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Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries

Authors :
Lodi, Sara
Del Amo, Julia
Moreno, Santiago
Bucher, H. C.
Furrer, Hansjakob
Logan, Roger
Sterne, Jonathan
Pérez-Hoyos, Santiago
Jarrín, Inma
Phillips, Andrew
Olson, Ashley
Van Sighem, Ard
Reiss, Peter
Sabin, C.
Jose, Sophie
Justice, Amy
Goulet, Joseph
Miró, José M.
Ferrer, Elena
Meyer, Laurence
Seng, Rémonie
Vourli, Georgia
Antoniadou, Anastasia
Dabis, Francois
Vandenhede, Mari Anne
Costagliola, Dominique
Abgrall, S.
Hernán, Miguel A.
Hernan, Miguel
Bansi, L.
Hill, T.
Dunn, D.
Porter, K.
Glabay, A.
Orkin, C.
Thomas, R.
Jones, K.
Fisher, M.
Perry, N.
Pullin, A.
Churchill, D.
Gazzard, B.
Nelson, M.
Asboe, D.
Bulbeck, S.
Mandalia, S.
Clarke, J.
Delpech, V.
Anderson, J.
Munshi, S.
Post, F.
Easterbrook, P.
Khan, Y.
Patel, P.
Karim, F.
Duffell, S.
Gilson, R.
Man, S. L.
Williams, I.
Gompels, M.
Dooley, D.
Schwenk, A.
Ainsworth, J.
Johnson, M.
Youle, M.
Lampe, F.
Smith, C.
Grabowska, H.
Chaloner, C.
Ismajani Puradiredja, D.
Phillips, A.
Walsh, J.
Weber, J.
Kemble, C.
Mackie, N.
Winston, A.
Leen, C.
Wilson, A.
Bezemer, D. O.
Gras, L. A.J.
Kesselring, A. M.
Van Sighem, A. I.
Zaheri, S.
Van Twillert, G.
Kortmann, W.
Branger, J.
Prins, J. M.
Kuijpers, T. W.
Scherpbier, H. J.
Van Der Meer, J. T.M.
Wit, F. W.M.N.
Godfried, M. H.
Reiss, P.
Van Der Poll, T.
Nellen, F. J.B.
Lange, J. M.A.
Geerlings, S. E.
Van Vugt, M.
Pajkrt, D.
Bos, J. C.
Van Der Valk, M.
Grijsen, M. L.
Wiersinga, W. J.
Brinkman, K.
Blok, W. L.
Frissen, P. H.J.
Schouten, W. E.M.
Van Den Berk, G. E.L.
Veenstra, J.
Lettinga, K. D.
Mulder, J. W.
Vrouenraets, S. M.E.
Lauw, F. N.
Van Eeden, A.
Verhagen, D. W.M.
Van Agtmael, M. A.
Perenboom, R. M.
Claessen, F. A.P.
Bomers, M.
Peters, E. J.G.
Richter, C.
Van Der Berg, J. P.
Gisolf, E. H.
Schippers, E. F.
Van Nieuwkoop, C.
Van Elzakker, E. P.
Leyten, E. M.S.
Gelinck, L. B.S.
Pronk, M. J.H.
Bravenboer, B.
Kootstra, G. J.
Delsing, C. E.
Sprenger, H. G.
Doedens, R.
Scholvinck, E. H.
Van Assen, S.
Bierman, W. F.W.
Soetekouw, R.
Ten Kate, R. W.
Van Vonderen, M. G.A.
Van Houte, D. P.F.
Kroon, F. P.
Van Dissel, J. T.
Arend, S. M.
De Boer, M. G.J.
Jolink, H.
Ter Vollaard, H. J.M.
Bauer, M. P.
Weijer, S.
El Moussaoui, R.
Lowe, S.
Schreij, G.
Oude Lashof, A.
Posthouwer, D.
Koopmans, P. P.
Keuter, M.
Van Der Ven, A. J.A.M.
Ter Hofstede, H. J.M.
Dofferhoff, A. S.M.
Warris, A.
Van Crevel, R.
Van Der Ende, M. E.
De Vries-Sluijs, T. E.M.S.
Schurink, C. A.M.
Nouwen, J. L.
Nispen Tot Pannerden, M. H.
Verbon, A.
Rijnders, B. J.A.
Van Gorp, E. C.M.
Hassing, R. J.
Smeulders, A. W.M.
Hartwig, N. G.
Driessen, G. J.A.
Den Hollander, J. G.
Pogany, K.
Juttmann, J. R.
Van Kasteren, M. E.E.
Hoepelman, A. I.M.
Mudrikova, T.
Schneider, M. M.E.
Jaspers, C. A.J.J.
Ellerbroek, P. M.
Oosterheert, J. J.
Arends, J. E.
Wassenberg, M. W.M.
Barth, R. E.
Geelen, S. P.M.
Wolfs, T. F.W.
Bont, L. J.
Van Den Berge, M.
Stegeman, A.
Groeneveld, P. H.P.
Alleman, M. A.
Bouwhuis, J. W.
Barin, F.
Burty, C.
Duvivier, C.
Enel, P.
Fredouille-Heripret, L.
Gasnault, J.
Khuong, M. A.
Mahamat, A.
Pilorgé, F.
Tattevin, P.
Salomon, Valérie
Jacquemet, N.
Costagliola, D.
Grabar, S.
Guiguet, M.
Lanoy, E.
Lièvre, L.
Mary-Krause, M.
Selinger-Leneman, H.
Lacombe, J. M.
