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1. Microdosimetry and radiolytic species production in UHDR proton beam using GATE and Geant4-DNA

Author

Giovanna Rosa Fois, Guillaume Blain, Sophie Chiavassa, Grégory Delpon, Manon Evin, Vincent Fiegel, Mohammad Ghalei, Ferid Haddad, Incerti, S., Charbel Koumeir, Vincent Métivier, Quentin Mouchard, Freddy Poirier, Vincent Potiron, Noël Servagent, Stéphane Supiot, Hoang Ngoc Tran, Johan Vandenborre, Lydia Maigne, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de Physique des Deux Infinis Bordeaux (LP2I - Bordeaux), Université de Bordeaux (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Financial support from Inserm Cancer (PCSI FLASHMOD), Giovanni Mettivier, Sébastien Incerti, Jeremy Brown, Susanna Guatelli, Paolo Russo, Antonio Sarno, Daniele Esposito, Gianfranco Paternò, Silvio Pardi, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
UHDR proton beam, Geant4-DNA, GATE, Microdosimetry, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], radiolytic species, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2022

2. Hydrogen peroxide formation to investigate the radiolytic ROS production mechanism under proton FLASH conditions

Author

Vincent Fiegel, Guillaume Blain, Manon Evin, Quentin Mouchard, Charbel Koumeir, Noël Servagent, Mohammad Ghalei, Giovanna Rosa Fois, Vincent Métivier, Freddy Poirier, Vincent Potiron, Stéphane Supiot, Ferid Haddad, Grégory Delpon, Sophie Chiavassa, Johan Vandenborre, Lydia Maigne, Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Financial support from Inserm Cancer (PCSI FLASHMOD), GdR MI2B, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
FLASHMOD project, Ultra-High Dose Rate, FLASH conditions, [SDV.CAN]Life Sciences [q-bio]/Cancer, ARRONAX cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2022

3. Proton Irradiations at Ultra-High Dose Rate vs. Conventional Dose Rate: Strong Impact on Hydrogen Peroxide Yield

Author

Guillaume Blain, Johan Vandenborre, Daphnée Villoing, Vincent Fiegel, Giovanna Rosa Fois, Ferid Haddad, Charbel Koumeir, Lydia Maigne, Vincent Métivier, Freddy Poirier, Vincent Potiron, Stéphane Supiot, Noël Servagent, Grégory Delpon, Sophie Chiavassa, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
Radiation, Radiochemistry, Hydroxyl Radical, Biophysics, Water, Radiology, Nuclear Medicine and imaging, Hydrogen Peroxide, Protons, [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience; During ultra-high dose rate (UHDR) external radiation therapy, healthy tissues appear to be spared while tumor control remains the same compared to conventional dose rate. However, the understanding of radiochemical and biological mechanisms involved are still to be discussed. This study shows how the hydrogen peroxide (H2O2) production, one of the reactive oxygen species (ROS), could be controlled by early heterogenous radiolysis processes in water during UHDR proton-beam irradiations. Pure water was irradiated in the plateau region (track-segment) with 68 MeV protons under conventional (0.2 Gy/s) and several UHDR conditions (40 Gy/s to 60 kGy/s) at the ARRONAX cyclotron. Production of H2O2 was then monitored using the Ghormley triiodide method. New values of GTS(H2O2) were added in conventional dose rate. A substantial decrease in H2O2 production was observed from 0.2 to 1.5 kGy/s with a more dramatic decrease below 100 Gy/s. At higher dose rate, up to 60 kGy/s, the H2O2 production stayed stable with a mean decrease of 38% ± 4%. This finding, associated to the decrease in the production of hydroxyl radical (•OH) already observed in other studies in similar conditions can be explained by the well-known spur theory in radiation chemistry. Thus, a two-step FLASH-RT mechanism can be envisioned: an early step at the microsecond scale mainly controlled by heterogenous radiolysis, and a second, slower, dominated by O2 depletion and biochemical processes. To validate this hypothesis, more measurements of radiolytic species will soon be performed, including radicals and associated lifetimes.

Published
2022
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5. Technical note: Proton beam dosimetry at ultra-high dose rates (FLASH): Evaluation of GAFchromic™ (EBT3, EBT-XD) and OrthoChromic (OC-1) film performances

Author

Daphnée Villoing, Charbel Koumeir, Arthur Bongrand, Arnaud Guertin, Ferid Haddad, Vincent Métivier, Freddy Poirier, Vincent Potiron, Noël Servagent, Stéphane Supiot, Grégory Delpon, and Sophie Chiavassa

Subjects
Film Dosimetry, Calibration, Proton Therapy, General Medicine, Protons, Radiometry
Abstract

The ARRONAX cyclotron facility offers the possibility to deliver proton beams from low to ultra-high dose rates (UHDR). As a good control of the dosimetry is a prerequisite of UHDR experimentations, we evaluated in different conditions the usability and the dose rate dependency of several radiochromic films commonly used for dosimetry in radiotherapy.We compared the dose rate dependency of three types of radiochromic films: GAFchromic™ EBT3 and GAFchromic™ EBT-XD (Ashland Inc., Wayne, NJ, USA), and OrthoChromic OC-1 (OrthoChrome Inc., Hillsborough, NJ, USA), after proton irradiations at various mean dose rates (0.25, 40, 1500, and 7500 Gy/s) and for 10 doses (2-130 Gy). We also evaluated the dose rate dependency of each film considering beam structures, from single pulse to multiple pulses with various frequencies.EBT3 and EBT-XD films showed differences of response between conventional (0.25 Gy/s) and UHDR (7500 Gy/s) conditions, above 10 Gy. On the contrary, OC-1 films did not present overall difference of response for doses except below 3 Gy. We observed an increase of the netOD with the mean dose rate for EBT3 and EBT-XD films. OC-1 films did not show any impact of the mean dose rate up to 7500 Gy/s, above 3 Gy. No difference was found based on the beam structure, for all three types of films.EBT3 and EBT-XD radiochromic films should be used with caution for the dosimetry of UHDR proton beams over 10 Gy. Their overresponse, which increases with mean dose rate and dose, could lead to non-negligible overestimations of the absolute dose. OC-1 films are dose rate independent up to 7500 Gy/s in proton beams. Films response is not impacted by the beam structure. A broader investigation of the usability of OC-1 films in UHDR conditions should be conducted at intermediate and higher mean dose rates and other beam energies.

Published
2021

6. A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam

Author

Daphnée Villoing, Sophie Chiavassa, Arthur Bongrand, Arnaud Guertin, Gregory Delpon, Vincent Potiron, Stéphane Supiot, Ferid Haddad, Noël Servagent, Charbel Koumeir, Freddy Poirier, Vincent Métivier, Cyclotron ARRONAX, GIP, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
[PHYS]Physics [physics], Cancer Research, Range (particle radiation), Materials science, Proton, Nuclear engineering, Monte Carlo method, Context (language use), dose calculation, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Tumor response, lcsh:RC254-282, Article, 030218 nuclear medicine & medical imaging, radiation dosimetry, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Absorbed dose, proton therapy, preclinical studies, Proton therapy, Beam (structure), Monte Carlo simulation
Abstract

Simple Summary If reference studies can be found on the uncertainties linked to the clinical context of proton therapy, they, although equally critical, are very patchy in a preclinical context, and are specific to each beam line. This work provides the community with a complete assessment of the sources of uncertainties for a preclinical proton beam line. This aims to ensure that, in this line, the biological results observed and the dose–response relationships are obtained without any bias. Despite being specific to a preclinical line, the results presented here can be transposed to other types of proton preclinical facilities, and thus allow us to effectively compare them to one another. Abstract Proton therapy (PRT) is an irradiation technique that aims at limiting normal tissue damage while maintaining the tumor response. To study its specificities, the ARRONAX cyclotron is currently developing a preclinical structure compatible with biological experiments. A prerequisite is to identify and control uncertainties on the ARRONAX beamline, which can lead to significant biases in the observed biological results and dose–response relationships, as for any facility. This paper summarizes and quantifies the impact of uncertainty on proton range, absorbed dose, and dose homogeneity in a preclinical context of cell or small animal irradiation on the Bragg curve, using Monte Carlo simulations. All possible sources of uncertainty were investigated and discussed independently. Those with a significant impact were identified, and protocols were established to reduce their consequences. Overall, the uncertainties evaluated were similar to those from clinical practice and are considered compatible with the performance of radiobiological experiments, as well as the study of dose–response relationships on this proton beam. Another conclusion of this study is that Monte Carlo simulations can be used to help build preclinical lines in other setups.

