114 results on '"Vining EP"'
Search Results
2. The algorithmic complexity of neural spike trains increases during focal seizures
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Rapp, PE, primary, Zimmerman, ID, additional, Vining, EP, additional, Cohen, N, additional, Albano, AM, additional, and Jimenez-Montano, MA, additional
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- 1994
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3. Ethosuximide in childhood absence epilepsy--older and better.
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Vining EP
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- 2010
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4. Understanding the ramifications of switching among AEDs: a 2008 clinical update.
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Hartman AL, Phelps SJ, and Vining EP
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- 2008
5. Rasmussen encephalitis tissue transfer program.
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Kruse CA, Pardo CA, Hartman AL, Jallo G, Vining EP, Voros J, Gaillard WD, Liu J, Oluigbo C, Malone S, Bleasel AF, Dexter M, Micati A, Velasco TR, Machado HR, Martino AM, Huang A, Wheatley BM, Grant GA, Granata T, Freri E, Garbelli R, Koh S, Nordli DR, Campos AR, O'Neill B, Handler MH, Chapman KE, Wilfong AA, Curry DJ, Yaun A, Madsen JR, Smyth MD, Mercer D, Bingaman W, Harvey AS, Leventer RJ, Lockhart PJ, Gillies G, Pope K, Giller CA, Park YD, Rojiani AM, Sharma SJ, Jenkins P, Tung S, Huynh MN, Chirwa TW, Cepeda C, Levine MS, Chang JW, Owens GC, Vinters HV, and Mathern GW
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- Humans, Specimen Handling statistics & numerical data, Specimen Handling trends, Encephalitis pathology, Tissue Banks statistics & numerical data, Tissue Banks trends
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- 2016
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6. Absence in childhood absence epilepsy: the horse is out of the barn.
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Vining EP and Thio LL
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- Child, Electroencephalography, Humans, Epilepsy, Absence diagnosis
- Abstract
Clinicians typically breathe a sigh of relief when they make the diagnosis of childhood absence epilepsy. The history is classic-a normal young child with myriad brief periods of staring. The clinic visit is powerful when the phenomena are replicated by having the child hyperventilate. Finally, the EEG is definitive. The ability to demonstrate to a family the abrupt eruption and cessation of spike-wave activity provides a framework for them to understand what is happening to their child. Parents are usually reassured that there are very good therapies, that seizures are typically controlled, and that their child will "outgrow" it. However, data from the multicenter Childhood Absence Epilepsy Study Group are rewriting this narrative.(1-3.)
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- 2013
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7. De novo mutations in epileptic encephalopathies.
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Allen AS, Berkovic SF, Cossette P, Delanty N, Dlugos D, Eichler EE, Epstein MP, Glauser T, Goldstein DB, Han Y, Heinzen EL, Hitomi Y, Howell KB, Johnson MR, Kuzniecky R, Lowenstein DH, Lu YF, Madou MR, Marson AG, Mefford HC, Esmaeeli Nieh S, O'Brien TJ, Ottman R, Petrovski S, Poduri A, Ruzzo EK, Scheffer IE, Sherr EH, Yuskaitis CJ, Abou-Khalil B, Alldredge BK, Bautista JF, Berkovic SF, Boro A, Cascino GD, Consalvo D, Crumrine P, Devinsky O, Dlugos D, Epstein MP, Fiol M, Fountain NB, French J, Friedman D, Geller EB, Glauser T, Glynn S, Haut SR, Hayward J, Helmers SL, Joshi S, Kanner A, Kirsch HE, Knowlton RC, Kossoff EH, Kuperman R, Kuzniecky R, Lowenstein DH, McGuire SM, Motika PV, Novotny EJ, Ottman R, Paolicchi JM, Parent JM, Park K, Poduri A, Scheffer IE, Shellhaas RA, Sherr EH, Shih JJ, Singh R, Sirven J, Smith MC, Sullivan J, Lin Thio L, Venkat A, Vining EP, Von Allmen GK, Weisenberg JL, Widdess-Walsh P, and Winawer MR
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- Child Development Disorders, Pervasive, Cohort Studies, Exome genetics, Female, Fragile X Mental Retardation Protein metabolism, Genetic Predisposition to Disease genetics, Humans, Infant, Intellectual Disability physiopathology, Lennox Gastaut Syndrome, Male, Mutation Rate, N-Acetylglucosaminyltransferases genetics, Probability, Receptors, GABA-A genetics, Spasms, Infantile physiopathology, Intellectual Disability genetics, Mutation genetics, Spasms, Infantile genetics
- Abstract
Epileptic encephalopathies are a devastating group of severe childhood epilepsy disorders for which the cause is often unknown. Here we report a screen for de novo mutations in patients with two classical epileptic encephalopathies: infantile spasms (n = 149) and Lennox-Gastaut syndrome (n = 115). We sequenced the exomes of 264 probands, and their parents, and confirmed 329 de novo mutations. A likelihood analysis showed a significant excess of de novo mutations in the ∼4,000 genes that are the most intolerant to functional genetic variation in the human population (P = 2.9 × 10(-3)). Among these are GABRB3, with de novo mutations in four patients, and ALG13, with the same de novo mutation in two patients; both genes show clear statistical evidence of association with epileptic encephalopathy. Given the relevant site-specific mutation rates, the probabilities of these outcomes occurring by chance are P = 4.1 × 10(-10) and P = 7.8 × 10(-12), respectively. Other genes with de novo mutations in this cohort include CACNA1A, CHD2, FLNA, GABRA1, GRIN1, GRIN2B, HNRNPU, IQSEC2, MTOR and NEDD4L. Finally, we show that the de novo mutations observed are enriched in specific gene sets including genes regulated by the fragile X protein (P < 10(-8)), as has been reported previously for autism spectrum disorders.
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- 2013
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8. Inter-rater agreement for diagnoses of epilepsy in pregnant women.
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Khoshbin S, Herring A, Holmes GL, Schomer D, Hoch D, Dooling EC, Vining EP, and Holmes LB
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- Adult, Electroencephalography, Female, Humans, Linear Models, Pediatrics, Physicians, Pregnancy, Retrospective Studies, Epilepsy diagnosis, Neurology
- Abstract
We report on inter-rater agreement in assessing the types of seizures exhibited by one hundred mothers ascertained in a study of the teratogenicity of maternal epilepsy and antiepileptic drugs. A summary of each woman's medical record and a one-page report of her responses to questions about her epilepsy were reviewed independently by six neurologists, three in pediatric neurology and three in adult neurology. Agreement was measured by the kappa statistic and log-linear modeling techniques. The adult neurologists agreed with each other 59% of the time, with the agreement higher when all three used information from the patients' records, such as an EEG, rather than when depending on the patients' responses to questions about their epilepsy. The pediatric neurologists agreed with each other 44% of the time and tended to rely more heavily on information in the patients' records, such as an EEG or a prior diagnosis, compared with the adult neurologists., (Copyright © 2013 Elsevier Inc. All rights reserved.)
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- 2013
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9. Cognitive and EEG fluctuation in benign childhood epilepsy with central-temporal spikes: a case series.
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Ewen JB, Vining EP, Smith CA, Trescher WH, Kossoff EH, Gordon B, and Boatman-Reich D
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- Child, Cognition Disorders epidemiology, Educational Status, Epilepsy, Rolandic epidemiology, Female, Humans, Male, Neuropsychological Tests, Phenotype, Risk Factors, Time Factors, Cognition physiology, Cognition Disorders diagnosis, Cognition Disorders physiopathology, Electroencephalography, Epilepsy, Rolandic diagnosis, Epilepsy, Rolandic physiopathology
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Aware of parental reports of academic variability, we investigated month-to-month fluctuations in cognitive abilities and EEG status by repeated measures testing in six children with benign epilepsy with central-temporal spikes (BECTS). All showed greater than normal test-retest variability. Daytime EEG abnormalities were also variable. Short-term fluctuations in cognitive function appear common in children with BECTS, potentially impacting academic performance., (Copyright © 2011 Elsevier B.V. All rights reserved.)
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- 2011
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10. Another nail in the coffin.
