550 results on '"Vinceneux, P."'
Search Results
2. Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study
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Lochmann, Mathilde, Girodet, Magali, Despax, Johanna, Baudry, Valentine, Duranti, Julie, Mastroianni, Bénédicte, Vanacker, Hélène, Vinceneux, Armelle, Brahmi, Mehdi, Renard, Olivier, Verlingue, Loïc, Amini-Adle, Mona, Swalduz, Aurélie, Gautier, Julien, Ducimetière, Françoise, Anota, Amélie, Cassier, Philippe A., Chvetzoff, Gisèle, and Christophe, Véronique
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- 2024
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3. A multicentric, single arm, open-label, phase I/II study evaluating PSMA targeted radionuclide therapy in adult patients with metastatic clear cell renal cancer (PRadR)
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David Kryza, Armelle Vinceneux, Anne-Sophie Bidaux, Gwenaelle Garin, Delphine Tatu, Claire Cropet, Jean-Noël Badel, David Perol, and Anne-Laure Giraudet
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177Lu-PSMA-1 ,Radiolabelled therapy ,mccRCC ,PFS ,Renal cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Despite advancements in managing metastatic clear cell renal carcinoma (mccRCC) through antiangiogenic tyrosine kinase inhibitors and immunotherapy, there remains a demand for novel treatments for patients experiencing progression despite the use of these medications. There is currently no established standard treatment for patients receiving third therapy line. Prostate Specific Membrane Antigen (PSMA) whose high expression has been demonstrated in metastatic aggressive prostate adenocarcinoma is also highly expressed in neovessels of various solid tumors including renal cell carcinoma (RCC): 86% of clear cell RCC, 61% of chromophobe RCC, and 28% of papillary RCC. Therefore, PSMA may be a target expressed in metastatic ccRCC for radionuclide therapy using PSMA ligands radiolabeled with Lutetium-177 (PRLT). 177Lu-PSMA delivers ß-particle radiation to PSMA-expressing cells and the surrounding microenvironment with demonstrated efficacy in metastatic prostate cancer. Methods This is a multicenter phase I/II study designed to assess the tolerability and effectiveness of 177Lu-PSMA-1 in individuals with PSMA-positive metastatic clear cell renal cell carcinoma (ccRCC), identified through 68Ga-PSMA PET, conducted in France (PRadR). 48 patients will be treated with 4 cycles of 7.4 GBq of 177Lu-PSMA-1 every 6 weeks. The primary objective is to evaluate the safety of 177Lu-PSMA-1 (phase I) and the efficacy of 177Lu-PSMA-1 in mccRCC patients (phase II). Primary endpoints are incidence of Severe Toxicities (ST) occurring during the first cycle (i.e. 6 first weeks) and disease Control Rate after 24 weeks of treatment (DCR24w) as per RECIST V1.1. Secondary objective is to further document the clinical activity of 177Lu-PSMA-1 in mccRCC patients (duration of response (DoR), best overall response rate (BORR), progression fee survival (PFS) and overall survival (OS). Discussion Our prospective study may lead to new potential indications for the use of 177Lu-PSMA-1 in mccRCC patients and should confirm the efficacy and safety of this radionuclide therapy with limited adverse events. The use of 177Lu-PSMA-1may lead to increase disease control, objective response rate and the quality of life in mccRCC patients. Trial registration ClinicalTrials.gov: NCT06059014.
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- 2024
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4. Added value of whole‐exome and RNA sequencing in advanced and refractory cancer patients with no molecular‐based treatment recommendation based on a 90‐gene panel
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Armelle Dufresne, Valéry Attignon, Anthony Ferrari, Laurie Tonon, Sandrine Boyault, Séverine Tabone‐Eglinger, Philippe Cassier, Olivier Trédan, Nadège Corradini, Armelle Vinceneux, Aurélie Swalduz, Alain Viari, Sylvie Chabaud, David Pérol, Jean Yves Blay, and Pierre Saintigny
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cancer biology ,cancer management ,gene panel ,molecular tumor board ,precision oncology ,RNA‐sequencing ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Introduction The objective was to determine the added value of comprehensive molecular profile by whole‐exome and RNA sequencing (WES/RNA‐Seq) in advanced and refractory cancer patients who had no molecular‐based treatment recommendation (MBTR) based on a more limited targeted gene panel (TGP) plus array‐based comparative genomic hybridization (aCGH). Materials and Methods In this retrospective analysis, we selected 50 patients previously included in the PROFILER trial (NCT01774409) for which no MBT could be recommended based on a targeted 90‐gene panel and aCGH. For each patient, the frozen tumor sample mirroring the FFPE sample used for TGP/aCGH analysis were processed for WES and RNA‐Seq. Data from TGP/aCGH were reanalyzed, and together with WES/RNA‐Seq, findings were simultaneously discussed at a new molecular tumor board (MTB). Results After exclusion of variants of unknown significance, a total of 167 somatic molecular alterations were identified in 50 patients (median: 3 [1–10]). Out of these 167 relevant molecular alterations, 51 (31%) were common to both TGP/aCGH and WES/RNA‐Seq, 19 (11%) were identified by the TGP/aCGH only and 97 (58%) were identified by WES/RNA‐Seq only, including two fusion transcripts in two patients. A MBTR was provided in 4/50 (8%) patients using the information from TGP/aCGH versus 9/50 (18%) patients using WES/RNA‐Seq findings. Three patients had similar recommendations based on TGP/aCGH and WES/RNA‐Seq. Conclusions In advanced and refractory cancer patients in whom no MBTR was recommended from TGP/aCGH, WES/RNA‐Seq allowed to identify more alterations which may in turn, in a limited fraction of patients, lead to new MBTR.
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- 2024
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5. Rationale for Prostate-Specific-Membrane-Antigen-Targeted Radionuclide Theranostic Applied to Metastatic Clear Cell Renal Carcinoma
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Anne Laure Giraudet, Armelle Vinceneux, Valentin Pretet, Emilie Paquet, Alicia Sanchez Lajusticia, Fouzi Khayi, Jean Noël Badel, Helen Boyle, Aude Flechon, and David Kryza
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radionuclide therapy ,metastatic clear cell renal carcinoma ,PSMA ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Prostate-specific membrane antigen (PSMA), whose high expression has been demonstrated in metastatic aggressive prostate adenocarcinoma, is also highly expressed in the neovessels of various solid tumors, including clear cell renal cell carcinoma (ccRCC). In the VISION phase III clinical trial, PSMA-targeted radioligand therapy (PRLT) with lutetium 177 demonstrated a 4-month overall survival OS benefit compared to the best standard of care in heavily pretreated metastatic prostate cancer. Despite the improvement in the management of metastatic clear cell renal cell carcinoma (mccRCC) with antiangiogenic tyrosine kinase inhibitor (TKI) and immunotherapy, there is still a need for new treatments for patients who progress despite these drugs. In this study, we discuss the rationale of PRLT applied to the treavtment of mccRCC.
