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Sarcoma classification by DNA methylation profiling

Authors :
Christian Koelsche
Daniel Schrimpf
Damian Stichel
Martin Sill
Felix Sahm
David E. Reuss
Mirjam Blattner
Barbara Worst
Christoph E. Heilig
Katja Beck
Peter Horak
Simon Kreutzfeldt
Elke Paff
Sebastian Stark
Pascal Johann
Florian Selt
Jonas Ecker
Dominik Sturm
Kristian W. Pajtler
Annekathrin Reinhardt
Annika K. Wefers
Philipp Sievers
Azadeh Ebrahimi
Abigail Suwala
Francisco Fernández-Klett
Belén Casalini
Andrey Korshunov
Volker Hovestadt
Felix K. F. Kommoss
Mark Kriegsmann
Matthias Schick
Melanie Bewerunge-Hudler
Till Milde
Olaf Witt
Andreas E. Kulozik
Marcel Kool
Laura Romero-Pérez
Thomas G. P. Grünewald
Thomas Kirchner
Wolfgang Wick
Michael Platten
Andreas Unterberg
Matthias Uhl
Amir Abdollahi
Jürgen Debus
Burkhard Lehner
Christian Thomas
Martin Hasselblatt
Werner Paulus
Christian Hartmann
Ori Staszewski
Marco Prinz
Jürgen Hench
Stephan Frank
Yvonne M. H. Versleijen-Jonkers
Marije E. Weidema
Thomas Mentzel
Klaus Griewank
Enrique de Álava
Juan Díaz Martín
Miguel A. Idoate Gastearena
Kenneth Tou-En Chang
Sharon Yin Yee Low
Adrian Cuevas-Bourdier
Michel Mittelbronn
Martin Mynarek
Stefan Rutkowski
Ulrich Schüller
Viktor F. Mautner
Jens Schittenhelm
Jonathan Serrano
Matija Snuderl
Reinhard Büttner
Thomas Klingebiel
Rolf Buslei
Manfred Gessler
Pieter Wesseling
Winand N. M. Dinjens
Sebastian Brandner
Zane Jaunmuktane
Iben Lyskjær
Peter Schirmacher
Albrecht Stenzinger
Benedikt Brors
Hanno Glimm
Christoph Heining
Oscar M. Tirado
Miguel Sáinz-Jaspeado
Jaume Mora
Javier Alonso
Xavier Garcia del Muro
Sebastian Moran
Manel Esteller
Jamal K. Benhamida
Marc Ladanyi
Eva Wardelmann
Cristina Antonescu
Adrienne Flanagan
Uta Dirksen
Peter Hohenberger
Daniel Baumhoer
Wolfgang Hartmann
Christian Vokuhl
Uta Flucke
Iver Petersen
Gunhild Mechtersheimer
David Capper
David T. W. Jones
Stefan Fröhling
Stefan M. Pfister
Andreas von Deimling
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.88e43d5043848c8bc27777e780e6d5b
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-20603-4