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1. Percutaneous or surgical management of post-infarction ventricular septal defects: The United Kingdom National Registry

Author

Giblett, JP, Matetic, A, Jenkins, D, Ng, CY, Venuraju, S, MacCarthy, T, Vibhishanan, J, O’Neill, JP, Kirmani, BH, Pullan, DM, Stables, RH, Andrews, J, Nicolas, B, Kim, WC, Kanyal, R, Butler, MA, Butler, R, George, S, Khurana, A, Crossland, DS, Marczak, J, Smith, WHT, Thomson, JDR, Bentham, JR, Clapp, BR, Buch, M, Hayes, N, Byrne, J, MacCarthy, P, Aggarwal, SK, Shapiro, LM, Turner, MS, de Giovanni, J, Northridge, DB, Hildick-Smith, D, Mamas, M, and Calvert, PA

Subjects
RD32, R735, R1, RD
Abstract

Background and Aims Postinfarction ventricular septal defect (PIVSD) is a mechanical complication of myocardial infarction (MI) with a poor prognosis. Surgical repair is the mainstay of treatment, although percutaneous closure is increasingly undertaken. Methods Patients treated with surgical or percutaneous repair of PIVSD (2010-2021) were identified at 16 UK centres. Case note review was undertaken. The primary outcome was long-term mortality. Patient groups were allocated based upon initial management (percutaneous or surgical). Results 362 patients received 416 procedures (131 percutaneous, 231 surgery). 16.1% of percutaneous patients subsequently had surgery. 7.8% of surgical patients subsequently had percutaneous treatment. Times from MI to treatment were the similar (percutaneous 9[6-14] vs. surgical 9[4-22] days, p=0.18). Surgical patients were more likely to have cardiogenic shock (62.8% vs. 51.9, p=0.044). Percutaneous patients were substantially older (72 [64-77] vs. 67[61-73] years, p