Published
2021
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7. Bremsstrahlung X-rays as a non-invasive tool for ion beam monitoring

Author

Quentin Mouchard, Noël Servagent, Ferid Haddad, Arnaud Guertin, Vincent Métivier, F. Ralite, Charbel Koumeir, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Cyclotron ARRONAX, and GIP

Subjects
Nuclear and High Energy Physics, Materials science, Ion beam, Astrophysics::High Energy Astrophysical Phenomena, Physics::Medical Physics, Ion beam monitoring, Signal, 030218 nuclear medicine & medical imaging, Ion, 03 medical and health sciences, 0302 clinical medicine, Optics, Dosimetry, X-rays, Irradiation, Nuclear Experiment, Instrumentation, [PHYS]Physics [physics], business.industry, Non invasive, Bremsstrahlung, Radiobiology, Bremssstrahlung, 030220 oncology & carcinogenesis, Physics::Accelerator Physics, business, Sensitivity (electronics), Beam (structure)
Abstract

International audience; Non-invasive beam monitoring tools are required to guarantee the delivered dose during ion irradiation. Measuring bremsstrahlung X-rays emitted directly from the irradiated medium is a promising approach. This work presents the feasibility of the method for different incident particles with different energies. A PMMA target was bombarded with helium ions of 68 MeV and protons beams of 30, 40, and 50 MeV. The bremsstrahlung signal, measured with a SDD, was in the magnitude of 10 4 X-rays/nC, indicating the significant sensitivity of the method. A good agreement was found (

Published
2021
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8. Ultra-fast prompt gamma detection in single proton counting regime for range monitoring in particle therapy

Author

Jayde Livingstone, Vincent Métivier, Denis Dauvergne, Jean Michel Létang, Etienne Testa, Charbel Koumeir, M. Yamouni, J-Y. Hostachy, Sara Marcatili, Jean-François Muraz, M.L. Gallin-Martel, L. Gallin-Martel, S. Curtoni, J. Collot, Noël Servagent, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Cyclotron ARRONAX, GIP, Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), HEP, INSPIRE, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université de Nantes - Faculté des Sciences et des Techniques, and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics - Instrumentation and Detectors, Proton, Physics::Instrumentation and Detectors, medicine.medical_treatment, FOS: Physical sciences, Particle detector, 030218 nuclear medicine & medical imaging, [PHYS] Physics [physics], 03 medical and health sciences, 0302 clinical medicine, Optics, Hodoscope, medicine, Proton Therapy, Humans, Radiology, Nuclear Medicine and imaging, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physics, [PHYS]Physics [physics], Range (particle radiation), Particle therapy, Radiological and Ultrasound Technology, business.industry, Phantoms, Imaging, Detector, Gamma ray, Instrumentation and Detectors (physics.ins-det), Physics - Medical Physics, 3. Good health, Time of flight, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Gamma Rays, 030220 oncology & carcinogenesis, Medical Physics (physics.med-ph), business, Monte Carlo Method
Abstract

In order to fully exploit the ballistic potential of particle therapy, we propose an online range monitoring concept based on high-resolution Time-Of-Flight (TOF)-resolved Prompt Gamma (PG) detection in a single proton counting regime. In a proof of principle experiment, different types of monolithic scintillating gamma detectors are read in time coincidence with a diamond-based beam hodoscope, in order to build TOF spectra of PG generated in a heterogeneous target presenting an air cavity of variable thickness. Since the measurement was carried out at low beam currents ($, Comment: 17 pages, 18 figures

Published
2020
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9. Thick multi-layers analysis using high energy PIXE

Author

Alexandre Subercaze, Noël Servagent, Ferid Haddad, Arnaud Guertin, Charbel Koumeir, Vincent Métivier, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
010302 applied physics, Nuclear and High Energy Physics, High energy, Ion beam analysis, Materials science, Cyclotron, Analytical chemistry, Multi-layers, 010403 inorganic & nuclear chemistry, 01 natural sciences, 0104 chemical sciences, law.invention, High energy PIXE, law, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Instrumentation
Abstract

A method for multi-layer analysis using high energy PIXE is described. It is based on the variation of the K α K β ratio as a function of the detection angle. Experiments have been carried out at the ARRONAX cyclotron using 70 MeV protons in order to validate this method. The thicknesses and the sequences of simple multi-layers targets and more complex targets with hidden layers have been determined using this method.

Published
2017
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10. Medical applications of diamond detectors: online control of Hadrontherapy with fast timing and Microbeam Radiation Therapy monitoring

Author

Denis Dauvergne, Abbassi, L., Jean-François Adam, Bes, A., Bosson, G., Collot, J., Crozes, T., Curtoni, S., Gallin-Martel, L., L Gallin-Martel, M., Ghimouz, A., Ferid Haddad, Charbel Koumeir, Lacoste, A., Jean Michel Létang, Jayde Livingstone, Marcatili, S., Vincent Métivier, F Motte, J., F Muraz, J., Rarbi, F. E., Rossetto, O., Rosuel, N., Noël Servagent, É, Testa, Tribouilloy, L., Yamouni, M., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Nanofab (Nanofab ), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Synchrotron Radiation for Biomedicine Laboratory (STROBE), ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics::Instrumentation and Detectors, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

International audience; This presentation will focus on two applications of diamond detectors in the field of innovative radiotherapies.The first one consists of a beam hodoscope for hadrontherapy (proton or carbon ion beams). This detector will be used for position and time stamp of the incident particle beam, in order to detect secondary particles (mainly prompt-gammas). Time of Flight is used to reduce background from massive particles, and select photons issued from the patient only. This detector will be made of a mosaic assembly of several diamond plates with double-side strip metallization. The electronic readout design will enable high count rate and high time resolution of the detector.Preliminary measurements were performed at ARRONAX with 68 MeV protons. Detection efficiency was measured with mono- and polycrystalline diamond detectors. For the latter, up to 95% efficiency (corrected from noise triggering) was obtained for single-proton detection. The time resolution was close to 100ps rms for prompt gamma detection using diamond and fast scintillators for incoming particles and secondary photon detection, respectively. The potential for ultra-fast timing in prompt gamma imaging leads to spatial discrimination and real time reconstruction capabilities for range verification during treatment.The second application consists in the in vivo monitoring of Microbeam Radiation Therapy. The beam is spatially fractionated with local doses above 1000 Gy/s delivered in narrow peaks of a few tens of μm, separated by 300-500μm. A large area diamond detector with 1D position readout by fast- and high-dynamics charge integration will be used to monitor the transmitted photon beam, and thus evaluate the energy deposited in the patient.

Published
2019

11. Investigation of energy dependance for EBT3 response to irradiation with alpha beams

Author

C. Le Deroff, Gregory Delpon, Charbel Koumeir, F. Haddad, Arnaud Guertin, A. M. Frelin, F. Poirier, Noël Servagent, A. Basset, Sophie Chiavassa, Nathalie Michel, Vincent Métivier, Nicolas Varmenot, Cyclotron ARRONAX, GIP, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique)

Subjects
[PHYS]Physics [physics], Nuclear and High Energy Physics, Range (particle radiation), Materials science, Cyclotron, Bragg peak, 030218 nuclear medicine & medical imaging, law.invention, Ionizing radiation, 03 medical and health sciences, 0302 clinical medicine, Stack (abstract data type), law, 030220 oncology & carcinogenesis, Dosimetry, Physics::Accelerator Physics, Irradiation, Atomic physics, Instrumentation, Beam (structure)
Abstract

International audience; The response of EBT3 radiochromic film to ionizing radiation has been investigated for alpha beams. An experiment has been performed at the ARRONAX cyclotron to measure the net optical density (net OD) of EBT3 films as a function of the deposited doses of an alpha beam at different energies. A stack of 4 films was irradiated, therefore the beam energy is changed as a function of the film position between 45 MeV and 22 MeV. No differences in the film responses were observed in function of the alpha beam energy. The same calibration (Dose vs net OD) can be used for EBT3 film in this range of alpha beam energy. It is necessary to extend this study at lower energy down to the Bragg peak region.

Published
2019
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12. THE RADIOBIOLOGICAL PLATFORM AT ARRONAX

Author

Sébastien Gouard, Nathalie Michel, Nicolas Varmenot, Arnaud Guertin, Noël Servagent, Michel Chérel, Eric Garrido, Vincent Métivier, Viviana De Nadal, Roberto Cherubini, Thomas Sounalet, Freddy Poirier, Ferid Haddad, Charbel Koumeir, GIPARRONAX [Saint-Herblain, France], Laboratori Nazionali di Legnaro (LNL), Istituto Nazionale di Fisica Nucleare (INFN), Nuclear Oncology (CRCINA-ÉQUIPE 13), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, This project is partially supported by the ‘Agence National de la Recherche’, called ‘Investissements d’Avenir’, Equipex ArronaxPlus n° ANR-11-EQPX-0004., ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), Bernardo, Elizabeth, Nucléaire pour la Santé - - ARRONAXPLUS2011 - ANR-11-EQPX-0004 - EQPX - VALID, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique)

Subjects
[PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], Cyclotron, [SDV.CAN]Life Sciences [q-bio]/Cancer, Radiation, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 030218 nuclear medicine & medical imaging, law.invention, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, law, Humans, Radiology, Nuclear Medicine and imaging, Irradiation, Physics, Range (particle radiation), [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Radiological and Ultrasound Technology, Public Health, Environmental and Occupational Health, Radiobiology, General Medicine, Alpha particle, Equipment Design, V79 cells, Cyclotrons, Charged particle, Beamline, 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], France
Abstract

International audience; The cyclotron ARRONAX can deliver different types of particles (protons, deuterons, alpha-particles) in an energy range up to 68 MeV. One of its six experimental halls is dedicated to studying the interactions of radiation with matter including living matter. A horizontal beamline for cell irradiation has been setup and characterized. The radiobiological characterization was done in terms of V79 cells survival after irradiation with 68 MeV protons. The results demonstrate that radiobiological studies can be successfully performed confirming the high potential of the facility.

