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1. Risk factors for cerebral palsy and movement difficulties in 5-year-old children born extremely preterm

Author: MS Neonatologie, Aubert, Adrien M., Costa, Raquel, Johnson, Samantha, Aden, U., Cuttini, M., Koopman-Esseboom, C., Lebeer, Jo, Varendi, H., Zemlin, Michael, Pierrat, V., Zeitlin, Jennifer, the SHIPS Research group, MS Neonatologie, Aubert, Adrien M., Costa, Raquel, Johnson, Samantha, Aden, U., Cuttini, M., Koopman-Esseboom, C., Lebeer, Jo, Varendi, H., Zemlin, Michael, Pierrat, V., Zeitlin, Jennifer, and the SHIPS Research group
Published: 2023

2. Risk assessment of neonatal excipient exposure: Lessons from food safety and other areas

Author: Turner, M.A., Duncan, J.C., Shah, U., Metsvaht, T., Varendi, H., Nellis, G., Lutsar, I., Yakkundi, S., McElnay, J.C., Pandya, H., Mulla, H., Vaconsin, P., Storme, T., Rieutord, A., and Nunn, A.J.
Published: 2014
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3. Health-related quality of life of children born very preterm : a multinational European cohort study

Author: Kim, Sung Wook, Andronis, Lazaros, Seppänen, Anna-Veera, Aubert, Adrien M., Barros, Henrique, Draper, Elizabeth S., Sentenac, Mariane, Zeitlin, Jennifer, Petrou, Stavros, Lebeer, Jo, Van Reempts, Patrick, Bruneel, E., Cloet, E., Oostra, A., Ortibus, E., Sarrechia, Iemke, Boerch, K., Pedersen, P., Toome, L., Varendi, H., Männamaa, M., Ancel, P.Y., Burguet, A., Jarreau, P.H., Pierrat, V., Truffert, P., Maier, R.F., Zemlin, M., Misselwitz, B., Wohlers, L., Cuttini, M., Croci, I., Carnielli, V., Ancora, G., Faldella, G., Ferrari, F., van Heijst, A., Koopman-Esseboom, C., Gadzinowski, J., Mazela, J., Montgomery, A., Pikuła, T., Barros, H., Costa, R., Rodrigues, C., Aden, U., Draper, E.S., Fenton, A., Johnson, S.J., Mader, S., Thiele, N., Pfeil, J.M., Petrou, S., Kim, S.W., Andronis, L., Zeitlin, J., Aubert, A.M., Bonnet, C., El Rafei, R., Seppänen, A.V., and SHIPS Research Group
Subjects: RJ, Public Health, Environmental and Occupational Health, Human medicine, RG
Abstract: Purpose This study aims to (1) describe the health-related quality of life (HRQoL) outcomes experienced by children born very preterm (28–31 weeks’ gestation) and extremely preterm ( Methods This investigation was based on data for 3687 children born at ™ GCS scores. A mediation analysis that applied generalised structural equation modelling explored the association between potential mediators and PedsQL™ GCS scores. Results The multi-level OLS regression (fully adjusted model) revealed that birth at ™ GCS score of 0.35, 3.71 and 5.87, respectively. The mediation analysis revealed that the indirect effects of BPD and severe non-respiratory morbidity on the total PedsQL™ GCS score translated into decrements of 1.73 and 17.56, respectively, at Conclusion The findings suggest that HRQoL is particularly impaired by extremely preterm birth and the concomitant complications of preterm birth such as BPD and severe non-respiratory morbidity.
Published: 2022

4. Variation in term birthweight across European countries affects the prevalence of small for gestational age among very preterm infants

Author: Zeitlin, Jennifer, Bonamy, Anna‐Karin Edstedt, Piedvache, Aurelie, Cuttini, Marina, Barros, Henrique, Van Reempts, Patrick, Mazela, Jan, Jarreau, Pierre‐Henri, Gortner, Ludwig, Draper, Elizabeth S., Maier, Rolf F., Martens, E, Martens, G, Boerch, K, Hasselager, A, Huusom, L, Pryds, O, Weber, T, Toome, L, Varendi, H, Ancel, PY, Blondel, B, Burguet, A, Truffert, P, Misselwitz, B, Schmidt, S, Baronciani, D, Gargano, G, Agostino, R, DiLallo, D, Franco, F, Carnielli, V, Koopman‐Esseboom, C, Van Heijst, A, Nijman, J, Gadzinowski, J, Graça, LM, Machado, MC, Carrapato, MRG, Rodrigues, T, Norman, M, Wilson, E, Boyle, E, Manktelow, BN, Fenton, AC, Milligan, DWA, and Bonet, M
Published: 2017
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5. Variability in the management and outcomes of extremely preterm births across five European countries: a population-based cohort study