Published
2022

4. Poster Session 2 : Monday 4 May 2015, 08

Author

Bouyoucef, S E, Uusitalo, V, Kamperidis, V, De Graaf, M A, Maaniitty, T, Stenstrom, I, Broersen, A, Scholte, A J, Saraste, A, Bax, J J, Knuuti, J, Furuhashi, T, Moroi, M, Awaya, T, Masai, H, Minakawa, M, Kunimasa, T, Fukuda, H, Sugi, K, Berezin, A, Kremzer, A, Clerc, O F, Kaufmann, B, Possner, M, Liga, R, Vontobel, J, Mikulicic, F, Graeni, C, Benz, D C, Kaufmann, P A, Buechel, R B, Ferreira, Mjv, Cunha, M J, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peix, A, Cisneros, L, Cabrera, L O, Padron, K, Rodriguez, L, Heres, F, Carrillo, R, Mena, E, Fernandez, Y, Huizing, E D, Van Dijk, J D, Van Dalen, J A, Timmer, J R, Ottervanger, J P, Slump, C H, Jager, P L, Venuraju, S, Jeevarethinam, A, Yerramasu, A, Atwal, S, Mehta, V S, Lahiri, A, Arjonilla Lopez, A, Calero Rueda, M J, Gallardo, G, Fernandez-Cuadrado, J, Hernandez Aceituno, D, Sanchez Hernandez, J, Yoshida, H, Mizukami, A, Matsumura, A, Smettei, O, Abazid, R, Sayed, S, Mlynarska, A, Mlynarski, R, Golba, K, Sosnowski, M, Winther, S, Svensson, M, Jorgensen, H S, Bouchelouche, K, Gormsen, L C, Holm, N R, Botker, H E, Ivarsen, P R, Bottcher, M, Cortes, C M, Aramayo G, E N, Daicz, M, Casuscelli, J F, Alaguibe, E D, Neira Sepulveda, A, Cerda, M, Ganum, G E, Embon, M, Vigne, J, Enilorac, B, Lebasnier, A, Valancogne, L, Peyronnet, D, Manrique, A, Agostini, D, Menendez, D, Rajpal, S, Kocherla, C, Acharya, M, Reddy, P, Sazonova, I, Ilushenkova, Yun, Batalov, R E, Rogovskaya, Y V, Lishmanov, Y B, Popov, S V, Varlamova, N V, Prado Diaz, S, Jimenez Rubio, C, Gemma, D, Refoyo Salicio, E, Valbuena Lopez, S C, Moreno Yanguela, M, Torres, M, Fernandez-Velilla, M, Lopez-Sendon, J L, Guzman Martinez, G, Puente, A, Rosales, S, Martinez, C, Cabada, M, Melendez, G M, Ferreira, R, Gonzaga, A, Santos, J, Vijayan, S, Smith, Smg, Smith, M, Muthusamy, R, Takeishi, Y, Oikawa, M, Goral, J L, Napoli, J, Montana, O R, Damico, A C, Quiroz, M C, Damico, A E, Forcada, P J, Schmidberg, J M, Zucchiatti, N E, Olivieri, D B, Dumo, A, Ruano, S, Rakhit, R, Davar, J, Nair, D, Cohen, M, Darko, D, Yokota, S, Maas, Ahe, Mouden, M, Knollema, S, Sanja Mazic, S M, Lazovic, B, Marina Djelic, Mdj, Jelena Suzic Lazic, J S, Tijana Acimovic, T A, Milica Deleva, M D, Vesnina, Z H, Zafrir, N, Bental, T, Mats, I, Solodky, A, Gutstein, A, Hasid, Y, Belzer, D, Kornowski, R, Ben Said, Rim, Ben Mansour, N, Ibn Haj Amor, H, Chourabi, C, Hagui, A, Fehri, W, Hawala, H, Shugushev, Z, Patrikeev, A, Maximkin, D, Chepurnoy, A, Kallianpur, V, Mambetov, A, Dokshokov, G, Teresinska, A, Wozniak, O, Maciag, A, Wnuk, J, Dabrowski, A, Czerwiec, A, Jezierski, J, Biernacka, K, Robinson, J, Prosser, J, Cheung, Gsm, Allan, S, Mcmaster, G, Reid, S, Tarbuck, A, Martin, W, Queiroz, R C, Falcao, A, Giorgi, McP, Imada, R, Nogueira, S A, Chalela, W A, Kalil Filho, R, Meneghetti, W A, Matveev, V V, Bubyenov, A S, Podzolkov, V I, Baranovich, V, Faibushevich, A, Kolzhecova, Y, Volkova, O, Fernandez, J, Lopez, G, Dondi, M, Paez, D, Butcher, Cjt, Reyes, E, Al-Housni, M B, Green, R, Santiago, H, Ghiotto, F, Hinton-Taylor, S, Pottle, A, Mason, M, Underwood, S R, Casans Tormo, I, Diaz-Exposito, R, Plancha-Burguera, E, Elsaban, K, Alsakhri, Hijji, Yoshinaga, K, Ochi, N, Tomiyama, Y, Katoh, C, Inoue, M, Nishida, M, Suzuki, E, Manabe, O, Ito, Y M, Tamaki, N, Tahilyani, A, Jafary, Fahim, Ho Hee Hwa, H H, Ozdemir, S, Kirilmaz, B, Barutcu, A, Tan, Y Z, Celik, F, Sakgoz, S, Cabada Gamboa, M, Puente Barragan, A, Morales Vitorino, N, Medina Servin, M A, Hindorf, C, Akil, S, Hedeer, F, Jogi, J, Engblom, H, Martire, V D, Pis Diez, E R, Martire, M V, Portillo, D O, Hoff, C M, Balche, A, Majgaard, J, Tolbod, L P, Harms, H J, Soerensen, J, Froekiaer, J, Nudi, F, Neri, G, Procaccini, E, Pinto, A, Vetere, M, Biondi-Zoccai, G, Soares, J, Do Val, R, Oliveira, M A, Meneghetti, J C, Tekabe, Y, Anthony, T, Li, Q, Schmidt, A M, Johnson, L, Groenman, M, Tarkia, M, Kakela, M, Halonen, P, Kiviniemi, T, Pietila, M, Yla-Herttuala, S, Roivainen, A, Nekolla, S, Swirzek, S, Higuchi, T, Reder, S, Schachoff, S, Bschorner, M, Laitinen, I, Robinson, S, Yousefi, B, Schwaiger, M, Kero, Tanja, Lindsjo, L, Antoni, Gunnar, Westermark, P, Carlson, K, Wikstrom, G, Sörensen, Jens, Lubberink, Mark, Rouzet, F, Cognet, T, Guedj, K, Morvan, M, El Shoukr, F, Louedec, L, Choqueux, C, Nicoletti, A, Le Guludec, D, Jimenez-Heffernan, A, Munoz-Beamud, F, Sanchez De Mora, E, Borrachero, C, Salgado, C, Ramos-Font, C, Lopez-Martin, J, Hidalgo, M L, Lopez-Aguilar, R, Soriano, E, Okizaki, A, Nakayama, M, Ishitoya, S, Sato, J, Takahashi, K, Burchert, I, Caobelli, F, Wollenweber, T, Nierada, M, Fulsche, J, Dieckmann, C, Bengel, F M, Shuaib, S, Mahlum, D, Port, S, Refoyo, E, Cuesta, E, Guzman, G, Lopez, T, Valbuena, S, Del Prado, S, Moreno, M, Harbinson, M, Donnelly, L, Einstein, A J, Johnson, L L, Deluca, A J, Kontak, A C, Groves, D W, Stant, J, Pozniakoff, T, Cheng, B, Rabbani, L E, Bokhari, S, Schuetze, C, Aguade-Bruix, S, Pizzi, M N, Romero-Farina, G, Terricabras, M, Villasboas, D, Castell-Conesa, J, Candell-Riera, J, Brunner, S, Gross, L, Todica, A, Lehner, S, Di Palo, A, Niccoli Asabella, A, Magarelli, C, Notaristefano, A, Ferrari, C, Rubini, G, Sellem, A, Melki, S, Elajmi, W, Hammami, H, Ziadi, M C, Montero, J, Ameriso, J L, Villavicencio, R L, Benito Gonzalez, T F, Mayorga Bajo, A, Gutierrez Caro, R, Rodriguez Santamarta, M, Alvarez Roy, L, Martinez Paz, E, Barinaga Martin, C, Martin Fernandez, J, Alonso Rodriguez, D, Iglesias Garriz, I, Rosillo, S, Taleb, S, Cherkaoui Salhi, G, Regbaoui, Y, Ait Idir, M, Guensi, A, Martin Lopez, C E, Castano Ruiz, M, Bouyoucef, S E, Uusitalo, V, Kamperidis, V, De Graaf, M A, Maaniitty, T, Stenstrom, I, Broersen, A, Scholte, A J, Saraste, A, Bax, J J, Knuuti, J, Furuhashi, T, Moroi, M, Awaya, T, Masai, H, Minakawa, M, Kunimasa, T, Fukuda, H, Sugi, K, Berezin, A, Kremzer, A, Clerc, O F, Kaufmann, B, Possner, M, Liga, R, Vontobel, J, Mikulicic, F, Graeni, C, Benz, D C, Kaufmann, P A, Buechel, R B, Ferreira, Mjv, Cunha, M J, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peix, A, Cisneros, L, Cabrera, L O, Padron, K, Rodriguez, L, Heres, F, Carrillo, R, Mena, E, Fernandez, Y, Huizing, E D, Van Dijk, J D, Van Dalen, J A, Timmer, J R, Ottervanger, J P, Slump, C H, Jager, P L, Venuraju, S, Jeevarethinam, A, Yerramasu, A, Atwal, S, Mehta, V S, Lahiri, A, Arjonilla Lopez, A, Calero Rueda, M J, Gallardo, G, Fernandez-Cuadrado, J, Hernandez Aceituno, D, Sanchez Hernandez, J, Yoshida, H, Mizukami, A, Matsumura, A, Smettei, O, Abazid, R, Sayed, S, Mlynarska, A, Mlynarski, R, Golba, K, Sosnowski, M, Winther, S, Svensson, M, Jorgensen, H S, Bouchelouche, K, Gormsen, L C, Holm, N R, Botker, H E, Ivarsen, P R, Bottcher, M, Cortes, C M, Aramayo G, E N, Daicz, M, Casuscelli, J F, Alaguibe, E D, Neira Sepulveda, A, Cerda, M, Ganum, G E, Embon, M, Vigne, J, Enilorac, B, Lebasnier, A, Valancogne, L, Peyronnet, D, Manrique, A, Agostini, D, Menendez, D, Rajpal, S, Kocherla, C, Acharya, M, Reddy, P, Sazonova, I, Ilushenkova, Yun, Batalov, R E, Rogovskaya, Y V, Lishmanov, Y B, Popov, S V, Varlamova, N V, Prado Diaz, S, Jimenez Rubio, C, Gemma, D, Refoyo Salicio, E, Valbuena Lopez, S C, Moreno Yanguela, M, Torres, M, Fernandez-Velilla, M, Lopez-Sendon, J L, Guzman Martinez, G, Puente, A, Rosales, S, Martinez, C, Cabada, M, Melendez, G M, Ferreira, R, Gonzaga, A, Santos, J, Vijayan, S, Smith, Smg, Smith, M, Muthusamy, R, Takeishi, Y, Oikawa, M, Goral, J L, Napoli, J, Montana, O R, Damico, A C, Quiroz, M C, Damico, A E, Forcada, P J, Schmidberg, J M, Zucchiatti, N E, Olivieri, D B, Dumo, A, Ruano, S, Rakhit, R, Davar, J, Nair, D, Cohen, M, Darko, D, Yokota, S, Maas, Ahe, Mouden, M, Knollema, S, Sanja Mazic, S M, Lazovic, B, Marina Djelic, Mdj, Jelena Suzic Lazic, J S, Tijana Acimovic, T A, Milica Deleva, M D, Vesnina, Z H, Zafrir, N, Bental, T, Mats, I, Solodky, A, Gutstein, A, Hasid, Y, Belzer, D, Kornowski, R, Ben Said, Rim, Ben Mansour, N, Ibn Haj Amor, H, Chourabi, C, Hagui, A, Fehri, W, Hawala, H, Shugushev, Z, Patrikeev, A, Maximkin, D, Chepurnoy, A, Kallianpur, V, Mambetov, A, Dokshokov, G, Teresinska, A, Wozniak, O, Maciag, A, Wnuk, J, Dabrowski, A, Czerwiec, A, Jezierski, J, Biernacka, K, Robinson, J, Prosser, J, Cheung, Gsm, Allan, S, Mcmaster, G, Reid, S, Tarbuck, A, Martin, W, Queiroz, R C, Falcao, A, Giorgi, McP, Imada, R, Nogueira, S A, Chalela, W A, Kalil Filho, R, Meneghetti, W A, Matveev, V V, Bubyenov, A S, Podzolkov, V I, Baranovich, V, Faibushevich, A, Kolzhecova, Y, Volkova, O, Fernandez, J, Lopez, G, Dondi, M, Paez, D, Butcher, Cjt, Reyes, E, Al-Housni, M B, Green, R, Santiago, H, Ghiotto, F, Hinton-Taylor, S, Pottle, A, Mason, M, Underwood, S R, Casans Tormo, I, Diaz-Exposito, R, Plancha-Burguera, E, Elsaban, K, Alsakhri, Hijji, Yoshinaga, K, Ochi, N, Tomiyama, Y, Katoh, C, Inoue, M, Nishida, M, Suzuki, E, Manabe, O, Ito, Y M, Tamaki, N, Tahilyani, A, Jafary, Fahim, Ho Hee Hwa, H H, Ozdemir, S, Kirilmaz, B, Barutcu, A, Tan, Y Z, Celik, F, Sakgoz, S, Cabada Gamboa, M, Puente Barragan, A, Morales Vitorino, N, Medina Servin, M A, Hindorf, C, Akil, S, Hedeer, F, Jogi, J, Engblom, H, Martire, V D, Pis Diez, E R, Martire, M V, Portillo, D O, Hoff, C M, Balche, A, Majgaard, J, Tolbod, L P, Harms, H J, Soerensen, J, Froekiaer, J, Nudi, F, Neri, G, Procaccini, E, Pinto, A, Vetere, M, Biondi-Zoccai, G, Soares, J, Do Val, R, Oliveira, M A, Meneghetti, J C, Tekabe, Y, Anthony, T, Li, Q, Schmidt, A M, Johnson, L, Groenman, M, Tarkia, M, Kakela, M, Halonen, P, Kiviniemi, T, Pietila, M, Yla-Herttuala, S, Roivainen, A, Nekolla, S, Swirzek, S, Higuchi, T, Reder, S, Schachoff, S, Bschorner, M, Laitinen, I, Robinson, S, Yousefi, B, Schwaiger, M, Kero, Tanja, Lindsjo, L, Antoni, Gunnar, Westermark, P, Carlson, K, Wikstrom, G, Sörensen, Jens, Lubberink, Mark, Rouzet, F, Cognet, T, Guedj, K, Morvan, M, El Shoukr, F, Louedec, L, Choqueux, C, Nicoletti, A, Le Guludec, D, Jimenez-Heffernan, A, Munoz-Beamud, F, Sanchez De Mora, E, Borrachero, C, Salgado, C, Ramos-Font, C, Lopez-Martin, J, Hidalgo, M L, Lopez-Aguilar, R, Soriano, E, Okizaki, A, Nakayama, M, Ishitoya, S, Sato, J, Takahashi, K, Burchert, I, Caobelli, F, Wollenweber, T, Nierada, M, Fulsche, J, Dieckmann, C, Bengel, F M, Shuaib, S, Mahlum, D, Port, S, Refoyo, E, Cuesta, E, Guzman, G, Lopez, T, Valbuena, S, Del Prado, S, Moreno, M, Harbinson, M, Donnelly, L, Einstein, A J, Johnson, L L, Deluca, A J, Kontak, A C, Groves, D W, Stant, J, Pozniakoff, T, Cheng, B, Rabbani, L E, Bokhari, S, Schuetze, C, Aguade-Bruix, S, Pizzi, M N, Romero-Farina, G, Terricabras, M, Villasboas, D, Castell-Conesa, J, Candell-Riera, J, Brunner, S, Gross, L, Todica, A, Lehner, S, Di Palo, A, Niccoli Asabella, A, Magarelli, C, Notaristefano, A, Ferrari, C, Rubini, G, Sellem, A, Melki, S, Elajmi, W, Hammami, H, Ziadi, M C, Montero, J, Ameriso, J L, Villavicencio, R L, Benito Gonzalez, T F, Mayorga Bajo, A, Gutierrez Caro, R, Rodriguez Santamarta, M, Alvarez Roy, L, Martinez Paz, E, Barinaga Martin, C, Martin Fernandez, J, Alonso Rodriguez, D, Iglesias Garriz, I, Rosillo, S, Taleb, S, Cherkaoui Salhi, G, Regbaoui, Y, Ait Idir, M, Guensi, A, Martin Lopez, C E, and Castano Ruiz, M

Published
2015
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5. Poster Session 3 : Tuesday 5 May 2015, 08