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- 2023
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6. Reasons for acceptance and refusal of early palliative care in patients included in early-phase clinical trials in a regional comprehensive cancer centre in France: protocol for a qualitative study
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Françoise Ducimetière, Amélie Anota, Helene Vanacker, Philippe Cassier, Mehdi Brahmi, Véronique Christophe, Gisele Chvetzoff, Magali Girodet, Johanna Despax, Valentine Baudry, Julie Duranti, Bénédicte Mastroianni, Armelle Vinceneux, Olivier Renard, Julien Gautier, and Manon Britel
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Medicine - Abstract
Introduction A few studies have highlighted the potential synergy between early palliative care and inclusion in an early-phase clinical trial that may improve quality of life, reduce symptoms of exhaustion related to the side effects of treatment and allow patients to complete their treatment protocol. The primary objective of this qualitative study is to evaluate the reasons for acceptance or refusal of early palliative care in patients included in early-phase clinical trials.Method and analysis All patients from the Centre Léon Bérard (Comprehensive Cancer Centre in Lyon, France) who consent to one of the early-phase clinical trials proposed at the centre will be invited to participate in this study. The cohort will consist of a subgroup (n=20) of patients who accept palliative care together with their clinical trial, and a second subgroup (n=20) of patients who decline it. Patients will be interviewed in exploratory interviews conducted by a psychology researcher before the start of their clinical trial. The interviews will be audio-recorded. Patients will also be asked to complete quality of life and anxiety/depression questionnaires both before the beginning of the treatment and at the end of their clinical trial. The content of the interviews will be analysed thematically. Descriptive and comparative statistical analysis of both cohorts will also be conducted.Ethics and dissemination Personal data will be collected and processed in accordance with the laws and regulations in force. All patients will give informed consent to participate. This study complies with reference methodology MR004 of the Commission Nationale de l'Informatique et des Libertés. The protocol has received the validation of an ethics committee (Groupe de Réflexion Ethique du CLB, number: 2020-006). The results will be disseminated through conference presentations and peer-reviewed publications.Trial registration number NCT04717440.
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- 2022
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7. Gastrointestinal metastases in renal cell carcinoma: A retrospective multicenter GETUG (Groupe d'Etude des Tumeurs Uro-Genitales) study.
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Carneiro, Florian, Vinceneux, Armelle, Larroquette, Mathieu, Rony, Maelle, Carril, Lucia, Laguerre, Brigitte, Blazevic, Ilfad, Barthelemy, Philippe, Teyssonneau, Diego, Goujon, Morgan, Linassier, Claude, Thiery-Vuillemin, Antoine, Roubaud, Guilhem, Mourey, Loic, Albiges, Laurence, Gravis, Gwenaelle, Gross-Goupil, Marine, and Cancel, Mathilde
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- 2024
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8. Correction to: Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study
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Bruneel, Fabrice, Tubach, Florence, Mira, Jean-Paul, Houze, Sandrine, Gibot, Sebastien, Huisse, Marie-Genevieve, Megarbane, Bruno, Choquet, Christophe, Corne, Philippe, Peytel, Eric, Villers, Daniel, Camus, Christophe, Bouchaud, Olivier, Caumes, Eric, Girard, Pierre-Marie, Simon, Fabrice, Kalloumeh, Antoine, Roy, Carine, Durand, Remy, Le Bras, Jacques, Matheron, Sophie, Wolff, Michel, Mourvillier, B., Aubron, C., Bouadma, L., Regnier, B., d’Ortenzio, E., Matra, R., Bouvet, E., Tourret, J., Dorchies, J., Males, S., Rioux, C., Flicoteaux, R., Yeni, P., Spingler, F., Kargougou, E., Casalino, E., Ollivier, V., Grandchamp, B., Miri, Y., Fresnoy, E., Grelon, F., Asfar, P., Kouatchet, A., Mercat, A., Joly-Guillou, M. L., Kempf, M., Eveillard, M., Daoudal, P., Royer, A., Runge, I., Mathonnet, A., Boulain, T., Bret, L., Hocqueloux, L., Segalin, J. M., Mille, C., Niang, M., Prazuck, T., Fortin, M., Schortgen, F., Brun Buisson, C., Botterel, F., Bretagne, S., Leroy, O., Georges, H., Meybeck, A., Guery, B., Patoz, P., Dhennain, C., Chakarian, D., Azougagh, K., Bonmarchand, G., Abboud, P., Favennec, L., Lemeland, J. F., Petrognani, R., Nau, A., Puidupin, A., Carpentier, J. P., Garnotel, E., Moalic, J. L., Tual, L., Amathieu, R., Dhonneur, G., N’Diaye, M., Jeantils, V., Chassaignon, C., Guillerm, A. L., Riche, D., Javaud, N., Pevirieri, F., Benkel, J., Luis, D., Bon, M. C., Lenoir, G., Bernot, B., Collignon, A., Bemba, D., Poilane, I., Trouillet, J. L., Luyt, C. E., Mirabel, M., Chastre, J., Hochedez, P., Perignon, A., Thellier, M., Danis, M., Faussart, A., Nafziger, J., Gastinne, H., Pichon, N., Ajzenberg, D., Darde, M. L., Jacobs, F., Brivet, F., Veyradier, A., Marfaing-Koka, A., Timsit, J. F., Hammer, L., Maubon, D., Pelloux, H., Pene, F., Charpentier, J., Marque, S., Rousseau, C., Guezennec, P., Troche, G., Bedos, J. P., Eloy, O., Palette, C., Therby, A., Monnier, S., Greder-Bellan, A., Cougot, P., Kuteifan, K., Mootien, Y., Guiot, P., Delarbre, J. M., Kiefer, M. H., Page, B., Vieillard Baron, A., Dunand, J., Loubieres, Y., Ricome, J. L., Peltier, J. Y., Giudicelli, Y., Pelletier, C., Rousseau, J. M., Imbert, P., Rapp, C., Mechai, F., Barruet, R., Debord, T., Pilo, J. E., Cavallo, J. D., Angles, O., Genestal, M., Bretonnière, C., Nicolet, L., Jalin, L., Talarmin, J. P., Grossi, O., Raffi, F., Gay-Andrieu, F., Bompoil, T., Gros, A., Le Tulzo, Y., Revest, M., Fily, F., Chapplain, J. M., Tattevin, P., Michelet, C., Chevrier, S., Guigen, C., Baud, F., Launay, J. M., Gourmel, C., Derouin, F., de Miranda, S., Thiery, G., Legriel, S., Azoulay, E., Schlemmer, B., Colin de Verdieres, N., Lagrange-Xelot, M., Gallien, S., De Castro, N., Pavie, J., Lafaurie, M., Molina, J. M., Sarfati, C., Derouin, F., Jonquet, P., Schved, J. F., Biron, C., Bret, C., Klouche, K., Beraud, P., Cristol, J. P., Gruson, D., Herpe, B., Delacre, M., Castaing, Y., Fialon, P., Vincendeau, P., Vincent, F., Karoubi, P., Cohen, Y., Cordel, H., Prendki, V., Cailhol, J., Abgrall, S., Gros, H., Fantinato, C., Cymbalista, F., Senghor, Y., Memain, N., Thuong, M., Adrie, C., Darques, L., Moret, G., Fraisse, F., Godineau, N., Chaplain, C., Prevel, M., Mary, R. J., Plantefeve, G., Bleichner, G., Mentec, H., Leturdu, F., Hyvernat, H., Bernardin, G., Delaunay, P., Marty, P., Baudel, J. L., Maury, E., Offenstadt, G., Meynard, J. L., Pacanowski, J., Ouazene, Z., Bollens, D., Meyohas, M. C., Fonquerine, L., Belkadi, G., Magne, D., Roux, P., Rusel, L., Ricard, J. D., Dreyfuss, D., Mortier, E., Vinceneux, P., Bloch, M., Galeazzi, G., Charbonneau, P., Duhamel, C., Leclercq, R., Delassus, J. L., Malbec, D., Lusina, D., Broutier, H., Charlier, C., Lanternier, F., Coignard, H., Lortholary, O., Bougnoux, M. E., Consigny, P. H., Simons de Fanti, A., Leguern, A. S., Massin, F., and The PALUREA Study Group
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- 2017
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9. Current Systemic Treatment Options for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis: Targeting the CSF1/CSF1R Axis
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Brahmi, Mehdi, Vinceneux, Armelle, and Cassier, Philippe A.
