Back to Search
Start Over
Low risk of colon cancer in patients with celiac disease
- Publication Year :
- 2014
-
Abstract
- Objective. Celiac disease (CD) has strongly been established as associated with some site-specific gastrointestinal malignancies. On the contrary, according to the few reports available, the risk of colon carcinoma in CD patients has been described similar to that of general population. In this cohort study, we describe the risk of colon carcinoma in a group of Italian celiac patients. Materials and methods. The study population included all CD patients diagnosed at the Collaborating Centers of the Italian Registry of CD between 1st January 1982 and 31st December 2006. Upon diagnosis of CD and upon at every subsequent clinical control, the Collaborating Centers filled in a validated form for each CD patient reporting information about demographic data, possible occurrence of a neoplasm and adherence to a gluten-free diet. Results. Out of 1757 celiac patients enrolled, 6 developed a colon carcinoma during the follow-up period (mean: 18.1 years). The standardized incidence ratio (SIR) resulted 0.29 (95% CI = 0.07–0.45). Stratifying the risk for the dietary gluten intake, the SIR dropped to 0.07 (95% CI = 0.009–0.27) for CD patients with a strict adherence to a gluten-free diet. Conclusion. We confirm the previous finding that there is low risk to develop a colon cancer in celiac patients.
- Subjects :
- Male
Colorectal cancer
COLON CANCER
Disease
Gastroenterology
Colon carcinoma
Retrospective Studie
Medicine
Child
Colonic Neoplasm
education.field_of_study
Medicine (all)
Incidence
Celiac disease
Gluten-free diet
Adolescent
Adult
Carcinoma
Celiac Disease
Child, Preschool
Colonic Neoplasms
Diet, Gluten-Free
Female
Follow-Up Studies
Humans
Infant
Infant, Newborn
Italy
Middle Aged
Patient Compliance
Retrospective Studies
Risk Assessment
Young Adult
Population study
Human
Cohort study
medicine.medical_specialty
Population
Follow-Up Studie
NO
Internal medicine
In patient
Preschool
education
business.industry
Newborn
medicine.disease
digestive system diseases
Diet
Standardized mortality ratio
Gluten-Free
Celiac disease, colon carcinoma, gluten-free diet
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f0ed4ac1c793c48ee0932fd15ed27774