90 results on '"Vignale, D"'
Search Results
2. In Patients Undergoing Tavi, Imaging Biomarkers Derived From Preoperative Ct Scan Predict Long Term Prognosis
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Vignale, D., primary, Palmisano, A., additional, Gnasso, C., additional, Margonato, D., additional, Ingallina, G., additional, Barbieri, S., additional, Agricola, E., additional, and Esposito, A., additional
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- 2024
- Full Text
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3. Immunomodulation to target biopsy-proven myocardial inflammation in genetic cardiomyopathies: a pilot report
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Peretto, G, primary, De Luca, G, additional, Di Resta, C, additional, Campochiaro, C, additional, Villatore, A, additional, Palmisano, A, additional, Vignale, D, additional, Busnardo, E, additional, Lazzeroni, D, additional, Rizzo, S, additional, Sala, S, additional, Esposito, A, additional, Basso, C, additional, Dagna, L, additional, and Della Bella, P, additional
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- 2023
- Full Text
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4. Chest CT opportunistic biomarkers for phenotyping high-risk COVID-19 patients: a retrospective multicentre study
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Palmisano, A, Gnasso, C, Cereda, A, Vignale, D, Leone, R, Nicoletti, V, Barbieri, S, Toselli, M, Giannini, F, Loffi, M, Patelli, G, Monello, A, Iannopollo, G, Ippolito, D, Mancini, E, Pontone, G, Vignali, L, Scarnecchia, E, Iannaccone, M, Baffoni, L, Spernadio, M, de Carlini, C, Sironi, S, Rapezzi, C, Esposito, A, Palmisano A., Gnasso C., Cereda A., Vignale D., Leone R., Nicoletti V., Barbieri S., Toselli M., Giannini F., Loffi M., Patelli G., Monello A., Iannopollo G., Ippolito D., Mancini E. M., Pontone G., Vignali L., Scarnecchia E., Iannaccone M., Baffoni L., Spernadio M., de Carlini C. C., Sironi S., Rapezzi C., Esposito A., Palmisano, A, Gnasso, C, Cereda, A, Vignale, D, Leone, R, Nicoletti, V, Barbieri, S, Toselli, M, Giannini, F, Loffi, M, Patelli, G, Monello, A, Iannopollo, G, Ippolito, D, Mancini, E, Pontone, G, Vignali, L, Scarnecchia, E, Iannaccone, M, Baffoni, L, Spernadio, M, de Carlini, C, Sironi, S, Rapezzi, C, Esposito, A, Palmisano A., Gnasso C., Cereda A., Vignale D., Leone R., Nicoletti V., Barbieri S., Toselli M., Giannini F., Loffi M., Patelli G., Monello A., Iannopollo G., Ippolito D., Mancini E. M., Pontone G., Vignali L., Scarnecchia E., Iannaccone M., Baffoni L., Spernadio M., de Carlini C. C., Sironi S., Rapezzi C., and Esposito A.
- Abstract
Objective: To assess the value of opportunistic biomarkers derived from chest CT performed at hospital admission of COVID-19 patients for the phenotypization of high-risk patients. Methods: In this multicentre retrospective study, 1845 consecutive COVID-19 patients with chest CT performed within 72 h from hospital admission were analysed. Clinical and outcome data were collected by each center 30 and 80 days after hospital admission. Patients with unknown outcomes were excluded. Chest CT was analysed in a single core lab and behind pneumonia CT scores were extracted opportunistic data about atherosclerotic profile (calcium score according to Agatston method), liver steatosis (≤ 40 HU), myosteatosis (paraspinal muscle F < 31.3 HU, M < 37.5 HU), and osteoporosis (D12 bone attenuation < 134 HU). Differences according to treatment and outcome were assessed with ANOVA. Prediction models were obtained using multivariate binary logistic regression and their AUCs were compared with the DeLong test. Results: The final cohort included 1669 patients (age 67.5 [58.5–77.4] yo) mainly men 1105/1669, 66.2%) and with reduced oxygen saturation (92% [88–95%]). Pneumonia severity, high Agatston score, myosteatosis, liver steatosis, and osteoporosis derived from CT were more prevalent in patients with more aggressive treatment, access to ICU, and in-hospital death (always p < 0.05). A multivariable model including clinical and CT variables improved the capability to predict non-critical pneumonia compared to a model including only clinical variables (AUC 0.801 vs 0.789; p = 0.0198) to predict patient death (AUC 0.815 vs 0.800; p = 0.001). Conclusion: Opportunistic biomarkers derived from chest CT can improve the characterization of COVID-19 high-risk patients. Clinical relevance statement: In COVID-19 patients, opportunistic biomarkers of cardiometabolic risk extracted from chest CT improve patient risk stratification. Key Points: • In COVID-19 patients, several i
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- 2023
5. AI-SCoRE (artificial intelligence-SARS CoV2 risk evaluation): a fast, objective and fully automated platform to predict the outcome in COVID-19 patients
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Palmisano, A, Vignale, D, Boccia, E, Nonis, A, Gnasso, C, Leone, R, Montagna, M, Nicoletti, V, Bianchi, A, Brusamolino, S, Dorizza, A, Moraschini, M, Veettil, R, Cereda, A, Toselli, M, Giannini, F, Loffi, M, Patelli, G, Monello, A, Iannopollo, G, Ippolito, D, Mancini, E, Pontone, G, Vignali, L, Scarnecchia, E, Iannacone, M, Baffoni, L, Sperandio, M, de Carlini, C, Sironi, S, Rapezzi, C, Antiga, L, Jagher, V, Di Serio, C, Furlanello, C, Tacchetti, C, Esposito, A, Palmisano A., Vignale D., Boccia E., Nonis A., Gnasso C., Leone R., Montagna M., Nicoletti V., Bianchi A. G., Brusamolino S., Dorizza A., Moraschini M., Veettil R., Cereda A., Toselli M., Giannini F., Loffi M., Patelli G., Monello A., Iannopollo G., Ippolito D., Mancini E. M., Pontone G., Vignali L., Scarnecchia E., Iannacone M., Baffoni L., Sperandio M., de Carlini C. C., Sironi S., Rapezzi C., Antiga L., Jagher V., Di Serio C., Furlanello C., Tacchetti C., Esposito A., Palmisano, A, Vignale, D, Boccia, E, Nonis, A, Gnasso, C, Leone, R, Montagna, M, Nicoletti, V, Bianchi, A, Brusamolino, S, Dorizza, A, Moraschini, M, Veettil, R, Cereda, A, Toselli, M, Giannini, F, Loffi, M, Patelli, G, Monello, A, Iannopollo, G, Ippolito, D, Mancini, E, Pontone, G, Vignali, L, Scarnecchia, E, Iannacone, M, Baffoni, L, Sperandio, M, de Carlini, C, Sironi, S, Rapezzi, C, Antiga, L, Jagher, V, Di Serio, C, Furlanello, C, Tacchetti, C, Esposito, A, Palmisano A., Vignale D., Boccia E., Nonis A., Gnasso C., Leone R., Montagna M., Nicoletti V., Bianchi A. G., Brusamolino S., Dorizza A., Moraschini M., Veettil R., Cereda A., Toselli M., Giannini F., Loffi M., Patelli G., Monello A., Iannopollo G., Ippolito D., Mancini E. M., Pontone G., Vignali L., Scarnecchia E., Iannacone M., Baffoni L., Sperandio M., de Carlini C. C., Sironi S., Rapezzi C., Antiga L., Jagher V., Di Serio C., Furlanello C., Tacchetti C., and Esposito A.
- Abstract
Purpose: To develop and validate an effective and user-friendly AI platform based on a few unbiased clinical variables integrated with advanced CT automatic analysis for COVID-19 patients’ risk stratification. Material and Methods: In total, 1575 consecutive COVID-19 adults admitted to 16 hospitals during wave 1 (February 16-April 29, 2020), submitted to chest CT within 72 h from admission, were retrospectively enrolled. In total, 107 variables were initially collected; 64 extracted from CT. The outcome was survival. A rigorous AI model selection framework was adopted for models selection and automatic CT data extraction. Model performances were compared in terms of AUC. A web–mobile interface was developed using Microsoft PowerApps environment. The platform was externally validated on 213 COVID-19 adults prospectively enrolled during wave 2 (October 14-December 31, 2020). Results: The final cohort included 1125 patients (292 non-survivors, 26%) and 24 variables. Logistic showed the best performance on the complete set of variables (AUC = 0.839 ± 0.009) as in models including a limited set of 13 and 5 variables (AUC = 0.840 ± 0.0093 and AUC = 0.834 ± 0.007). For non-inferior performance, the 5 variables model (age, sex, saturation, well-aerated lung parenchyma and cardiothoracic vascular calcium) was selected as the final model and the extraction of CT-derived parameters was fully automatized. The fully automatic model showed AUC = 0.842 (95% CI: 0.816–0.867) on wave 1 and was used to build a 0–100 scale risk score (AI-SCoRE). The predictive performance was confirmed on wave 2 (AUC 0.808; 95% CI: 0.7402–0.8766). Conclusions: AI-SCoRE is an effective and reliable platform for automatic risk stratification of COVID-19 patients based on a few unbiased clinical data and CT automatic analysis.
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- 2022
6. The hidden interplay between sex and COVID-19 mortality: the role of cardiovascular calcification
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Cereda, A, Toselli, M, Palmisano, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Mangieri, A, Khokhar, A, Campo, G, Scoccia, A, Bertini, M, Loffi, M, Sergio, P, Andreini, D, Pontone, G, Iannopollo, G, Nannini, T, Ippolito, D, Bellani, G, Patelli, G, Besana, F, Vignali, L, Sverzellati, N, Iannaccone, M, Vaudano, P, Sangiorgi, G, Turchio, P, Monello, A, Tumminello, G, Maggioni, A, Rapezzi, C, Colombo, A, Giannini, F, Esposito, A, Cereda A., Toselli M., Palmisano A., Vignale D., Leone R., Nicoletti V., Gnasso C., Mangieri A., Khokhar A., Campo G., Scoccia A., Bertini M., Loffi M., Sergio P., Andreini D., Pontone G., Iannopollo G., Nannini T., Ippolito D., Bellani G., Patelli G., Besana F., Vignali L., Sverzellati N., Iannaccone M., Vaudano P. G., Sangiorgi G. M., Turchio P., Monello A., Tumminello G., Maggioni A. P., Rapezzi C., Colombo A., Giannini F., Esposito A., Cereda, A, Toselli, M, Palmisano, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Mangieri, A, Khokhar, A, Campo, G, Scoccia, A, Bertini, M, Loffi, M, Sergio, P, Andreini, D, Pontone, G, Iannopollo, G, Nannini, T, Ippolito, D, Bellani, G, Patelli, G, Besana, F, Vignali, L, Sverzellati, N, Iannaccone, M, Vaudano, P, Sangiorgi, G, Turchio, P, Monello, A, Tumminello, G, Maggioni, A, Rapezzi, C, Colombo, A, Giannini, F, Esposito, A, Cereda A., Toselli M., Palmisano A., Vignale D., Leone R., Nicoletti V., Gnasso C., Mangieri A., Khokhar A., Campo G., Scoccia A., Bertini M., Loffi M., Sergio P., Andreini D., Pontone G., Iannopollo G., Nannini T., Ippolito D., Bellani G., Patelli G., Besana F., Vignali L., Sverzellati N., Iannaccone M., Vaudano P. G., Sangiorgi G. M., Turchio P., Monello A., Tumminello G., Maggioni A. P., Rapezzi C., Colombo A., Giannini F., and Esposito A.
- Abstract
Recent clinical and demographical studies on COVID-19 patients have demonstrated that men experience worse outcomes than women. However, in most cases, the data were not stratified according to gender, limiting the understanding of the real impact of gender on outcomes. This study aimed to evaluate the disaggregated in-hospital outcomes and explore the possible interactions between gender and cardiovascular calcifications. Data was derived from the sCORE-COVID-19 registry, an Italian multicentre registry that enrolled COVID-19 patients who had undergone a chest computer tomography scan on admission. A total of 1683 hospitalized patients (mean age 67±14 years) were included. Men had a higher prevalence of cardiovascular comorbidities, a higher pneumonia extension, more coronary calcifications (63% vs.50.9%, p<0.001), and a higher coronary calcium score (391±847 vs. 171±479 mm3, p<0.001). Men experienced a significantly higher mortality rate (24.4% vs. 17%, p=0.001), but the death event tended to occur earlier in women (15±7 vs. 8±7 days, p= 0.07). Non-survivors had a higher coronary, thoracic aorta, and aortic valve calcium score. Female sex, a known independent predictor of a favorable outcome in SARS-CoV2 infection, was not protective in women with a coronary calcification volume greater than 100 mm3. There were significant differences in cardiovascular comorbidities and vascular calcifications between men and women with SARS-CoV2 pneumonia. The differences in outcomes can be at least partially explained by the different cardiovascular profiles. However, women with poor outcomes had the same coronary calcific burden as men. The presumed favorable female sex bias in COVID-19 must therefore be reviewed in the context of comorbidities, especially cardiovascular ones.
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- 2021
7. Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19
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Scoccia, A, Gallone, G, Cereda, A, Palmisano, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Khokhar, A, Sticchi, A, Biagi, A, Tacchetti, C, Campo, G, Rapezzi, C, Ponticelli, F, Danzi, G, Loffi, M, Pontone, G, Andreini, D, Casella, G, Iannopollo, G, Ippolito, D, Bellani, G, Patelli, G, Besana, F, Costa, C, Vignali, L, Benatti, G, Iannaccone, M, Vaudano, P, Pacielli, A, De Carlini, C, Maggiolini, S, Bonaffini, P, Senni, M, Scarnecchia, E, Anastasio, F, Colombo, A, Ferrari, R, Esposito, A, Giannini, F, Toselli, M, Scoccia A., Gallone G., Cereda A., Palmisano A., Vignale D., Leone R., Nicoletti V., Gnasso C., Monello A., Khokhar A., Sticchi A., Biagi A., Tacchetti C., Campo G., Rapezzi C., Ponticelli F., Danzi G. B., Loffi M., Pontone G., Andreini D., Casella G., Iannopollo G., Ippolito D., Bellani G., Patelli G., Besana F., Costa C., Vignali L., Benatti G., Iannaccone M., Vaudano P. G., Pacielli A., De Carlini C. C., Maggiolini S., Bonaffini P. A., Senni M., Scarnecchia E., Anastasio F., Colombo A., Ferrari R., Esposito A., Giannini F., Toselli M., Scoccia, A, Gallone, G, Cereda, A, Palmisano, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Khokhar, A, Sticchi, A, Biagi, A, Tacchetti, C, Campo, G, Rapezzi, C, Ponticelli, F, Danzi, G, Loffi, M, Pontone, G, Andreini, D, Casella, G, Iannopollo, G, Ippolito, D, Bellani, G, Patelli, G, Besana, F, Costa, C, Vignali, L, Benatti, G, Iannaccone, M, Vaudano, P, Pacielli, A, De Carlini, C, Maggiolini, S, Bonaffini, P, Senni, M, Scarnecchia, E, Anastasio, F, Colombo, A, Ferrari, R, Esposito, A, Giannini, F, Toselli, M, Scoccia A., Gallone G., Cereda A., Palmisano A., Vignale D., Leone R., Nicoletti V., Gnasso C., Monello A., Khokhar A., Sticchi A., Biagi A., Tacchetti C., Campo G., Rapezzi C., Ponticelli F., Danzi G. B., Loffi M., Pontone G., Andreini D., Casella G., Iannopollo G., Ippolito D., Bellani G., Patelli G., Besana F., Costa C., Vignali L., Benatti G., Iannaccone M., Vaudano P. G., Pacielli A., De Carlini C. C., Maggiolini S., Bonaffini P. A., Senni M., Scarnecchia E., Anastasio F., Colombo A., Ferrari R., Esposito A., Giannini F., and Toselli M.
