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1. Blockchain for CCTV Surveillance

Author

Dharani, D., Anitha Kumari, K., Vasanthan, R., Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Peter, J. Dinesh, editor, Fernandes, Steven Lawrence, editor, and Alavi, Amir H., editor

Published
2022
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6. The Role of School Administrators in Supporting Differentiation in Business English Classrooms in India

Author

Vasanthan, R. and Keerthi, D.

Subjects
Best practices, Impact, Differentiation, Higher education administrators, India, Programs, Strategies, Challenges, Recommendations, Policies, Business English classrooms, Resources
Abstract

This study aimed to examine the policies, programs, and resources provided by higher education administrators in India to support differentiation in business English classrooms. The study also evaluated the impact of administrators' support on differentiation, explored strategies and best practices for supporting differentiation, and assessed the challenges faced by administrators. The results showed that higher education administrators in India have implemented various policies and programs to support differentiation in business English classrooms, including the use of technology and digital tools, innovative practices, and online courses. However, the study also revealed that there is still a gap in terms of supporting classroom management, considering learner preferences, and promoting variety in classrooms to break monotony. To overcome these challenges, higher education administrators were recommended to prioritize collaboration with teachers, provide professional development opportunities, and allocate sufficient resources for differentiation in business English classrooms.

Published
2023

7. Effect Of Hr Analytics, Human Capital Management On Organisational Performance

Author

Kiran, P.V.S., Sujatha, R., Estherita, S. Anisha, Vasanthan, R., Kiran, P.V.S., Sujatha, R., Estherita, S. Anisha, and Vasanthan, R.

Abstract

Human Resource Analytics also termed as Workforce Analytics and Talent Analytics is the integration of Analytics (HRA) with Human Capital Management (HCM) that helps in improving the output of Human Capital. HR analytics develops the data relating to human resources to improve the workforce’s performance of the organization. The purpose of this study is to review literature on the effect of HR analytics and human capital management (HCM) on organizational performance and empirically test the formulated hypothesis through regression analysis. Questionnaire survey was conducted among the different levels of management of people belong to service industry. Stratified random sampling technique was adopted to select 300 respondents. The study demonstrates that HR analytics supports the various practices of Human capital management. The research also proves that HR analytics and HCM positively impact the performance of the organizations in the service industry.

Published
2023

8. History of English Literature: For a Grasp

Author

Dr. Vasanthan R

Abstract

It is with great pleasure that I present this book, “History of English Literature: For a Grasp.” This book is an effort to provide a clear and concise overview of the history of English literature, from the Old English period to the present day. The objective of this book is to make the subject of English literature easy to understand for anyone with an interest in the subject. The book is organized chronologically, beginning with the Old English period and progressing through the Middle English period, Elizabethan period, Jacobean period, Caroline period, Commonwealth and Restoration period, Age of Dryden, Neoclassical period, Romantic period, Victorian age, Edwardian period, Georgian period, Modern period, and finally the Postmodern period.

Published
2023
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9. A Study on Establishing Conversations and Failing to Build Conversations in Business Senario

Author

Vasanthan, R. and Keerthi, D.

Subjects
Discussion, Questionnaire
Abstract

The outcomes of a conversation are related to concerns that the conversationalists are aware of and unaware of. Indulging in a discussion using familiar words and terms allows for both access and departure, as well as inadvertent agreement, even before getting to the heart of the topic. There are aspects that influence how well a discussion is orchestrated, and a planned strategy for a circumstance using standard phrases does not always ensure success. The goal of this study is to evaluate the challenges of engaging in a discussion using the traditional technique, as well as the potential of expanding the bounds of situational language education and language for a specific purpose in the environment. The study's premise is that sticking to known words, phrases, and sentences does not always produce the ideal conversational platform, and that learning language based on a context may meet the fundamental criteria but does not always ensure success. Because they may have greater expertise in engaging in dialogues, an internet survey with a questionnaire was created to study the thoughts and opinions of persons in the field of marketing and company promotion. The data was evaluated and clarified, pointing to potential study areas.

Published
2022

10. Literature for gender sensitivity: An overview

Author

Vasanthan, R., Joy, Ancymol, Vasanthan, R., and Joy, Ancymol

Abstract

Literature has always been a key component in the development of children's linguistic skills as well as their moral awareness. This study will look at how literature can be used to teach gender awareness as well as other aspects of learning to literature students. A survey was conducted using a series of questions to learn about literature students' perceptions about the use of literature for emotional refinement. Based on the replies, a thorough evaluation has been conducted, and suggestions for classroom discussion, as well as the possibilities for further research, have been provided.

Published
2022

11. A LETTER FROM SPECIAL EDITION EDITOR IN CHIEF - DR. VASANTHAN. R

Author

Vasanthan. R

Subjects
Strategy and Management, Mechanical Engineering, Metals and Alloys, Industrial and Manufacturing Engineering
Abstract

The Department of English (UAP) has successfully organised a Two-Day International Conference on "Learning Language and Literature for Life (4L)" on the 9th and 10th of September 2022. About 44 colleges participated in the conference, and a total of 270 presenters attended it. Parallel sessions were conducted at four venues with the distinguished keynote speakers, Dr. P.K Patra from Bodoland University, Assam; Dr. Seng Tong Chong, University Tenaga Nasional, Malaysia; Dr. Mohammed Shamsul Hoque, Daffodil International University, Bangladesh; Dr. Pasa Tevfik Cephe, Gazi University, Turkey and Dr. Michael Greaney, Lancaster University, United Kingdom. The presentation sessions were chaired by prominent resource persons from various colleges in Tamil Nadu. The conference's main objective was to encourage scholars to have an insight into the different areas of English language and literature research. The discussions during the paper presentations proved to be a great opportunity for exchanging knowledge among great minds. Among the 270 papers received, 17 papers related to scope were selected to be published in the UGC Care-Listed Journal "ShodhKosh: Journal of Visual and Performing Arts" as a special issue titled "Depiction of Women in Artistic Works". I express my sincere thanks to the publisher of Granthaalayah Publications for his noble partnership with the institution to motivate researchers with due recognition. The Department of English (UAP) looks forward to take this partnership to the next level with substantial research contributions to promote art forms in general and literary arts in particular. Sincerely,Dr. Vasanthan.R

Published
2023
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12. Effect of Kinesiotaping for Hand Function in Children with Cerebral Palsy: A Randomized Controlled Trial.

Author

James, Jeena, Javed, Jasrah, Mohan, Divya, and Vasanthan, R.

Subjects
TAPING & strapping, FUNCTIONAL status, CHILDREN with disabilities, RANDOMIZED controlled trials, TREATMENT effectiveness, T-test (Statistics), HAND, QUALITY of life, CEREBRAL palsy, STATISTICAL sampling, INTELLECTUAL disabilities, CHILDREN
Abstract

Background: Cerebral palsy is the most common chronic disability. Lesions or defects in the immature brain cause sensori motor impairment, which compromise the development of upper limb function in cerebral palsy. Restricted movement of the upper limbs may cause limitation in the functions and performance of ADL which affect their quality of life. Recent studies have proven that kinesiotape plays an important role in the management of hand functional activity. Design: Randomized controlled trail was conducted on 28 cerebral palsy children with impaired hand function were included in the study based on the inclusion and exclusion criteria. Participants were randomly divided into 2 groups, group a. kinesiotaping with functional hand activities and group b. sham taping (Kinesiotape without tension) along with functional hand activities. Control group received sham tape (kinesiotape without tension). Outcomes were measured using quality of upper extremity skill test (QUEST) and Upper limb physician rating scale (ULPRS). Conclusion: The study proved that the short term effect of kinesiotaping application along with functional hand activities has no significant effect on improving hand function in children with cerebral palsy. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Health Care Needs Across Different Age Groups in Children with Cerebral Palsy: A Survey.

Author

Sony, Riya, Javed, Jasrah, Mohan, Divya, and Vasanthan, R.

Subjects
KRUSKAL-Wallis Test, STATISTICS, AGE distribution, FUNCTIONAL status, CROSS-sectional method, CHILDREN with disabilities, PEDIATRICS, COMPARATIVE studies, QUESTIONNAIRES, DESCRIPTIVE statistics, CEREBRAL palsy, DATA analysis, MEDICAL needs assessment, GOAL (Psychology), PARENTS
Abstract

Background: Cerebral palsy (CP) is the most common chronic childhood disability of today. Health care needs are present in these children who require health services to manage their functional disability. It can change according to the age group and severity of the condition. In the current healthcare system, little is known about priorities and needs for the children with cerebral palsy especially in reference to Indian contextual situations and how these needs may differ based on the child's age and motor function. Methods: A cross sectional survey design is used in the study. 83 parents of children with cerebral palsy and their treating physiotherapists were selected in the study based on the inclusion and exclusion criteria. Participants were divided into 3 groups based on the age of the children. Self designed questionnaire was given to the parents and the physiotherapists to select the health care needs for the children. One time data collection was done over the period of 3 months. Conclusion: The study also shows that mostly parent's needs are considered by physiotherapists for their goal settings. Most of the time parents' needs and the physiotherapist's goals are found to be similar. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Deceased donor renal transplant outcome in a south Indian tertiary care hospital with zonal allocation model - An observational study

Author

Sadayandi, Kandasamy, primary, Madhavan, Devdas, additional, Murugesan, Prabu, additional, Mathavan, Balamurugan, additional, Narayanasamy, Kuppurajan, additional, Baranikumar, PollachiBalasundaraj, additional, Murugesan, Anandan, additional, Balasundaram, SengodaG, additional, Sengottayan, VengeteshKilvani, additional, Vasanthan, R, additional, and Jeevithan, S, additional

Published
2022
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15. Carga global, regional y nacional de neurológicas. Desórdenes, 1990-2016: un análisis sistemático para el Global Estudio de la carga de enfermedad 2016

