Search

Your search keyword '"Vincentini, Olimpia"' showing total 158 results
Start Over Author "Vincentini, Olimpia"
158 results on '"Vincentini, Olimpia"'

2. Follow‐up and monitoring programme in children identified in early‐stage type 1 diabetes during screening in the general population of Italy.

Author

Cherubini, Valentino, Mozzillo, Enza, Iafusco, Dario, Bonfanti, Riccardo, Ripoli, Carlo, Pricci, Flavia, Vincentini, Olimpia, Agrimi, Umberto, Silano, Marco, Ulivi, Francesca, D'Avino, Antonio, Lampasona, Vito, and Bosi, Emanuele

Subjects
TYPE 1 diabetes, MEDICAL screening, CELIAC disease, JUVENILE diseases, PEDIATRICIANS, DIABETIC acidosis, KETOACIDOSIS
Abstract

Aim: To provide guidance for follow‐up and monitoring of children and adolescents identified as positive to islet autoantibodies (IA) in the general population screening for type 1 diabetes (T1D) in Italy. Methods: Detection of IA helps to diagnose pre‐symptomatic T1D, prevent diabetic ketoacidosis (DKA) and identify persons for new therapies to delay symptomatic diabetes. Italy recently became the first country to approve by law a general autoantibody screening program for T1D and celiac disease in all children and adolescents (age 1‐17yr). A pilot study is currently underway in four Italian regions addressing feasibility issues to be used in the scale up to nationwide screening. Meanwhile, a group of experts developed guidance recommendations for follow‐up and monitoring of identified IA positive persons. Results: Ten key components have been identified: establishment of a registry for children and adolescents at risk; close collaboration with the national network of family paediatricians; creation of T1D centers with expertise in follow‐up and monitoring; educational measures; assurance of solid IA tests; identification of appropriate metabolic tests; feed‐back feasibility and acceptability questionnaires; potential access to available therapeutic interventions; valuable outcome measures including DKA incidence; costs monitoring. Distinctive features of this program include single (in addition to multiple) IA antibody‐positive persons in follow‐up and the use of CGM to assess risk progression, rather than the cumbersome OGTT. Conclusion: It is expected that the proposed follow‐up and monitoring program will be effective, affordable and acceptable to children and families identified in general T1D screening in Italy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

3. Proposal for a qualification system for New Approach Methodologies (NAMs) in the food and feed sector: example of implementation for nanomaterial risk assessment.

Author

Haase, Andrea, Barroso, João, Bogni, Alessia, Bremer‐Hoffmann, Susanne, Fessard, Valerie, Gutleb, Arno C., Mast, Jan, McVey, Emily, Mertens, Birgit, Oomen, Agnes G., Ritz, Vera, Serchi, Tommaso, Siewert, Katherina, Stanco, Deborah, Usmani, Shirin M., Verleysen, Eveline, Vincentini, Olimpia, van der Zande, Meike, and Cubadda, Francesco

Subjects
STANDARD operating procedure, CHEMICAL systems, FOOD industry, CYTOTOXINS, RISK assessment
Abstract

Plenty of new approach methodologies (NAMs) for risk assessment have been developed but only some are included in OECD Test Guidelines (TGs) for regulatory implementation. Nevertheless, NAMs are increasingly applied, e.g. for nanomaterial (NM) risk assessments. The EFSA Guidance on NM risk assessment suggests that NAM‐derived data concerning degradation/dissolution (in relevant biofluids), intestinal uptake/crossing, genotoxicity, cytotoxicity, oxidative stress, (pro‐)inflammatory potential and barrier integrity, for many of which no OECD TGs exist, have to be evaluated first. Consequently, NM risk assessments involve data from non‐guideline studies, requiring time‐consuming and challenging case‐by‐case evaluations. Establishing an OECD TG is a formal process aiming for international use according to the Mutual Acceptance of Data (MAD). However, not every promising NAM can be prioritised for OECD TGs. A qualification, based on an expert opinion, may enable an efficient use of adequate NAMs for a specific context‐of‐use. Furthermore, it supports the optimisation of promising NAMs for regulatory applications. Existing qualification systems operate in the context of e.g., drug development tools (FDA) and research and development into pharmaceuticals (EMA). The NAMS4NANO consortium was tasked to propose a generic framework for a qualification system for chemical risk assessment in the food and feed sector to speed up the regulatory use of NAMs. Here we describe our proposal including the process and evaluation criteria. A detailed test method description, preferably as standard operating procedures (SOPs), describing the set‐up of the NAM including its application and evaluation phase is crucial. Furthermore, the scientific validity, i.e. its reliability and relevance for the context‐of‐use, needs to be demonstrated, for which we suggest a less rigorous process compared to OECD TGs. We propose to initially establish a qualification system for NM risk assessment, aligned with the EFSA framework. This document is an interim version to stipulate a broader discussion among experts and stakeholders. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. EFSA Project on the use of New Approach Methodologies (NAMs) for the hazard assessment of nanofibres. Lot 1, nanocellulose oral exposure: gastrointestinal digestion, nanofibres uptake and local effects