- Abstract
Background and aims: The potential impact of coronary atherosclerosis, as detected by coronary artery calcium, on clinical outcomes in COVID-19 patients remains unsettled. We aimed to evaluate the prognostic impact of clinical and subclinical coronary artery disease (CAD), as assessed by coronary artery calcium score (CAC), in a large, unselected population of hospitalized COVID-19 patients undergoing non-gated chest computed tomography (CT) for clinical practice. Methods: SARS-CoV 2 positive patients from the multicenter (16 Italian hospitals), retrospective observational SCORE COVID-19 (calcium score for COVID-19 Risk Evaluation) registry were stratified in three groups: (a) “clinical CAD” (prior revascularization history), (b) “subclinical CAD” (CAC >0), (c) “No CAD” (CAC = 0). Primary endpoint was in-hospital mortality and the secondary endpoint was a composite of myocardial infarction and cerebrovascular accident (MI/CVA). Results: Amongst 1625 patients (male 67.2%, median age 69 [interquartile range 58–77] years), 31%, 57.8% and 11.1% had no, subclinical and clinical CAD, respectively. Increasing rates of in-hospital mortality (11.3% vs. 27.3% vs. 39.8%, p < 0.001) and MI/CVA events (2.3% vs. 3.8% vs. 11.9%, p < 0.001) were observed for patients with no CAD vs. subclinical CAD vs clinical CAD, respectively. The association with in-hospital mortality was independent of in-study outcome predictors (age, peripheral artery disease, active cancer, hemoglobin, C-reactive protein, LDH, aerated lung volume): subclinical CAD vs. No CAD: adjusted hazard ratio (adj-HR) 2.86 (95% confidence interval [CI] 1.14–7.17, p=0.025); clinical CAD vs. No CAD: adj-HR 3.74 (95% CI 1.21–11.60, p=0.022). Among patients with subclinical CAD, increasing CAC burden was associated with higher rates of in-hospital mortality (20.5% vs. 27.9% vs. 38.7% for patients with CAC score thresholds≤100, 101–400 and > 400, respectively, p < 0.001). The adj-HR per 50 points increase in C
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- 2021
8. Is pleural effusion in COVID-19 interstitial pneumonia related to in-hospital mortality?
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Cereda, A, Toselli, M, Palmisano, A, Leone, R, Vignale, D, Nicoletti, V, Campo, G, Monello, A, Ippolito, D, Giannini, F, Esposito, A, Cereda A., Toselli M., Palmisano A., Leone R., Vignale D., Nicoletti V., Campo G., Monello A., Ippolito D., Giannini F., Esposito A., Cereda, A, Toselli, M, Palmisano, A, Leone, R, Vignale, D, Nicoletti, V, Campo, G, Monello, A, Ippolito, D, Giannini, F, Esposito, A, Cereda A., Toselli M., Palmisano A., Leone R., Vignale D., Nicoletti V., Campo G., Monello A., Ippolito D., Giannini F., and Esposito A.
- Abstract
The recent severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) pandemic has highlighted the importance of pulmonary computed tomography (CT) for diagnosis and prognostic stratification of this new viral pneumonia. 1370 lung CT scans (performed at the time of admission) of consecutive patients hospitalized for SARS-CoV-2 in Northern Italy during the first epidemic wave were analyzed by a radiological CoreLab. The presence of pleural effusion on pulmonary CT scan was present in 188 patients (13.3% of the population) and identified a population with more comorbidities. Patients with pleural effusion had more cardio-respiratory complications with higher mortality. Pleural effusion was an independent predictor of death on multivariate analysis with an HR of 1.4 (95% confidence interval 1-1.9). Pulmonary CT pleural effusion was an independent predictor of mortality.
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- 2021
9. Dynamic changes of mitral valve annulus geometry at preprocedural CT: relationship with functional classes of regurgitation
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Palmisano A., Nicoletti V., Colantoni C., Monti C. B., Pannone L., Vignale D., Darvizeh F., Agricola E., Schaffino S., De Cobelli F., Esposito A., Palmisano, A., Nicoletti, V., Colantoni, C., Monti, C. B., Pannone, L., Vignale, D., Darvizeh, F., Agricola, E., Schaffino, S., De Cobelli, F., and Esposito, A.
- Subjects
Mitral valve ,Planning techniques ,Computed tomography angiography ,Heart valve prosthesis ,Mitral valve insufficiency - Abstract
Background: We investigated mitral valve annular geometry changes during thecardiac cycle in patients with severe mitral regurgitation (MR) who underwent cardiac computed tomography angiography (CCTA) prior to percutaneous mitral valve replacement or annuloplasty. Methods: Fifty-one patients with severe MR and high surgical risk (Carpentier classification: 3 type I, 16 type II, 16 type IIIa, 16 type IIIb) underwent multiphase electrocardiographically gated (0–90%) CCTA, using a second generation dual-source CT scanner, as pre-procedural planning. Twenty-one patients without MR served as controls. The mitral valve annulus was segmented every 10% step of the R-R interval, according to the D-shaped segmentation model, and differences among groups were analysed by t-test or ANOVA. Results: Mitral annular area and diameters were larger in MR patients compared to controls, particularly in type II. Mitral annular area varied in MR patients throughout the cardiac cycle (mean ± standard deviation of maximum and minimum area 15.6 ± 3.9 cm2versus 13.0 ± 3.5 cm2, respectively; p = 0.001), with greater difference between annular areas versus controls (2.59 ± 1.61 cm2 and 1.98 ± 0.6 cm2, p < 0.001). The largest dimension was found in systolic phases (20–40%) in most of MR patients (n = 27, 53%), independent of Carpentier type (I: n = 1, 33%; II: n = 10, 63%; IIIa: n = 8, 50%; IIIb: n = 8, 50%), andin protodiastolic phases (n = 14, 67%) for the control group. Conclusions: In severe MR, mitral annular area varied significantly throughout the cardiac cycle, with a tendency towards larger dimensions in systole.
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- 2021
10. Severe acute respiratory syndrome coronavirus-2-induced flare of systemic sclerosis
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Campochiaro, C, primary, De Luca, G, additional, Farina, N, additional, Vignale, D, additional, Palmisano, A, additional, Matucci-Cerinic, M, additional, and Dagna, L, additional
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- 2021
- Full Text
- View/download PDF
11. Coronary and total thoracic calcium scores predict mortality and provides pathophysiologic insights in COVID-19 patients
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Giannini, F, Toselli, M, Palmisano, A, Cereda, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Manfrini, M, Khokhar, A, Sticchi, A, Biagi, A, Turchio, P, Tacchetti, C, Landoni, G, Boccia, E, Campo, G, Scoccia, A, Ponticelli, F, Danzi, G, Loffi, M, Muri, M, Pontone, G, Andreini, D, Mancini, E, Casella, G, Iannopollo, G, Nannini, T, Ippolito, D, Bellani, G, Franzesi, C, Patelli, G, Besana, F, Costa, C, Vignali, L, Benatti, G, Sverzellati, N, Scarnecchia, E, Lombardo, F, Anastasio, F, Iannaccone, M, Vaudano, P, Pacielli, A, Baffoni, L, Gardi, I, Cesini, E, Sperandio, M, Micossi, C, De Carlini, C, Spreafico, C, Maggiolini, S, Bonaffini, P, Iacovoni, A, Sironi, S, Senni, M, Fominskiy, E, De Cobelli, F, Maggioni, A, Rapezzi, C, Ferrari, R, Colombo, A, Esposito, A, Giannini, Francesco, Toselli, Marco, Palmisano, Anna, Cereda, Alberto, Vignale, Davide, Leone, Riccardo, Nicoletti, Valeria, Gnasso, Chiara, Monello, Alberto, Manfrini, Marco, Khokhar, Arif, Sticchi, Alessandro, Biagi, Andrea, Turchio, Piergiorgio, Tacchetti, Carlo, Landoni, Giovanni, Boccia, Edda, Campo, Gianluca, Scoccia, Alessandra, Ponticelli, Francesco, Danzi, Gian Battista, Loffi, Marco, Muri, Margherita, Pontone, Gianluca, Andreini, Daniele, Mancini, Elisabetta Maria, Casella, Gianni, Iannopollo, Gianmarco, Nannini, Tommaso, Ippolito, Davide, Bellani, Giacomo, Franzesi, Camillo Talei, Patelli, Gianluigi, Besana, Francesca, Costa, Claudia, Vignali, Luigi, Benatti, Giorgio, Sverzellati, Nicola, Scarnecchia, Elisa, Lombardo, Francesco Paolo, Anastasio, Fabio, Iannaccone, Mario, Vaudano, Paolo Giacomo, Pacielli, Alberto, Baffoni, Lucio, Gardi, Iljia, Cesini, Elisabetta, Sperandio, Massimiliano, Micossi, Chiara, De Carlini, Caterina Chiara, Spreafico, Cristiano, Maggiolini, Stefano, Bonaffini, Pietro Andrea, Iacovoni, Attilio, Sironi, Sandro, Senni, Michele, Fominskiy, Evgeny, De Cobelli, Francesco, Maggioni, Aldo Pietro, Rapezzi, Claudio, Ferrari, Roberto, Colombo, Antonio, Esposito, Antonio, Giannini, F, Toselli, M, Palmisano, A, Cereda, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Manfrini, M, Khokhar, A, Sticchi, A, Biagi, A, Turchio, P, Tacchetti, C, Landoni, G, Boccia, E, Campo, G, Scoccia, A, Ponticelli, F, Danzi, G, Loffi, M, Muri, M, Pontone, G, Andreini, D, Mancini, E, Casella, G, Iannopollo, G, Nannini, T, Ippolito, D, Bellani, G, Franzesi, C, Patelli, G, Besana, F, Costa, C, Vignali, L, Benatti, G, Sverzellati, N, Scarnecchia, E, Lombardo, F, Anastasio, F, Iannaccone, M, Vaudano, P, Pacielli, A, Baffoni, L, Gardi, I, Cesini, E, Sperandio, M, Micossi, C, De Carlini, C, Spreafico, C, Maggiolini, S, Bonaffini, P, Iacovoni, A, Sironi, S, Senni, M, Fominskiy, E, De Cobelli, F, Maggioni, A, Rapezzi, C, Ferrari, R, Colombo, A, Esposito, A, Giannini, Francesco, Toselli, Marco, Palmisano, Anna, Cereda, Alberto, Vignale, Davide, Leone, Riccardo, Nicoletti, Valeria, Gnasso, Chiara, Monello, Alberto, Manfrini, Marco, Khokhar, Arif, Sticchi, Alessandro, Biagi, Andrea, Turchio, Piergiorgio, Tacchetti, Carlo, Landoni, Giovanni, Boccia, Edda, Campo, Gianluca, Scoccia, Alessandra, Ponticelli, Francesco, Danzi, Gian Battista, Loffi, Marco, Muri, Margherita, Pontone, Gianluca, Andreini, Daniele, Mancini, Elisabetta Maria, Casella, Gianni, Iannopollo, Gianmarco, Nannini, Tommaso, Ippolito, Davide, Bellani, Giacomo, Franzesi, Camillo Talei, Patelli, Gianluigi, Besana, Francesca, Costa, Claudia, Vignali, Luigi, Benatti, Giorgio, Sverzellati, Nicola, Scarnecchia, Elisa, Lombardo, Francesco Paolo, Anastasio, Fabio, Iannaccone, Mario, Vaudano, Paolo Giacomo, Pacielli, Alberto, Baffoni, Lucio, Gardi, Iljia, Cesini, Elisabetta, Sperandio, Massimiliano, Micossi, Chiara, De Carlini, Caterina Chiara, Spreafico, Cristiano, Maggiolini, Stefano, Bonaffini, Pietro Andrea, Iacovoni, Attilio, Sironi, Sandro, Senni, Michele, Fominskiy, Evgeny, De Cobelli, Francesco, Maggioni, Aldo Pietro, Rapezzi, Claudio, Ferrari, Roberto, Colombo, Antonio, and Esposito, Antonio
- Abstract
Background: Coronavirus disease 2019 (COVID-19) has spread worldwide determining dramatic impacts on healthcare systems. Early identification of high-risk parameters is required in order to provide the best therapeutic approach. Coronary, thoracic aorta and aortic valve calcium can be measured from a non-gated chest computer tomography (CT) and are validated predictors of cardiovascular events and all-cause mortality. However, their prognostic role in acute systemic inflammatory diseases, such as COVID-19, has not been investigated. Objectives: The aim was to evaluate the association of coronary artery calcium and total thoracic calcium on in-hospital mortality in COVID-19 patients. Methods: 1093 consecutive patients from 16 Italian hospitals with a positive swab for COVID-19 and an admission chest CT for pneumonia severity assessment were included. At CT, coronary, aortic valve and thoracic aorta calcium were qualitatively and quantitatively evaluated separately and combined together (total thoracic calcium) by a central Core-lab blinded to patients’ outcomes. Results: Non-survivors compared to survivors had higher coronary artery [Agatston (467.76 ± 570.92 vs 206.80 ± 424.13 mm2, p < 0.001); Volume (487.79 ± 565.34 vs 207.77 ± 406.81, p < 0.001)], aortic valve [Volume (322.45 ± 390.90 vs 98.27 ± 250.74 mm2, p < 0.001; Agatston 337.38 ± 414.97 vs 111.70 ± 282.15, p < 0.001)] and thoracic aorta [Volume (3786.71 ± 4225.57 vs 1487.63 ± 2973.19 mm2, p < 0.001); Agatston (4688.82 ± 5363.72 vs 1834.90 ± 3761.25, p < 0.001)] calcium values. Coronary artery calcium (HR 1.308; 95% CI, 1.046–1.637, p = 0.019) and total thoracic calcium (HR 1.975; 95% CI, 1.200–3.251, p = 0.007) resulted to be independent predictors of in-hospital mortality. Conclusion: Coronary, aortic valve and thoracic aortic calcium assessment on admission non-gated CT permits to stratify the COVID-19 patients in-hospital mortality risk.
