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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Authors :
Ehret, GB Munroe, PB Rice, KM Bochud, M Johnson, AD Chasman, DI Smith, AV Tobin, MD Verwoert, GC Hwang, S-J Pihur, V Vollenweider, P O'Reilly, PF Amin, N Bragg-Gresham, JL Teumer, A Glazer, NL Launer, L Zhao, JH Aulchenko, Y Heath, S Sober, S Parsa, A Luan, J Arora, P Dehghan, A Zhang, F Lucas, G Hicks, AA Jackson, AU Peden, JF Tanaka, T Wild, SH Rudan, I Igl, W Milaneschi, Y Parker, AN Fava, C Chambers, JC Fox, ER Kumari, M Go, MJ van der Harst, P Kao, WHL Sjogren, M Vinay, DG Alexander, M Tabara, Y Shaw-Hawkins, S Whincup, PH Liu, Y Shi, G Kuusisto, J Tayo, B Seielstad, M Sim, X Khanh-Dung, HN Lehtimaki, T Matullo, G Wu, Y Gaunt, TR Onland-Moret, NC Cooper, MN Platou, CGP Org, E Hardy, R Dahgam, S Palmen, J Vitart, V Braund, PS Kuznetsova, T Uiterwaal, CSPM Adeyemo, A Palmas, W Campbell, H Ludwig, B Tomaszewski, M Tzoulaki, I Palmer, ND Aspelund, T Garcia, M Chang, Y-PC O'Connell, JR Steinle, NI Grobbee, DE Arking, DE Kardia, SL Morrison, AC Hernandez, D Najjar, S McArdle, WL Hadley, D Brown, MJ Connell, JM Hingorani, AD Day, INM Lawlor, DA Beilby, JP Lawrence, RW Clarke, R Hopewell, JC Ongen, H Dreisbach, AW Li, Y Young, JH Bis, JC Kahonen, M Viikari, J Adair, LS Lee, NR Chen, M-H Olden, M Pattaro, C Bolton, JAH Koettgen, A Bergmann, S Mooser, V Chaturvedi, N Frayling, TM Islam, M Jafar, TH Erdmann, J Kulkarni, SR Bornstein, SR Graessler, J Groop, L Voight, BF Kettunen, J Howard, P Taylor, A Guarrera, S Ricceri, F Emilsson, V Plump, A Barroso, IS Khaw, K-T Weder, AB Hunt, SC Sun, YV Bergman, RN Collins, FS Bonnycastle, LL Scott, LJ Stringham, HM Peltonen, L Perola, M Vartiainen, E Brand, S-M Staessen, JA Wang, TJ Burton, PR Artigas, MS Dong, Y Snieder, H Wang, X Zhu, H Lohman, KK Rudock, ME Heckbert, SR Smith, NL Wiggins, KL Doumatey, A Shriner, D Veldre, G Viigimaa, M Kinra, S Prabhakaran, D Tripathy, V Langefeld, CD Rosengren, A Thelle, DS Corsi, AM Singleton, A Forrester, T Hilton, G McKenzie, CA Salako, T Iwai, N Kita, Y Ogihara, T Ohkubo, T Okamura, T Ueshima, H Umemura, S Eyheramendy, S Meitinger, T Wichmann, H-E Cho, YS Kim, H-L Lee, J-Y Scott, J Sehmi, JS Zhang, W Hedblad, B Nilsson, P Smith, GD Wong, A Narisu, N Stancakova, A Raffel, LJ Yao, J Kathiresan, S O'Donnell, CJ Schwartz, SM Ikram, MA Longstreth, WT Mosley, TH Seshadri, S Shrine, NRG Wain, LV Morken, MA Swift, AJ Laitinen, J Prokopenko, I Zitting, P Cooper, JA Humphries, SE Danesh, J Rasheed, A Goel, A Hamsten, A Watkins, H Bakker, SJL van Gilst, WH Janipalli, CS Mani, KR Yajnik, CS Hofman, A Mattace-Raso, FUS Oostra, BA Demirkan, A Isaacs, A Rivadeneira, F