5 results on '"Violeta Raverdi"'
Search Results
2. THU-297-Prediction of NAFLD progression according to duration of exposure to obesity and diabetes: New approach to adapt therapeutic and research strategies
- Author
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Alexandre Louvet, François Pattou, Philippe Mathurin, Viviane Gnemmi, Pierre Bauvin, Caiazzo Robert, Violeta Raverdi, Flavien Dautrecque, Line Carolle Ntandja Wandji, Lassailly Guillaume, Sylvie Deuffic-Burban, and Claire Delacôte
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Pediatrics ,medicine.medical_specialty ,Hepatology ,business.industry ,Research strategies ,Diabetes mellitus ,medicine ,Duration (project management) ,medicine.disease ,business ,Obesity - Published
- 2019
3. Human adipose tissue macrophages display activation of cancer-related pathways.: ATM link obesity and cancer?
- Author
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John Brozek, Robert Caiazzo, Alberto Mantovani, Gael Bories, Bruno Derudas, Marie Pigeyre, Giulia Chinetti-Gbaguidi, Bart Staels, Barbara Gross, Thérèse Hèrvée Mayi, Violeta Raverdi, Paola Allavena, François Pattou, Mehdi Daoudi, Kristiaan Wouters, Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Genfit, Entreprise biopharmaceutique GENFIT Loos, Thérapie cellulaire du diabète, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Service de chirurgie générale et endocrinienne, Hôpital Claude Huriez [Lille], CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Département de Nutrition, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Department of Immunology and Cell Biology, Mario Negri Institute, The research leading to these results has received funding from the 'Nouvelle Societé Française d'Athérosclérose / Sanofi-Aventis' (to Mayi T.H.), the 'Societé Française de Cardiologie / SanofiAventis', the COST Action BM0602 and the European Community's 7th Framework Programme (FP7/2007-2013) under grant agreement n° 201608. G. Chinetti-Gbaguidi is a recipient of a Contrat d'Interface from the CHRU de Lille. B. Staels is a member of the IUF., and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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obesity ,medicine.medical_specialty ,Chemokine ,Adipose tissue macrophages ,Adipose tissue ,chemokines ,Inflammation ,Biology ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Cell Line, Tumor ,Neoplasms ,Internal medicine ,Adipocytes ,medicine ,Humans ,cancer ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,Molecular Biology ,Oligonucleotide Array Sequence Analysis ,030304 developmental biology ,Regulation of gene expression ,0303 health sciences ,Cancer ,Cell Biology ,medicine.disease ,Immunohistochemistry ,macrophages ,adipose tissue ,Gene Expression Regulation, Neoplastic ,Phenotype ,Metabolism ,Endocrinology ,Cell culture ,030220 oncology & carcinogenesis ,Cancer cell ,Disease Progression ,Cancer research ,biology.protein ,medicine.symptom ,Azo Compounds - Abstract
International audience; Obesity is associated with a significantly increased risk for cancer suggesting that adipose tissue dysfunctions might play a crucial role therein. Macrophages play important roles in adipose tissue as well as in cancers. Here, we studied whether human adipose tissue macrophages (ATM) modulate cancer cell function. Therefore, ATM were isolated and compared with monocyte-derived macrophages (MDM) from the same obese patients. ATM, but not MDM, were found to secrete factors inducing inflammation and lipid accumulation in human T47D and HT-29 cancer cells. Gene expression profile comparison of ATM and MDM revealed overexpression of functional clusters, such as cytokine-cytokine receptor interaction (especially CXC-chemokine) signaling as well as cancer-related pathways, in ATM. Comparison with gene expression profiles of human tumor-associated macrophages showed that ATM, but not MDM resemble tumor-associated macrophages. Indirect co-culture experiments demonstrated that factors secreted by preadipocytes, but not mature adipocytes, confer an ATM-like phenotype to MDM. Finally, the concentrations of ATM-secreted factors related to cancer are elevated in serum of obese subjects. In conclusion, ATM may thus modulate the cancer cell phenotype.
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- 2012
- Full Text
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4. Impact of Procedure-Related Complications on Long-term Islet Transplantation Outcome
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Julie Kerr-Conte, Violeta Raverdi, F. Defrance, Thomas Hubert, Oliver Ernst, Géraldine Sergent, Marie-Christine Vantyghem, Clara Leroy, Valery Gmyr, Robert Caiazzo, François Pattou, Christian Noel, and Caroline Bonner
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Adult ,Male ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,Islets of Langerhans Transplantation ,Postoperative Complications ,medicine ,Humans ,Medical history ,Adverse effect ,Aged ,Proportional Hazards Models ,Transplantation ,geography ,Type 1 diabetes ,geography.geographical_feature_category ,business.industry ,Graft Survival ,Common Terminology Criteria for Adverse Events ,Middle Aged ,Islet ,medicine.disease ,Surgery ,Diabetes Mellitus, Type 1 ,Pancreatic islet transplantation ,Female ,business - Abstract
BACKGROUND Pancreatic islet transplantation offers a promising biotherapy for the treatment of type 1 diabetes, but this procedure has met significant challenges over the years. One such challenge is to address why primary graft function still remains inconsistent after islet transplantation. Several variables have been shown to affect graft function, but the impact of procedure-related complications on primary and long-term graft functions has not yet been explored. METHODS Twenty-six patients with established type 1 diabetes were included in this study. Each patient had two to three intraportal islet infusions to obtain 10,000 islet equivalent (IEQ)/kg in body weight, equaling a total of 68 islet infusions. Islet transplantation consisted of three sequential fresh islet infusions within 3 months. Islet infusions were performed surgically or under ultrasound guidance, depending on patient morphology, availability of the radiology suite, and patient medical history. Prospective assessment of adverse events was recorded and graded using "Common Terminology Criteria for adverse events in Trials of Adult Pancreatic Islet Transplantation." RESULTS There were no deaths or patients dropouts. Early complications occurred in nine of 68 procedures. β score 1 month after the last graft and optimal graft function (β score ≥7) rate were significantly lower in cases of procedure-related complications (P = 0.02, P = 0.03). Procedure-related complications negatively impacted graft function (P = 0.009) and was an independent predictive factor of long-term graft survival (P = 0.033) in multivariate analysis. CONCLUSION Complications occurring during radiologic or surgical intraportal islet transplantation significantly impair primary graft function and graft survival regardless of their severity.
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- 2014
5. P127 Impact de la grossesse sur les résultats de la chirurgie bariatrique
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Violeta Raverdi, François Pattou, Hélène Verkindt, Julien Couster, Eric Loridan, Philippe Deruelle, R. Caiazzo, Marie Pigeyre, and T.Q. Pham
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Nutrition and Dietetics ,Endocrinology, Diabetes and Metabolism ,Internal Medicine ,Medicine (miscellaneous) - Published
- 2013
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