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A blinded, crossover study of the efficacy of the ketogenic diet.
- Source :
-
Epilepsia [Epilepsia] 2009 Feb; Vol. 50 (2), pp. 322-5. Date of Electronic Publication: 2008 Aug 19. - Publication Year :
- 2009
-
Abstract
- Despite over 80 years of use, the ketogenic diet (KD) has never been tested in a blinded manner. Twenty children with intractable Lennox-Gastaut syndrome (LGS) were fasted 36 h and then randomized to receive the classic KD in conjunction with a solution containing either 60 g/day of glucose or saccharin. Parents and physicians were blinded to both the solution composition and level of ketosis. A crossover to the KD with the alternate solution occurred following the sixth day and a repeat fast. A 24-h electroencephalography (EEG) was obtained at baseline and after each arm. After administration of the solution, there was moderate evidence of a reduction in parent-reported seizures between the glucose and saccharin arms, with a median difference of 1.5 seizures per day (p = 0.07). There was no reduction in the number of EEG-identified events, with a median reduction of 7 events per day (p = 0.33). Ketosis was not completely eliminated in the glucose-added arm.
- Subjects :
- 3-Hydroxybutyric Acid urine
Child
Child, Preschool
Cross-Over Studies
Double-Blind Method
Electroencephalography
Epilepsies, Myoclonic urine
Epilepsy, Generalized urine
Female
Glucose Solution, Hypertonic administration & dosage
Humans
Infant
Ketones urine
Male
Saccharin administration & dosage
Syndrome
Diet, Ketogenic
Epilepsies, Myoclonic diet therapy
Epilepsy, Generalized diet therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1528-1167
- Volume :
- 50
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Epilepsia
- Publication Type :
- Academic Journal
- Accession number :
- 18717710
- Full Text :
- https://doi.org/10.1111/j.1528-1167.2008.01740.x