Lakatta, EG Orru, M Scuteri, A Ala-Korpela, M Kangas, AJ Lyytikainen, L-P Soininen, P Tukiainen, T Wurtz, P Ong, RT-H Doerr, M Kroemer, HK Voelker, U Voelzke, H Galan, P Hercberg, S Lathrop, M Zelenika, D Deloukas, P Mangino, M Spector, TD Zhai, G Meschia, JF Nalls, MA Sharma, P Terzic, J Kumar, MVK Denniff, M Zukowska-Szczechowska, E Wagenknecht, LE Fowkes, FGR Charchar, FJ Schwarz, PEH Hayward, C Guo, X Rotimi, C Bots, ML Brand, E Samani, NJ Polasek, O Talmud, PJ Nyberg, F Kuh, D Laan, M Hveem, K Palmer, LJ van der Schouw, YT Casas, JP Mohlke, KL Vineis, P Raitakari, O Ganesh, SK Wong, TY Tai, ES Cooper, RS Laakso, M Rao, DC Harris, TB Morris, RW Dominiczak, AF Kivimaki, M Marmot, MG Miki, T Saleheen, D Chandak, GR Coresh, J Navis, G Salomaa, V Han, B-G Zhu, X Kooner, JS Melander, O Ridker, PM Bandinelli, S Gyllensten, UB Wright, AF Wilson, JF Ferrucci, L Farrall, M Tuomilehto, J Pramstaller, PP Elosua, R Soranzo, N Sijbrands, EJG Altshuler, D Loos, RJF Shuldiner, AR Gieger, C Meneton, P Uitterlinden, AG Wareham, NJ Gudnason, V Rotter, JI Rettig, R Uda, M Strachan, DP Witteman, JCM Hartikainen, A-L Beckmann, JS Boerwinkle, E Vasan, RS Boehnke, M Larson, MG Jarvelin, M-R Psaty, BM Abecasis, GR Chakravarti, A Elliott, P van Duijn, CM Newton-Cheh, C Levy, D Caulfield, MJ Johnson, T Ehret, GB Munroe, PB Rice, KM Bochud, M Johnson, AD Chasman, DI Smith, AV Tobin, MD Verwoert, GC Hwang, S-J Pihur, V Vollenweider, P O'Reilly, PF Amin, N Bragg-Gresham, JL Teumer, A Glazer, NL Launer, L Zhao, JH Aulchenko, Y Heath, S Sober, S Parsa, A Luan, J Arora, P Dehghan, A Zhang, F Lucas, G Hicks, AA Jackson, AU Peden, JF Tanaka, T Wild, SH Rudan, I Igl, W Milaneschi, Y Parker, AN Fava, C Chambers, JC Fox, ER Kumari, M Go, MJ van der Harst, P Kao, WHL Sjogren, M Vinay, DG Alexander, M Tabara, Y Shaw-Hawkins, S Whincup, PH Liu, Y Shi, G Kuusisto, J Tayo, B Seielstad, M Sim, X Khanh-Dung, HN Lehtimaki, T Matullo, G Wu, Y Gaunt, TR Onland-Moret, NC Cooper, MN Platou, CGP Org, E Hardy, R Dahgam, S Palmen, J Vitart, V Braund, PS Kuznetsova, T Uiterwaal, CSPM Adeyemo, A Palmas, W Campbell, H Ludwig, B Tomaszewski, M Tzoulaki, I Palmer, ND Aspelund, T Garcia, M Chang, Y-PC O'Connell, JR Steinle, NI Grobbee, DE Arking, DE Kardia, SL Morrison, AC Hernandez, D Najjar, S McArdle, WL Hadley, D Brown, MJ Connell, JM Hingorani, AD Day, INM Lawlor, DA Beilby, JP Lawrence, RW Clarke, R Hopewell, JC Ongen, H Dreisbach, AW Li, Y Young, JH Bis, JC Kahonen, M Viikari, J Adair, LS Lee, NR Chen, M-H Olden, M Pattaro, C Bolton, JAH Koettgen, A Bergmann, S Mooser, V Chaturvedi, N Frayling, TM Islam, M Jafar, TH Erdmann, J Kulkarni, SR Bornstein, SR Graessler, J Groop, L Voight, BF