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Vining EP
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- 2010
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11. Sensorimotor function and sensorimotor tracts after hemispherectomy.
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Choi JT, Vining EP, Mori S, and Bastian AJ
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- Adolescent, Adult, Child, Diffusion Tensor Imaging, Female, Humans, Magnetic Resonance Imaging, Male, Models, Biological, Young Adult, Brain Diseases physiopathology, Brain Diseases surgery, Brain Stem physiopathology, Brain Stem surgery, Efferent Pathways physiopathology, Efferent Pathways surgery, Feedback, Sensory physiology, Hemispherectomy methods, Neural Pathways physiopathology
- Abstract
Hemispherectomy is currently the only effective treatment for relieving constant seizures in children with severe or progressive unilateral cortical disease. Although early hemispherectomy has been advocated to avoid general dysfunction due to continued seizures, it remains unclear whether age at surgery affects specific sensorimotor functions. Little is know about the anatomical status of sensorimotor pathways after hemispherectomy and how it might relate to sensorimotor function. Here we measured motor function and sensory thresholds of the upper and lower limbs in 12 hemispherectomized patients. Diffusion tensor imaging (DTI) was used to determine status of brainstem corticospinal tracts and medial lemniscus. Hemispherectomy subjects showed remarkable recovery in both sensory and motor function. Many patients showed normal sensory vibration thresholds. Within the smaller Rasmussen's subgroup, we saw a relationship between age at surgery and sensorimotor function recovery (i.e. earlier was better). Anatomically, we found marked asymmetry in brainstem corticospinal tracts but preserved symmetry in the medial lemniscus, which may relate to robust sensory recovery. Age at surgery predicted anatomical status of brainstem sensorimotor tracts. In sum, we found that age at surgery influences anatomical changes in brainstem motor pathways, and may also relate to sensorimotor recovery patterns., ((c) 2009 Elsevier Ltd. All rights reserved.)
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- 2010
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12. Tonic and atonic seizures: medical therapy and ketogenic diet.
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Vining EP
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- Catastrophic Illness therapy, Combined Modality Therapy, Electroencephalography, Epilepsy, Generalized therapy, Humans, Risk Factors, Syndrome, Treatment Outcome, Triglycerides therapeutic use, Anticonvulsants therapeutic use, Diet, Ketogenic methods, Epilepsy, Generalized diet therapy, Epilepsy, Generalized drug therapy
- Abstract
Tonic and atonic seizures are typically seen in what are often referred to as the catastrophic epilepsies. In simply considering what each of the terms signifies (either the complete loss of tone or a marked increase in tone), they would appear to be at the most diverse ends of the spectrum. They would appear to be as opposite as hot and cold or hard and soft. And yet they are often found to occur in the same patient. This article examines the nature of these seizures and discusses some of the syndromes in which they are seen. Although these seizures are often very difficult to control, some of our medications/therapies have been shown to be effective. Recommendations concerning the efficacy of these therapies and a review of the newer therapies are provided. In addition, the ketogenic diet has been particularly successful in treating these seizures; this is discussed in some detail. Finally, although outcomes for these children are generally less than ideal, many can be helped with a persistent approach that balances seizure control against the side effects of medication.
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- 2009
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13. Hemispherectomy sustained before adulthood does not cause persistent hemispatial neglect.
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Marsh EB, Newhart M, Kleinman JT, Heidler-Gary J, Vining EP, Freeman JM, Kossoff EH, and Hillis AE
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- Adaptation, Psychological, Adolescent, Adult, Age Factors, Child, Critical Period, Psychological, Female, Functional Laterality, Humans, Male, Young Adult, Adaptation, Physiological, Epilepsy surgery, Hemispherectomy adverse effects, Neuronal Plasticity, Perceptual Disorders etiology, Recovery of Function
- Abstract
Introduction: Hemispatial neglect has been well established in adults following acute ischemic stroke, but has rarely been investigated in children and young adults following brain injury. It is known that young brains have a tremendous potential for reorganization; however, there is controversy as to whether functions are assumed by the opposite hemisphere, or perilesional areas in the same hemisphere. Patients with intractable epilepsy who undergo hemispherectomy for treatment are missing the entire cortex on one side following surgery. In these patients, only the opposite hemisphere is available to assume function. Therefore, they provide the unique opportunity to determine in what cases the left or right hemisphere can take over the spatial attention functions of the opposite hemisphere following damage. The objective of this study was to determine the incidence and types of hemispatial neglect in children and young adults following both right- and left-sided hemispherectomy; which types of spatial attention functions can be assumed by the opposite hemisphere; and whether factors like their age at time of surgery, handedness, or gender influence recovery., Methods: Thirty-two children and young adults who had previously undergone hemispherectomy were administered two tests to evaluate for two types of hemispatial neglect: a gap detection test and a line cancellation test. Egocentric neglect was defined as significantly more omissions of targets on the contralesional versus ipsilesional side of the page (by chi square analysis; p<.05). Allocentric neglect was defined as significantly more errors in detecting contralesional versus ipsilesional gaps in circles., Results: Only one of the patients displayed statistically significant hemispatial egocentric neglect on the line cancellation test, and none of the patients displayed statistically significant egocentric or allocentric neglect on the gap detection test., Conclusions: These results imply that reorganization to the contralateral hemisphere occurs peri-hemispherectomy, as there are no perilesional areas to assume function.
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- 2009
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14. High-dose oral prednisolone for infantile spasms: an effective and less expensive alternative to ACTH.
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Kossoff EH, Hartman AL, Rubenstein JE, and Vining EP
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- Administration, Oral, Adrenocorticotropic Hormone therapeutic use, Female, Humans, Infant, Male, Retrospective Studies, Glucocorticoids administration & dosage, Prednisolone administration & dosage, Spasms, Infantile drug therapy
- Abstract
The ideal treatment of infantile spasms is unclear, but many studies advocate hormonal treatment. In the United States, intramuscular ACTH is most widely used, despite the problematic financial cost and side effect profile. Since September 2007, we have replaced ACTH with high-dose oral prednisolone (40-60 mg/day) according to the 2004 United Kingdom Infantile Spasms Study (UKISS). Ten of 15 (67%) infants with new-onset and previously treated infantile spasms became spasm free within 2 weeks; 4 later recurred. More children with an idiopathic etiology for infantile spasms were spasm free than were symptomatic cases (88% vs 43%, P=0.10). Spasm freedom was equivalent to our most recent 15 infants receiving ACTH, with 13 (87%) responding, P=0.16. Oral prednisolone had fewer adverse effects (53% vs 80%, P=0.10) and was less expensive ($200 vs approximately $70,000) than ACTH. We now routinely recommend oral prednisolone to all families of children with infantile spasms.
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- 2009
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15. Walking flexibility after hemispherectomy: split-belt treadmill adaptation and feedback control.
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Choi JT, Vining EP, Reisman DS, and Bastian AJ
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- Adolescent, Brain physiopathology, Cerebellum physiopathology, Child, Epilepsy surgery, Exercise Test methods, Female, Humans, Learning physiology, Male, Postoperative Period, Psychomotor Performance physiology, Adaptation, Physiological physiology, Feedback physiology, Hemispherectomy rehabilitation, Walking physiology
- Abstract
Walking flexibility depends on use of feedback or reactive control to respond to unexpected changes in the environment, and the ability to adapt feedforward or predictive control for sustained alterations. Recent work has demonstrated that cerebellar damage impairs feedforward adaptation, but not feedback control, during human split-belt treadmill walking. In contrast, focal cerebral damage from stroke did not impair either process. This led to the suggestion that cerebellar interactions with the brainstem are more important than those with cerebral structures for feedforward adaptation. Does complete removal of a cerebral hemisphere affect either of these processes? We studied split-belt walking in 10 children and adolescents (age 6-18 years) with hemispherectomy (i.e. surgical removal of one entire cerebral hemisphere) and 10 age- and sex-matched control subjects. Hemispherectomy did not impair reactive feedback control, though feedforward adaptation was impaired in some subjects. Specifically, some showed reduced or absent adaptation of inter-leg timing, whereas adaptation of spatial control was intact. These results suggest that the cerebrum is involved in adaptation of the timing, but not spatial, elements of limb movements.