Author

Ferreira, Mjv, Robalo, M M, Saraiva, T, Cunha, M J, Goncalves, L, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peovska, I, Davceva Pavlovska, J, Pop Gorceva, D, Zdravkovska, M, Vavlukis, M, Kostova, N, Bulugahapitiya, D S, Feben, A, Avison, M, Foley, J, Martin, J, De Graaf, M A, Van Den Hoogen, I J, Leen, A C, Kharagjitsingh, A V, Kroft, L J, Jukema, J W, Bax, J J, Scholte, A J, Patel, K, Mahan, M, Ananthasubramaniam, K, Durmus Altun, G, Alpay, M, Altun, A, Andreini, D, Pontone, G, Mushtaq, S, Bertella, E, Conte, E, Segurini, C, Volpato, V, Petulla, M, Baggiano, A, Pepi, M, Van Dijk, J D, Huizing, E D, Jager, P L, Slump, C H, Ottervanger, J P, Van Dalen, J A, Yambao, E, Calleja, H B, Sibulo, A S, Ramirez Moreno, A, Siles Rubio, J R, Noureddine, M, Munoz-Bellido, J, Bravo, R, Martinez, F, Valle, A, Milan, A, Inigo-Garcia, L, Velasco, T, Ramaiah, V L, Devanbu, J S, Taywade, S K, Hejjaji, V S, Zafrir, N, Bental, T, Gutstein, A, Solodky, A, Mats, I, Kornowski, R, Lagan, J, Hasleton, J, Meah, M, Mcshane, J, Trent, R, Massalha, S, Israel, O, Koskosi, A, Kopelovich, M, Marai, I, Venuraju, S, Jeevarethinam, A, Dumo, A, Ruano, S, Darko, D, Cohen, M, Nair, D, Rosenthal, M, Rakhit, R, Lahiri, A, Pizzi, M N, Roque, A, Fernandez-Hidalgo, N, Cuellar-Calabria, H, Gonzalez-Alujas, M T, Oristrell, G, Rodriguez-Palomares, J, Tornos, P, Aguade-Bruix, S, Smettei, O, Abazid, R, Ahmed, W M K, Samy, W, Behairy, N, Tayeh, O, Hassan, A, Berezin, A, Kremzer, A, Samura, T, Berezina, T, Scrima, G, Bertuccio, G, Canseco Nadia, Ncl, Cruz Raul, C R, Gonzalez Cristian, G C, Hernandez Salvador, S H, Alexanderson Erick, Ear, Zerahn, B, Shugushev, Z, Maximkin, D, Chepurnoy, A, Volkova, O, Tsedenova, A, Faibushevich, A, Baranovich, V, Yoshida, H, Mizukami, A, Matsumura, A, Keller, M, Silber, S, Falcao, A, Imada, R, Azouri, L O, Giorgi, McP, Santos, R D, Mello, S L, Kalil Filho, R, Meneghetti, J C, Chalela, W A, Kanni, L, Ohrman, T, Nygren, A T, Irabi, R D, Parisotto, T, Soares, J, Burrell, S, Lo, C, Zavadovskyi, K, Gulya, M, Lishmanov, Y U, Amin, A, Kandeel, Ahmed, Shaban, Mahmud, Nawito, Zeinab, Caobelli, F, Soffientini, A, Thackeray, J T, Bengel, F M, Pizzocaro, C, Guerra, U P, Hellberg, S E, Silvola, Jmu, Kiugel, M, Liljenback, H, Savisto, N, Thiele, A, Laine, Vjo, Knuuti, J, Roivainen, A, Saraste, A, Ismail, B, Hadizad, T, Dekemp, Rob, Beanlands, Rob, Dasilva, J N, Hyafil, F, Sorbets, E, Duchatelle, V, Rouzet, F, Le Guludec, D, Feldman, L, Martire, V D, De Pierris, C, Martire, M V, Pis Diez, E R, Ramaiah, V, Lebasnier, A, Legallois, D, Peyronnet, D, Desmonts, C, Zalcman, G, Bienvenu, B, Agostini, D, Manrique, A, Solomyanyy, V, Mintale, I, Zabunova, M, Narbute, I, Ratniece, M, Jakobsons, E, Kaire, K, Kamzola, G, Briede, I, Jegere, S, Erglis, A, Mostafa, S, Abdelkader, M, Abdelkader, H, Abdelkhlek, S, Khairy, E, Huidu, S, Popescu, A, Lacau, S, Huidu, A, Dimulescu, D, Sayed, S, Al Harby, F, Habeeb, A, Saqqah, H, Merganiab, S, Selvanayagam, J, Harms, H J, Tolbod, L P, Hansson, N H, Kero, T, Orndahl, L H, Kim, W Y, Bouchelouche, K, Wiggers, H, Frokiaer, J, Sorensen, J, Tolbod, L, Hansen, E, Zaremba, T, Kero, Tanja, Sörensen, Jens, Ferreira, Mjv, Robalo, M M, Saraiva, T, Cunha, M J, Goncalves, L, Albuquerque, A, Ramos, D, Costa, G, Lima, J, Pego, M, Peovska, I, Davceva Pavlovska, J, Pop Gorceva, D, Zdravkovska, M, Vavlukis, M, Kostova, N, Bulugahapitiya, D S, Feben, A, Avison, M, Foley, J, Martin, J, De Graaf, M A, Van Den Hoogen, I J, Leen, A C, Kharagjitsingh, A V, Kroft, L J, Jukema, J W, Bax, J J, Scholte, A J, Patel, K, Mahan, M, Ananthasubramaniam, K, Durmus Altun, G, Alpay, M, Altun, A, Andreini, D, Pontone, G, Mushtaq, S, Bertella, E, Conte, E, Segurini, C, Volpato, V, Petulla, M, Baggiano, A, Pepi, M, Van Dijk, J D, Huizing, E D, Jager, P L, Slump, C H, Ottervanger, J P, Van Dalen, J A, Yambao, E, Calleja, H B, Sibulo, A S, Ramirez Moreno, A, Siles Rubio, J R, Noureddine, M, Munoz-Bellido, J, Bravo, R, Martinez, F, Valle, A, Milan, A, Inigo-Garcia, L, Velasco, T, Ramaiah, V L, Devanbu, J S, Taywade, S K, Hejjaji, V S, Zafrir, N, Bental, T, Gutstein, A, Solodky, A, Mats, I, Kornowski, R, Lagan, J, Hasleton, J, Meah, M, Mcshane, J, Trent, R, Massalha, S, Israel, O, Koskosi, A, Kopelovich, M, Marai, I, Venuraju, S, Jeevarethinam, A, Dumo, A, Ruano, S, Darko, D, Cohen, M, Nair, D, Rosenthal, M, Rakhit, R, Lahiri, A, Pizzi, M N, Roque, A, Fernandez-Hidalgo, N, Cuellar-Calabria, H, Gonzalez-Alujas, M T, Oristrell, G, Rodriguez-Palomares, J, Tornos, P, Aguade-Bruix, S, Smettei, O, Abazid, R, Ahmed, W M K, Samy, W, Behairy, N, Tayeh, O, Hassan, A, Berezin, A, Kremzer, A, Samura, T, Berezina, T, Scrima, G, Bertuccio, G, Canseco Nadia, Ncl, Cruz Raul, C R, Gonzalez Cristian, G C, Hernandez Salvador, S H, Alexanderson Erick, Ear, Zerahn, B, Shugushev, Z, Maximkin, D, Chepurnoy, A, Volkova, O, Tsedenova, A, Faibushevich, A, Baranovich, V, Yoshida, H, Mizukami, A, Matsumura, A, Keller, M, Silber, S, Falcao, A, Imada, R, Azouri, L O, Giorgi, McP, Santos, R D, Mello, S L, Kalil Filho, R, Meneghetti, J C, Chalela, W A, Kanni, L, Ohrman, T, Nygren, A T, Irabi, R D, Parisotto, T, Soares, J, Burrell, S, Lo, C, Zavadovskyi, K, Gulya, M, Lishmanov, Y U, Amin, A, Kandeel, Ahmed, Shaban, Mahmud, Nawito, Zeinab, Caobelli, F, Soffientini, A, Thackeray, J T, Bengel, F M, Pizzocaro, C, Guerra, U P, Hellberg, S E, Silvola, Jmu, Kiugel, M, Liljenback, H, Savisto, N, Thiele, A, Laine, Vjo, Knuuti, J, Roivainen, A, Saraste, A, Ismail, B, Hadizad, T, Dekemp, Rob, Beanlands, Rob, Dasilva, J N, Hyafil, F, Sorbets, E, Duchatelle, V, Rouzet, F, Le Guludec, D, Feldman, L, Martire, V D, De Pierris, C, Martire, M V, Pis Diez, E R, Ramaiah, V, Lebasnier, A, Legallois, D, Peyronnet, D, Desmonts, C, Zalcman, G, Bienvenu, B, Agostini, D, Manrique, A, Solomyanyy, V, Mintale, I, Zabunova, M, Narbute, I, Ratniece, M, Jakobsons, E, Kaire, K, Kamzola, G, Briede, I, Jegere, S, Erglis, A, Mostafa, S, Abdelkader, M, Abdelkader, H, Abdelkhlek, S, Khairy, E, Huidu, S, Popescu, A, Lacau, S, Huidu, A, Dimulescu, D, Sayed, S, Al Harby, F, Habeeb, A, Saqqah, H, Merganiab, S, Selvanayagam, J, Harms, H J, Tolbod, L P, Hansson, N H, Kero, T, Orndahl, L H, Kim, W Y, Bouchelouche, K, Wiggers, H, Frokiaer, J, Sorensen, J, Tolbod, L, Hansen, E, Zaremba, T, Kero, Tanja, and Sörensen, Jens

Published
2015
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6. Poster Session 3: Tuesday 5 May 2015, 08:30-12:30 * Room: Poster Area