Kettunen, J Howard, P Taylor, A Guarrera, S Ricceri, F Emilsson, V Plump, A Barroso, IS Khaw, K-T Weder, AB Hunt, SC Sun, YV Bergman, RN Collins, FS Bonnycastle, LL Scott, LJ Stringham, HM Peltonen, L Perola, M Vartiainen, E Brand, S-M Staessen, JA Wang, TJ Burton, PR Artigas, MS Dong, Y Snieder, H Wang, X Zhu, H Lohman, KK Rudock, ME Heckbert, SR Smith, NL Wiggins, KL Doumatey, A Shriner, D Veldre, G Viigimaa, M Kinra, S Prabhakaran, D Tripathy, V Langefeld, CD Rosengren, A Thelle, DS Corsi, AM Singleton, A Forrester, T Hilton, G McKenzie, CA Salako, T Iwai, N Kita, Y Ogihara, T Ohkubo, T Okamura, T Ueshima, H Umemura, S Eyheramendy, S Meitinger, T Wichmann, H-E Cho, YS Kim, H-L Lee, J-Y Scott, J Sehmi, JS Zhang, W Hedblad, B Nilsson, P Smith, GD Wong, A Narisu, N Stancakova, A Raffel, LJ Yao, J Kathiresan, S O'Donnell, CJ Schwartz, SM Ikram, MA Longstreth, WT Mosley, TH Seshadri, S Shrine, NRG Wain, LV Morken, MA Swift, AJ Laitinen, J Prokopenko, I Zitting, P Cooper, JA Humphries, SE Danesh, J Rasheed, A Goel, A Hamsten, A Watkins, H Bakker, SJL van Gilst, WH Janipalli, CS Mani, KR Yajnik, CS Hofman, A Mattace-Raso, FUS Oostra, BA Demirkan, A Isaacs, A Rivadeneira, F Lakatta, EG Orru, M Scuteri, A Ala-Korpela, M Kangas, AJ Lyytikainen, L-P Soininen, P Tukiainen, T Wurtz, P Ong, RT-H Doerr, M Kroemer, HK Voelker, U Voelzke, H Galan, P Hercberg, S Lathrop, M Zelenika, D Deloukas, P Mangino, M Spector, TD Zhai, G Meschia, JF Nalls, MA Sharma, P Terzic, J Kumar, MVK Denniff, M Zukowska-Szczechowska, E Wagenknecht, LE Fowkes, FGR Charchar, FJ Schwarz, PEH Hayward, C Guo, X Rotimi, C Bots, ML Brand, E Samani, NJ Polasek, O Talmud, PJ Nyberg, F Kuh, D Laan, M Hveem, K Palmer, LJ van der Schouw, YT Casas, JP Mohlke, KL Vineis, P Raitakari, O Ganesh, SK Wong, TY Tai, ES Cooper, RS Laakso, M Rao, DC Harris, TB Morris, RW Dominiczak, AF Kivimaki, M Marmot, MG Miki, T Saleheen, D Chandak, GR Coresh, J Navis, G Salomaa, V Han, B-G Zhu, X Kooner, JS Melander, O Ridker, PM Bandinelli, S Gyllensten, UB Wright, AF Wilson, JF Ferrucci, L Farrall, M Tuomilehto, J Pramstaller, PP Elosua, R Soranzo, N Sijbrands, EJG Altshuler, D Loos, RJF Shuldiner, AR Gieger, C Meneton, P Uitterlinden, AG Wareham, NJ Gudnason, V Rotter, JI Rettig, R Uda, M Strachan, DP Witteman, JCM Hartikainen, A-L Beckmann, JS Boerwinkle, E Vasan, RS Boehnke, M Larson, MG Jarvelin, M-R Psaty, BM Abecasis, GR Chakravarti, A Elliott, P van Duijn, CM Newton-Cheh, C Levy, D Caulfield, MJ Johnson, T
Publication Year :
2011
Abstract
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Details
Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1315687538
Document Type :
Electronic Resource