Back to Search
Start Over
The Role of Vascular Lesions in Diabetes Across a Spectrum of Clinical Kidney Disease
- Source :
- Scientia, Rodríguez-Rodríguez, R, Hojs, R, Trevisani, F, Morales, E, Fernández, G, Bevc, S, Cases Corona, C M, Cruzado, J M, Quero, M, Navarro Díaz, M, Bettiga, A, Di Marco, F, López Martínez, M, Moreso, F, García Garro, C, Khazim, K, Ghanem, F, Praga, M, Ibernón, M, Laranjinha, I, Mendonça, L, Bigotte Vieira, M, Hornum, M, Feldt-Rasmussen, B, Fernández-Fernández, B, Concepción, P F, Negrín Mena, N, Ortiz, A, Porrini, E & DIABESITY working group of the ERA 2021, ' The Role of Vascular Lesions in Diabetes Across a Spectrum of Clinical Kidney Disease ', Kidney International Reports, vol. 6, no. 9, pp. 2392-2403 . https://doi.org/10.1016/j.ekir.2021.06.001, Dipòsit Digital de la UB, Universidad de Barcelona, Kidney International Reports
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Introduction The clinical-histologic correlation in diabetic nephropathy is not completely known. Methods We analyzed nephrectomy specimens from 90 patients with diabetes and diverse degrees of proteinuria and glomerular filtration rate (GFR). Results Thirty-six (40%) subjects had normoalbuminuria, 33 (37%) microalbuminuria, and 21 (23%) non-nephrotic proteinuria. Mean estimated GFR (eGFR) was 65±23 (40% 10% to 20% of the sample. Moderate hyalinosis and arteriolar sclerosis were observed in 80% to 100% of cases with normoalbuminuria, microalbuminuria, proteinuria, as well as in class I, II, or III. Conclusions Weak correspondence between analytical parameters and kidney histology was found. Thus, disease may progress undetected from the early clinical stages of the disease. Finally, vascular damage was a very common finding, which highlights the role of ischemic intrarenal disease in diabetes.<br />Graphical abstract
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Urology
Renal function
Nefropaties diabètiques - Etiologia
normoalbuminuria
urologic and male genital diseases
albuminuria
Diabetic nephropathy
histology
Endocrine System Diseases::Diabetes Mellitus::Diabetes Complications::Diabetic Nephropathies [DISEASES]
Other subheadings::/etiology [Other subheadings]
Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores]
Clinical Research
Diabetes mellitus
Otros calificadores::/etiología [Otros calificadores]
Diabetic nephropathies
medicine
Vasos sanguinis - Malalties - Complicacions
enfermedades cardiovasculares [ENFERMEDADES]
Proteinuria
diabetes
Cardiovascular Diseases [DISEASES]
urogenital system
business.industry
diabetic nephropathy
Nefropaties diabètiques
medicine.disease
Nephrectomy
female genital diseases and pregnancy complications
enfermedades del sistema endocrino::diabetes mellitus::complicaciones de la diabetes::nefropatías diabéticas [ENFERMEDADES]
Nephrology
Albuminuria
Microalbuminuria
medicine.symptom
business
chronic kidney disease
Kidney disease
Other subheadings::Other subheadings::/complications [Other subheadings]
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scientia, Rodríguez-Rodríguez, R, Hojs, R, Trevisani, F, Morales, E, Fernández, G, Bevc, S, Cases Corona, C M, Cruzado, J M, Quero, M, Navarro Díaz, M, Bettiga, A, Di Marco, F, López Martínez, M, Moreso, F, García Garro, C, Khazim, K, Ghanem, F, Praga, M, Ibernón, M, Laranjinha, I, Mendonça, L, Bigotte Vieira, M, Hornum, M, Feldt-Rasmussen, B, Fernández-Fernández, B, Concepción, P F, Negrín Mena, N, Ortiz, A, Porrini, E & DIABESITY working group of the ERA 2021, ' The Role of Vascular Lesions in Diabetes Across a Spectrum of Clinical Kidney Disease ', Kidney International Reports, vol. 6, no. 9, pp. 2392-2403 . https://doi.org/10.1016/j.ekir.2021.06.001, Dipòsit Digital de la UB, Universidad de Barcelona, Kidney International Reports
- Accession number :
- edsair.doi.dedup.....c31e0bf815704acc4279b122067fd889