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Your search keyword '"Viéro, Cédric"' showing total 18 results
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18 results on '"Viéro, Cédric"'

11. Management of Cytokine Release Syndrome in AML Patients Treated with Flotetuzumab, a CD123 x CD3 Bispecific Dart® Molecule for T-Cell Redirected Therapy

Author

Jacobs, Kenneth, Viero, Cedric, Godwin, John, Baughman, Jan, Sun, Jichao, Ying, Kang, Muth, John, Hong, Shengyan, Vey, Norbert, Sweet, Kendra L., Uy, Geoffrey L., Ravandi, Farhad, Foster, Matthew C, Rizzieri, David A., Arellano, Martha L., Rettig, Michael P., Topp, Max S., Huls, Gerwin, Lelièvre, Helene, Paolini, Stefania, Ciceri, Fabio, Carrabba, Matteo Giovanni, Lowenberg, Bob, DiPersio, John F., Wigginton, Jon, and Davidson-Moncada, Jan K

Published
2018
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16. Rapid inhibition of Ca2+ influx by neurosteroids in murine embryonic sensory neurones.

Author

Viéro, Cédric, Méchaly, Ilana, Aptel, Hervé, Puech, Sylvie, Valmier, Jean, Bancel, Frédéric, and Dayanithi, G.

Subjects
STEROIDS, NEURONS, GABA, PROGESTERONE, RESEARCH
Abstract

Abstract: The non-genomic role of neuroactive steroids on [Ca2+]i transients induced by GABA receptor activation was investigated in cultured dorsal root ganglia (DRG) neurones at embryonic stage E13. [Ca2+]i measurements were performed with Fura-2 fast fluorescence microfluorimetry. Application of the GABAA receptor agonist muscimol (Musci) evoked an increase in [Ca2+]i, confirming the excitatory effect of GABA at this embryonic stage. The muscimol-induced [Ca2+]i response was inhibited by progesterone (Proges) and its primary metabolite allopregnanolone (Allo) in a rapid, reversible and dose-dependent manner. These calcium transients were suppressed in the absence of external Ca2+ or in the presence of Ni2+ +Cd2+ suggesting an involvement of voltage-activated Ca2+ channels. In contrast, none of these steroids affected the resting [Ca2+]i nor exhibited any inhibitory effect on 50mM KCl-induced [Ca2+]i increases. In view of the well-established potentiation of GABAA receptor by direct binding of neurosteroids, the inhibitory effects described in this study seem to involve distinct mechanisms. This new inhibitory effect of progesterone is observed at low and physiological concentrations, is rapid and independent of RU38486, an antagonist of the classic progesterone receptor, probably involving a membrane receptor. Using RT-PCR, we demonstrated the expression of progesterone receptor membrane component 1 (Pgrmc1), encoding 25-Dx, a membrane-associated progesterone binding protein in DRG neurones at different stages of development. In conclusion, we describe for the first time a rapid effect of progestins on embryonic DRG neurones involving an antagonistic effect of progesterone and allopregnanolone on GABAA receptors. [Copyright &y& Elsevier]

Published
2006
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