Author: Smith, Lucy K, Blondel, Beatrice, Van Reempts, Patrick, Draper, Elizabeth S, Manktelow, Bradley N, Barros, Henrique, Cuttini, Marina, Zeitlin, Jennifer, Martens, E, Martens, G, Van Reempts, P, Boerch, K, Hasselager, A, Huusom, L, Pryds, O, Weber, T, Toome, L, Varendi, H, Ancel, PY, Blondel, B, Burguet, A, Jarreau, PH, Truffert, P, Maier, RF, Misselwitz, B, Schmidt, S, Gortner, L, Baronciani, D, Gargano, G, Agostino, R, DiLallo, D, Franco, F, Carnielli, V, Cuttini, M, Koopman-Esseboom, C, van Heijst, A, Nijman, J, Gadzinowski, J, Mazela, J, Graça, LM, Machado, MC, Rodrigues, Carina, Rodrigues, T, Bonamy, AK, Norman, M, Wilson, E, Boyle, E, Draper, ES, Manktelow, BN, Fenton, AC, Milligan, DWA, Zeitlin, J, Bonet, M, and Piedvache, A
Published: 2017
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6. An Observational Study of Blood Concentrations and Kinetics of Methyl- and Propyl-Parabens in Neonates

Author: Mulla, H., Yakkundi, S., McElnay, J., Lutsar, I., Metsvaht, T., Varendi, H., Nellis, G., Nunn, A., Duncan, J., Pandya, H., and Turner, M.
Published: 2015
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7. Wide variation in severe neonatal morbidity among very preterm infants in European regions

Author: Bonamy, A, Zeitlin, J, Piedvache, A, Maier, R, Van Heijst, A, Varendi, H, Manktelow, B, Fenton, A, Mazela, J, Cuttini, M, Norman, M, Petrou, S, Van Reempts, P, Barros, H, and Draper, E
Subjects: macromolecular substances, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract: Objective: To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates.Design: Area-based cohort study of all births before 32 weeks of gestational age.Setting: 16 regions in 11 European countries in 2011/2012.Patients: Survivors to discharge from neonatal care (n=6422).Main outcome measures: Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades >= 3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics.Results: 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P< 0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P= 0.50).Conclusion: Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.
Published: 2019

8. Cohort profile : effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort

Author: Zeitlin, J, Maier, RF, Cuttini, M, Aden, U, Boerch, K, Gadzinowski, J, Jarreau, P-H, Lebeer, J, Norman, M, Pedersen, P, Petrou, S, Pfeil, JM, Toome, L, van Heijst, A, van Reempts, P, Varendi, H, Barros, H, Groups, EPICE and SHIPS Research, Sarrechia, Iemke, EPICE Reseach Group, SHIPS Research Group, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), DHU Risques Et Grossesse, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Philipps Universität Marburg = Philipps University of Marburg, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Department of Women's and Children's Health [Stockholm, Sweden], Karolinska University Hospital [Stockholm], Copenhagen University Hospital Hvidovre [Hvidovre, Danemark], University of Copenhagen = Københavns Universitet (UCPH), Poznan University of Medical Sciences [Poland] (PUMS), Department of Primary & Interdisciplinary Care, Disability Studies [Antwerpen, Belgium] (Faculty of Medicine), University of Antwerp (UA), Department of Clinical Science, Intervention and Technology [Stockholm, Sweden], Karolinska Institutet [Stockholm], Aalborg University [Denmark] (AAU), Warwick Medical School, University of Warwick [Coventry], Nuffield Department of Primary Care Health Sciences, University of Oxford, University of Oxford, European Foundation for the Care of Newborn Infants [Munich, Germany] (EFCNI), Tallinn Children's Hospital [Tallinn, Estonia], University of Tartu, Radboud University Medical Center [Nijmegen], Antwerp University Hospital [Edegem] (UZA), Study Centre for Perinatal Epidemiology [Brussels, Belgium] (SCPE), Tartu University Hospital [Tartu, Estonia], Instituto de Saúde Pública da Universidade do Porto [Porto, Portugal] (ISPUP), Universidade do Porto = University of Porto, University of Leicester, EPICE and SHIPS Research Group: J Lebeer, P Van Reempts, E Bruneel, E Cloet, A Oostra, E Ortibus, I Sarrechia, K Boerch, L Huusom, P Pedersen, T Weber, L Toome, H Varendi, M Männamaa, P Y Ancel, A Burguet, P H Jarreau, V Pierrat, P Truffert, R F Maier, M Zemlin, B Misselwitz, S Schmidt, L Wohlers, M Cuttini, D Di Lallo, G Ancora, D Baronciani, V Carnielli, I Croci, G Faldella, F Ferrari, F Franco, G Gargano, A van Heijst, C Koopman-Esseboom, J Gadzinowski, J Mazela, A Montgomery, T Pikuła, H Barros, R Costa, L Mendes Graça, M do Céu Machado, C Rodrigues, T Rodrigues, U Aden, A K Edstedt Bonamy, M Norman, E S Draper, E M Boyle, A Fenton, S J Johnson, B N Manktelow, D W A Milligan, S Mader, N Thiele, J M Walz, S Petrou, J Zeitlin, M Bonet, C Bonnet, R El Raffei, A Piedvache, A V Seppanen, PHILIBERT, Marianne, Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Philipps University of Marburg, University of Copenhagen = Københavns Universitet (KU), University of Oxford [Oxford], and Universidade do Porto
Subjects: Critical Care, [SDV]Life Sciences [q-bio], Infant, Newborn, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Cohort Studies, Europe, [SDV] Life Sciences [q-bio], Perinatal Care, Treatment Outcome, Pregnancy, Infant, Extremely Premature, Humans, Premature Birth, Female, Human medicine, Cohort Profiles, ComputingMilieux_MISCELLANEOUS
Abstract: Contains fulltext : 220753.pdf (Publisher’s version ) (Open Access)
Published: 2020

9. Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort

Author: Zeitlin, J., Maier, R.F., Cuttini, M., Aden, U., Boerch, K., Gadzinowski, J., Jarreau, P.H., Lebeer, J., Norman, M., Pedersen, P., Petrou, S., Pfeil, J.M., Toome, L., Heijst, A.F. van, Reempts, P. Van, Varendi, H., Barros, H., Draper, E.S., Zeitlin, J., Maier, R.F., Cuttini, M., Aden, U., Boerch, K., Gadzinowski, J., Jarreau, P.H., Lebeer, J., Norman, M., Pedersen, P., Petrou, S., Pfeil, J.M., Toome, L., Heijst, A.F. van, Reempts, P. Van, Varendi, H., Barros, H., and Draper, E.S.
Abstract: Contains fulltext : 220753.pdf (Publisher’s version ) (Open Access)
Published: 2020

10. Cohort study from 11 European countries highlighted differences in the use and efficacy of hypothermia prevention strategies after very preterm birth

Author: Wilson, Emilija, Zeitlin, Jennifer, Piedvache, Aurélie, Misselwitz, Bjoern, Christensson, Kyllike, Maier, Rolf F., Norman, Mikael, Edstedt Bonamy, Anna Karin, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W.A., Bonet, M., Instituto de Saúde Pública, and Intituto de Saúde Pública
Subjects: Male, Hyperthermia, Pediatrics, medicine.medical_specialty, Delivery rooms, Hypothermia prevention, Hypothermia, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Intensive care, medicine, Humans, Very Preterm Birth, Pediatrics, Perinatology, and Child Health, 030212 general & internal medicine, business.industry, European study, Infant, Newborn, Gestational age, General Medicine, medicine.disease, Perinatology, 3. Good health, and Child Health, Europe, Perinatal Care, Pediatrics, Perinatology and Child Health, Hypothermia - Prevention, Gestation, Female, Neonatal intensive care, medicine.symptom, business, Infant, Premature, Very preterm birth, Cohort study
Abstract: Aim: This study investigated the different strategies used in 11 European countries to prevent hypothermia, which continues to affect a large proportion of preterm births in the region. Methods: We examined the association between the reported use of hypothermia prevention strategies in delivery rooms and body temperatures on admission to neonatal intensive care units (NICUs) in 5861 infants born at 22 + 0 to 31 +6 weeks of gestation. The use of plastic bags, wraps, caps, exothermic heat and mattresses was investigated. Results: The proportion of infants born in units that systematically used one or more hypothermia prevention strategies was 88.2% and 50.9% of those infants were hypothermic on admission to NICUs. Of the 9.6% born in units without systematic hypothermia prevention, 73.2% were hypothermic. Only 2.2% of infants were born in units with no reported prevention strategies. Lower gestational age increased the probability of hypothermia. No significant differences were found between the various hypothermia prevention strategies. Hyperthermia was seen in 4.8% of all admitted infants. Conclusion: Very preterm infants had lower risks of hypothermia on NICU admission if the unit used systematic prevention strategies. All the strategies had similar effects, possibly due to implementation rather than a strategy's specific efficacy.
Published: 2018

