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1. Inhibition of protein phosphatase 2A activity by selective electrophile alkylation damage

Author

Codreanu, Simona G., Adams, Deanna G., Dawson, Eric S., Wadzinsky, Brian E., and Liebler, Daniel C.

Subjects
Alkylation -- Analysis, Immunoblotting -- Usage, Phosphatases -- Chemical properties, Phosphorylation -- Analysis, Biological sciences, Chemistry
Abstract

The ability of alkylating electrophiles to inhibit protein phosphatases is examined, applying model electrophile probes that exhibit chemistries relevant to diverse biological reactive intermediates. The identification of specific sites linked to protein phosphatase 2A (PP2A) inactivation suggests that specific assays for abducted forms of these sequences could provide a general means of screening PP2A inhibitors.

Published
2006

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