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- 2021
12. Chest CT-derived pulmonary artery enlargement at the admission predicts overall survival in COVID-19 patients: insight from 1461 consecutive patients in Italy
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Esposito, A, Palmisano, A, Toselli, M, Vignale, D, Cereda, A, Rancoita, P, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Biagi, A, Turchio, P, Landoni, G, Gallone, G, Monti, G, Casella, G, Iannopollo, G, Nannini, T, Patelli, G, Di Mare, L, Loffi, M, Sergio, P, Ippolito, D, Sironi, S, Pontone, G, Andreini, D, Mancini, E, Di Serio, C, De Cobelli, F, Ciceri, F, Zangrillo, A, Colombo, A, Tacchetti, C, Giannini, F, Esposito, Antonio, Palmisano, Anna, Toselli, Marco, Vignale, Davide, Cereda, Alberto, Rancoita, Paola Maria Vittoria, Leone, Riccardo, Nicoletti, Valeria, Gnasso, Chiara, Monello, Alberto, Biagi, Andrea, Turchio, Piergiorgio, Landoni, Giovanni, Gallone, Guglielmo, Monti, Giacomo, Casella, Gianni, Iannopollo, Gianmarco, Nannini, Tommaso, Patelli, Gianluigi, Di Mare, Luisa, Loffi, Marco, Sergio, Pietro, Ippolito, Davide, Sironi, Sandro, Pontone, Gianluca, Andreini, Daniele, Mancini, Elisabetta Maria, Di Serio, Clelia, De Cobelli, Francesco, Ciceri, Fabio, Zangrillo, Alberto, Colombo, Antonio, Tacchetti, Carlo, Giannini, Francesco, Esposito, A, Palmisano, A, Toselli, M, Vignale, D, Cereda, A, Rancoita, P, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Biagi, A, Turchio, P, Landoni, G, Gallone, G, Monti, G, Casella, G, Iannopollo, G, Nannini, T, Patelli, G, Di Mare, L, Loffi, M, Sergio, P, Ippolito, D, Sironi, S, Pontone, G, Andreini, D, Mancini, E, Di Serio, C, De Cobelli, F, Ciceri, F, Zangrillo, A, Colombo, A, Tacchetti, C, Giannini, F, Esposito, Antonio, Palmisano, Anna, Toselli, Marco, Vignale, Davide, Cereda, Alberto, Rancoita, Paola Maria Vittoria, Leone, Riccardo, Nicoletti, Valeria, Gnasso, Chiara, Monello, Alberto, Biagi, Andrea, Turchio, Piergiorgio, Landoni, Giovanni, Gallone, Guglielmo, Monti, Giacomo, Casella, Gianni, Iannopollo, Gianmarco, Nannini, Tommaso, Patelli, Gianluigi, Di Mare, Luisa, Loffi, Marco, Sergio, Pietro, Ippolito, Davide, Sironi, Sandro, Pontone, Gianluca, Andreini, Daniele, Mancini, Elisabetta Maria, Di Serio, Clelia, De Cobelli, Francesco, Ciceri, Fabio, Zangrillo, Alberto, Colombo, Antonio, Tacchetti, Carlo, and Giannini, Francesco
- Abstract
Objectives Enlarged main pulmonary artery diameter (MPAD) resulted to be associated with pulmonary hypertension and mortality in a non-COVID-19 setting. The aim was to investigate and validate the association between MPAD enlargement and overall survival in COVID-19 patients. Methods This is a cohort study on 1469 consecutive COVID-19 patients submitted to chest CT within 72 h from admission in seven tertiary level hospitals in Northern Italy, between March 1 and April 20, 2020. Derivation cohort (n = 761) included patients from the first three participating hospitals; validation cohort (n = 633) included patients from the remaining hospitals. CT images were centrally analyzed in a core-lab blinded to clinical data. The prognostic value of MPAD on overall survival was evaluated at adjusted and multivariable Cox's regression analysis on the derivation cohort. The final multivariable model was tested on the validation cohort. Results In the derivation cohort, the median age was 69 (IQR, 58-77) years and 537 (70.6%) were males. In the validation cohort, the median age was 69 (IQR, 59-77) years with 421 (66.5%) males. Enlarged MPAD (>= 31 mm) was a predictor of mortality at adjusted (hazard ratio, HR [95%CI]: 1.741 [1.253-2.418], p < 0.001) and multivariable regression analysis (HR [95%CI]: 1.592 [1.154-2.196], p = 0.005), together with male gender, old age, high creatinine, low well-aerated lung volume, and high pneumonia extension (c-index [95%CI] = 0.826 [0.796-0.851]). Model discrimination was confirmed on the validation cohort (c-index [95%CI] = 0.789 [0.758-0.823]), also using CT measurements from a second reader (c-index [95%CI] = 0.790 [0.753;0.825]). Conclusion Enlarged MPAD (>= 31 mm) at admitting chest CT is an independent predictor of mortality in COVID-19.
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- 2021
13. Chest CT in the emergency department for suspected COVID-19 pneumonia
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Palmisano, A, Scotti, G, Ippolito, D, Morelli, M, Vignale, D, Gandola, D, Sironi, S, De Cobelli, F, Ferrante, L, Spessot, M, Tonon, G, Tacchetti, C, Esposito, A, Palmisano, Anna, Scotti, Giulia Maria, Ippolito, Davide, Morelli, Marco J, Vignale, Davide, Gandola, Davide, Sironi, Sandro, De Cobelli, Francesco, Ferrante, Luca, Spessot, Marzia, Tonon, Giovanni, Tacchetti, Carlo, Esposito, Antonio, Palmisano, A, Scotti, G, Ippolito, D, Morelli, M, Vignale, D, Gandola, D, Sironi, S, De Cobelli, F, Ferrante, L, Spessot, M, Tonon, G, Tacchetti, C, Esposito, A, Palmisano, Anna, Scotti, Giulia Maria, Ippolito, Davide, Morelli, Marco J, Vignale, Davide, Gandola, Davide, Sironi, Sandro, De Cobelli, Francesco, Ferrante, Luca, Spessot, Marzia, Tonon, Giovanni, Tacchetti, Carlo, and Esposito, Antonio
- Abstract
Purpose: In overwhelmed emergency departments (EDs) facing COVID-19 outbreak, a swift diagnosis is imperative. CT role was widely debated for its limited specificity. Here we report the diagnostic role of CT in two EDs in Lombardy, epicenter of Italian outbreak. Material and methods: Admitting chest CT from 142 consecutive patients with suspected COVID-19 were retrospectively analyzed. CT scans were classified in "highly likely," "likely," and "unlikely" COVID-19 pneumonia according to the presence of typical, indeterminate, and atypical findings, or "negative" in the absence of findings, or "alternative diagnosis" when a different diagnosis was found. Nasopharyngeal swab results, turnaround time, and time to positive results were collected. CT diagnostic performances were assessed considering RT-PCR as reference standard. Results: Most of cases (96/142, 68%) were classified as "highly likely" COVID-19 pneumonia. Ten (7%) and seven (5%) patients were classified as "likely" and "unlikely" COVID-19 pneumonia, respectively. In 21 (15%) patients a differential diagnosis was provided, including typical pneumonia, pulmonary edema, neoplasia, and pulmonary embolism. CT was negative in 8/142 (6%) patients. Mean turnaround time for the first COVID-19 RT-PCR was 30 ± 13 h. CT diagnostic accuracy in respect of the first test swab was 79% and increased to 91.5% after repeated swabs and/or BAL, for 18 false-negative first swab. CT performance was good with 76% specificity, 99% sensitivity, 90% positive predictive value and 97% negative predictive value. Conclusion: Chest CT was useful to streamline patients' triage while waiting for RT-PCR in the ED, supporting the clinical suspicion of COVID-19 or providing alternative diagnosis.
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- 2021
14. Cardiac Magnetic Resonance Characterization of Myocarditis-Like Acute Cardiac Syndrome in COVID-19
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Esposito, A., Palmisano, A., Natale, Luigi, Ligabue, G., Peretto, G., Lovato, L., Vignale, D., Fiocchi, F., Marano, Riccardo, Russo, V., Natale L. (ORCID:0000-0002-7949-5119), Marano R. (ORCID:0000-0003-2710-2093), Esposito, A., Palmisano, A., Natale, Luigi, Ligabue, G., Peretto, G., Lovato, L., Vignale, D., Fiocchi, F., Marano, Riccardo, Russo, V., Natale L. (ORCID:0000-0002-7949-5119), and Marano R. (ORCID:0000-0003-2710-2093)
- Abstract
Novel coronavirus infection causes a systemic disease (coronavirus disease-2019 [COVID-19]) with, most frequently, respiratory involvement. In addition to systemic and respiratory complications, COVID-19 can reveal itself as a myocarditis-like syndrome (AMCovS), whose underlying mechanism is largely unknown. A limited number of case reports have described cardiac magnetic resonance (CMR) findings in AMCovS; only 2 of which included mapping.
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- 2020
15. Severe acute respiratory syndrome coronavirus-2-induced flare of systemic sclerosis.
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Campochiaro, C, De Luca, G, Farina, N, Vignale, D, Palmisano, A, Matucci-Cerinic, M, and Dagna, L
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SYSTEMIC scleroderma ,CORONAVIRUS diseases ,SARS-CoV-2 ,MEDICAL personnel - Abstract
To the best of our knowledge, this is the first report of SSc progression following a repeated SARS-CoV-2 infection, and offers important insights for both SARS-CoV-2 and SSc. Systemic sclerosis (SSc) patients may develop severe coronavirus disease 2019 (COVID-19) ([1]), but no reports are available on disease progression following a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. It is notable that the disease progression occurred in a patient with long-standing, stable, limited cutaneous SSc disease, and that the severity of the flare was not proportional to the mild clinical course of COVID-19. [Extracted from the article]
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- 2022
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16. Coronary and total thoracic calcium scores predict mortality and provides pathophysiologic insights in COVID-19 patients
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Giovanni Landoni, Andrea Biagi, Nicola Sverzellati, Roberto Ferrari, Fabio Anastasio, Gianluigi Patelli, Claudia Costa, Piergiorgio Turchio, Arif A. Khokhar, Alessandra Scoccia, Pietro Andrea Bonaffini, Cristiano Spreafico, Camillo Talei Franzesi, Gianni Casella, Edda Boccia, Antonio Esposito, Marco Toselli, Aldo P. Maggioni, Elisabetta Mancini, Chiara Gnasso, Luigi Vignali, Alessandro Sticchi, Elisa Scarnecchia, Antonio Colombo, Giacomo Bellani, Gianluca Pontone, Alberto Cereda, Caterina Chiara De Carlini, Marco Manfrini, Francesco Ponticelli, Stefano Maggiolini, Anna Palmisano, Claudio Rapezzi, Marco Loffi, Alberto Pacielli, Francesca Besana, Michele Senni, Lucio Baffoni, Sandro Sironi, Evgeny Fominskiy, Gianmarco Iannopollo, Francesco De Cobelli, Daniele Andreini, Giorgio Benatti, Paolo Giacomo Vaudano, Francesco Giannini, Gian Battista Danzi, Chiara Micossi, Alberto Monello, Tommaso Nannini, Massimiliano Sperandio, Carlo Tacchetti, Mario Iannaccone, Davide Vignale, Attilio Iacovoni, Riccardo Leone, Davide Ippolito, Gianluca Campo, Francesco Paolo Lombardo, Elisabetta Cesini, Valeria Nicoletti, Margherita Muri, Iljia Gardi, Giannini, F., Toselli, M., Palmisano, A., Cereda, A., Vignale, D., Leone, R., Nicoletti, V., Gnasso, C., Monello, A., Manfrini, M., Khokhar, A., Sticchi, A., Biagi, A., Turchio, P., Tacchetti, C., Landoni, G., Boccia, E., Campo, G., Scoccia, A., Ponticelli, F., Danzi, G. B., Loffi, M., Muri, M., Pontone, G., Andreini, D., Mancini, E. M., Casella, G., Iannopollo, G., Nannini, T., Ippolito, D., Bellani, G., Franzesi, C. T., Patelli, G., Besana, F., Costa, C., Vignali, L., Benatti, G., Sverzellati, N., Scarnecchia, E., Lombardo, F. P., Anastasio, F., Iannaccone, M., Vaudano, P. G., Pacielli, A., Baffoni, L., Gardi, I., Cesini, E., Sperandio, M., Micossi, C., De Carlini, C. C., Spreafico, C., Maggiolini, S., Bonaffini, P. A., Iacovoni, A., Sironi, S., Senni, M., Fominskiy, E., De Cobelli, F., Maggioni, A. P., Rapezzi, C., Ferrari, R., Colombo, A., Esposito, A., Giannini, F, Toselli, M, Palmisano, A, Cereda, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Manfrini, M, Khokhar, A, Sticchi, A, Biagi, A, Turchio, P, Tacchetti, C, Landoni, G, Boccia, E, Campo, G, Scoccia, A, Ponticelli, F, Danzi, G, Loffi, M, Muri, M, Pontone, G, Andreini, D, Mancini, E, Casella, G, Iannopollo, G, Nannini, T, Ippolito, D, Bellani, G, Franzesi, C, Patelli, G, Besana, F, Costa, C, Vignali, L, Benatti, G, Sverzellati, N, Scarnecchia, E, Lombardo, F, Anastasio, F, Iannaccone, M, Vaudano, P, Pacielli, A, Baffoni, L, Gardi, I, Cesini, E, Sperandio, M, Micossi, C, De Carlini, C, Spreafico, C, Maggiolini, S, Bonaffini, P, Iacovoni, A, Sironi, S, Senni, M, Fominskiy, E, De Cobelli, F, Maggioni, A, Rapezzi, C, Ferrari, R, Colombo, A, and Esposito, A
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Aortic valve ,Male ,Computed Tomography Angiography ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,Severity of Illness Index ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Thoracic aorta ,Aged, 80 and over ,Middle Aged ,Coronary Vessels ,Pathophysiology ,Calcium score ,In-hospital mortality ,medicine.anatomical_structure ,Italy ,Aortic Valve ,Cardiology ,Aortic valve, Calcification, Calcium score, Coronary artery, COVID-19, Thoracic aorta, In-hospital mortality ,Female ,Cardiology and Cardiovascular Medicine ,Artery ,Research Paper ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Pneumonia, Viral ,Aortic Diseases ,chemistry.chemical_element ,Calcium ,Coronary artery ,NO ,Calcification ,03 medical and health sciences ,Predictive Value of Tests ,medicine.artery ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Vascular Calcification ,Aged ,Retrospective Studies ,business.industry ,SARS-CoV-2 ,COVID-19 ,medicine.disease ,Pneumonia ,chemistry ,business - Abstract
BACKGROUND: Coronavirus disease 2019 (COVID-19) has spread worldwide determining dramatic impacts on healthcare systems. Early identification of high-risk parameters is required in order to provide the best therapeutic approach. Coronary, thoracic aorta and aortic valve calcium can be measured from a non-gated chest computer tomography (CT) and are validated predictors of cardiovascular events and all-cause mortality. However, their prognostic role in acute systemic inflammatory diseases, such as COVID-19, has not been investigated. OBJECTIVES: The aim was to evaluate the association of coronary artery calcium and total thoracic calcium on in-hospital mortality in COVID-19 patients. METHODS: 1093 consecutive patients from 16 Italian hospitals with a positive swab for COVID-19 and an admission chest CT for pneumonia severity assessment were included. At CT, coronary, aortic valve and thoracic aorta calcium were qualitatively and quantitatively evaluated separately and combined together (total thoracic calcium) by a central Core-lab blinded to patients' outcomes. RESULTS: Non-survivors compared to survivors had higher coronary artery [Agatston (467.76 â± â570.92 vs 206.80 â± â424.13 âmm2, p â
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- 2021
17. Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19
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Arif A. Khokhar, Alberto Pacielli, Francesco Ponticelli, Marco Toselli, Gianmarco Iannopollo, Alberto Monello, Davide Ippolito, Antonio Colombo, Alessandro Sticchi, Antonio Esposito, Anna Palmisano, Luigi Vignali, Gianluca Campo, Pietro Andrea Bonaffini, Valeria Nicoletti, Caterina Chiara De Carlini, Daniele Andreini, Claudia Costa, Riccardo Leone, Giorgio Benatti, Giacomo Bellani, Marco Loffi, Andrea Biagi, Carlo Tacchetti, Fabio Anastasio, Elisa Scarnecchia, Chiara Gnasso, Alessandra Scoccia, Stefano Maggiolini, Gian Battista Danzi, Roberto Ferrari, Francesca Besana, Gianluigi Patelli, Claudio Rapezzi, Mario Iannaccone, Davide Vignale, Michele Senni, Gianluca Pontone, Guglielmo Gallone, Francesco Giannini, Gianni Casella, Alberto Cereda, Paolo Giacomo Vaudano, Scoccia, A, Gallone, G, Cereda, A, Palmisano, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Khokhar, A, Sticchi, A, Biagi, A, Tacchetti, C, Campo, G, Rapezzi, C, Ponticelli, F, Danzi, G, Loffi, M, Pontone, G, Andreini, D, Casella, G, Iannopollo, G, Ippolito, D, Bellani, G, Patelli, G, Besana, F, Costa, C, Vignali, L, Benatti, G, Iannaccone, M, Vaudano, P, Pacielli, A, De Carlini, C, Maggiolini, S, Bonaffini, P, Senni, M, Scarnecchia, E, Anastasio, F, Colombo, A, Ferrari, R, Esposito, A, Giannini, F, Toselli, M, Scoccia, A., Gallone, G., Cereda, A., Palmisano, A., Vignale, D., Leone, R., Nicoletti, V., Gnasso, C., Monello, A., Khokhar, A., Sticchi, A., Biagi, A., Tacchetti, C., Campo, G., Rapezzi, C., Ponticelli, F., Danzi, G. B., Loffi, M., Pontone, G., Andreini, D., Casella, G., Iannopollo, G., Ippolito, D., Bellani, G., Patelli, G., Besana, F., Costa, C., Vignali, L., Benatti, G., Iannaccone, M., Vaudano, P. G., Pacielli, A., De Carlini, C. C., Maggiolini, S., Bonaffini, P. A., Senni, M., Scarnecchia, E., Anastasio, F., Colombo, A., Ferrari, R., Esposito, A., Giannini, F., and Toselli, M.