Author

Feigin V, Nichols E, Alam T, Bannick M, Beghi E, Blake N, Culpepper W, Dorsey E, Elbaz A, Ellenbogen R, Fisher J, Fitzmaurice C, Giussani G, Glennie L, James S, Johnson C, Kassebaum N, Logroscino G, Marin B, Mountjoy-Venning W, Nguyen M, Ofori-Asenso R, Patel A, Piccininni M, Roth G, Steiner T, Stovner L, Szoeke C, Theadom A, Vollset S, Wallin M, Wright C, Zunt J, Abbasi N, Abd-Allah F, Abdelalim A, Abdollahpour I, Aboyans V, Abraha H, Acharya D, Adamu A, Adebayo O, Adeoye A, Adsuar J, Afarideh M, Agrawal S, Ahmadi A, Ahmed M, Aichour A, Aichour I, Aichour M, Akinyemi R, Akseer N, Al-Eyadhy A, Salman R, Alahdab F, Alene K, Aljunid S, Altirkawi K, Alvis-Guzman N, Anber N, Antonio C, Arabloo J, Aremu O, Arnlov J, Asayesh H, Asghar R, Atalay H, Awasthi A, Quintanilla B, Ayuk T, Badawi A, Banach M, Banoub J, Barboza M, Barker-Collo S, Barnighausen T, Baune B, Bedi N, Behzadifar M, Bejot Y, Bekele B, Belachew A, Bennett D, Bensenor I, Berhane A, Beuran M, Bhattacharyya K, Bhutta Z, Biadgo B, Bijani A, Bililign N, Bin Sayeed M, Blazes C, Brayne C, Butt Z, Campos-Nonato I, Cantu-Brito C, Car M, Cardenas R, Carrero J, Carvalho F, Castaneda-Orjuela C, Castro F, Catala-Lopez F, Cerin E, Chaiah Y, Chang J, Chatziralli I, Chiang P, Christensen H, Christopher D, Cooper C, Cortesi P, Costa V, Criqui M, Crowe C, Damasceno A, Daryani A, De la Cruz-Gongora V, De la Hoz F, De Leo D, Degefa M, Demoz G, Deribe K, Dharmaratne S, Diaz D, Dinberu M, Djalalinia S, Doku D, Dubey M, Dubljanin E, Duken E, Edvardsson D, El-Khatib Z, Endres M, Endries A, Eskandarieh S, Esteghamati A, Esteghamati S, Farhadi F, Faro A, Farzadfar F, Farzaei M, Fatima B, Fereshtehnejad S, Fernandes E, Feyissa G, Filip I, Fischer F, Fukumoto T, Ganji M, Gankpe F, Garcia-Gordillo M, Gebre A, Gebremichael T, Gelaw B, Geleijnse J, Geremew D, Gezae K, Ghasemi-Kasman M, Gidey M, Gill P, Gill T, Gnedovskaya E, Goulart A, Grada A, Grosso G, Guo Y, Gupta R, Haagsma J, Hagos T, Haj-Mirzaian A, Hamadeh R, Hamidi S, Hankey G, Hao Y, Haro J, Hassankhani H, Hassen H, Havmoeller R, Hay S, Hegazy M, Heidari B, Henok A, Heydarpour F, Hoang C, Hole M, Rad E, Hosseini S, Hu G, Igumbor E, Ilesanmi O, Irvani S, Islam S, Jakovljevic M, Javanbakht M, Jha R, Jobanputra Y, Jonas J, Jozwiak J, Jurisson M, Kahsay A, Kalani R, Kalkonde Y, Kamil T, Kanchan T, Karami M, Karch A, Karimi N, Kasaeian A, Kassa T, Kassa Z, Kaul A, Kefale A, Keiyoro P, Khader Y, Khafaie M, Khalil I, Khan E, Khang Y, Khazaie H, Kiadaliri A, Kiirithio D, Kim A, Kim D, Kim Y, Kisa A, Kokubo Y, Koyanagi A, Krishnamurthi R, Defo B, Bicer B, Kumar M, Lacey B, Lafranconi A, Lansingh V, Latifi A, Leshargie C, Li S, Liao Y, Linn S, Lo W, Lopez J, Lorkowski S, Lotufo P, Lucas R, Lunevicius R, Mackay M, Mahotra N, Majdan M, Majdzadeh R, Majeed A, Malekzadeh R, Malta D, Manafi N, Mansournia M, Mantovani L, Marz W, Mashamba-Thompson T, Massenburg B, Mate K, McAlinden C, McGrath J, Mehta V, Meier T, Meles H, Melese A, Memiah P, Memish Z, Mendoza W, Mengistu D, Mengistu G, Meretoja A, Meretoja T, Mestrovic T, Miazgowski B, Miazgowski T, Miller T, Mini G, Mirrakhimov E, Moazen B, Mohajer B, Mezerji N, Mohammadi M, Mohammadi-Khanaposhtani M, Mohammadibakhsh R, Mohammadnia-Afrouzi M, Mohammed S, Mohebi F, Mokdad A, Monasta L, Mondello S, Moodley Y, Moosazadeh M, Moradi G, Moradi-Lakeh M, Moradinazar M, Moraga P, Velasquez I, Morrison S, Mousavi S, Muhammed O, Muruet W, Musa K, Mustafa G, Naderi M, Nagel G, Naheed A, Naik G, Najafi F, Nangia V, Negoi I, Negoi R, Newton C, Ngunjiri J, Nguyen C, Nguyen L, Ningrum D, Nirayo Y, Nixon M, Norrving B, Noubiap J, Shiadeh M, Nyasulu P, Ogbo F, Oh I, Olagunju A, Olagunju T, Olivares P, Onwujekwe O, Oren E, Owolabi M, Mahesh P, Pakpour A, Pan W, Panda-Jonas S, Pandian J, Patel S, Pereira D, Petzold M, Pillay J, Piradov M, Polanczyk G, Polinder S, Postma M, Poulton R, Poustchi H, Prakash S, Prakash V, Qorbani M, Radfar A, Rafay A, Rafiei A, Rahim F, Rahimi-Movaghar V, Rahman M, Rajati F, Ram U, Ranta A, Rawaf D, Rawaf S, Reinig N, Reis C, Renzaho A, Resnikoff S, Rezaeian S, Rezai M, Gonzalez C, Roberts N, Roever L, Ronfani L, Roro E, Roshandel G, Rostami A, Sabbagh P, Sacco R, Sachdev P, Saddik B, Safari H, Safari-Faramani R, Safi S, Safiri S, Sagar R, Sahathevan R, Sahebkar A, Sahraian M, Salamati P, Zahabi S, Salimi Y, Samy A, Sanabria J, Santos I, Milicevic M, Sarrafzadegan N, Sartorius B, Sarvi S, Sathian B, Satpathy M, Sawant A, Sawhney M, Schneider I, Schottker B, Schwebel D, Seedat S, Sepanlou S, Shabaninejad H, Shafieesabet A, Shaikh M, Shakir R, Shams-Beyranvand M, Shamsizadeh M, Sharif M, Sharif-Alhoseini M, She J, Sheikh A, Sheth K, Shigematsu M, Shiri R, Shirkoohi R, Shiue I, Siabani S, Siddiqi T, Sigfusdottir I, Sigurvinsdottir R, Silberberg D, Silva J, Silveira D, Singh J, Sinha D, Skiadaresi E, Smith M, Sobaih B, Sobhani S, Soofi M, Soyiri I, Sposato L, Stein D, Stein M, Stokes M, Sufiyan M, Sykes B, Sylaja P, Tabares-Seisdedos R, Ao B, Tehrani-Banihashemi A, Temsah M, Temsah O, Thakur J, Thrift A, Topor-Madry R, Tortajada-Girbes M, Tovani-Palone M, Tran B, Tran K, Truelsen T, Tsadik A, Car L, Ukwaja K, Ullah I, Usman M, Uthman O, Valdez P, Vasankari T, Vasanthan R, Veisani Y, Venketasubramanian N, Violante F, Vlassov V, Vosoughi K, Vu G, Vujcic I, Wagnew F, Waheed Y, Wang Y, Weiderpass E, Weiss J, Whiteford H, Wijeratne T, Winkler A, Wiysonge C, Wolfe C, Xu G, Yadollahpour A, Yamada T, Yano Y, Yaseri M, Yatsuya H, Yimer E, Yip P, Yisma E, Yonemoto N, Yousefifard M, Yu C, Zaidi Z, Bin Zaman S, Zamani M, Zandian H, Zare Z, Zhang Y, Zodpey S, Naghavi M, Murray C, Vos T, GBD 2016 Neurology Collaborators, Bill & Melinda Gates Foundation, VU University medical center, Feigin V.L., Nichols E., Alam T., Bannick M.S., Beghi E., Blake N., Culpepper W.J., Dorsey E.R., Elbaz A., Ellenbogen R.G., Fisher J.L., Fitzmaurice C., Giussani G., Glennie L., James S.L., Johnson C.O., Kassebaum N.J., Logroscino G., Marin B., Mountjoy-Venning W.C., Nguyen M., Ofori-Asenso R., Patel A.P., Piccininni M., Roth G.A., Steiner T.J., Stovner L.J., Szoeke C.E.I., Theadom A., Vollset S.E., Wallin M.T., Wright C., Zunt J.R., Abbasi N., Abd-Allah F., Abdelalim A., Abdollahpour I., Aboyans V., Abraha H.N., Acharya D., Adamu A.A., Adebayo O.M., Adeoye A.M., Adsuar J.C., Afarideh M., Agrawal S., Ahmadi A., Ahmed M.B., Aichour A.N., Aichour I., Aichour M.T.E., Akinyemi R.O., Akseer N., Al-Eyadhy A., Al-Shahi Salman R., Alahdab F., Alene K.A., Aljunid S.M., Altirkawi K., Alvis-Guzman N., Anber N.H., Antonio C.A.T., Arabloo J., Aremu O., Arnlov J., Asayesh H., Asghar R.J., Atalay H.T., Awasthi A., Ayala Quintanilla B.P., Ayuk T.B., Badawi A., Banach M., Banoub J.A.M., Barboza M.A., Barker-Collo S.L., Barnighausen T.W., Baune B.T., Bedi N., Behzadifar M., Bejot Y., Bekele B.B., Belachew A.B., Bennett D.A., Bensenor I.M., Berhane A., Beuran M., Bhattacharyya K., Bhutta Z.A., Biadgo B., Bijani A., Bililign N., Bin Sayeed M.S., Blazes C.K., Brayne C., Butt Z.A., Campos-Nonato I.R., Cantu-Brito C., Car M., Cardenas R., Carrero J.J., Carvalho F., Castaneda-Orjuela C.A., Castro F., Catala-Lopez F., Cerin E., Chaiah Y., Chang J.-C., Chatziralli I., Chiang P.P.-C., Christensen H., Christopher D.J., Cooper C., Cortesi P.A., Costa V.M., Criqui M.H., Crowe C.S., Damasceno A.A.M., Daryani A., De la Cruz-Gongora V., De La Hoz F.P., De Leo D., Degefa M.G., Demoz G.T., Deribe K., Dharmaratne S.D., Diaz D., Dinberu M.T., Djalalinia S., Doku D.T., Dubey M., Dubljanin E., Duken E.E., Edvardsson D., El-Khatib Z., Endres M., Endries A.Y., Eskandarieh S., Esteghamati A., Esteghamati S., Farhadi F., Faro A., Farzadfar F., Farzaei M.H., Fatima B., Fereshtehnejad S.-M., Fernandes E., Feyissa G.T., Filip I., Fischer F., Fukumoto T., Ganji M., Gankpe F.G., Garcia-Gordillo M.A., Gebre A.K., Gebremichael T.G., Gelaw B.K., Geleijnse J.M., Geremew D., Gezae K.E., Ghasemi-Kasman M., Gidey M.Y., Gill P.S., Gill T.K., Gnedovskaya E.V., Goulart A.C., Grada A., Grosso G., Guo Y., Gupta R., Haagsma J.A., Hagos T.B., Haj-Mirzaian A., Hamadeh R.R., Hamidi S., Hankey G.J., Hao Y., Haro J.M., Hassankhani H., Hassen H.Y., Havmoeller R., Hay S.I., Hegazy M.I., Heidari B., Henok A., Heydarpour F., Hoang C.L., Hole M.K., Homaie Rad E., Hosseini S.M., Hu G., Igumbor E.U., Ilesanmi O.S., Irvani S.S.N., Islam S.M.S., Jakovljevic M., Javanbakht M., Jha R.P., Jobanputra Y.B., Jonas J.B., Jozwiak J.J., Jurisson M., Kahsay A., Kalani R., Kalkonde Y., Kamil T.A., Kanchan T., Karami M., Karch A., Karimi N., Kasaeian A., Kassa T.D., Kassa Z.Y., Kaul A., Kefale A.T., Keiyoro P.N., Khader Y.S., Khafaie M.A., Khalil I.A., Khan E.A., Khang Y.-H., Khazaie H., Kiadaliri A.A., Kiirithio D.N., Kim A.S., Kim D., Kim Y.-E., Kim Y.J., Kisa A., Kokubo Y., Koyanagi A., Krishnamurthi R.V., Kuate Defo B., Kucuk Bicer B., Kumar M., Lacey B., Lafranconi A., Lansingh V.C., Latifi A., Leshargie C.T., Li S., Liao Y., Linn S., Lo W.D., Lopez J.C.F., Lorkowski S., Lotufo P.A., Lucas R.M., Lunevicius R., Mackay M.T., Mahotra N.B., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Malta D.C., Manafi N., Mansournia M.A., Mantovani L.G., Marz W., Mashamba-Thompson T.P., Massenburg B.B., Mate K.K.V., McAlinden C., McGrath J.J., Mehta V., Meier T., Meles H.G., Melese A., Memiah P.T.N., Memish Z.A., Mendoza W., Mengistu D.T., Mengistu G., Meretoja A., Meretoja T.J., Mestrovic T., Miazgowski B., Miazgowski T., Miller T.R., Mini G.K., Mirrakhimov E.M., Moazen B., Mohajer B., Mohammad Gholi Mezerji N., Mohammadi M., Mohammadi-Khanaposhtani M., Mohammadibakhsh R., Mohammadnia-Afrouzi M., Mohammed S., Mohebi F., Mokdad A.H., Monasta L., Mondello S., Moodley Y., Moosazadeh M., Moradi G., Moradi-Lakeh M., Moradinazar M., Moraga P., Moreno Velasquez I., Morrison S.D., Mousavi S.M., Muhammed O.S., Muruet W., Musa K.I., Mustafa G., Naderi M., Nagel G., Naheed A., Naik G., Najafi F., Nangia V., Negoi I., Negoi R.I., Newton C.R.J., Ngunjiri J.W., Nguyen C.T., Nguyen L.H., Ningrum D.N.A., Nirayo Y.L., Nixon M.R., Norrving B., Noubiap J.J., Nourollahpour Shiadeh M., Nyasulu P.S., Ogbo F.A., Oh I.-H., Olagunju A.T., Olagunju T.O., Olivares P.R., Onwujekwe O.E., Oren E., Owolabi M.O., A M.P., Pakpour A.H., Pan W.-H., Panda-Jonas S., Pandian J.D., Patel S.K., Pereira D.M., Petzold M., Pillay J.D., Piradov M.A., Polanczyk G.V., Polinder S., Postma M.J., Poulton R., Poustchi H., Prakash S., Prakash V., Qorbani M., Radfar A., Rafay A., Rafiei A., Rahim F., Rahimi-Movaghar V., Rahman M., Rahman M.H.U., Rahman M.A., Rajati F., Ram U., Ranta A., Rawaf D.L., Rawaf S., Reinig N., Reis C., Renzaho A.M.N., Resnikoff S., Rezaeian S., Rezai M.S., Rios Gonzalez C.M., Roberts N.L.S., Roever L., Ronfani L., Roro E.M., Roshandel G., Rostami A., Sabbagh P., Sacco R.L., Sachdev P.S., Saddik B., Safari H., Safari-Faramani R., Safi S., Safiri S., Sagar R., Sahathevan R., Sahebkar A., Sahraian M.A., Salamati P., Salehi Zahabi S., Salimi Y., Samy A.M., Sanabria J., Santos I.S., Santric Milicevic M.M., Sarrafzadegan N., Sartorius B., Sarvi S., Sathian B., Satpathy M., Sawant A.R., Sawhney M., Schneider I.J.C., Schottker B., Schwebel D.C., Seedat S., Sepanlou S.G., Shabaninejad H., Shafieesabet A., Shaikh M.A., Shakir R.A., Shams-Beyranvand M., Shamsizadeh M., Sharif M., Sharif-Alhoseini M., She J., Sheikh A., Sheth K.N., Shigematsu M., Shiri R., Shirkoohi R., Shiue I., Siabani S., Siddiqi T.J., Sigfusdottir I.D., Sigurvinsdottir R., Silberberg D.H., Silva J.P., Silveira D.G.A., Singh J.A., Sinha D.N., Skiadaresi E., Smith M., Sobaih B.H., Sobhani S., Soofi M., Soyiri I.N., Sposato L.A., Stein D.J., Stein M.B., Stokes M.A., Sufiyan M.B., Sykes B.L., Sylaja P., Tabares-Seisdedos R., Te Ao B.J., Tehrani-Banihashemi A., Temsah M.-H., Temsah O., Thakur J.S., Thrift A.G., Topor-Madry R., Tortajada-Girbes M., Tovani-Palone M.R., Tran B.X., Tran K.B., Truelsen T.C., Tsadik A.G., Tudor Car L., Ukwaja K.N., Ullah I., Usman M.S., Uthman O.A., Valdez P.R., Vasankari T.J., Vasanthan R., 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Ofori-Asenso, R, Patel, A, Piccininni, M, Roth, G, Steiner, T, Stovner, L, Szoeke, C, Theadom, A, Vollset, S, Wallin, M, Wright, C, Zunt, J, Abbasi, N, Abd-Allah, F, Abdelalim, A, Abdollahpour, I, Aboyans, V, Abraha, H, Acharya, D, Adamu, A, Adebayo, O, Adeoye, A, Adsuar, J, Afarideh, M, Agrawal, S, Ahmadi, A, Ahmed, M, Aichour, A, Aichour, I, Aichour, M, Akinyemi, R, Akseer, N, Al-Eyadhy, A, Al-Shahi Salman, R, Alahdab, F, Alene, K, Aljunid, S, Altirkawi, K, Alvis-Guzman, N, Anber, N, Antonio, C, Arabloo, J, Aremu, O, Ärnlöv, J, Asayesh, H, Asghar, R, Atalay, H, Awasthi, A, Ayala Quintanilla, B, Ayuk, T, Badawi, A, Banach, M, Banoub, J, Barboza, M, Barker-Collo, S, Bärnighausen, T, Baune, B, Bedi, N, Behzadifar, M, Béjot, Y, Bekele, B, Belachew, A, Bennett, D, Bensenor, I, Berhane, A, Beuran, M, Bhattacharyya, K, Bhutta, Z, Biadgo, B, Bijani, A, Bililign, N, Bin Sayeed, M, Blazes, C, Brayne, C, Butt, Z, Campos-Nonato, I, Cantu-Brito, C, Car, M, Cárdenas, R, Carrero, J, Carvalho, F, Castañeda-Orjuela, C, Castro, F, Catalá-López, F, Cerin, E, Chaiah, Y, Chang, J, Chatziralli, I, Chiang, P, Christensen, H, Christopher, D, Cooper, C, Cortesi, P, Costa, V, Criqui, M, Crowe, C, Damasceno, A, Daryani, A, De la Cruz-Góngora, V, De la Hoz, F, De Leo, D, Demoz, G, Deribe, K, Dharmaratne, S, Diaz, D, Dinberu, M, Djalalinia, S, Doku, D, Dubey, M, Dubljanin, E, Duken, E, Edvardsson, D, El-Khatib, Z, Endres, M, Endries, A, Eskandarieh, S, Esteghamati, A, Esteghamati, S, Farhadi, F, Faro, A, Farzadfar, F, Farzaei, M, Fatima, B, Fereshtehnejad, S, Fernandes, E, Feyissa, G, Filip, I, Fischer, F, Fukumoto, T, Ganji, M, Gankpe, F, Garcia-Gordillo, M, Gebre, A, Gebremichael, T, Gelaw, B, Geleijnse, J, Geremew, D, Gezae, K, Ghasemi-Kasman, M, Gidey, M, Gill, P, Gill, T, Girma, E, Gnedovskaya, E, Goulart, A, Grada, A, Grosso, G, Guo, Y, Gupta, R, Haagsma, J, Hagos, T, Haj-Mirzaian, A, Hamadeh, R, Hamidi, S, Hankey, G, Hao, Y, Haro, J, Hassankhani, H, Hassen, H, Havmoeller, R, Hay, S, Hegazy, M, Heidari, B, Henok, A, Heydarpour, F, Hoang, C, Hole, M, Homaie Rad, E, Hosseini, S, Hu, G, Igumbor, E, Ilesanmi, O, Irvani, S, Islam, S, Jakovljevic, M, Javanbakht, M, Jha, R, Jobanputra, Y, Jonas, J, Jozwiak, J, Jürisson, M, Kahsay, A, Kalani, R, Kalkonde, Y, Kamil, T, Kanchan, T, Karami, M, Karch, A, Karimi, N, Kasaeian, A, Kassa, T, Kassa, Z, Kaul, A, Kefale, A, Keiyoro, P, Khader, Y, Khafaie, M, Khalil, I, Khan, E, Khang, Y, Khazaie, H, Kiadaliri, A, Kiirithio, D, Kim, A, Kim, D, Kim, Y, Kisa, A, Kokubo, Y, Koyanagi, A, Krishnamurthi, R, Kuate Defo, B, Kucuk Bicer, B, Kumar, M, Lacey, B, Lafranconi, A, Lansingh, V, Latifi, A, Leshargie, C, Li, S, Liao, Y, Linn, S, Lo, W, Lopez, J, Lorkowski, S, Lotufo, P, Lucas, R, Lunevicius, R, Mackay, M, Mahotra, N, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Malta, D, Manafi, N, Mansournia, M, Mantovani, L, März, W, Mashamba-Thompson, T, Massenburg, B, Mate, K, Mcalinden, C, Mcgrath, J, Mehta, V, Meier, T, Meles, H, Melese, A, Memiah, P, Memish, Z, Mendoza, W, Mengistu, D, Mengistu, G, Meretoja, A, Meretoja, T, Mestrovic, T, Miazgowski, B, Miazgowski, T, Miller, T, Mini, G, Mirrakhimov, E, Moazen, B, Mohajer, B, Mohammad Gholi Mezerji, N, Mohammadi, M, Mohammadi-Khanaposhtani, M, Mohammadibakhsh, R, Mohammadnia-Afrouzi, M, Mohammed, S, Mohebi, F, Mokdad, A, Monasta, L, Mondello, S, Moodley, Y, Moosazadeh, M, Moradi, G, Moradi-Lakeh, M, Moradinazar, M, Moraga, P, Moreno Velásquez, I, Morrison, S, Mousavi, S, Muhammed, O, Muruet, W, Musa, K, Mustafa, G, Naderi, M, Nagel, G, Naheed, A, Naik, G, Najafi, F, Nangia, V, Negoi, I, Negoi, R, Newton, C, Ngunjiri, J, Nguyen, C, Nguyen, L, Ningrum, D, Nirayo, Y, Nixon, M, Norrving, B, Noubiap, J, Nourollahpour Shiadeh, M, Nyasulu, P, Ogah, O, Oh, I, Olagunju, A, Olagunju, T, Olivares, P, Onwujekwe, O, Oren, E, Owolabi, M, Pa, M, Pakpour, A, Pan, W, Panda-Jonas, S, Pandian, J, Patel, S, Pereira, D, Petzold, M, Pillay, J, Piradov, M, Polanczyk, G, Polinder, S, Postma, M, Poulton, R, Poustchi, H, Prakash, S, Prakash, V, Qorbani, M, Radfar, A, Rafay, A, Rafiei, A, Rahim, F, Rahimi-Movaghar, V, Rahman, M, Rajati, F, Ram, U, Ranta, A, Rawaf, D, Rawaf, S, Reinig, N, Reis, C, Renzaho, A, Resnikoff, S, Rezaeian, S, Rezai, M, Rios González, C, Roberts, N, Roever, L, Ronfani, L, Roro, E, Roshandel, G, Rostami, A, Sabbagh, P, Sacco, R, Sachdev, P, Saddik, B, Safari, H, Safari-Faramani, R, Safi, S, Safiri, S, Sagar, R, Sahathevan, R, Sahebkar, A, Sahraian, M, Salamati, P, Salehi Zahabi, S, Salimi, Y, Samy, A, Sanabria, J, Santos, I, Santric Milicevic, M, Sarrafzadegan, N, Sartorius, B, Sarvi, S, Sathian, B, Satpathy, M, Sawant, A, Sawhney, M, Schneider, I, Schöttker, B, Schwebel, D, Seedat, S, Sepanlou, S, Shabaninejad, H, Shafieesabet, A, Shaikh, M, Shakir, R, Shams-Beyranvand, M, Shamsizadeh, M, Sharif, M, Sharif-Alhoseini, M, She, J, Sheikh, A, Sheth, K, Shigematsu, M, Shiri, R, Shirkoohi, R, Shiue, I, Siabani, S, Siddiqi, T, Sigfusdottir, I, Sigurvinsdottir, R, Silberberg, D, Silva, J, Silveira, D, Singh, J, Sinha, D, Skiadaresi, E, Smith, M, Sobaih, B, Sobhani, S, Soofi, M, Soyiri, I, Sposato, L, Stein, D, Stein, M, Stokes, M, Sufiyan, M, Sykes, B, Sylaja, P, Tabarés-Seisdedos, R, Te Ao, B, Tehrani-Banihashemi, A, Temsah, M, Temsah, O, Thakur, J, Thrift, A, Topor-Madry, R, Tortajada-Girbés, M, Tovani-Palone, M, Tran, B, Tran, K, Truelsen, T, Tsadik, A, Tudor Car, L, Ukwaja, K, Ullah, I, Usman, M, Uthman, O, Valdez, P, Vasankari, T, Vasanthan, R, Veisani, Y, Venketasubramanian, N, Violante, F, Vlassov, V, Vosoughi, K, Vu, G, Vujcic, I, Wagnew, F, Waheed, Y, Wang, Y, Weiderpass, E, Weiss, J, Whiteford, H, Wijeratne, T, Winkler, A, Wiysonge, C, Wolfe, C, Xu, G, Yadollahpour, A, Yamada, T, Yano, Y, Yaseri, M, Yatsuya, H, Yimer, E, Yip, P, Yisma, E, Yonemoto, N, Yousefifard, M, Yu, C, Zaidi, Z, Zaman, S, Zamani, M, Zandian, H, Zare, Z, Zhang, Y, Zodpey, S, Naghavi, M, Murray, C, Vos, T, PharmacoTherapy, -Epidemiology and -Economics, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Lee Kong Chian School of Medicine (LKCMedicine), Clinicum, Department of Neurosciences, Neurologian yksikkö, Department of Surgery, University of Helsinki, II kirurgian klinikka, and HUS Comprehensive Cancer Center