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- 2016
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10. Congrès Targeted Anticancer Therapies — TAT 2015
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Ajgal, Z., Bellesoeur, A., Baylot, C., Bigenwald, C., Brunot, A., Carton, E., De Guillebon, E., De Nonneville, A., Martin-Babau, J., Flippot, R., Gougis, P., Mahjoubi, L., Marques, N., Larrouquère, L., Pons, E., Verlingue, L., Viala, M., Vicier, C., Vinceneux, A., Vozy, A., Lavaud, P., and Ferté, C.
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- 2015
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11. Tenofovir DF/emtricitabine and efavirenz combination therapy for HIV infection in patients treated for tuberculosis: the ANRS 129 BKVIR trial
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Lortholary, Olivier, Roussillon, Caroline, Boucherie, Céline, Padoin, Christophe, Chaix, Marie-Laure, Breton, Guillaume, Rami, Agathe, Veziris, Nicolas, Patey, Olivier, Caumes, Eric, May, Thierry, Molina, Jean-Michel, Robert, Jérome, Tod, Michel, Fagard, Catherine, Chêne, Geneviève, Aumaître, H., Borsato, F., Malet, M., Médus, M., Moreau, L., Neuville, S., Saada, M., Abgrall, S., Ahoudji, D., Balmard, L., Bentata, M., Bouchaud, O., Boudribila, A., Cailhol, J., Dhote, R., Djebbar, R., Gros, H., Honoré, P., Huynh, T., Krivitzky, A., Mansouri, R., Pizzocolo, C., Rouges, F., Viot, E., Amar, B., Bantsimba, J., Dellion, S., Patey, O., Richier, L., Dupon, M., Dutronc, H., Neau, D., Ragnaud, J. M., Raymond, I., Boucly, S., Gailhoustet, L., Lortholary, O., Maignan, A., Touam, F., Viard, J. P., Bergmann, J. F., Boulanger, E., Delcey, V., Diemer, M., Durel, A., Jouade, F., Parrinello, M., Rami, A., Sellier, P., Brazille, P., Leclerc, C., Welker, Y., Bernard, L., Berthé, H., Perronne, C., Salomon, J., de Truchis, P., Bolliot, C., Couzigou, C., Derradji, O., Escaut, L., Teicher, E., Vittecoq, D., Chakvetadze, C., Fontaine, C., LʼYavanc, T., Maresca, A., Pialoux, G., Slama, L., Tuna, L., Bornarel, D., Boué, F., Chassaing, A., Chaiba-Berroukeche, L., Chambrin, V., Delavalle, A. M., Galanaud, P., Levy, A., Pignon, C., Bonnet, D., Ecobichon, J. L., Fournier, I., Fraquiero, G., Gerbe, J., Gervais, A., Guiyedi, V., Iordache, L., Joly, V., Klutse, P., Laurichesse, J. J., Leport, C., Onanga, M., Pahlaval, G., Phung, B. C., Ralaimazava, P., Yeni, P., Almasi, F., Basler, M., Benammar, N., Brunes, A., Guérin, C., Guillevin, L., Meddour, R., Salmon, D., Spiridon, G., Tahi, T., Bloch, M., Ferreira, C., Mahe, I., Manceron, V., Minozzi, C., Mortier, E., Simonpoli, A. M., Vinceneux, P., Zeng Ai, F., Chesnel, C., Dominguez, S., Jouve, P., Lascaux-Cametz, A. S., Lelièvre, J. D., Levy, Y., Melica, G., Sobel, A., Bentaleb, N., Blondin-Diop, A., Bonmarchand, M., Bossi, P., Brancon, C., Breton, G., Bricaire, F., Caby, F., Canestri, A., Clavel, C., Edeb, N., Herson, S., Iguertsira, M., Katlama, C., Kouadio, H., Lagarde, P., Lopez, J. L., Marguet, F., Martinez, V., Remidi, H., Simon, A., Souchon, J. F., Valantin, M. A., Bollens, D., Girard, P. M., Lagneau, J. L., Lefebvre, B., Mouchotte, R., Ouazene, Z., Sebire, M., Theveny-Christiany, A., Valin, N., Bourgarit, A., de Castro, N., Delgado, J., Ferret, S., Lascoux-Combe, C., Molina, J. M., Parlier, S., Pavie, J., Pintado, C., Ponscarme, D., Rachline, A., Sereni, D., Taulera, O., de Verdiere, C., Vincent, F., Bernard, N., Bonarek, M., Bonnet, F., Delaune, J., Lacoste, D., Louis, I., Malvy, D., Mercier, P., Morlat, P., Pertusa, M. C., Schottey, M., Chanteloube, N., Eden, A., Le Moing, V., Makilson, A., de Boever, C. Merle, Reynes, J., Turrière, C., Tramoni, C., Vidal, M., Anavena, C., Billaud, E., Biron, C., Bonnet, B., Bouchez, J., Boutoille, D., Brosseau, D., Brunct, C., Colas, M., Feuillebois, N., Hüe, H., Launay, E., le Houssine, P. Morineau, Raffi, F., Reliquet, V., Cua, E., Dellamonica, P., Durant, J., Rahelinirina, V., Arvieux, C., Chapplain, J. M., Fily, F., Labbay, E., Michelet, C., Morin, F., Peaucelle, C., Revest, M., Ratajczak, M., Souala, F., Tattevin, P., Thomas, R., Alvarez, M., Balsarin, F., Bonnet, E., Busato, F., Cuzin, L., Marche, D., Marchou, B., Massip, P., Obadia, M., Porte, L., Aissi, E., Ajana, F., Alcaraz, I., Baclet, V., Dubus, S., Gérard, Y., Guerroumi, H., Huleux, T., Lahouste, A., Marien, M. C., Melliez, H., Mouton, Y., Pennel, M. P., Valette, M., Viget, N., Yazdanpanah, Y., Bevilacqua, S., Boyer, L., Lecompte, T., Letranchant, L., May, T., Rabaud, C., Thomas, L., Vancon, R., Wassoumbou, S., Abboud, P., Borsa-Lebas, F., Caron, F., Debab, Y., Etienne, M., Faucon, M., Gueit, I., Brouqui, P., Mokhtari, S., Moreau, J., Schlojsers, M., Vandergheynst, E., Chousterman, M., Delacroix-Szmania, I., El Harrar, B., Garrait, V., Joannes, S., Luquet-Besson, I., Mouchet, M., Richier, L., Stevens, A. Blase, Dupont, C., Maresca, A. Freire, Greffe, S., Hanslik, T., Landi, B., Leporrier, J., Rouveix, E., Toth, K., El Mansouf, L., Khuong-Josses, M. A., Méchali, D., Le Besnerais, J. Phalip, Taverne, B., Barclay, F., Fain, O., Flexor, G., Stirnemann, J., Tassi, S., Levast, M., Rogeaux, O., Raffenot, D., Tous, J., Lortholary, O., Bouchaud, O., Chaix, M. L., Chêne, G., Couffin-Cadiergues, S., Dupon, M., Fagard, C., Joly, V., Launay, O., Molina, J. M., Robert, J., Roussillon, C., Rouzioux, C., Tod, M., Yazdanpanah, Y., Lortholary, O., Breton, G., Caumes, E., May, T., Roussillon, C., Veziris, N., Badets, M., Boucherie, C., Fagard, C., Chêne, G., Roussillon, C., Terras, N., Guérin, C., Altare, F., Bourgarit, A., Carcelain, G., Trylesinski, A., Aubron-Olivier, C., Nguyen, T., and Bennai, Y.
