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Your search keyword '"Walsch, Rosa D. Bailey"' showing total 5 results
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5 results on '"Walsch, Rosa D. Bailey"'

1. Preparation of 4-anilino-6-aryl-2H-pyran-2-ones from trilithiated acetoacetanilides and aromatic esters

Author

Downs, Jennifer R., Grant, Sally P., Townsend, Jessica D., Schady, Deborah A., Pastine, Stefan J., Embree, Mildred C., Metz, Clyde R., Pennington, William T., Walsch, Rosa D. Bailey, and Beam, Charles F.

Subjects
Anti-infective agents -- Analysis, Protease inhibitors -- Analysis, Antipyretics -- Analysis, Acetanilide -- Analysis, Rearrangements (Chemistry) -- Analysis
Abstract

Acetoacetanilide and 4'-chloroacetoacetanilide were trilithiated with excess lithium diisopropylamide and condensed with several aromatic esters, followed by neutralization, separate acid cyclization, and rearrangements. After C-acylation of trilithiated acetoacetanilides and cyclization to 4H-pyran-4-ones, these compounds underwent multistep rearrangements to 4-anilino-6-aryl-2H-pyran-2-ones. Key words: pyranones, trianions, Claisen-type condensations, rearrangements.

Published
2004

2. The C-Acylation of Trilithiated Acetoacetanilides Followed by Cyclization and Rearrangements to 3-Aryl-5-Aminoaryl-2H-Pyran-2-Ones

Author

Downs, Jennifer R., Grant, Sally P., Townsend, Jessica D., Pastine, Stefan J., Embree, Mildred C., Metz, Clyde R., Walsch, Rosa D. Bailey, Pennington, William T., and Beam, Charles F.

Subjects
Chemical research -- Analysis, Science and technology, Analysis
Abstract

The initially perceived routine condensation of trilithiated acetoacetanilides with several benzoate esters did not give the anticipated C-acylated or cyclized 4-pyranone product. A 2-pyranone resulting from several rearrangements of the [...]

Published
2001

3. Preparation of substituted 1,2‐Dihydro‐3H‐pyrazol‐3‐ones from polylithiated 2′‐phenylphenylacetohydrazides and aromatic esters

Author

Downs, Jennifer R., primary, Pastine, Stefan J., additional, Townsend, Jessica D., additional, Greer, Heather A., additional, Kelley, Wayne, additional, Schady, Deborah A., additional, Mcconaughy, Teresa Lentz, additional, Metz, Clyde R., additional, Beam, Charles F., additional, Almquist, Catharine D., additional, Pennington, William T., additional, and Walsch, Rosa D. Bailey, additional

Published
2001
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5. Preparation of substituted 1,2Dihydro3Hpyrazol3ones from polylithiated 2′phenylphenylacetohydrazides and aromatic esters

Author

Downs, Jennifer R., Pastine, Stefan J., Townsend, Jessica D., Greer, Heather A., Kelley, Wayne, Schady, Deborah A., Mcconaughy, Teresa Lentz, Metz, Clyde R., Beam, Charles F., Almquist, Catharine D., Pennington, William T., and Walsch, Rosa D. Bailey

Abstract

Several 2′phenylphenylacetohydrazides were polylithiated with excess lithium diisopropylamide, and the resulting intermediates were condensed with several aromatic esters to afford Cacylated intermediates that were not usually isolated, but acid cyclized directly to 1,4,5trisubstituted, 1,2dihydro3Hpyrazol3ones.

Published
2001
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