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0301 basic medicine ,Male ,medicine.medical_specialty ,coronary artery calcifications ,Coronary Artery Disease ,Coronary artery calcification ,030204 cardiovascular system & hematology ,Coronary Angiography ,Agatston score ,Coronary artery disease ,Article ,NO ,COVID-19, Coronary artery disease, Atherosclerosis, Agatston score, Coronary artery calcifications, Calcium score, In-hospital mortality ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Risk Factors ,Internal medicine ,Coronary artery calcifications ,Clinical endpoint ,Medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Coronary atherosclerosis ,Subclinical infection ,Aged ,Retrospective Studies ,business.industry ,SARS-CoV-2 ,Hazard ratio ,COVID-19 ,Middle Aged ,medicine.disease ,Atherosclerosis ,Coronary Vessels ,Calcium score ,In-hospital mortality ,030104 developmental biology ,Atherosclerosi ,Cardiology ,Calcium ,atherosclerosis ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background and aims The potential impact of coronary atherosclerosis, as detected by coronary artery calcium, on clinical outcomes in COVID-19 patients remains unsettled. We aimed to evaluate the prognostic impact of clinical and subclinical coronary artery disease (CAD), as assessed by coronary artery calcium score (CAC), in a large, unselected population of hospitalized COVID-19 patients undergoing non-gated chest computed tomography (CT) for clinical practice. Methods SARS-CoV 2 positive patients from the multicenter (16 Italian hospitals), retrospective observational SCORE COVID-19 (calcium score for COVID-19 Risk Evaluation) registry were stratified in three groups: (a) “clinical CAD” (prior revascularization history), (b) “subclinical CAD” (CAC >0), (c) “No CAD” (CAC=0). Primary endpoint was in-hospital mortality and the secondary endpoint was a composite of myocardial infarction and cerebrovascular accident (MI/CVA). Results Amongst 1625 patients (male 67.2%, median age 69 [interquartile range 58-77] years), 31%, 57.8% and 11.1% had no, subclinical and clinical CAD, respectively. Increasing rates of in-hospital mortality (11.3% vs. 27.3% vs. 39.8%, p400, respectively, p, Graphical abstract Image 1
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- 2021
18. Chest CT in the emergency department for suspected COVID-19 pneumonia
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Giovanni Tonon, Marzia Spessot, Giulia Maria Scotti, Sandro Sironi, Marco Jacopo Morelli, Davide Vignale, Carlo Tacchetti, Davide Ippolito, Davide Gandola, Antonio Esposito, Anna Palmisano, Luca Ferrante, Francesco De Cobelli, Palmisano, A., Scotti, G. M., Ippolito, D., Morelli, M. J., Vignale, D., Gandola, D., Sironi, S., De Cobelli, F., Ferrante, L., Spessot, M., Tonon, G., Tacchetti, C., Esposito, A., Palmisano, A, Scotti, G, Ippolito, D, Morelli, M, Vignale, D, Gandola, D, Sironi, S, De Cobelli, F, Ferrante, L, Spessot, M, Tonon, G, Tacchetti, C, and Esposito, A
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Male ,medicine.medical_specialty ,Short Communication ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Diagnosis ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Lung ,Computed tomography ,Neuroradiology ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,COVID-19 ,Interventional radiology ,Emergency department ,General Medicine ,Middle Aged ,medicine.disease ,Pulmonary edema ,Triage ,Pulmonary embolism ,Pneumonia ,Italy ,Radiology Nuclear Medicine and imaging ,030220 oncology & carcinogenesis ,Emergency ,Female ,Radiology ,Differential diagnosis ,business ,Emergency Service, Hospital ,Tomography, X-Ray Computed ,Diagnosi - Abstract
Purpose: In overwhelmed emergency departments (EDs) facing COVID-19 outbreak, a swift diagnosis is imperative. CT role was widely debated for its limited specificity. Here we report the diagnostic role of CT in two EDs in Lombardy, epicenter of Italian outbreak. Material and methods: Admitting chest CT from 142 consecutive patients with suspected COVID-19 were retrospectively analyzed. CT scans were classified in “highly likely,” “likely,” and “unlikely” COVID-19 pneumonia according to the presence of typical, indeterminate, and atypical findings, or “negative” in the absence of findings, or “alternative diagnosis” when a different diagnosis was found. Nasopharyngeal swab results, turnaround time, and time to positive results were collected. CT diagnostic performances were assessed considering RT-PCR as reference standard. Results: Most of cases (96/142, 68%) were classified as “highly likely” COVID-19 pneumonia. Ten (7%) and seven (5%) patients were classified as “likely” and “unlikely” COVID-19 pneumonia, respectively. In 21 (15%) patients a differential diagnosis was provided, including typical pneumonia, pulmonary edema, neoplasia, and pulmonary embolism. CT was negative in 8/142 (6%) patients. Mean turnaround time for the first COVID-19 RT-PCR was 30 ± 13h. CT diagnostic accuracy in respect of the first test swab was 79% and increased to 91.5% after repeated swabs and/or BAL, for 18 false-negative first swab. CT performance was good with 76% specificity, 99% sensitivity, 90% positive predictive value and 97% negative predictive value. Conclusion: Chest CT was useful to streamline patients’ triage while waiting for RT-PCR in the ED, supporting the clinical suspicion of COVID-19 or providing alternative diagnosis.
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- 2020
19. SIRM–SIC appropriateness criteria for the use of Cardiac Computed Tomography. Part 1: Congenital heart diseases, primary prevention, risk assessment before surgery, suspected CAD in symptomatic patients, plaque and epicardial adipose tissue characterization, and functional assessment of stenosis
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Andrea Igoren Guaricci, Alberto Clemente, Vitaliano Buffa, Roberto Sciagrà, Saima Mushtaq, Iacopo Carbone, Marco Guglielmo, Guido Ligabue, Marco Francone, Danilo Neglia, Sara Seitun, Antonio Esposito, Gianluca Pontone, Nazario Carrabba, Anna Palmisano, Filippo Cademartiri, Carlo Liguori, Daniele Andreini, Ludovico La Grutta, Ciro Indolfi, Giuseppe Mercuro, Davide Vignale, Esposito A., Francone M., Andreini D., Buffa V., Cademartiri F., Carbone I., Clemente A., Guaricci A.I., Guglielmo M., Indolfi C., La Grutta L., Ligabue G., Liguori C., Mercuro G., Mushtaq S., Neglia D., Palmisano A., Sciagra R., Seitun S., Vignale D., Pontone G., and Carrabba N.
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genetic structures ,Cardiac computed tomography ,Computed Tomography Angiography ,Coronary Disease ,CAD ,030204 cardiovascular system & hematology ,Chest pain ,Chest pain, Congenital heart disease, Coronary CT angiography, Epicardial adipose tissue, Plaque, Stenosis ,law.invention ,Congenital ,0302 clinical medicine ,Randomized controlled trial ,law ,030212 general & internal medicine ,Heart Defects ,Plaque ,Neuroradiology ,Stenosis ,medicine.diagnostic_test ,Calcinosis ,Heart ,Interventional radiology ,General Medicine ,Fractional Flow Reserve ,Fractional Flow Reserve, Myocardial ,Primary Prevention ,Position Paper ,Congenital heart disease ,Coronary CT angiography ,Epicardial adipose tissue ,Coronary Stenosis ,Heart Defects, Congenital ,Humans ,Cardiac Imaging Techniques ,Preoperative Care ,medicine.symptom ,Risk assessment ,medicine.medical_specialty ,03 medical and health sciences ,medicine ,Myocardial ,Radiology, Nuclear Medicine and imaging ,Intensive care medicine ,business.industry ,medicine.disease ,business - Abstract
In the past 20 years, Cardiac Computed Tomography (CCT) has become a pivotal technique for the noninvasive diagnostic work-up of coronary and cardiac diseases. Continuous technical and methodological improvements, combined with fast growing scientific evidence, have progressively expanded the clinical role of CCT. Recent large multicenter randomized clinical trials documented the high prognostic value of CCT and its capability to increase the cost-effectiveness of the management of patients with suspected CAD. In the meantime, CCT, initially perceived as a simple non-invasive technique for studying coronary anatomy, has transformed into a multiparametric “one-stop-shop” approach able to investigate the heart in a comprehensive way, including functional, structural and pathophysiological biomarkers. In this complex and revolutionary scenario, it is urgently needed to provide an updated guide for the appropriate use of CCT in different clinical settings. This manuscript, endorsed by the Italian Society of Medical and Interventional Radiology (SIRM) and by the Italian Society of Cardiology (SIC), represents the first of two consensus documents collecting the expert opinion of Radiologists and Cardiologists about current appropriate use of CCT.
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- 2021
20. Chest CT–derived pulmonary artery enlargement at the admission predicts overall survival in COVID-19 patients: insight from 1461 consecutive patients in Italy
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Alberto Monello, Gianluigi Patelli, Tommaso Nannini, Gianmarco Iannopollo, Antonio Esposito, Francesco De Cobelli, Anna Palmisano, Piergiorgio Turchio, Giovanni Landoni, Chiara Gnasso, Gianluca Pontone, Luisa Di Mare, Carlo Tacchetti, Clelia Di Serio, Antonio Colombo, Sandro Sironi, Marco Loffi, Fabio Ciceri, Andrea Biagi, Elisabetta Mancini, Daniele Andreini, Riccardo Leone, Pietro Sergio, Alberto Zangrillo, Giacomo Monti, Gianni Casella, Paola M.V. Rancoita, Alberto Cereda, Davide Vignale, Guglielmo Gallone, Francesco Giannini, Valeria Nicoletti, Davide Ippolito, Marco Toselli, Esposito, A, Palmisano, A, Toselli, M, Vignale, D, Cereda, A, Rancoita, P, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Biagi, A, Turchio, P, Landoni, G, Gallone, G, Monti, G, Casella, G, Iannopollo, G, Nannini, T, Patelli, G, Di Mare, L, Loffi, M, Sergio, P, Ippolito, D, Sironi, S, Pontone, G, Andreini, D, Mancini, E, Di Serio, C, De Cobelli, F, Ciceri, F, Zangrillo, A, Colombo, A, Tacchetti, C, Giannini, F, Esposito, Antonio, Palmisano, Anna, Toselli, Marco, Vignale, Davide, Cereda, Alberto, Rancoita, Paola Maria Vittoria, Leone, Riccardo, Nicoletti, Valeria, Gnasso, Chiara, Monello, Alberto, Biagi, Andrea, Turchio, Piergiorgio, Landoni, Giovanni, Gallone, Guglielmo, Monti, Giacomo, Casella, Gianni, Iannopollo, Gianmarco, Nannini, Tommaso, Patelli, Gianluigi, Di Mare, Luisa, Loffi, Marco, Sergio, Pietro, Ippolito, Davide, Sironi, Sandro, Pontone, Gianluca, Andreini, Daniele, Mancini, Elisabetta Maria, Di Serio, Clelia, De Cobelli, Francesco, Ciceri, Fabio, Zangrillo, Alberto, Colombo, Antonio, Tacchetti, Carlo, and Giannini, Francesco
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Male ,Thorax ,medicine.medical_specialty ,030204 cardiovascular system & hematology ,030218 nuclear medicine & medical imaging ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine.artery ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Lung volumes ,Aged ,Retrospective Studies ,medicine.diagnostic_test ,SARS-CoV-2 ,business.industry ,Tomography, X-ray computed ,Hazard ratio ,COVID-19 ,Interventional radiology ,General Medicine ,medicine.disease ,Pulmonary hypertension ,Pulmonary artery ,Pneumonia ,Italy ,Hypertension, pulmonary ,Radiology Nuclear Medicine and imaging ,Chest ,Female ,Radiology ,business ,Cohort study - Abstract
Objectives Enlarged main pulmonary artery diameter (MPAD) resulted to be associated with pulmonary hypertension and mortality in a non-COVID-19 setting. The aim was to investigate and validate the association between MPAD enlargement and overall survival in COVID-19 patients. Methods This is a cohort study on 1469 consecutive COVID-19 patients submitted to chest CT within 72 h from admission in seven tertiary level hospitals in Northern Italy, between March 1 and April 20, 2020. Derivation cohort (n = 761) included patients from the first three participating hospitals; validation cohort (n = 633) included patients from the remaining hospitals. CT images were centrally analyzed in a core-lab blinded to clinical data. The prognostic value of MPAD on overall survival was evaluated at adjusted and multivariable Cox’s regression analysis on the derivation cohort. The final multivariable model was tested on the validation cohort. Results In the derivation cohort, the median age was 69 (IQR, 58–77) years and 537 (70.6%) were males. In the validation cohort, the median age was 69 (IQR, 59–77) years with 421 (66.5%) males. Enlarged MPAD (≥ 31 mm) was a predictor of mortality at adjusted (hazard ratio, HR [95%CI]: 1.741 [1.253–2.418], p p = 0.005), together with male gender, old age, high creatinine, low well-aerated lung volume, and high pneumonia extension (c-index [95%CI] = 0.826 [0.796–0.851]). Model discrimination was confirmed on the validation cohort (c-index [95%CI] = 0.789 [0.758–0.823]), also using CT measurements from a second reader (c-index [95%CI] = 0.790 [0.753;0.825]). Conclusion Enlarged MPAD (≥ 31 mm) at admitting chest CT is an independent predictor of mortality in COVID-19. Key Points •Enlargement of main pulmonary artery diameter at chest CT performed within 72 h from the admission was associated with a higher rate of in-hospital mortality in COVID-19 patients. •Enlargement of main pulmonary artery diameter (≥ 31 mm) was an independent predictor of death in COVID-19 patients at adjusted and multivariable regression analysis. •The combined evaluation of clinical findings, lung CT features, and main pulmonary artery diameter may be useful for risk stratification in COVID-19 patients.
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- 2020
21. A numerical investigation to evaluate the washout of blood compartments in a total artificial heart
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Francesco De Gaetano, Francesco Migliavacca, Giulia Luraghi, Antonio Esposito, Nicolas Griffaton, Maria Laura Costantino, Gabriele Dubini, Jose Felix Rodriguez Matas, Hector De Castilla, Anna Palmisano, Giuseppe Gentile, Davide Vignale, Luraghi, G., De Gaetano, F., Rodriguez Matas, J. F., Dubini, G., Costantino, M. L., De Castilla, H., Griffaton, N., Vignale, D., Palmisano, A., Gentile, G., Esposito, A., and Migliavacca, F.
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Materials science ,medicine.medical_treatment ,test bench ,Biomedical Engineering ,Pulsatile flow ,fluid-structure interaction ,Medicine (miscellaneous) ,Bioengineering ,computational fluid dynamics ,Heart, Artificial ,Prosthesis Design ,law.invention ,Biomaterials ,law ,Artificial heart ,Fluid–structure interaction ,medicine ,Humans ,Computer Simulation ,Heart transplantation ,Models, Cardiovascular ,Washout ,washout evaluation ,Stroke Volume ,General Medicine ,Stroke volume ,total artificial heart ,medicine.anatomical_structure ,Volume (thermodynamics) ,Regional Blood Flow ,Ventricle ,Biomedical engineering - Abstract
Total artificial heart (TAH) represents the only valid alternative to heart transplantation, whose number is continuously increasing in recent years. The TAHused in this work, is a biventricular pulsatile, electrically powered, hydraulically actuated flow pump with all components embodied in a single device. One of the major issues for TAHs is the washout capability of the device, strictly correlated with the presence of blood stagnation sites. The aim of this work was to develop a numerical methodology to study the washout coupled with the fluid dynamics evaluation ofa total artificial heart under nominal working conditions. The first part of this study focussed on the CT scan analysis of the hybrid membrane kinematics during TAH operation, which was replicated with a fluid-structure interaction simulation in the second part. The difference in percentage between the in vitro and in silico flow rates and stroke volume is 9.7% and 6.3%, respectively. An injection of contrast blood was simulated, and a goodwashout performancewas observed and quantified with the volume fraction of the contrast blood still in the ventricle. The left chamber of the device showed a superior washout performance, with a contrast volume still inside the device after four washout cycles of 6.2%, with the right chamber showing 15%.