Potard, V.
Bricaire, F.
Herson, S.
Katlama, C.
Simon, A.
Desplanque, N.
Girard, P. M.
Meynard, J. L.
Meyohas, M. C.
Picard, O.
Cadranel, J.
Mayaud, C.
Pialoux, G.
Clauvel, J. P.
Decazes, J. M.
Gérard, L.
Molina, J. M.
Diemer, M.
Sellier, P.
Bentata, M.
Honoré, P.
Jeantils, V.
Tassi, S.
Mechali, D.
Taverne, B.
Bouvet, E.
Crickx, B.
Ecobichon, J. L.
Matheron, S.
Picard-Dahan, C.
Yeni, P.
Berthé, H.
Dupont, C.
Chandemerle, C.
Mortier, E.
De Truchis, P.
Tisne-Dessus, D.
Weiss, L.
Salmon, D.
Auperin, I.
Gilquin, J.
Roudière, L.
Viard, J. P.
Boue, F.
Fior, R.
Delfraissy, J. F.
Goujard, C.
Jung, C.
Lesprit, Ph
Vittecoq, D.
Fraisse, P.
Lang, J. M.
Rey, D.
Beck-Wirth, G.
Stahl, J. P.
Lecercq, P.
Gourdon, F.
Laurichesse, H.
Fresard, A.
Lucht, F.
Bazin, C.
Verdon, R.
Chavanet, P.
Arvieux, C.
Michelet, C.
Choutet, P.
Goudeau, A.
Maître, M. F.
Hoen, B.
Eglinger, P.
Faller, J. P.
Borsa-Lebas, F.
Caron, F.
Reynes, J.
Daures, J. P.
May, T.
Rabaud, C.
Berger, J. L.
Rémy, G.
Arlet-Suau, E.
Cuzin, L.
Massip, P.
Thiercelin Legrand, M. F.
Pontonnier, G.
Viget, N.
Yasdanpanah, Y.
Dellamonica, P.
Pradier, C.
Pugliese, P.
Aleksandrowicz, K.
Quinsat, D.
Ravaux, I.
Tissot-Dupont, H.
Delmont, J. P.
Moreau, J.
Gastaut, J. A.
Poizot Martin, I.
Retornaz, F.
Soubeyrand, J.
Galinier, A.
Ruiz, J. M.
Allegre, T.
Blanc, P. A.
Bonnet-Montchardon, D.
Lepeu, G.
Granet-Brunello, P.
Esterni, J. P.
Pelissier, L.
Cohen-Valensi, R.
Nezri, M.
Chadapaud, S.
Laffeuillade, A.
Billaud, E.
Raffi, F.
Boibieux, A.
Peyramond, D.
Livrozet, J. M.
Touraine, J. L.
Cotte, L.
Trepo, C.
Strobel, M.
Bissuel, F.
Pradinaud, R.
Sobesky, M.
Cabié, A.
Gaud, C.
Contant, M.
Aubert, V.
Barth, J.
Battegay, M.
Bernasconi, E.
Böni, J.
Burton-Jeangros, C.
Calmy, A.
Cavassini, M.
Egger, M.
Elzi, L.
Fehr, J.
Fellay, J.
Furrer, H.
Haerry, D.
Fux, C. A.
Gorgievski, M.
Günthard, H.
Hasse, B.
Hirsch, H. H.
Hösli, I.
Kahlert, C.
Kaiser, L.
Keiser, O.
Klimkait, T.
Kovari, H.
Ledergerber, B.
Martinetti, G.
Martinez De Tejada, B.
Metzner, K.
Müller, N.
Nadal, D.
Pantaleo, G.
Rauch, A.
Regenass, S.
Rickenbach, M.
Rudin, C.
Schmid, P.
Schultze, D.
Schöni-Affolter, F.
Schüpbach, J.
Speck, R.
Taffé, P.
Tarr, P.
Telenti, A.
Trkola, A.
Vernazza, P.
Weber, R.
Yerly, S.
Casabona, J.
Gallois, A.
Esteve, A.
Podzamczer, D.
Murillas, J.
Gatell, J. M.
Manzardo, C.
Tural, C.
Clotet, B.
Ferrer, E.
Riera, M.
Segura, F.
Navarro, G.
Force, L.
Vilaró, J.
Masabeu, A.
García, I.
Guadarrama, M.
Cifuentes, C.
Dalmau, D.
Jaen
Agustí, C.
Montoliu, A.
Pérez, I.
Gargoulas, Freyra
Blanco, J. L.
Garcia-Alcaide, F.
Martínez, E.
Mallolas, J.
López-Dieguez, M.
García-Goez, J. F.
Sirera, G.
Romeu, J.
Jou, A.
Negredo, E.
Miranda, C.
Capitan, M. C.
Saumoy, M.
Imaz, A.
Tiraboschi, J. M.
Murillo, O.
Bolao, F.
Peña, C.
Cabellos, C.
Masó, M.
Vila, A.
Sala, M.
Cervantes, M.
Jose Amengual, Ma
Navarro, M.
Penelo, E.
Barrufet, P.
Bejarano, G.
Molina, J.
Alvaro, M.
Mercadal, J.
Fernandez, Juanse
Ospina, Jesus E.
Muñoz, M. A.
Caro-Murillo, A. M.
Sobrino, P.
Jarrín, I.
Gomez Sirvent, J. L.
Rodríguez, P.
Aleman, M. R.
Alonso, M. M.
Lopez, A. M.
Hernandez, M. I.
Soriano, V.
Labarga, P.
Barreiro, P.
Medrano, J.
Rivas, P.
Herrero, D.
Blanco, F.
Vispo, M. E.
Martín, L.
Ramírez, G.
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Rubio, R.