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- 2016
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12. Policondritis atrofiante
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Pouchot, J., Vinceneux, P., and Piette, J.-C.
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- 2009
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13. Use of freeze-dried bone allografts in revision total hip arthroplasty
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Caltran, Maurice, Savornin, Claude, Le Couteur, Patrick, Jouan, Paul, Deroche, Philippe, Vinceneux, Jean-François, and Barnouin, Laurence
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- 2002
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14. La maladie périodique au sein des maladies auto-inflammatoires
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Vinceneux, P. and Pouchot, J.
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- 2005
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15. Maladie périodique, symptomatologie clinique et biologique
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Vinceneux, P. and Pouchot, J.
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- 2005
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16. De la maladie périodique à l’amylose
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Vinceneux, P. and Pouchot, J.
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- 2005
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17. Effectiveness of written guidelines on the appropriateness of thromboprophylaxis prescriptions for medical patients: a prospective randomized study
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FONTAINE, A., MAHÉ, I., BERGMANN, J. F., FIESSINGER, J. N., DHOTE, R., COHEN, P., and VINCENEUX, P.
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- 2006
18. Rheumatoid arthritis and schizophrenia: a negative association at a dimensional level
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Gorwood, P., Pouchot, J., Vinceneux, P., Puéchal, X., Flipo, R.M., De Bandt, M., and Adès, J.
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- 2004
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19. Localisations extraméningées des infections à méningocoque : à propos de 14 cas
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Guignard, S, Manceron, V, Pouchot, J, Mortier, E, and Vinceneux, P
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- 2004
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20. Typical and atypical Coganʼs syndrome: 32 cases and review of the literature
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Grasland, A., Pouchot, J., Hachulla, E., Blétry, O., Papo, T., and Vinceneux, P.
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- 2004
21. Authors’ reply to Rozin and Quinn et al
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Pouchot, J, Rudler, M, Gentelle, S, Grasland, A, Vinceneux, P, and Paycha, F
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- 2003
22. Low dose methotrexate osteopathy in a patient with polyarticular juvenile idiopathic arthritis
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Rudler, M, Pouchot, J, Paycha, F, Gentelle, S, Grasland, A, and Vinceneux, P
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- 2003
23. Onset of rheumatoid arthritis following curative treatment of a somatostatinoma
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Grasland, A., Pouchot, J., Vinceneux, P., and Ruszniewski, P.
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- 2002
24. Anticorps bispécifiques ciblant CD3 en oncologie solide et onco-hématologie
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Vanacker, Hélène, Vinceneux, Armelle, Nicolas-Virelizier, Emmanuelle, Brahmi, Mehdi, and Cassier, Philippe A.
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Les thérapies bispécifiques ciblant CD3, appartiennent aux nouvelles immunothérapies anti-tumorales stimulant les lymphocytes T contre un antigène d’intérêt : on parle de T-cell engager(TCE). Les TCE sont des anticorps ciblant la sous-unité epsilon du CD3 (CD3e) et un antigène tumoral, permettant une activation des lymphocytes T mais indépendante du CMH. Actuellement, le seul médicament ayant une autorisation de mise sur le marché est le blinatumomab qui cible CD3exCD19 dans les hémopathies lymphoïdes. D’autres TCE ciblant notamment CD20 ou BSMA sont en développement avancé dans les lymphomes et le myélome, avec des résultats prometteurs. Ces succès ont relancé le développement de TCE dans les tumeurs solides, avec des résultats pour l’instant mitigés (notamment par la tolérance), mais qui ouvrent la porte à l’immunothérapie dans des tumeurs considérées comme réfractaires aux inhibiteurs des points de contrôle immunitaire tels les cancers de prostate ou les cancers colorectaux.
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- 2021
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25. Adult Still's disease associated with acute human parvovirus B19 infection
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Ouakil, H., Debin, M.L., and Vinceneux, P.
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- 1993
26. Actualités dans le traitement à la rechute des patients atteints de tumeurs germinales
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Carbonnaux, Mélodie, Vinceneux, Armelle, Peyrat, Patrice, and Fléchon, Aude
- Abstract
Les tumeurs germinales séminomateuses (TGS) et non séminomateuses (TGNS) sont rares mais leur incidence est en augmentation. Nous détaillerons les stratégies thérapeutiques en situation de rechute : en cas de tumeur germinale de stade I, le pronostic est excellent puisque le taux de guérison est de 98–99 %. Le risque évolutif est de 20 % en cas de TGS de stade I ou TGNS en l’absence d’emboles vasculaires et de 50 % en cas d’emboles. Le traitement repose sur le groupe pronostic de la classification internationale de consensus pour les TGS et les TGNS à faible risque naïves de chimiothérapie. Après un traitement adjuvant des TGNS, le protocole sera adapté au nombre de cycle réalisé en adjuvant et au groupe pronostic à la rechute. Cinq à 50 % des patients rechutent après une première ligne de chimiothérapie métastatique selon leur groupe pronostic initial. En cas de TGNS de mauvais pronostic avec mauvaise décroissance des marqueurs, la chimiothérapie dose-dense (protocole GETUG13) permet de diminuer le risque de rechute par rapport au traitement standard de 4 BEP. Le pronostic des tumeurs réfractaires ou en rechute après une première ligne est plus péjoratif, seule la moitié d’entre eux sera guérie par un traitement de rattrapage par chimiothérapie standard. La chimiothérapie intensive avec support de cellules souches hématopoïétiques est en cours d’évaluation en situation de premier rattrapage (étude TIGER). La prise en charge en centre expert et l’accès à l’innovation thérapeutique sont des éléments clés à une meilleure stratégie de soins pour ces patients au pronostic péjoratif.