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- 2020
22. Late iodine enhancement cardiac computed tomography for detection of myocardial scars: impact of experience in the clinical practice
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Giulia Benedetti, Davide Vignale, Anna Palmisano, Antonio Esposito, Alessandro Del Maschio, Francesco De Cobelli, Palmisano, A., Vignale, D., Benedetti, G., Del Maschio, A., De Cobelli, F., and Esposito, A.
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Male ,medicine.medical_specialty ,Cardiac computed tomography ,Iohexol ,Cardiac-Gated Imaging Techniques ,Contrast Media ,Scars ,Cardiac-Gated Imaging Technique ,Sensitivity and Specificity ,Late iodine enhancement ,030218 nuclear medicine & medical imaging ,Cicatrix ,03 medical and health sciences ,0302 clinical medicine ,Scar ,Organometallic Compounds ,medicine ,Humans ,Late gadolinium enhancement ,Radiology, Nuclear Medicine and imaging ,Computed tomography ,Neuroradiology ,Organometallic Compound ,medicine.diagnostic_test ,business.industry ,Myocardium ,Ultrasound ,Interventional radiology ,General Medicine ,Middle Aged ,Magnetic Resonance Imaging ,Clinical Practice ,030220 oncology & carcinogenesis ,Etiology ,Female ,Radiology ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Human - Abstract
Background: Cardiac CT with late iodine enhancement (LIE-CT) may characterize the scarred myocardium, but the role of readers’ experience and scar pattern on LIE-CT diagnostic performance is unknown. Aim was to assess the diagnostic performance of LIE-CT according to readers’ experience, scar pattern and contrast-to-noise ratio (CNR) using late gadolinium enhancement MRI (LGE-MRI) as reference. Methods: LIE-CT and LGE-MRI images of 40 consecutive patients were analyzed. Two readers with different experience (8 and 2years) independently analyzed LIE-CT images defining the presence/absence of scar and scar CNR, segmental involvement, transmural pattern and scar etiology. The same parameters were extracted from LGE-MRI by two expert readers in consensus, blinded to the LIE-CT results. Results: Scars were identified at LGE-MRI in 29/40 patients and 141/680 segments. Scar burden at LIE-CT versus LGE-MRI correlated better for the most experienced reader than for the least experienced one (ρ = 0.954 and ρ = 0.797, p < 0.001). The most experienced reader missed scars in 2 patients and in 21/141 segments; the least experienced in 5 patients and 53/141 segments. The most experienced reader showed higher accuracy and sensitivity compared to the least experienced in per-patient (accuracy: 95% vs. 88%; sensitivity: 93% vs. 83%) and per-segment analysis (accuracy: 96% vs. 92%; sensitivity: 85% vs. 62%). Specificity was excellent (100% per-patient, 99% per-segment,) regardless of readers’ experience. Missed scars had non-ischemic pattern, low scar burden (< 6%) and lower CNR compared to ischemic scars (2.33 vs. 3.54, p = 0.005). Conclusion: LIE-CT represents an alternative to LGE-MRI, although the impact of readers’ experience on sensitivity for small non-ischemic scars should be considered.
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- 2019
23. The hidden interplay between sex and COVID-19 mortality: the role of cardiovascular calcification
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Matteo Bertini, Alberto Monello, Marco Toselli, Francesco Giannini, Mario Iannaccone, Davide Vignale, Alessandra Scoccia, Tommaso Nannini, Francesca Besana, Gianluca Campo, Luigi Vignali, Anna Palmisano, Antonio Esposito, Giuseppe Sangiorgi, Chiara Gnasso, Davide Ippolito, Daniele Andreini, Riccardo Leone, Pietro Sergio, Piergiorgio Turchio, Antonio Mangieri, Arif A Khokhar, Valeria Nicoletti, Gianluigi Patelli, Paolo Giacomo Vaudano, Antonio Colombo, Alberto Cereda, G Pontone, Claudio Rapezzi, Aldo P. Maggioni, Gianmarco Iannopollo, Nicola Sverzellati, Marco Loffi, Giacomo Bellani, Gabriele Tumminello, Cereda, A, Toselli, M, Palmisano, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Mangieri, A, Khokhar, A, Campo, G, Scoccia, A, Bertini, M, Loffi, M, Sergio, P, Andreini, D, Pontone, G, Iannopollo, G, Nannini, T, Ippolito, D, Bellani, G, Patelli, G, Besana, F, Vignali, L, Sverzellati, N, Iannaccone, M, Vaudano, P, Sangiorgi, G, Turchio, P, Monello, A, Tumminello, G, Maggioni, A, Rapezzi, C, Colombo, A, Giannini, F, and Esposito, A
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Cardiovascular calcifications ,Male ,Aging ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Context (language use) ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,Sex bia ,Sars-CoV2 ,NO ,Settore MED/11 ,03 medical and health sciences ,0302 clinical medicine ,Cardiovascular calcification ,Internal medicine ,medicine.artery ,Lung CT ,Medicine ,Thoracic aorta ,Humans ,030212 general & internal medicine ,Vascular Calcification ,Aged ,Aged, 80 and over ,Sex bias ,business.industry ,SARS-CoV-2 ,Mortality rate ,COVID-19 ,medicine.disease ,Sex bias, Sars-CoV2, Lung CT, Cardiovascular calcifcations, COVID-19 ,Coronary Calcium Score ,Pneumonia ,Coronary artery calcification ,RNA, Viral ,Cardiovascular calcifcations ,Female ,Original Article ,Geriatrics and Gerontology ,business - Abstract
Recent clinical and demographical studies on COVID-19 patients have demonstrated that men experience worse outcomes than women. However, in most cases, the data were not stratified according to gender, limiting the understanding of the real impact of gender on outcomes. This study aimed to evaluate the disaggregated in-hospital outcomes and explore the possible interactions between gender and cardiovascular calcifications. Data was derived from the sCORE-COVID-19 registry, an Italian multicentre registry that enrolled COVID-19 patients who had undergone a chest computer tomography scan on admission. A total of 1683 hospitalized patients (mean age 67±14 years) were included. Men had a higher prevalence of cardiovascular comorbidities, a higher pneumonia extension, more coronary calcifications (63% vs.50.9%, p3, pp=0.001), but the death event tended to occur earlier in women (15±7 vs. 8±7 days, p= 0.07). Non-survivors had a higher coronary, thoracic aorta, and aortic valve calcium score. Female sex, a known independent predictor of a favorable outcome in SARS-CoV2 infection, was not protective in women with a coronary calcification volume greater than 100 mm3. There were significant differences in cardiovascular comorbidities and vascular calcifications between men and women with SARS-CoV2 pneumonia. The differences in outcomes can be at least partially explained by the different cardiovascular profiles. However, women with poor outcomes had the same coronary calcific burden as men. The presumed favorable female sex bias in COVID-19 must therefore be reviewed in the context of comorbidities, especially cardiovascular ones.
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- 2021
24. Severe acute respiratory syndrome coronavirus-2-induced flare of systemic sclerosis
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Marco Matucci-Cerinic, Nicola Farina, Corrado Campochiaro, Lorenzo Dagna, Anna Palmisano, G. De Luca, Davide Vignale, Campochiaro, C., De Luca, Giacomo., Farina, N., Vignale, D., Palmisano, A., Matucci-Cerinic, M., and Dagna, L.
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2019-20 coronavirus outbreak ,Scleroderma, Systemic ,Coronavirus disease 2019 (COVID-19) ,SARS-CoV-2 ,business.industry ,musculoskeletal, neural, and ocular physiology ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Immunology ,Disease progression ,COVID-19 ,macromolecular substances ,General Medicine ,nervous system ,Rheumatology ,Humans ,Immunology and Allergy ,Medicine ,Respiratory system ,business - Abstract
Systemic sclerosis (SSc) patients may develop severe coronavirus disease 2019 (COVID-19) (1), but no reports are available on disease progression following a severe acute respiratory syndrome coron...
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- 2021
25. The spectrum of covid-19-associated myocarditis: A patient-tailored multidisciplinary approach
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Paolo Della Bella, Silvia Sartorelli, Maria Grazia Calabrò, Paola Ferro, Andrea Villatore, Alberto Margonato, Francesco De Cobelli, Giovanni Peretto, Fabrizio Monaco, Paolo G. Camici, Cristina Basso, Lorenzo Dagna, Mara Scandroglio, Monica De Gaspari, Corrado Campochiaro, Antonio Esposito, Stefania Rizzo, Giulio Cavalli, Marco Ripa, Giacomo De Luca, Evgeny Fominskiy, Moreno Tresoldi, Patrizio Mazzone, Alberto Cappelletti, Simone Sala, Anna Palmisano, Elena Busnardo, Luigi Gianolli, Davide Vignale, Peretto, G., Villatore, A., Rizzo, S., Esposito, A., De Luca, Giacomo., Palmisano, A., Vignale, D., Cappelletti, A. M., Tresoldi, M., Campochiaro, C., Sartorelli, S., Ripa, M., De Gaspari, M., Busnardo, E., Ferro, P., Calabro, M. G., Fominskiy, E., Monaco, F., Cavalli, G., Gianolli, L., De Cobelli, F., Margonato, A., Dagna, L., Scandroglio, M., Camici, P. G., Mazzone, P., Della Bella, P., Basso, C., and Sala, S.
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medicine.medical_specialty ,Myocarditis ,Cardiac magnetic resonance ,medicine.medical_treatment ,Hemodynamics ,Context (language use) ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Ventricular arrhythmias ,Internal medicine ,Biopsy ,medicine ,030212 general & internal medicine ,Heart transplantation ,Inflammation ,Ejection fraction ,Multidisciplinary ,medicine.diagnostic_test ,business.industry ,SARS-CoV-2 ,COVID-19 ,Immunosuppression ,General Medicine ,medicine.disease ,Cardiology ,Etiology ,Medicine ,Endomyocardial biopsy ,business - Abstract
Background. Myocarditis lacks systematic characterization in COVID-19 patients. Methods. We enrolled consecutive patients with newly diagnosed myocarditis in the context of COVID-19 infection. Diagnostic and treatment strategies were driven by a dedicated multidisciplinary disease unit for myocarditis. Multimodal outcomes were assessed during prospective follow-up. Results. Seven consecutive patients (57% males, age 51 ± 9 y) with acute COVID-19 infection received a de novo diagnosis of myocarditis. Endomyocardial biopsy was of choice in hemodynamically unstable patients (n = 4, mean left ventricular ejection fraction (LVEF) 25 ± 9%), whereas cardiac magnetic resonance constituted the first exam in stable patients (n = 3, mean LVEF 48 ± 10%). Polymerase chain reaction (PCR) analysis revealed an intra-myocardial SARS-CoV-2 genome in one of the six cases undergoing biopsy: in the remaining patients, myocarditis was either due to other viruses (n = 2) or virus-negative (n = 3). Hemodynamic support was needed for four unstable patients (57%), whereas a cardiac device implant was chosen in two of four cases showing ventricular arrhythmias. Medical treatment included immunosuppression (43%) and biological therapy (29%). By the 6-month median follow-up, no patient died or experienced malignant arrhythmias. However, two cases (29%) were screened for heart transplantation. Conclusions. Myocarditis associated with acute COVID-19 infection is a spectrum of clinical manifestations and underlying etiologies. A multidisciplinary approach is the cornerstone for tailored management.
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- 2021
26. Diabetes and mortality in patients with COVID-19: Are we missing the link?
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Francesco Ponticelli, Anna Palmisano, Guglielmo Gallone, Francesco Giannini, Marco Toselli, Tommaso Nannini, Alessandro Sticchi, Gianmarco Iannopollo, Riccardo Leone, Alessandra Laricchia, Antonio Colombo, Arif A Khokhar, Gianni Casella, Carlo Tacchetti, Marcello Petrini, Chiara Gnasso, Antonio Esposito, Alberto Cereda, Piergiorgio Turchio, Andrea Biagi, Francesco De Cobelli, Valeria Nicoletti, Alberto Monello, Davide Vignale, Sticchi, A., Cereda, A., Toselli, M., Esposito, A., Palmisano, A., Vignale, D., Nicoletti, V., Leone, R., Gnasso, C., Monello, A., Khokhar, A. A., Laricchia, A., Biagi, A., Turchio, P., Petrini, M., Gallone, G., De Cobelli, F., Ponticelli, F., Casella, G., Iannopollo, G., Nannini, T., Tacchetti, C., Colombo, A., and Giannini, F.
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Male ,Acute coronary syndrome ,Pediatrics ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Coronary Artery Disease ,Severity of Illness Index ,Diabetes Complications ,Coronary artery disease ,Risk Factors ,Diabetes mellitus ,Severity of illness ,Prevalence ,medicine ,Humans ,Diseases of the circulatory (Cardiovascular) system ,In patient ,Hospital Mortality ,Acute Coronary Syndrome ,Stroke ,Aged ,Aged, 80 and over ,business.industry ,Incidence ,Incidence (epidemiology) ,Age Factors ,COVID-19 ,Middle Aged ,medicine.disease ,Cardiovascular Diseases ,RC666-701 ,Regression Analysis ,Female ,business ,Scientific Letter - Published
- 2021
27. Feature tracking and mapping analysis of myocardial response to improved perfusion reserve in patients with refractory angina treated by coronary sinus Reducer implantation: a CMR study
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Antonio Esposito, Georgios Tzanis, Francesco De Cobelli, Luca Baldetti, Anna Palmisano, Francesco Ponticelli, Antonio Colombo, Marco Ancona, Giulia Benedetti, Alessandro Del Maschio, Matteo Montorfano, Davide Vignale, Guglielmo Gallone, Francesco Giannini, Caterina Beatrice Monti, Paola M.V. Rancoita, Palmisano, A., Giannini, F., Rancoita, P., Gallone, G., Benedetti, G., Baldetti, L., Tzanis, G., Vignale, D., Monti, C., Ponticelli, F., Ancona, M., Montorfano, M., Del Maschio, A., De Cobelli, F., Colombo, A., and Esposito, A.
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Male ,medicine.medical_specialty ,Cardiac Catheterization ,Time Factors ,Cardiac magnetic resonance ,Ischemia ,Diastole ,Magnetic Resonance Imaging, Cine ,030204 cardiovascular system & hematology ,Refractory angina ,Ventricular Function, Left ,Angina Pectoris ,Contractility ,03 medical and health sciences ,0302 clinical medicine ,Stress imaging ,Predictive Value of Tests ,Internal medicine ,Coronary Circulation ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Prospective Studies ,Coronary sinus ,Cardiac imaging ,Aged ,Reducer ,Ejection fraction ,Ventricular Remodeling ,business.industry ,Coronary Sinus ,Myocardial Perfusion Imaging ,ECV ,T1 mapping ,Middle Aged ,medicine.disease ,Treatment Outcome ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Perfusion - Abstract
Coronary sinus (CS) Reducer implantation improves myocardial perfusion and symptoms in patients with debilitating refractory angina. Its impact on myocardial remodeling remain uncertain. Aim of the present study was to assess possible impact of CS Reducer on myocardial systolic-diastolic deformation and microstructural remodeling, as assessed through cardiac magnetic resonance (CMR) feature tracking and mapping analysis. Twenty-eight consecutive patients with refractory angina underwent multiparametric stress CMR before and 4months after CS Reducer implantation. Eight patients were excluded (6 for absence of inducible ischemia, 2 for artifacts). Modifications in 3D systo-diastolic myocardial deformation were evaluated using feature tracking analysis on rest cine images. Myocardial microstructural remodeling was assessed by native T1 mapping, cellular and matrix volume and extracellular volume fraction (ECV). Collaterally, the percentage of ischemic myocardium (ischemic burden %) and the myocardial perfusion reserve index (MPRI) were measured. After CS Reducer implantation, myocardial contractility improved (ejection fraction rose from 61 to 67%; p = 0.0079), along with longitudinal (from − 16 to − 19%; p = 0.0192) and circumferential strain (from − 18 to − 21%; p = 0.0017). Peak diastolic radial, circumferential and longitudinal strain rate did not change (p > 0.05), and no changes in native T1, ECV, cellular and matrix volume were observed. Myocardial perfusion improved, with a reduction of ischemic burden (13–11%; p = 0.0135), and recovery of intramural perfusion balance in segments with baseline ischemia (MPRi endocardial/epicardial ratio from 0.67 to 0.96; p = 0.0107). CS Reducer improves myocardial longitudinal and circumferential strain, without microstructural remodeling and no impact on diastolic proprieties.