Author

Ferreira, M., primary, Robalo, M., additional, Saraiva, T., additional, Cunha, M., additional, Goncalves, L., additional, Albuquerque, A., additional, Ramos, D., additional, Costa, G., additional, Lima, J., additional, Pego, M., additional, Peovska, I., additional, Davceva Pavlovska, J., additional, Pop Gorceva, D., additional, Zdravkovska, M., additional, Vavlukis, M., additional, Kostova, N., additional, Bulugahapitiya, D. S., additional, Feben, A., additional, Avison, M., additional, Foley, J., additional, Martin, J., additional, De Graaf, M. A., additional, Van Den Hoogen, I., additional, Leen, A., additional, Kharagjitsingh, A., additional, Kroft, L., additional, Jukema, J., additional, Bax, J., additional, Scholte, A., additional, Patel, K., additional, Mahan, M., additional, Ananthasubramaniam, K., additional, Durmus Altun, G., additional, Alpay, M., additional, Altun, A., additional, Andreini, D., additional, Pontone, G., additional, Mushtaq, S., additional, Bertella, E., additional, Conte, E., additional, Segurini, C., additional, Volpato, V., additional, Petulla, M., additional, Baggiano, A., additional, Pepi, M., additional, Van Dijk, J., additional, Huizing, E., additional, Jager, P., additional, Slump, C., additional, Ottervanger, J., additional, Van Dalen, J., additional, Yambao, E., additional, Calleja, H., additional, Sibulo, A., additional, Ramirez Moreno, A., additional, Siles Rubio, J., additional, Noureddine, M., additional, Munoz-Bellido, J., additional, Bravo, R., additional, Martinez, F., additional, Valle, A., additional, Milan, A., additional, Inigo-Garcia, L., additional, Velasco, T., additional, Ramaiah, V. L., additional, Devanbu, J. S., additional, Taywade, S. K., additional, Hejjaji, V. S., additional, Zafrir, N., additional, Bental, T., additional, Gutstein, A., additional, Solodky, A., additional, Mats, I., additional, Kornowski, R., additional, Lagan, J., additional, Hasleton, J., additional, Meah, M., additional, Mcshane, J., additional, Trent, R., additional, Massalha, S., additional, Israel, O., additional, Koskosi, A., additional, Kopelovich, M., additional, Marai, I., additional, Venuraju, S., additional, Jeevarethinam, A., additional, Dumo, A., additional, Ruano, S., additional, Darko, D., additional, Cohen, M., additional, Nair, D., additional, Rosenthal, M., additional, Rakhit, R., additional, Lahiri, A., additional, Pizzi, M. N., additional, Roque, A., additional, Fernandez-Hidalgo, N., additional, Cuellar-Calabria, H., additional, Gonzalez-Alujas, M., additional, Oristrell, G., additional, Rodriguez-Palomares, J., additional, Tornos, P., additional, Aguade-Bruix, S., additional, Smettei, O., additional, Abazid, R., additional, Ahmed, W. M. K., additional, Samy, W., additional, Behairy, N., additional, Tayeh, O., additional, Hassan, A., additional, Berezin, A., additional, Kremzer, A., additional, Samura, T., additional, Berezina, T., additional, Scrima, G., additional, Bertuccio, G., additional, Canseco Nadia, N., additional, Cruz Raul, C., additional, Gonzalez Cristian, G., additional, Hernandez Salvador, S., additional, Alexanderson Erick, E., additional, Zerahn, B., additional, Shugushev, Z., additional, Maximkin, D., additional, Chepurnoy, A., additional, Volkova, O., additional, Tsedenova, A., additional, Faibushevich, A., additional, Baranovich, V., additional, Yoshida, H., additional, Mizukami, A., additional, Matsumura, A., additional, Keller, M., additional, Silber, S., additional, Falcao, A., additional, Imada, R., additional, Azouri, L., additional, Giorgi, M., additional, Santos, R., additional, Mello, S., additional, Kalil Filho, R., additional, Meneghetti, J., additional, Chalela, W., additional, Kanni, L., additional, Ohrman, T., additional, Nygren, A. T., additional, Irabi, R., additional, Parisotto, T., additional, Soares, J., additional, Burrell, S., additional, Lo, C., additional, Zavadovskyi, K., additional, Gulya, M., additional, Lishmanov, Y., additional, Amin, A., additional, Kandeel, A., additional, Shaban, M., additional, Nawito, Z., additional, Caobelli, F., additional, Soffientini, A., additional, Thackeray, J., additional, Bengel, F., additional, Pizzocaro, C., additional, Guerra, U., additional, Hellberg, S., additional, Silvola, J., additional, Kiugel, M., additional, Liljenback, H., additional, Savisto, N., additional, Thiele, A., additional, Laine, V., additional, Knuuti, J., additional, Roivainen, A., additional, Saraste, A., additional, Ismail, B., additional, Hadizad, T., additional, Dekemp, R., additional, Beanlands, R., additional, Dasilva, J. N., additional, Hyafil, F., additional, Sorbets, E., additional, Duchatelle, V., additional, Rouzet, F., additional, Le Guludec, D., additional, Feldman, L., additional, Martire, V., additional, De Pierris, C., additional, Martire, M., additional, Pis Diez, E., additional, Ramaiah, V., additional, Lebasnier, A., additional, Legallois, D., additional, Peyronnet, D., additional, Desmonts, C., additional, Zalcman, G., additional, Bienvenu, B., additional, Agostini, D., additional, Manrique, A., additional, Solomyanyy, V., additional, Mintale, I., additional, Zabunova, M., additional, Narbute, I., additional, Ratniece, M., additional, Jakobsons, E., additional, Kaire, K., additional, Kamzola, G., additional, Briede, I., additional, Jegere, S., additional, Erglis, A., additional, Mostafa, S., additional, Abdelkader, M., additional, Abdelkader, H., additional, Abdelkhlek, S., additional, Khairy, E., additional, Huidu, S., additional, Popescu, A., additional, Lacau, S., additional, Huidu, A., additional, Dimulescu, D., additional, Sayed, S., additional, Al Harby, F., additional, Habeeb, A., additional, Saqqah, H., additional, Merganiab, S., additional, Selvanayagam, J., additional, Harms, H., additional, Tolbod, L., additional, Hansson, N., additional, Kero, T., additional, Orndahl, L., additional, Kim, W., additional, Bouchelouche, K., additional, Wiggers, H., additional, Frokiaer, J., additional, Sorensen, J., additional, Hansen, E., additional, and Zaremba, T., additional

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2015
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7. Poster Session 2: Monday 4 May 2015, 08:00-18:00 * Room: Poster Area