- Published
- 2020
- Full Text
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27. État des lieux de la chimiothérapie intensive avec support de cellules-souches hématopoïétiques dans le traitement des tumeurs germinales
- Author
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Vinceneux, Armelle, Carbonnaux, Mélodie, and Fléchon, Aude
- Abstract
Le taux de guérison des patients atteints d’une tumeur germinale métastatique tout pronostic confondu est de 80 %. Vingt à 30 % d’entre eux vont présenter une rechute après une première ligne de chimiothérapie ou sont réfractaires d’emblée aux sels de platine. Les formes de mauvais pronostic selon la classification internationale de consensus (IGCCCG) ont un moins bon pronostic avec une survie de l’ordre de 50 à 60 %. La plupart des rechutes proviennent de ce groupe de malades. Le bénéfice de la chimiothérapie intensive dans les formes de mauvais pronostic n’a pas été démontré en première ligne par rapport à la chimiothérapie standard. De nombreux essais ont évalué différents régimes de chimiothérapie pour les patients en rechute, et notamment la réalisation de chimiothérapie intensive (High-Dose Chemotherapy[HDCT]) avec recueil et réinjection de cellules souches hématopoïétiques périphériques (CSHP). La place de l’HDCT en traitement de rattrapage en deuxième et en troisième ligne a fait l’objet de nombreuses publications, et reste à démontrer. L’HDCT est une option thérapeutique importante, probablement chez des patients bien sélectionnés dès la première rechute et la communauté internationale attend les résultats de l’essai prospectif TIGER.
- Published
- 2020
- Full Text
- View/download PDF
28. Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries
- Author
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Lodi, Sara, Del Amo, Julia, Moreno, Santiago, Bucher, H. C., Furrer, Hansjakob, Logan, Roger, Sterne, Jonathan, Pérez-Hoyos, Santiago, Jarrín, Inma, Phillips, Andrew, Olson, Ashley, Van Sighem, Ard, Reiss, Peter, Sabin, C., Jose, Sophie, Justice, Amy, Goulet, Joseph, Miró, José M., Ferrer, Elena, Meyer, Laurence, Seng, Rémonie, Vourli, Georgia, Antoniadou, Anastasia, Dabis, Francois, Vandenhede, Mari Anne, Costagliola, Dominique, Abgrall, S., Hernán, Miguel A., Hernan, Miguel, Bansi, L., Hill, T., Dunn, D., Porter, K., Glabay, A., Orkin, C., Thomas, R., Jones, K., Fisher, M., Perry, N., Pullin, A., Churchill, D., Gazzard, B., Nelson, M., Asboe, D., Bulbeck, S., Mandalia, S., Clarke, J., Delpech, V., Anderson, J., Munshi, S., Post, F., Easterbrook, P., Khan, Y., Patel, P., Karim, F., Duffell, S., Gilson, R., Man, S. L., Williams, I., Gompels, M., Dooley, D., Schwenk, A., Ainsworth, J., Johnson, M., Youle, M., Lampe, F., Smith, C., Grabowska, H., Chaloner, C., Ismajani Puradiredja, D., Phillips, A., Walsh, J., Weber, J., Kemble, C., Mackie, N., Winston, A., Leen, C., Wilson, A., Bezemer, D. O., Gras, L. A.J., Kesselring, A. M., Van Sighem, A. I., Zaheri, S., Van Twillert, G., Kortmann, W., Branger, J., Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., Van Der Meer, J. T.M., Wit, F. W.M.N., Godfried, M. H., Reiss, P., Van Der Poll, T., Nellen, F. J.B., Lange, J. M.A., Geerlings, S. E., Van Vugt, M., Pajkrt, D., Bos, J. C., Van Der Valk, M., Grijsen, M. L., Wiersinga, W. J., Brinkman, K., Blok, W. L., Frissen, P. H.J., Schouten, W. E.M., Van Den Berk, G. E.L., Veenstra, J., Lettinga, K. D., Mulder, J. W., Vrouenraets, S. M.E., Lauw, F. N., Van Eeden, A., Verhagen, D. W.M., Van Agtmael, M. A., Perenboom, R. M., Claessen, F. A.P., Bomers, M., Peters, E. J.G., Richter, C., Van Der Berg, J. P., Gisolf, E. H., Schippers, E. F., Van Nieuwkoop, C., Van Elzakker, E. P., Leyten, E. M.S., Gelinck, L. B.S., Pronk, M. J.H., Bravenboer, B., Kootstra, G. J., Delsing, C. E., Sprenger, H. G., Doedens, R., Scholvinck, E. H., Van Assen, S., Bierman, W. F.W., Soetekouw, R., Ten Kate, R. W., Van Vonderen, M. G.A., Van Houte, D. P.F., Kroon, F. P., Van Dissel, J. T., Arend, S. M., De Boer, M. G.J., Jolink, H., Ter Vollaard, H. J.M., Bauer, M. P., Weijer, S., El Moussaoui, R., Lowe, S., Schreij, G., Oude Lashof, A., Posthouwer, D., Koopmans, P. P., Keuter, M., Van Der Ven, A. J.A.M., Ter Hofstede, H. J.M., Dofferhoff, A. S.M., Warris, A., Van Crevel, R., Van Der Ende, M. E., De Vries-Sluijs, T. E.M.S., Schurink, C. A.M., Nouwen, J. L., Nispen Tot Pannerden, M. H., Verbon, A., Rijnders, B. J.A., Van Gorp, E. C.M., Hassing, R. J., Smeulders, A. W.M., Hartwig, N. G., Driessen, G. J.A., Den Hollander, J. G., Pogany, K., Juttmann, J. R., Van Kasteren, M. E.E., Hoepelman, A. I.M., Mudrikova, T., Schneider, M. M.E., Jaspers, C. A.J.J., Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Wassenberg, M. W.M., Barth, R. E., Geelen, S. P.M., Wolfs, T. F.W., Bont, L. J., Van Den Berge, M., Stegeman, A., Groeneveld, P. H.P., Alleman, M. A., Bouwhuis, J. W., Barin, F., Burty, C., Duvivier, C., Enel, P., Fredouille-Heripret, L., Gasnault, J., Khuong, M. A., Mahamat, A., Pilorgé, F., Tattevin, P., Salomon, Valérie, Jacquemet, N., Costagliola, D., Grabar, S., Guiguet, M., Lanoy, E., Lièvre, L., Mary-Krause, M., Selinger-Leneman, H., Lacombe, J. M., Potard, V., Bricaire, F., Herson, S., Katlama, C., Simon, A., Desplanque, N., Girard, P. M., Meynard, J. L., Meyohas, M. C., Picard, O., Cadranel, J., Mayaud, C., Pialoux, G., Clauvel, J. P., Decazes, J. M., Gérard, L., Molina, J. M., Diemer, M., Sellier, P., Bentata, M., Honoré, P., Jeantils, V., Tassi, S., Mechali, D., Taverne, B., Bouvet, E., Crickx, B., Ecobichon, J. L., Matheron, S., Picard-Dahan, C., Yeni, P., Berthé, H., Dupont, C., Chandemerle, C., Mortier, E., De Truchis, P., Tisne-Dessus, D., Weiss, L., Salmon, D., Auperin, I., Gilquin, J., Roudière, L., Viard, J. P., Boue, F., Fior, R., Delfraissy, J. F., Goujard, C., Jung, C., Lesprit, Ph, Vittecoq, D., Fraisse, P., Lang, J. M., Rey, D., Beck-Wirth, G., Stahl, J. P., Lecercq, P., Gourdon, F., Laurichesse, H., Fresard, A., Lucht, F., Bazin, C., Verdon, R., Chavanet, P., Arvieux, C., Michelet, C., Choutet, P., Goudeau, A., Maître, M. F., Hoen, B., Eglinger, P., Faller, J. P., Borsa-Lebas, F., Caron, F., Reynes, J., Daures, J. P., May, T., Rabaud, C., Berger, J. L., Rémy, G., Arlet-Suau, E., Cuzin, L., Massip, P., Thiercelin