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KIR2DL2 Enhances Protective and Detrimental HLA Class I-Mediated Immunity in Chronic Viral Infection.
- Source :
- PLoS Pathogens; Oct2011, Vol. 7 Issue 10, Special section p1-12, 12p, 1 Diagram, 2 Charts, 3 Graphs
- Publication Year :
- 2011
-
Abstract
- Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I- restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- KILLER cells
CELL receptors
IMMUNITY
T cells
IMMUNE response
VIRUS diseases
Subjects
Details
- Language :
- English
- ISSN :
- 15537366
- Volume :
- 7
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- PLoS Pathogens
- Publication Type :
- Academic Journal
- Accession number :
- 67199899
- Full Text :
- https://doi.org/10.1371/journal.ppat.1002271