Published
2018
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13. Production of innovative radionuclides for therapy and diagnostics: nuclear data measurements and comparisons with TALYS code

Author

Guertin, A., Nigron, E., Sitarz, M., Duchemin, C., Haddad, F., Vincent Métivier, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Cyclotron ARRONAX, GIP, Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Cyclotron ARRONAX [Saint-Herblain], ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), University of Warsaw (UW), ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011)

Subjects
[PHYS]Physics [physics], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Other
Abstract

International audience; Nuclear medicine is a specialty that uses radioactive nuclei for therapy or diagnostic of diseases such as different types of cancer. The aim of this paper is to give the status of nuclear data collected for medical isotopes production and to present the large set of experimental data collected by the PRISMA team of the Subatech laboratory using the protons, deuterons and alpha particles delivered by the ARRONAX cyclotron from few MeV up to 70 MeV and covering a wide range of target masses. Using these data, we will also show that constrains can be put on simulation tools such as the TALYS code (version 1.9) and compare with TENDL-2015, the TALYS-based evaluated nuclear data library. A better overall agreement with our experimental data could be obtained with a different combination of models already included in the code. 1 Introduction Our research activities are focused on radionuclide production mainly for medical applications, either for therapy or diagnosis. This work is carried out in close collaboration with the GIP ARRONAX that possesses a high energy and high intensity multi-particle cyclotron [1]. In this frame, production cross sections and thick target yields were measured for alpha emitters, such as the U-230/Th-226, Th-227/Ra-223 and Ac-225/Bi-213 generators [2]; for photon, Tc-99m [2], and positon, Sc-44g [3], emitters for diagnosis; for electron emitters Re-186g [4], Tb-155 [5] and Sn-117m [6] for therapeutic applications. From the irradiated materials, new experimental production cross section data of interest for medical applications and monitor reactions have been extracted which allow to expand our knowledge on these excitation functions, to confirm the existing trends and to give additional values on a wider energy range. These experiments were conducted at the ARRONAX facility using the stacked-foil technique. This data set only represents a small part of the data needed in the field studying the production of innovative radionuclides for medical applications. In order to get answers quickly without the need of new experiments, it is interesting to use theoretical models. The TALYS code gather together several of such models for each step of a nuclear interaction. A systematic comparison of our results with the output of the TENDL-2015 nuclear data library and TALYS code (version 1.9) has been done. In this latter case, several combinations of models have been tested in order to better reproduce the available data.

Published
2018

14. High energy PIXE: A tool to characterize multi-layer thick samples

Author

Charbel Koumeir, Arnaud Guertin, Ferid Haddad, Alexandre Subercaze, Vincent Métivier, Noël Servagent, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
Nuclear and High Energy Physics, High energy, Materials science, Sample (material), 010401 analytical chemistry, Cyclotron, Mineralogy, 010403 inorganic & nuclear chemistry, 01 natural sciences, 0104 chemical sciences, Computational physics, law.invention, law, 11. Sustainability, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Instrumentation, Multi layer
Abstract

International audience; High energy PIXE is a useful and non-destructive tool to characterize multi-layer thick samples such as cultural heritage objects. In a previous work, we demonstrated the possibility to perform quantitative analysis of simple multi-layer samples using high energy PIXE, without any assumption on their composition. In this work an in-depth study of the parameters involved in the method previously published is proposed. Its extension to more complex samples with a repeated layer is also presented. Experiments have been performed at the ARRONAX cyclotron using 68 MeV protons. The thicknesses and sequences of a multi-layer sample including two different layers of the same element have been determined. Performances and limits of this method are presented and discussed.

Published
2018
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15. New beam monitoring tool for radiobiology experiments at the cyclotron ARRONAX

Author

L. Schwob, Noël Servagent, Michel Chérel, Ferid Haddad, A. Rahmani, Nicolas Varmenot, Freddy Poirier, Arnaud Guertin, Charbel Koumeir, Vincent Métivier, Nathalie Michel, Centre de Recherche en Cancérologie / Nantes - Angers (CRCNA), Centre hospitalier universitaire de Nantes (CHU Nantes)-Faculté de Médecine d'Angers-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS)-Hôpital Laennec-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôtel-Dieu de Nantes, ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), and UNICANCER

Subjects
Radiobiology, Cyclotron, [SDV.CAN]Life Sciences [q-bio]/Cancer, Electromagnetic radiation, Spectral line, law.invention, Nuclear magnetic resonance, law, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Polymethyl Methacrylate, Computer Simulation, Radiology, Nuclear Medicine and imaging, Saturation (magnetic), ComputingMilieux_MISCELLANEOUS, Photons, Radiation, Radiological and Ultrasound Technology, Radiotherapy Planning, Computer-Assisted, X-Rays, Public Health, Environmental and Occupational Health, Bremsstrahlung, General Medicine, Alpha particle, Cyclotrons, Models, Theoretical, Alpha Particles, Charged particle, Computational physics, Monte Carlo Method
Abstract

International audience; The ARRONAX cyclotron is able to deliver alpha particles at 68 MeV. In the frame of radiological research, a new method is studied to infer in situ the deposited dose: it is based on the online measurement of the bremsstrahlung (>1 keV) produced by the interaction of the incident particle with the medium. Experiments are made using bombarded poly(methyl methacrylate) (PMMA)-equivalent water targets in order to characterise this continuous X-ray spectrum. The intensity of the bremsstrahlung spectrum allows for the beam monitoring. A simulation code of the bremsstrahlung has been built, and a good agreement is found with the experimental spectra. With this simulation, it is possible to predict the sensibility of this method: it varies with the target thickness, showing a good sensibility for thin target (

Published
2015
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16. Monitoring saltwater intrusion in Rupert Bay, Québec, Canada, after the partial diversion of a major tributary

Author

Vincent Métivier, Pierre Dupuis, Alain Tremblay, and Bernard Massicotte

Subjects
Saltwater intrusion, Freshwater inflow, Monitoring, 0208 environmental biotechnology, 02 engineering and technology, Management, Monitoring, Policy and Law, Article, Rivers, Hydroelectricity, Tributary, Environmental monitoring, Seawater, Environmental impact assessment, General Environmental Science, Hydrology, geography, geography.geographical_feature_category, Quebec, Authorization, River diversion, General Medicine, Pollution, 020801 environmental engineering, Bays, Hydrodynamics, Environmental science, Ice cover, Bay, Environmental Monitoring, Power Plants
Abstract

As part of a large hydroelectric project in northern Québec (Canada), a portion of the flow of the Rupert River was diverted toward the existing La Grande hydroelectric complex. As a result of the partial diversion, the discharge of the Rupert River at its mouth is reduced by an average of 50% annually. This corresponds to an 18% decrease in the total freshwater inflow into the bay and, thus, to a shift of the upstream limit of the saltwater intrusion in Rupert Bay. Changes in saltwater intrusion had been predicted numerically as part of the project’s environmental impact assessment (EIA). In the project’s conditions of authorization, monitoring the hydraulic conditions and the extent of saltwater intrusion in the Rupert Bay was required by government authorities. The objective of this paper is to present the results of this environmental monitoring and, more specifically, to validate the modifications predicted in the EIA in terms of both saltwater intrusion limit and hydraulic conditions in the Rupert Bay. Results obtained during 2 years of monitoring are within the predicted trends and order of magnitude of changes anticipated in the EIA. The results, thus, confirm that the shift of the upstream limit of the saltwater front along the channels of the bay was conservatively predicted by numerical modeling.

Published
2017
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17. How nuclear data collected for medical radionuclides production could constrain nuclear codes

Author

Charlotte Remy, C. Duchemin, Arnaud Fardin, Etienne Nigron, Arnaud Guertin, Ferid Haddad, Corentin Guigot, Vincent Métivier, Nathalie Michel, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Accélérateur pour la Recherche en Radiochimie et Oncologie [Nantes Atlantique] (GIP ARRONAX), Université de Nantes (UN)-Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER-UNICANCER-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011)

Subjects
Physics, Range (particle radiation), Radionuclide, Photon, Proton, 010308 nuclear & particles physics, QC1-999, Cyclotron, Nuclear data, Experimental data, Alpha particle, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, 030218 nuclear medicine & medical imaging, law.invention, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, law, 0103 physical sciences
Abstract

International audience; The aim of this article is to give the status of nuclear data collected in the framework of the production of innovative radionuclides for therapy and diagnosis applications in collaboration with the GIP ARRONAX, which possesses a multi-particle high energy cyclotron, and to show constrains that can be put on nuclear codes. In order to assess the cross section of a given production route, experiments have been carried out using the stacked-foil technique and gamma-spectroscopy for a set of radionuclides of medical interest: photon (Tc-99m) and positon (Sc-44g) emitters for diagnosis, electron (Re-186g, Tb-155, Sn-117m) and alpha particle (Th-226, Ra-233, Bi-213) emitters for therapeutic applications. A systematic comparison has been performed between the results from the TALYS code (version 1.6) and the large set of data collected using different projectiles (proton, deuteron and alpha particle) from few MeV up to 70 MeV and covering a wide range of target masses. A better overall agreement with our experimental data has been obtained with a combination of models already included in the TALYS code differing from the default one.

Published
2017
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18. Thorium-232 fission induced by light charged particles up to 70 MeV

Author

Ferid Haddad, C. Duchemin, Nathalie Michel, Arnaud Guertin, Vincent Métivier, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Accélérateur pour la Recherche en Radiochimie et Oncologie [Nantes Atlantique] (GIP ARRONAX), Université de Nantes (UN)-Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER-UNICANCER-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011)

Subjects
Physics, Fission products, 010308 nuclear & particles physics, Fission, QC1-999, High intensity, Cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Mass spectrometry, 01 natural sciences, Charged particle, 030218 nuclear medicine & medical imaging, law.invention, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, law, 0103 physical sciences, Isotopes of thorium
Abstract

International audience; Studies have been devoted to the production of alpha emitters for medical application in collaboration with the GIP ARRONAX that possesses a high energy and high intensity multi-particle cyclotron. The productions of Ra-223, Ac-225 and U-230 have been investigated from the Th-232(p,x) and Th-232(d,x) reactions using the stacked-foils method and gamma spectrometry measurements. These reactions have led to the production of several fission products, including some with a medical interest like Mo-99, Cd-115g and I-131. This article presents cross section data of fission products obtained from these undedicated experiments. These data have been also compared with the TALYS code results.