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- 2009
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16. Optimal clinical management of children receiving the ketogenic diet: recommendations of the International Ketogenic Diet Study Group.
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Kossoff EH, Zupec-Kania BA, Amark PE, Ballaban-Gil KR, Christina Bergqvist AG, Blackford R, Buchhalter JR, Caraballo RH, Helen Cross J, Dahlin MG, Donner EJ, Klepper J, Jehle RS, Kim HD, Christiana Liu YM, Nation J, Nordli DR Jr, Pfeifer HH, Rho JM, Stafstrom CE, Thiele EA, Turner Z, Wirrell EC, Wheless JW, Veggiotti P, and Vining EP
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- Anticonvulsants therapeutic use, Child, Combined Modality Therapy, Contraindications, Dietary Supplements, Drug Resistance, Epilepsy diagnosis, Humans, Patient Care Team, Diet, Ketogenic adverse effects, Epilepsy diet therapy, Evidence-Based Medicine
- Abstract
The ketogenic diet (KD) is an established, effective nonpharmacologic treatment for intractable childhood epilepsy. The KD is provided differently throughout the world, with occasionally significant variations in its administration. There exists a need for more standardized protocols and management recommendations for clinical and research use. In December 2006, The Charlie Foundation commissioned a panel comprised of 26 pediatric epileptologists and dietitians from nine countries with particular expertise using the KD. This group was created in order to create a consensus statement regarding the clinical management of the KD. Subsequently endorsed by the Practice Committee of the Child Neurology Society, this resultant manuscript addresses issues such as patient selection, pre-KD counseling and evaluation, specific dietary therapy selection, implementation, supplementation, follow-up management, adverse event monitoring, and eventual KD discontinuation. This paper highlights recommendations based on best evidence, including areas of agreement and controversy, unanswered questions, and future research.
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- 2009
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17. A blinded, crossover study of the efficacy of the ketogenic diet.
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Freeman JM, Vining EP, Kossoff EH, Pyzik PL, Ye X, and Goodman SN
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- 3-Hydroxybutyric Acid urine, Child, Child, Preschool, Cross-Over Studies, Double-Blind Method, Electroencephalography, Epilepsies, Myoclonic urine, Epilepsy, Generalized urine, Female, Glucose Solution, Hypertonic administration & dosage, Humans, Infant, Ketones urine, Male, Saccharin administration & dosage, Syndrome, Diet, Ketogenic, Epilepsies, Myoclonic diet therapy, Epilepsy, Generalized diet therapy
- Abstract
Despite over 80 years of use, the ketogenic diet (KD) has never been tested in a blinded manner. Twenty children with intractable Lennox-Gastaut syndrome (LGS) were fasted 36 h and then randomized to receive the classic KD in conjunction with a solution containing either 60 g/day of glucose or saccharin. Parents and physicians were blinded to both the solution composition and level of ketosis. A crossover to the KD with the alternate solution occurred following the sixth day and a repeat fast. A 24-h electroencephalography (EEG) was obtained at baseline and after each arm. After administration of the solution, there was moderate evidence of a reduction in parent-reported seizures between the glucose and saccharin arms, with a median difference of 1.5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm.
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- 2009
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18. Long-term health consequences of epilepsy diet treatments.
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Vining EP
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- Child, Humans, Diet, Ketogenic adverse effects, Epilepsy diet therapy
- Abstract
The ketogenic diet (KD) typically provides a marginally healthy diet and in recent years has been used for more protracted courses of therapy. This results in concern about the impact of the diet on the general health of the child. Studies have demonstrated poor growth, dyslipidemia, kidney stones, and numerous other problems seen less frequently. Major areas of concern are reviewed as well as some emerging evidence of more beneficial long-term health consequences beyond the expected control of seizures.
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- 2008
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19. You've come a long way, baby: or have you?
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Vining EP
- Published
- 2008
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20. Cortical auditory dysfunction in benign rolandic epilepsy.
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Boatman DF, Trescher WH, Smith C, Ewen J, Los J, Wied HM, Gordon B, Kossoff EH, Gao Q, and Vining EP
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- Attention physiology, Auditory Perceptual Disorders diagnosis, Brain Stem physiopathology, Child, Contingent Negative Variation physiology, Diagnosis, Differential, Dominance, Cerebral physiology, Electroencephalography, Epilepsy, Rolandic diagnosis, Evoked Potentials, Auditory physiology, Evoked Potentials, Auditory, Brain Stem physiology, Female, Hearing Tests, Humans, Male, Perceptual Masking physiology, Reaction Time physiology, Signal Processing, Computer-Assisted, Speech Reception Threshold Test, Auditory Cortex physiopathology, Auditory Perceptual Disorders physiopathology, Epilepsy, Rolandic physiopathology, Speech Perception physiology, Temporal Lobe physiopathology
- Abstract
Purpose: To evaluate cortical auditory function, including speech recognition, in children with benign rolandic epilepsy (BRE)., Methods: Fourteen children, seven patients with BRE and seven matched controls, underwent audiometric and behavioral testing, simultaneous EEG recordings, and auditory-evoked potential recordings with speech and tones. Speech recognition was tested under multiple listening conditions., Results: All participants demonstrated normal speech recognition abilities in quiet, as well as normal peripheral and subcortical auditory function. BRE patients performed significantly worse than controls when speech recognition was tested under adverse listening conditions, including background noise. Five BRE patients who were impaired on two or more tests had centrotemporal spiking on awake EEG. There were no significant group differences in the latency or amplitude of early N100 cortical responses to speech or tones. Conversely, the mismatch negativity, a preattentive index of cortical processing that is elicited passively, was absent or prolonged for speech, but not tones, in BRE patients as compared to controls., Discussion: Children with BRE demonstrated specific speech recognition impairments. Our evoked potential findings indicate that these behavioral impairments reflect dysfunction of nonprimary auditory cortex and cannot be attributed solely to attention difficulties. A possible association between auditory impairments and centrotemporal spiking (>1/min) on awake EEG was identified. The pattern of speech recognition impairments observed is a known risk factor for academic difficulties in school-age children. Our results underscore the importance of comprehensive auditory testing, using behavioral and electrophysiological measures, in children with BRE.
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- 2008
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21. A prospective study of the modified Atkins diet for intractable epilepsy in adults.
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Kossoff EH, Rowley H, Sinha SR, and Vining EP
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- Adolescent, Adult, Age Factors, Anticonvulsants therapeutic use, Blood Urea Nitrogen, Body Mass Index, Calcium urine, Combined Modality Therapy, Creatinine urine, Diet, Carbohydrate-Restricted adverse effects, Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Epilepsy metabolism, Female, Humans, Hypercholesterolemia chemically induced, Ketosis chemically induced, Male, Patient Dropouts, Prospective Studies, Treatment Outcome, Weight Loss, Diet, Carbohydrate-Restricted methods, Epilepsy diet therapy
- Abstract
Purpose: The ketogenic diet is not typically offered to adults with epilepsy due to the significant lifestyle alterations needed for its use. The modified Atkins diet has been recently demonstrated to be therapeutic for children without the need for an admission, fasting period, weighing of foods, or fluid, calorie, and protein restriction., Methods: A prospective, open-label study was performed of adults over 18 years of age, having at least weekly seizures and prior use of at least two anticonvulsants. Carbohydrates were initially restricted to 15 g/day, fats were encouraged, and fluids, protein, and calories were allowed ad lib., Results: Thirty patients, with age ranging from 18 to 53 years, were enrolled. Using an intent-to-treat analysis, 47% had a >50% seizure reduction after 1 and 3 months on the diet; 33% after 6 months. In those with seizure reduction, the median time to improvement was 2 weeks (range: 1-8 weeks). The mean weight loss was 6.8 kg, p < 0.001. Body-mass index (BMI) decrease correlated with efficacy at 3 months, p = 0.03. Ten subjects (30%) discontinued the diet prior to 3 months. Side effects included increased cholesterol (mean 187 to 201 mg/dL), blood urea nitrogen (BUN; 13 to 16 mg/dL), and urine calcium to creatinine ratio (0.14 to 0.19)., Conclusions: A modified Atkins diet appears to demonstrate preliminary efficacy for adults with intractable epilepsy, especially in those who lost weight. Considering the rapid response in those who improved, but somewhat high discontinuation rate, a 2-month trial period may be adequate to assess for efficacy.
