bidulescu, A., Rasmussen-Torvik, LJ., Greenwood, CM., Ladouceur, M., Grimsby, J., Manning, AK., Liu, CT., Kooner, J., Mooser, VE., Vollenweider, P., Kapur, KA., Chambers, J., Wareham, NJ., Langenberg, C., Frants, R., Willemsvan-vanDijk, K., Oostra, BA., Willems, SM., Lamina, C., Winkler, T., Psaty, BM., Tracy, RP., Brody, J., Chen, I., Viikari, J., Kähönen, M., Pramstaller, PP., Evans, DM., St Pourcain, B., Sattar, N., Wood, A., Bandinelli, S., Carlson, OD., Egan, JM., Böhringer, S., van Heemst, D., Kedenko, L., Kristiansson, K., Nuotio, ML., Loo, BM., Harris, T., Garcia, M., Kanaya, A., Haun, M., Klopp, N., Wichmann, HE., Deloukas, P., Katsareli, E., Couper, DJ., Duncan, BB., Kloppenburg, M., Adair, LS., Borja, JB., Wilson, JG., Musani, S., Guo, X., Johnson, T., Semple, R., Teslovich, TM., Allison, MA., Redline, S., Buxbaum, SG., Mohlke, KL., Meulenbelt, I., Ballantyne, CM., Dedoussis, GV., Hu, FB., Liu, Y., Paulweber, B., Spector, TD., Slagboom, P., Ferrucci, L., Jula, A., Perola, M., Raitakari, O., Florez, JC., Salomaa, V., Eriksson, JG., Frayling, TM., Hicks, AA., Lehtimäki, T., Smith, GD., Siscovick, DS., Kronenberg, F., van Duijn, C., Loos, RJ., Waterworth, DM., Meigs, JB., Dupuis, J., Richards, JB., Willenborg, C., Farrall, M., Assimes, TL., Thompson, JR., Ingelsson, E., Saleheen, D., Erdmann, J., Goldstein, BA., Stirrups, K., König, IR., Cazier, JB., Johansson£££Åsa£££ Å., Hall, AS., Lee, JY., Willer, CJ., 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K.L.
Abstract: Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Published: 2015