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- 2020
28. Acute myocarditis presenting as a reverse Tako-Tsubo syndrome in a patient with SARS-CoV-2 respiratory infection
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Mario Gramegna, Andrea Villatore, Cosmo Godino, Anna Palmisano, Giovanni Peretto, Simone Sala, Davide Vignale, Antonio Esposito, Cristina Basso, Alberto Cappelletti, Moreno Tresoldi, Francesco De Cobelli, Sala, S., Peretto, G., Gramegna, M., Palmisano, A., Villatore, A., Vignale, D., De Cobelli, F., Tresoldi, M., Cappelletti, A. M., Basso, C., Godino, C., and Esposito, A.
- Subjects
Adult ,medicine.medical_specialty ,Myocarditis ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Thoracic ,Pneumonia, Viral ,Betacoronavirus ,Coronary Angiography ,Coronavirus Infections ,Female ,Humans ,Pandemics ,Radiography, Thoracic ,Takotsubo Cardiomyopathy ,Tomography, X-Ray Computed ,Internal medicine ,Medicine ,Viral ,Tomography ,Respiratory tract infections ,biology ,business.industry ,SARS-CoV-2 ,Discussion Forum ,Respiratory infection ,COVID-19 ,Pneumonia ,medicine.disease ,biology.organism_classification ,X-Ray Computed ,Radiography ,Acute myocarditis ,Cardiology ,Tako tsubo ,business ,Cardiology and Cardiovascular Medicine - Published
- 2020
29. Single-shot morpho-functional and structural characterization of the left-ventricle in a mouse model of acute ischemia-reperfusion injury with an optimized 3D IntraGate cine FLASH sequence at 7T MR
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Angela Napolitano, Paola Signorelli, Caterina Beatrice Monti, Federica Cirillo, Anna Palmisano, Luigi Anastasia, Marco Piccoli, Davide Vignale, Tamara Canu, Laura Perani, Antonio Esposito, Palmisano, A., Piccoli, M., Monti, C. B., Canu, T., Cirillo, F., Napolitano, A., Perani, L., Signorelli, P., Vignale, D., Anastasia, L., and Esposito, A.
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Male ,Heart Ventricles ,Biomedical Engineering ,Biophysics ,Magnetic Resonance Imaging, Cine ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Text mining ,Imaging, Three-Dimensional ,medicine ,Medical imaging ,Animals ,Radiology, Nuclear Medicine and imaging ,Reproducibility ,Ejection fraction ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Magnetic resonance imaging ,medicine.disease ,Mice, Inbred C57BL ,medicine.anatomical_structure ,Parasternal line ,Ventricle ,Echocardiography ,Reperfusion Injury ,Nuclear medicine ,business ,Reperfusion injury ,030217 neurology & neurosurgery - Abstract
Preclinical cardiac MR is challenging and time-consuming. A fast and comprehensive acquisition protocol and standardized image post-processing may improve preclinical research, reducing acquisition time, costs and variability of results. In the present study, we evaluated the feasibility of a contrast-enhanced 3D IntraGate steady-state cine sequence (ce-3D-IG-cine) with short acquisition time (11 min) for a single-shot combined characterization of left ventricle (LV) remodeling and infarct size (IS) in a mouse model of acute ischemia-reperfusion injury. Sixteen male C57BL/6N mice underwent 7T cardiac MR (Bruker, BioSpec 70/30) including optimized ce-3D-IG-cine (total scan time 11 min) at day 1, 5 and 28 after surgery. LV end-diastolic volume (EDVMR) and ejection fraction (EFMR) extracted from MR were compared to ones from short-axis (SA-EDVecho, SA-EFecho) and parasternal long-axis (LA-EDVecho, LA-EFecho) echocardiography. IS was manually and semiautomatically segmented from ce-3D-IG-cine using different standard deviation (SD +2, +3, +4, +5, +6 in respect to a reference tissue). Mice were sacrificed at day 28, immediately after imaging. IS at day 28 was compared to injury burden at histology. MR and echocardiographic morpho-functional parameters were compared, as IS from MR and histology. Bland-Altman plots were used to assess the agreement in ischemic burden segmentation. Volumetric and functional parameters measured on ce-3D-IG-cine correlated to the correspondent echocardiographic parameter (EDVMR vs SA-EDVecho: ρ = 0.813; EDVMR vs LA-EDVecho: ρ = 0.845; EFMR vs SA-EFecho ρ = 0.612; EFMR vs LA-EFecho ρ = 0.791; p < 0.001 in all cases). Manually segmented IS strongly correlated with the scar at histology (ρ = 0.904, p < 0.001). A threshold of +3SD showed the highest performance for semiautomatic assessment of IS compared to manual segmentation (ρ = 0.965, p < 0.001), with an overall reproducibility of 73%, and a peak reproducibility of 80% at day 1. The ce-3D-IG-cine sequence, manually or semiautomatically segmented using 3SD threshold, allows fast and comprehensive LV morpho-functional and structural characterization in myocardial ischemia-reperfusion injury model.
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- 2020
30. Cardiac Magnetic Resonance Characterization of Myocarditis-Like Acute Cardiac Syndrome in COVID-19
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Giovanni Peretto, Luigi Natale, Antonio Esposito, Vincenzo Russo, Riccardo Marano, Davide Vignale, Anna Palmisano, Luigi Lovato, Guido Ligabue, Federica Fiocchi, Esposito, A., Palmisano, A., Natale, L., Ligabue, G., Peretto, G., Lovato, L., Vignale, D., Fiocchi, F., Marano, R., and Russo, V.
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Male ,Respiratory complications ,medicine.medical_specialty ,Systemic disease ,Myocarditis ,Coronavirus disease 2019 (COVID-19) ,Left ,Magnetic Resonance Imaging, Cine ,030204 cardiovascular system & hematology ,medicine.disease_cause ,Ventricular Function, Left ,Article ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Internal medicine ,medicine ,Ventricular Function ,Humans ,Radiology, Nuclear Medicine and imaging ,Respiratory system ,Coronavirus ,Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA ,COVID-19 ,Female ,Italy ,Middle Aged ,Prognosis ,Syndrome ,medicine.diagnostic_test ,business.industry ,Acute Myocardial Injury ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,N/A ,Cine ,Radiology Nuclear Medicine and imaging ,SARS-CoV2 ,Cardiology ,Takotsubo cardiomyopathy ,Cardiac magnetic resonance ,business ,Cardiology and Cardiovascular Medicine - Abstract
Novel coronavirus infection causes a systemic disease (coronavirus disease-2019 [COVID-19]) with, most frequently, respiratory involvement. In addition to systemic and respiratory complications, COVID-19 can reveal itself as a myocarditis-like syndrome (AMCovS), whose underlying mechanism is largely
- Published
- 2020
31. Multimodality imaging in chronic heart failure
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Antonio Esposito, Gianluca Milanese, Scipione Carerj, Annamaria Di Cesare, Maria Ludovica Carerj, Ernesto Di Cesare, Federica Catapano, Marco Francone, Anna Palmisano, Nicola Sverzellati, Davide Vignale, Di Cesare, E., Carerj, S., Palmisano, A., Carerj, M. L., Catapano, F., Vignale, D., Di Cesare, A., Milanese, G., Sverzellati, N., Francone, M., and Esposito, A.
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medicine.medical_specialty ,Cardiac output ,Cardiac magnetic resonance ,Heart failure ,Multimodal Imaging ,030218 nuclear medicine & medical imaging ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Computed tomography ,cardiac magnetic resonance ,chronic heart failure ,computed tomography ,dchocardiography ,heart failure ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Cardiac magnetic resonance, Chronic heart failure, Computed tomography, Echocardiography, Heart failure ,Ultrasound ,Interventional radiology ,General Medicine ,Gold standard (test) ,Prognosis ,medicine.disease ,Chronic heart failure ,Echocardiography ,030220 oncology & carcinogenesis ,Chronic Disease ,Etiology ,Cardiology ,business - Abstract
The prevalence of heart failure (HF) is approximately 1-2% of the adult population in developed countries, rising to ≥ 10% among people over 70. The common symptoms of HF include shortness of breath, ankle swelling and fatigue, determined by a reduced cardiac output. Multimodality imaging is crucial to define HF etiology, determine prognosis and guiding tailored treatments. Echocardiography is the most widely used imaging modality and maintains a pivotal role in the initial diagnostic work-up and in the follow-up of HF patients. Cardiac magnetic resonance (CMR) may support the morpho-functional assessment provided by echocardiography when the acoustic window is limited or a gold standard evaluation is required. Furthermore, CMR is frequently used due to the unmatched capability to characterize myocardial structure. Coronary computed tomography angiography has become the non-invasive imaging of choice to diagnose or rule-out coronary artery disease, acquiring remarkable importance in the management of HF patients. Moreover, emerging capabilities of CT-based tissue characterization may be useful, especially when CMR is contraindicated. Finally, chest CT may contribute to precisely define the framework of HF patients, revealing new insight about cardiopulmonary pathophysiological interactions with potential high prognostic value.
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- 2020
32. Clinically isolated aortitis successfully treated with methotrexate monotherapy
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Lorenzo Dagna, Alessandro Tomelleri, Anna Palmisano, Silvia Sartorelli, Corrado Campochiaro, Davide Vignale, Antonio Esposito, Sartorelli, S., Tomelleri, A., Palmisano, A., Vignale, D., Esposito, A., Dagna, L., and Campochiaro, C.
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Male ,medicine.medical_specialty ,Aortitis ,business.industry ,Treatment outcome ,MEDLINE ,Aftercare ,Blood Sedimentation ,medicine.disease ,Text mining ,C-Reactive Protein ,Methotrexate ,Treatment Outcome ,Rheumatology ,Internal medicine ,Antirheumatic Agents ,Positron Emission Tomography Computed Tomography ,Medicine ,Humans ,Pharmacology (medical) ,business ,medicine.drug ,Aged - Published
- 2019
33. USOS MEDICINALES Y CONOCIMIENTOS NUTRACÉUTICOS ANCESTRALES DE LA QUINUA (Chenopodium quinoa Willd.) Y PARIENTES SILVESTRES EN EL ALTIPLANO PERUANO.
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Mujica, A., Moscoso, G., Zavaleta, A., Canahua, A., Chura, E., Pocco, M, and Vignale, D.
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- *
QUINOA , *AGRICULTURE , *PERUVIAN cooking , *NUTRITION , *NUTRITIONAL value , *COOKING - Abstract
El artículo discurre sobre los beneficios de la quinua (Chenopodium quinoa) a la salud. Los autores comentan sobre los usos medicinales de la quinua y examina los aspectos nutricionales. También se considera el cultivo de diversos variedades de la quinua en Perú y se describe su consumo tradicional en la cocina peruana.
- Published
- 2015
34. Myocarditis Following Pembrolizumab Plus Axitinib, and Belzutifan Plus Lenvatinib for Renal Cell Carcinoma: A Case Report.
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Villatore A, Bosi C, Pomaranzi C, Cigliola A, Tateo V, Mercinelli C, Vignale D, Rizzo S, Necchi A, and Peretto G
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- Humans, Female, Middle Aged, Treatment Outcome, Protein Kinase Inhibitors adverse effects, Immune Checkpoint Inhibitors adverse effects, Carcinoma, Renal Cell drug therapy, Quinolines adverse effects, Kidney Neoplasms drug therapy, Kidney Neoplasms pathology, Antibodies, Monoclonal, Humanized adverse effects, Antineoplastic Combined Chemotherapy Protocols adverse effects, Axitinib adverse effects, Myocarditis chemically induced, Myocarditis diagnosis, Phenylurea Compounds adverse effects
- Abstract
Cardiac toxicity is an adverse event of several classes of anti-cancer drugs. Herein, we present the case of a 52-year-old woman with metastatic renal cell carcinoma (RCC), previously treated with debulking surgery, pembrolizumab (immune checkpoint inhibitor) in combination with axitinib (tyrosine kinase inhibitor (TKI)), followed by lenvatinib (TKI) and belzutifan (HIF-2α inhibitor), who developed myocarditis proven by cardiac magnetic resonance and endomyocardial biopsy. The case was notable for reporting a not-yet described adverse event during treatment with belzutifan plus lenvatinib, the etiology of which was of unobvious determination given the pre-exposure to pembrolizumab, a known cause of drug-related myocarditis. We surmise that myocarditis was a delayed adverse event related to pembrolizumab (8 months after treatment interruption), although we emphasize that only attentive monitoring of cardiac adverse events of patients exposed to belzutifan and lenvatinib in the context of large clinical trials may rule out any causal implication of these drugs., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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35. Cardiovascular magnetic resonance parametric mapping in the risk stratification of patients affected by chronic myocarditis.
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Vignale D, Bruno E, Palmisano A, Barbieri S, Bartoli A, Peretto G, Villatore A, De Luca G, and Esposito A
- Abstract
Objectives: Chronic myocardial inflammation is the substrate for arrhythmias and dilated cardiomyopathy onset, causing morbidity and mortality. Cardiovascular magnetic resonance (CMR) is the noninvasive gold standard for myocardial inflammation detection, due to the high sensitivity of the parametric mapping techniques. However, the potential prognostic capabilities of CMR mapping have not been studied in the setting of chronic myocarditis., Methods: This is a retrospective study on consecutive patients undergoing CMR with suspicion of chronic myocarditis from September 2017 to November 2021. CMR was acquired according to 2018 Lake Louise Criteria recommendations. The outcome (chronic heart failure, recurrent chronic myocarditic chest pain, ICD/PM implantation, arrhythmias [Lown class ≥ 2]) was collected at follow-up. The extent and degree of native T1, T2, and extracellular volume fraction alterations were used to create multivariate binary logistic regression models for outcome prediction, with or without left ventricle ejection fraction; their AUCs were compared with DeLong test. Differences between other parameters were assessed using Chi-square test, Fisher's exact test, or Mann-Whitney U-test., Results: The population included 88 patients (age 43 [32-52] yo), mostly male (53/88, 60%). After a median follow-up of 21 (17-34) months, 31/88 (35%) patients experienced the outcome. The model based on the extension of mapping alterations and LV dysfunction reached a good predictability (AUC 0.71). The model based on the intensity of mapping alterations and LV dysfunction had a very good performance (AUC 0.80)., Conclusion: The quantitative analysis of CMR mapping parameters indicative of myocardial damage severity may improve risk stratification in patients with chronic myocarditis., Clinical Relevance Statement: The intensity of myocardial damage, assessed as the degree of native T1, T2, and ECV alteration, together with left ventricle dysfunction, improved patient risk stratification. Further prospective studies will be necessary for validation before clinical application., Key Points: Risk stratification of patients affected by chronic myocarditis is an unmet clinical need. Cardiovascular MRI (CMR) can role in risk stratification thanks to its multiparametric capabilities of tissue characterization. A model based on CMR parametric mapping and left ventricle ejection fraction can predict arrhythmia, heart failure, and recurrent symptoms., (© 2024. The Author(s), under exclusive licence to European Society of Radiology.)
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- 2024
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36. Myocarditis in anti-synthetase syndrome: clinical features and diagnostic modalities.
