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Your search keyword '"Viktor F Mautner"' showing total 3 results
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3 results on '"Viktor F Mautner"'

1. Sarcoma classification by DNA methylation profiling

Author

Christian Koelsche, Daniel Schrimpf, Damian Stichel, Martin Sill, Felix Sahm, David E. Reuss, Mirjam Blattner, Barbara Worst, Christoph E. Heilig, Katja Beck, Peter Horak, Simon Kreutzfeldt, Elke Paff, Sebastian Stark, Pascal Johann, Florian Selt, Jonas Ecker, Dominik Sturm, Kristian W. Pajtler, Annekathrin Reinhardt, Annika K. Wefers, Philipp Sievers, Azadeh Ebrahimi, Abigail Suwala, Francisco Fernández-Klett, Belén Casalini, Andrey Korshunov, Volker Hovestadt, Felix K. F. Kommoss, Mark Kriegsmann, Matthias Schick, Melanie Bewerunge-Hudler, Till Milde, Olaf Witt, Andreas E. Kulozik, Marcel Kool, Laura Romero-Pérez, Thomas G. P. Grünewald, Thomas Kirchner, Wolfgang Wick, Michael Platten, Andreas Unterberg, Matthias Uhl, Amir Abdollahi, Jürgen Debus, Burkhard Lehner, Christian Thomas, Martin Hasselblatt, Werner Paulus, Christian Hartmann, Ori Staszewski, Marco Prinz, Jürgen Hench, Stephan Frank, Yvonne M. H. Versleijen-Jonkers, Marije E. Weidema, Thomas Mentzel, Klaus Griewank, Enrique de Álava, Juan Díaz Martín, Miguel A. Idoate Gastearena, Kenneth Tou-En Chang, Sharon Yin Yee Low, Adrian Cuevas-Bourdier, Michel Mittelbronn, Martin Mynarek, Stefan Rutkowski, Ulrich Schüller, Viktor F. Mautner, Jens Schittenhelm, Jonathan Serrano, Matija Snuderl, Reinhard Büttner, Thomas Klingebiel, Rolf Buslei, Manfred Gessler, Pieter Wesseling, Winand N. M. Dinjens, Sebastian Brandner, Zane Jaunmuktane, Iben Lyskjær, Peter Schirmacher, Albrecht Stenzinger, Benedikt Brors, Hanno Glimm, Christoph Heining, Oscar M. Tirado, Miguel Sáinz-Jaspeado, Jaume Mora, Javier Alonso, Xavier Garcia del Muro, Sebastian Moran, Manel Esteller, Jamal K. Benhamida, Marc Ladanyi, Eva Wardelmann, Cristina Antonescu, Adrienne Flanagan, Uta Dirksen, Peter Hohenberger, Daniel Baumhoer, Wolfgang Hartmann, Christian Vokuhl, Uta Flucke, Iver Petersen, Gunhild Mechtersheimer, David Capper, David T. W. Jones, Stefan Fröhling, Stefan M. Pfister, and Andreas von Deimling

Subjects
Science
Abstract

Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.

Published
2021
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2. Neurofibromatosis type 2 predisposes to ependymomas of various localization, histology, and molecular subtype

Author

Abigail K. Suwala, Leonille Schweizer, Brigitte Bison, Annika K. Wefers, Christian Hagel, Andreas von Deimling, Katja Kloth-Stachnau, Lara Engertsberger, Martin Mynarek, Michael Spohn, Catena Kresbach, Martin Benesch, Stefan Rutkowski, Ulrich Schüller, Viktor-F Mautner, and Mario M. Dorostkar

Subjects
Adult, Male, genetics [Ependymoma], Pathology, medicine.medical_specialty, Neurofibromatosis 2, genetics [Central Nervous System Neoplasms], Adolescent, MEDLINE, genetics [DNA Methylation], Pathology and Forensic Medicine, Central Nervous System Neoplasms, Cellular and Molecular Neuroscience, Text mining, Genes, Neurofibromatosis 2, Correspondence, medicine, Humans, pathology [Neurofibromatosis 2], Neurosciences, ddc:610, Neurofibromatosis type 2, Child, genetics [Neurofibromatosis 2], business.industry, pathology [Ependymoma], pathology [Central Nervous System Neoplasms], Histology, DNA Methylation, medicine.disease, Magnetic Resonance Imaging, diagnostic imaging [Central Nervous System Neoplasms], complications [Neurofibromatosis 2], Ependymoma, Child, Preschool, Mutation, Female, Neurology (clinical), business, diagnostic imaging [Ependymoma]
Published
2021

3. EPEN-27. Epigenetic dissection of spinal ependymomas (SP-EPN) separates tumors with and withoutNF2 mutation

Author

Sina Neyazi, Erika Yamazawa, Catena Kresbach, Genta Nagae, Alicia Eckhardt, Takayoshi Umeda, Lara Pohl, Kenji Tatsuno, Ceren Saygi, Taijun Hana, Malik Alawi, Phyo Kim, Mario M Dorostkar, Fumi Higuchi, Abigail K Suwala, Toshihiro Takami, Annika Wefers, Yuta Nakanishi, Leonille Schweizer, Keisuke Takai, Lara Engertsberger, Takashi Komori, Theresa Mohme, Hirokazu Takami, Martin Mynarek, Masashi Nomura, Karin Lamszus, Akitake Mukasa, Lan Kluwe, Shunsaku Takayanagi, Andreas von Deimling, Kazuhiko Ishii, Martin Benesch, Hideaki Imai, Matija Snuderl, Stephan Frank, Koichi Ichimura, Christian Hagel, Viktor F Mautner, Stefan Rutkowski, Shota Tanaka, Hiroyuki Aburatani, Saito Nobuhito, and Ulrich Schüller

Subjects
Cancer Research, Oncology, Neurology (clinical)
Abstract

Ependymomas encompass multiple, clinically relevant tumor types based on localization, genetic alterations, and epigenetic and transcriptomic profiles. Tumors belonging to the methylation class of spinal ependymoma (SP-EPN) represent the most common intramedullary neoplasms in children and adults. However, molecular data of SP-EPN are scarce, and clear treatment recommendations are lacking. The only known recurrent genetic events in SP-EPN are loss of chromosome 22q and NF2 mutations. Yet, it remains unclear whether SP-EPN with germline or sporadic NF2 mutations or with NF2 wild type status differ clinically or molecularly. To provide a comprehensive molecular profile of SP-EPN, we integrated epigenetic, genomic, transcriptomic, and histological analyses of up to 237 cases. Clustering of methylation data revealed two distinct molecular SP-EPN subtypes. The distribution of NF2 mutated cases differed significantly across these subtypes (p

Published
2022

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