Legrand, M. F., Pontonnier, G., Viget, N., Yasdanpanah, Y., Dellamonica, P., Pradier, C., Pugliese, P., Aleksandrowicz, K., Quinsat, D., Ravaux, I., Tissot-Dupont, H., Delmont, J. P., Moreau, J., Gastaut, J. A., Poizot Martin, I., Retornaz, F., Soubeyrand, J., Galinier, A., Ruiz, J. M., Allegre, T., Blanc, P. A., Bonnet-Montchardon, D., Lepeu, G., Granet-Brunello, P., Esterni, J. P., Pelissier, L., Cohen-Valensi, R., Nezri, M., Chadapaud, S., Laffeuillade, A., Billaud, E., Raffi, F., Boibieux, A., Peyramond, D., Livrozet, J. M., Touraine, J. L., Cotte, L., Trepo, C., Strobel, M., Bissuel, F., Pradinaud, R., Sobesky, M., Cabié, A., Gaud, C., Contant, M., Aubert, V., Barth, J., Battegay, M., Bernasconi, E., Böni, J., Burton-Jeangros, C., Calmy, A., Cavassini, M., Egger, M., Elzi, L., Fehr, J., Fellay, J., Furrer, H., Haerry, D., Fux, C. A., Gorgievski, M., Günthard, H., Hasse, B., Hirsch, H. H., Hösli, I., Kahlert, C., Kaiser, L., Keiser, O., Klimkait, T., Kovari, H., Ledergerber, B., Martinetti, G., Martinez De Tejada, B., Metzner, K., Müller, N., Nadal, D., Pantaleo, G., Rauch, A., Regenass, S., Rickenbach, M., Rudin, C., Schmid, P., Schultze, D., Schöni-Affolter, F., Schüpbach, J., Speck, R., Taffé, P., Tarr, P., Telenti, A., Trkola, A., Vernazza, P., Weber, R., Yerly, S., Casabona, J., Gallois, A., Esteve, A., Podzamczer, D., Murillas, J., Gatell, J. M., Manzardo, C., Tural, C., Clotet, B., Ferrer, E., Riera, M., Segura, F., Navarro, G., Force, L., Vilaró, J., Masabeu, A., García, I., Guadarrama, M., Cifuentes, C., Dalmau, D., Jaen, Agustí, C., Montoliu, A., Pérez, I., Gargoulas, Freyra, Blanco, J. L., Garcia-Alcaide, F., Martínez, E., Mallolas, J., López-Dieguez, M., García-Goez, J. F., Sirera, G., Romeu, J., Jou, A., Negredo, E., Miranda, C., Capitan, M. C., Saumoy, M., Imaz, A., Tiraboschi, J. M., Murillo, O., Bolao, F., Peña, C., Cabellos, C., Masó, M., Vila, A., Sala, M., Cervantes, M., Jose Amengual, Ma, Navarro, M., Penelo, E., Barrufet, P., Bejarano, G., Molina, J., Alvaro, M., Mercadal, J., Fernandez, Juanse, Ospina, Jesus E., Muñoz, M. A., Caro-Murillo, A. M., Sobrino, P., Jarrín, I., Gomez Sirvent, J. L., Rodríguez, P., Aleman, M. R., Alonso, M. M., Lopez, A. M., Hernandez, M. I., Soriano, V., Labarga, P., Barreiro, P., Medrano, J., Rivas, P., Herrero, D., Blanco, F., Vispo, M. E., Martín, L., Ramírez, G., De Diego, M., Rubio, R., Pulido, F., Moreno, V., Cepeda, C., Hervás, Rl, Iribarren, J. A., Arrizabalaga, J., Aramburu, M. J., Camino, X., Rodrí-guez-Arrondo, F., Von Wichmann, M. A., Pascual, L., Goenaga, M. A., Gutierrez, F., Masia, M., Ramos, J. M., Padilla, S., Sanchez-Hellín, V., Bernal, E., Escolano, C., Montolio, F., Peral, Y., Berenguer, J., Lopez, J. C., Miralles, P., Cosín, J., Sanchez, M., Gutierrez, I., Ramírez, M., Padilla, B., Vidal, F., Sanjuan, M., Peraire, J., Veloso, S., Vilades, C., Lopez-Dupla, M., Olona, M., Vargas, M., Aldeguer, J. L., Blanes, M., Lacruz, J., Salavert, M., Montero, M., Cuéllar, S., De Los Santos, I., Sanz, J., Oteo, J. A., Blanco, J. R., Ibarra, V., Metola, L., Sanz, M., Pérez-Martínez, L., Sola, J., Uriz, J., Castiello, J., Reparaz, J., Arriaza, M. J., Irigoyen, C., Moreno, S., Antela, A., Casado, J. L., Dronda, F., Moreno, A., Pérez, M. J., López, D., Gutiérrez, C., Hernández, B., Pumares, M., Martí, P., García, L., Page, C., García, F., Hernández, J., Peña, A., Muñoz, L., Parra, J., Viciana, P., Leal, M., López-Cortés, L. F., Trastoy, M., Mata, R., Justice, A. C., Fiellin, D. A., Rimland, D., Jones-Taylor, C., Oursler, K. A., Titanji, R., Brown, S., Garrison, S., Rodriguez-Barradas, M., Masozera, N., Goetz, M., Leaf, D., Simberkoff, M., Blumenthal, D., Leung, J., Butt, A., Hoffman, E., Gibert, C., Peck, R., Mattocks, K., Braithwaite, S., Brandt, C., Bryant, K., Cook, R., Conigliaro, J., Crothers, K., Chang, J., Crystal, S., Day, N., Erdos, J., Freiberg, M., Kozal, M., Gandhi, N., Gaziano, M., Gerschenson, M., Good, B., Gordon, A., Goulet, J. L., Hernán, M. A., Kraemer, K., Lim, J., Maisto, S., Miller, P., Mole, L., O'Connor, P., Papas, R., Robins, J. M., Rinaldo, C., Roberts, M., Samet, J., Tierney, B., Whittle, J., Babiker, A., Brettle, R., Darbyshire, J., Goldberg, D., Hawkins, D., Jaffe, H., Johnson, A., McLean, K., Pillay, D., Cursley, Adam, Ewings, Fiona, Fairbrother, Keith, Louisa Gnatiuc, S. L., Murphy, Brendan, Douglas, G., Kennedy, N., Pritchard, J., Andrady, U., Rajda, N., Maw, R., McKernan, S., Drake, S., Gilleran, G., White, D., Ross, J., Toomer, S., Hewart, R., Wilding, H., Woodward, R., Dean, G., Heald, L., Horner, P., Glover, S., Bansaal, D., Eduards, S., Carne, C., Browing, M., Das, R., Stanley, B., Estreich, S., Magdy, A., O'Mahony, C., Fraser, P., Hayman, B., Jebakumar, S. P.R., Joshi, U., Ralph, S., Wade, A., Mette, R., Lalik, J., Summerfield, H., El-Dalil, A., France, J. A., White, C., Robertson, R., Gordon, S., McMillan, S., Morris, S., Lean, C., Vithayathil, K., McLean, L., Winter, A., Gale, D., Jacobs, S., Tayal, S., Short, L., Green, S., Williams, G., Sivakumar, K., Bhattacharyya, N. D., Monteiro, E., Minton, J., Dhar, J., Nye, F., De