Published
2017
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19. 232Th(d,4n)230Pa cross-section measurements at ARRONAX facility for the production of 230U

Author

Ferid Haddad, Nathalie Michel, Arnaud Guertin, C. Duchemin, Vincent Métivier, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Cyclotron ARRONAX, GIP, and Equipex Arronax-Plus (No ANR-11-EQPX-0004)

Subjects
Cancer Research, Proton, Cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010403 inorganic & nuclear chemistry, 01 natural sciences, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, law, Radiology, Nuclear Medicine and imaging, Orders of magnitude (speed), Irradiation, Radionuclide, Radiochemistry, Alpha-targeted therapy, Stacked-foil technique, Chemistry, Thick-target yield (TTY), Thorium, Nuclear data, Protactinium, 0104 chemical sciences, Semiconductor detector, TALYS code, Production cross section, Yield (chemistry), Uranium, Molecular Medicine, ARRONAX cyclotron
Abstract

Introduction 226 Th ( T 1/2 =31min) is a promising therapeutic radionuclide since results, published in 2009, showed that it induces leukemia cells death and activates apoptosis pathways with higher efficiencies than 213 Bi. 226 Th can be obtained via the 230 U α decay. This study focuses on the 230 U production using the 232 Th(d,4n) 230 Pa( β −) 230 U reaction. Methods Experimental cross sections for deuteron-induced reactions on 232 Th were measured from 30 down to 19MeV using the stacked-foil technique with beams provided by the ARRONAX cyclotron. After irradiation, all foils (targets as well as monitors) were measured using a high-purity germanium detector. Results Our new 230 Pa cross-section values, as well as those of 232 Pa and 233 Pa contaminants created during the irradiation, were compared with previous measurements and with results given by the TALYS code. Experimentally, same trends were observed with slight differences in orders of magnitude mainly due to the nuclear data change. Improvements are ongoing about the TALYS code to better reproduce the data for deuteron-induced reactions on 232 Th. Conclusions Using our cross-section data points from the 232 Th(d,4n) 230 Pa reaction, we have calculated the thick-target yield of 230 U, in Bq/μA·h. This value allows now to a full comparison between the different production routes, showing that the proton routes must be preferred.

Published
2014
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20. New excitation functions for proton induced reactions on natural titanium, nickel and copper up to 70 MeV

Author

C. Duchemin, Ferid Haddad, Arnaud Guertin, Vincent Métivier, Nathalie Michel, Eric Garrido, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
Nuclear reaction, Nuclear and High Energy Physics, Work (thermodynamics), Proton, chemistry.chemical_element, 010403 inorganic & nuclear chemistry, 7. Clean energy, 01 natural sciences, stacked-foil technique, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, nickel, 0302 clinical medicine, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], 70 MeV proton beam, titanium, Instrumentation, Range (particle radiation), Chemistry, TALYS 1.6, Copper, 0104 chemical sciences, Nickel, copper, ARRONAX cyclotron, Atomic physics, Excitation, Titanium
Abstract

New excitation functions for proton induced nuclear reactions on natural titanium, nickel and copper were measured, using the stacked-foil technique and gamma spectrometry, up to 70 MeV. The experimental cross sections were measured using the Ti-nat(p,x) V-48, Ni-nat(p,x) Ni-57 and Cu-nat(p,x) Zn-62,Co-56 monitor reactions recommended by the International Atomic Energy Agency (IAEA), depending on the investigated energy range. Data have been extracted for the Ti-nat(p,x) Sc-43,44m,46,47,48, V-48, K-42,43, Ni-nat(p,x) Ni-56,57, Co-55,56,57,58, Mn-52,54, Cu-nat(p,x) Cu-61,64, Ni-57, Co-56,57,58,60, Zn-62,65, Mn-54 reactions. Our results are discussed and compared to the existing ones as well as with the TALYS code version 1.6 calculations using default models. Our experimental data are in overall good agreement with the literature. TALYS is able to reproduce, in most cases, the experimental trend. Our new experimental results allow to expand our knowledge on these excitation functions, to confirm the existing trends and to give additional values on a large energy range. This work is in line with the new Coordinated Research Project (CRP) launched by the IAEA to expand the database of monitor reactions.

Published
2016
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21. Deuteron induced Tb-155 production, a theranostic isotope for SPECT imaging and auger therapy

Author

Vincent Métivier, C. Duchemin, Nathalie Michel, Arnaud Guertin, Ferid Haddad, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
Gadolinium, chemistry.chemical_element, Terbium, 010403 inorganic & nuclear chemistry, Radiation Dosage, 01 natural sciences, stacked-foil technique, Theranostic Nanomedicine, 030218 nuclear medicine & medical imaging, Auger therapy, 03 medical and health sciences, 0302 clinical medicine, gadolinium target, Spect imaging, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Excitation function, Radionuclide, Radiation, Isotope, Radiotherapy, Chemistry, Radionuclide Generators, Radiochemistry, TALYS 1.6, Terbium-155, Deuterium, 0104 chemical sciences, 3. Good health, Yield (chemistry), deuteron beam, Radiopharmaceuticals
Abstract

International audience; HIGHLIGHTS • The medical interest of terbium-155. • Deuteron induced reactions on natural gadolinium up to 34 MeV. • Excitation functions measured with the stacked-foil technique. • Comparison with the TALYS code version 1.6. • Tb-155 achievable yield and radionuclide purity. ABSTRACT Several terbium isotopes are suited for diagnosis or therapy in nuclear medicine. Tb-155 is of interest for SPECT imaging and/or Auger therapy. High radionuclide purity is mandatory for many applications in medicine. The quantification of the activity of the produced contaminants is therefore as important as that of the radionuclide of interest. The experiments performed at the ARRONAX cyclotron (Nantes, France), using the deuteron beam delivered up to 34 MeV, provide an additional measurement of the excitation function of the Gd-nat(d,x)Tb-155 reaction and of the produced terbium and gadolinium contaminants. In this study, we investigate the achievable yield for each radionuclide produced in natural gadolinium as a function of the deuteron energy. Other reactions are discussed in order to define the production route that could provide Tb-155 with a high yield and a high

Published
2016
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22. How to produce high specific activity tin-117m using alpha particle beam

Author

Ferid Haddad, C. Duchemin, Arnaud Guertin, Vincent Métivier, Nathalie Michel, M. Essayan, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
Excitation function, Cadmium, Radiation, Chemistry, Cyclotron, Radiochemistry, chemistry.chemical_element, Alpha particle, Electron, 010403 inorganic & nuclear chemistry, 01 natural sciences, 030218 nuclear medicine & medical imaging, 0104 chemical sciences, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Yield (chemistry), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Irradiation, Beam (structure)
Abstract

International audience; Tin-117m is an interesting radionuclide for both diagnosis and therapy, thanks to the gamma-ray and electron emissions, respectively, resulting from its decay to tin-117g. The high specific activity of tin-117 m is required in many medical applications, and it can be obtained using a high energy alpha particle beam and a cadmium target. The experiments performed at the ARRONAX cyclotron (Nantes, France) using an alpha particle beam delivered at 67.4 MeV provide a measurement of the excitation function of the Cd-nat(α,x)Sn-117 m reaction and the produced contaminants. The Cd-116(α,3n)Sn-117m production cross section has been deduced from these experimental results using natural cadmium. Both production yield and specific activity as a function of the projectile energy have been calculated. These informations help to optimize the irradiation conditions to produce tin-117 m with the required specific activity using α particles with a cadmium target.

Published
2016
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23. How to produce scandium-44 efficiently?

Author

Arnaud Guertin, Ferid Haddad, C. Duchemin, Vincent Métivier, Nathalie Michel, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
Materials science, Inorganic chemistry, chemistry.chemical_element, Hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, chemistry, Oncology, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Radiology, Nuclear Medicine and imaging, Scandium, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016
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24. Is there an interest to use deuteron beams to produce nonconventional radionuclides?

Author

Ferid Haddad, Mickaël Bourgeois, Cyrille Alliot, Vincent Métivier, Jacques Barbet, Arnaud Guertin, Nadia Audouin, C. Bourdeau, A.C. Bonraisin, Sandrine Huclier-Markai, C. Duchemin, V. Bossé, Aurélien Vidal, Nathalie Michel, M. Pageau, R. Kerdjoudj, J. Laizé, M. Mokili, Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Cyclotron ARRONAX [Saint-Herblain], ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Laboratoire SUBATECH Nantes (SUBATECH), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes)

Subjects
Physics, Radionuclide, Hematology, 030218 nuclear medicine & medical imaging, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, Deuterium, Oncology, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Radiology, Nuclear Medicine and imaging, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016
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25. Tb-155 production with gadolinium target: proton, deuteron or alpha beam?