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De Luca G, Campochiaro C, Palmisano A, Bruno E, Vignale D, Peretto G, Sala S, Ferlito A, Cilona MB, Esposito A, Matucci-Cerinic M, and Dagna L
- Subjects
- Humans, Female, Male, Middle Aged, Retrospective Studies, Aged, Troponin T blood, Natriuretic Peptide, Brain blood, Magnetic Resonance Imaging methods, Peptide Fragments blood, Myocarditis diagnostic imaging, Myocarditis diagnosis, Myositis diagnosis, Myositis complications
- Abstract
Objectives: Myocarditis is an overlooked manifestation of anti-synthetase syndrome (ASS). Our study describes the clinical and instrumental features of ASS myocarditis and evaluates the performance of cardiac MRI (CMRI) with mapping techniques in assisting diagnosis of ASS myocarditis., Methods: Data from patients with ASS were retrospectively analysed. CMRI data for patients diagnosed with myocarditis, including late gadolinium enhancement (LGE), T2 ratio, T1 mapping, extracellular volume (ECV) and T2 mapping, were reviewed. Myocarditis was defined by the presence of symptoms and/or signs suggestive for heart involvement, including increased high-sensitive troponin T (hs-TnT) and/or N-terminal pro-brain natriuretic peptide (NT-proBNP), and at least an instrumental abnormality. The clinical features of patients with ASS with and without myocarditis were compared. A P-value of <0.05 was considered statistically significant., Results: Among a cohort of 43 patients with ASS [median age 58 (48.0-66.0) years; females 74.4%; anti-Jo1 53.5%], 13 (30%) were diagnosed with myocarditis. In 54% of those 13 patients, myocarditis was diagnosed at clinical onset. All patients with ASS with myocarditis had at least one CMRI abnormality: increased ECV in all cases, presence of LGE in 91%, and increased T1 and T2 mapping in 91%. The 2009 Lake Louise criteria (LLC) were satisfied by 6 patients, and the 2018 LLC by 10 patients. With the updated LLC, the sensitivity for myocarditis improved from 54.6% to 91.0%. Patients with ASS with myocarditis were more frequently males (53% vs 13%; P = 0.009) with fever (69% vs 17%; P = 0.001), and had higher hs-TnT [88.0 (23.55-311.5) vs 9.80 (5.0-23.0) ng/l; P < 0.001], NT-proBNP [525.5 (243.5-1575.25) vs 59.0 (32.0-165.5; P = 0.013) pg/ml; P = 0.013] and CRP [7.0 (1.7-15.75) vs 1.85 (0.5-2.86) mg/l; P = 0.011] compared with those without myocarditis., Conclusion: In ASS, myocarditis is frequent, even at clinical onset. Patients with ASS with myocarditis frequently presented with fever and increased CRP, suggesting the existence of an inflammatory phenotype. The use of novel CMRI mapping techniques may increase diagnostic sensitivity for myocarditis in ASS., (© The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology.)
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- 2024
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37. Effectiveness and safety of mycophenolate mofetil and rituximab combination therapy for immune idiopathic myopathies.
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Campochiaro C, Farina N, De Luca G, Batani V, Trignani G, Vignale D, Palmisano A, Matucci-Cerinic M, and Dagna L
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- Humans, Female, Middle Aged, Male, Rituximab adverse effects, Retrospective Studies, Treatment Outcome, Mycophenolic Acid adverse effects, Myositis drug therapy, Myositis chemically induced
- Abstract
Introduction: Idiopathic inflammatory myopathies (IIM) represent a rare and heterogenous group diseases, and their treatment is not fully defined yet. According to previous small case series, the combination of mycophenolate mofetil (MMF) and rituximab (RTX) may be effective in controlling difficult-to-treat patients. Our aim was to further explore the efficacy and safety of this combined approach in patients with IIM., Methods: Patients with IIM treated with the RTX/MMF combination in our Center were retrospectively identified. After the start of combination therapy, the efficacy was evaluated at 12 months (T12) according the 2016 ACR/EULAR response criteria for IIM. Cardiac imaging and pulmonary function tests were used to monitor disease activity in patients with myocarditis and interstitial lung disease, respectively. Adverse events were recorded over the follow-up period., Results: Among the 20 patients (median age 61 years; 70% female) included in the study, anti-synthetase syndrome was the most prevalent IIM subgroup (60%). At treatment start, muscle, heart, and lung were the most commonly actively affected organs. After 12 months, a moderate or major response was observed in all patients, and creatine kinase was significantly decreased (p-value = 0.012). Cardiac imaging and enzymes monitoring showed a reduction of heart inflammation, while pulmonary function tests improved in patients with lung involvement. No severe side effects were observed., Conclusion: Our data show that combination of RTX and MMF is effective and safe in patients with severe and refractory IIM. Therefore, this combined treatment might represent a feasible approach for difficult-to-treat IIM cases., (© 2024. The Author(s).)
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- 2024
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38. Cardiac Wolframinopathies: A Case Report of Myocarditis and a Literature Review of Cardiac Involvement in Wolfram Syndrome 1.
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Villatore A, Frontino G, Cascavilla ML, Vignale D, Lazzeroni D, and Peretto G
- Abstract
Purpose : Myocarditis is frequently a sporadic disease, but may also occur in the context of genetic disorders which may increase susceptibility to cardiac inflammation. Cardiac involvement in Wolfram syndrome type 1 (WS1) has been scarcely characterized. To our knowledge, no cases of virus-negative myocarditis have been reported in the WS1 pediatric population. Methods : We report the description of a pediatric case of acute myocarditis in the context of WS1, followed by a literature review of cardiovascular involvement associated with wolframin variants, and discuss potential pathophysiological mechanisms and therapeutic options. Results : A young patient with WS1, treated with insulin and liraglutide, was admitted for acute chest pain. Cardiac magnetic resonance and endomyocardial biopsy were performed to confirm the clinical suspicion of myocarditis. While congenital heart diseases and arrhythmias have been described previously in patients with WS1, this is the first description of virus-negative myocarditis. Conclusions : Myocarditis may represent a possible manifestation of cardiovascular involvement in WS1. Cardiovascular screening may be considered in patients with WS1.
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- 2024
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39. Value of a short non-contrast CMR protocol in MINOCA.
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Gatti M, Palmisano A, Gerboni M, Cau R, Pintus A, Porcu M, Tore D, Vignale D, Andreis A, Bergamasco L, De Ferrari GM, Esposito A, Saba L, Fonio P, and Faletti R
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- Humans, MINOCA, Retrospective Studies, Myocardium pathology, Multicenter Studies as Topic, Myocarditis, Myocardial Infarction diagnosis
- Abstract
Objectives: To evaluate the diagnostic performance of a short non-contrast CMR (ShtCMR) protocol relative to a matched standard comprehensive CMR (StdCMR) protocol in patients with myocardial infarction with non-obstructive coronary arteries (MINOCA)., Methods: This multicenter retrospective study included patients with a working diagnosis of MINOCA who underwent a StdCMR between January 2019 and December 2020. An expert and a non-expert reader performed a blinded reading with the ShtCMR (long-axis cine images, T2w-STIR, T1- and T2-mapping). A consensus reading of the StdCMR (reference standard) was performed at least 3 months after the ShtCMR reading session. Readers were asked to report the following: (1) diagnosis; (2) level of confidence in their diagnosis with the ShtCMR; (3) number of myocardial segments involved, and (4) functional parameters., Results: A total of 179 patients were enrolled. The ShtCMR lasted 21 ± 9 min and the StdCMR 45 ± 11 min (p < 0.0001). ShtCMR allowed reaching the same diagnosis as StdCMR in 85% of patients when interpreted by expert readers (rising from 66% for poor confidence to 99% for good, p = 0.0001) and in 73% (p = 0.01) by non-expert ones (60% for poor vs 89% for good confidence, p = 0.0001). Overall, the ShtCMR overestimated the ejection fraction, underestimated cardiac volumes (p < 0.01), and underestimated the number of segments involved by pathology (p = 0.0008) when compared with the StdCMR., Conclusion: The ShtCMR was found to be a debatable alternative to the StdCMR in patients with MINOCA. Nevertheless, when an experienced reader reaches a good or very good diagnostic confidence using the ShtCMR, the reader may choose to stop the examination, reducing the length of the CMR without affecting the patient's diagnosis., Clinical Relevance Statement: A short non-contrast CMR protocol may be a viable alternative to standard protocols in selected CMR studies of patients with MINOCA, allowing for faster diagnosis while reducing time and resources and increasing the number of patients who can be scanned., Key Points: • The ShtCMR lasted 21 ± 9 min and the StdCMR 45 ± 11 min (p < 0.0001). • In 57% of patients with MINOCA, the experienced reader considers that contrast medium is probably not necessary for diagnosis without affecting the patient's diagnosis (99% of agreement rate between ShtCMR and StdCMR)., (© 2023. The Author(s).)
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- 2024
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40. Clinical profiling and outcomes of viral myocarditis manifesting with ventricular arrhythmias.
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Peretto G, Sala S, Carturan E, Rizzo S, Villatore A, De Luca G, Campochiaro C, Palmisano A, Vignale D, De Gaspari M, Dagna L, Esposito A, Basso C, Camici PG, and Della Bella P
- Abstract
Aims: Clinical features and risk stratification of patients with viral myocarditis (VM) complicated by ventricular arrhythmias (VA) are incompletely understood. We aim to describe arrhythmia patterns and outcomes in patients with VM and early-onset VA., Methods and Results: We present a single-centre study, enrolling patients with VM proven by endomyocardial biopsy, and evidence of VA within 24 h of hospitalization. The incidence of major adverse events (MAE), including all-cause death, severe heart failure, advanced atrioventricular blocks, or major VA, was evaluated during a 24-month follow-up (FU) and compared with a matched group of virus-negative myocarditis. Of patients with VM ( n = 74, mean age 47 ± 16 years, 66% males, and left ventricular ejection fraction 51 ± 13%), 20 (27%) presented with major VA [ventricular tachycardia/ventricular fibrillation (VT/VF)], and 32 (44%) had polymorphic VA. Patients with polymorphic VA more commonly had evidence of ongoing systemic infection (24/32 vs. 10/42, P = 0.004) and experienced greater occurrence of MAE at discharge (15/32 vs. 2/42, P < 0.001). However, the incidence of MAE during FU was higher in patients with monomorphic VA compared to those with polymorphic VA (17/42 vs. 2/28, P = 0.002). Patients with monomorphic VA displayed frequently signs of chronic cardiomyopathy and had outcomes comparable with virus-negative myocarditis (log rank P = 0.929). Presentation with VT/VF was independently associated with MAE [at discharge: hazard ratio (HR) 4.7, 95% confidence interval (CI) 1.6-14.0, P = 0.005; during FU: HR 6.3, 95% CI 2.3-17.6, P < 0.001]., Conclusion: In patients with VM, polymorphic VA point to ongoing systemic infection and early adverse outcomes, whereas monomorphic VA suggest chronic cardiomyopathy and greater incidence of MAE during FU. Presentation with VT/VF is independently associated with MAE., Competing Interests: Conflict of interest: none declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2023
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41. Chest CT opportunistic biomarkers for phenotyping high-risk COVID-19 patients: a retrospective multicentre study.
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Palmisano A, Gnasso C, Cereda A, Vignale D, Leone R, Nicoletti V, Barbieri S, Toselli M, Giannini F, Loffi M, Patelli G, Monello A, Iannopollo G, Ippolito D, Mancini EM, Pontone G, Vignali L, Scarnecchia E, Iannaccone M, Baffoni L, Spernadio M, de Carlini CC, Sironi S, Rapezzi C, and Esposito A
- Subjects
- Male, Humans, Aged, Female, Retrospective Studies, SARS-CoV-2, Hospital Mortality, Tomography, X-Ray Computed methods, Biomarkers, COVID-19, Fatty Liver, Osteoporosis, Cardiovascular Diseases
- Abstract
Objective: To assess the value of opportunistic biomarkers derived from chest CT performed at hospital admission of COVID-19 patients for the phenotypization of high-risk patients., Methods: In this multicentre retrospective study, 1845 consecutive COVID-19 patients with chest CT performed within 72 h from hospital admission were analysed. Clinical and outcome data were collected by each center 30 and 80 days after hospital admission. Patients with unknown outcomes were excluded. Chest CT was analysed in a single core lab and behind pneumonia CT scores were extracted opportunistic data about atherosclerotic profile (calcium score according to Agatston method), liver steatosis (≤ 40 HU), myosteatosis (paraspinal muscle F < 31.3 HU, M < 37.5 HU), and osteoporosis (D12 bone attenuation < 134 HU). Differences according to treatment and outcome were assessed with ANOVA. Prediction models were obtained using multivariate binary logistic regression and their AUCs were compared with the DeLong test., Results: The final cohort included 1669 patients (age 67.5 [58.5-77.4] yo) mainly men 1105/1669, 66.2%) and with reduced oxygen saturation (92% [88-95%]). Pneumonia severity, high Agatston score, myosteatosis, liver steatosis, and osteoporosis derived from CT were more prevalent in patients with more aggressive treatment, access to ICU, and in-hospital death (always p < 0.05). A multivariable model including clinical and CT variables improved the capability to predict non-critical pneumonia compared to a model including only clinical variables (AUC 0.801 vs 0.789; p = 0.0198) to predict patient death (AUC 0.815 vs 0.800; p = 0.001)., Conclusion: Opportunistic biomarkers derived from chest CT can improve the characterization of COVID-19 high-risk patients., Clinical Relevance Statement: In COVID-19 patients, opportunistic biomarkers of cardiometabolic risk extracted from chest CT improve patient risk stratification., Key Points: • In COVID-19 patients, several information about patient comorbidities can be quantitatively extracted from chest CT, resulting associated with the severity of oxygen treatment, access to ICU, and death. • A prediction model based on multiparametric opportunistic biomarkers derived from chest CT resulted superior to a model including only clinical variables in a large cohort of 1669 patients suffering from SARS- CoV2 infection. • Opportunistic biomarkers of cardiometabolic comorbidities derived from chest CT may improve COVID-19 patients' risk stratification also in absence of detailed clinical data and laboratory tests identifying subclinical and previously unknown conditions., (© 2023. The Author(s).)
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- 2023
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42. Multimodal Detection and Targeting of Biopsy-Proven Myocardial Inflammation in Genetic Cardiomyopathies: A Pilot Report.
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Peretto G, De Luca G, Villatore A, Di Resta C, Sala S, Palmisano A, Vignale D, Campochiaro C, Lazzeroni D, De Gaspari M, Rizzo S, Busnardo E, Ferro P, Gianolli L, Basso C, Dagna L, Esposito A, Benedetti S, and Della Bella P
- Abstract
The authors present a clinical report focused on the overlap between myocarditis and genetic cardiomyopathies of the dilated and arrhythmogenic spectrum. Our cohort was composed of 25 patients undergoing extensive baseline characterization and prospective reassessment by a dedicated multidisciplinary disease unit during a median follow-up of 69 months. We showed that the use of multimodal imaging allowed both discrimination of specific genotypes and identification of myocardial inflammation proven using endomyocardial biopsy. In addition, we showed that the use of immunomodulatory therapy was beneficial for most patients., Competing Interests: The authors have reported that they have no relationships relevant to the contents of this paper to disclose., (© 2023 The Authors.)
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- 2023
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43. Extracellular volume fraction (ECV) derived from pre-operative computed tomography predicts prognosis in patients undergoing transcatheter aortic valve implantation (TAVI).