31. New genetic loci link adipose and insulin biology to body fat distribution

Author: Shungin, D, Winkler, T, Croteau Chonka, D, Ferreira, T, Locke, A, Mägi, R, Strawbridge, R, Pers, T, Fischer, K, Justice, A, Workalemahu, T, Wu, J, Buchkovich, M, Heard Costa, N, Roman, T, Drong, A, Song, C, Gustafsson, S, Day, F, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, J, Scherag, A, Vedantam, S, Wood, A, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, C, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg Gresham, J, Buyske, S, Demirkan, A, Ehret, G, Feitosa, M, Goel, A, Jackson, A, Johnson, T, Kleber, M, Kristiansson, K, Mangino, M, Leach, I, Medina Gomez, C, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Stanca'Kova', A, Sung, Y, Tanaka, T, Teumer, A, Van Vliet Ostaptchouk, J, Yengo, L, Zhang, W, Albrecht, E, Ärnlöv, J, Arscott, G, Bandinelli, S, Barrett, A, Bellis, C, Bennett, A, Berne, C, Blüher, M, Böhringer, S, Bonnet, F, Böttcher, Y, Bruinenberg, M, Carba, D, Caspersen, I, Clarke, R, Daw, E, Deelen, J, Deelman, E, Delgado, G, Doney, A, Eklund, N, Erdos, M, Estrada, K, Eury, E, Friedrich, N, Garcia, M, Giedraitis, V, Gigante, B, Go, A, Golay, A, Grallert, H, Grammer, T, Gräsler, J, Grewal, J, Groves, C, Haller, T, Hallmans, G, Hartman, C, Hassinen, M, Hayward, C, Heikkilä, K, Herzig, K, Helmer, Q, Hillege, H, Holmen, O, Hunt, S, Isaacs, A, Ittermann, T, James, A, Johansson, I, Juliusdottir, T, Kalafati, I, Kinnunen, L, Koenig, W, Kooner, I, Kratzer, W, Lamina, C, Leander, K, Lee, N, Lichtner, P, Lind, L, Lindström, J, Lobbens, S, Lorentzon, M, Mach, F, Magnusson, P, Mahajan, A, Mcardle, W, Menni, C, Merger, S, Mihailov, E, Milani, L, Mills, R, Moayyeri, A, Monda, K, Mooijaart, S, Mühleisen, T, Mulas, A, Müller, G, Müller Nurasyid, M, Nagaraja, R, Nalls, M, Narisu, N, Glorioso, N, Nolte, I, Olden, M, Rayner, N, Renstrom, F, Ried, J, Robertson, N, Rose, L, Sanna, S, Scharnagl, H, Scholtens, S, Sennblad, B, Seufferlein, T, Sitlani, C, Smith, A, Stirrups, K, Stringham, H, Sundström, J, Swertz, M, Swift, A, Syvänen, A, Tayo, B, Thorand, B, Thorleifsson, G, Tomaschitz, A, Troffa, C, Van Oort, F, Verweij, N, Vonk, J, Waite, L, Wennauer, R, Wilsgaard, T, Wojczynski, M, Wong, A, Zhang, Q, Zhao, J, Brennan, E, Choi, M, Eriksson, P, Folkersen, L, Franco Cereceda, A, Gharavi, A, Hedman, A, Hivert, M, Huang, J, Kanoni, S, Karpe, F, Keildson, S, Kiryluk, K, Liang, L, Lifton, R, Ma, B, Mcknight, A, Mcpherson, R, Metspalu, A, Min, J, Moffatt, M, Montgomery, G, Murabito, J, Nicholson, G, Nyholt, D, Olsson, C, Perry, J, Reinmaa, E, Salem, R, Sandholm, N, Schadt, E, Scott, R, Stolk, L, Vallejo, E, Westra, H, Zondervan, K, Amouyel, P, Arveiler, D, Bakker, S, Beilby, J, Bergman, R, Blangero, J, Brown, M, Burnier, M, Campbell, H, Chakravarti, A, Chines, P, Claudi Boehm, S, Collins, F, Crawford, D, Danesh, J, De Faire, U, De Geus, E, Dörr, M, Erbel, R, Eriksson, J, Farrall, M, Ferrannini, E, Ferrières, J, Forouhi, N, Forrester, T, Franco, O, Gansevoort, R, Gieger, C, Gudnason, V, Haiman, C, 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Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Wilson SG, Aalto V, Alen M, Aragaki AK, Center JR, Dailiana Z, Duggan DJ, Garcia Giralt N, Giroux S, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Svensson O, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Cheng S, Christiansen C, Cooper C, Frost M, Goltzman D, González Macías J, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Leslie WD, Lips P, Ljunggren Ö, Lorenc RS, Marc J, Mellström D, Obermayer Pietsch B, Olmos JM, Pettersson Kymmer U, Reid DM, Riancho JA, Ridker PM, Rousseau F, Slagboom PE, Tang NL, Urreizti R, Van Hul W, Zarrabeitia MT, Castano Betancourt M, Herrera L, Ingvarsson T, Johannsdottir H, Kwan T, Li R, Luben R, Medina Gómez C, Palsson ST, Reppe S, Sigurdsson G, van Meurs JB, Verlaan D, Williams FM, Wood AR, Zhou Y, Gautvik KM, Raychaudhuri S, Cauley JA, Clark GR, Cummings SR, Danoy P, Dennison EM, Eastell R, Eisman JA, Jackson RD, Jones G, Khaw KT, Lorentzon M, McCloskey E, Nandakumar K, Nicholson GC, Peacock M, Pols H, Prince RL, Reid IR, Robbins J, Sambrook PN, Sham PC, Tylavsky FA, Cupples LA, Econs MJ, Kung AW, Reeve J, Streeten EA, Zillikens MC, Ohlsson C, Karasik D, Brown MA, Ralston SH, Ioannidis JP, Kiel DP, Sandholm N, Salem RM, McKnight AJ, Brennan EP, Forsblom C, Isakova T, McKay GJ, Williams WW, Sadlier DM, Mäkinen VP, Swan EJ, Boright AP, Ahlqvist E, Deshmukh HA, Keller BJ, Huang H, Ahola A, Fagerholm E, Gordin D, Harjutsalo V, He B, Heikkilä O, Hietala K, Kytö J, Lahermo P, Lehto M, Österholm AM, Parkkonen M, Pitkäniemi J, Rosengård Bärlund M, Saraheimo M, Sarti C, Söderlund J, Soro Paavonen A, Syreeni A, Thorn LM, Tikkanen H, Tolonen N, Tryggvason K, Tuomilehto J, Wadén J, Gill GV, Prior S, Guiducci C, Mirel DB, Taylor A, Hosseini M, Parving HH, Rossing P, Tarnow L, Ladenvall C, Alhenc Gelas F, Lefebvre P, Rigalleau V, Roussel R, Tregouet DA, Maestroni A, Maestroni S, Falhammar H, Gu T, Möllsten A, Cimponeriu D, Mihai I, Mota M, Mota E, Serafinceanu C, Stavarachi M, Hanson RL, Nelson RG, Kretzler M, Colhoun HM, Panduru NM, Gu H, Brismar K, Zerbini G, Hadjadj S, Marre M, Lajer M, Waggott D, Savage DA, Bain SC, Martin F, Hirschhorn JN, Godson C, Groop PH, Maxwell AP, Schmidt EM, Sengupta S, Peloso GM, Ganna A, Chen J, Buchkovich ML, Mora S, Bragg Gresham JL, Chang HY, Den Hertog HM, Donnelly LA, Ehret GB, Feitosa MF, Ferreira T, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Jackson AU, Kaakinen M, Kettunen J, Li X, Magnusson PK, Mangino M, Montasser ME, Nolte IM, Palmer CD, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Sidore C, Surakka I, Van den Herik EG, Volcik KA, Wong A, Asiki G, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, CESANA, GIANCARLO, Elliott P, Eyjolfsson GI, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hartikainen AL, Hung YJ, Jones MR, Kaleebu P, Kastelein JJ, Kim E, Komulainen P, Kumari M, Lin SY, Lindström J, Mach F, McArdle WL, Müller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stančáková A, Swift AJ, Tiret L, van Pelt L, Vedantam S, Wainwright N, Wijmenga C, Willemsen G, Wilsgaard T, Young EH, Bennett F, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Chakravarti A, Chen YD, Collins FS, Cooper RS, Feranil AB, Freimer NB, Gieger C, Groop LC, Hingorani A, Hovingh G, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Järvelin MR, Kaprio J, Kesäniemi A, Kivimaki M, Koudstaal PJ, Krauss RM, Kuh D, Kyvik KO, Lakka TA, Lindgren CM, Martin NG, McKenzie CA, Meneton P, Moilanen L, Munroe PB, Njølstad I, Power C, Price JF, Rauramaa R, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Strachan DP, Tayo BO, Tremoli E, Uusitupa M, Whitfield JB, Wolffenbuttel BH, Ordovas JM, Rich SS, Abecasis GR, Abecasis G, Caulfield M, Chasman D, Ehret G, Johnson A, Johnson L, Larson M, Levy D, Munroe P, Newton Cheh C, O'Reilly P, Palmas W, Psaty B, Rice K, Smith A, Snider H, Tobin M, Van Duijn C, Verwoert G, Rice KM, Tobin MD, Verwoert GC, Pihur V, O'Reilly PF, Launer L, Aulchenko Y, Heath S, Sõber S, Arora P, Zhang F, Lucas G, Milaneschi Y, Parker AN, Fava C, Fox ER, Go MJ, Sjögren M, Vinay D, Alexander M, Tabara Y, Shaw Hawkins S, Whincup PH, Shi G, Tayo B, Seielstad M, Sim X, Nguyen KD, Matullo G, Gaunt TR, Onland Moret NC, Cooper MN, Platou CG, Org E, Hardy R, Dahgam S, Palmen J, Kuznetsova T, Uiterwaal CS, Adeyemo A, Ludwig B, Tomaszewski M, Tzoulaki I, Palmer ND, Chang YP, Steinle NI, Grobbee DE, Morrison AC, Najjar S, Hadley D, Brown MJ, Connell JM, Hingorani AD, Day IN, Lawlor DA, Beilby JP, Lawrence RW, Ongen H, Li Y, Young JH, Bis JC, Lee NR, Bolton JA, Chaturvedi N, Islam M, Jafar TH, Kulkarni SR, Grässler J, Howard P, Guarrera S, Ricceri F, Emilsson V, Plump A, Weder AB, Sun YV, Bergman RN, Scott LJ, Stringham HM, Peltonen L, Vartiainen E, Brand SM, Staessen JA, Wang TJ, Burton PR, Artigas MS, Dong Y, Snieder H, Wang X, Zhu H, Lohman KK, Rudock ME, Heckbert SR, Smith NL, Wiggins KL, Doumatey A, Shriner D, Veldre G, Viigimaa M, Kinra S, Prabhakaran D, Tripathy V, Langefeld CD, Rosengren A, Thelle DS, Corsi AM, Singleton A, Forrester T, Hilton G, Salako T, Iwai N, Kita Y, Ogihara T, Ohkubo T, Okamura T, Ueshima H, Umemura S, Eyheramendy S, Meitinger T, Cho YS, Kim HL, Scott J, Sehmi JS, Hedblad B, Nilsson P, Stanèáková A, Raffel LJ, Yao J, Schwartz SM, Ikram M, Longstreth W. Jr, Mosley TH, Seshadri S, Shrine NR, Wain LV, Morken MA, Laitinen J, Zitting P, Cooper JA, van Gilst WH, Janipalli CS, Mani K, Yajnik CS, Mattace Raso FU, Lakatta EG, Orru M, Scuteri A, Ala Korpela M, Kangas AJ, Soininen P, Tukiainen T, Würtz P, Ong RT, Dörr M, Galan P, Hercberg S, Lathrop M, Zelenika D, Zhai G, Meschia JF, Nalls MA, Sharma P, Terzic J, Kumar M, Denniff M, Zukowska Szczechowska E, Wagenknecht LE, Fowkes F, Charchar FJ, Rotimi C, Bots ML, Brand E, Talmud PJ, Nyberg F, Laan M, Palmer LJ, van der Schouw YT, Casas JP, Vineis P, Ganesh SK, Wong TY, Tai ES, Rao DC, Morris RW, Dominiczak AF, Marmot MG, Miki T, Chandak GR, Zhu X, Gyllensten UB, Elosua R, Soranzo N, Sijbrands EJ, Uda M, Vasan RS, Larson MG, Caulfield MJ, Anderson CA, Gordon S, Guo Q, Henders A, Lambert A, Kraft P, Kennedy SH, Macgregor S, Missmer SA, Montgomery GW, Nyholt DR, Painter JN, Roseman F, Treloar SA, Visscher PM, Wallace L, Zondervan KT, Alizadeh B, de Boer RA, Boezen HM, Bruinenberg M, Franke L, Hillege HL, van der Klauw MM, Ormel J, Postma DS, Rosmalen JG, Slaets JP, Stolk RP, Lagou V, Welch RP, Wheeler E, Rehnberg E, Yengo L, Lecoeur C, Johnson PC, Mahajan A, Verweij N, Hottenga JJ, Sennblad B, Salo P, Timpson NJ, Hui J, Bielak LF, Zhao W, Horikoshi M, Navarro P, Fall T, Chen H, Robertson N, Rybin D, Chines PS, Song K, An P, Marullo L, Jansen H, Oldehinkel AJ, North KE, Forouhi NG, Edkins S, Varga TV, Oksa H, Antonella M, Kong A, Herder C, Antti J, Miljkovic I, Atalay M, Kiess W, James AL, Smit JH, Campbell S, Fowkes GR, Basart HV, Rathmann W, Maerz W, Province MA, Watanabe RM, de Geus EJ, Penninx BW, Oostra B, Toenjes A, Peyser PA, Körner A, Keinanen Kiukaanniemi SM, Saaristo TE, Boomsma D, Cucca F, Balkau B, Froguel P, Jarvelin MR, Bouatia Naji N, Ahmadi KR, Ainali C, Barrett A, Bataille V, Bell JT, Buil A, Dermitzakis ET, Dimas AS, Durbin R, Glass D, Hassanali N, Hedman ÅK, Ingle C, Keildson S, Knowles D, Krestyaninova M, Lowe CE, Meduri E, di Meglio P, Min JL, Montgomery SB, Nestle FO, Nica AC, Nisbet J, O'Rahilly S, Parts L, Potter S, Sekowska M, Shin SY, Small KS, Surdulescu G, Travers ME, Tsaprouni L, Tsoka S, Wilk A, Matise T, Buyske S, Higashio J, Williams R, Nato A, Ambite JL, Deelman E, Manolio T, Hindorff L, Heiss G, Taylor K, Avery C, Graff M, Lin D, Quibrera M, Cochran B, Kao L, Umans J, Cole S, MacCluer J, Person S, Pankow J, Gross M, Fornage M, Durda P, Jenny N, Patsy B, Arnold A, Buzkova P, Crawford D, Haines J, Murdock D, Glenn K, Brown Gentry K, Thornton Wells T, Dumitrescu L, Jeff J, Bush WS, Mitchell SL, Goodloe R, Wilson S, Boston J, Malinowski J, Restrepo N, Oetjens M, Fowke J, Zheng W, Spencer K, Ritchie M, Pendergrass S, Le Marchand L, Wilkens L, Park L, Tiirikainen M, Kolonel L, Lim U, Cheng I, Wang H, Shohet R, Haiman C, Stram D, Henderson B, Monroe K, Schumacher F, Peters U, Anderson G, Carlson C, Prentice R, LaCroix A, Wu C, Carty C, Gong J, Rosse S, Young A, Haessler J, Kocarnik J, Lin Y, Jackson R, Duggan D, Kuller L, Stolk L, He C, Sulem P, Barbalic M, Broer L, Byrne EM, Gudbjartsson DF, McArdle PF, Porcu E, van Wingerden S, Zhuang W, Albrecht E, Alizadeh BZ, Lauc LB, Broekmans FJ, Burri A, Chanock SJ, Chen C, Corre T, Coviello AD, d'Adamo P, Davies G, Deary IJ, Ebrahim S, Fauser BC, Ferreli L, Folsom AR, Garcia ME, Hall P, Haller T, Hankinson SE, Hass M, Heath AC, Janssens AC, Keyzer J, Lahti J, Lai S, Laisk T, Laven JS, Liu J, Lopez LM, Louwers YV, Marongiu M, Klaric IM, Masciullo C, McKnight B, Medland SE, Melzer D, Newman AB, Paré G, Peeters PH, Plump AS, Pop VJ, Räikkönen K, Salumets A, Smith JA, Stacey SN, Starr JM, Stathopoulou MG, Tenesa A, Thorand B, Tryggvadottir L, Tsui K, van Dam RM, van Gils CH, van Nierop P, Vink JM, Voorhuis M, Wallaschofski H, Widen E, Wijnands van Gent CJ, Zgaga L, Zygmunt M, Arnold AM, Buring JE, Crisponi L, Demerath EW, Hunter DJ, Schlessinger D, Murray A, Murabito JM, Visser JA, Lunetta KL, Elks CE, Cousminer DL, Feenstra B, Lin P, van Wingerden SW, Smith EN, Warrington NM, Alavere H, Berenson GS, Blackburn H, Busonero F, Chen W, Couper D, Easton DF, Foroud T, Geller F, Hernandez DG, Kilpeläinen TO, Li S, Melbye M, Murray JC, Murray SS, Nelis M, Ness AR, Northstone K, Pennell CE, Pharoah P, Rafnar T, Rice JP, Ring SM, Schork NJ, Segrè AV, Sovio U, Srinivasan SR, Tammesoo ML, Tyrer J, Weedon MN, Wichmann H, Young L, Zhuang WV, Bierut LJ, Boyd HA, and Murray A.
Abstract: Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10-8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Published: 2015