Author

Arnaud Guertin, Ferid Haddad, C. Duchemin, Vincent Métivier, Nathalie Michel, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
Materials science, Proton, Gadolinium, Radiochemistry, chemistry.chemical_element, Alpha (ethology), Hematology, Oncology, chemistry, Deuterium, Radiology Nuclear Medicine and imaging, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Radiology, Nuclear Medicine and imaging, Beam (structure), ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016
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26. COASTAL HYDRODYNAMIC MODELING TO SUPPORT THE RECONSTRUCTION OF BREAKWATERS AT CAP-DES-ROSIERS

Author

Steve Renaud, Alain Drouin, Nicolas Guillemette, Benoit Ruest, Mathieu Roy, and Vincent Métivier

Subjects
geography, geography.geographical_feature_category, National park, Fishing, Storm, Oceanography, Peninsula, Breakwater, General Earth and Planetary Sciences, Coastal engineering, human activities, Geology, Channel (geography), General Environmental Science
Abstract

The fishing harbor of Cap-des-Rosiers is located at the northeast end of the Gaspé Peninsula and is owned by Parks Canada. It is located within the Forillon National Park, at the mouth of the Whalen River. Two jetties, composed of Berlin walls, delineate the inner channel of the harbor and act as breakwaters. Despite the presence of these breakwaters, significant problems of agitation have been observed in the past within the harbor during storms.

Published
2018
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27. 42 Deposited dose measurement using bremsstrahlung X-rays

Author

Nicolas Varmenot, Noël Servagent, Vincent Métivier, F. Haddad, F. Ralite, Charbel Koumeir, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), and UNICANCER

Subjects
0301 basic medicine, Physics, Particle therapy, Proton, medicine.medical_treatment, Cyclotron, Biophysics, Bremsstrahlung, General Physics and Astronomy, General Medicine, Alpha particle, 030218 nuclear medicine & medical imaging, Computational physics, law.invention, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, law, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], medicine, Radiology, Nuclear Medicine and imaging, Particle beam, Charged particle beam, ComputingMilieux_MISCELLANEOUS, Beam (structure)
Abstract

Introduction With the development of particle therapy, patient dose verification tools are needed to ensure the accuracy of treatment. Non-invasive methods to measure the deposited energy exist. These are based on the PET-imaging technique, taking advantage of the radionuclides created during the interaction of hadrons with the medium [1] . An alternative method is studied and presented in this work. The detection of bremsstrahlung X-rays (XR) emitted directly by medium [2] is a promising way to obtain all or part of the deposited energy in the medium. This study describes a method to determine the deposited dose by a charged particle beam, for different incident energies. The results obtained for protons and alpha particles of 70 MeV will be presented. Methods The experimental set-up allows the irradiations of a PMMA target by alpha particles or protons delivered by the cyclotron ARRONAX (energy [3] has been developed to model the emitted XR spectrum. Results The first experiment, with alpha particles of 68 MeV, shows a good agreement between theoretical and simulated XR spectrums. The number of bremsstrahlung XR detected for one gray received by the medium is 1060+/−140. Uncertainty includes detection efficiency, the beam charge and the statistical counting fluctuations, and uncertainties about measurement of the number of the incident particles. The simulated spectrum indicates a number of 970 XR/Gy. Thus the number of XR per gray demonstrates a good sensibility. These encouraging results led us to perform experiments using proton beams with different energies. The analyses are in progress and the results will also be presented. Conclusions This work presents an alternative, on-line, non-invasive method based on the measurement of bremsstrahlung XR emitted during the interaction of a particle beam with matter. Proof of concept was obtained for 68 MeV alpha particles. Proton beams with energies from 17 to 70 MeV are under study. The objective is to evaluate the sensitivity of the method, in order to use the bremsstrahlung to monitor the beam and/or the deposited dose at energies close to those used in protontherapy and hadrontherapy.

Published
2018
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28. Nuclear medical imaging using β+γ coincidences from 44Sc radio-nuclide with liquid xenon as detection medium

Author

A. Faivre, Cyril Grignon, Olivier Couturier, Noël Servagent, P. Le Ray, Jean-François Chatal, Manuel Bardiès, Thomas Carlier, Ludovic Ferrer, L. Luquin, E. Morteau, Tomiyoshi Haruyama, Vincent Métivier, S. Girault, Dominique Thers, Jean-Pierre Cussonneau, Jacques Barbet, S. Lupone, Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Recherches en cancérologie, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), and Etiennette Auffray, Paul Lecoq and Olivier Mundler

Subjects
Nuclear and High Energy Physics, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Point source, Astrophysics::High Energy Astrophysical Phenomena, Compton telescope, Physics::Medical Physics, Cyclotron, chemistry.chemical_element, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, 01 natural sciences, Particle detector, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Optics, Xenon, law, 0103 physical sciences, Nuclide, Instrumentation, Image resolution, Physics, Time projection chamber, 010308 nuclear & particles physics, business.industry, 29.40.Mc, 77.22.−d, 87.58.Fg, 95.55.Ka, chemistry, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Medical imaging, Liquid xenon, business, Scandium
Abstract

International audience; We report on a new nuclear medical imaging technique based on the measurement of the emitter location in the three dimensions with a few mm spatial resolution using β+γ emitters. Such measurement could be realized thanks to a new kind of radio-nuclides which emit a γ-ray quasi-simultaneously with the β+ decay. The most interesting radio-nuclide candidate, namely 44Sc, will be potentially produced at the Nantes cyclotron ARRONAX. The principle is to reconstruct the intersection of the classical line of response (obtained with a standard PET camera) with the direction cone defined by the third γ-ray. The emission angle measurement of this additional γ-ray involves the use of a Compton telescope for which a new generation of camera based on a liquid xenon (LXe) time projection chamber is considered. GEANT3 simulations of a large acceptance LXe Compton telescope combined with a commercial micro-PET (LSO crystals) have been performed and the obtained results will be presented. They demonstrate that a good image can be obtained from the accumulation of each three-dimensional measured position. A spatial resolution of 2.3 mm has been reached with an injected activity of 0.5 MBq for a 44Sc point source emitter.

Published
2007
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29. Production of Scandium-44m and Scandium-44g with Deuterons on Calcium-44: Cross Section measurements and Production Yield Calculations

Author

Ferid Haddad, C. Duchemin, Arnaud Guertin, Vincent Métivier, Nathalie Michel, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Cyclotron ARRONAX, GIP, Investissement d'Avenir, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011)

Subjects
Materials science, Proton, Cyclotron, chemistry.chemical_element, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010403 inorganic & nuclear chemistry, 01 natural sciences, stacked-foil technique, Calcium Carbonate, 030218 nuclear medicine & medical imaging, law.invention, Nuclear physics, 03 medical and health sciences, Cross section (physics), 0302 clinical medicine, law, Sc-44m/Sc-44g in-vivo generator, Sc-44m/Sc-44g in vivo generator, Production (economics), Radiology, Nuclear Medicine and imaging, Scandium, Ca-44 target, Radiochemistry, Radiological and Ultrasound Technology, TALYS 1.6, Pet imaging, Cyclotrons, Deuterium, 0104 chemical sciences, chemistry, excitation function, Positron-Emission Tomography, Yield (chemistry), deuteron beam, Radiopharmaceuticals
Abstract

HIGHLIGHTS • Production of Sc-44 m, Sc-44 g and contaminants. • Experimental values determined using the stacked-foil technique. • Thick-Target production Yield (TTY) calculations. • Comparison with the TALYS code version 1.6.Among the large number of radionuclides of medical interest, Sc-44 is promising for PET imaging. Either the ground-state Sc-44 g or the metastable-state Sc-44 m can be used for such applications, depending on the molecule used as vector. This study compares the production rates of both Sc-44 states, when protons or deuterons are used as projectiles on an enriched Calcium-44 target. This work presents the first set of data for the deuteron route. The results are compared with the TALYS code. The Thick-Target production Yields of Sc-44 m and Sc-44 g are calculated and compared with those for the proton route for three different scenarios: the production of Sc-44 g for conventional PET imaging, its production for the new 3 γ imaging technique developed at the SUBATECH laboratory and the production of a Sc-44 m/Sc-44 g in vivo generator for antibody labelling.

Published
2015
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30. Production of medical isotopes from a thorium target irradiated by light charged particles up to 70 MeV

Author

Arnaud Guertin, C. Duchemin, Ferid Haddad, Nathalie Michel, Vincent Métivier, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Cyclotron ARRONAX, GIP, Investissement d'Avenir, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
Nuclear reaction, Physics, Radioisotopes, Radiological and Ultrasound Technology, Isotope, Fission, Thorium, chemistry.chemical_element, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Charged particle, Nuclear physics, Deuterium, chemistry, Radionuclide therapy, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Radiology, Nuclear Medicine and imaging, Irradiation, Nuclear Medicine, ComputingMilieux_MISCELLANEOUS, Nuclear Fission
Abstract

International audience; The irradiation of a thorium target by light charged particles (protons and deuterons) leads to the production of several isotopes of medical interest. Direct nuclear reaction allows the production of Protactinium-230 which decays to Uranium-230 the mother nucleus of Thorium-226, a promising isotope for alpha radionuclide therapy. The fission of Thorium-232 produces fragments of interest like Molybdenum-99, Iodine-131 and Cadmium-115g. We focus our study on the production of these isotopes, performing new cross section measurements and calculating production yields. Our new sets of data are compared with the literature and the last version of the TALYS code.

Published
2015
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31. How to produce the highest tin-117m specific activity?