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- 2008
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22. Children with seizures exhibit preferences for foods compatible with the ketogenic diet.
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Amari A, Dahlquist L, Kossoff EH, Vining EP, Trescher WH, and Slifer KJ
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- Adolescent, Analysis of Variance, Caregivers psychology, Case-Control Studies, Child, Child, Preschool, Cross-Sectional Studies, Diet, Carbohydrate-Restricted, Diet, Protein-Restricted, Dietary Fats metabolism, Female, Food Preferences physiology, Humans, Ketone Bodies metabolism, Ketone Bodies therapeutic use, Male, Matched-Pair Analysis, Seizures metabolism, Seizures psychology, Choice Behavior, Dietary Fats therapeutic use, Feeding Behavior psychology, Food Preferences psychology, Seizures diet therapy
- Abstract
Although highly effective for the treatment of intractable epilepsy, the ketogenic diet is not always included in the treatment option hierarchy presented to families, in part due to perceptions that children will find the high-fat/low-carbohydrate regimen unpalatable. This study assessed if children with seizures exhibit food preferences compatible with the diet, as well as if caregivers were accurate in predicting preferences. Children aged 2-17, with (n=29) and without (n=30) a history of seizures, participated in a paired choice food preference assessment while parents estimated child preferences verbally. Children with seizures exhibited significantly higher preferences for fat versus carbohydrate foods compared with controls, and parents demonstrated low accuracy. Future studies could use similar assessment methods to prospectively track whether such preferences predict diet compliance and/or efficacy. Research into the underlying metabolic basis for this preference and possible related neurophysiological mechanisms in seizure etiology and treatment is warranted.
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- 2007
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23. A randomized, crossover comparison of daily carbohydrate limits using the modified Atkins diet.
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Kossoff EH, Turner Z, Bluml RM, Pyzik PL, and Vining EP
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- Adolescent, Child, Child, Preschool, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Epilepsy complications, Female, Follow-Up Studies, Humans, Ketosis drug therapy, Ketosis etiology, Male, Diet, Carbohydrate-Restricted methods, Dietary Carbohydrates therapeutic use, Epilepsy diet therapy
- Abstract
The modified Atkins diet is a dietary therapy for intractable epilepsy that mimics the ketogenic diet, yet does not restrict protein, calories, and fluids. The ideal starting carbohydrate limit is unknown. Twenty children with intractable epilepsy were randomized to either 10 or 20 g of carbohydrates per day for the initial 3 months of the modified Atkins diet, and then crossed over to the opposite amount. A significantly higher likelihood of >50% seizure reduction was noted for children started on 10 g of carbohydrate per day at 3 months: 60% versus 10% (P=0.03). Most parents reported no change in seizure frequency or ketosis between groups, but improved tolerability with 20 g per day. A starting carbohydrate limit of 10 g per day for children starting the modified Atkins diet may be ideal, with a planned increase to a more tolerable 20 g per day after 3 months.
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- 2007
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24. The neuropharmacology of the ketogenic diet.
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Hartman AL, Gasior M, Vining EP, and Rogawski MA
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- Animals, Brain metabolism, Child, Epilepsy metabolism, Humans, Brain drug effects, Diet, Carbohydrate-Restricted methods, Epilepsy diet therapy, Ketone Bodies pharmacology
- Abstract
The ketogenic diet is a valuable therapeutic approach for epilepsy, one in which most clinical experience has been with children. Although the mechanism by which the diet protects against seizures is unknown, there is evidence that it causes effects on intermediary metabolism that influence the dynamics of the major inhibitory and excitatory neurotransmitter systems in brain. The pattern of protection of the ketogenic diet in animal models of seizures is distinct from that of other anticonvulsants, suggesting that it has a unique mechanism of action. During consumption of the ketogenic diet, marked alterations in brain energy metabolism occur, with ketone bodies partly replacing glucose as fuel. Whether these metabolic changes contribute to acute seizure protection is unclear; however, the ketone body acetone has anticonvulsant activity and could play a role in the seizure protection afforded by the diet. In addition to acute seizure protection, the ketogenic diet provides protection against the development of spontaneous recurrent seizures in models of chronic epilepsy, and it has neuroprotective properties in diverse models of neurodegenerative disease.
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- 2007
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25. Kidney stones and the ketogenic diet: risk factors and prevention.
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Sampath A, Kossoff EH, Furth SL, Pyzik PL, and Vining EP
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- Administration, Oral, Age of Onset, Child, Preschool, Cohort Studies, Dietary Fats administration & dosage, Epilepsy diet therapy, Epilepsy drug therapy, Female, Humans, Kidney Calculi epidemiology, Male, Retrospective Studies, Risk Factors, Urinary Calculi drug therapy, Urinary Calculi etiology, Urinary Calculi prevention & control, Dietary Fats adverse effects, Kidney Calculi etiology, Kidney Calculi prevention & control, Potassium Citrate administration & dosage
- Abstract
A cohort study was performed of children started on the ketogenic diet for intractable epilepsy from 2000 to 2005 (n = 195). Children who developed kidney stones were compared with those without in terms of demographics, urine laboratory markers, and intervention with urine alkalinization (potassium citrate). Thirteen children (6.7%) developed kidney stones. The use of oral potassium citrate significantly decreased the prevalence of stones (3.2% vs 10.0%, P = .049) and increased the mean time on the ketogenic diet before a stone was first noted (260 vs 149 patient-months, P = .29). The prevalence of kidney stones did not correlate with younger age or use of carbonic anhydrate inhibitors (eg, topiramate or zonisamide) but trended toward higher correlation with the presence of hypercalciuria (92% vs 71%, P = .08). No child stopped the diet due to stones; in fact, the total diet duration was longer (median 26 vs 12 months, P < .001). Kidney stones continue to occur in approximately 1 in 20 children on the ketogenic diet, and no statistically significant risk factors were identified in this cohort. As oral potassium citrate was preventative, prospective studies using this medication empirically are warranted.
- Published
- 2007
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26. Clinical aspects of the ketogenic diet.
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Hartman AL and Vining EP
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- Child, Preschool, Clinical Trials as Topic, Diet Therapy methods, Diet, Carbohydrate-Restricted, Dietary Carbohydrates metabolism, Dietary Fats metabolism, Dietary Proteins metabolism, Epilepsy metabolism, Humans, Infant, Ketone Bodies biosynthesis, Ketone Bodies metabolism, Treatment Outcome, Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Dietary Proteins administration & dosage, Epilepsy diet therapy, Ketosis metabolism
- Abstract
The ketogenic diet remains a valuable therapeutic option for patients with intractable epilepsy. Clinical aspects of the diet's success may provide insights into epileptogenesis and anticonvulsant action. The diet's efficacy has been established primarily through large case series. The diet has been used successfully in patients with many different epilepsy syndromes in countries around the world. Potential adverse effects can be avoided with careful attention during the diet's initiation and maintenance phases. In the last decade, variations to the classical ketogenic diet have been utilized. Ketogenic diets now are being used for diseases other than epilepsy. This critical analysis of the diet should provide the impetus for further clinical and basic research into the diet's application and mechanisms of action.
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- 2007
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27. The importance of parental expectations of cognitive improvement for their children with epilepsy prior to starting the ketogenic diet.