Subjects
Dánarmein, Male, Epidemiology, Diseases, Malalties cerebrals, Global Burden of Disease, Disability Evaluation, 0302 clinical medicine, Case fatality rate, Psychology, Konur, Cause of death, Aged, 80 and over, education.field_of_study, Incidence, Men, Taugavísindi, ddc, 3. Good health, Sálfræði, World health, Muerte, Neurology, GBD 2016 Neurology Collaborators, Brain diseases, Quality-Adjusted Life Years, Alzheimer disease, Carga global de enfermedades, Nervous system, medicine.medical_specialty, Global burden of diseases, Lífsgæði, Article, 03 medical and health sciences, Health Sciences, Humans, Women, education, Trastornos neurológicos, VLAG, Aged, Science & Technology, 3112 Neurosciences, Global Burden of Diseases, 030104 developmental biology, Years of potential life lost, Επιστήμες Υγείας, Dementia, Human medicine, Neurosciences & Neurology, Neurology (clinical), Clinical Medicine, 1109 Neurosciences, Neurological disorders, 030217 neurology & neurosurgery, dementia, RC, 0301 basic medicine, Pediatrics, Dánartíðni, Nutrition and Disease, 3124 Neurology and psychiatry, Disease Study, Taugasjúkdómar, Risk Factors, Voeding en Ziekte, Cause of Death, Global health, Prevalence, Causes of death, Public health, Mortality rate, Mental Disorders, Age Factors, Public Health, Global Health, Social Medicine and Epidemiology, Middle Aged, neurologic disease, Death, Lýðheilsa, Female, Life Sciences & Biomedicine, Quality of life, Adult, Population, Clinical Neurology, Sex Factors, medicine, Life Science, Disability-adjusted life year, Medicine [Science], Mortality, Psychiatry, Disease burden, Neurology & Neurosurgery, burden of neurological disorders, Faraldsfræði, business.industry, Klinisk medicin, Causes de la mort, 1103 Clinical Sciences, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Socioeconomic Factors, Karlar, global disease burden, Nervous System Diseases, Cause of death/trends, business
Abstract