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Vignale D, Palmisano A, Gnasso C, Margonato D, Romagnolo D, Barbieri S, Ingallina G, Stella S, Ancona MB, Montorfano M, Maisano F, Agricola E, and Esposito A
- Subjects
- Humans, Stroke Volume, Treatment Outcome, Prospective Studies, Ventricular Function, Right, Prognosis, Aortic Valve surgery, Fibrosis, Tomography, X-Ray Computed, Tomography, Ventricular Function, Left, Transcatheter Aortic Valve Replacement adverse effects, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery
- Abstract
Aims: Transcatheter aortic valve implantation (TAVI) is the treatment of choice for high-risk patients with severe aortic stenosis (AS). A portion of TAVI recipients has no long-term clinical benefit, and myocardial fibrosis may contribute to unfavourable outcomes. We aimed to assess the prognostic value of an interstitial fibrosis marker, extracellular volume fraction (ECV), measured at planning computed tomography (CT) before TAVI., Methods and Results: From October 2020 to July 2021, 159 consecutive patients undergoing TAVI planning CT were prospectively enroled. ECV was calculated as the ratio of myocardium and blood pool differential attenuations before and 5 min after contrast administration, pondered for haematocrit. A composite endpoint including heart failure hospitalization (HFH) and death was collected by telehealth or in-person follow-up visits in the 113 patients constituting the final study population. Cox proportional hazards model was used to assess association between ECV and the composite endpoint.Median follow-up was 13 (11-15) months. The composite endpoint occurred in 23/113 (20%) patients. These patients had lower aortic valve mean pressure gradient [39 (29-48) vs. 46 (40-54) mmHg, P = 0.002] and left ventricular and right ventricular ejection fraction [51 (37-69) vs. 66 (54-74)%, P = 0.014; 45 (31-53) vs. 49 (44-55)%, P = 0.010] and higher ECV [31.5 (26.9-34.3) vs. 27.8 (25.3-30.2)%, P = 0.006]. At multivariable Cox analysis, ECV higher than 31.3% was associated to increased risk of death or HFH at follow-up (hazard ratio = 5.92, 95% confidence interval 2.37-14.75, P < 0.001)., Conclusion: In this prospective observational cohort study, ECV measured at TAVI planning CT predicts the composite endpoint (HFH or death) in high-risk severe AS patients., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2023
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44. Cardiac magnetic resonance findings in acute and post-acute COVID-19 patients with suspected myocarditis.
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Palmisano A, Vignale D, Bruno E, Peretto G, De Luca G, Campochiaro C, Tomelleri A, Agricola E, Montorfano M, and Esposito A
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- Male, Humans, Female, Predictive Value of Tests, SARS-CoV-2, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Contrast Media, Myocarditis complications, Myocarditis diagnostic imaging, COVID-19 complications, Cardiomyopathies
- Abstract
Introduction: Cardiac injury is commonly reported in COVID-19 patients, resulting associated to pre-existing cardiovascular disease, disease severity, and unfavorable outcome. Aim is to report cardiac magnetic resonance (CMR) findings in patients with myocarditis-like syndrome during the acute phase of SARS-CoV-2 infection (AMCovS) and post-acute phase (cPACS)., Methods: Between September 2020 and January 2022, 39 consecutive patients (24 males, 58%) were referred to our department to perform a CMR for the suspicion of myocarditis related to AMCovS (n = 17) and cPACS (n = 22) at multimodality evaluation (clinical, laboratory, ECG, and echocardiography). CMR was performed for the assessment of volume, function, edema and fibrosis with standard sequences and mapping techniques. CMR diagnosis and the extension and amount of CMR alterations were recorded., Results: Patients with suspected myocarditis in acute and post-COVID settings were mainly men (10 (59%) and 12 (54.5%), respectively) with older age in AMCovS (58 [48-64]) compared to cPACS (38 [26-53]). Myocarditis was confirmed by CMR in most of cases: 53% of AMCovS and 50% of cPACS with negligible LGE burden (3 [IQR, 1-5] % and 2 [IQR, 1-4] %, respectively). Myocardial infarction was identified in 4/17 (24%) patients with AMCovS. Cardiomyopathies were identified in 12% (3/17) and 27% (6/22) of patients with AMCovS and cPACS, including DCM, HCM and mitral valve prolapse., Conclusions: In patients with acute and post-acute COVID-19 related suspected myocarditis, CMR improves diagnostic accuracy characterizing ischemic and non-ischemic injury and unraveling subclinical cardiomyopathies., (© 2022 The Authors. Journal of Clinical Ultrasound published by Wiley Periodicals LLC.)
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- 2023
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45. Cardiovascular involvement in Erdheim-Chester diseases is associated with myocardial fibrosis and atrial dysfunction.
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Palmisano A, Campochiaro C, Vignale D, Tomelleri A, De Luca G, Bruno E, Monti CB, Cavalli G, Dagna L, and Esposito A
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- Male, Humans, Female, Constriction, Pathologic complications, Vena Cava, Superior, Fibrosis, Erdheim-Chester Disease complications, Erdheim-Chester Disease diagnostic imaging, Atrial Fibrillation, Cardiomyopathies complications
- Abstract
Purpose: Erdheim-Chester disease (ECD) is a rare multisystem histiocytosis, whose cardiovascular involvement has not been systematically characterized so far. We aimed to systematically (qualitatively and quantitatively) describe the features of cardiovascular involvement in a large cohort of ECD patients and to evaluate its impact on myocardial fibrosis extension and cardiac function., Material and Methods: Among 54 patients with biopsy-proven ECD, 29 patients (59 ± 12 years, 79% males) underwent 1.5-T CMR using a standardized protocol for qualitative and quantitative assessment of disease localization, evaluation of atrial and ventricular function, and assessment of non-dense and dense myocardial fibrosis., Results: The right atrioventricular (AV) groove was the most commonly affected cardiac site (76%) followed by the right atrial walls (63%), thoracic aorta (59%), and superior vena cava (38%). Right AV groove involvement, encasing the right ventricular artery, was associated with non-dense myocardial fibrosis in the infero-septal (20/26 patients) and the inferior (14/26 patients) mid-basal left ventricular (LV) wall. In two patients with right AV groove localization, LGE revealed myocardial infarction in the same myocardial segments. Three out of five patients with left AV groove involvement had non-dense LGE on the lateral LV mid-basal wall. Bulky right atrial pseudomass was associated with atrial dysfunction and superior and inferior vena cava stenosis., Conclusions: In ECD patients, AV groove localization is associated with LV wall fibrosis in the downstream coronary territories, suggesting hemodynamic alterations due to coronary encasement. Conversely, atrial pseudomass ECD localizations impact on atrial contractility causing atrial dysfunction and are associated with atrio-caval junction stenosis., (© 2023. The Author(s).)
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- 2023
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46. Cardiac magnetic resonance abnormalities in patients with acute myocarditis proven by septal endomyocardial biopsy.
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Peretto G, Merlo M, Gentile P, Porcari A, Palmisano A, Vignale D, Sormani P, Rizzo S, De Gaspari M, Basso C, Bella PD, Sala S, Ammirati E, Sinagra G, Esposito A, and Pedrotti P
- Subjects
- Male, Humans, Young Adult, Adult, Middle Aged, Female, Retrospective Studies, Stroke Volume, Contrast Media, Ventricular Function, Left, Gadolinium, Magnetic Resonance Imaging methods, Biopsy, Magnetic Resonance Spectroscopy, Magnetic Resonance Imaging, Cine methods, Myocardium pathology, Myocarditis diagnosis, Heart Defects, Congenital
- Abstract
Background: Previous studies suggest low diagnostic sensitivity of cardiac magnetic resonance (CMR) imaging based on Lake Louise criteria (LLC) to identify patients with complicated presentations of acute myocarditis (AM). We evaluated classic and updated LLC in patients with AM proven by right ventricular septal endomyocardial biopsy (RVS-EMB)., Methods: From an initial population of 499 patients with clinically suspected AM from a multicenter retrospective cohort, we included 74 patients with histologically proven myocarditis on RVS-EMB and available CMR within 30 days since admission. The prevalence of total and septal CMR abnormalities [namely, T2-weighted images (T2W), late gadolinium enhancement (LGE), T2 and T1 mapping, and extracellular volume (ECV)] were assessed in patients with complicated vs. uncomplicated AM., Results: Among 74 patients [mean age 38 ± 15 years, 65% males, left ventricular ejection fraction (LVEF) 40 ± 18%] with RVS-EMB-proven AM, 53 (72%) had a complicated presentation. The classic LLC were positive in 56/74 patients (76%), whereas the updated ones were positive in 41/41 of cases (100%). Septal involvement, documented in 48/74 patients (65%) by conventional T2W/LGE and in 39/41 cases (95%) by mapping techniques (p < 0.001), was more common in patients with complicated AM. In the 41 patients undergoing both evaluations, CMR sensitivity for myocarditis was 85% for the classic LLC vs. 100% for the updated LLC (p = 0.006)., Conclusion: In patients with myocarditis on RVS-EMB, CMR using updated LLC has high sensitivity in the detection of AM when performed within 30 days. Septal abnormalities are more common in patients with complicated AM., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
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- 2023
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47. Toward a One-Stop Shop CT Protocol in Acute Chest Pain Syndrome.
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Vignale D, Palmisano A, Colantoni C, Brunetti L, Nicoletti V, Gnasso C, and Esposito A
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- Humans, Syndrome, Chest Pain, Tomography, X-Ray Computed methods
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- 2023
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48. Cardiac magnetic resonance in systemic sclerosis myocarditis: the value of T2 mapping to detect myocardial inflammation.
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De Luca G, Palmisano A, Campochiaro C, Vignale D, Cavalli G, Bruno E, Sartorelli S, Ferlito A, Peretto G, Sala S, Matucci-Cerinic M, Dagna L, and Esposito A
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- Female, Humans, Middle Aged, Contrast Media, Gadolinium, Predictive Value of Tests, Magnetic Resonance Spectroscopy, Inflammation, Myocarditis, Scleroderma, Systemic
- Abstract
Objectives: Myocarditis in SSc is associated with a poor prognosis. Cardiac magnetic resonance (CMR) is the non-invasive diagnostic modality of choice for SSc myocarditis. Our study investigates the performance of the mapping techniques included in the revised Lake Louise criteria (LLC) for the identification of SSc myocarditis., Methods: CMR data (right and left ventricular function and morphology, early and late gadolinium enhancement [LGE], T2 ratio, and T1 mapping, extracellular volume [ECV] and T2 mapping) of SSc patients diagnosed with myocarditis were reviewed. Myocarditis was defined by the presence of symptoms of SSc heart involvement with increased high-sensitive troponin T (hs-TnT) and/or NT-proBNP and at least an abnormality at 24 h ECG Holter and/or echocardiography and/or CMR. A P-value < 0.05 was considered as statistically significant., Results: Nineteen patients (median age 54 [46-70] years; females 78.9%; diffuse SSc 52.6%; anti-Scl70+ 52.6%) were identified: 11 (57.9%) had echocardiographic, and 8 (42.8%) 24 h ECG Holter abnormalities. All patients had at least one CMR abnormality: LGE in 18 (94.7%), increased ECV in 10 (52.6%) and T2 mapping >50 ms in 15 (78.9%). Median T1 and T2 mapping were 1085 [1069-1110] ms and 53.1 [52-54] ms, respectively. T1 mapping directly correlated with NT-proBNP (r = 0.620; P = 0.005), ESR (r = 0.601; P = 0.008), CRP (r = 0.685; P = 0.001) and skin score (r = 0.507; P = 0.027); ECV correlated with NT-proBNP serum levels (r = 0.702; P = 0.001). No correlations emerged between T2 mapping and other parameters. Ten patients satisfied the 2009 LLC, 17 the 2018 LLC. With the new criteria including T2 mapping, the sensitivity improved from 52.6% to 89.5%., Conclusion: The CMR mapping techniques improve the sensitivity to detect myocardial inflammation in patients with SSc heart involvement. The evaluation of T2 mapping increases diagnostic accuracy for the recognition of myocardial inflammation in SSc., (© The Author(s) 2022. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2022
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49. Exercise Stress Test Late after Arrhythmic versus Nonarrhythmic Presentation of Myocarditis.
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Peretto G, Gulletta S, Slavich M, Campochiaro C, Vignale D, De Luca G, Palmisano A, Villatore A, Rizzo S, Cavalli G, De Gaspari M, Busnardo E, Gianolli L, Dagna L, Basso C, Esposito A, Sala S, Della Bella P, and Mazzone P
- Abstract
Background. Exercise stress test (EST) has been scarcely investigated in patients with arrhythmic myocarditis. Objectives. To report the results of EST late after myocarditis with arrhythmic vs. nonarrhythmic presentation. Methods. We enrolled consecutive adult patients with EST performed at least six months after acute myocarditis was diagnosed using gold-standard techniques. Patients with ventricular arrhythmia (VA) at presentation were compared with the nonarrhythmic group. Adverse events occurring during follow-up after EST included cardiac death, disease-related rehospitalization, malignant VA, and proven active myocarditis. Results. The study cohort was composed of 128 patients (age 41 ± 9 y, 70% males) undergoing EST after myocarditis. Of them, 64 (50%) had arrhythmic presentation. EST was performed after 15 ± 4 months from initial diagnosis, and was conducted on betablockers in 75 cases (59%). During EST, VA were more common in the arrhythmic group (43 vs. 4, p < 0.001), whereas signs and symptoms of ischemia were more prevalent in the nonarrhythmic one (6 vs. 1, p = 0.115). By 58-month mean follow-up, 52 patients (41%) experienced adverse events, with a greater prevalence among arrhythmic patients (39 vs. 13, p < 0.001). As documented both in the arrhythmic and nonarrhythmic subgroups, patients had greater prevalence of adverse events following a positive EST (40/54 vs. 12/74 with negative EST, p < 0.001). Electrocardiographic features of VA during EST correlated with the subsequent inflammatory restaging of myocarditis. Nonarrhythmic patients with uneventful EST both on- and off-treatment were free from subsequent adverse events. Conclusions. Late after the arrhythmic presentation of myocarditis, EST was frequently associated with recurrent VA. In both arrhythmic and nonarrhythmic myocarditis, EST abnormalities correlated with subsequent adverse outcomes.
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- 2022
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50. Clinical Applications of FDG-PET Scan in Arrhythmic Myocarditis.
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Peretto G, Busnardo E, Ferro P, Palmisano A, Vignale D, Esposito A, De Luca G, Campochiaro C, Sartorelli S, De Gaspari M, Rizzo S, Dagna L, Basso C, Gianolli L, Della Bella P, and Sala S
- Subjects
- Adult, Female, Fluorodeoxyglucose F18, Humans, Male, Middle Aged, Positron-Emission Tomography methods, Predictive Value of Tests, Radiopharmaceuticals, Myocarditis complications, Myocarditis diagnostic imaging, Myocarditis therapy, Sarcoidosis complications, Sarcoidosis diagnostic imaging, Sarcoidosis therapy
- Abstract
Background:
18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) scan has no recognized role in diagnosis, prognosis, and disease monitoring in patients with arrhythmic myocarditis., Objectives: The purpose of this study was to investigate the value of FDG-PET scan in arrhythmic myocarditis., Methods: The authors enrolled 75 consecutive patients (age 47 ± 14 years, 65% men) undergoing FDG-PET scan for arrhythmic myocarditis. Myocarditis was diagnosed by endomyocardial biopsy (EMB) and, whenever applicable, cardiac magnetic resonance (CMR)., Results: Indications for FDG-PET scan included either contraindication to CMR (n = 50) or mismatch between CMR and EMB (n = 25). Overall, 50 patients (67%) had positive FDG-PET. Sensitivity was 75% referring to EMB, and 73% to CMR. Specificity was 67% referring to EMB, and 59% to CMR. FDG-PET accuracy was lower in the presence of borderline myocarditis, and either late (>30 days) or on-immunosuppression FDG-PET scanning. Anteroseptal distribution pattern, found in 12 of 50 (24%) patients including 7 of 7 cardiac sarcoidosis cases, was associated with greater occurrence of ventricular arrhythmias and atrioventricular blocks in 4.2 ± 1.7 years of follow-up (10 of 12 vs 7 of 38, and 7 of 12 vs 0 of 38, respectively; both P < 0.001). In 39 patients (52%), FDG-PET was repeated by 13 ± 2 months, allowing immunosuppression withdrawal after FDG uptake normalization either by first (76%) or second reassessment (24%)., Conclusions: FDG-PET scan may be a clinically useful diagnostic technique in arrhythmic myocarditis, in particular when CMR is unsuitable because of irregular heartbeat or implantable cardioverter-defibrillator-related artifacts. Anteroseptal FDG distribution is associated with a worse arrhythmic outcome and should raise the suspicion of cardiac sarcoidosis. During follow-up, repeated FDG-PET allows myocarditis monitoring to guide immunosuppression withdrawal., Competing Interests: Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)- Published
- 2022
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