Search

Your search keyword '"Virtanen, Jyrki K [0000-0002-0648-999X]"' showing total 2 results
Start Over Author "Virtanen, Jyrki K [0000-0002-0648-999X]"
2 results on '"Virtanen, Jyrki K [0000-0002-0648-999X]"'

1. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Author

Luc Djoussé, Graham G. Giles, Maria Lankinen, Cécilia Samieri, Linda Snetselaar, Bruce M. Psaty, Toshiharu Ninomiya, Renata Micha, Yoichiro Hirakawa, Vilmundur Gudnason, Joan Lindsay, Allison M. Hodge, Lyn M. Steffen, Leanne K. Küpers, Jyrki K. Virtanen, Kay-Tee Khaw, Frank Qian, Mackenzie K Senn, Federica Laguzzi, Michael Y. Tsai, Qi Sun, Catherine Helmer, Ingeborg A. Brouwer, Yangbo Sun, Matti Marklund, Wendy Post, William S. Harris, Andres V. Ardisson Korat, Julie K. Bassett, Danielle Laurin, Pierre-Hugues Carmichael, David S. Siscovick, Jennifer G. Robinson, Yun-yu Chen, Johanna M. Geleijnse, Ulf Risérus, Alexis C. Wood, Rebecca D. Jackson, Nicholas J. Wareham, Aleix Sala-Vila, Jaako Mursu, Rachel A. Murphy, Markku Laakso, Jason H Y Wu, Dariush Mozaffarian, Rozenn N. Lemaitre, Nathan L. Tintle, Gudny Eiriksdottir, Fumiaki Imamura, Kuo-Liong Chien, Karin Leander, Nita G. Forouhi, Fatty Acids, Aladdin H. Shadyab, Frank B. Hu, Peilin Shi, Heidi Lai, Tintle, Nathan L [0000-0003-1447-9107], Imamura, Fumiaki [0000-0002-6841-8396], Virtanen, Jyrki K [0000-0002-0648-999X], Forouhi, Nita G [0000-0002-5041-248X], Geleijnse, Johanna M [0000-0001-7638-0589], Giles, Graham G [0000-0003-4946-9099], Gudnason, Vilmundur [0000-0001-5696-0084], Hodge, Allison [0000-0001-5464-2197], Laakso, Markku [0000-0002-3394-7749], Wareham, Nicholas J [0000-0003-1422-2993], Sun, Qi [0000-0002-8480-1563], Lemaitre, Rozenn N [0000-0002-7038-1844], Mozaffarian, Dariush [0000-0001-7958-9492], Apollo - University of Cambridge Repository, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Tintle, Nathan L. [0000-0003-1447-9107], Virtanen, Jyrki K. [0000-0002-0648-999X], Forouhi, Nita G. [0000-0002-5041-248X], Geleijnse, Johanna M. [0000-0001-7638-0589], Giles, Graham G. [0000-0003-4946-9099], Wareham, Nicholas J. [0000-0003-1422-2993], Lemaitre, Rozenn N. [0000-0002-7038-1844], Health Sciences, APH - Health Behaviors & Chronic Diseases, and APH - Mental Health

Subjects
Male, Nutrition and Disease, 49/47, General Physics and Astronomy, Physiology, Disease, 030204 cardiovascular system & hematology, 0302 clinical medicine, Risk Factors, Cause of Death, Voeding en Ziekte, Medicine, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, ALL-CAUSE MORTALITY, Cause of death, RISK, chemistry.chemical_classification, Aged, 80 and over, Multidisciplinary, Public Health, Global Health, Social Medicine and Epidemiology, ASSOCIATION, Middle Aged, LONG-CHAIN OMEGA-3-FATTY-ACIDS, 3. Good health, Multidisciplinary Sciences, ADIPOSE-TISSUE, CARDIOVASCULAR-DISEASE, Docosahexaenoic acid, Meta-analysis, Science & Technology - Other Topics, Female, 692/499, Polyunsaturated fatty acid, Science, BIOMARKERS, Predictive markers, Lower risk, Fatty Acids and Outcomes Research Consortium (FORCE), Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, 692/53/2423, Fatty Acids, Omega-3, Life Science, Humans, CORONARY-HEART-DISEASE, SDG 14 - Life Below Water, Aged, VLAG, Science & Technology, business.industry, Mortality, Premature, Fatty acid, General Chemistry, DOCOSAHEXAENOIC ACID, Protective Factors, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, chemistry, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, FISH CONSUMPTION, business, Follow-Up Studies
Abstract

The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p, Associations between of omega-3 fatty acids and mortality are not clear. Here the authors report that, based on a pooled analysis of 17 prospective cohort studies, higher blood omega-3 fatty acid levels correlate with lower risk of all-cause mortality.

Published
2021

2. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

Author

Qian, Frank, Ardisson Korat, Andres V, Imamura, Fumiaki, Marklund, Matti, Tintle, Nathan, Virtanen, Jyrki K, Zhou, Xia, Bassett, Julie K, Lai, Heidi, Hirakawa, Yoichiro, Chien, Kuo-Liong, Wood, Alexis C, Lankinen, Maria, Murphy, Rachel A, Samieri, Cecilia, Pertiwi, Kamalita, De Mello, Vanessa D, Guan, Weihua, Forouhi, Nita G, Wareham, Nick, Hu, InterAct Consortium Frank B, Riserus, Ulf, Lind, Lars, Harris, William S, Shadyab, Aladdin H, Robinson, Jennifer G, Steffen, Lyn M, Hodge, Allison, Giles, Graham G, Ninomiya, Toshiharu, Uusitupa, Matti, Tuomilehto, Jaakko, Lindström, Jaana, Laakso, Markku, Siscovick, David S, Helmer, Catherine, Geleijnse, Johanna M, Wu, Jason HY, Fretts, Amanda, Lemaitre, Rozenn N, Micha, Renata, Mozaffarian, Dariush, Sun, Qi, Fatty Acids And Outcomes Research Consortium (FORCE), Qian, Frank [0000-0002-5579-3410], Virtanen, Jyrki K [0000-0002-0648-999X], Hirakawa, Yoichiro [0000-0002-4405-4399], Pertiwi, Kamalita [0000-0003-2861-9051], de Mello, Vanessa D [0000-0003-3414-6983], Forouhi, Nita G [0000-0002-5041-248X], Ninomiya, Toshiharu [0000-0003-1345-9032], Laakso, Markku [0000-0002-3394-7749], Lemaitre, Rozenn N [0000-0002-7038-1844], Sun, Qi [0000-0002-8480-1563], and Apollo - University of Cambridge Repository

Subjects
Cohort Studies, Diabetes Mellitus, Type 2, Docosahexaenoic Acids, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Humans, Prospective Studies, Biomarkers
Abstract

OBJECTIVE: Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS: For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis. RESULTS: A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSIONS: Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results