Publisher´s version (útgefin grein)., Background Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders.Methods We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer’s disease and other dementias, Parkinson’s disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach.Findings Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer’s and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer’s disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable).Interpretation Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies., ROA is funded by the National Institutes of Health (U01HG010273). SMA acknowledges the International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia and Department of Health Policy and Management, Faculty of Public Health, Kuwait University for the approval and support to participate in this research project. AAw acknowledges funding support from Department of Science and Technology, Government of India, New Delhi, through INSPIRE Faculty scheme. TBA acknowledges partial funding from the Institute of Medical Research and Medicinal Plant Studies. ABa is supported by the Public Health Agency of Canada. TWB was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor Award, funded by the Federal Ministry of Education and Research. MSBS acknowledges support from the Australian Government Research and Training Program scholarship for a PhD degree at the Australian National University, Australia. JJC is supported by the Swedish Heart and Lung Foundation. FCar is supported by the European Union (FEDER funds POCI/01/0145/FEDER/007728 and POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundacao para a Ciencia e a Tecnologia and Ministerio da Educacao e Ciencia) under the Partnership Agreements PT2020 UID/MULTI/04378/2013 and PT2020UID/QUI/50006/2013. EC is supported by an Australian Research Council Future Fellowship (FT3 140100085). KD is supported by a Wellcome Trust [Grant Number 201900] as part of his International Intermediate Fellowship. EF is supported by the European Union (FEDER funds POCI/01/0145/FEDER/007728 and POCI/01/0145/FEDER/007265) and National Funds (FCT/MEC, Fundacao para a Ciencia e a Tecnologia and Ministerio da Educacao e Ciencia) under the Partnership Agreements PT2020 UID/MULTI/04378/2013 and PT2020UID/QUI/50006/2013. SMSI is funded by the Institute for Physical Activity and Nutrition (IPAN), Deakin University and received funding from High Blood Pressure Research Council of Australia. YKa is a DBT/Wellcome Trust India Alliance Fellow in Public Health. YJK is supported by the Office of Research and Innovation at Xiamen University Malaysia. BL acknowledges funding from the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre. WDL is supported in part by U10NS086484 NINDS. SLo is funded by the German Federal Ministry of Education and Research (nutriCARD, grant agreement number 01EA1411A). RML is supported by a National Health and Medical Research Council (NHMRC) of Australia Senior Research Fellowship. AMa and the Imperial College London are grateful for support from the NW London NIHR Collaboration for Leadership in Applied Health Research and Care. JJM is supported by the Danish National Research Foundation (Niels Bohr Professorship), and the John Cade Fellowship (APP1056929) from NHMRC. TMei acknowledges additional institutional support from the Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Jena-Halle-Leipzig. IMV is supported by the Sistema Nacional de Investigacion (Panama). MOO is supported by SIREN U54 U54HG007479 and SIBS Genomics R01NS107900 grants. AMS was supported by a fellowship from the Egyptian Fulbright Mission Program. MMSM acknowledges the support from the Ministry of Education, Science and Technological Development, Republic of Serbia (contract no 175087). AShe is supported by Health Data Research UK. MBS' work on traumatic brain injury is supported by grants NIH U01 NS086090 (PI G Manley) from the National Institutes of Health (NIH) and DoD W81XWH-14-2-0176 (PI G Manley) from the United States Department of Defense. RTS is supported in part by grant number PROMETEOII/2015/021 from Generalitat Valenciana and the national grant PI17/00719 from ISCIIIFEDER. AGT was supported by a Fellowship from the NHMRC (Australia; 1042600. KBT acknowledges funding supports from the Maurice Wilkins Centre for Biodiscovery, Cancer Society of New Zealand, Health Research Council, Gut Cancer Foundation, and the University of Auckland. CY acknowledges support from the National Natural Science Foundation of China (grant number 81773552) and the Chinese NSFC International Cooperation and Exchange Program (grant number 71661167007)., "Peer Reviewed"

Published
2019
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16. A Cross Sectional Study to Identify Perceived Barriers and Facilitators to Physical Activity and Exercise Participation of People with Post Stroke Depression.

Author

Ratnakumar, Reshna, Javed, Jasrah, Senthil, K., and Vasanthan, R.

Subjects
COGNITION disorders, STROKE, CROSS-sectional method, RESEARCH methodology, PHYSICAL activity, SEX distribution, MENTAL depression, EXERCISE, DESCRIPTIVE statistics, QUESTIONNAIRES, CHI-squared test, QUALITY of life, DRUGS, JUDGMENT sampling, PATIENT compliance, ANXIETY, LANGUAGE disorders
Abstract

Background: Physical activity and exercises after stroke may prevent the disability and stroke recurrence; yet, psychological impairments like depression may inhibit post stroke exercise and subsequently limit recovery. Though it remains less clear how best is to encourage exercise uptake by individuals with depression after stroke. Objective: The objective of this study was to identify the perceived barriers and facilitators to physical activity and exercise participation among post stroke depressed individuals. Methods: Descriptive cross-sectional design was adopted using purposive sampling of stroke survivors. Fifty stroke survivors were screened and identified for depression using HAM-D.25 depressed and 25 non- depressed stroke survivors have been grouped into active and inactive groups based on exercise and physical activity guidelines. IPAQ scale has grouped them into physically active and physically inactive based on 3 METs. Using the EBBS scale, the percentage of positive responses for different domains for benefit and barrier scale was calculated. The significant difference in the percentage of response in barrier and benefit domains was analyzed using Chi-square test. Results: There was significant difference in percentage of response in each benefit domain of EBBS between depressed and non- depressed active groups. Similarly there was significant difference in percentage of response in each barrier domain of EBBS between depressed and non depressed inactive groups. Ten major perceived barriers were reported in depressed non-active group in which exercising cause fatigue (100%) was the highly reported response. Conclusion: The study concluded that interventions could be designed for promoting the facilitators more and addressing the barriers to exercise and time management which is likely to reduce the healthcare costs of management of stroke. [ABSTRACT FROM AUTHOR]

Published
2022
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20. Effect of Lumbopelvic Manipulation Versus Tibiofemoral Mobilization on Pain and Quality of Life in Patellofemoral Pain Syndrome.

Author

Kumar, R. Mukesh, Shereief, Benazir, and Vasanthan, R.