32. Mechanical properties and corrosion resistance of Ti-6Al-7Nb alloy dental castings

Author: Kobayashi, Equo, Wang, TJ, Doi, H, Yoneyama, T, and Hamanaka, H
Published: 1998

33. Statin administration does not improve the mobilization of very small embryonic-like stem cells (VSELs) in contrast to resveratrol treatment in a murine model of acute myocardial infarction

Author: Hongbo Wang, Yuejin Yang, Li P, Gao Lj, Zhang Q, Wang Sd, Qian Hy, and Wang Tj
Subjects: Cardiac function curve, Male, medicine.medical_specialty, Statin, Physiology, medicine.drug_class, health care facilities, manpower, and services, Atorvastatin, Population, Myocardial Infarction, Mice, Cell Movement, Internal medicine, Cellular cardiomyoplasty, Stilbenes, medicine, Animals, cardiovascular diseases, Myocardial infarction, education, health care economics and organizations, Embryonic Stem Cells, education.field_of_study, business.industry, Anti-Inflammatory Agents, Non-Steroidal, General Medicine, medicine.disease, Combined Modality Therapy, Transplantation, Mice, Inbred C57BL, Treatment Outcome, Resveratrol, Cardiology, Physical therapy, Stem cell, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, medicine.drug, Stem Cell Transplantation
Abstract: We have found that short-term statin treatment plus stem cell transplantation in acutely infarcted hearts improves cardiac function because statins promote the efficacy of cellular cardiomyoplasty. Autologous Sca-1+Lin-CD45-(CXCR+) very small embryonic-like stem cell (VSEL) mobilization in acute myocardial infarction (AMI) correlates with the preservation of cardiac function. Whether short-term atorvastatin (Ator) can enhance the mobilization or recruitment of VSELs in AMI is still unclear. We divided mice into 4 groups: 1) sham; 2) AMI; 3) AMI+resveratrol (RSV) as a positive control; and 4) AMI+Ator. There was an increase in the circulating VSEL/full population of leukocytes (FPL) ratio 48 hours after AMI, and AMI+RSV increased it further. Ator administration did not increase the VSEL/FPL ratio. The cardiac stromal cell-derived factor-1 (SDF-1) and SDF-1α levels were in agreement with the results of VSEL mobilization. One week after AMI, more Sca-1+CXCR+ cells were recruited to the myocardium of AMI+RSV mice but not AMI+Ator mice. Short-term Ator administration failed to upregulate cardiac SDF-1 and could not enhance the recruitment of VSELs early after AMI.
Published: 2012

34. Development of Chemopreventive Strategies for Radiation-Induced Cancer: Targeting Radiation-Induced Genetic Alterations

Author: Alexandra C. Miller, Wang Tj, Ainsworth Ej, Thomas M. Seed, and Lui L
Subjects: Pathology, medicine.medical_specialty, Oncogene, Public Health, Environmental and Occupational Health, General Medicine, Cell cycle, Biology, medicine.disease_cause, medicine.disease, Leukemia, In vivo, medicine, Cancer research, Radiation-induced cancer, Signal transduction, Carcinogenesis, Carcinogen
Abstract: Carcinogenesis is a multistage process involving dysregulation of signal transduction and cell cycle pathways. This dysregulation results in specific molecular and genetic alterations, including gene amplification, mutations, and chromosomal rearrangements. These aberrations can be measured to provide a novel means to assess carcinogenic risk or as targets for chemointervention. Recent human and in vivo studies have demonstrated that genetic alterations, such as oncogenes and oncoproteins, were observed in preneoplastic tissues or serum following exposure to chemical carcinogens or low-level radiation (LLR). Identification of preneoplastic changes following radiation exposure may provide information that will allow development of LLR chemopreventive strategies. Radiation carcinogenesis studies in vivo with a lung tumor model showed that a low-dose cobalt-60 radiation exposure induced persistent time-dependent genetic alterations, such as elevated ras expression. This radiation exposure also resulted in lung tumor formation in 26% of the irradiated animals at 232 days after irradiation. A significant and progressive increase in ras oncogene expression was measured using Northern blot analysis in 80% of the irradiated animals over the duration of the experiment. Pharmacological intervention strategies are being tested using buthionine-[S,R]-sulfoximine (BSO). BSO has been previously shown to down-regulate ras expression. Administration of BSO prevented radiation-induced changes in ras mRNA levels in this lung tumor model. Further studies are being conducted with an LLR-induced leukemia model in which detection of circulating levels of oncoproteins will be more feasible. Based on these preliminary results and on its clinical efficacy and low clinical toxicity, BSO warrants further study as an LLR chemopreventive agent. Furthermore, this strategy to target LLR-induced preneoplastic alterations may be an effective means of developing modulators of LLR-induced cancers.
Published: 2002

35. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Author: Wain, LV, Verwoert, GC, O'Reilly, PF, Shi, G, Johnson, T, Johnson, AD, Bochud, M, Rice, KM, Henneman, P, Smith, AV, Ehret, GB, Amin, N, Larson, MG, Mooser, V, Hadley, D, Dörr, M, Bis, JC, Aspelund, T, Esko, T, Janssens, AC, Zhao, JH, Heath, S, Laan, M, Fu, J, Pistis, G, Luan, J, Arora, P, Lucas, G, Pirastu, N, Pichler, I, Jackson, AU, Webster, RJ, Zhang, F, Peden, JF, Schmidt, H, Tanaka, T, Campbell, H, Igl, W, Milaneschi, Y, Hottenga, JJ, Vitart, V, Chasman, DI, Trompet, S, Bragg-Gresham, JL, Alizadeh, BZ, Chambers, JC, Guo, X, Lehtimäki, T, Kühnel, B, Lopez, LM, Polašek, O, Boban, M, Nelson, CP, Morrison, AC, Pihur, V, Ganesh, SK, Hofman, A, Kundu, S, Mattace-Raso, FU, Rivadeneira, F, Sijbrands, EJ, Uitterlinden, AG, Hwang, SJ, Vasan, RS, Wang, TJ, Bergmann, S, Vollenweider, P, Waeber, G, Laitinen, J, Pouta, A, Zitting, P, McArdle, WL, Kroemer, HK, Völker, U, Völzke, H, Glazer, NL, Taylor, KD, Harris, TB, Alavere, H, Haller, T, Keis, A, Tammesoo, ML, Aulchenko, Y, Barroso, I, Khaw, KT, Galan, P, Hercberg, S, Lathrop, M, Eyheramendy, S, Org, E, Sõber, S, Lu, X, Nolte, IM, Penninx, BW, Corre, T, Masciullo, C, Sala, C, Groop, L, Voight, BF, Melander, O, O'Donnell, CJ, Salomaa, V, d'Adamo, AP, Fabretto, A, Faletra, F, Ulivi, S, Del Greco, F, Facheris, M, Collins, FS, Bergman, RN, Beilby, JP, Hung, J, Musk, AW, Mangino, M, Shin, SY, Soranzo, N, Watkins, H, Goel, A, Hamsten, A, Gider, P, Loitfelder, M, Zeginigg, M, Hernandez, D, Najjar, SS, Navarro, P, Wild, SH, Corsi, AM, Singleton, A, de Geus, EJ, Willemsen, G, Parker, AN, Rose, LM, Buckley, B, Stott, D, Orru, M, Uda, M, LifeLines Cohort Study, van der Klauw, MM, Zhang, W, Li, X, Scott, J, Chen, YD, Burke, GL, Kähönen, M, Viikari, J, Döring, A, Meitinger, T, Davies, G, Starr, JM, Emilsson, V, Plump, A, Lindeman, JH, Hoen, PA, König, IR, EchoGen consortium, Felix, JF, Clarke, R, Hopewell, JC, Ongen, H, Breteler, M, Debette, S, Destefano, AL, Fornage, M, AortaGen Consortium, Mitchell, GF, CHARGE Consortium Heart Failure Working Group, Smith, NL, KidneyGen consortium, Holm, H, Stefansson, K, Thorleifsson, G, Thorsteinsdottir, U, CKDGen consortium, Cardiogenics consortium, CardioGram, Samani, NJ, Preuss, M, Rudan, I, Hayward, C, Deary, IJ, Wichmann, HE, Raitakari, OT, Palmas, W, Kooner, JS, Stolk, RP, Jukema, JW, Wright, AF, Boomsma, DI, Bandinelli, S, Gyllensten, UB, Wilson, JF, Ferrucci, L, Schmidt, R, Farrall, M, Spector, TD, Palmer, LJ, Tuomilehto, J, Pfeufer, A, Gasparini, P, Siscovick, D, Altshuler, D, Loos, RJ, Toniolo, D, Snieder, H, Gieger, C, Meneton, P, Wareham, NJ, Oostra, BA, Metspalu, A, Launer, L, Rettig, R, Strachan, DP, Beckmann, JS, Witteman, JC, Erdmann, J, van Dijk, KW, Boerwinkle, E, Boehnke, M, Ridker, PM, Jarvelin, MR, Chakravarti, A, Abecasis, GR, Gudnason, V, Newton-Cheh, C, Levy, D, Munroe, PB, Psaty, BM, Caulfield, MJ, Rao, DC, Tobin, MD, Elliott, P, and van Duijn, CM
Published: 2011

36. Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

Author: Minelli, C, Vimaleswaran, KS, Berry, DJ, Lu, C, Tikkanen, E, Pilz, S, Hiraki, LT, Cooper, JD, Dastani, Z, Li, R, Houston, DK, Wood, AR, Michaelsson, K, Vandenput, L, Zgaga, L, Yerges-Armstrong, LM, McCarthy, MI, Dupuis, J, Kaakinen, M, Kleber, ME, Jameson, K, Arden, N, Raitakari, O, Viikari, J, Lohman, KK, Ferrucci, L, Melhus, H, Ingelsson, E, Byberg, L, Lind, L, Lorentzon, M, Salomaa, V, Campbell, H, Dunlop, M, Mitchell, BD, Herzig, K-H, Pouta, A, Hartikainen, A-L, Streeten, EA, Theodoratou, E, Jula, A, Wareham, NJ, Ohlsson, C, Frayling, TM, Kritchevsky, SB, Spector, TD, Richards, JB, Lehtimaki, T, Ouwehand, WH, Kraft, P, Cooper, C, Maerz, W, Power, C, Loos, RJF, Wang, TJ, Jaervelin, M-R, Whittaker, JC, Hingorani, AD, Hyppoenen, E, Minelli, C, Vimaleswaran, KS, Berry, DJ, Lu, C, Tikkanen, E, Pilz, S, Hiraki, LT, Cooper, JD, Dastani, Z, Li, R, Houston, DK, Wood, AR, Michaelsson, K, Vandenput, L, Zgaga, L, Yerges-Armstrong, LM, McCarthy, MI, Dupuis, J, Kaakinen, M, Kleber, ME, Jameson, K, Arden, N, Raitakari, O, Viikari, J, Lohman, KK, Ferrucci, L, Melhus, H, Ingelsson, E, Byberg, L, Lind, L, Lorentzon, M, Salomaa, V, Campbell, H, Dunlop, M, Mitchell, BD, Herzig, K-H, Pouta, A, Hartikainen, A-L, Streeten, EA, Theodoratou, E, Jula, A, Wareham, NJ, Ohlsson, C, Frayling, TM, Kritchevsky, SB, Spector, TD, Richards, JB, Lehtimaki, T, Ouwehand, WH, Kraft, P, Cooper, C, Maerz, W, Power, C, Loos, RJF, Wang, TJ, Jaervelin, M-R, Whittaker, JC, Hingorani, AD, and Hyppoenen, E
Abstract: BACKGROUND: Obesity is associated with vitamin D deficiency, and both are areas of active public health concern. We explored the causality and direction of the relationship between body mass index (BMI) and 25-hydroxyvitamin D [25(OH)D] using genetic markers as instrumental variables (IVs) in bi-directional Mendelian randomization (MR) analysis. METHODS AND FINDINGS: We used information from 21 adult cohorts (up to 42,024 participants) with 12 BMI-related SNPs (combined in an allelic score) to produce an instrument for BMI and four SNPs associated with 25(OH)D (combined in two allelic scores, separately for genes encoding its synthesis or metabolism) as an instrument for vitamin D. Regression estimates for the IVs (allele scores) were generated within-study and pooled by meta-analysis to generate summary effects. Associations between vitamin D scores and BMI were confirmed in the Genetic Investigation of Anthropometric Traits (GIANT) consortium (n = 123,864). Each 1 kg/m(2) higher BMI was associated with 1.15% lower 25(OH)D (p = 6.52×10⁻²⁷). The BMI allele score was associated both with BMI (p = 6.30×10⁻⁶²) and 25(OH)D (-0.06% [95% CI -0.10 to -0.02], p = 0.004) in the cohorts that underwent meta-analysis. The two vitamin D allele scores were strongly associated with 25(OH)D (p≤8.07×10⁻⁵⁷ for both scores) but not with BMI (synthesis score, p = 0.88; metabolism score, p = 0.08) in the meta-analysis. A 10% higher genetically instrumented BMI was associated with 4.2% lower 25(OH)D concentrations (IV ratio: -4.2 [95% CI -7.1 to -1.3], p = 0.005). No association was seen for genetically instrumented 25(OH)D with BMI, a finding that was confirmed using data from the GIANT consortium (p≥0.57 for both vitamin D scores). CONCLUSIONS: On the basis of a bi-directional genetic approach that limits confounding, our study suggests that a higher BMI leads to lower 25(OH)D, while any effects of lower 25(OH)D increasing BMI are likely to be small. Population level interventions to r
Published: 2013

37. Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium

Author: Fedorowski, A, Franceschini, N, Brody, J, Liu, CY, Verwoert, Germaine, Boerwinkle, E, Couper, D, Rice, KM, Rotter, JI, Mattace Raso, F.U.S., Uitterlinden, André, Hofman, Bert, Almgren, P, Sjogren, M, Hedblad, B, Larson, MG, Newton-Cheh, C, Wang, TJ, Rose, KM, Psaty, BM, Levy, D, Witteman, JCM, Melander, O, Fedorowski, A, Franceschini, N, Brody, J, Liu, CY, Verwoert, Germaine, Boerwinkle, E, Couper, D, Rice, KM, Rotter, JI, Mattace Raso, F.U.S., Uitterlinden, André, Hofman, Bert, Almgren, P, Sjogren, M, Hedblad, B, Larson, MG, Newton-Cheh, C, Wang, TJ, Rose, KM, Psaty, BM, Levy, D, Witteman, JCM, and Melander, O
Abstract: Orthostatic hypotension (OH), an independent predictor of mortality and cardiovascular events, strongly correlates with hypertension. Recent genome-wide studies have identified new loci influencing blood pressure (BP) in populations, but their impact on OH remains unknown. A total of 38 970 men and women of European ancestry from five population-based cohorts were included, of whom 2656 (6.8) met the diagnostic criteria for OH (systolic/diastolic BP drop epsilon 20/10 mmHg within 3 min of standing). Thirty-one recently discovered BP-associated single nucleotide polymorphisms (SNPs) were examined using an additive genetic model and the major allele as referent. Relations between OH, orthostatic systolic BP response, and genetic variants were assessed by inverse var The overall association between common gene variants in BP loci and OH was generally weak and the direction of effect inconsistent with resting BP findings. These results suggest that OH and resting BP share few genetic components.
Published: 2012

38. Pain relief after arthroscopic knee surgery: intravenous morphine, epidural morphine, and intra-articular morphine

Author: Wang Tj, Chiu-Ming Ho, Tang Js, Ho St, and Liaw Wj
Subjects: Male, medicine.medical_specialty, Knee Joint, Nausea, medicine.medical_treatment, Analgesic, Injections, Epidural, Injections, Intra-Articular, Route of administration, Arthroscopy, Diclofenac, Double-Blind Method, medicine, Humans, Prospective Studies, Chemotherapy, Pain, Postoperative, Morphine, business.industry, Urinary retention, Drug Administration Routes, Middle Aged, Surgery, Anesthesiology and Pain Medicine, Anesthesia, Injections, Intravenous, Vomiting, Female, Neurology (clinical), medicine.symptom, business, medicine.drug
Abstract: Objective: The aim of this study was to compare the analgesic efficacy and side effects of intravenous (IV), epidural, and intra-articular (IA) morphine after arthroscopic knee surgery. Design: Prospective, randomized, double-blind clinical investigation. Setting: Medical center, university teaching hospital. Patients: Inpatients with an American Society of Anesthesiologists physical status of I or II who were scheduled for elective arthroscopic knee surgery. Interventions and Outcome Measures: A total of 75 patients scheduled for arthroscopic knee surgery under epidural anesthesia were randomly divided into three groups (n = 25 in each group). At the end of surgery, patients in group I received 3 mg of IV morphine, patients in group 2 received 3 mg of epidural morphine, and patients in group 3 received 3 mg of IA morphine. Patients were then observed for 24 hours. During the observation period, the proportion of patients requiring rescue analgesia with intramuscular diclofenac in each group was calculated and the occurrence of morphine-related side effects was recorded. Results: We found that patients who received IV morphine requested more rescue analgesia than those who received either epidural or IA morphine. The proportions of patients requiring rescue analgesia in the IV, epidural, and IA groups were 65%, 13%, and 9%, respectively (p < 0.01 in group 1 vs. group 2 and in group 1 vs. group 3). Epidural morphine was associated with higher incidences of nausea and vomiting, pruritus, and urinary retention than IA morphine (range, p < 0.05-0.01 in group 2 vs. group 3). Conclusions: Patients who received IA morphine consumed less rescue analgesia than those who received IV morphine. They also reported fewer side effects than those patients who received epidural morphine. Intra-articular morphine may be the method of choice for pain relief after arthroscopic knee surgery.
Published: 2000

39. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Author: Ehret, GB, Munroe, PB, Rice, KM, Bochud, M, Johnson, AD, Chasman, DI, Smith, AV, Tobin, MD, Verwoert, GC, Hwang, S-J, Pihur, V, Vollenweider, P, O'Reilly, PF, Amin, N, Bragg-Gresham, JL, Teumer, A, Glazer, NL, Launer, L, Zhao, JH, Aulchenko, Y, Heath, S, Sober, S, Parsa, A, Luan, J, Arora, P, Dehghan, A, Zhang, F, Lucas, G, Hicks, AA, Jackson, AU, Peden, JF, Tanaka, T, Wild, SH, Rudan, I, Igl, W, Milaneschi, Y, Parker, AN, Fava, C, Chambers, JC, Fox, ER, Kumari, M, Go, MJ, van der Harst, P, Kao, WHL, Sjogren, M, Vinay, DG, Alexander, M, Tabara, Y, Shaw-Hawkins, S, Whincup, PH, Liu, Y, Shi, G, Kuusisto, J, Tayo, B, Seielstad, M, Sim, X, Khanh-Dung, HN, Lehtimaki, T, Matullo, G, Wu, Y, Gaunt, TR, Onland-Moret, NC, Cooper, MN, Platou, CGP, Org, E, Hardy, R, Dahgam, S, Palmen, J, Vitart, V, Braund, PS, Kuznetsova, T, Uiterwaal, CSPM, Adeyemo, A, Palmas, W, Campbell, H, Ludwig, B, Tomaszewski, M, Tzoulaki, I, Palmer, ND, Aspelund, T, Garcia, M, Chang, Y-PC, O'Connell, JR, Steinle, NI, Grobbee, DE, Arking, DE, Kardia, SL, Morrison, AC, Hernandez, D, Najjar, S, McArdle, WL, Hadley, D, Brown, MJ, Connell, JM, Hingorani, AD, Day, INM, Lawlor, DA, Beilby, JP, Lawrence, RW, Clarke, R, Hopewell, JC, Ongen, H, Dreisbach, AW, Li, Y, Young, JH, Bis, JC, Kahonen, M, Viikari, J, Adair, LS, Lee, NR, Chen, M-H, Olden, M, Pattaro, C, Bolton, JAH, Koettgen, A, Bergmann, S, Mooser, V, Chaturvedi, N, Frayling, TM, Islam, M, Jafar, TH, Erdmann, J, Kulkarni, SR, Bornstein, SR, Graessler, J, Groop, L, Voight, BF, Kettunen, J, Howard, P, Taylor, A, Guarrera, S, Ricceri, F, Emilsson, V, Plump, A, Barroso, IS, Khaw, K-T, Weder, AB, Hunt, SC, Sun, YV, Bergman, RN, Collins, FS, Bonnycastle, LL, Scott, LJ, Stringham, HM, Peltonen, L, Perola, M, Vartiainen, E, Brand, S-M, Staessen, JA, Wang, TJ, Burton, PR, Artigas, MS, Dong, Y, Snieder, H, Wang, X, Zhu, H, Lohman, KK, Rudock, ME, Heckbert, SR, Smith, NL, Wiggins, KL, Doumatey, A, Shriner, D, Veldre, G, Viigimaa, M, Kinra, S, Prabhakaran, D, Tripathy, V, Langefeld, CD, Rosengren, A, Thelle, DS, Corsi, AM, Singleton, A, Forrester, T, Hilton, G, McKenzie, CA, Salako, T, Iwai, N, Kita, Y, Ogihara, T, Ohkubo, T, Okamura, T, Ueshima, H, Umemura, S, Eyheramendy, S, Meitinger, T, Wichmann, H-E, Cho, YS, Kim, H-L, Lee, J-Y, Scott, J, Sehmi, JS, Zhang, W, Hedblad, B, Nilsson, P, Smith, GD, Wong, A, Narisu, N, Stancakova, A, Raffel, LJ, Yao, J, Kathiresan, S, O'Donnell, CJ, Schwartz, SM, Ikram, MA, Longstreth, WT, Mosley, TH, Seshadri, S, Shrine, NRG, Wain, LV, Morken, MA, Swift, AJ, Laitinen, J, Prokopenko, I, Zitting, P, Cooper, JA, Humphries, SE, Danesh, J, Rasheed, A, Goel, A, Hamsten, A, Watkins, H, Bakker, SJL, van Gilst, WH, Janipalli, CS, Mani, KR, Yajnik, CS, Hofman, A, Mattace-Raso, FUS, Oostra, BA, Demirkan, A, Isaacs, A, Rivadeneira, F, Lakatta, EG, Orru, M, Scuteri, A, Ala-Korpela, M, Kangas, AJ, Lyytikainen, L-P, Soininen, P, Tukiainen, T, Wurtz, P, Ong, RT-H, Doerr, M, Kroemer, HK, Voelker, U, Voelzke, H, Galan, P, Hercberg, S, Lathrop, M, Zelenika, D, Deloukas, P, Mangino, M, Spector, TD, Zhai, G, Meschia, JF, Nalls, MA, Sharma, P, Terzic, J, Kumar, MVK, Denniff, M, Zukowska-Szczechowska, E, Wagenknecht, LE, Fowkes, FGR, Charchar, FJ, Schwarz, PEH, Hayward, C, Guo, X, Rotimi, C, Bots, ML, Brand, E, Samani, NJ, Polasek, O, Talmud, PJ, Nyberg, F, Kuh, D, Laan, M, Hveem, K, Palmer, LJ, van der Schouw, YT, Casas, JP, Mohlke, KL, Vineis, P, Raitakari, O, Ganesh, SK, Wong, TY, Tai, ES, Cooper, RS, Laakso, M, Rao, DC, Harris, TB, Morris, RW, Dominiczak, AF, Kivimaki, M, Marmot, MG, Miki, T, Saleheen, D, Chandak, GR, Coresh, J, Navis, G, Salomaa, V, Han, B-G, Zhu, X, Kooner, JS, Melander, O, Ridker, PM, Bandinelli, S, Gyllensten, UB, Wright, AF, Wilson, JF, Ferrucci, L, Farrall, M, Tuomilehto, J, Pramstaller, PP, Elosua, R, Soranzo, N, Sijbrands, EJG, Altshuler, D, Loos, RJF, Shuldiner, AR, Gieger, C, Meneton, P, Uitterlinden, AG, Wareham, NJ, Gudnason, V, Rotter, JI, Rettig, R, Uda, M, Strachan, DP, Witteman, JCM, Hartikainen, A-L, Beckmann, JS, Boerwinkle, E, Vasan, RS, Boehnke, M, Larson, MG, Jarvelin, M-R, Psaty, BM, Abecasis, GR, Chakravarti, A, Elliott, P, van Duijn, CM, Newton-Cheh, C, Levy, D, Caulfield, MJ, Johnson, T, Ehret, GB, Munroe, PB, Rice, KM, Bochud, M, Johnson, AD, Chasman, DI, Smith, AV, Tobin, MD, Verwoert, GC, Hwang, S-J, Pihur, V, Vollenweider, P, O'Reilly, PF, Amin, N, Bragg-Gresham, JL, Teumer, A, Glazer, NL, Launer, L, Zhao, JH, Aulchenko, Y, Heath, S, Sober, S, Parsa, A, Luan, J, Arora, P, Dehghan, A, Zhang, F, Lucas, G, Hicks, AA, Jackson, AU, Peden, JF, Tanaka, T, Wild, SH, Rudan, I, Igl, W, Milaneschi, Y, Parker, AN, Fava, C, Chambers, JC, Fox, ER, Kumari, M, Go, MJ, van der Harst, P, Kao, WHL, Sjogren, M, Vinay, DG, Alexander, M, Tabara, Y, Shaw-Hawkins, S, Whincup, PH, Liu, Y, Shi, G, Kuusisto, J, Tayo, B, Seielstad, M, Sim, X, Khanh-Dung, HN, Lehtimaki, T, Matullo, G, Wu, Y, Gaunt, TR, Onland-Moret, NC, Cooper, MN, Platou, CGP, Org, E, Hardy, R, Dahgam, S, Palmen, J, Vitart, V, Braund, PS, Kuznetsova, T, Uiterwaal, CSPM, Adeyemo, A, Palmas, W, Campbell, H, Ludwig, B, Tomaszewski, M, Tzoulaki, I, Palmer, ND, Aspelund, T, Garcia, M, Chang, Y-PC, O'Connell, JR, Steinle, NI, Grobbee, DE, Arking, DE, Kardia, SL, Morrison, AC, Hernandez, D, Najjar, S, McArdle, WL, Hadley, D, Brown, MJ, Connell, JM, Hingorani, AD, Day, INM, Lawlor, DA, Beilby, JP, Lawrence, RW, Clarke, R, Hopewell, JC, Ongen, H, Dreisbach, AW, Li, Y, Young, JH, Bis, JC, Kahonen, M, Viikari, J, Adair, LS, Lee, NR, Chen, M-H, Olden, M, Pattaro, C, Bolton, JAH, Koettgen, A, Bergmann, S, Mooser, V, Chaturvedi, N, Frayling, TM, Islam, M, Jafar, TH, Erdmann, J, Kulkarni, SR, Bornstein, SR, Graessler, J, Groop, L, Voight, BF, Kettunen, J, Howard, P, Taylor, A, Guarrera, S, Ricceri, F, Emilsson, V, Plump, A, Barroso, IS, Khaw, K-T, Weder, AB, Hunt, SC, Sun, YV, Bergman, RN, Collins, FS, Bonnycastle, LL, Scott, LJ, Stringham, HM, Peltonen, L, Perola, M, Vartiainen, E, Brand, S-M, Staessen, JA, Wang, TJ, Burton, PR, Artigas, MS, Dong, Y, Snieder, H, Wang, X, Zhu, H, Lohman, KK, Rudock, ME, Heckbert, SR, Smith, NL, Wiggins, KL, Doumatey, A, Shriner, D, Veldre, G, Viigimaa, M, Kinra, S, Prabhakaran, D, Tripathy, V, Langefeld, CD, Rosengren, A, Thelle, DS, Corsi, AM, Singleton, A, Forrester, T, Hilton, G, McKenzie, CA, Salako, T, Iwai, N, Kita, Y, Ogihara, T, Ohkubo, T, Okamura, T, Ueshima, H, Umemura, S, Eyheramendy, S, Meitinger, T, Wichmann, H-E, Cho, YS, Kim, H-L, Lee, J-Y, Scott, J, Sehmi, JS, Zhang, W, Hedblad, B, Nilsson, P, Smith, GD, Wong, A, Narisu, N, Stancakova, A, Raffel, LJ, Yao, J, Kathiresan, S, O'Donnell, CJ, Schwartz, SM, Ikram, MA, Longstreth, WT, Mosley, TH, Seshadri, S, Shrine, NRG, Wain, LV, Morken, MA, Swift, AJ, Laitinen, J, Prokopenko, I, Zitting, P, Cooper, JA, Humphries, SE, Danesh, J, Rasheed, A, Goel, A, Hamsten, A, Watkins, H, Bakker, SJL, van Gilst, WH, Janipalli, CS, Mani, KR, Yajnik, CS, Hofman, A, Mattace-Raso, FUS, Oostra, BA, Demirkan, A, Isaacs, A, Rivadeneira, F, Lakatta, EG, Orru, M, Scuteri, A, Ala-Korpela, M, Kangas, AJ, Lyytikainen, L-P, Soininen, P, Tukiainen, T, Wurtz, P, Ong, RT-H, Doerr, M, Kroemer, HK, Voelker, U, Voelzke, H, Galan, P, Hercberg, S, Lathrop, M, Zelenika, D, Deloukas, P, Mangino, M, Spector, TD, Zhai, G, Meschia, JF, Nalls, MA, Sharma, P, Terzic, J, Kumar, MVK, Denniff, M, Zukowska-Szczechowska, E, Wagenknecht, LE, Fowkes, FGR, Charchar, FJ, Schwarz, PEH, Hayward, C, Guo, X, Rotimi, C, Bots, ML, Brand, E, Samani, NJ, Polasek, O, Talmud, PJ, Nyberg, F, Kuh, D, Laan, M, Hveem, K, Palmer, LJ, van der Schouw, YT, Casas, JP, Mohlke, KL, Vineis, P, Raitakari, O, Ganesh, SK, Wong, TY, Tai, ES, Cooper, RS, Laakso, M, Rao, DC, Harris, TB, Morris, RW, Dominiczak, AF, Kivimaki, M, Marmot, MG, Miki, T, Saleheen, D, Chandak, GR, Coresh, J, Navis, G, Salomaa, V, Han, B-G, Zhu, X, Kooner, JS, Melander, O, Ridker, PM, Bandinelli, S, Gyllensten, UB, Wright, AF, Wilson, JF, Ferrucci, L, Farrall, M, Tuomilehto, J, Pramstaller, PP, Elosua, R, Soranzo, N, Sijbrands, EJG, Altshuler, D, Loos, RJF, Shuldiner, AR, Gieger, C, Meneton, P, Uitterlinden, AG, Wareham, NJ, Gudnason, V, Rotter, JI, Rettig, R, Uda, M, Strachan, DP, Witteman, JCM, Hartikainen, A-L, Beckmann, JS, Boerwinkle, E, Vasan, RS, Boehnke, M, Larson, MG, Jarvelin, M-R, Psaty, BM, Abecasis, GR, Chakravarti, A, Elliott, P, van Duijn, CM, Newton-Cheh, C, Levy, D, Caulfield, MJ, and Johnson, T
Abstract: Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Published: 2011

40. A novel authentication method on edible bird nest by TripleQuad LC-MS/MS

Author: Chan, GKL, Li, J., Wang, SH, Wang, TJ, Dong, Tina Ting Xia, Tsim, Karl Wah Keung, Chan, GKL, Li, J., Wang, SH, Wang, TJ, Dong, Tina Ting Xia, and Tsim, Karl Wah Keung
Published: 2010