Author

Bouyoucef, S. E., primary, Uusitalo, V., additional, Kamperidis, V., additional, De Graaf, M., additional, Maaniitty, T., additional, Stenstrom, I., additional, Broersen, A., additional, Scholte, A., additional, Saraste, A., additional, Bax, J., additional, Knuuti, J., additional, Furuhashi, T., additional, Moroi, M., additional, Awaya, T., additional, Masai, H., additional, Minakawa, M., additional, Kunimasa, T., additional, Fukuda, H., additional, Sugi, K., additional, Berezin, A., additional, Kremzer, A., additional, Clerc, O., additional, Kaufmann, B., additional, Possner, M., additional, Liga, R., additional, Vontobel, J., additional, Mikulicic, F., additional, Graeni, C., additional, Benz, D., additional, Kaufmann, P., additional, Buechel, R., additional, Ferreira, M., additional, Cunha, M., additional, Albuquerque, A., additional, Ramos, D., additional, Costa, G., additional, Lima, J., additional, Pego, M., additional, Peix, A., additional, Cisneros, L., additional, Cabrera, L., additional, Padron, K., additional, Rodriguez, L., additional, Heres, F., additional, Carrillo, R., additional, Mena, E., additional, Fernandez, Y., additional, Huizing, E., additional, Van Dijk, J., additional, Van Dalen, J., additional, Timmer, J., additional, Ottervanger, J., additional, Slump, C., additional, Jager, P., additional, Venuraju, S., additional, Jeevarethinam, A., additional, Yerramasu, A., additional, Atwal, S., additional, Mehta, V., additional, Lahiri, A., additional, Arjonilla Lopez, A., additional, Calero Rueda, M. J., additional, Gallardo, G., additional, Fernandez-Cuadrado, J., additional, Hernandez Aceituno, D., additional, Sanchez Hernandez, J., additional, Yoshida, H., additional, Mizukami, A., additional, Matsumura, A., additional, Smettei, O., additional, Abazid, R., additional, Sayed, S., additional, Mlynarska, A., additional, Mlynarski, R., additional, Golba, K., additional, Sosnowski, M., additional, Winther, S., additional, Svensson, M., additional, Jorgensen, H., additional, Bouchelouche, K., additional, Gormsen, L., additional, Holm, N., additional, Botker, H., additional, Ivarsen, P., additional, Bottcher, M., additional, Cortes, C. M., additional, Aramayo G, E., additional, Daicz, M., additional, Casuscelli, J., additional, Alaguibe, E., additional, Neira Sepulveda, A., additional, Cerda, M., additional, Ganum, G., additional, Embon, M., additional, Vigne, J., additional, Enilorac, B., additional, Lebasnier, A., additional, Valancogne, L., additional, Peyronnet, D., additional, Manrique, A., additional, Agostini, D., additional, Menendez, D., additional, Rajpal, S., additional, Kocherla, C., additional, Acharya, M., additional, Reddy, P., additional, Sazonova, I., additional, Ilushenkova, Y., additional, Batalov, R., additional, Rogovskaya, Y., additional, Lishmanov, Y., additional, Popov, S., additional, Varlamova, N., additional, Prado Diaz, S., additional, Jimenez Rubio, C., additional, Gemma, D., additional, Refoyo Salicio, E., additional, Valbuena Lopez, S., additional, Moreno Yanguela, M., additional, Torres, M., additional, Fernandez-Velilla, M., additional, Lopez-Sendon, J., additional, Guzman Martinez, G., additional, Puente, A., additional, Rosales, S., additional, Martinez, C., additional, Cabada, M., additional, Melendez, G., additional, Ferreira, R., additional, Gonzaga, A., additional, Santos, J., additional, Vijayan, S., additional, Smith, S., additional, Smith, M., additional, Muthusamy, R., additional, Takeishi, Y., additional, Oikawa, M., additional, Goral, J. L., additional, Napoli, J., additional, Montana, O., additional, Damico, A., additional, Quiroz, M., additional, Forcada, P., additional, Schmidberg, J., additional, Zucchiatti, N., additional, Olivieri, D., additional, Dumo, A., additional, Ruano, S., additional, Rakhit, R., additional, Davar, J., additional, Nair, D., additional, Cohen, M., additional, Darko, D., additional, Yokota, S., additional, Maas, A., additional, Mouden, M., additional, Knollema, S., additional, Sanja Mazic, S., additional, Lazovic, B., additional, Marina Djelic, M., additional, Jelena Suzic Lazic, J., additional, Tijana Acimovic, T., additional, Milica Deleva, M., additional, Vesnina, Z., additional, Zafrir, N., additional, Bental, T., additional, Mats, I., additional, Solodky, A., additional, Gutstein, A., additional, Hasid, Y., additional, Belzer, D., additional, Kornowski, R., additional, Ben Said, R., additional, Ben Mansour, N., additional, Ibn Haj Amor, H., additional, Chourabi, C., additional, Hagui, A., additional, Fehri, W., additional, Hawala, H., additional, Shugushev, Z., additional, Patrikeev, A., additional, Maximkin, D., additional, Chepurnoy, A., additional, Kallianpur, V., additional, Mambetov, A., additional, Dokshokov, G., additional, Teresinska, A., additional, Wozniak, O., additional, Maciag, A., additional, Wnuk, J., additional, Dabrowski, A., additional, Czerwiec, A., additional, Jezierski, J., additional, Biernacka, K., additional, Robinson, J., additional, Prosser, J., additional, Cheung, G., additional, Allan, S., additional, Mcmaster, G., additional, Reid, S., additional, Tarbuck, A., additional, Martin, W., additional, Queiroz, R., additional, Falcao, A., additional, Giorgi, M., additional, Imada, R., additional, Nogueira, S., additional, Chalela, W., additional, Kalil Filho, R., additional, Meneghetti, W., additional, Matveev, V., additional, Bubyenov, A., additional, Podzolkov, V., additional, Baranovich, V., additional, Faibushevich, A., additional, Kolzhecova, Y., additional, Volkova, O., additional, Fernandez, J., additional, Lopez, G., additional, Dondi, M., additional, Paez, D., additional, Butcher, C., additional, Reyes, E., additional, Al-Housni, M., additional, Green, R., additional, Santiago, H., additional, Ghiotto, F., additional, Hinton-Taylor, S., additional, Pottle, A., additional, Mason, M., additional, Underwood, S., additional, Casans Tormo, I., additional, Diaz-Exposito, R., additional, Plancha-Burguera, E., additional, Elsaban, K., additional, Alsakhri, H., additional, Yoshinaga, K., additional, Ochi, N., additional, Tomiyama, Y., additional, Katoh, C., additional, Inoue, M., additional, Nishida, M., additional, Suzuki, E., additional, Manabe, O., additional, Ito, Y., additional, Tamaki, N., additional, Tahilyani, A., additional, Jafary, F., additional, Ho Hee Hwa, H., additional, Ozdemir, S., additional, Kirilmaz, B., additional, Barutcu, A., additional, Tan, Y., additional, Celik, F., additional, Sakgoz, S., additional, Cabada Gamboa, M., additional, Puente Barragan, A., additional, Morales Vitorino, N., additional, Medina Servin, M., additional, Hindorf, C., additional, Akil, S., additional, Hedeer, F., additional, Jogi, J., additional, Engblom, H., additional, Martire, V., additional, Pis Diez, E., additional, Martire, M., additional, Portillo, D., additional, Hoff, C., additional, Balche, A., additional, Majgaard, J., additional, Tolbod, L., additional, Harms, H., additional, Soerensen, J., additional, Froekiaer, J., additional, Nudi, F., additional, Neri, G., additional, Procaccini, E., additional, Pinto, A., additional, Vetere, M., additional, Biondi-Zoccai, G., additional, Soares, J., additional, Do Val, R., additional, Oliveira, M., additional, Meneghetti, J., additional, Tekabe, Y., additional, Anthony, T., additional, Li, Q., additional, Schmidt, A., additional, Johnson, L., additional, Groenman, M., additional, Tarkia, M., additional, Kakela, M., additional, Halonen, P., additional, Kiviniemi, T., additional, Pietila, M., additional, Yla-Herttuala, S., additional, Roivainen, A., additional, Nekolla, S., additional, Swirzek, S., additional, Higuchi, T., additional, Reder, S., additional, Schachoff, S., additional, Bschorner, M., additional, Laitinen, I., additional, Robinson, S., additional, Yousefi, B., additional, Schwaiger, M., additional, Kero, T., additional, Lindsjo, L., additional, Antoni, G., additional, Westermark, P., additional, Carlson, K., additional, Wikstrom, G., additional, Sorensen, J., additional, Lubberink, M., additional, Rouzet, F., additional, Cognet, T., additional, Guedj, K., additional, Morvan, M., additional, El Shoukr, F., additional, Louedec, L., additional, Choqueux, C., additional, Nicoletti, A., additional, Le Guludec, D., additional, Jimenez-Heffernan, A., additional, Munoz-Beamud, F., additional, Sanchez De Mora, E., additional, Borrachero, C., additional, Salgado, C., additional, Ramos-Font, C., additional, Lopez-Martin, J., additional, Hidalgo, M., additional, Lopez-Aguilar, R., additional, Soriano, E., additional, Okizaki, A., additional, Nakayama, M., additional, Ishitoya, S., additional, Sato, J., additional, Takahashi, K., additional, Burchert, I., additional, Caobelli, F., additional, Wollenweber, T., additional, Nierada, M., additional, Fulsche, J., additional, Dieckmann, C., additional, Bengel, F., additional, Shuaib, S., additional, Mahlum, D., additional, Port, S., additional, Refoyo, E., additional, Cuesta, E., additional, Guzman, G., additional, Lopez, T., additional, Valbuena, S., additional, Del Prado, S., additional, Moreno, M., additional, Harbinson, M., additional, Donnelly, L., additional, Einstein, A. J., additional, Johnson, L. L., additional, Deluca, A. J., additional, Kontak, A. C., additional, Groves, D. W., additional, Stant, J., additional, Pozniakoff, T., additional, Cheng, B., additional, Rabbani, L. E., additional, Bokhari, S., additional, Schuetze, C., additional, Aguade-Bruix, S., additional, Pizzi, M., additional, Romero-Farina, G., additional, Terricabras, M., additional, Villasboas, D., additional, Castell-Conesa, J., additional, Candell-Riera, J., additional, Brunner, S., additional, Gross, L., additional, Todica, A., additional, Lehner, S., additional, Di Palo, A., additional, Niccoli Asabella, A., additional, Magarelli, C., additional, Notaristefano, A., additional, Ferrari, C., additional, Rubini, G., additional, Sellem, A., additional, Melki, S., additional, Elajmi, W., additional, Hammami, H., additional, Ziadi, M., additional, Montero, J., additional, Ameriso, J., additional, Villavicencio, R., additional, Benito Gonzalez, T. F., additional, Mayorga Bajo, A., additional, Gutierrez Caro, R., additional, Rodriguez Santamarta, M., additional, Alvarez Roy, L., additional, Martinez Paz, E., additional, Barinaga Martin, C., additional, Martin Fernandez, J., additional, Alonso Rodriguez, D., additional, Iglesias Garriz, I., additional, Rosillo, S., additional, Taleb, S., additional, Cherkaoui Salhi, G., additional, Regbaoui, Y., additional, Ait Idir, M., additional, Guensi, A., additional, Martin Lopez, C. E., additional, and Castano Ruiz, M., additional

Published
2015
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10. Abstracts