Subjects
PLICA syndrome treatment, EXPERIMENTAL design, KRUSKAL-Wallis Test, KNEE pain, CLINICAL trials, MANN Whitney U Test, PRE-tests & post-tests, MANIPULATION therapy, PHYSICAL mobility, QUALITY of life, DESCRIPTIVE statistics, TIBIA, FEMUR, LUMBAR vertebrae, JUDGMENT sampling, PELVIS, PAIN management
Published
2022
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21. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Feigin, V.L. Nichols, E. Alam, T. Bannick, M.S. Beghi, E. Blake, N. Culpepper, W.J. Dorsey, E.R. Elbaz, A. Ellenbogen, R.G. Fisher, J.L. Fitzmaurice, C. Giussani, G. Glennie, L. James, S.L. Johnson, C.O. Kassebaum, N.J. Logroscino, G. Marin, B. Mountjoy-Venning, W.C. Nguyen, M. Ofori-Asenso, R. Patel, A.P. Piccininni, M. Roth, G.A. Steiner, T.J. Stovner, L.J. Szoeke, C.E.I. Theadom, A. Vollset, S.E. Wallin, M.T. Wright, C. Zunt, J.R. Abbasi, N. Abd-Allah, F. Abdelalim, A. Abdollahpour, I. Aboyans, V. Abraha, H.N. Acharya, D. Adamu, A.A. Adebayo, O.M. Adeoye, A.M. Adsuar, J.C. Afarideh, M. Agrawal, S. Ahmadi, A. Ahmed, M.B. Aichour, A.N. Aichour, I. Aichour, M.T.E. Akinyemi, R.O. Akseer, N. Al-Eyadhy, A. Al-Shahi Salman, R. Alahdab, F. Alene, K.A. Aljunid, S.M. Altirkawi, K. Alvis-Guzman, N. Anber, N.H. Antonio, C.A.T. Arabloo, J. Aremu, O. Ärnlöv, J. Asayesh, H. Asghar, R.J. Atalay, H.T. Awasthi, A. Ayala Quintanilla, B.P. Ayuk, T.B. Badawi, A. Banach, M. Banoub, J.A.M. Barboza, M.A. Barker-Collo, S.L. Bärnighausen, T.W. Baune, B.T. Bedi, N. Behzadifar, M. Behzadifar, M. Béjot, Y. Bekele, B.B. Belachew, A.B. Bennett, D.A. Bensenor, I.M. Berhane, A. Beuran, M. Bhattacharyya, K. Bhutta, Z.A. Biadgo, B. Bijani, A. Bililign, N. Bin Sayeed, M.S. Blazes, C.K. Brayne, C. Butt, Z.A. Campos-Nonato, I.R. Cantu-Brito, C. Car, M. Cárdenas, R. Carrero, J.J. Carvalho, F. Castañeda-Orjuela, C.A. Castro, F. Catalá-López, F. Cerin, E. Chaiah, Y. Chang, J.-C. Chatziralli, I. Chiang, P.P.-C. Christensen, H. Christopher, D.J. Cooper, C. Cortesi, P.A. Costa, V.M. Criqui, M.H. Crowe, C.S. Damasceno, A.A.M. Daryani, A. De la Cruz-Góngora, V. De La Hoz, F.P. De Leo, D. Degefa, M.G. Demoz, G.T. Deribe, K. Dharmaratne, S.D. Diaz, D. Dinberu, M.T. Djalalinia, S. Doku, D.T. Dubey, M. Dubljanin, E. Duken, E.E. Edvardsson, D. El-Khatib, Z. Endres, M. Endries, A.Y. Eskandarieh, S. Esteghamati, A. Esteghamati, S. Farhadi, F. Faro, A. Farzadfar, F. Farzaei, M.H. Fatima, B. Fereshtehnejad, S.-M. Fernandes, E. Feyissa, G.T. Filip, I. Fischer, F. Fukumoto, T. Ganji, M. Gankpe, F.G. Garcia-Gordillo, M.A. Gebre, A.K. Gebremichael, T.G. Gelaw, B.K. Geleijnse, J.M. Geremew, D. Gezae, K.E. Ghasemi-Kasman, M. Gidey, M.Y. Gill, P.S. Gill, T.K. Gnedovskaya, E.V. Goulart, A.C. Grada, A. Grosso, G. Guo, Y. Gupta, R. Gupta, R. Haagsma, J.A. Hagos, T.B. Haj-Mirzaian, A. Haj-Mirzaian, A. Hamadeh, R.R. Hamidi, S. Hankey, G.J. Hao, Y. Haro, J.M. Hassankhani, H. Hassen, H.Y. Havmoeller, R. Hay, S.I. Hegazy, M.I. Heidari, B. Henok, A. Heydarpour, F. Hoang, C.L. Hole, M.K. Homaie Rad, E. Hosseini, S.M. Hu, G. Igumbor, E.U. Ilesanmi, O.S. Irvani, S.S.N. Islam, S.M.S. Jakovljevic, M. Javanbakht, M. Jha, R.P. Jobanputra, Y.B. Jonas, J.B. Józwiak, J.J. Jürisson, M. Kahsay, A. Kalani, R. Kalkonde, Y. Kamil, T.A. Kanchan, T. Karami, M. Karch, A. Karimi, N. Kasaeian, A. Kassa, T.D. Kassa, Z.Y. Kaul, A. Kefale, A.T. Keiyoro, P.N. Khader, Y.S. Khafaie, M.A. Khalil, I.A. Khan, E.A. Khang, Y.-H. Khazaie, H. Kiadaliri, A.A. Kiirithio, D.N. Kim, A.S. Kim, D. Kim, Y.-E. Kim, Y.J. Kisa, A. Kokubo, Y. Koyanagi, A. Krishnamurthi, R.V. Kuate Defo, B. Kucuk Bicer, B. Kumar, M. Lacey, B. Lafranconi, A. Lansingh, V.C. Latifi, A. Leshargie, C.T. Li, S. Liao, Y. Linn, S. Lo, W.D. Lopez, J.C.F. Lorkowski, S. Lotufo, P.A. Lucas, R.M. Lunevicius, R. Mackay, M.T. Mahotra, N.B. Majdan, M. Majdzadeh, R. Majeed, A. Malekzadeh, R. Malta, D.C. Manafi, N. Mansournia, M.A. Mantovani, L.G. März, W. Mashamba-Thompson, T.P. Massenburg, B.B. Mate, K.K.V. McAlinden, C. McGrath, J.J. Mehta, V. Meier, T. Meles, H.G. Melese, A. Memiah, P.T.N. Memish, Z.A. Mendoza, W. Mengistu, D.T. Mengistu, G. Meretoja, A. Meretoja, T.J. Mestrovic, T. Miazgowski, B. Miazgowski, T. Miller, T.R. Mini, G.K. Mirrakhimov, E.M. Moazen, B. Mohajer, B. Mohammad Gholi Mezerji, N. Mohammadi, M. Mohammadi-Khanaposhtani, M. Mohammadibakhsh, R. Mohammadnia-Afrouzi, M. Mohammed, S. Mohebi, F. Mokdad, A.H. Monasta, L. Mondello, S. Moodley, Y. Moosazadeh, M. Moradi, G. Moradi-Lakeh, M. Moradinazar, M. Moraga, P. Moreno Velásquez, I. Morrison, S.D. Mousavi, S.M. Muhammed, O.S. Muruet, W. Musa, K.I. Mustafa, G. Naderi, M. Nagel, G. Naheed, A. Naik, G. Najafi, F. Nangia, V. Negoi, I. Negoi, R.I. Newton, C.R.J. Ngunjiri, J.W. Nguyen, C.T. Nguyen, L.H. Ningrum, D.N.A. Nirayo, Y.L. Nixon, M.R. Norrving, B. Noubiap, J.J. Nourollahpour Shiadeh, M. Nyasulu, P.S. Ogbo, F.A. Oh, I.-H. Olagunju, A.T. Olagunju, T.O. Olivares, P.R. Onwujekwe, O.E. Oren, E. Owolabi, M.O. A, M.P. Pakpour, A.H. Pan, W.-H. Panda-Jonas, S. Pandian, J.D. Patel, S.K. Pereira, D.M. Petzold, M. Pillay, J.D. Piradov, M.A. Polanczyk, G.V. Polinder, S. Postma, M.J. Poulton, R. Poustchi, H. Prakash, S. Prakash, V. Qorbani, M. Radfar, A. Rafay, A. Rafiei, A. Rahim, F. Rahimi-Movaghar, V. Rahman, M. Rahman, M.H.U. Rahman, M.A. Rajati, F. Ram, U. Ranta, A. Rawaf, D.L. Rawaf, S. Reinig, N. Reis, C. Renzaho, A.M.N. Resnikoff, S. Rezaeian, S. Rezai, M.S. Rios González, C.M. Roberts, N.L.S. Roever, L. Ronfani, L. Roro, E.M. Roshandel, G. Rostami, A. Sabbagh, P. Sacco, R.L. Sachdev, P.S. Saddik, B. Safari, H. Safari-Faramani, R. Safi, S. Safiri, S. Sagar, R. Sahathevan, R. Sahebkar, A. Sahraian, M.A. Salamati, P. Salehi Zahabi, S. Salimi, Y. Samy, A.M. Sanabria, J. Santos, I.S. Santric Milicevic, M.M. Sarrafzadegan, N. Sartorius, B. Sarvi, S. Sathian, B. Satpathy, M. Sawant, A.R. Sawhney, M. Schneider, I.J.C. Schöttker, B. Schwebel, D.C. Seedat, S. Sepanlou, S.G. Shabaninejad, H. Shafieesabet, A. Shaikh, M.A. Shakir, R.A. Shams-Beyranvand, M. Shamsizadeh, M. Sharif, M. Sharif-Alhoseini, M. She, J. Sheikh, A. Sheth, K.N. Shigematsu, M. Shiri, R. Shirkoohi, R. Shiue, I. Siabani, S. Siddiqi, T.J. Sigfusdottir, I.D. Sigurvinsdottir, R. Silberberg, D.H. Silva, J.P. Silveira, D.G.A. Singh, J.A. Sinha, D.N. Skiadaresi, E. Smith, M. Sobaih, B.H. Sobhani, S. Soofi, M. Soyiri, I.N. Sposato, L.A. Stein, D.J. Stein, M.B. Stokes, M.A. Sufiyan, M.B. Sykes, B.L. Sylaja, P. Tabarés-Seisdedos, R. Te Ao, B.J. Tehrani-Banihashemi, A. Temsah, M.-H. Temsah, O. Thakur, J.S. Thrift, A.G. Topor-Madry, R. Tortajada-Girbés, M. Tovani-Palone, M.R. Tran, B.X. Tran, K.B. Truelsen, T.C. Tsadik, A.G. Tudor Car, L. Ukwaja, K.N. Ullah, I. Usman, M.S. Uthman, O.A. Valdez, P.R. Vasankari, T.J. Vasanthan, R. Veisani, Y. Venketasubramanian, N. Violante, F.S. Vlassov, V. Vosoughi, K. Vu, G.T. Vujcic, I.S. Wagnew, F.S. Waheed, Y. Wang, Y.-P. Weiderpass, E. Weiss, J. Whiteford, H.A. Wijeratne, T. Winkler, A.S. Wiysonge, C.S. Wolfe, C.D.A. Xu, G. Yadollahpour, A. Yamada, T. Yano, Y. Yaseri, M. Yatsuya, H. Yimer, E.M. Yip, P. Yisma, E. Yonemoto, N. Yousefifard, M. Yu, C. Zaidi, Z. Zaman, S.B. Zamani, M. Zandian, H. Zare, Z. Zhang, Y. Zodpey, S. Naghavi, M. Murray, C.J.L. Vos, T. GBD 2016 Neurology Collaborators

Abstract

Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach. Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·6–46·1]), migraine (16·3% [11·7–20·8]), Alzheimer's and other dementias (10·4% [9·0–12·1]), and meningitis (7·9% [6·6–10·4]). For the combined neurological disorders, age-standardised DALY rates were significantly higher in males than in females (male-to-female ratio 1·12 [1·05–1·20]), but migraine, multiple sclerosis, and tension-type headache were more common and caused more burden in females, with male-to-female ratios of less than 0·7. The 84 risks quantified in GBD explain less than 10% of neurological disorder DALY burdens, except stroke, for which 88·8% (86·5–90·9) of DALYs are attributable to risk factors, and to a lesser extent Alzheimer's disease and other dementias (22·3% [11·8–35·1] of DALYs are risk attributable) and idiopathic epilepsy (14·1% [10·8–17·5] of DALYs are risk attributable). Interpretation: Globally, the burden of neurological disorders, as measured by the absolute number of DALYs, continues to increase. As populations are growing and ageing, and the prevalence of major disabling neurological disorders steeply increases with age, governments will face increasing demand for treatment, rehabilitation, and support services for neurological disorders. The scarcity of established modifiable risks for most of the neurological burden demonstrates that new knowledge is required to develop effective prevention and treatment strategies. Funding: Bill & Melinda Gates Foundation. © 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license

Published
2019

23. Retzius-sparing vs. non-Retzius-sparing robotic-assisted radical prostatectomies: A comparative analysis of oncological outcomes of over 500 patients at a tertiary referral centre

Author

Vasanthan, R., primary, Chopra, S., additional, Parekh, K., additional, Moschonas, D., additional, Kusuma, M., additional, Pavlakis, P., additional, Johnston, M., additional, Hicks, J., additional, Patil, K., additional, Perry, M., additional, and Eden, C., additional

Published
2019
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24. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.

