1. The Role of Vascular Lesions in Diabetes Across a Spectrum of Clinical Kidney Disease
- Author
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Francisco Moreso, Meritxell Ibernon, Miguel Bigotte Vieira, Enrique Morales, Fedaa Ghanem, Radovan Hojs, Esteban Porrini, Alberto Ortiz, Maruja Navarro Díaz, Clara García Garro, Clara María Cases Corona, Bo Feldt-Rasmussen, Gema Fernández, Mads Hornum, Sebastjan Bevc, Patricia Fox Concepción, Rosa Rodríguez-Rodriguez, Luis Mendonça, Arianna Bettiga, Manuel Praga, Natalia Negrín Mena, Khaled Khazim, Beatriz Fernandez-Fernandez, Federico Di Marco, Marina López Martínez, Francesco Trevisani, Maria Quero, Ivo Laranjinha, Josep M. Cruzado, Institut Català de la Salut, [Rodríguez-Rodríguez R] Hospital Universitario de Canarias, Pathology Department, Tenerife, Spain. University of La Laguna, Faculty of Medicine, Tenerife, Spain. [Hojs R, Bevc S] Department of Nephrology, Clinic for Internal Medicine, University Clinical Centre Maribor and Faculty of Medicine, University of Maribor, Slovenia. [Trevisani F] IRCCS Ospedale San Raffaele, URI–Urological Research Institute, Milano, Italy. [Morales E] Hospital 12 de Octubre, Madrid, Spain. [Fernández G] Hospital Universitario Fundación Alcorcón, Madrid, Spain. REDINREN ISCIII, Madrid, Spain. [Moreso F] REDINREN ISCIII, Madrid, Spain. Vall d'Hebron Hospital Universitari, Barcelona, Spain. [García Garro C] Vall d'Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, and Proteïnúria
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Urology ,Renal function ,Nefropaties diabètiques - Etiologia ,normoalbuminuria ,urologic and male genital diseases ,albuminuria ,Diabetic nephropathy ,histology ,Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Nephropathies [DISEASES] ,Other subheadings::/etiology [Other subheadings] ,Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores] ,Clinical Research ,Diabetes mellitus ,Otros calificadores::/etiología [Otros calificadores] ,Diabetic nephropathies ,medicine ,Vasos sanguinis - Malalties - Complicacions ,enfermedades cardiovasculares [ENFERMEDADES] ,Proteinuria ,diabetes ,Cardiovascular Diseases [DISEASES] ,urogenital system ,business.industry ,diabetic nephropathy ,Nefropaties diabètiques ,medicine.disease ,Nephrectomy ,female genital diseases and pregnancy complications ,enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::nefropatías diabéticas [ENFERMEDADES] ,Nephrology ,Albuminuria ,Microalbuminuria ,medicine.symptom ,business ,chronic kidney disease ,Kidney disease ,Other subheadings::Other subheadings::/complications [Other subheadings] - Abstract
Introduction The clinical-histologic correlation in diabetic nephropathy is not completely known. Methods We analyzed nephrectomy specimens from 90 patients with diabetes and diverse degrees of proteinuria and glomerular filtration rate (GFR). Results Thirty-six (40%) subjects had normoalbuminuria, 33 (37%) microalbuminuria, and 21 (23%) non-nephrotic proteinuria. Mean estimated GFR (eGFR) was 65±23 (40% 10% to 20% of the sample. Moderate hyalinosis and arteriolar sclerosis were observed in 80% to 100% of cases with normoalbuminuria, microalbuminuria, proteinuria, as well as in class I, II, or III. Conclusions Weak correspondence between analytical parameters and kidney histology was found. Thus, disease may progress undetected from the early clinical stages of the disease. Finally, vascular damage was a very common finding, which highlights the role of ischemic intrarenal disease in diabetes., Graphical abstract
- Published
- 2021