41. Fo Shou San, an ancient herbal decoction prepared from Angelica Sinensis Radix and Chuangxiong Rhizoma, stimulates the production of hemoglobin and erythropoietin in cultured cells

Author: Bi, CWC, Xie, HQ, Xu, SL, Li, Jun, Cheung, Wing Han, Zheng, KYZ, Lau, DTW, Choi, Chi Yan, Wang, TJ, Dong, Ting Xia, Tsim, Karl Wah Keung, Bi, CWC, Xie, HQ, Xu, SL, Li, Jun, Cheung, Wing Han, Zheng, KYZ, Lau, DTW, Choi, Chi Yan, Wang, TJ, Dong, Ting Xia, and Tsim, Karl Wah Keung
Published: 2010

42. Common genetic determinants of vitamin D insufficiency: A genome-wide association study

Author: Wang, TJ, Zhang, F, Richards, JB, Kestenbaum, B, Van Meurs, JB, Berry, D, Kiel, DP, Streeten, EA, Ohlsson, C, Koller, DL, Peltonen, L, Cooper, JD, O'Reilly, PF, Houston, DK, Glazer, NL, Vandenput, L, Peacock, M, Shi, J, Rivadeneira, F, McCarthy, MI, Anneli, P, De Boer, IH, Mangino, M, Kato, B, Smyth, DJ, Booth, SL, Jacques, PF, Burke, GL, Goodarzi, M, Cheung, CL, Wolf, M, Rice, K, Goltzman, D, Hidiroglou, N, Ladouceur, M, Wareham, NJ, Hocking, LJ, Hart, D, Arden, NK, Cooper, C, Malik, S, Fraser, WD, Hartikainen, AL, Zhai, G, Macdonald, HM, Forouhi, NG, Loos, RJF, Reid, DM, Hakim, A, Dennison, E, Liu, Y, Power, C, Stevens, HE, Jaana, L, Vasan, RS, Soranzo, N, Bojunga, J, Psaty, BM, Lorentzon, M, Foroud, T, Harris, TB, Hofman, A, Jansson, JO, Cauley, JA, Uitterlinden, AG, Gibson, Q, Järvelin, MR, Karasik, D, Siscovick, DS, Econs, MJ, Kritchevsky, SB, Florez, JC, Todd, JA, Dupuis, J, Hyppönen, E, Spector, TD, Wang, TJ, Zhang, F, Richards, JB, Kestenbaum, B, Van Meurs, JB, Berry, D, Kiel, DP, Streeten, EA, Ohlsson, C, Koller, DL, Peltonen, L, Cooper, JD, O'Reilly, PF, Houston, DK, Glazer, NL, Vandenput, L, Peacock, M, Shi, J, Rivadeneira, F, McCarthy, MI, Anneli, P, De Boer, IH, Mangino, M, Kato, B, Smyth, DJ, Booth, SL, Jacques, PF, Burke, GL, Goodarzi, M, Cheung, CL, Wolf, M, Rice, K, Goltzman, D, Hidiroglou, N, Ladouceur, M, Wareham, NJ, Hocking, LJ, Hart, D, Arden, NK, Cooper, C, Malik, S, Fraser, WD, Hartikainen, AL, Zhai, G, Macdonald, HM, Forouhi, NG, Loos, RJF, Reid, DM, Hakim, A, Dennison, E, Liu, Y, Power, C, Stevens, HE, Jaana, L, Vasan, RS, Soranzo, N, Bojunga, J, Psaty, BM, Lorentzon, M, Foroud, T, Harris, TB, Hofman, A, Jansson, JO, Cauley, JA, Uitterlinden, AG, Gibson, Q, Järvelin, MR, Karasik, D, Siscovick, DS, Econs, MJ, Kritchevsky, SB, Florez, JC, Todd, JA, Dupuis, J, Hyppönen, E, and Spector, TD
Abstract: Background Vitamin D is crucial for maintenance of musculoskeletal health, and might also have a role in extraskeletal tissues. Determinants of circulating 25-hydroxyvitamin D concentrations include sun exposure and diet, but high heritability suggests that genetic factors could also play a part. We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency. Methods We undertook a genome-wide association study of 25-hydroxyvitamin D concentrations in 33 996 individuals of European descent from 15 cohorts. Five epidemiological cohorts were designated as discovery cohorts (n=16 125), five as in-silico replication cohorts (n=9367), and five as de-novo replication cohorts (n=8504). 25-hydroxyvitamin D concentrations were measured by radioimmunoassay, chemiluminescent assay, ELISA, or mass spectrometry. Vitamin D insufficiency was defined as concentrations lower than 75 nmol/L or 50 nmol/L. We combined results of genome-wide analyses across cohorts using Z-score-weighted meta-analysis. Genotype scores were constructed for confirmed variants. Findings Variants at three loci reached genome-wide significance in discovery cohorts for association with 25-hydroxyvitamin D concentrations, and were confirmed in replication cohorts: 4p12 (overall p=1·9×10-109 for rs2282679, in GC); 11q12 (p=2·1×10-27 for rs12785878, near DHCR7); and 11p15 (p=3·3×10-20 for rs10741657, near CYP2R1). Variants at an additional locus (20q13, CYP24A1) were genome-wide significant in the pooled sample (p=6·0×10-10 for rs6013897). Participants with a genotype score (combining the three confirmed variants) in the highest quartile were at increased risk of having 25-hydroxyvitamin D concentrations lower than 75 nmol/L (OR 2·47, 95% CI 2·20-2·78, p= 2·3×10-48) or lower than 50 nmol/L (1·92, 1·70-2·16, p=1·0×10-26) compared with those in the lowest quartile. Interpretation Variants near genes involved in cholesterol synthesis, hydroxylation, and vitamin D transport
Published: 2010

43. Clinical and echocardiographic correlates of plasma procollagen type III amino-terminal peptide levels in the community

Author: Wang, TJ, Larsson, MG, Benjamin, EJ, Siwik, DA, Safa, R, Guo, CY, Corey, D, Sundström, Johan, Sawyer, DB, Colucci, WS, Vasan, RS, Wang, TJ, Larsson, MG, Benjamin, EJ, Siwik, DA, Safa, R, Guo, CY, Corey, D, Sundström, Johan, Sawyer, DB, Colucci, WS, and Vasan, RS
Abstract: Background Left ventricular remodeling is characterized by increased collagen deposition in the extracellular matrix. Levels of plasma procollagen type III amino-terminal peptide (PIIINP), a marker of collagen turnover, are elevated in the setting of recent myocardial infarction, heart failure, and cardiomyopathy. Whether plasma PIIINP levels are a useful indicator of subclinical left ventricular abnormalities in ambulatory individuals has not been studied. Methods We examined 967 Framingham Heart Study participants (mean age, 56 years; 60% women) who underwent routine echocardiography and measurement of plasma PIIINP levels. All participants were free of prior myocardial infarction or heart failure. Multivariable regression analyses were performed to examine the clinical and echocardiographic correlates of PIIINP levels. Results Plasma PIIINP levels increased with age and body mass index but did not significantly correlate with other cardiovascular risk factors including hypertension and diabetes. In multivariable models, there was no association between plasma PIIINP levels and left ventricular mass (P = .89), left ventricular fractional shortening (P = .15), left ventricular end-diastolic dimension (P = .51), or left atrial size (P = .68). Plasma PIIINP levels were positively correlated with tissue inhibitor of metalloproteinase-1 levels (multivariable-adjusted, P = .001). Conclusions The use of biomarkers of extracellular matrix turnover has generated recent interest, with plasma PIIINP being the most commonly studied biomarker in acute settings. However, our findings in a large, community-based cohort suggest that plasma PIIINP has limited use for the detection of structural heart disease in ambulatory individuals.
Published: 2007
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44. On the variability and correlation of surface ozone and carbon monoxide observed in Hong Kong using trajectory and regression analyses

Author: Wang, TJ, Lam, KS, Tsang, CW, Kot, SC, Wang, TJ, Lam, KS, Tsang, CW, and Kot, SC
Abstract: This paper investigates, the variability and correlation of surface ozone (03) and carbon monoxide (CO) observed at Cape D'Aguilar in Hong Kong from 1 January 1994 to 31 December 1995. Statistical analysis shows that the average O-3 and CO mixing ratios during the two years are 32+/-17 ppbv and 305+/-191 ppbv, respectively. The O-3/CO ratio ranges from 0.05 to 0.6 ppbv/ppbv with its frequency peaking at 0.15. The raw dataset is divided into six groups using backward trajectory and cluster analyses. For data assigned to the same trajectory type, three groups are further sorted out based on CO and NOx mixing ratios. The correlation coefficients and slopes of O-3/CO for the 18 groups are calculated using linear regression analysis. Finally, five kinds of air masses with different chemical features are identified: continental background (CB), marine background (MB), regional polluted continental (RPC), perturbed marine (P{*}M), and local polluted (LP) air masses. Further studies indicate that O-3 and CO in the continental and marine background air masses (CB and MB) are positively correlated for the reason that they are well mixed over the long range transport before arriving at the site. The negative correlation between O-3 and CO in air mass LP is believed to be associated with heavy anthropogenic influence, which results from the enhancement by local sources as indicated by high CO and NOx and depletion of O-3 when mixed with fresh emissions. The positive correlation in the perturbed marine air mass P{*}M favors the low photochemical production of O-3. The negative correlation found in the regional polluted continental air mass RPC is different from the observations at Oki Island in Japan due to the more complex O-3 chemistry at Cape D'Aguilar.
Published: 2004

45. Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study.