Author

Grosso G., Rafiei A., Rahim F., Rahimi K., Rahimi-Movaghar V., Rahman M., Rahman M.A., Reis C., Remuzzi G., Renzaho A.M.N., Ricci S., Roberts N.L.S., Robinson S.R., Roever L., Roshandel G., Sabbagh P., Safari H., Safari S., Safiri S., Sahebkar A., Salehi Zahabi S., Samy A.M., Santalucia P., Santos I.S., Santos J.V., Santric Milicevic M.M., Sartorius B., Sawant A.R., Schutte A.E., Sepanlou S.G., Shafieesabet A., Shaikh M.A., Shams-Beyranvand M., Sheikh A., Sheth K.N., Shibuya K., Shigematsu M., Shin M.-J., Shiue I., Siabani S., Sobaih B.H., Sposato L.A., Sutradhar I., Sylaja P.A., Szoeke C.E.I., Te Ao B.J., Temsah M.-H., Temsah O., Thrift A.G., Tonelli M., Topor-Madry R., Tran B.X., Tran K.B., Truelsen T.C., Tsadik A.G., Ullah I., Uthman O.A., Vaduganathan M., Valdez P.R., Vasankari T.J., Vasanthan R., Venketasubramanian N., Vosoughi K., Vu G.T., Waheed Y., Weiderpass E., Weldegwergs K.G., Westerman R., Wolfe C.D.A., Wondafrash D.Z., Xu G., Yadollahpour A., Yamada T., Yatsuya H., Yimer E.M., Yonemoto N., Yousefifard M., Yu C., Zaidi Z., Zamani M., Zarghi A., Zhang Y., Zodpey S., Feigin V.L., Vos T., Murray C.J.L., Johnson C.O., Nguyen M., Roth G.A., Nichols E., Alam T., Abate D., Abd-Allah F., Abdelalim A., Abraha H.N., Abu-Rmeileh N.M., Adebayo O.M., Adeoye A.M., Agarwal G., Agrawal S., Aichour A.N., Aichour I., Aichour M.T.E., Alahdab F., Ali R., Alvis-Guzman N., Anber N.H., Anjomshoa M., Arabloo J., Arauz A., Arnlov J., Arora A., Awasthi A., Banach M., Barboza M.A., Barker-Collo S.L., Barnighausen T.W., Basu S., Belachew A.B., Belayneh Y.M., Bennett D.A., Bensenor I.M., Bhattacharyya K., Biadgo B., Bijani A., Bikbov B., Bin Sayeed M.S., Butt Z.A., Cahuana-Hurtado L., Carrero J.J., Carvalho F., Castaneda-Orjuela C.A., Castro F., Catala-Lopez F., Chaiah Y., Chiang P.P.-C., Choi J.-Y.J., Christensen H., Chu D.-T., Cortinovis M., Damasceno A.A.M., Dandona L., Dandona R., Daryani A., Davletov K., De Courten B., De la Cruz-Gongora V., Degefa M.G., Dharmaratne S.D., Diaz D., Dubey M., Duken E.E., Edessa D., Endres M., Faraon E.J.A., Farzadfar F., Fernandes E., Fischer F., Flor L.S., Ganji M., Gebre A.K., Gebremichael T.G., Geta B., Gezae K.E., Gill P.S., Gnedovskaya E.V., Gomez-Dantes H., Goulart A.C., Guo Y., Gupta R., Haj-Mirzaian A., Hamidi S., Hankey G.J., Hassen H.Y., Hay S.I., Hegazy M.I., Heidari B., Herial N.A., Hosseini M.A., Hostiuc S., Irvani S.S.N., Islam S.M.S., Jahanmehr N., Javanbakht M., Jha R.P., Jonas J.B., Jozwiak J.J., Jurisson M., Kahsay A., Kalani R., Kalkonde Y., Kamil T.A., Kanchan T., Karch A., Karimi N., Karimi-Sari H., Kasaeian A., Kassa T.D., Kazemeini H., Kefale A.T., Khader Y.S., Khalil I.A., Khan E.A., Khang Y.-H., Khubchandani J., Kim D., Kim Y.J., Kisa A., Kivimaki M., Koyanagi A., Krishnamurthi R.K., Anil Kumar G., Lafranconi A., Lewington S., Li S., Lo W.D., Lopez A.D., Lorkowski S., Lotufo P.A., Mackay M.T., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Manafi N., Mansournia M.A., Mehndiratta M.M., Mehta V., Mengistu G., Meretoja A., Meretoja T.J., Miazgowski B., Miazgowski T., Miller T.R., Mirrakhimov E.M., Mohajer B., Mohammad Y., Mohammadoo-Khorasani M., Mohammed S., Mohebi F., Mokdad A.H., Mokhayeri Y., Moradi G., Morawska L., Moreno Velasquez I., Mousavi S.M., Muhammed O.S.S., Muruet W., Naderi M., Naghavi M., Naik G., Nascimento B.R., Negoi R.I., Nguyen C.T., Nguyen L.H., Nirayo Y.L., Norrving B., Noubiap J.J., Ofori-Asenso R., Ogbo F.A., Olagunju A.T., Olagunju T.O., Owolabi M.O., Pandian J.D., Patel S., Perico N., Piradov M.A., Polinder S., Postma M.J., Poustchi H., Prakash V., Qorbani M., Grosso G., Rafiei A., Rahim F., Rahimi K., Rahimi-Movaghar V., Rahman M., Rahman M.A., Reis C., Remuzzi G., Renzaho A.M.N., Ricci S., Roberts N.L.S., Robinson S.R., Roever L., Roshandel G., Sabbagh P., Safari H., Safari S., Safiri S., Sahebkar A., Salehi Zahabi S., Samy A.M., Santalucia P., Santos I.S., Santos J.V., Santric Milicevic M.M., Sartorius B., Sawant A.R., Schutte A.E., Sepanlou S.G., Shafieesabet A., Shaikh M.A., Shams-Beyranvand M., Sheikh A., Sheth K.N., Shibuya K., Shigematsu M., Shin M.-J., Shiue I., Siabani S., Sobaih B.H., Sposato L.A., Sutradhar I., Sylaja P.A., Szoeke C.E.I., Te Ao B.J., Temsah M.-H., Temsah O., Thrift A.G., Tonelli M., Topor-Madry R., Tran B.X., Tran K.B., Truelsen T.C., Tsadik A.G., Ullah I., Uthman O.A., Vaduganathan M., Valdez P.R., Vasankari T.J., Vasanthan R., Venketasubramanian N., Vosoughi K., Vu G.T., Waheed Y., Weiderpass E., Weldegwergs K.G., Westerman R., Wolfe C.D.A., Wondafrash D.Z., Xu G., Yadollahpour A., Yamada T., Yatsuya H., Yimer E.M., Yonemoto N., Yousefifard M., Yu C., Zaidi Z., Zamani M., Zarghi A., Zhang Y., Zodpey S., Feigin V.L., Vos T., Murray C.J.L., Johnson C.O., Nguyen M., Roth G.A., Nichols E., Alam T., Abate D., Abd-Allah F., Abdelalim A., Abraha H.N., Abu-Rmeileh N.M., Adebayo O.M., Adeoye A.M., Agarwal G., Agrawal S., Aichour A.N., Aichour I., Aichour M.T.E., Alahdab F., Ali R., Alvis-Guzman N., Anber N.H., Anjomshoa M., Arabloo J., Arauz A., Arnlov J., Arora A., Awasthi A., Banach M., Barboza M.A., Barker-Collo S.L., Barnighausen T.W., Basu S., Belachew A.B., Belayneh Y.M., Bennett D.A., Bensenor I.M., Bhattacharyya K., Biadgo B., Bijani A., Bikbov B., Bin Sayeed M.S., Butt Z.A., Cahuana-Hurtado L., Carrero J.J., Carvalho F., Castaneda-Orjuela C.A., Castro F., Catala-Lopez F., Chaiah Y., Chiang P.P.-C., Choi J.-Y.J., Christensen H., Chu D.-T., Cortinovis M., Damasceno A.A.M., Dandona L., Dandona R., Daryani A., Davletov K., De Courten B., De la Cruz-Gongora V., Degefa M.G., Dharmaratne S.D., Diaz D., Dubey M., Duken E.E., Edessa D., Endres M., Faraon E.J.A., Farzadfar F., Fernandes E., Fischer F., Flor L.S., Ganji M., Gebre A.K., Gebremichael T.G., Geta B., Gezae K.E., Gill P.S., Gnedovskaya E.V., Gomez-Dantes H., Goulart A.C., Guo Y., Gupta R., Haj-Mirzaian A., Hamidi S., Hankey G.J., Hassen H.Y., Hay S.I., Hegazy M.I., Heidari B., Herial N.A., Hosseini M.A., Hostiuc S., Irvani S.S.N., Islam S.M.S., Jahanmehr N., Javanbakht M., Jha R.P., Jonas J.B., Jozwiak J.J., Jurisson M., Kahsay A., Kalani R., Kalkonde Y., Kamil T.A., Kanchan T., Karch A., Karimi N., Karimi-Sari H., Kasaeian A., Kassa T.D., Kazemeini H., Kefale A.T., Khader Y.S., Khalil I.A., Khan E.A., Khang Y.-H., Khubchandani J., Kim D., Kim Y.J., Kisa A., Kivimaki M., Koyanagi A., Krishnamurthi R.K., Anil Kumar G., Lafranconi A., Lewington S., Li S., Lo W.D., Lopez A.D., Lorkowski S., Lotufo P.A., Mackay M.T., Majdan M., Majdzadeh R., Majeed A., Malekzadeh R., Manafi N., Mansournia M.A., Mehndiratta M.M., Mehta V., Mengistu G., Meretoja A., Meretoja T.J., Miazgowski B., Miazgowski T., Miller T.R., Mirrakhimov E.M., Mohajer B., Mohammad Y., Mohammadoo-Khorasani M., Mohammed S., Mohebi F., Mokdad A.H., Mokhayeri Y., Moradi G., Morawska L., Moreno Velasquez I., Mousavi S.M., Muhammed O.S.S., Muruet W., Naderi M., Naghavi M., Naik G., Nascimento B.R., Negoi R.I., Nguyen C.T., Nguyen L.H., Nirayo Y.L., Norrving B., Noubiap J.J., Ofori-Asenso R., Ogbo F.A., Olagunju A.T., Olagunju T.O., Owolabi M.O., Pandian J.D., Patel S., Perico N., Piradov M.A., Polinder S., Postma M.J., Poustchi H., Prakash V., and Qorbani M.

Abstract

Background: Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016. Method(s): We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles. Finding(s): In 2016, there were 5.5 million (95% UI 5.3 to 5.7) deaths and 116.4 million (111.4 to 121.4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36.2% (-39.3 to -33.6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34.2% (-37.2 to -31.5), also with decreases in all SDI quintiles. There were 13.7 million (12.7 to 14.7) new stroke cases in 2016. Global age-standardised incidence declined by 8.1% (-10.7 to -5.5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80.1 million (74.1

Published
2019

25. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

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Abstract

Background: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. Methods: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs; the sum of years of life lost [YLLs] and years lived with disability [YLDs]) by age and sex for 15 neurological disorder categories (tetanus, meningitis, encephalitis, stroke, brain and other CNS cancers, traumatic brain injury, spinal cord injury, Alzheimer's disease and other dementias, Parkinson's disease, multiple sclerosis, motor neuron diseases, idiopathic epilepsy, migraine, tension-type headache, and a residual category for other less common neurological disorders) in 195 countries from 1990 to 2016. DisMod-MR 2.1, a Bayesian meta-regression tool, was the main method of estimation of prevalence and incidence, and the Cause of Death Ensemble model (CODEm) was used for mortality estimation. We quantified the contribution of 84 risks and combinations of risk to the disease estimates for the 15 neurological disorder categories using the GBD comparative risk assessment approach. Findings: Globally, in 2016, neurological disorders were the leading cause of DALYs (276 million [95% UI 247–308]) and second leading cause of deaths (9·0 million [8·8–9·4]). The absolute number of deaths and DALYs from all neurological disorders combined increased (deaths by 39% [34–44] and DALYs by 15% [9–21]) whereas their age-standardised rates decreased (deaths by 28% [26–30] and DALYs by 27% [24–31]) between 1990 and 2016. The only neurological disorders that had a decrease in rates and absolute numbers of deaths and DALYs were tetanus, meningitis, and encephalitis. The four largest contributors of neurological DALYs were stroke (42·2% [38·