Author

Vincentini, Olimpia, primary, Blier, Anne‐Louise, additional, Bogni, Alessia, additional, Brun, Morgane, additional, Cecchetti, Serena, additional, De Battistis, Francesca, additional, Denis, Sylvain, additional, Etienne‐Mesmin, Lucie, additional, Ferraris, Francesca, additional, Fumagalli, Francesco Sirio, additional, Hogeveen, Kevin, additional, Iacoponi, Francesca, additional, Raggi, Andrea, additional, Siciliani, Lisa, additional, Stanco, Deborah, additional, Verleysen, Eveline, additional, Fessard, Valerie, additional, Mast, Jan, additional, Blanquet‐Diot, Stephanie, additional, Bremer‐Hoffmann, Susanne, additional, and Cubadda, Francesco, additional

Published
2023
Full Text
View/download PDF

7. Evaluation of the Potential Anti-Inflammatory Activity of Black Rice in the Framework of Celiac Disease

Author

Piazza, Stefano, primary, Colombo, Francesca, additional, Bani, Corinne, additional, Fumagalli, Marco, additional, Vincentini, Olimpia, additional, Sangiovanni, Enrico, additional, Martinelli, Giulia, additional, Biella, Simone, additional, Silano, Marco, additional, Restani, Patrizia, additional, Dell’Agli, Mario, additional, and Di Lorenzo, Chiara, additional

Published
2022
Full Text
View/download PDF

9. Use of New Approach Methodologies for the hazard assessment of nanocellulose oral exposure: the EFSA granted NANOCELLUP project

Author

Cubadda, Francesco, Tarazona, José, Astuto, Maria-Chiara, Fessard, Valérie, Lehegarat, Ludovic, Hogeveen, Kevin, Mast, Jan, Verleysen, Eveline, Blanquet-Diot, Stéphanie, Etienne-Mesmin, Lucie, Denis, Sylvain, Bremer-Hoffmann, Susanne, Halamoda-Kenzaoui, Blanka, Iacoponi, Francesca, Ferraris, Francesca, Raggi, Andrea, de Battistis, Francesca, Mantovani, Alberto, Vincentini, Olimpia, Microbiologie Environnement Digestif Santé (MEDIS), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience

Published
2022

11. Circulating microRNAs as novel non-invasive biomarkers of paediatric celiac disease and adherence to gluten-free diet

Author

Felli, Cristina, primary, Baldassarre, Antonella, additional, Uva, Paolo, additional, Alisi, Anna, additional, Cangelosi, Davide, additional, Ancinelli, Monica, additional, Caruso, Mariangela, additional, Paolini, Alessandro, additional, Montano, Alessia, additional, Silano, Marco, additional, Vincentini, Olimpia, additional, Catassi, Carlo, additional, Lionetti, Elena, additional, Gatti, Simona, additional, Ferretti, Francesca, additional, and Masotti, Andrea, additional

Published
2022
Full Text
View/download PDF

14. Evaluation of the Potential Anti-Inflammatory Activity of Black Rice in the Framework of Celiac Disease.

Author

Piazza, Stefano, Colombo, Francesca, Bani, Corinne, Fumagalli, Marco, Vincentini, Olimpia, Sangiovanni, Enrico, Martinelli, Giulia, Biella, Simone, Silano, Marco, Restani, Patrizia, Dell'Agli, Mario, and Di Lorenzo, Chiara

Subjects
GLIADINS, CELIAC disease, ANTI-inflammatory agents, RICE, REACTIVE oxygen species, AGGLUTINATION tests, GLUTEN-free foods
Abstract