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Farasat S, Kossoff EH, Pillas DJ, Rubenstein JE, Vining EP, and Freeman JM
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- Anticonvulsants therapeutic use, Attitude, Child, Epilepsy drug therapy, Epilepsy psychology, Female, Humans, Male, Cognition physiology, Dietary Fats therapeutic use, Epilepsy diet therapy, Goals, Ketosis metabolism, Parents psychology
- Abstract
Although the success rates and complications of various treatment options for children with intractable epilepsy have been described, the actual expectations of parents for these treatments are less clear. Since 1998, parents at our institution have written their goals in a letter before starting their children on the ketogenic diet. One hundred consecutive letters were evaluated. The most common first goal was seizure improvement, second was anticonvulsant reduction, and third was cognitive improvement. Ninety percent requested improvement in cognition or alertness. These expectations were either met or exceeded at 6 months in 52-60% of children. Achieving or surpassing parental expectations for cognitive improvement correlated with longer diet duration (P=0.04), but meeting goals for seizure or anticonvulsant reduction did not. Cognitive improvement (P<0.001) and >90% seizure reduction (P=0.04) at 6 months positively correlated with longer eventual diet duration. Expectations for cognitive improvement need to be discussed prior to beginning the ketogenic diet.
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- 2006
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28. A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy.
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Kossoff EH, McGrogan JR, Bluml RM, Pillas DJ, Rubenstein JE, and Vining EP
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- Adolescent, Age Factors, Anticonvulsants therapeutic use, Blood Urea Nitrogen, Child, Child, Preschool, Cholesterol blood, Creatinine blood, Dietary Fats administration & dosage, Dietary Fats metabolism, Dietary Proteins administration & dosage, Dietary Proteins metabolism, Epilepsy blood, Epilepsy metabolism, Female, Follow-Up Studies, Humans, Ketones urine, Ketosis blood, Ketosis etiology, Ketosis urine, Male, Nitrogen blood, Treatment Outcome, Weight Loss, Diet, Carbohydrate-Restricted methods, Epilepsy diet therapy
- Abstract
Purpose: The Atkins diet may induce ketosis as does the ketogenic diet, without restrictions on calories, fluids, protein, or need for an inpatient fast and admission. Our objective was to evaluate the efficacy and tolerability of a modified Atkins diet for intractable childhood epilepsy., Methods: Twenty children were treated prospectively in a hospital-based ambulatory clinic from September 2003 to May 2005. Children aged 3-18 years, with at least three seizures per week, who had been treated with at least two anticonvulsants, were enrolled and received the diet over a 6-month period. Carbohydrates were initially limited to 10 g/day, and fats were encouraged. Parents measured urinary ketones semiweekly and recorded seizures daily. All children received vitamin and calcium supplementation., Results: In all children, at least moderate urinary ketosis developed within 4 days (mean, 1.9). Sixteen (80%) completed the 6-month study; 14 chose to remain on the diet afterward. At 6 months, 13 (65%) had >50% improvement, and seven (35%) had >90% improvement (four were seizure free). Mean seizure frequency after 6 months was 40 per week (p = 0.005). Over a 6-month period, mean serum blood urea nitrogen increased from 12 to 17 mg/dl (p = 0.01); creatinine was unchanged. Cholesterol increased from 192 to 221 mg/dl, (p = 0.06). Weight did not change significantly (34.0-33.7 kg); only six children lost weight. A stable body mass index over time correlated with >90% improvement (p = 0.004)., Conclusions: A modified Atkins diet is an effective and well-tolerated therapy for intractable pediatric epilepsy.
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- 2006
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29. The outcome of children with intractable seizures: a 3- to 6-year follow-up of 67 children who remained on the ketogenic diet less than one year.
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Marsh EB, Freeman JM, Kossoff EH, Vining EP, Rubenstein JE, Pyzik PL, and Hemingway C
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- Adolescent, Adult, Anticonvulsants therapeutic use, Child, Child, Preschool, Cohort Studies, Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Dietary Proteins administration & dosage, Drug Resistance, Epilepsy drug therapy, Epilepsy surgery, Female, Follow-Up Studies, Humans, Infant, Ketone Bodies biosynthesis, Ketone Bodies blood, Ketosis etiology, Longitudinal Studies, Male, Patient Compliance, Treatment Outcome, Diet Therapy methods, Epilepsy diet therapy, Ketosis metabolism
- Abstract
Purpose: To determine the long-term outcome of children with difficult-to-control seizures who remained on the ketogenic diet for <1 year., Methods: Between 1994 and 1996, 150 children with epilepsy, refractory to at least two medications, initiated the ketogenic diet according to the Hopkins protocol. Three to six years after diet initiation, all the families were contacted by telephone or questionnaire to assess their child's current seizure status, medications, and therapies., Results: Sixty-seven children discontinued the diet within 1 year of initiation. Follow-up data were available for 54 of these children. Ten subsequently had surgery, and three underwent VNS implantation. These operated-on children were significantly more likely to be >50% controlled at follow-up than were those managed with medications alone (p < 0.05). A statistically significant difference in long-term outcome was noted between those who responded while on the diet, even if they discontinued it before 1 year, and those who did not (p < 0.05), but no statistical correlation was found between length of time that they had remained on the diet and long-term prognosis., Conclusions: Almost half of the children who discontinued the diet during the first year had a decrease in seizures when assessed 3-6 years later. Twenty-two percent of these had become seizure free without surgery. We were unable to ascertain whether this may have been due to new medications. Those who saw some improvement while on the diet were more likely to have a favorable long-term outcome. Resective surgery, in children who were candidates, or vagal nerve stimulation (VNS) implantation, was more likely to result in significant seizure improvement than was management with medications alone. Whether or not the diet was effective, most families did not regret trying it and would recommend it to others.
- Published
- 2006
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30. Struggling with Rasmussen's syndrome.
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Vining EP
- Published
- 2006
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31. Will my child grow up and be normal?
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Vining EP
- Published
- 2005
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32. Can you predict an immediate, complete, and sustained response to the ketogenic diet?
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Than KD, Kossoff EH, Rubenstein JE, Pyzik PL, McGrogan JR, and Vining EP
- Subjects
- Body Mass Index, Case-Control Studies, Child, Preschool, Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Dietary Fats metabolism, Dietary Proteins administration & dosage, Epilepsy diagnosis, Epilepsy metabolism, Female, Humans, Infant, Male, Prognosis, Retrospective Studies, Spasms, Infantile diagnosis, Spasms, Infantile diet therapy, Spasms, Infantile metabolism, Treatment Outcome, Epilepsy diet therapy, Food, Formulated, Ketosis metabolism
- Abstract
Purpose: Although the ketogenic diet has been in use for >80 years, little agreement exists as to which patients are most likely to have dramatic, sudden, and complete seizure control., Methods: A case-control study was performed of children with intractable epilepsy started on the ketogenic diet at our institution since June 2001. Patients with a dramatic response were defined as those becoming seizure free within 2 weeks of diet onset. These children were compared with all other patients treated with the diet over the same time period in terms of patient demographics, epilepsy characteristics, and diet parameters., Results: Eighteen early, dramatic responders over a 3-year period were identified and compared with 89 patients who were not similarly improved. The absence of complex partial seizures as the predominant seizure type (0 vs. 23%; p = 0.02) correlated with this dramatic success. The presence of infantile spasms (39% vs. 20%; p = 0.09) approached significance, but all other variables did not., Conclusions: An early, dramatic response to the ketogenic diet is more likely in patients with predominant seizure types other than complex partial. It may also be more likely to occur in children who have infantile spasms. In all other patient demographics and diet parameters, an equal likelihood of similar success was found.
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- 2005
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33. Experience in the use of the ketogenic diet as early therapy.
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Rubenstein JE, Kossoff EH, Pyzik PL, Vining EP, McGrogan JR, and Freeman JM
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- Age of Onset, Child, Child, Preschool, Drug Resistance, Female, Humans, Infant, Ketones, Male, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Dietary Fats, Epilepsy diet therapy
- Abstract
The ketogenic diet has traditionally been considered an anticonvulsant therapy of last resort, despite excellent efficacy and limited side effects. We hypothesized that the ketogenic diet would have similar results in patients with new-onset epilepsy. A retrospective study was conducted of patients started on the ketogenic diet since 1994. Thirteen of 460 (2.8%) patients were started on the ketogenic diet as early (zero or one prior anticonvulsant) therapy for seizures. Of those remaining on the diet, 60% (6 of 10) had a > 90% seizure reduction at 6 months and 100% (6 of 6) had a > 90% reduction at 12 months. Patients with infantile spasms were as likely to achieve > 50% seizure reduction at 6 months as patients with other seizure types (75% vs 60%; P = .6). The ketogenic diet can be a valuable therapy before epilepsy becomes intractable. In the 13 patients reported, efficacy without side effects was achieved similarly to that with patients with intractable epilepsy.