Author

Dunet, V., primary, Dabiri, A., additional, Allenbach, G., additional, Goyeneche Achigar, A., additional, Waeber, B., additional, Feihl, F., additional, Heinzer, R., additional, Prior, J. O., additional, Van Velzen, J. E., additional, Schuijf, J. D., additional, De Graaf, F. R., additional, De Graaf, M. A., additional, Schalij, M. J., additional, Kroft, L. J., additional, De Roos, A., additional, Jukema, J. W., additional, Van Der Wall, E. E., additional, Bax, J. J., additional, Lankinen, E., additional, Saraste, A., additional, Noponen, T., additional, Klen, R., additional, Teras, M., additional, Kokki, T., additional, Kajander, S., additional, Pietila, M., additional, Ukkonen, H., additional, Knuuti, J., additional, Pazhenkottil, A. P., additional, Nkoulou, R. N., additional, Ghadri, J. R., additional, Herzog, B. A., additional, Buechel, R. R., additional, Kuest, S. M., additional, Wolfrum, M., additional, Gaemperli, O., additional, Husmann, L., additional, Kaufmann, P. A., additional, Andreini, D., additional, Pontone, G., additional, Mushtaq, S., additional, Antonioli, L., additional, Bertella, E., additional, Formenti, A., additional, Cortinovis, S., additional, Ballerini, G., additional, Fiorentini, C., additional, Pepi, M., additional, Koh, A. S., additional, Flores, J. S., additional, Keng, F. Y. J., additional, Tan, R. S., additional, Chua, T. S. J., additional, Annoni, A. D., additional, Tamborini, G., additional, Fusari, M., additional, Bartorelli, A. L., additional, Ewe, S. H., additional, Ng, A. C. T., additional, Delgado, V., additional, Schuijf, J., additional, Van Der Kley, F., additional, Colli, A., additional, De Weger, A., additional, Marsan, N. A., additional, Yiu, K. H., additional, Ng, A. C., additional, Timmer, S. A. J., additional, Knaapen, P., additional, Germans, T., additional, Dijkmans, P. A., additional, Lubberink, M., additional, Ten Berg, J. M., additional, Ten Cate, F. J., additional, Russel, I. K., additional, Lammertsma, A. A., additional, Van Rossum, A. C., additional, Wong, Y. Y., additional, Ruiter, G., additional, Raijmakers, P., additional, Van Der Laarse, W. J., additional, Westerhof, N., additional, Vonk-Noordegraaf, A., additional, Youssef, G., additional, Leung, E., additional, Wisenberg, G., additional, Marriot, C., additional, Williams, K., additional, Etele, J., additional, Dekemp, R. A., additional, Dasilva, J., additional, Birnie, D., additional, Beanlands, R. S. B., additional, Thompson, R. C., additional, Allam, A. H., additional, Wann, L. S., additional, Nureldin, A. H., additional, Adelmaksoub, G., additional, Badr, I., additional, Sutherland, M. L., additional, Sutherland, J. D., additional, Miyamoto, M. I., additional, Thomas, G. S., additional, Harms, H. J., additional, De Haan, S., additional, Huisman, M. C., additional, Schuit, R. C., additional, Windhorst, A. D., additional, Allaart, C., additional, Einstein, A. J., additional, Khawaja, T., additional, Greer, C., additional, Chokshi, A., additional, Jones, M., additional, Schaefle, K., additional, Bhatia, K., additional, Shimbo, D., additional, Schulze, P. C., additional, Srivastava, A., additional, Chettiar, R., additional, Moody, J., additional, Weyman, C., additional, Natale, D., additional, Bruni, W., additional, Liu, Y., additional, Ficaro, E., additional, Sinusas, A. J., additional, Peix, A., additional, Batista, E., additional, Cabrera, L. O., additional, Padron, K., additional, Rodriguez, L., additional, Sainz, B., additional, Mendoza, V., additional, Carrillo, R., additional, Fernandez, Y., additional, Mena, E., additional, Naum, A., additional, Bach-Gansmo, T., additional, Kleven-Madsen, N., additional, Biermann, M., additional, Johnsen, B., additional, Aase Husby, J., additional, Rotevatn, S., additional, Nordrehaug, J. E., additional, Schaap, J., additional, Kauling, R. M., additional, Post, M. C., additional, Rensing, B. J. W. 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W., additional, Gama, V., additional, Ciarka, A., additional, Neefjes, L. A., additional, Mollet, N. R., additional, Sijbrands, E. J., additional, Wilczek, J., additional, Llibre Pallares, C., additional, Abdul-Jawad Altisent, O., additional, Cuellar Calabria, H., additional, Mahia Casado, P., additional, Gonzalez-Alujas, M. T., additional, Evangelista Masip, A., additional, Garcia-Dorado Garcia, D., additional, Tekabe, Y., additional, Shen, X., additional, Li, Q., additional, Luma, J., additional, Weisenberger, D., additional, Schmidt, A. M., additional, Haubner, R., additional, Johnson, L., additional, Sleiman, L., additional, Thorn, S., additional, Hasu, M., additional, Thabet, M., additional, Dasilva, J. N., additional, Whitman, S. C., additional, Genovesi, D., additional, Giorgetti, A., additional, Gimelli, A., additional, Cannizzaro, G., additional, Bertagna, F., additional, Fagioli, G., additional, Rossi, M., additional, Bonini, R., additional, Marzullo, P., additional, Paterson, C. A., additional, Smith, S. A., additional, Small, A. D., additional, Goodfield, N. E. R., additional, Martin, W., additional, Nekolla, S., additional, Sherif, H., additional, Reder, S., additional, Yu, M., additional, Kusch, A., additional, Li, D., additional, Zou, J., additional, Lloyd, M. S., additional, Cao, K., additional, Motherwell, D. W., additional, Rice, A., additional, Mccurrach, G. M., additional, Cobbe, S. M., additional, Petrie, M. C., additional, Al Younis, I., additional, Van Der Wall, E., additional, Mirza, T., additional, Raza, M., additional, Hashemizadeh, H., additional, Santos, L., additional, Krishna, B. A., additional, Perna, F., additional, Lago, M., additional, Leo, M., additional, Pelargonio, G., additional, Bencardino, G., additional, Narducci, M. L., additional, Casella, M., additional, Bellocci, F., additional, Kirac, S., additional, Yaylali, O., additional, Serteser, M., additional, Yaylali, T., additional, Okizaki, A., additional, Urano, Y., additional, Nakayama, M., additional, Ishitoya, S., additional, Sato, J., additional, Ishikawa, Y., additional, Sakaguchi, M., additional, Nakagami, N., additional, Aburano, T., additional, Solav, S. V., additional, Bhandari, R., additional, Burrell, S., additional, Dorbala, S., additional, Bruno, I., additional, Caldarella, C., additional, Collarino, A., additional, Mattoli, M. V., additional, Stefanelli, A., additional, Cannarile, A., additional, Maggi, F., additional, Soukhov, V., additional, Bondarev, S., additional, Yalfimov, A., additional, Khan, M., additional, Priyadharshan, P. 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E., additional, Vieira, E., additional, Balogh, I., additional, Kerecsen, G., additional, Marosi, E., additional, Szelid, Z. S., additional, Sattar, A., additional, Swadia, T., additional, Chattahi, J., additional, Qureshi, W., additional, Khalid, F., additional, Gonzalez, A., additional, Hechavarria, S., additional, Takamura, K., additional, Fujimoto, S., additional, Nakanishi, R., additional, Yamashina, S., additional, Namiki, A., additional, Yamazaki, J., additional, Koshino, K., additional, Hashikawa, Y., additional, Teramoto, N., additional, Hikake, M., additional, Ishikane, S., additional, Ikeda, T., additional, Iida, H., additional, Takahashi, Y., additional, Oriuchi, N., additional, Higashino, H., additional, Endo, K., additional, Mochizuki, T., additional, Murase, K., additional, Baali, A., additional, Moreno, R., additional, Chau, M., additional, Rousseau, H., additional, Nicoud, F., additional, Dolliner, P., additional, Brammen, L., additional, Steurer, G., additional, Traub-Weidinger, T., additional, Ubl, P., additional, Schaffarich, P., additional, Dobrozemsky, G., additional, Staudenherz, A., additional, Ozgen Kiratli, M., additional, Temelli, B., additional, Kanat, N. B., additional, Aksoy, T., additional, Slavich, G. A., additional, Piccoli, G., additional, Puppato, M., additional, Grillone, S., additional, Gasparini, D., additional, Dunet, V., additional, Perruchoud, S., additional, Poitry-Yamate, C., additional, Lepore, M., additional, Gruetter, R., additional, Pedrazzini, T., additional, Anselm, D., additional, Anselm, A., additional, Atkins, H., additional, Renaud, J., additional, Dekemp, R., additional, Burwash, I., additional, Guo, A., additional, Beanlands, R., additional, Glover, C., additional, Vilardi, I., additional, Zangheri, B., additional, Calabrese, L., additional, Romano, P., additional, Bruno, A., additional, Fernandez Cimadevilla, O. C., additional, Uusitalo, V. A., additional, Luotolahti, M., additional, Wendelin-Saarenhovi, M., additional, Sundell, J., additional, Raitakari, O., additional, Huidu, S., additional, Gadiraju, R., additional, Ghesani, M., additional, Uddin, Q., additional, Wosnitzer, B., additional, Takahashi, N., additional, Alhaj, E., additional, Legasto, A., additional, Abiri, B., additional, Elsaban, K., additional, El Khouly, T., additional, El Kammash, T., additional, Al Ghamdi, A., additional, Kyung Deok, B., additional, Bon Seung, K., additional, Sang Geun, Y., additional, Chang Min, D., additional, and Gwan Hong, M., additional

Published
2011
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12. An evaluation of coronary artery plaque burden in asymptomatic type 2 diabetics using dualsource CT coronary angiography.

Author

Patel, M., Mehta, V. S., Venuraju, S., Yerramasu, A., Jeevarethinam, A., Atwal, S., and Lahiri, A.

Subjects
ATHEROSCLEROTIC plaque, TYPE 2 diabetes, CORONARY artery stenosis, ARTERIAL diseases, ANGIOGRAPHY, MEDICAL screening, PATIENTS, DISEASE risk factors
Abstract

The article discuses the study on the association of coronary artery plaque and asymptomatic type 2 diabetes which can significantly cause stenosis in a coronary artery disease (CAD) patients. The method for the measuring the risk factors for CAD through computer tomography (CT) coronary angiogram (CTCA) was developed. The results were outlined and concludes the detection of plaques on more than half of the patients which suggest a revision of CAD screening to reduce morbidity and mortality.

Published
2012
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13. Post-infarction ventricular septal defect: percutaneous or surgical management in the UK national registry.

Author

Giblett JP, Matetic A, Jenkins D, Ng CY, Venuraju S, MacCarthy T, Vibhishanan J, O'Neill JP, Kirmani BH, Pullan DM, Stables RH, Andrews J, Buttinger N, Kim WC, Kanyal R, Butler MA, Butler R, George S, Khurana A, Crossland DS, Marczak J, Smith WHT, Thomson JDR, Bentham JR, Clapp BR, Buch M, Hayes N, Byrne J, MacCarthy P, Aggarwal SK, Shapiro LM, Turner MS, de Giovanni J, Northridge DB, Hildick-Smith D, Mamas MA, and Calvert PA

Subjects
Humans, Shock, Cardiogenic etiology, Aftercare, Treatment Outcome, Patient Discharge, Registries, United Kingdom epidemiology, Retrospective Studies, Heart Septal Defects, Ventricular surgery, Myocardial Infarction, Anterior Wall Myocardial Infarction
Abstract

Aims: Post-infarction ventricular septal defect (PIVSD) is a mechanical complication of acute myocardial infarction (AMI) with a poor prognosis. Surgical repair is the mainstay of treatment, although percutaneous closure is increasingly undertaken., Methods and Resuts: Patients treated with surgical or percutaneous repair of PIVSD (2010-2021) were identified at 16 UK centres. Case note review was undertaken. The primary outcome was long-term mortality. Patient groups were allocated based upon initial management (percutaneous or surgical). Three-hundred sixty-two patients received 416 procedures (131 percutaneous, 231 surgery). 16.1% of percutaneous patients subsequently had surgery. 7.8% of surgical patients subsequently had percutaneous treatment. Times from AMI to treatment were similar [percutaneous 9 (6-14) vs. surgical 9 (4-22) days, P = 0.18]. Surgical patients were more likely to have cardiogenic shock (62.8% vs. 51.9%, P = 0.044). Percutaneous patients were substantially older [72 (64-77) vs. 67 (61-73) years, P < 0.001] and more likely to be discussed in a heart team setting. There was no difference in long-term mortality between patients (61.1% vs. 53.7%, P = 0.17). In-hospital mortality was lower in the surgical group (55.0% vs. 44.2%, P = 0.048) with no difference in mortality after hospital discharge (P = 0.65). Cardiogenic shock [adjusted hazard ratio (aHR) 1.97 (95% confidence interval 1.37-2.84), P < 0.001), percutaneous approach [aHR 1.44 (1.01-2.05), P = 0.042], and number of vessels with coronary artery disease [aHR 1.22 (1.01-1.47), P = 0.043] were independently associated with long-term mortality., Conclusion: Surgical and percutaneous repair are viable options for management of PIVSD. There was no difference in post-discharge long-term mortality between patients, although in-hospital mortality was lower for surgery., Competing Interests: Conflict of interest: B.R.C. has received speaking fees from Abbott Vascular. P.M. has provided expert testimony and worked as a speaker for Edwards Lifesciences. J.B. has worked as a proctor for Abbott Vascular. M.S.T. has worked as a consultant and received educational grants from Occlutech. He has worked as a consultant and proctor for Abbott Vascular. D.B.N. has worked as a proctor for Abbott Vascular. D.H.-S. has received travel support and worked as a proctor for Abbott Vascular and Boston Scientific; he has received consulting fees and participated in a data and safety monitoring board for Abbott Vascular. M.A.M. has received non-restrictive educational grants from Abbott Vascular and Terumo, and worked as a consultant for Daiichi Sankyo and Terumo. P.A.C. has worked as a proctor for Abbott Vascular, Gore Medical and Occlutech., (© The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2022
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15. Predicting Severity of Coronary Artery Disease in Patients With Diabetes Using Endothelial Function Measured With Peripheral Arterial Tonometry: PROCEED Study.