Inflammation and oxidative stress are two mechanisms involved in the pathogenesis of celiac disease (CD). Since the direct effect of gliadin on the intestinal epithelia is less studied, the aims of this study were the development of a specific cellular model based on the use of gliadin as a pro-inflammatory stimulus and the evaluation of the potential antioxidant and anti-inflammatory properties of extracts from different black rice in the framework of CD. The rice extracts were in vitro digested, characterized in terms of phenolic compounds and antioxidant capacity, and tested on Caco-2 cells to investigate their inhibitory effect on Reactive Oxygen Species, the NF-κB transcription and the CXC chemokines (sICAM-1, IL-8, and CXCL-10). In addition, the role of the extracts in modulating the activation of epithelial cells in CD was confirmed by applying the K562(S) agglutination test. The black rice extracts showed inhibitory effects on the production of the oxidative and the inflammatory mediators considered, with particular reference to lymphocyte-attracting CXCL-10 both before and after digestion. The presence of anthocyanins and their digestion metabolites may account for the observed anti-inflammatory activity after in vitro digestion. This work provided preliminary data supporting the use of black rice as a healthy food or ingredient of food supplements for celiacs. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

15. Towards the Standardization of Intestinal In Vitro Advanced Barrier Model for Nanoparticles Uptake and Crossing: The SiO 2 Case Study.

Author

Vincentini, Olimpia, Prota, Valentina, Cecchetti, Serena, Bertuccini, Lucia, Tinari, Antonella, Iosi, Francesca, and De Angelis, Isabella

Subjects
*INTESTINES, *MUCUS, *STANDARDIZATION, *NANOPARTICLES, *EPITHELIAL cells, *B cells, *RISK assessment
Abstract

Increasing interest is being addressed to the development of a reliable, reproducible and relevant in vitro model of intestinal barrier, mainly for engineered nanomaterials hazard and risk assessment, in order to meet regulatory and scientific demands. Starting from the consolidated Caco-2 cell model, widely used for determining translocation of drugs and chemicals, the establishment of an advanced intestinal barrier model with different level of complexity is important for overcoming Caco-2 monoculture limitations. For this purpose, a tri-culture model, consisting of two human intestinal epithelial cells (Caco-2 and HT29-MTX) and a human lymphocyte B cell (Raji B), was developed by several research groups to mimic the in vivo intestinal epithelium, furnishing appropriate tools for nanotoxicological studies. However, tri-culture model shows high levels of variability in ENM uptake/translocation studies. With the aim of implementing the standardization and optimization of this tri-culture for ENM translocation studies, the present paper intends to identify and discuss such relevant parameters involved in model establishment as: tri-culture condition set-up, barrier integrity evaluation, mucus characterization, M-cell induction. SiO2 fluorescent nanoparticles were used to compare the different models. Although a low level of SiO2 translocation is reported for all the different culture conditions. a relevant role of mucus and M-cells in NPs uptake/translocation has been highlighted. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

23. Megalencephalic Leukoencephalopathy with Subcortical Cysts Disease-Linked MLC1 Protein Favors Gap-Junction Intercellular Communication by Regulating Connexin 43 Trafficking in Astrocytes

Author

Lanciotti, Angela, primary, Brignone, Maria Stefania, additional, Belfiore, Marcello, additional, Columba-Cabezas, Sandra, additional, Mallozzi, Cinzia, additional, Vincentini, Olimpia, additional, Molinari, Paola, additional, Petrucci, Tamara Corinna, additional, Visentin, Sergio, additional, and Ambrosini, Elena, additional

Published
2020
Full Text
View/download PDF

25. Fermented Portulaca oleracea L. Juice: A Novel Functional Beverage with Potential Ameliorating Effects on the Intestinal Inflammation and Epithelial Injury

Author

Cagno, Raffaella Di, Filannino, Pasquale, Vincentini, Olimpia, Cantatore, Vincenzo, Cavoski, Ivana, and Gobbetti, Marco

Subjects
lactic acid bacteria, antioxidant, intestinal inflammation, food and beverages, Portulaca oleracea, lcsh:TX341-641, functional beverage, lcsh:Nutrition. Foods and food supply, anti-inflammatory
Abstract

P. oleracea L. contains high level of nutrients and biologically active compounds. Recently, lactic fermentation has been proposed as a biotechnological option to enrich the profile of biogenic compounds of Portulaca oleracea L. puree. This study investigated the capability of fermentation by selected lactic acid bacteria to enhance the restoring features of Portulaca oleracea juice towards intestinal inflammation and epithelial injury. Lactic acid fermentation markedly increased the total antioxidant capacity of P. oleracea juice, preserved the inherent levels of vitamins C, A, and E, and increased the bioavailability of the level of vitamin B2 and that of phenolics. The effects of fermented P. oleracea juice on a Caco-2 cell line were investigated using an in vitro model closest to the in vivo conditions. Fermented P. oleracea juice strongly decreased the levels of pro-inflammatory mediators and reactive oxygen species. It also counteracted the disruption of the Caco-2 cell monolayers treated with the inflammatory stimulus. We used a diversified spectrum of lactic acid bacteria species, and some effects appeared to be strains- or species-specific. Fermentation with Lactobacillus kunkeei B7 ensured the best combination for the content of bioactive compounds and the ability to counteract the intestinal inflammation and epithelial injury.