Souza, C. B., Isaksen, A., McDonald, L., Franca, A., William, L., Jendrulek, I., Peters, B., Shaunak, S., El-Gadi, S., Easterbrook, P. J., Mazhude, C., Johnstone, R., Fakoya, A., McHale, J., Waters, A., Kegg, S., Mitchell, S., Byrne, P., Rice, P., Fidler, S., Mullaney, S. A., McCormack, S., David, D., Melville, R., Phillip, K., Balachandran, T., Mabey-Puttock, S., Sukthankar, A., Murphy, C., Wilkins, E., Ahmad, S., Haynes, J., Evans, E., Ong, E., Grey, R., Meaden, J., Bignell, C., Loay, D., Peacock, K., Girgis, M. R., Morgan, B., Palfreeman, A., Wilcox, J., Tobin, J., Tucker, L., Saeed, A. M., Chen, F., Deheragada, A., Williams, O., Lacey, H., Herman, S., Kinghorn, D., Devendra, V. S., Wither, J., Dawson, S., Rowen, D., Harvey, J., Bridgwood, A., Singh, G., Chauhan, M., Kellock, D., Young, S., Dannino, S., Kathir, Y., Rooney, G., Currie, J., FitzGerald, M., Devendra, S., Keane, F., Booth, G., Green, T., Arumainayyagam, J., Chandramani, S., Rajamanoharan, S., Robinson, T., Curless, E., Gokhale, R., Tariq, A., Luzzi, G., Fairley, I., Wallis, F., Smit, E., Ward, F., Loze, B., Morlat, P., Bonarek, M., Bonnet, F., Nouts, C., Louis, I., Reliquet, V., Sauser, F., Biron, C., Mounoury, O., Hue, H., Brosseau, D., Ghosn, J., Rannou, M. T., Bergmann, J. F., Badsi, E., Rami, A., Parrinello, M., Samanon-Bollens, D., Campa, P., Tourneur, M., Desplanques, N., Jeanblanc, F., Chiarello, P., Makhloufi, D., Blanc, A. P., Allègre, T., Baillat, V., Lemoing, V., Merle De Boever, C., Tramoni, C., Sobesky, G., Abel, S., Beaujolais, V., Slama, L., Chakvetadze, C., Berrebi, V., Fournier, I., Gerbe, J., Koffi, K., Augustin-Normand, C., Miailhes, P., Thoirain, V., Brochier, C., Souala, F., Ratajczak, M., Beytoux, J., Jacomet, C., Rouveix, E., Morelon, S., Olivier, C., Lortholary, O., Dupont, B., Maignan, A., Ragnaud, J. M., Raymond, I., Leport, C., Jadand, C., Jestin, C., Longuet, P., Boucherit, S., Sereni, D., Lascoux, C., Prevoteau, F., Sobel, A., Levy, Y., Lelievre, J. D., Lascaux, A. S., Dominguez, S., Dumont, C., Aumâitre, H., Delmas, B., Saada, M., Medus, M., Guillevin, L., Tahi, T., Yazdanpanah, Y., Pavel, S., Marien, M. C., Drenou, B., Beck, C., Benomar, M., Tubiana, R., Ait Mohand, H., Chermak, A., Ben Abdallah, S., Touam, F., Drobacheff, C., Folzer, A., Obadia, M., Prudhomme, L., Bonnet, E., Balzarin, F., Pichard, E., Chennebault, J. M., Fialaire, P., Loison, J., Galanaud, P., Boué, F., Bornarel, D., Six, M., Ferret, P., Batisse, D., Gonzales-Canali, G., Devidas, A., Chevojon, P., Turpault, I., Lafeuillade, A., Cheret, A., Philip, G., Morel, P., Timsit, J., Amirat, N., Brancion, C., Cabane, J., Tredup, J., Stein, A., Ravault, I., Chavanet, C., Buisson, M., Treuvetot, S., Nau, P., Bastides, F., Boyer, L., Wassoumbou, S., Oksenhendeler, E., Bernard, L., Domart, Y., Merrien, D., Greder Belan, A., Gayraud, M., Bodard, L., Meudec, A., Beuscart, C., Daniel, C., Pape, E., Vinceneux, P., Simonpoli, A. M., Zeng, A., Fournier, L., Fuzibet, J. G., Sohn, C., Rosenthal, E., Quaranta, M., Chaillou, S., Sabah, M., Audhuy, B., Schieber, A., Moreau, P., Niault, M., Vaillant, O., Huchon, G., Compagnucci, A., De Lacroix Szmania, I., Richier, L., Lamaury, I., Saint-Dizier, F., Garipuy, D., Drogoul, M. P., Fabre, G., Lambert De Cursay, G., Abraham, B., Perino, C., Lagarde, P., David, F., Roche-Sicot, J., Saraux, J. L., Leprêtre, A., Fampin, B., Uludag, A., Morin, A. S., Bletry, O., Zucman, D., Regnier, A., Girard, J. J., Quinsat, D. T., Heripret, L., Grihon, F., Houlbert, D., Ruel, M., Chemlal, K., Debab, Y., Tremollieres, F., Perronne, V., Slama, B., Perré, P., Miodovski, C., Guermonprez, G., Dulioust, A., Boudon, P., Malbec, D., Patey, O., Semaille, C., Deville, J., Remy, G., Béguinot, I., Chambrin, V., Pignon, C., Estocq, G. A., Levy, A., Duracinsky, M., Le Bras, P., Ngussan, M. S., Peretti, D., Medintzeff, N., Lambert, T., Segeral, O., Lezeau, P., Laurian, Y., Piketty, C., Karmochkine, M., Eliaszewitch, M., Jayle, D., Kazatchkine, M., Colasante, U., Duval, X., Nouaouia, W., Vilde, J. L., Bollens, D., Binet, D., Diallo, B., Fonquernie, L., Lagneau, J. L., Launay, O., Pietrie, M. P., Sicard, D., Stieltjes, N., Michot, J., Bourdillon, F., Obenga, G., Escaut, L., Bolliot, C., Schneider, L., Iguertsira, M., Tomei, C., Dhiver, C., Tissot Dupont, H., Vallon, A., Gallais, J., Gallais, H., Durant, J., Mondain, V., Perbost, I., Cassuto, J. P., Karsenti, J. M., Venti, H., Ceppi, C., Krivitsky, J. A., Bouchaud, O., Honore, P., Delgado, J., Rouzioux, C., Burgard, M., Boufassa, L., Peynet, J., Pérez-Hoyos, S., Del Amo, J., Alvarez, D., Monge, S., Muga, R., Sanvisens, A., Tor, J., Rivas, I., Vallecillo, G., Del Romero, J., Raposo, P., Rodríguez, C., Vera, M., Hurtado, I., Belda, J., Fernandez, E., Alastrue, I., Santos, C., Tasa, T., Juan, A., Trullen, J., Garcia De Olalla, P., Cayla, J., Masdeu, E., Knobel, H., Mirò, J. M., Sambeat, M. A., Guerrero, R., Rivera, E., Marco, A., Quintana, M., Gonzalez, C., Castilla, J., Guevara, M., De Mendoza, C., Zahonero, N., Ortíz, M., Paraskevis, D., Touloumi, G., Pantazis, N., Bakoyannis, G., Gioukari, V., Antoniadou, A., Papadopoulos, A., Petrikkos, G., Daikos, G., Psichogiou, M., Gargalianos-Kakolyris, P., Xylomenos, G., Katsarou, O., Kouramba, A., Ioannidou, P., Kordossis, T., Kontos, A., Lazanas, M., Chini, M., Tsogas, N., Panos, G., Paparizos, V., Leuow, K., Kourkounti, S., Sambatakou, H., Mariolis, I., Skoutelis, A., Papastamopoulos, V., Baraboutis, I., Internal medicine, APH - Aging & Later Life, Pediatric surgery, CCA - Innovative therapy, ICaR - Circulation and metabolism, ICaR - Ischemia and repair, Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, Landsteiner Laboratory, AII - Amsterdam institute for Infection and Immunity, Infectious diseases, Global Health, Center of Experimental and Molecular Medicine, APH - Amsterdam Public Health, AII - Inflammatory diseases, and ARD - Amsterdam Reproduction and Development
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Opportunistic infection ,AIDS-Related Opportunistic Infections ,Immunology ,Population ,Retinitis ,HIV Infections ,Article ,17 Psychology And Cognitive Sciences ,Young Adult ,Immune reconstitution inflammatory syndrome ,Antiretroviral Therapy, Highly Active ,Neoplasms ,Virology ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,education ,Inverse probability weighting ,Aged ,education.field_of_study ,business.industry ,Developed Countries ,Incidence ,Progressive multifocal leukoencephalopathy ,Hazard ratio ,HIV ,virus diseases ,11 Medical And Health Sciences ,Middle Aged ,06 Biological Sciences ,medicine.disease ,United States ,Europe ,Infectious Diseases ,Anti-Retroviral Agents ,Unmasking ,Female ,Cytomegalovirus retinitis ,business - Abstract
Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.