Author

Venuraju S, Jeevarethinam A, Mehta VS, Ruano S, Dumo A, Nair D, Rosenthal M, Darko D, Cohen M, Rakhit R, and Lahiri A

Subjects
Aged, Computed Tomography Angiography, Coronary Angiography methods, Coronary Artery Disease etiology, Coronary Artery Disease physiopathology, Coronary Stenosis etiology, Coronary Stenosis physiopathology, Diabetes Mellitus, Type 2 diagnosis, Diabetes Mellitus, Type 2 physiopathology, Diabetic Angiopathies etiology, Diabetic Angiopathies physiopathology, Female, Humans, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests, Risk Assessment, Risk Factors, Severity of Illness Index, Coronary Artery Disease diagnosis, Coronary Stenosis diagnosis, Diabetes Mellitus, Type 2 complications, Diabetic Angiopathies diagnosis, Endothelium, Vascular physiopathology, Fingers blood supply, Manometry methods
Abstract

Endothelial dysfunction is common in patients with type 2 diabetes mellitus (T2DM) and is associated with atherosclerotic disease. This study aimed to determine prognostic factors for endothelial dysfunction and identify relationships between reactive hyperemia index (RHI) score, clinically relevant coronary artery disease (>50% stenosis), and major adverse cardiovascular events (MACEs) in patients with T2DM. Endothelial function was assessed using peripheral arterial tonometry and correlated with patient characteristics and cardiovascular outcomes during a median follow-up of 22.8 months. Among 235 patients with a median duration of T2DM of 13 years, mean (standard deviation) RHI score was 2.00 (0.76). Serum low- and high-density lipoprotein cholesterol levels positively ( P = .004) and negatively ( P = .02) predicted RHI score, respectively. Median coronary artery calcium (CAC) score was 109 Agatston units, but no correlation between CAC and RHI scores was observed. The RHI score did not predict the number or severity of coronary plaques identified using computed tomography coronary angiography. Additionally, there was no association between RHI score and the risk of an MACE during follow-up. Overall, endothelial function was not predictive of CAC score, extent, and severity of coronary plaque or MACEs and did not demonstrate utility in cardiovascular risk stratifying patients with T2DM.

Published
2019
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16. Usefulness of Carotid Plaques as Predictors of Obstructive Coronary Artery Disease and Cardiovascular Events in Asymptomatic Individuals With Diabetes Mellitus.

Author

Jeevarethinam A, Venuraju S, Dumo A, Ruano S, Rosenthal M, Nair D, Cohen M, Darko D, Lahiri A, and Rakhit R

Subjects
Aged, Carotid Artery Diseases diagnostic imaging, Carotid Intima-Media Thickness, Computed Tomography Angiography, Coronary Angiography, Coronary Stenosis diagnostic imaging, Female, Humans, Male, Middle Aged, Odds Ratio, Plaque, Atherosclerotic diagnostic imaging, Prospective Studies, United Kingdom epidemiology, Asymptomatic Diseases, Carotid Artery Diseases epidemiology, Coronary Stenosis epidemiology, Diabetes Mellitus, Type 2 epidemiology, Plaque, Atherosclerotic epidemiology
Abstract

Carotid intima-media thickness (CIMT) measurement and carotid plaque detection by B-mode ultrasound are frequently used as surrogates to predict coronary artery disease (CAD). However, their systematic use in routine clinical management of asymptomatic patients with diabetes mellitus (DM) has not been studied. The aim of the study was to identify carotid parameters that predict cardiovascular events in patients with asymptomatic type 2 DM by evaluating the relation between carotid disease and CAD. This multicenter, observational, prospective study included 259 asymptomatic patients with type 2 DM followed-up for 34 months after measurement of CIMT and carotid plaque with carotid ultrasound, and CAD assessment with computed tomography coronary angiography. Statistically significant differences between patients with and without carotid plaque were found for coronary plaque >50% stenosis (59 vs 36, p = 0.02). Greater maximal CIMT was associated with an increased risk of coronary plaque >50% (odds ratio 1.21 [1.02, 1.44], p = 0.03) and >70% stenosis (odds ratio 1.23 [1.01, 1.50], p = 0.04) after adjusting for traditional risk factors. At 34-month follow-up, the occurrence of total major adverse cardiovascular event was estimated to be 7.1% (mean age 68 years, 6% male and 1.1% female) in the whole study population. The subgroup of patients with carotid plaque showed increased incidence of major adverse cardiovascular event compared with patients with no carotid plaque (p = 0.005). In conclusion, carotid plaque was a strong predictor of future cardiovascular events and may be a prognostic marker in asymptomatic patients with type 2 DM. Carotid plaque and maximal intima-media thickness were independently associated with obstructive CAD., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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17. Relationship between carotid atherosclerosis and coronary artery calcification in asymptomatic diabetic patients: A prospective multicenter study.

Author

Jeevarethinam A, Venuraju S, Dumo A, Ruano S, Mehta VS, Rosenthal M, Nair D, Cohen M, Darko D, Lahiri A, and Rakhit R

Subjects
Adult, Aged, Asymptomatic Diseases, Carotid Arteries diagnostic imaging, Carotid Arteries pathology, Carotid Artery Diseases diagnostic imaging, Carotid Artery Diseases pathology, Carotid Intima-Media Thickness, Computed Tomography Angiography, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Coronary Vessels diagnostic imaging, Diabetes Mellitus, Type 2 diagnosis, Female, Humans, Logistic Models, London epidemiology, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Plaque, Atherosclerotic, Prevalence, Prospective Studies, Risk Factors, Severity of Illness Index, Ultrasonography, Doppler, Vascular Calcification diagnostic imaging, Carotid Artery Diseases epidemiology, Coronary Artery Disease epidemiology, Diabetes Mellitus, Type 2 epidemiology, Vascular Calcification epidemiology
Abstract

Background: The value of screening sub-clinical atherosclerosis in asymptomatic patients with type 2 diabetes mellitus (T2DM) remains controversial., Hypothesis: An integrated model incorporating carotid intima-media thickness (CIMT) and carotid plaque with traditional risk factors can be used to predict prevalence and severity of coronary artery calcification in asymptomatic T2DM patients., Methods: A cohort of 262 asymptomatic T2DM patients were prospectively studied with carotid ultrasound to evaluate CIMT and carotid plaque and also a computed tomography coronary artery calcium (CT-CAC) scan., Results: Carotid plaque was detected in 124 (47%) patients and mean CIMT was 0.75±0.14 mm. Two hundred (76%) patients had a CAC score >0, of whom 57 (22%) had severe coronary atherosclerosis (>400 Au). In this group, carotid plaque was present in 40 (70%) patients (p<0.001). Univariable analysis revealed significant associations between non-zero CAC score and age (p<0.001), hypertension (p=0.01), gender (p=0.003) and duration of diabetes (p=0.004). Carotid plaque and mean CIMT were also significantly associated with non-zero CAC score (odds ratios [95% CI], 3.12 [1.66 -5.85] and 2.98 [0.24 -7.17], respectively). After adjusting for traditional risk factors, carotid plaque continued to be predictive of non-zero CAC score (2.59 [1.17 -5.74]) and CIMT was borderline significant (p=0.05). When analysed with binary logistical regression, the prevalence of carotid plaque significantly predicted severe CAC burden (CAC >400 Au; 3.26 [2.05 -5.19]). Upper CIMT quartiles showed a similar association (2.55 [1.33 -4.87])., Conclusion: Carotid plaque is more predictive of underlying silent coronary atherosclerosis prevalence, severity and extent in asymptomatic T2DM patients., (© 2017 Wiley Periodicals, Inc.)

Published
2017
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19. Carotid intimal thickness and plaque predict prevalence and severity of coronary atherosclerosis: a pilot study.

Author

Jeevarethinam A, Venuraju S, Weymouth M, Atwal S, and Lahiri A

Subjects
Aged, Carotid Artery Diseases epidemiology, Coronary Artery Disease epidemiology, Female, Humans, Logistic Models, London epidemiology, Male, Middle Aged, Odds Ratio, Pilot Projects, Predictive Value of Tests, Prevalence, Risk Factors, Severity of Illness Index, Carotid Arteries diagnostic imaging, Carotid Artery Diseases diagnostic imaging, Carotid Intima-Media Thickness, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Coronary Vessels diagnostic imaging, Plaque, Atherosclerotic, Tomography, X-Ray Computed
Abstract

We determined whether increased carotid intima-media thickness (cIMT) and prevalence of carotid plaque (CP) are predictive of prevalence and severity of coronary atherosclerosis. Consecutive patients (n = 150) with no history of coronary artery disease (CAD), who underwent both carotid ultrasound and computed tomographic coronary angiography, were included in the analysis. The mean cIMT was higher in patients with CAD than in those without CAD (0.76 vs 0.66 mm, P < .003). In a logistic regression analysis, diabetes (P = .03) and CP (P = .02) were associated with significant coronary plaque. Backward selection analysis (after removing nonsignificant variables) showed higher mean cIMT measurement correlated well with prevalence of any coronary plaque (P = .03) and obstructive coronary plaque disease (P = .05), whereas presence of CP was a good predictor of both obstructive (>50% stenosis P = .003) and any coronary plaque (P = .003). In conclusion, CP and cIMT can be useful predictors of prevalence of CAD and its severity., (© The Author(s) 2014.)

Published
2015
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20. Diagnostic role of coronary calcium scoring in the rapid access chest pain clinic: prospective evaluation of NICE guidance.