Author

Nathalie Michel, Arnaud Guertin, Vincent Métivier, Ferid Haddad, C. Duchemin, M. Essayan, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
Chemistry, chemistry.chemical_element, Hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Oncology, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Radiology, Nuclear Medicine and imaging, Specific activity, Tin, ComputingMilieux_MISCELLANEOUS, Nuclear chemistry
Abstract

International audience

Published
2016
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32. Cross section measurements of deuteron induced nuclear reactions on natural titanium up to 34 MeV

Author

Ferid Haddad, Arnaud Guertin, C. Duchemin, Vincent Métivier, Nathalie Michel, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Cyclotron ARRONAX, GIP, Investissement d'Avenir, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011)

Subjects
Nuclear reaction, Cyclotron, (nat)Ti(d, chemistry.chemical_element, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Radiation Dosage, 7. Clean energy, 030218 nuclear medicine & medical imaging, law.invention, Nuclear physics, 03 medical and health sciences, Cross section (physics), 0302 clinical medicine, law, Materials Testing, Scattering, Radiation, Computer Simulation, Scandium, Monitor reactions, Excitation function, Titanium, Radiation, Isotope, Chemistry, Stacked-foil technique, TALYS 1.6, Deuterium, Models, Chemical, 030220 oncology & carcinogenesis, Deuteron beam, Atomic physics, Excitation, x)
Abstract

International audience; Experimental cross sections for deuteron induced nuclear reactions on natural titanium were measured, using the stacked-foil technique and gamma spectrometry, up to 34MeV with beams provided by the ARRONAX cyclotron. The experimental cross section values were monitored using the (nat)Ti(d,x)(48)V reaction, recommended by the IAEA. The excitation functions for (nat)Ti(d,x)(44m,46,47,48)Sc are presented and compared with the existing ones and with the TALYS 1.6 code calculations using default models. Our experimental values are in good agreement with data found in the literature. TALYS 1.6 is not able to give a good estimation of the production cross sections investigated in this work. These production cross sections of scandium isotopes fit with the new Coordinated Research Project (CRP) launched by the International Atomic Energy Agency (IAEA) to expand the database of monitor reactions.

Published
2014
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33. Development of a PIXE method at high energy with the ARRONAX cyclotron

Author

J. Gaudillot, Ferid Haddad, Arnaud Guertin, D. Ragheb, Nathalie Michel, Charbel Koumeir, Noël Servagent, Vincent Métivier, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Cyclotron ARRONAX, GIP, and Equipex Arronax Plus no ANR-11-EQPX-0004, CPER 2007-2013, including funding from the Regional Council of Pays de la Loire, the ‘‘Conseil general de Loire-Atlantique’’, the French government and the FEDER (European Union)

Subjects
High energy, High energy particle, Materials science, Proton, Health, Toxicology and Mutagenesis, Ion beam analysis, Cyclotron, Analytical chemistry, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010403 inorganic & nuclear chemistry, 01 natural sciences, Spectral line, Analytical Chemistry, law.invention, law, 0103 physical sciences, Multilayer, Radiology, Nuclear Medicine and imaging, Spectroscopy, Range (particle radiation), 010308 nuclear & particles physics, Public Health, Environmental and Occupational Health, Pollution, 0104 chemical sciences, Nuclear Energy and Engineering, ARRONAX, High energy PIXE, Nondestructive analysis, Physics::Accelerator Physics, Beam (structure)
Abstract

International audience; The high energy PIXE (HEPIXE) method is a multi-elemental non-destructive ion beam analysis technique. It is based on the detection of the X-ray emitted due to the interaction of high energy particle beam with a sample. This technique is fast and allows the analysis of heavy and medium elements in thin (lm), thick (mm) and multilayer samples. At the ARRONAX facility (Nantes, France), the HEPIXE method has been used to determine the composition of natural and synthetic sodalites. Photochromic properties of these samples are supposed to come from the trace elements (concentration in the ppm range) present in the samples. Taking advantage of the 70 MeV proton beam available at our facility, the HEPIXE methodhas been also used to study multilayer samples. It has been shown that it is possible to determine the composition of each layer, their thicknesses and their depth position by analyzing the recorded X-ray spectra.

Published
2014
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34. EBT2 FILMS RESPONSE TO ALPHA RADIATION AT 48.3 MEV

Author

L. Schwob, C. Le Deroff, Arnaud Guertin, Charbel Koumeir, Nathalie Michel, Ferid Haddad, Freddy Poirier, Noël Servagent, Michel Chérel, Nicolas Varmenot, Vincent Métivier, Cyclotron ARRONAX, GIP, Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, and Equipex Arronax Plus no ANR-11-EQPX-0004, CPER 2007-2013, including funding from the Regional Council of Pays de la Loire, the 'Conseil general de Loire-Atlantique', the French government and the FEDER (European Union)

Subjects
Photon, Materials science, Film Dosimetry, Cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Radiation Dosage, Electromagnetic radiation, Spectral line, law.invention, law, Radiation, Ionizing, Radiology, Nuclear Medicine and imaging, Irradiation, Ions, Photons, Radiation, Radiological and Ultrasound Technology, Spectrometer, X-Rays, Public Health, Environmental and Occupational Health, Dose-Response Relationship, Radiation, General Medicine, Alpha particle, Equipment Design, Cyclotrons, Alpha Particles, Charged particle, Spectrophotometry, Facility Design and Construction, Calibration, Atomic physics, Algorithms
Abstract

International audience; To advance the development of a radiobiological experimental set-up for alpha particle irradiations at the Arronax cyclotron, experiments were performed to get the dose response of Gafchomic EBT2 films for alpha particles at 48.3 MeV. A system has been developed using a thin monitor copper foil and an X-ray spectrometer to measure the beam intensity and to calculate the delivered dose. On the other hand, the authors have irradiated EBT2 films, with 6-MV X rays, to get the dose response of EBT2 films for photons. The dose response curve for alpha particles shows an effect of polymerisation saturation compared with the dose response curve for photons.

Published
2014
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35. $^{232}$Th(d,xn)$^{230,232,233}$Pa Cross Section Measurements

Author

Arnaud Guertin, Vincent Métivier, C. Duchemin, Ferid Haddad, Nathalie Michel, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Cyclotron ARRONAX, and GIP

Subjects
Physics, Nuclear and High Energy Physics, 010405 organic chemistry, Cyclotron, Nuclear data, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010402 general chemistry, 7. Clean energy, 01 natural sciences, 0104 chemical sciences, law.invention, Nuclear physics, Cross section (physics), law, Atomic physics
Abstract

International audience; Cross sections for the (d,n), (d,2n) and (d,4n) reactions on 232Th were measured using the stackedfoil technique with beams provided by the ARRONAX cyclotron. These data are of relevance for the production of radionuclides. The measured cross sections were compared with previous measurements as well as with theoretical calculations using the code TALYS.

Published
2014
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36. Study of the resistive plate chambers for the ALICE Dimuon Arm

Author

B. Espagnon, F. Manso, M. Gallio, Chiara Oppedisano, E. Chiavassa, A. Baldit, O. Roig, V. Barret, Ermanno Vercellin, L. Lamoine, P. Crochet, N. De Marco, Enrico Scalas, A. Musso, Roberta Arnaldi, G. Blanchard, J. Fargeix, L. Royer, A Rahmani, L. Luquin, Enrico Scomparin, N. Bastid, Alessandro Ferretti, Vincent Métivier, Pietro Cortese, P. Dupieux, A. Piccotti, G. Dellacasa, P. Mereu, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), ALICE, and Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, Nuclear and High Energy Physics, Resistive touchscreen, 010308 nuclear & particles physics, 01 natural sciences, 030218 nuclear medicine & medical imaging, Nuclear physics, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, 0103 physical sciences, Electrode, Bakelite, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, ALICE (propellant), Instrumentation, Gamma irradiation
Abstract

Presentation made at RPC99 and submitted to Elsevier PreprintThe trigger system for the ALICE Dimuon Arm will be based on Resistive Plate Chambers. An RPC prototype, with electrodes made of low resistivity bakelite (rho ~ 3.109 Ωcm) has been tested both at the SPS and at the GIF. The results for operation in streamer mode are presented here.

Published
2000
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37. The trigger of the ALICE dimuon arm: Architecture and detectors

Author

Pietro Cortese, G. Dellacasa, F. Manso, A. Rahmani, O. Roig, Enrico Scalas, L. Lamoine, E. Vercellin, P. Dupieux, M. Gallio, L. Royer, E. Chiavassa, N. Bastid, V. Barret, Vincent Métivier, Roberta Arnaldi, G. Blanchard, P. Crochet, A. Musso, V. Ramillen, A. Piccotti, J. Fargeix, L. Luquin, B. Espagnon, N. De Marco, Enrico Scomparin, A. Baldit, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ALICE, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes)

Subjects
Physics, Nuclear and High Energy Physics, Resistive touchscreen, 010308 nuclear & particles physics, business.industry, Detector, Time resolution, 01 natural sciences, ARM architecture, chemistry.chemical_compound, Optics, chemistry, 0103 physical sciences, Electrode, Bakelite, Cluster size, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], ALICE (propellant), 010306 general physics, business
Abstract

The trigger system of the ALICE dimuon arm is based on Resistive Plate Chambers (RPC). Besides a short description of the trigger system, the test results of a RPC proto-type with electrodes made of low resistivity bakelite (⋍ 3 · 10 9 Ω·cm) are presented. Rate capability, time resolution and cluster size have been measured for the RPC operated both in streamer and in avalanche mode. Although the rate capability is obviously higher in avalanche mode (few kHz/cm 2 ), remarkable results have been achieved even in streamer mode (several hundreds of Hz/cm 2 ).