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- 2014
29. Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries
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virus diseases - Abstract
Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis. Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting. Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis. Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
- Published
- 2014
30. Un point d'interrogation dans la tête !
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Grasland, A., Pouchot, J., Paycha, F., and Vinceneux, P.
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- 2000
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31. EDEN (Etude Désescalade sEmiNome): Prospective therapeutic de-escalation and miRNA-M371 biomarker evaluation phase II study for stage IIa/IIb < 3 cm seminomas.
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Vinceneux, Armelle, Pasquier, David, Blanc, Ellen, Attignon, Valéry, Blanchard, Pierre, and Flechon, Aude
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- 2023
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32. Hélène Vinceneux, Une analyse historicisée de l’évolution du rapport salarial : division du travail et configurations productives
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Hélène Vinceneux
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Social Sciences - Full Text
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33. Disorders of the sacro-iliac joint in children.
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Pouchot, J and Vinceneux, P
- Published
- 1989
34. Interêt des TEP dans le diagnostic du glucagonome
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Affo, C., primary, Cherif, D., additional, Vignali, J.-P., additional, Paycha, F., additional, Ruszniewski, P., additional, Montravess, F., additional, Vinceneux, P., additional, and Mahe, I., additional
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- 2009
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35. Polychondrite atrophiante
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Pouchot, J., primary, Vinceneux, P., additional, and Piette, J.-C., additional
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- 2009
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36. Fièvre boutonneuse méditerranéenne : diagnostic difficile devant une thrombopénie fébrile
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Sterpu, R., primary, Bosquet, A., additional, Medjkane, A., additional, Affo, L., additional, Vinceneux, P., additional, and Mahé, I., additional
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- 2008
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37. Le vote des patients hospitalisés en médecine interne : une étude prospective
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Bosquet, A., primary, Mahé, I., additional, Medjkane, A., additional, Warnecke, D. Voitel, additional, Manceron, V., additional, and Vinceneux, P., additional
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- 2008
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38. Localisation osseuse de la maladie de Kaposi sans atteinte cutanéomuqueuse contiguë : intérêt de la tomographie par émission de positons au fluorodéoxyglucose (18F)
- Author
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Paycha, F., primary, Mortier, E., additional, Sassi, R., additional, Mahjoub, W. Koubaa, additional, Huchet, V., additional, Vignali, J.-P., additional, Grossin, M., additional, Dion, E., additional, and Vinceneux, P., additional
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- 2008
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39. Une cause inhabituelle de varices œsophagiennes
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Bosquet, A., primary, Sterpu, R., additional, Medjkane, A., additional, Mahé, I., additional, and Vinceneux, P., additional
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- 2008
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40. Gale commune et anti-TNF
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Nocturne, G., primary, Grasland, A., additional, Dif, J., additional, Affo, L., additional, Bosquet, A., additional, and Vinceneux, P., additional
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- 2008
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41. Thrombopénie sévère et sarcoïdose
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Affo, C., primary, Pepin, M., additional, Grasland, A., additional, Medjkane, A., additional, Bosquet, A., additional, Voitel, D., additional, Manceron, V., additional, Mahé, I., additional, and Vinceneux, P., additional
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- 2008
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42. Les greffes à donneur vivant. Éthique du don
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Vinceneux, P., primary, Valla, D., additional, Durand, F., additional, and Belghiti, J., additional
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- 2008
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43. Une hypertrophie musculaire douloureuse
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Grasland, A., primary, Grossin, M., additional, and Vinceneux, P., additional
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- 2006
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44. Brain Abscess Caused by Nocardia cyriacigeorgica in a Patient with Human Immunodeficiency Virus Infection
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Barnaud, G., primary, Deschamps, C., additional, Manceron, V., additional, Mortier, E., additional, Laurent, F., additional, Bert, F., additional, Boiron, P., additional, Vinceneux, P., additional, and Branger, C., additional
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- 2005
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45. Maladie de Still et leucopénie : à propos de deux observations
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Rist, S., primary, Manceron, V., additional, Bartolucci, P., additional, Grasland, A., additional, Bosquet, A., additional, and Vinceneux, P., additional
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- 2005
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46. Conséquences de la substitution de l’indinavir par l’abacavir chez un patient infecté par le VIH en succès thérapeutique
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Gaba, S., primary, Mortier, E., additional, Branger, C., additional, and Vinceneux, P., additional
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- 2005
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47. Anomalies unguéales au cours d'une chimiothérapie pour cancer du sein
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Grasland, A., primary, Grandjean, M., additional, Rist, S., additional, Bosquet, A., additional, and Vinceneux, P., additional
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- 2005
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48. Cellulite communautaire de l'épaule à Staphylococcus aureus méticilline-résistant producteur de la leucocidine de Panton-Valentine
- Author
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Manceron, V., primary, Hidri, N., additional, Grasland, A., additional, and Vinceneux, P., additional
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- 2005
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49. Une hyperfixation myocardique sur une scintigraphie osseuse
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Grasland, A., primary, Ramadan, A., additional, Paycha, F., additional, Florens, E., additional, and Vinceneux, P., additional
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- 2004
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50. De l'air dans la paroi vésicale
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Raschilas, F, primary, Pierrot-Deseilligny, C, additional, Pouchot, J, additional, Sebag, A, additional, and Vinceneux, P, additional
- Published
- 2004
- Full Text
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