Published
2019

31. Low risk of colon cancer in patients with celiac disease

Author

Volta, Umberto, Vincentini, Olimpia, Quintarelli, Federica, Felli, Cristina, Silano, Marco, Gasbarrini, G, De Vitis, V, Santini, D, Scaggiante, F, Castellano, E, Grosso, S, Campanella, J, Corazza, GR, Sandri, G, Giorgetti, G, Caio, G, Lo Perfido, S, Perri F, Festa V, Pelli MA, Cavalletti ML, Segato S, Curzio M, Pennazio M, Rossini FP, Picarelli A, Pera A, Ercole E, Passaleva MT, Barbato M, Usai P, Dore MF, Chilovi F, Piazzi L, Zancanella L, Boarino V, Ferrari A., GRECO, LUIGI, AURICCHIO, SALVATORE, Volta, Umberto, Vincentini, Olimpia, Quintarelli, Federica, Felli, Cristina, Silano, Marco, Gasbarrini, G, De Vitis, V, Greco, Luigi, Auricchio, Salvatore, Santini, D, Scaggiante, F, Castellano, E, Grosso, S, Campanella, J, Corazza, Gr, Sandri, G, Giorgetti, G, Caio, G, Lo, Perfido, S, Perri, F, Festa, V, Pelli, Ma, Cavalletti, Ml, Segato, S, Curzio, M, Pennazio, M, Rossini, Fp, Picarelli, A, Pera, A, Ercole, E, Passaleva, Mt, Barbato, M, Usai, P, Dore, Mf, Chilovi, F, Piazzi, L, Zancanella, L, Boarino, V, Ferrari, A., Volta U, Vincentini O, Quintarelli F, Felli C, Silano M, and Collaborating Centres of the Italian Registry of the Complications of Celiac Disease

Subjects
Male, Colorectal cancer, COLON CANCER, Disease, Gastroenterology, Colon carcinoma, Retrospective Studie, Medicine, Child, Colonic Neoplasm, education.field_of_study, Medicine (all), Incidence, Celiac disease, Gluten-free diet, Adolescent, Adult, Carcinoma, Celiac Disease, Child, Preschool, Colonic Neoplasms, Diet, Gluten-Free, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Italy, Middle Aged, Patient Compliance, Retrospective Studies, Risk Assessment, Young Adult, Population study, Human, Cohort study, medicine.medical_specialty, Population, Follow-Up Studie, NO, Internal medicine, In patient, Preschool, education, business.industry, Newborn, medicine.disease, digestive system diseases, Diet, Standardized mortality ratio, Gluten-Free, Celiac disease, colon carcinoma, gluten-free diet, business
Abstract

Objective. Celiac disease (CD) has strongly been established as associated with some site-specific gastrointestinal malignancies. On the contrary, according to the few reports available, the risk of colon carcinoma in CD patients has been described similar to that of general population. In this cohort study, we describe the risk of colon carcinoma in a group of Italian celiac patients. Materials and methods. The study population included all CD patients diagnosed at the Collaborating Centers of the Italian Registry of CD between 1st January 1982 and 31st December 2006. Upon diagnosis of CD and upon at every subsequent clinical control, the Collaborating Centers filled in a validated form for each CD patient reporting information about demographic data, possible occurrence of a neoplasm and adherence to a gluten-free diet. Results. Out of 1757 celiac patients enrolled, 6 developed a colon carcinoma during the follow-up period (mean: 18.1 years). The standardized incidence ratio (SIR) resulted 0.29 (95% CI = 0.07–0.45). Stratifying the risk for the dietary gluten intake, the SIR dropped to 0.07 (95% CI = 0.009–0.27) for CD patients with a strict adherence to a gluten-free diet. Conclusion. We confirm the previous finding that there is low risk to develop a colon cancer in celiac patients.

Published
2014

50. Quorum sensing in sourdough Lactobacillus plantarum DC400: Induction of plantaricin A (PlnA) under co‐cultivation with other lactic acid bacteria and effect of PlnA on bacterial and Caco‐2 cells

Author

Di Cagno, Raffaella, primary, De Angelis, Maria, additional, Calasso, Maria, additional, Vincentini, Olimpia, additional, Vernocchi, Pamela, additional, Ndagijimana, Maurice, additional, De Vincenzi, Massimo, additional, Dessì, Maria Rita, additional, Guerzoni, Maria Elisabetta, additional, and Gobbetti, Marco, additional

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results