Author: Khan AM, Lubitz SA, Sullivan LM, Sun JX, Levy D, Vasan RS, Magnani JW, Ellinor PT, Benjamin EJ, Wang TJ, Khan, Abigail May, Lubitz, Steven A, Sullivan, Lisa M, Sun, Jenny X, Levy, Daniel, Vasan, Ramachandran S, Magnani, Jared W, Ellinor, Patrick T, Benjamin, Emelia J, and Wang, Thomas J
Published: 2013
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46. Association of plasma B-type natriuretic peptide concentrations with longitudinal blood pressure tracking in African Americans: findings from the Jackson Heart Study.

Author: Fox ER, Musani SK, Singh P, Bidulescu A, Nagarajarao HS, Samdarshi TE, Steffes MW, Wang TJ, Taylor HA, Vasan RS, Fox, Ervin R, Musani, Solomon K, Singh, Preeti, Bidulescu, Aurelian, Nagarajarao, Harsha S, Samdarshi, Tandaw E, Steffes, Michael W, Wang, Thomas J, Taylor, Herman A, and Vasan, Ramachandran S
Abstract: Water and sodium retention precedes the development of high blood pressure (BP) and explains a compensatory rise in B-type natriuretic peptide (BNP) concentrations. It is unclear whether BNP concentrations antedate the BP progression. We hypothesized that higher BNP concentrations in our African American cohort will be associated with longitudinal increases in BP, progression of BP stage, and incident hypertension. Our study sample consisted of 888 normotensive (based on BP at examination 1 [2000-2004]) participants of the Jackson Heart Study (mean age, 47±12 years; 61% women). We examined the relation of BNP concentrations at the baseline examination to change in systolic and diastolic BPs, BP progression (an increase by 1 BP stage as defined by THE sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure) and incident hypertension by examination 2 (2005-2008) adjusting for baseline BP stages, systolic and diastolic BPS, traditional risk factors, and echocardiographic left ventricular mass. Over a median follow-up period of 5.0±0.8 years, 36.9% progressed to a higher BP stage and 19.3% developed hypertension. In multivariable regression models, higher log-BNP concentrations at examination 1 were significantly and positively associated with changes in systolic and diastolic BPs (P<0.05 for both). Baseline log-BNP was significantly associated with BP progression (P=0.046). Every SD increase in baseline log BNP was associated with a 12% increased risk of BP progression. Log-BNP was not significantly associated with incident hypertension (P=0.12). In our community-based sample of African Americans, higher BNP concentrations predicted a longitudinal increase in systolic and diastolic BPs and progression of BP stage. [ABSTRACT FROM AUTHOR]
Published: 2013
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47. Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study.

Author: Wang TJ, Wollert KC, Larson MG, Coglianese E, McCabe EL, Cheng S, Ho JE, Fradley MG, Ghorbani A, Xanthakis V, Kempf T, Benjamin EJ, Levy D, Vasan RS, Januzzi JL, Wang, Thomas J, Wollert, Kai C, Larson, Martin G, Coglianese, Erin, and McCabe, Elizabeth L
Abstract: Background: Biomarkers for predicting cardiovascular events in community-based populations have not consistently added information to standard risk factors. A limitation of many previously studied biomarkers is their lack of cardiovascular specificity.Methods and Results: To determine the prognostic value of 3 novel biomarkers induced by cardiovascular stress, we measured soluble ST2, growth differentiation factor-15, and high-sensitivity troponin I in 3428 participants (mean age, 59 years; 53% women) in the Framingham Heart Study. We performed multivariable-adjusted proportional hazards models to assess the individual and combined ability of the biomarkers to predict adverse outcomes. We also constructed a "multimarker" score composed of the 3 biomarkers in addition to B-type natriuretic peptide and high-sensitivity C-reactive protein. During a mean follow-up of 11.3 years, there were 488 deaths, 336 major cardiovascular events, 162 heart failure events, and 142 coronary events. In multivariable-adjusted models, the 3 new biomarkers were associated with each end point (P<0.001) except coronary events. Individuals with multimarker scores in the highest quartile had a 3-fold risk of death (adjusted hazard ratio, 3.2; 95% confidence interval, 2.2-4.7; P<0.001), 6-fold risk of heart failure (6.2; 95% confidence interval, 2.6-14.8; P<0.001), and 2-fold risk of cardiovascular events (1.9; 95% confidence interval, 1.3-2.7; P=0.001). Addition of the multimarker score to clinical variables led to significant increases in the c statistic (P=0.005 or lower) and net reclassification improvement (P=0.001 or lower).Conclusion: Multiple biomarkers of cardiovascular stress are detectable in ambulatory individuals and add prognostic value to standard risk factors for predicting death, overall cardiovascular events, and heart failure. [ABSTRACT FROM AUTHOR]
Published: 2012
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48. Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study.

Author: Pikula A, Beiser AS, Decarli C, Himali JJ, Debette S, Au R, Selhub J, Toffler GH, Wang TJ, Meigs JB, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S, Pikula, Aleksandra, Beiser, Alexa S, DeCarli, Charles, Himali, Jayandra J, and Debette, Stephanie
Published: 2012
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49. Increased risk of anterior uveitis following herpes zoster: a nationwide population-based study.

Author: Wang TJ, Hu CC, and Lin HC
Published: 2012

50. Early repolarization pattern in competitive athletes: clinical correlates and the effects of exercise training.

Author: Noseworthy PA, Weiner R, Kim J, Keelara V, Wang F, Berkstresser B, Wood MJ, Wang TJ, Picard MH, Hutter AM Jr, Newton-Cheh C, Baggish AL, Noseworthy, Peter A, Weiner, Rory, Kim, Jonathan, Keelara, Varsha, Wang, Francis, Berkstresser, Brant, Wood, Malissa J, and Wang, Thomas J
Subjects: ARRHYTHMIA, ATHLETES, CARDIAC arrest, CARDIOVASCULAR system physiology, ELECTROCARDIOGRAPHY, EXERCISE physiology, LONGITUDINAL method, MULTIVARIATE analysis, RESEARCH funding, DISEASE prevalence, CROSS-sectional method
Abstract: Background: Inferior lead early repolarization pattern (ERP) recently has been associated with sudden cardiac death. Although ERP is common among athletes, prevalence, ECG lead distribution, clinical characteristics, and effects of physical training remain uncertain. We sought to examine the nonanterior ERP in competitive athletes.Methods and Results: ERP was assessed in a cross-sectional cohort of collegiate athletes (n = 879). The relationship between ERP and cardiac structure were then examined in a longitudinal subgroup (n = 146) before and after a 90-day period of exercise training. ERP was defined as J-point elevation ≥ 0.1 mV in at least 2 leads within a nonanterior territory (inferior [II, III, aVF] or lateral territory [I, aVL, V4-V6]). Nonanterior ERP was present in 25.1% (221/879) of athletes, including the inferior subtype in 3.8% (33/879). Exercise training led to significant increases in the prevalence of ERP and the inferior subtype, but there were no associations between ERP and echocardiographic measures of left ventricular remodeling. In a multivariable model, ERP was associated with black race (odds ratio [OR], 5.84; 95% CI, 3.54 to 9.61; P < 0.001), increased QRS voltage (OR, 2.08; 95% CI, 1.71 to 2.52; P < 0.001), and slower heart rate (OR, 1.54; 95% CI, 1.26 to 1.87; P < 0.001).Conclusions: Nonanterior ERP, including the inferior subtype, is common and has strong clinical associations among competitive athletes. The finding of increased ERP prevalence after intense physical training establishes a strong association between exercise and ERP. [ABSTRACT FROM AUTHOR]
Published: 2011
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