Author

Yerramasu A, Lahiri A, Venuraju S, Dumo A, Lipkin D, Underwood SR, Rakhit RD, and Patel DJ

Subjects
Algorithms, Contrast Media, Electrocardiography, Female, Humans, Iopamidol analogs & derivatives, London, Male, Middle Aged, Pain Clinics, Predictive Value of Tests, Prospective Studies, Radiographic Image Interpretation, Computer-Assisted, Sensitivity and Specificity, Calcinosis diagnostic imaging, Chest Pain diagnostic imaging, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Practice Guidelines as Topic, Tomography, X-Ray Computed methods
Abstract

Background: Coronary artery calcium (CAC) imaging by unenhanced computed X-ray tomography (CT) is recommended as an initial diagnostic test for patients with stable chest pain symptoms but a low likelihood (10-29%) of underlying obstructive coronary artery disease (CAD) after clinical assessment. The recommendation has not previously been tested prospectively in a rapid access chest pain clinic (RACPC)., Methods: We recruited 300 consecutive patients presenting with stable chest pain to the RACPC of three hospitals. All patients underwent CAC imaging, followed by invasive coronary angiography (ICA) in patients with CAC ≥ 1000 Agatston units (Au) and CT coronary angiography (CTCA) in those with CAC <1000. Patients with 50-70% stenosis on CTCA underwent myocardial perfusion scintigraphy (MPS) while those with ≥ 70% stenosis underwent ICA. Obstructive CAD was defined as ≥ 70% stenosis on ICA or the presence of inducible ischaemia on MPS. Patients were followed up clinically for a mean of 17 (SD 6) months., Results: The mean patient age was 60.6 (SD 9.6) years and 48% were males. Obstructive CAD was found in 56 (19%) patients, of whom 42 (14%) underwent revascularization. CAC was zero in 131 (44%) patients, of whom two (1.5%) had obstructive CAD and one (0.8%) underwent revascularization. The sensitivity, specificity, negative predictive value, and positive predictive value of CAC ≥ 1 for detection of obstructive CAD were 96, 53, 32, and 98%, respectively. None of the 57 patients with low pre-test probability of CAD and zero CAC had obstructive CAD or suffered a cardiovascular event during the follow-up., Conclusion: Patients with stable chest pain symptoms but a low likelihood of CAD can safely be diagnosed as not having obstructive CAD in the absence of detectable coronary calcification by unenhanced CT. Patients with CAC >400 Au have a high prevalence of obstructive CAD and further investigation with ICA or functional imaging may be warranted rather than CTCA. These findings support NICE guidance for the investigation of stable chest pain. ClinicalTrials gov identifier: NCT01464203., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.)

Published
2014
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21. Myocardial Scar Detection by Standard CT Coronary Angiography.

Author

Jeevarethinam A, Venuraju S, Mehta VS, Atwal S, Raval U, Rakhit R, Davar J, and Lahiri A

Abstract

We have described a myocardial infarct scar identified by a standard dual source CT coronary angiography (CTCA). We were able to detect the scar during the routine coronary assessment without contrast late enhancement and without additional radiation exposure. It is therefore feasible to assess chronic scar using a standard CTCA technique.

Published
2014
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22. Varying accuracy of myocardial perfusion SPECT and perfusion cardiac MRI for the detection of critical LMS coronary disease.

Author

Jeevarethinam A, Venuraju S, Raval U, Lipkin D, and Lahiri A

Subjects
Coronary Angiography methods, Coronary Artery Disease complications, Electrocardiography methods, Humans, Male, Middle Aged, Perfusion, Prognosis, Reproducibility of Results, Technetium, Tomography, Emission-Computed, Single-Photon methods, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease pathology, Magnetic Resonance Imaging methods, Myocardial Perfusion Imaging methods
Published
2013
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23. Radiation dose of CT coronary angiography in clinical practice: objective evaluation of strategies for dose optimization.

Author

Yerramasu A, Venuraju S, Atwal S, Goodman D, Lipkin D, and Lahiri A

Subjects
Algorithms, Cardiac-Gated Imaging Techniques, Contrast Media, Cross-Sectional Studies, Female, Humans, Linear Models, Male, Middle Aged, Prospective Studies, Signal-To-Noise Ratio, Statistics, Nonparametric, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Radiation Dosage, Tomography, X-Ray Computed methods
Abstract

Background: CT coronary angiography (CTCA) is an evolving modality for the diagnosis of coronary artery disease. Radiation burden associated with CTCA has been a major concern in the wider application of this technique. It is important to reduce the radiation dose without compromising the image quality., Objectives: To estimate the radiation dose of CTCA in clinical practice and evaluate the effect of dose-saving algorithms on radiation dose and image quality., Methods: Effective radiation dose was measured from the dose-length product in 616 consecutive patients (mean age 58 ± 12 years; 70% males) who underwent clinically indicated CTCA at our institution over 1 year. Image quality was assessed subjectively using a 4-point scale and objectively by measuring the signal- and contrast-to-noise ratios in the coronary arteries. Multivariate linear regression analysis was used to identify factors independently associated with radiation dose., Results: Mean effective radiation dose of CTCA was 6.6 ± 3.3 mSv. Radiation dose was significantly reduced by dose saving algorithms such as 100 kV imaging (-47%; 95% CI, -44% to -50%), prospective gating (-35%; 95% CI, -29% to -40%) and ECG controlled tube current modulation (-23%; 95% CI, -9% to -34%). None of the dose saving algorithms were associated with a significant reduction in mean image quality or the frequency of diagnostic scans (P = non-significant for all comparisons)., Conclusion: Careful application of radiation-dose saving algorithms in appropriately selected patients can reduce the radiation burden of CTCA significantly, without compromising the image quality., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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24. Increased volume of epicardial fat is an independent risk factor for accelerated progression of sub-clinical coronary atherosclerosis.

Author

Yerramasu A, Dey D, Venuraju S, Anand DV, Atwal S, Corder R, Berman DS, and Lahiri A

Subjects
Analysis of Variance, Asymptomatic Diseases, Coronary Artery Disease epidemiology, Diabetes Mellitus diagnostic imaging, Diabetes Mellitus epidemiology, Disease Progression, Female, Humans, London epidemiology, Male, Metabolic Syndrome diagnostic imaging, Metabolic Syndrome epidemiology, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prevalence, Prospective Studies, Regression Analysis, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors, Vascular Calcification diagnostic imaging, Vascular Calcification epidemiology, Adipose Tissue diagnostic imaging, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Pericardium diagnostic imaging, Tomography, X-Ray Computed
Abstract

Background: Epicardial adipose tissue (EAT), a metabolically active visceral fat depot surrounding the heart, has been implicated in the pathogenesis of coronary artery disease (CAD) through possible paracrine interaction with the coronary arteries. We examined the association of EAT with metabolic syndrome and the prevalence and progression of coronary artery calcium (CAC) burden., Methods: CAC scan was performed in 333 asymptomatic diabetic patients without prior history of CAD (median age 54 years, 62% males), followed by a repeat scan after 2.7±0.3 years. CAC progression was defined as >2.5mm(3) increase in square root transformed volumetric CAC scores. EAT and intra-thoracic fat volumes were quantified using a dedicated software (QFAT), and were examined in relation to the metabolic syndrome, baseline CAC scores and CAC progression., Results: Both epicardial and intra-thoracic fat were associated with metabolic syndrome after adjustment for conventional cardiovascular risk factors, but the association was attenuated after additional adjustment for body mass index. EAT, but not intra-thoracic fat, showed significant association with baseline CAC scores (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.04-1.22, p=0.04) and CAC progression (OR 1.12, 95% CI 1.05-1.19, p<0.001) after adjustment for conventional measures of obesity and risk factors., Conclusion: EAT volume measured on non-contrast CT is an independent marker for the presence and severity of coronary calcium burden and also identifies individuals at increased risk of CAC progression. EAT quantification may thus add to the prognostic value of CAC imaging., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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25. Evolving role of cardiac CT in the diagnosis of coronary artery disease.

Author

Yerramasu A, Venuraju S, and Lahiri A

Subjects
Coronary Angiography adverse effects, Humans, Risk Factors, Tomography, X-Ray Computed adverse effects, Coronary Angiography methods, Coronary Artery Disease diagnostic imaging, Tomography, X-Ray Computed methods
Abstract

Non-invasive assessment of coronary artery patency has been attempted with different imaging modalities over the last few decades. The continuous motion of the heart, the respiratory movement, together with the small and tortuous nature of the coronary arteries, made this a technically challenging task. Over the last decade, significant advances in computed tomography (CT) technology helped CT coronary angiography (CTCA) to evolve as a non-invasive alternative to conventional catheter based coronary angiography. Clinical experience with CTCA has since grown rapidly and led to its acceptance as a useful diagnostic technique for coronary artery disease in certain patient populations. Recently, there has been exponential growth in the availability and use of CTCA in several centres across the world. In order to appreciate the potential impact of CTCA on current clinical practice, it is important to understand its advantages and limitations and its clinical performance in comparison with established techniques.

Published
2011
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26. Socioeconomic status and subclinical coronary disease in the Whitehall II epidemiological study.

Author

Steptoe A, Hamer M, O'Donnell K, Venuraju S, Marmot MG, and Lahiri A

Subjects
Aged, Calcinosis, Cohort Studies, Coronary Disease pathology, Coronary Disease psychology, Female, Humans, Life Style, Male, Middle Aged, United Kingdom epidemiology, Coronary Disease epidemiology, Social Class
Abstract

Background: There are pronounced socioeconomic disparities in coronary heart disease, but the extent to which these primarily reflect gradients in underlying coronary artery disease severity or in the clinical manifestation of advanced disease is uncertain. We measured the relationship between socioeconomic status (SES) as indexed by grade of employment and coronary artery calcification (CAC) in the Whitehall II epidemiological cohort, and tested the contribution of lifestyle, biological and psychosocial factors in accounting for this association., Methods and Findings: CAC was assessed in 528 asymptomatic men and women aged 53-76 years, stratified into higher, intermediate and lower by grade of employment groups. Lifestyle (smoking, body mass index, alcohol consumption, physical activity), biological (blood pressure, lipids, fasting glucose, inflammatory markers) and psychosocial factors (work stress, financial strain, social support, depression, hostility, optimism) were also measured. Detectable CAC was present in 293 participants (55.5%). The presence of calcification was related to lifestyle and biological risk factors, but not to grade of employment. But among individuals with detectable calcification, the severity of CAC was inversely associated with grade of employment (p = 0.010), and this relationship remained after controlling for demographic, lifestyle, biological and psychosocial factors. Compared with the higher grade group, there was a mean increase in log Agatston scores of 0.783 (95% C.I. 0.265-1.302, p = 0.003) in the intermediate and 0.941 (C.I. 0.226-1.657, p = 0.010) in the lower grade of employment groups, after adjustment for demographic, lifestyle, biological and psychosocial factors., Conclusions: Low grade of employment did not predict the presence of calcification in this cohort, but was related to the severity of CAC. These findings suggest that lower SES may be particularly relevant at advanced stages of subclinical coronary artery disease, when calcification has developed.

Published
2010
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