Published
2019

26. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Johnson, CO, Minh, N, Roth, GA, Nichols, E, Alam, T, Abate, D, Abd-Allah, F, Abdelalim, A, Abraha, HN, Abu-Rmeileh, NM, Adebayo, OM, Adeoye, AM, Agarwal, G, Agrawal, S, Aichour, AN, Aichour, I, Aichour, MTE, Alahdab, F, Ali, R, Alvis-Guzman, N, Anber, NH, Anjomshoa, M, Arabloo, J, Arauz, A, Arnlov, J, Arora, A, Awasthi, A, Banach, M, Barboza, MA, Barker-Collo, SL, Barnighausen, TW, Basu, S, Belachew, AB, Belayneh, YM, Bennett, DA, Bensenor, IM, Bhattacharyya, K, Biadgo, B, Bijani, A, Bikbov, B, Bin Sayeed, MS, Butt, ZA, Cahuana-Hurtado, L, Carrero, JJ, Carvalho, F, Castaneda-Orjuela, CA, Castro, F, Catala-Lopez, F, Chaiah, Y, Chiang, PP-C, Choi, J-YJ, Christensen, H, Chu, D-T, Cortinovis, M, Moura Damasceno, AA, Dandona, L, Dandona, R, Daryani, A, Davletov, K, De Courten, B, De la Cruz-Gongora, V, Degefa, MG, Dharmaratne, SD, Diaz, D, Dubey, M, Duken, EE, Edessa, D, Endres, M, Faraon, EJA, Farzadfar, F, Fernandes, E, Fischer, F, Flor, LS, Ganji, M, Gebre, AK, Gebremichael, TG, Geta, B, Gezae, KE, Gill, PS, Gnedovskaya, EV, Gomez-Dantes, H, Goulart, AC, Grosso, G, Guo, Y, Gupta, R, Haj-Mirzaian, A, Hamidi, S, Hankey, GJ, Hassen, HY, Hay, SI, Hegazy, MI, Heidari, B, Herial, NA, Hosseini, MA, Hostiuc, S, Irvani, SSN, Islam, SMS, Jahanmehr, N, Javanbakht, M, Jha, RP, Jonas, JB, Jozwiak, JJ, Jurisson, M, Kahsay, A, Kalani, R, Kalkonde, Y, Kamil, TA, Kanchan, T, Karch, A, Karimi, N, Karimi-Sari, H, Kasaeian, A, Kassa, TD, Kazemeini, H, Kefale, AT, Khader, YS, Khalil, IA, Khan, EA, Khang, Y-H, Khubchandani, J, Kim, D, Kim, YJ, Kisa, A, Kivimaki, M, Koyanagi, A, Krishnamurthi, RK, Kumar, GA, Lafranconi, A, Lewington, S, Li, S, Lo, WD, Lopez, AD, Lorkowski, S, Lotufo, PA, Mackay, MT, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Manafi, N, Mansournia, MA, Mehndiratta, MM, Mehta, V, Mengistu, G, Meretoja, A, Meretoja, TJ, Miazgowski, B, Miazgowski, T, Miller, TR, Mirrakhimov, EM, Mohajer, B, Mohammad, Y, Mohammadoo-Khorasani, M, Mohammed, S, Mohebi, F, Mokdad, AH, Mokhayeri, Y, Moradi, G, Morawska, L, Velasquez, IM, Mousavi, SM, Muhammed, OSS, Muruet, W, Naderi, M, Naghavi, M, Naik, G, Nascimento, BR, Negoi, RI, Cuong, TN, Long, HN, Nirayo, YL, Norrving, B, Noubiap, JJ, Ofori-Asenso, R, Ogbo, FA, Olagunju, AT, Olagunju, TO, Owolabi, MO, Pandian, JD, Patel, S, Perico, N, Piradov, MA, Polinder, S, Postma, MJ, Poustchi, H, Prakash, V, Qorbani, M, Rafiei, A, Rahim, F, Rahimi, K, Rahimi-Movaghar, V, Rahman, M, Rahman, MA, Reis, C, Remuzzi, G, Renzaho, AMN, Ricci, S, Roberts, NLS, Robinson, SR, Roever, L, Roshandel, G, Sabbagh, P, Safari, H, Safari, S, Safiri, S, Sahebkar, A, Zahabi, SS, Samy, AM, Santalucia, P, Santos, IS, Santos, JV, Milicevic, MMS, Sartorius, B, Sawant, AR, Schutte, AE, Sepanlou, SG, Shafieesabet, A, Shaikh, MA, Shams-Beyranvand, M, Sheikh, A, Sheth, KN, Shibuya, K, Shigematsu, M, Shin, M-J, Shiue, I, Siabani, S, Sobaih, BH, Sposato, LA, Sutradhar, I, Sylaja, PA, Szoeke, CEI, Ao, BJT, Temsah, M-H, Temsah, O, Thrift, AG, Tonelli, M, Topor-Madry, R, Bach, XT, Khanh, BT, Truelsen, TC, Tsadik, AG, Ullah, I, Uthman, OA, Vaduganathan, M, Valdez, PR, Vasankari, TJ, Vasanthan, R, Venketasubramanian, N, Vosoughi, K, Giang, TV, Waheed, Y, Weiderpass, E, Weldegwergs, KG, Westerman, R, Wolfe, CDA, Wondafrash, DZ, Xu, G, Yadollahpour, A, Yamada, T, Yatsuya, H, Yimer, EM, Yonemoto, N, Yousefifard, M, Yu, C, Zaidi, Z, Zamani, M, Zarghi, A, Zhang, Y, Zodpey, S, Feigin, VL, Vos, T, Murray, CJL, Johnson, CO, Minh, N, Roth, GA, Nichols, E, Alam, T, Abate, D, Abd-Allah, F, Abdelalim, A, Abraha, HN, Abu-Rmeileh, NM, Adebayo, OM, Adeoye, AM, Agarwal, G, Agrawal, S, Aichour, AN, Aichour, I, Aichour, MTE, Alahdab, F, Ali, R, Alvis-Guzman, N, Anber, NH, Anjomshoa, M, Arabloo, J, Arauz, A, Arnlov, J, Arora, A, Awasthi, A, Banach, M, Barboza, MA, Barker-Collo, SL, Barnighausen, TW, Basu, S, Belachew, AB, Belayneh, YM, Bennett, DA, Bensenor, IM, Bhattacharyya, K, Biadgo, B, Bijani, A, Bikbov, B, Bin Sayeed, MS, Butt, ZA, Cahuana-Hurtado, L, Carrero, JJ, Carvalho, F, Castaneda-Orjuela, CA, Castro, F, Catala-Lopez, F, Chaiah, Y, Chiang, PP-C, Choi, J-YJ, Christensen, H, Chu, D-T, Cortinovis, M, Moura Damasceno, AA, Dandona, L, Dandona, R, Daryani, A, Davletov, K, De Courten, B, De la Cruz-Gongora, V, Degefa, MG, Dharmaratne, SD, Diaz, D, Dubey, M, Duken, EE, Edessa, D, Endres, M, Faraon, EJA, Farzadfar, F, Fernandes, E, Fischer, F, Flor, LS, Ganji, M, Gebre, AK, Gebremichael, TG, Geta, B, Gezae, KE, Gill, PS, Gnedovskaya, EV, Gomez-Dantes, H, Goulart, AC, Grosso, G, Guo, Y, Gupta, R, Haj-Mirzaian, A, Hamidi, S, Hankey, GJ, Hassen, HY, Hay, SI, Hegazy, MI, Heidari, B, Herial, NA, Hosseini, MA, Hostiuc, S, Irvani, SSN, Islam, SMS, Jahanmehr, N, Javanbakht, M, Jha, RP, Jonas, JB, Jozwiak, JJ, Jurisson, M, Kahsay, A, Kalani, R, Kalkonde, Y, Kamil, TA, Kanchan, T, Karch, A, Karimi, N, Karimi-Sari, H, Kasaeian, A, Kassa, TD, Kazemeini, H, Kefale, AT, Khader, YS, Khalil, IA, Khan, EA, Khang, Y-H, Khubchandani, J, Kim, D, Kim, YJ, Kisa, A, Kivimaki, M, Koyanagi, A, Krishnamurthi, RK, Kumar, GA, Lafranconi, A, Lewington, S, Li, S, Lo, WD, Lopez, AD, Lorkowski, S, Lotufo, PA, Mackay, MT, Majdan, M, Majdzadeh, R, Majeed, A, Malekzadeh, R, Manafi, N, Mansournia, MA, Mehndiratta, MM, Mehta, V, Mengistu, G, Meretoja, A, Meretoja, TJ, Miazgowski, B, Miazgowski, T, Miller, TR, Mirrakhimov, EM, Mohajer, B, Mohammad, Y, Mohammadoo-Khorasani, M, Mohammed, S, Mohebi, F, Mokdad, AH, Mokhayeri, Y, Moradi, G, Morawska, L, Velasquez, IM, Mousavi, SM, Muhammed, OSS, Muruet, W, Naderi, M, Naghavi, M, Naik, G, Nascimento, BR, Negoi, RI, Cuong, TN, Long, HN, Nirayo, YL, Norrving, B, Noubiap, JJ, Ofori-Asenso, R, Ogbo, FA, Olagunju, AT, Olagunju, TO, Owolabi, MO, Pandian, JD, Patel, S, Perico, N, Piradov, MA, Polinder, S, Postma, MJ, Poustchi, H, Prakash, V, Qorbani, M, Rafiei, A, Rahim, F, Rahimi, K, Rahimi-Movaghar, V, Rahman, M, Rahman, MA, Reis, C, Remuzzi, G, Renzaho, AMN, Ricci, S, Roberts, NLS, Robinson, SR, Roever, L, Roshandel, G, Sabbagh, P, Safari, H, Safari, S, Safiri, S, Sahebkar, A, Zahabi, SS, Samy, AM, Santalucia, P, Santos, IS, Santos, JV, Milicevic, MMS, Sartorius, B, Sawant, AR, Schutte, AE, Sepanlou, SG, Shafieesabet, A, Shaikh, MA, Shams-Beyranvand, M, Sheikh, A, Sheth, KN, Shibuya, K, Shigematsu, M, Shin, M-J, Shiue, I, Siabani, S, Sobaih, BH, Sposato, LA, Sutradhar, I, Sylaja, PA, Szoeke, CEI, Ao, BJT, Temsah, M-H, Temsah, O, Thrift, AG, Tonelli, M, Topor-Madry, R, Bach, XT, Khanh, BT, Truelsen, TC, Tsadik, AG, Ullah, I, Uthman, OA, Vaduganathan, M, Valdez, PR, Vasankari, TJ, Vasanthan, R, Venketasubramanian, N, Vosoughi, K, Giang, TV, Waheed, Y, Weiderpass, E, Weldegwergs, KG, Westerman, R, Wolfe, CDA, Wondafrash, DZ, Xu, G, Yadollahpour, A, Yamada, T, Yatsuya, H, Yimer, EM, Yonemoto, N, Yousefifard, M, Yu, C, Zaidi, Z, Zamani, M, Zarghi, A, Zhang, Y, Zodpey, S, Feigin, VL, Vos, T, and Murray, CJL

Abstract

BACKGROUND: Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information to health systems and policy makers on more than 300 causes of disease and injury, including stroke. The results presented here are the estimates of burden due to overall stroke and ischaemic and haemorrhagic stroke from GBD 2016. METHODS: We report estimates and corresponding uncertainty intervals (UIs), from 1990 to 2016, for incidence, prevalence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs). DALYs were generated by summing YLLs and YLDs. Cause-specific mortality was estimated using an ensemble modelling process with vital registration and verbal autopsy data as inputs. Non-fatal estimates were generated using Bayesian meta-regression incorporating data from registries, scientific literature, administrative records, and surveys. The Socio-demographic Index (SDI), a summary indicator generated using educational attainment, lagged distributed income, and total fertility rate, was used to group countries into quintiles. FINDINGS: In 2016, there were 5·5 million (95% UI 5·3 to 5·7) deaths and 116·4 million (111·4 to 121·4) DALYs due to stroke. The global age-standardised mortality rate decreased by 36·2% (-39·3 to -33·6) from 1990 to 2016, with decreases in all SDI quintiles. Over the same period, the global age-standardised DALY rate declined by 34·2% (-37·2 to -31·5), also with decreases in all SDI quintiles. There were 13·7 million (12·7 to 14·7) new stroke cases in 2016. Global age-standardised incidence declined by 8·1% (-10·7 to -5·5) from 1990 to 2016 and decreased in all SDI quintiles except the middle SDI group. There were 80·1 million (74·1 to

Published
2019

30. Do Commonly Used Functional Outcome Measures Capture Activities that Are Relevant for People with Stroke in India?

Author

Prakash, V., Ganesan, Mohan, Vasanthan, R., and Hariohm, K.