Published
1999
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38. Measurements of 186Re production cross section induced by deuterons on natW target at ARRONAX facility

Author

C. Duchemin, Vincent Métivier, Ferid Haddad, Nathalie Michel, Arnaud Guertin, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Cyclotron ARRONAX, GIP, and Equipex Arronax Plus no ANR-11-EQPX-0004

Subjects
Radioisotopes, Cancer Research, Radiochemistry, Rhenium-186, Proton, Chemistry, Projectile, Cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Deuterium, law.invention, Nuclear physics, Cross section (physics), Rhenium, Stack (abstract data type), ARRONAX, law, Yield (chemistry), Molecular Medicine, Radiology, Nuclear Medicine and imaging, Beam (structure)
Abstract

Introduction The ARRONAX cyclotron, acronym for “Accelerator for Research in Radiochemistry and Oncology at Nantes Atlantique” is a new facility installed in Nantes, France. A dedicated program has been launched on production of innovative radioisotopes for PET imaging and for β − and α targeted radiotherapy using protons or α particles. Since the accelerator is also able to deliver deuteron beams up to 35 MeV, we have reconsidered the possibility of using them to produce medical isotopes. Indeed, in some cases, the use of deuterons allows higher production yield than protons. Methods 186Re is a β − emitter which has chemical properties close to the widely used 99mTc and has been used in clinical trials for palliation of painful bone metastases resulting from prostate and breast cancer. 186Re production cross section has been measured between 9 and 23 MeV using the ARRONAX deuteron beam and the stacked-foil technique. A novelty in our work is the use of a monitor foil behind each natW target foil in order to record efficiently the deuteron incident flux and energies all over the stack relying on the International Atomic Energy Agency (IAEA) recommended cross section of the natTi(d,x)48V reaction. Since a good optimization process is supposed to find the best compromise between production yield and purity of the final product, isotope of interest and contaminants created during irradiation are measured using gamma spectrometry. Results Our new sets of data are presented and compared with the existing ones and with results given by the TALYS code calculations. The thick target yield (TTY) has been calculated after the fit of our experimental values and compared with the IAEA recommended ones. Conclusions Presented values are in good agreement with existing data. The deuteron production route is clearly the best choice with a TTY of 7.8 MB/μAh at 30 MeV compared to 2.4 MBq/μAh for proton as projectile at the same energy. The TALYS code gives satisfactory results for 183,186Re isotopes.

Published
2013
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39. Corrigendum: Production of scandium-44m and scandium-44g with deuterons on calcium-44: cross section measurements and production yield calculations (2015Phys. Med. Biol.606847–64)

Author

Nathalie Michel, Arnaud Guertin, Vincent Métivier, C. Duchemin, and Ferid Haddad

Subjects
Materials science, Radiological and Ultrasound Technology, Analytical chemistry, chemistry.chemical_element, Calcium, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Cross section (physics), 0302 clinical medicine, chemistry, Deuterium, 030220 oncology & carcinogenesis, Yield (chemistry), Radiology, Nuclear Medicine and imaging, Scandium
Published
2016
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40. Simulation of the Temperature Change Induced by a Laser Pulse on a CFRP Composite Using a Finite Element Code for Ultrasonic Non-Destructive Testing

Author

Elisabeth Lys, Vincent Métivier, Franck Bentouhami, Benjamin Campagne, and Hubert Voillaume

Subjects
Materials science, business.industry, Composite number, Pulse duration, Fibre-reinforced plastic, Laser, law.invention, Pulse (physics), Stress (mechanics), law, Nondestructive testing, Ultrasonic sensor, Composite material, business
Abstract

Laser-ultrasonic is an innovating technique developed in aeronautics for quick and contactless inspection of composite materials. For the Non Destructive Evaluation (NDE) of composites, a short and powerful laser pulse generates ultrasonic waves. A part of the incident laser beam is absorbed by the surface and induces an elevation of the temperature of the material. This temperature increase generates local stress and thermal warping that are responsible for the generation of ultrasonic waves. This chapter of contribution describes the case of the thermal interaction between a CO2 laser beam pulse and a carbon fibre reinforced plastic (CFRP) composite material. The laser beam is considered spatially and temporally Gaussian and the material is decomposed as two media. The first one is a 40 μm thick resin and the second is a 4 mm thick CFRP. By considering the laser beam as a volumic heat source with a 120 ns pulse duration, a 90 mJ energy and a 10 ms time range between two pulses, we have developed a finite element model using the Elmer code to simulate the transient heat equation and to evaluate the composite temperature increase. The results of the thermal analyses are applied to understand the influence of resin skin thickness and pulse rate on the ultrasound generation.

Published
2012
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41. 108: Beam monitoring and dosimetry tools for radiobiology experiments at the cyclotron ARRONAX

Author

Arnaud Guertin, Michel Chérel, Noël Servagent, Vincent Métivier, L. Schwob, Nathalie Michel, F. Poirier, Nicolas Varmenot, Ferid Haddad, and C. Koumeir

Subjects
Physics, medicine.medical_specialty, Radiobiology, Nuclear engineering, Cyclotron, Hematology, law.invention, Oncology, law, medicine, Dosimetry, Radiology, Nuclear Medicine and imaging, Medical physics, Beam (structure)
Published
2014
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43. Extrinsic fibre Fabry-Perot interferometer for vibration and displacement measurement: the benefit of polarization decomposition

Author

Christian Yves Boisrobert, Noël Servagent, Elisabeth Ouisse, Vincent Métivier, Laboratoire SUBATECH Nantes (SUBATECH), and Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
polarization, Optical fiber, Materials science, Laser diode, business.industry, Orthogonal polarization spectral imaging, displacement measurement, law.invention, Photodiode, Semiconductor laser theory, Interferometry, Optics, optical fibre interferometer, law, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], vibration, business, optical sensor, Beam splitter, Fabry–Pérot interferometer
Abstract

International audience; We have successfully developed a new design of an extrinsic fibre Fabry-Perot interferometer (EFPI) sensor dedicated to the characterization of vibration and displacement of a target. This device, based on a low finesse Fabry-Perot cavity formed by the end of a 'sensing' optical fibre and the target, gives information on the direction of the motion without the use of an additional reference arm. The incoming light, emitted by a 1310 nm laser diode, is decomposed according to two orthogonal polarization orientation inside the cavity. The two resulting interference signals are then carried back by the same optical fibre and sent to two photodiodes via a coupler and a polarizing beam splitter. With a relativelysimple signal processing, a precision of lambda/4 is achieved for the measurement of the displacement, for which the direction is also extracted. In addition, one can determine the velocity of the motion, that have been successfully compared with a reference sensor. The use of a polarization maintaining fibre as sensing arm, not mandatory formonitored laboratory set-up, allows the use of this sensor principle even with external perturbation (temperature changes, mechanical stress...).

Published
2004
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44. Parallel Ionization Multiplier (PIM): application of a new concept of gaseous structure to tracking detectors

Author

S. Lupone, P. Leray, M. Meynadier, Noël Servagent, D. Thers, L. Luquin, Vincent Métivier, Richard Dallier, Georges Charpak, J. Samarati, P. Coulon, E. Morteau, M. Leguay, P. Laloux, Laboratoire SUBATECH Nantes (SUBATECH), and Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, business.industry, Physics::Instrumentation and Detectors, Detector, Laser, 7. Clean energy, 01 natural sciences, Charged particle, Anode, law.invention, Nuclear physics, law, Ionization, 0103 physical sciences, Beta particle, Optoelectronics, Multiplier (economics), [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, business, Instrumentation, Image resolution
Abstract

A new amplifying structure has been developed for beta imaging detectors: the Parallel Ionization Multiplier (PIM). PIM is made of a thin sandwich of two metallic micromeshes separated by a new laser machined insulating spacer. This structure allows high gain (105) with a good efficiency and a two-dimensional spatial resolution below 50 small mu, Greekm without strong discharge limitation. The capabilities of the PIM are now investigated in order to be used by high-energy physics experiments. A prototype of a tracking detector for charged particles using the PIM structure will be described. Thanks to the very small avalanche extension, the use of a highly segmented anode is possible. This detector would support high rate running conditions of hadron experiment.

Published
2003
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45. MEASUREMENT OF 230Pa AND 186Re PRODUCTION CROSS SECTIONS INDUCED BY DEUTERONS AT ARRONAX FACILITY

Author

Arnaud Guertin, Nathalie Michel, C. Duchemin, Ferid Haddad, Vincent Métivier, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Cyclotron ARRONAX, GIP, Equipex Arronax-Plus noANR-11-EQPX-0004, and Marianne Hamm

Subjects
Isotope, Proton, targeted radionu- clide therapy, Chemistry, Cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], stacked-foil technique, targeted radionuclide therapy, 3. Good health, law.invention, Nuclear physics, Cross section (physics), Production cross section, Deuterium, law, ARRONAX cyclotron, Irradiation, Decay product, α particles, Talys code
Abstract

A dedicated program has been launched on production of innovative radionuclides for PET imaging and for β- and α targeted radiotherapy using proton or α particles at the ARRONAX cyclotron. Since the accelerator is also able to deliver deuteron beams up to 35 MeV, we have reconsidered the possibility of using them to produce medical isotopes. Two isotopes dedicated to targeted therapy have been considered: 226Th, a decay product of 230Pa, and 186Re. The production cross sections of 230Pa and 186Re, as well as those of the contaminants created during the irradiation, have been determined by the stacked-foil technique using deuteron beams. Experimental values have been quantified using a referenced cross section. The measured cross sections have been used to determine expected production yields and compared with the calculated values obtained using the Talys code with default parameters.