- Published
- 2005
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34. The pathology of Rasmussen syndrome: stages of cortical involvement and neuropathological studies in 45 hemispherectomies.
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Pardo CA, Vining EP, Guo L, Skolasky RL, Carson BS, and Freeman JM
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- Age of Onset, Autoimmune Diseases immunology, Autoimmune Diseases pathology, Cerebral Cortex immunology, Cerebral Cortex metabolism, Child, Disease Progression, Encephalitis diagnosis, Female, Humans, Immunohistochemistry, Male, Neuroglia immunology, Neuroglia pathology, Occipital Lobe immunology, Occipital Lobe metabolism, Occipital Lobe pathology, Severity of Illness Index, T-Lymphocytes immunology, T-Lymphocytes pathology, Treatment Outcome, Cerebral Cortex pathology, Encephalitis pathology, Encephalitis surgery, Hemispherectomy methods
- Abstract
Purpose: Rasmussen syndrome (RS) is a rare form of epilepsy characterized by progressive destruction of a single hemisphere. To characterize the profile of cortical involvement in RS, we studied the pathological changes in the cerebral cortex of 45 hemispherectomies performed at Johns Hopkins Hospital between 1985 and 2002., Methods: The patterns of pathologic changes and stages of cortical abnormalities were studied by histology and immunocytochemistry methods. The burden of pathology (BP) was quantified in all brain regions of each of the 45 hemispheres., Results: Our study demonstrated significant heterogeneity in the stages of cortical pathology and the multifocal nature of the disease. These stages varied from early inflammation defined by infiltration of T lymphocytes and neuroglial reactions, to more severe stages with extensive neuronal cell death and cavitation of the cerebral cortex. A greater BP was significantly associated with an early age at onset (p = 0.01) and longer duration of disease (p < or = 0.001). The BP was similar in all brain regions except the occipital lobe, where the BP was significantly lower (p = 0.032)., Conclusions: The multifocal distribution of pathologic changes, as well as the heterogeneity in the stages of cortical damage in each patient, is consistent with an ongoing and progressive immune-mediated process of neuronal damage that involves neuroglial and lymphocytic responses, resembling other autoimmune CNS disorders such as multiple sclerosis.
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- 2004
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35. The cognitive outcome of hemispherectomy in 71 children.
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Pulsifer MB, Brandt J, Salorio CF, Vining EP, Carson BS, and Freeman JM
- Subjects
- Child, Cross-Sectional Studies, Epilepsy diagnosis, Female, Follow-Up Studies, Humans, Male, Neuropsychological Tests, Severity of Illness Index, Treatment Outcome, Cognition Disorders diagnosis, Cognition Disorders etiology, Epilepsy surgery, Functional Laterality, Hemispherectomy
- Abstract
Purpose: Long-term neuropsychological outcome was studied in 71 patients who underwent hemispherectomy for severe and intractable seizures at The Johns Hopkins Hospital between 1968 and 1997 and who agreed to participate. Seizures were due to cortical dysplasias (n = 27), Rasmussen syndrome (n = 37), or vascular malformations or strokes (n = 7). Both presurgical and follow-up results are available and reported for 53 patients., Methods: Patients and caretakers were interviewed, and patients were administered standard measures of intelligence, receptive and expressive language, visual-motor skills, adaptive/developmental functioning, and behavior., Results: Mean age at surgery was 7.2 years. At follow-up, on average 5.4 years after surgery, 65% are seizure free, 49% are medication free, and, of those responding, none rated quality of life as worse than before surgery. Mean IQ was in the 70s for Rasmussen and vascular patients and in the 30s for cortical dysplasia patients. Language and visual-motor skills were consistent with IQ. For Rasmussen patients only, language was significantly more impaired for left than for right hemispherectomy, both before surgery and at follow-up. Adaptive skills were mildly impaired, with greatest impairment in the physical domain. Cognitive measures typically changed little between surgery and follow-up, with IQ change <15 points for 34 of 53 patients; of the remainder, 11 declined and eight improved. Behavior was free of major problems, but social interactions and activities were limited., Conclusions: The most significant predictor of cognitive skills at follow-up was etiology, with dysplasia patients scoring lowest in intelligence and language but not in visual-motor skills. Regardless of etiology, most patients showed only moderate change in cognitive performance at follow-up.
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- 2004
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36. Practice parameter: evaluation of the child with global developmental delay.
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Crawford TO, Comi A, Freeman JM, Kossoff EH, Singer H, Vining EP, and Yohay K
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- Child, Diagnostic Techniques, Neurological economics, Diagnostic Tests, Routine economics, Humans, Pediatrics standards, Practice Guidelines as Topic standards, Predictive Value of Tests, Developmental Disabilities diagnosis, Diagnostic Techniques, Neurological standards, Neurology methods, Neurology standards
- Published
- 2003
37. Hemispherectomy for intractable unihemispheric epilepsy etiology vs outcome.
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Kossoff EH, Vining EP, Pillas DJ, Pyzik PL, Avellino AM, Carson BS, and Freeman JM
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- Adolescent, Brain Diseases complications, Child, Child, Preschool, Humans, Seizures prevention & control, Treatment Outcome, Brain Diseases surgery, Epilepsy etiology, Epilepsy surgery, Functional Laterality, Hemispherectomy
- Abstract
Background: Surgical removal of one hemisphere has been performed for several decades to treat intractable unihemispheric epilepsy. A prior case series focused on the outcomes after 58 surgeries at Johns Hopkins Hospital in 1997. This series, and an additional 53 cases, were reviewed to bring the outcomes up to date., Methods: Charts of the 111 patients undergoing hemidecortications at the Pediatric Epilepsy Center from 1975 to 2001 were reviewed and families were contacted. Three children died in the immediate perioperative period and three were lost to follow-up immediately after surgery. Follow-up ranged from 3 months to 22 years., Results: Two children died several years later due to intractable seizures. Overall, 65% are seizure-free, 21% have occasional, non-handicapping seizures, and 14% have troublesome seizures. Eighty percent are on one anticonvulsant or none and 89% are able to walk without assistance. Etiology strongly predicted seizure outcome. Patients with migrational disorders are less likely to be seizure-free than all other etiologies (predominantly Rasmussen and congenital vascular injuries) combined (51% vs 71%, p = 0.05)., Conclusions: Hemidecortication continues to be a beneficial procedure in reducing seizure frequency in cases of unilateral cortical epilepsy. Fewer children with migrational disorders are seizure-free.
- Published
- 2003
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38. Effect of a high-fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children.
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Kwiterovich PO Jr, Vining EP, Pyzik P, Skolasky R Jr, and Freeman JM
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- Adolescent, Apolipoproteins blood, Child, Child, Preschool, Dietary Fats, Female, Humans, Hyperlipidemias etiology, Infant, Ketosis urine, Lipoproteins blood, Male, Prospective Studies, Diet, Lipids blood, Seizures diet therapy
- Abstract
Context: Little prospective long-term information is available on the effect of a ketogenic diet on plasma lipoproteins in children with difficult-to-control seizures., Objective: To determine the effect in children with intractable seizures of a high-fat ketogenic diet on plasma levels of the major apolipoprotein B (apoB)-containing lipoproteins, low-density lipoprotein (LDL) and very LDL (VLDL); and the major apolipoprotein A-I (apoA-I)-containing lipoprotein, high-density lipoprotein (HDL)., Design, Setting, and Patients: A 6-month prospective cohort study of 141 children (mean [SD] age, 5.2 [3.8] years for 70 boys and 6.1 [4.4] years for 71 girls) with difficult-to-treat seizures who were hospitalized for initiation of a high-fat ketogenic diet and followed up as outpatients. This cohort constituted a subgroup of the 371 patients accepted into the ketogenic diet program between 1994 and 2001. A subset of the cohort was also studied after 12 (n = 59) and 24 (n = 27) months., Intervention: A ketogenic diet consisting of a high ratio of fat to carbohydrate and protein combined (4:1 [n = 102], 3.5:1 [n = 7], or 3:1 [n = 32]). After diet initiation, the calories and ratio were adjusted to maintain ideal body weight for height and maximal urinary ketosis for seizure control., Main Outcome Measures: Differences at baseline and 6-month follow-up for levels of total, VLDL, LDL, HDL, and non-HDL cholesterol; triglycerides; total apoB; and apoA-I., Results: At 6 months, the high-fat ketogenic diet significantly increased the mean plasma levels of total (58 mg/dL [1.50 mmol/L]), LDL (50 mg/dL [1.30 mmol/L]), VLDL (8 mg/dL [0.21 mmol/L]), and non-HDL cholesterol (63 mg/dL [1.63 mmol/L]) (P<.001 vs baseline for each); triglycerides (58 mg/dL [0.66 mmol/L]) (P<.001); and total apoB (49 mg/dL) (P<.001). Mean HDL cholesterol decreased significantly (P<.001), although apoA-I increased (4 mg/dL) (P =.23). Significant but less marked changes persisted in children observed after 12 and 24 months., Conclusions: A high-fat ketogenic diet produced significant increases in the atherogenic apoB-containing lipoproteins and a decrease in the antiatherogenic HDL cholesterol. Further studies are necessary to determine if such a diet adversely affects endothelial vascular function and promotes inflammation and formation of atherosclerotic lesions.