Pulido, F.
Moreno, V.
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Iribarren, J. A.
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Aramburu, M. J.
Camino, X.
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Von Wichmann, M. A.
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Padilla, S.
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Goldberg, D.
Hawkins, D.
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Pillay, D.
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Louisa Gnatiuc, S. L.
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Fonquernie, L.
Lagneau, J. L.
Launay, O.
Pietrie, M. P.
Sicard, D.
Stieltjes, N.
Michot, J.
Bourdillon, F.
Obenga, G.
Escaut, L.
Bolliot, C.
Schneider, L.
Iguertsira, M.
Tomei, C.
Dhiver, C.
Tissot Dupont, H.
Vallon, A.
Gallais, J.
Gallais, H.
Durant, J.
Mondain, V.
Perbost, I.
Cassuto, J. P.
Karsenti, J. M.
Venti, H.
Ceppi, C.
Krivitsky, J. A.
Bouchaud, O.
Honore, P.
Delgado, J.
Rouzioux, C.
Burgard, M.
Boufassa, L.
Peynet, J.
Pérez-Hoyos, S.
Del Amo, J.
Alvarez, D.
Monge, S.
Muga, R.
Sanvisens, A.
Tor, J.
Rivas, I.
Vallecillo, G.
Del Romero, J.
Raposo, P.
Rodríguez, C.
Vera, M.
Hurtado, I.
Belda, J.
Fernandez, E.
Alastrue, I.
Santos, C.
Tasa, T.
Juan, A.
Trullen, J.
Garcia De Olalla, P.
Cayla, J.
Masdeu, E.
Knobel, H.
Mirò, J. M.
Sambeat, M. A.
Guerrero, R.
Rivera, E.
Marco, A.
Quintana, M.
Gonzalez, C.
Castilla, J.
Guevara, M.
De Mendoza, C.
Zahonero, N.
Ortíz, M.
Paraskevis, D.
Touloumi, G.
Pantazis, N.
Bakoyannis, G.
Gioukari, V.
Antoniadou, A.
Papadopoulos, A.
Petrikkos, G.
Daikos, G.
Psichogiou, M.
Gargalianos-Kakolyris, P.
Xylomenos, G.
Katsarou, O.
Kouramba, A.
Ioannidou, P.
Kordossis, T.
Kontos, A.
Lazanas, M.
Chini, M.
Tsogas, N.
Panos, G.
Paparizos, V.
Leuow, K.
Kourkounti, S.
Sambatakou, H.
Mariolis, I.
Skoutelis, A.
Papastamopoulos, V.
Baraboutis, I.
Internal medicine
APH - Aging & Later Life
Pediatric surgery
CCA - Innovative therapy
ICaR - Circulation and metabolism
ICaR - Ischemia and repair
Graduate School
Paediatric Infectious Diseases / Rheumatology / Immunology
Landsteiner Laboratory
AII - Amsterdam institute for Infection and Immunity
Infectious diseases
Global Health
Center of Experimental and Molecular Medicine
APH - Amsterdam Public Health
AII - Inflammatory diseases
ARD - Amsterdam Reproduction and Development
Source :
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initiating combination antiretroviral therapy in high-income countries ', AIDS, vol. 28, no. 16, pp. 2461-2473 . https://doi.org/10.1097/QAD.0000000000000456, AIDS, 28(16), 2461-2473. Lippincott Williams and Wilkins
Publication Year :
2014

Abstract

Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, hadCD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90-1.63) for tuberculosis, 2.61 (1.05-6.49) for MAC, 1.17 (0.34-4.08) for CMV retinitis, 1.18 (0.62-2.26) for PML, 1.21 (0.83-1.75) for HSV, 1.18 (0.87-1.58) for Kaposi sarcoma, 1.56 (0.82-2.95) for NHL, 1.11 (0.56-2.18) for cryptococcosis and 0.77 (0.40-1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.

Details

Language :
English
ISSN :
02699370
Database :
OpenAIRE
Journal :
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Accession number :
edsair.doi.dedup.....636d698af1b47a97a731f95f07f34643