1. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
- Author
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Luc Djoussé, Graham G. Giles, Maria Lankinen, Cécilia Samieri, Linda Snetselaar, Bruce M. Psaty, Toshiharu Ninomiya, Renata Micha, Yoichiro Hirakawa, Vilmundur Gudnason, Joan Lindsay, Allison M. Hodge, Lyn M. Steffen, Leanne K. Küpers, Jyrki K. Virtanen, Kay-Tee Khaw, Frank Qian, Mackenzie K Senn, Federica Laguzzi, Michael Y. Tsai, Qi Sun, Catherine Helmer, Ingeborg A. Brouwer, Yangbo Sun, Matti Marklund, Wendy Post, William S. Harris, Andres V. Ardisson Korat, Julie K. Bassett, Danielle Laurin, Pierre-Hugues Carmichael, David S. Siscovick, Jennifer G. Robinson, Yun-yu Chen, Johanna M. Geleijnse, Ulf Risérus, Alexis C. Wood, Rebecca D. Jackson, Nicholas J. Wareham, Aleix Sala-Vila, Jaako Mursu, Rachel A. Murphy, Markku Laakso, Jason H Y Wu, Dariush Mozaffarian, Rozenn N. Lemaitre, Nathan L. Tintle, Gudny Eiriksdottir, Fumiaki Imamura, Kuo-Liong Chien, Karin Leander, Nita G. Forouhi, Fatty Acids, Aladdin H. Shadyab, Frank B. Hu, Peilin Shi, Heidi Lai, Tintle, Nathan L [0000-0003-1447-9107], Imamura, Fumiaki [0000-0002-6841-8396], Virtanen, Jyrki K [0000-0002-0648-999X], Forouhi, Nita G [0000-0002-5041-248X], Geleijnse, Johanna M [0000-0001-7638-0589], Giles, Graham G [0000-0003-4946-9099], Gudnason, Vilmundur [0000-0001-5696-0084], Hodge, Allison [0000-0001-5464-2197], Laakso, Markku [0000-0002-3394-7749], Wareham, Nicholas J [0000-0003-1422-2993], Sun, Qi [0000-0002-8480-1563], Lemaitre, Rozenn N [0000-0002-7038-1844], Mozaffarian, Dariush [0000-0001-7958-9492], Apollo - University of Cambridge Repository, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Tintle, Nathan L. [0000-0003-1447-9107], Virtanen, Jyrki K. [0000-0002-0648-999X], Forouhi, Nita G. [0000-0002-5041-248X], Geleijnse, Johanna M. [0000-0001-7638-0589], Giles, Graham G. [0000-0003-4946-9099], Wareham, Nicholas J. [0000-0003-1422-2993], Lemaitre, Rozenn N. [0000-0002-7038-1844], Health Sciences, APH - Health Behaviors & Chronic Diseases, and APH - Mental Health
- Subjects
Male ,Nutrition and Disease ,49/47 ,General Physics and Astronomy ,Physiology ,Disease ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Risk Factors ,Cause of Death ,Voeding en Ziekte ,Medicine ,030212 general & internal medicine ,Prospective Studies ,Prospective cohort study ,ALL-CAUSE MORTALITY ,Cause of death ,RISK ,chemistry.chemical_classification ,Aged, 80 and over ,Multidisciplinary ,Public Health, Global Health, Social Medicine and Epidemiology ,ASSOCIATION ,Middle Aged ,LONG-CHAIN OMEGA-3-FATTY-ACIDS ,3. Good health ,Multidisciplinary Sciences ,ADIPOSE-TISSUE ,CARDIOVASCULAR-DISEASE ,Docosahexaenoic acid ,Meta-analysis ,Science & Technology - Other Topics ,Female ,692/499 ,Polyunsaturated fatty acid ,Science ,BIOMARKERS ,Predictive markers ,Lower risk ,Fatty Acids and Outcomes Research Consortium (FORCE) ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,SDG 3 - Good Health and Well-being ,692/53/2423 ,Fatty Acids, Omega-3 ,Life Science ,Humans ,CORONARY-HEART-DISEASE ,SDG 14 - Life Below Water ,Aged ,VLAG ,Science & Technology ,business.industry ,Mortality, Premature ,Fatty acid ,General Chemistry ,DOCOSAHEXAENOIC ACID ,Protective Factors ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,chemistry ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,FISH CONSUMPTION ,business ,Follow-Up Studies - Abstract
The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15–18%, at least p, Associations between of omega-3 fatty acids and mortality are not clear. Here the authors report that, based on a pooled analysis of 17 prospective cohort studies, higher blood omega-3 fatty acid levels correlate with lower risk of all-cause mortality.
- Published
- 2021