- Published
- 2003
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39. Rational Reduction in Abuse of Neuroimaging.
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Vining EP
- Published
- 2003
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40. Will the Real Temporal Lobe Epilepsy in Childhood Please Stand Up?
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Vining EP
- Published
- 2003
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41. Auditory processing studied prospectively in two hemidecorticectomy patients.
- Author
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Boatman D, Vining EP, Freeman J, and Carson B
- Subjects
- Acoustic Stimulation, Attention, Cerebral Cortex physiopathology, Child, Encephalitis physiopathology, Encephalitis surgery, Female, Humans, Noise, Pitch Discrimination, Prospective Studies, Speech Perception, Auditory Perception, Cerebral Cortex physiology, Functional Laterality, Hemispherectomy
- Abstract
Auditory processing of speech and nonspeech sounds was studied prospectively in two hemidecorticectomy patients (ages 10-11 years) with Rasmussen's syndrome. We tested auditory word recognition under four listening conditions: in quiet, in noise, after acoustic filtering, and dichotically. Recognition of environmental sounds and discrimination of tones and digitized syllables were also tested. Presurgical testing confirmed normal processing of speech and nonspeech, for both patients, under all listening conditon. One year after surgery, both patients demonstrated intact recognition of words and environmental sounds in quiet but impaired word recognition in noise. The left hemidecorticectomy patient also demonstrated impaired recognition of low-pass filtered words. These findings suggest that either hemisphere can process speech or nonspeech sounds in quiet, whereas both hemispheres are needed to process speech in background noise. Hemispheric contributions to processing speech in noise appear to differ, with the left hemisphere compensating for loss of phonologic information and the right hemisphere compensating for increased attention demands.
- Published
- 2003
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42. Growth of children on the ketogenic diet.
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Vining EP, Pyzik P, McGrogan J, Hladky H, Anand A, Kriegler S, and Freeman JM
- Subjects
- Anthropometry, Body Height physiology, Body Weight physiology, Child, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Child Development physiology, Diet, Protein-Restricted, Epilepsy diet therapy, Epilepsy metabolism, Ketone Bodies metabolism
- Abstract
This is a prospective cohort study of 237 children (130 males, 107 females) placed on the ketogenic diet for control of intractable epilepsy (mean age at starting diet 3 years 8 months; age range 2 months to 9 years 10 months); average length of follow-up was 308 days. There were 133 children on the diet at 1 year and 76 at 2 years. Height and weight measurements were converted into age- and sex-appropriate z scores. There was a rapid drop in weight z scores in the first 3 months. After this initial period, the weight z score remained constant in children who started the diet below the median weight for their age and sex, although z scores continued to decrease in children starting above the median. There was a small decrease in height z scores in the first 6 months (<0.5); however, there were larger changes by 2 years. There was no difference based on sex for either height or weight. The ketogenic diet generally provides sufficient nutrition to maintain growth within normal parameters over a defined period. Very young children grow poorly on the diet and should be followed-up carefully over long periods of use.
- Published
- 2002
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43. The postoperative course and management of 106 hemidecortications.
- Author
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Kossoff EH, Vining EP, Pyzik PL, Kriegler S, Min KS, Carson BS, Avellino AM, and Freeman JM
- Subjects
- Adolescent, Adult, Anti-Inflammatory Agents administration & dosage, Bacterial Infections complications, Bacterial Infections diagnosis, Child, Child, Preschool, Dexamethasone administration & dosage, Female, Humans, Infant, Male, Meningitis cerebrospinal fluid, Meningitis complications, Postoperative Period, Retrospective Studies, Spinal Puncture, Treatment Outcome, Ventriculoperitoneal Shunt, Cerebrospinal Fluid microbiology, Fever etiology, Hemispherectomy adverse effects, Hemispherectomy mortality
- Abstract
Rationale: The excellent long-term outcome for most children undergoing hemispherectomy is well documented. However, the condition of these children in the immediate postoperative period is poorly described. The purpose of this study was to evaluate the short-term issues surrounding hemispherectomy and their management in a series of patients from our institution., Methods: 106 hemispherectomies were performed at our institution from 1975 to 2001 (102 hemidecortications). Medical records were retrospectively examined for information regarding immediate postoperative problems and care., Results: Three children died in the immediate perioperative period, while 3 others had significant postoperative morbidity. 82% of these children had postoperative fevers (temperature >38.5 degrees C). Of these children, 62% had lumbar punctures. Ten cases had positive CSF growth, of which 6 cases were felt to have actual meningitis. Patients with CSF growth had a significantly longer prior duration of steroid therapy and higher maximum temperature peaks. CSF pleocytosis and an ill clinical appearance neared significance for prediction of CSF growth. Shunting was performed in 19% of all children and was associated with CSF growth., Conclusions: Postoperative fevers are common after hemidecortication, but meningitis is not. Children with CSF growth tended to appear more ill and have higher temperature spikes and CSF pleocytosis. Shunting was related to CSF growth., (Copyright 2002 S. Karger AG, Basel)
- Published
- 2002
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44. Implication of Status Epilepticus in Childhood Epilepsy.
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Vining EP
- Published
- 2002
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45. Kidney stones, carbonic anhydrase inhibitors, and the ketogenic diet.
- Author
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Kossoff EH, Pyzik PL, Furth SL, Hladky HD, Freeman JM, and Vining EP
- Subjects
- Carbonic Anhydrase Inhibitors adverse effects, Child, Child, Preschool, Cohort Studies, Combined Modality Therapy, Dietary Fats administration & dosage, Female, Food, Formulated, Humans, Incidence, Infant, Ketone Bodies metabolism, Kidney Calculi chemically induced, Kidney Calculi etiology, Male, Retrospective Studies, Risk Factors, Carbonic Anhydrase Inhibitors therapeutic use, Epilepsy diet therapy, Epilepsy drug therapy, Ketosis etiology, Kidney Calculi epidemiology
- Abstract
Purpose: Because carbonic anhydrase inhibitors and the ketogenic diet are each known risk factors for kidney stones, simultaneous use of these therapies has been discouraged. The objective of this study was to establish the prevalence of nephrolithiasis in children in this combination-therapy population., Methods: Since 1996, 301 children have been started on the ketogenic diet at our institution. A retrospective cohort study of renal calculi in ketogenic diet patients was performed to evaluate the increased risk with combined use of a carbonic anhydrase inhibitor., Results: In 15 (6.7%) of 221 children on the ketogenic diet without the use of carbonic anhydrase inhibitors, stones developed. In five (6.3%) of the 80 children on the diet in combination with topiramate or zonisamide, stones developed. There was no difference between these two groups (p = 0.82). No child was treated with either acetazolamide or more than one carbonic anhydrase inhibitor simultaneously. Prior ketogenic diet duration was shorter (10.4 vs. 22.4 months; p = 0.03), and more children had either a family history of renal stones or significant urologic abnormalities (80 vs. 27%; p = 0.04) in the combination-therapy group., Conclusions: The combined use of carbonic anhydrase inhibitors and the ketogenic diet does not increase the risk of kidney stones. We recommend that all patients treated with combination therapy should be treated with increased hydration. Urine alkalinization should be considered for children with previous renal abnormalities, family histories of kidney stones, hematuria, or elevated urine calcium-to-creatinine ratios. If renal stones are found, we advocate discontinuation of the carbonic anhydrase inhibitor.
