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Your search keyword '"Vine, Alison M."' showing total 9 results
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4. KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection

Author

Seich al Basatena, Nafisa-Katrin, primary, MacNamara, Aidan, additional, Vine, Alison M., additional, Thio, Chloe L., additional, Astemborski, Jacquie, additional, Usuku, Koichiro, additional, Osame, Mitsuhiro, additional, Kirk, Gregory D., additional, Donfield, Sharyne M., additional, Goedert, James J., additional, Bangham, Charles R.M., additional, Carrington, Mary, additional, Khakoo, Salim I., additional, and Asquith, Becca, additional

Published
2011
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5. The Role of CTLs in Persistent Viral Infection: Cytolytic Gene Expression in CD8+ Lymphocytes Distinguishes between Individuals with a High or Low Proviral Load of Human T Cell Lymphotropic Virus Type 1

Author

Vine, Alison M., primary, Heaps, Adrian G., additional, Kaftantzi, Lambrini, additional, Mosley, Angelina, additional, Asquith, Becca, additional, Witkover, Aviva, additional, Thompson, Gillian, additional, Saito, Mineki, additional, Goon, Peter K. C., additional, Carr, Laura, additional, Martinez-Murillo, Francisco, additional, Taylor, Graham P., additional, and Bangham, Charles R. M., additional

Published
2004
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6. The Influence of HLA Class I Alleles and Heterozygosity on the Outcome of Human T Cell Lymphotropic Virus Type I Infection

Author

Jeffery, Katie J. M., primary, Siddiqui, Asna A., additional, Bunce, Mike, additional, Lloyd, Alun L., additional, Vine, Alison M., additional, Witkover, Aviva D., additional, Izumo, Shuji, additional, Usuku, Koichiro, additional, Welsh, Kenneth I., additional, Osame, Mitsuhiro, additional, and Bangham, Charles R. M., additional

Published
2000
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9. KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection.

Author

Al Basatena, Nafisa-Katrin Seich, MacNamara, Aidan, Vine, Alison M., Thio, Chloe L., Astemborski, Jacquie, Usuku, Koichiro, Osame, Mitsuhiro, Kirk, Gregory D., Donfield, Sharyne M., Goedert, James J., Bangham, Charles R. M., Carrington, Mary, Khakoo, Salim I., and Asquith, Becca

Subjects
KILLER cells, CELL receptors, IMMUNITY, T cells, IMMUNE response, VIRUS diseases
Abstract

Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I- restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection. [ABSTRACT FROM AUTHOR]

Published
2011
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