Subjects
STROKE patients, MEDICAL rehabilitation, BODY movement
Abstract

Objectives: In India, post-stroke outcomes are determined using functional outcome measures (FOMs), the contents of which have not been validated for their relevance to the Indian population. In this study, we aimed to evaluate the cultural validity of five frequently used stroke-specific FOMs by comparing their contents with the problems reported by patients with stroke in India. Methods: Face-to-face structured interviews were conducted with 152 patients diagnosed with stroke in India. Problems and goals identified by the patients were compared to each item included in the FOMs used in stroke rehabilitation. Results: The Stroke Impact Scale (SIS) and the Frenchay Activities Index (FAI) include items related to the most frequently identified problems. However, neither covers problems related to the need for squatting and sitting on the floor. Use of public transport and community walking are not included in the SIS. Leisure and recreational activities (e.g. gardening, reading books), cognitive and speech functions (e.g. memory, thinking) and bowel and bladder dysfunctions were the common items identified as “not a problem” or “not relevant” by the patients. Discussion: Our findings suggest that the SIS and FAI are the most appropriate FOMs for patients with stroke in India as they include items related to the majority of problems identified by study participants. Many items on both measures, however, were identified as not a problem or not relevant. There is a need for developing culture-specific FOMs that incorporate all major concerns expressed by patients with stroke in India. [ABSTRACT FROM PUBLISHER]

Published
2017
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31. Evolution of Physical-Layer Communications Research in the Post-5G Era

Author

Vasanthan Raghavan and Junyi Li

Subjects
5G, 5G new radio (5G-NR), 5G-evolution, post-5G, 6G, communications theory, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

The evolving fifth generation new radio cellular standardization efforts at the third generation partnership project brings into focus a number of questions on relevant research problems in physical-layer communications for study by both academia and industry. To address this question, we show that the peak download data rates for both WiFi and cellular systems have been scaling exponentially with time over the last 25 years. While keeping up with the historic cellular trends will be possible in the near-term with a modest bandwidth and hardware complexity expansion, even a reasonable stretching of this road-map into the far future would require significant bandwidth accretion, perhaps possible at the millimeter wave, sub-millimeter wave, or terahertz regimes. The consequent increase in focus on systems at higher carrier frequencies necessitates a paradigm shift from the reuse of over-simplified (yet mathematically elegant) models, often inherited from sub-6 GHz systems to a more holistic view, where real measurements guide, motivate, and refine the building of relevant but possibly complicated models, solution space(s), and good solutions. To motivate the need for this shift, we illustrate how the traditional abstraction fails to correctly estimate the delay spread of millimeter wave wireless channels and hand blockage losses at higher carrier frequencies. We conclude this paper with a broad set of implications for future research prospects at the physical-layer, including key use-cases, possible research policy initiatives, and structural changes needed in telecommunications departments at universities.

Published
2019
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32. Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy

Author

Vasanthan Ravichandran, Minjong Lee, Thuy Giang Nguyen Cao, and Min Suk Shim

Subjects
polysorbate, surfactants, blood–brain barrier, cancer therapy, drug delivery, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives. Recently, various PS-based formulations have been developed for safe and efficient drug delivery. This review introduces the general features of PSs and PS-based drug carriers, summarizes recent progress in the development of PS-based drug formulations, and discusses the physicochemical properties, biological safety, P-glycoprotein inhibitory properties, and therapeutic applications of PS-based drug formulations. Additionally, recent advances in brain-targeted drug delivery using PS-based drug formulations have been highlighted. This review will help researchers understand the potential of PSs as effective drug formulation agents.

Published
2021
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34. Effectiveness of a multifactorial context-enhancing functional therapy to promote functional arm use and recovery of stroke survivors: study protocol for a clinical trial

Author

Sankar Prasad Gorthi, Vasanthan Rajagopalan, Manikandan Natarajan, Sebastian Padickaparambil, and John M Solomon

Subjects
Medicine
Abstract

Introduction After a stroke, 55% of survivors do not regain the ability to completely use their arm in daily life functioning. Currently, evidence-based guidelines recommend functional training for improving the affected hand after stroke. However, promoting an optimal quantity and quality of functional training is influenced by personal and environmental contextual factors. Studies that comprehensively target multiple factors regulating arm use are limited. This study compares the effects of functional training to multifactorial context-enhancing functional training program for improving functional arm use and recovery after stroke.Methods and analysis This is a protocol for an observer-blinded, two parallel groups, randomised controlled trial. A total of 126 community-dwelling subacute and chronic stroke survivors will be included in the study. A tailor-made multifactorial context-enhancing intervention-incorporating education, environmental enrichment and behaviour change techniques to reinforce functional training will be provided to the experimental group. The functional training group will be provided with functional exercises. The intervention will be delivered for 2 months. The primary outcomes of functional arm use and recovery will be measured using Motor Activity Log, Goal Attainment Scale and Rating of Everyday Arm-use in the Community and Home scale. The secondary outcomes of arm motor impairment and function will be measured using Fugl-Meyer upper limb score, Action Research Arm Test, ABILHAND questionnaire and Stroke Impact Scale. These will be measured at three points in time: before, after 2 months and after 1-month follow-up. The outcome measures will be analysed using one-way analysis of variance and regression analysis will be performed to identify factors limiting optimal task practice.Ethics and dissemination The study has been approved by the Institutional Ethics Committee of Kasturba Hospital, Manipal, India. Participants will sign a written informed consent prior to participation. The results will be published on completion of the trial and communicated to community-dwelling stroke survivors.Trial registration number CTRI/2017/10/010108

Published
2019
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35. The Burden of Recurrent Head and Neck Squamous Cell Carcinoma Across the United Kingdom: Results From a National Snapshot Study.

Author

Williamson A, Lim AE, Green F, Lee YK, Li L, Moen C, Vasanthan R, Wharf O, Wong J, and Paleri V

Abstract

Background: To investigate the management of recurrent head and neck squamous cell carcinoma (rHNSCC) and describe survival outcomes., Methods: Post hoc subgroup analysis of a retrospective national observational cohort was conducted. All patients with rHNSCC who received a definitive treatment decision between September 1, 2021 and November 30, 2021 were included. Survival analysis was stratified according to subsite, primary versus recurrent disease, and surgical versus nonsurgical treatment., Results: Data from 202 rHNSCC patients were derived from a cohort of 1488 patients submitted by 50 UK centers. Median age was 66 years (IQR 58-74), and 142 (70.3%) were male. The most common recurrence subsites were oropharynx (20.5%), oral cavity (19.5%), larynx (16.4%), and hypopharynx (14.9%). Ninety-three (48.4%) were managed curatively. Surgery was the most common treatment for laryngeal (59.4%), oral cavity (60.5%), hypopharyngeal (44.8%), and oropharyngeal (37.5%) cancers. Two-year overall (OS), disease-free (DFS), disease-specific (DSS), and local recurrence free survival (LRFS) were 41.1%, 39.1%, 42.2%, and 39.3%, respectively. rHNSCC treated with surgery had improved OS (p = 0.0005), DFS (p = 0.012), DSS (p = 0.0003), and LRFS (p = 0.007), over nonsurgical treatments. Compared to primary cancers, rHNSCC presents with more advanced T stage (p < 0.001) and distant metastasis (p < 0.001), receives less curative treatment (p < 0.001), and has worse survival outcomes (all p < 0.001). On multivariate analysis, salvage surgery, radiotherapy, and p16 status were independent prognostic factors of all survival outcomes., Conclusions: Recurrent HNSCC is associated with high rates of incurable disease and worse survival than primary cancers. Surgery remains the most common curative treatment in rHNSCC, however future studies are necessary to improve patient selection and optimize outcomes following salvage treatment., (© 2024 Wiley Periodicals LLC.)

Published
2024
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38. Primary Hyperparathyroidism: Outcomes of Repeated Imaging After Initial Negative Radiological Localization.

Author

Karunaratne D, Karunaratne N, Vasanthan R, Ojofeitimi O, Owens E, Sathiskumar P, Till D, Kirkland P, and Howlett D

Abstract

Background: Radiological localization imaging aids in the identification of abnormal parathyroid glands resulting in primary hyperparathyroidism (PHPT), thereby facilitating minimally invasive parathyroid surgery. Sometimes initial imaging may fail to identify the abnormal gland and imaging may therefore be repeated. This study explored patient outcomes of repeated parathyroid localization imaging, after initial negative gland localization, at a United Kingdom institution., Methodology: Data was retrospectively collected and analyzed for patients with PHPT undergoing repeated imaging during a five-year period (2015-2020). The total number of episodes of scanning, types of scans performed, the time interval between scans and the imaging success of gland localization were recorded. We explored the reasons for repeated imaging and attempted to identify any factors that might predict subsequent positive radiological localization., Results: A total of 45 patients were identified who underwent repeated localizing imaging after first localizing imaging was negative. Of these, 39 did not undergo surgery despite repeat imaging being undertaken; 11 out of these 39 patients (28%) had subsequent positive localization scans. Again, a large proportion of patients were managed conservatively, despite the repeated sets of imaging being done. Patients undergoing three or four sets of repetitive imaging did not have imaging or surgical success., Conclusion: A streamlined parathyroid pathway should be followed whereby patients should be triaged for suitability for surgery prior to repeated imaging. A second set of scans should be offered when patients are unsuitable for conservative management and are willing and fit to undergo surgery. There is no merit to repeating imaging more than twice., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2023, Karunaratne et al.)

Published
2023
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39. Dermatoscopic finding of white circles in an invasive pigmented melanoma.

Author

Vasanthan R, Akay BN, Clark SP, and Rosendahl C

Subjects
Male, Humans, Aged, Dermoscopy, Australia, Melanoma, Cutaneous Malignant, Skin Neoplasms pathology, Melanoma diagnostic imaging, Melanoma pathology
Abstract

Dermatoscopic white circles, seen with both non-polarized and polarized dermatoscopy, are a known clue to actinic keratosis in a flat lesion and invasive squamous cell carcinoma in a raised lesion. We have not discovered a previous published example of this clue in a melanoma. We present a case report of a 70-year-old Australian male with a pigmented superficial spreading melanoma on the face, Breslow thickness 1 mm, with dermatoscopic white circles displayed with both polarized and non-polarized dermatoscopy, and with dermatopathological correlation., (© 2023 Australasian College of Dermatologists.)

Published
2023
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40. Dual-modality emergency management of a rare cause of an aorto-oesophageal fistula: a case report.

Author

Vasanthan R, Tabbakh Y, Doran S, Baker D, Hague J, Qureshi Y, Dawas K, and Mohammadi B

Abstract

Aorto-oesophageal fistula (AOF) is a life-threatening condition that usually presents with upper gastro-intestinal haemorrhage. This case report details the emergency presentation and management of a 51-year-old male who presented with hematemesis secondary to an impacted denture (ingested two years previously) in the oesophagus that had led to an AOF. This necessitated urgent thoracic endovascular aortic repair followed by thoracotomy, oesophagotomy, T-tube insertion and oesophagostomy. This is the first documentation in the literature of the dual-modality management for this rare cause of AOF and demonstrates the multidisciplinary approach to successful management of this complex yet rare presentation., (Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2021.)

Published
2021
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41. Laryngotracheal stenosis following intubation and tracheostomy for COVID-19 pneumonia: a case report.

Author

Vasanthan R, Sorooshian P, Sri Shanmuganathan V, and Al-Hashim M

Abstract

Laryngotracheal stenosis (LTS) is a rare but serious condition characterized by narrowing of the airway. Iatrogenic injury from endotracheal intubation or tracheostomy insertion is the most common cause of LTS. We present the first reported experience of managing a patient diagnosed with subglottic stenosis (a subtype of LTS) following previous intubation and tracheostomy for coronavirus disease 2019 (COVID-19). This patient required an urgent surgical tracheostomy and subsequent referral to a tertiary airway surgery unit for definitive treatment, which included microlaryngoscopy, laser excision and balloon dilatation. This case highlights that LTS should be included in the differential diagnosis for patients re-presenting with breathing difficulties after prolonged intubation or tracheostomy for COVID-19. Furthermore, it raises the concern of a rise in the incidence of this condition and an increased burden on the few units specializing in airway surgery., (Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2021.)

Published
2021
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