- Published
- 2002
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46. Efficacy of the ketogenic diet for infantile spasms.
- Author
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Kossoff EH, Pyzik PL, McGrogan JR, Vining EP, and Freeman JM
- Subjects
- Child, Preschool, Dietary Carbohydrates administration & dosage, Dietary Fats administration & dosage, Dietary Proteins administration & dosage, Female, Follow-Up Studies, Humans, Infant, Male, Risk Assessment, Treatment Outcome, Food, Formulated, Ketosis chemically induced, Spasms, Infantile diet therapy
- Abstract
Objective: The objective of this study was to determine whether the ketogenic diet is safe, well-tolerated, and efficacious in the treatment of infantile spasms., Methods: During a 4-year period, 23 children with infantile spasms, aged 5 months to 2 years, were started on the ketogenic diet; 9 (39%) had symptomatic infantile spasms, and 16 (70%) had hypsarrhythmia. Children had an average prediet exposure to 3.3 anticonvulsants. Two children were enrolled before any medication had been tried. Seizure reduction was analyzed retrospectively, using parent reports and electroencephalograms (EEGs) when available., Results: At 3, 6, 9, and 12 months, 38%, 39%, 53%, and 46%, respectively, of all patients currently on the diet were >90% improved (3 were seizure-free at 12 months); 67%, 72%, 93%, and 100% were >50% improved. Fifty-six percent remained on the diet at 12 months, 46% of whom were >90% improved and 100% were >50%. Fifty percent of those with hypsarrhythmia and follow-up EEGs had EEG improvement. Fifty-seven percent had their medications reduced or discontinued by 12 months. Fifty-seven percent had improvement in development, which was correlated with seizure control. Independent factors that predicted improvement included age younger than 1 year and previous exposure to 3 or fewer anticonvulsants. No child has died, and 7 children had diet-related adverse reactions (nephrolithiasis, gastroesophageal reflux)., Discussion: The ketogenic diet is a safe, well-tolerated, and possibly effective potential alternative to other therapies for infantile spasms.
- Published
- 2002
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47. Neonatal hypocalcemic seizures: case report and literature review.
- Author
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Kossoff EH, Silvia MT, Maret A, Carakushansky M, and Vining EP
- Subjects
- Calcium Gluconate blood, Calcium Gluconate therapeutic use, Electroencephalography, Humans, Hypocalcemia drug therapy, Infant, Injections, Intravenous, Male, Hypocalcemia complications, Seizures diagnosis, Seizures etiology
- Abstract
Seizures during the neonatal period have a broad differential diagnosis, many with a specific treatment and prognosis. In the case reported, a combination of dietary and endocrinologic abnormalities resulted in hypocalcemic seizures, which continued despite aggressive correction of serum ionized calcium levels. Serial electroencephalograms (EEG) performed during the hospitalization were markedly abnormal, and treatment with anticonvulsant drugs was considered given the persistence of seizures despite normalization of serum calcium levels. After 4 days of intravenous calcium administration, the seizure activity resolved, and the patient returned to his normal baseline level of functioning. This case highlights the clinical course of neonatal hypocalcemic seizures, EEG findings in several cases, and possible mechanisms for both hypocalcemic precipitation of seizures and anticonvulsant ineffectiveness.
- Published
- 2002
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48. The ketogenic diet.
- Author
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Vining EP
- Subjects
- Child, Dietary Fats therapeutic use, Fasting physiology, Humans, Ketone Bodies metabolism, Ketosis metabolism, Epilepsy diet therapy
- Abstract
One of the most significant trends in therapy has been the renewed popularity of the ketogenic diet. Dr. Vining discusses the history of the diet, its possible mechanisms of action and its clinical efficacy.
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- 2002
- Full Text
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49. Levetiracetam psychosis in children with epilepsy.
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Kossoff EH, Bergey GK, Freeman JM, and Vining EP
- Subjects
- Acute Disease, Adolescent, Anticonvulsants therapeutic use, Child, Preschool, Comorbidity, Drug Administration Schedule, Female, Humans, Learning Disabilities epidemiology, Levetiracetam, Male, Mental Disorders epidemiology, Piracetam therapeutic use, Psychoses, Substance-Induced diagnosis, Psychoses, Substance-Induced epidemiology, Remission, Spontaneous, Anticonvulsants adverse effects, Epilepsy drug therapy, Piracetam adverse effects, Piracetam analogs & derivatives, Psychoses, Substance-Induced etiology
- Abstract
Purpose: Levetiracetam is a new anticonvulsant (AED) with a novel mechanism of action. Although it is generally well tolerated with a good cognitive profile, irritability and hostility have been reported in some adults taking levetiracetam. Observations in children are limited; levetiracetam is not yet approved by the Food and Drug Administration for use in children., Methods: In four young patients, acute psychosis developed within days to months of initiation of levetiracetam for seizures., Results: A 5-year-old girl began having visual hallucinations of spiders in her room 14 days after starting levetiracetam. A 13-year-old boy began having auditory hallucinations, insomnia, and screaming behavior 3 months after initiation of levetiracetam. A 16-year-old girl became acutely agitated, hyperreligious, and had persecutory delusions within 7 days of starting levetiracetam. A 17-year-old girl had auditory hallucinations telling her to sing and yell after 30 days of taking the drug. All four children had dramatic improvement within days of either discontinuing or decreasing the dose of levetiracetam. The three adolescents had historical findings consistent with mild behavioral problems before initiating levetiracetam, and all four patients had prior cognitive deficits., Conclusions: Reversible treatment-emergent psychosis associated with levetiracetam therapy was observed in four children and adolescents. Whether rapid initiation or prior neurobehavioral problems predispose to this side effect is not established.
- Published
- 2001
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50. Effects of ketogenic diet on development and behavior: preliminary report of a prospective study.
- Author
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Pulsifer MB, Gordon JM, Brandt J, Vining EP, and Freeman JM
- Subjects
- Adolescent, Attention, Child, Child Behavior Disorders diagnosis, Child Behavior Disorders psychology, Child, Preschool, Cognition, Developmental Disabilities diagnosis, Developmental Disabilities psychology, Female, Humans, Infant, Male, Parents psychology, Pilot Projects, Prospective Studies, Seizures complications, Seizures metabolism, Social Behavior, Stress, Psychological diagnosis, Stress, Psychological etiology, Stress, Psychological psychology, Child Behavior, Child Behavior Disorders etiology, Child Development, Developmental Disabilities etiology, Ketone Bodies biosynthesis, Seizures diet therapy
- Abstract
The ketogenic diet is increasingly used for the management of difficult-to-control seizures in children. Here, we describe the first prospective study of the effects of the diet on development, behavior, and parenting stress. Participants were 65 children (36 males, 29 females) with intractable seizures, ages 18 months to 14 years 6 months, enrolled in a prospective study at the Johns Hopkins Hospital, Baltimore, MD, USA, to study the diet's efficacy. Children were assessed before diet initiation and at 1-year follow-up. At follow-up, 52% (34 of 65) children remained on the diet. Mean seizure frequency decreased from 25 per day before diet initiation to less than two per day 1 year later. At follow-up, mean developmental quotient showed statistically significant improvement (p<0.05), with significant behavioral improvements in attention and social functioning. Parental stress was essentially unchanged. No baseline factor examined predicted diet adherence, and the primary reason for diet discontinuation was insufficient seizure control. These preliminary results support prior anecdotal reports of the beneficial effects of the diet on cognition and behavior.
- Published
- 2001
- Full Text
- View/download PDF
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