Published
2014
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46. A low-resistivity RPC for the ALICE dimuon arm

Author

L. Lamoine, B. Espagnon, Vincent Métivier, Roberta Arnaldi, G. Blanchard, A. Piccotti, N DeMarco, G. Dellacasa, Ermanno Vercellin, Pietro Cortese, L. Royer, P. Dupieux, E. Chiavassa, Enrico Scalas, N. Bastid, A Rahmani, L. Luquin, V. Barret, Alessandro Ferretti, F. Manso, O. Roig, Enrico Scomparin, J. Fargeix, Mauro Gallio, P. Crochet, A. Musso, A. Baldit, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), ALICE, and Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, Nuclear and High Energy Physics, Large Hadron Collider, 010308 nuclear & particles physics, Physics::Instrumentation and Detectors, Resistive plate chamber, Time resolution, 01 natural sciences, 7. Clean energy, Nuclear physics, chemistry.chemical_compound, chemistry, Electrical resistivity and conductivity, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], 0103 physical sciences, Electrode, Bakelite, Cluster size, ALICE (propellant), 010306 general physics, Instrumentation
Abstract

In view of ALICE, the dedicated heavy-ion experiment at LHC, a resistive plate chamber (RPC) with electrodes made of low-resistivity bakelite ( rho approximately=3.5*10/sup 9/ Omega cm) has been tested at the CERN SPS both in streamer and in avalanche mode. The chamber has shown a stable behaviour and excellent rate capability: its efficiency is better than 95% for local particle fluxes of about 1 and 10 kHz/cm/sup 2/ for operation in streamer and in avalanche mode, respectively. The cluster size and the time resolution have also been measured for both modes of operation. (22 refs).

Published
2000

47. The ALICE Dimuon Trigger: Overview and Electronics Prototypes

Author

B. Espagnon, A. Musso, Franck Manso, Ermanno Vercellin, L. Lamoine, Enrico Scalas, A. Baldit, Pascal Dupieux, Valerie Ramillien Barret, C. Drancourt, A. Piccotti, E. Chiavassa, Roberta Arnaldi, G. Dellacasa, P. Crochet, Alessandro Ferretti, N. De Marco, Enrico Scomparin, F. Lefèvre, O. Roig, G. Blanchard, J. Fargeix, L. Royer, L. Luquin, P. Rosnet, A. Genoux-Lubain, Nicole Bastid, Pietro Cortese, Vincent Métivier, M. Gallio, Chiara Oppedisano, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), ALICE, and Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear and High Energy Physics, Particle physics, Physics::Instrumentation and Detectors, STRIPS, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, law.invention, Digital pattern generator, law, 0103 physical sciences, Electronics, Detectors and Experimental Techniques, 010306 general physics, Nuclear Experiment, Instrumentation, Physics, Large Hadron Collider, Spectrometer, 010308 nuclear & particles physics, business.industry, Detector, Electrical engineering, Signature (logic), Quark–gluon plasma, High Energy Physics::Experiment, business
Abstract

Presentation made at RPC99 and submitted to NIM ALICE is the LHC experiment (2005) dedicated to the study of heavy ion collisions. Amongst the ALICE sub-detectors, the muon spectrometer will investigate the dimuon production from heavy resonance (J/psi, Gamma) decays, which is believed to be a promising signature of the QGP (Quark Gluon Plasma) formation.For maximum efficiency of the spectrometer, a dedicated dimuon trigger is presently built. The detector partis itself based on RPCs operated in streamer mode and is the topic of another contribution to this conference. This paper gives the principle and the simulated performances of the trigger and is also focussed on the description of the electronics prototypes and future developments. The RPCs are read-out by X and Y orthogonal strips: the front-end chips are presently developed. The signals are sent to the trigger electronics which basically performs a pt cut on the tracks to reduce the background. A prototype of fast (decision time 200 ns) programmable electronics working in a pipelined mode at 40 MHz has been built and tested. This prototype handles simultaneously 160 digital information from the strips. The tests of the trigger card have required the construction of a pattern generator (160 bits at 40 MHz).

Published
1999

48. Dynamical aspects of fragment production in heavy ion collisions

Author

Plagnol, E., Auger, G., Assenard, M., Bacri, C. O., Benlliure, J., Bisquer, E., Borderie, B., Bougault, R., Brou, R., J-L, Charvet, Chbihi, A., Colin, J., Cussol, D., Dayras, R., Demeyer, A., Defilippo, E., Dore, D., Durand, D., Philippe Eudes, Genoux-Lubain, A., Gerlic, E., Marie Germain, Gourio, D., Guinet, D., Laforest, R., Lautesse, P., Laville, J. L., Lebreton, L., Lebrun, C., Lecolley, J. F., Le Fevre, A., Lefort, T., Legrain, R., Lopez, O., Louvel, M., Nathalie Marie, Vincent Métivier, Nalpas, L., Pârlog, M., Peter, J., Politi, O., Pollacco, E. C., Rahmani, A., Régimbart, R., Reposeur, T., Rosato, E., M-F, Rivet, Saint-Laurent, F., Salou, S., Siwek, A., Squalli, M., Steckmeyer, J. C., Stern, M., Tamain, B., Tassan-Got, L., Tirel, O., Vient, E., Volant, C., Wieleczko, J. P., Wieloch, A., Yugang, M., E., Plagnol, G., Auger, M., Assenard, C. O., Bacri, J., Benlliure, E., Bisquer, B., Borderie, R., Bougault, R., Brou, J. L., Charvet, A., Chbihi, J., Colin, D., Cussol, R., Dayra, E., DE FILIPPO, A., Demeyer, D., Dor, D., Durand, P., Eude, A., GENOUX LUBAIN, E., Gerlic, M., Germain, D., Gourio, D., Guinet, R., Laforest, P., Lautesse, J. L., Laville, L., Lebreton, C., LE BRUN, C., Lebrun, J. F., Lecolley, A., LE FVRES, T., Lefort, R., Legrain, O., Lopez, M., Louvel, L., Nalpa, N., Marie, V., Mtivier, M., Parlog, J., Pter, G., Politi, E., Pollacco, A., Rahmani, R., Regimbart, T., Rposeur, M. F., Rivet, Rosato, Elio, F., SAINT LAURENT, S., Salou, A., Siwek, M., Squalli, J. C., Steckmeyer, M., Stern, B., Tamain, L., TASSAN GOT, O., Tirel, E., Vient, C., Volant, J. P., Wielezcko, A. WIELOCH E. M., Yu, Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Frois B. Goutte D. Guillemaud-Mueller D., Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Robert, Suzanne

Subjects
[PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]
Published
1999

49. Study of resistive plate chambers for the ALICE dimuon spectrometer

Author

P. Dupieux, A. Piccotti, G. Dellacasa, Roberta Arnaldi, G. Blanchard, C. Soave, A. Musso, V. Ramillen, A. Rahmani, Mauro Gallio, Ermanno Vercellin, Enrico Scomparin, A. Baldit, O. Roig, L. Luquin, J. Fargeix, Vincent Métivier, L. Royer, Pietro Cortese, E. Chiavassa, F. Manso, B. Espagnon, N. De Marco, N. Bastid, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), ALICE, and Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics, Nuclear and High Energy Physics, Resistive touchscreen, Spectrometer, 010308 nuclear & particles physics, business.industry, Detector, Time resolution, 01 natural sciences, Atomic and Molecular Physics, and Optics, Nuclear physics, chemistry.chemical_compound, Optics, chemistry, Electrical resistivity and conductivity, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], 0103 physical sciences, Bakelite, ALICE (propellant), Detectors and Experimental Techniques, 010306 general physics, business, Beam (structure)
Abstract

The trigger system of the ALICE dimuon spectrometer is based on RPC detectors. We present experimental results of a beam test about rate capability, time resolution and cluster size of single gap RPC detectors operating both in `streamer mode' and in `avalanche mode'. We have compared the performances of small chambers (50*50 cm/sup 2/) built with bakelite of different resistivity, from ~3.10/sup 9/ Omega cm to ~3.10/sup 11/ Omega cm. For the low resistivity RPC we obtained a rate capability of several hundreds of Hz/cm/sup 2/ when it is operating in `streamer mode', and of several thousands of Hz/cm/sup 2 / when it is operating in `avalanche mode'. (7 refs).

Published
1999

50. Reaction mechanisms and multi-fragment emission around the Fermi energy

Author

Tamain, B., Vincent Métivier, Colin, J., Cussol, D., Lefort, T., Lukasik, J., Plagnol, E., Auger, G., Bacri, C. O., Bellaize, N., Bocage, F., Borderie, B., Bougault, R., Brou, R., Buchet, P., J-L, Charvet, Chbihi, A., Dayras, R., Demeyer, A., Dore, D., Durand, D., Galichet, E., Genouin-Duhamel, E., Gerlic, E., Guinet, D., Lautesse, P., Laville, J. L., Lecolley, J. F., Legrain, R., Nicolas Le Neindre, Lopez, O., Louvel, M., M Maskay, A., Nalpas, L., Nguyen, A. D., Pârlog, M., Peter, J., M-F, Rivet, Rosato, E., Saint-Laurent, F., Steckmeyer, J. C., Tabacaru, G., Tassan-Got, L., Tirel, O., Vient, E., Vintache, D., Volant, C., Wieleczko, J. P., Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Grand Accélérateur National d'Ions Lourds (GANIL), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Feldmeier H. Noerenberg W. Knoll J. Wambach J., INDRA, Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]
Published
1999

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