11. European Study of Neonatal Exposure to Excipients: An update

Author: Turner, M. A., Duncan, J., Shah, U., Metsvaht, T., Varendi, H., Nellis, G., Lutsar, I., Vaconsin, P., Storme, T., Rieutord, A., and Nunn, A. J.
Published: 2013
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12. Wide variation in severe neonatal morbidity among very preterm infants in european regions

Author: Edstedt Bonamy, A-K. (Anna-Karin), Zeitlin, J. (Jennifer), Piedvache, A. (Aurelie), Maier, R.F. (Rolf F.), Van Heijst, A. (Arno), Varendi, H. (Heili), Manktelow, B.N. (Bradley N.), Fenton, A. (Alan), Mazela, J. (Jan), Cuttini, M. (Marina), Norman, M. (Mikael), Petrou, S. (Stavros), Van Reempts, P. (Patrick), Barros, H. (Henrique), Draper, E.S. (Elizabeth S.), Martens, E. (E.), Martens, G. (G.), Boerch, K. (K.), Hasselager, A. (A.), Huusom, L. (L.), Pryds, O. (O.), Weber, T. (Tom), Toome, L. (Liis), Ancel, P-Y. (Pierre-Yves), Blondel, B. (Béatrice), Burguet, A. (Antoine), Jarreau, P-H. (Pierre-Henri), Truffert, P. (Patrick), Schmidt, S. (S.), Gortner, L. (Ludwig), Baronciani, D. (D.), Gargano, G. (G.), Agostino, R. (R.), Dilallo, D. (D.), Franco, F. (F.), Carnielli, V. (V.), Koopman-Esseboom, C. (C.), Nijman, J. (J.), Gadzinowski, J. (Janusz), Graca, L.M. (L. M.), Machado, M.C. (M. C.), Rodrigues, C. (Carina), Rodrigues, T. (T.), Wilson, E. (Emilija), Boyle, E.M. (Eileen Mary), Milligan, D.W.A. (D. W. A.), Bonet, M. (Mercedes), CHU Lille, Université de Lille, Karolinska Institutet [Stockholm], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)], Radboud University Medical Center [Nijmegen], University of Tartu, University of Leicester, Newcastle University [Newcastle], IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Poznan University of Medical Sciences [Poland] [PUMS], University of Warwick [Coventry], University of Antwerp [UA], Hvidovre Hospital, Université Paris Descartes - Paris 5 [UPD5], CHU Dijon, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Saarland University [Saarbrücken], Istituto Nazionale di Riposo e Cura per Anziani di Ancona, University Medical Center [Utrecht], Université de Lisbonne, Hospital de São João [Porto], Karolinska University Hospital [Stockholm], and Royal Victoria Hospital
Abstract: OBJECTIVE: To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. METHODS: Area-based cohort study of all births before 32 weeks of gestational age. METHODS: 16 regions in 11 European countries in 2011/2012. METHODS: Survivors to discharge from neonatal care (n=6422). METHODS: Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. RESULTS: 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%-23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P
Published: 2019

13. Preliminary evidence of a sensitive period for olfactory learning by human newborns

Author: Romantshik, O, Porter, R H, Tillmann, V, and Varendi, H
Published: 2007

14. Low breastfeeding continuation to 6 months for very preterm infants: A European multiregional cohort study

Author: MS Neonatologie, Arts-assistenten Kinderen, Bonnet, Camille, Blondel, Béatrice, Piedvache, Aurélie, Wilson, Emilija, Bonamy, Anna Karin Edstedt, Gortner, L., Rodrigues, Carina, van Heijst, Arno, Draper, Elizabeth S., Cuttini, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., the EPICE Research Group, MS Neonatologie, Arts-assistenten Kinderen, Bonnet, Camille, Blondel, Béatrice, Piedvache, Aurélie, Wilson, Emilija, Bonamy, Anna Karin Edstedt, Gortner, L., Rodrigues, Carina, van Heijst, Arno, Draper, Elizabeth S., Cuttini, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., and the EPICE Research Group
Published: 2019

15. Wide variation in severe neonatal morbidity among very preterm infants in European regions

Author: Bonamy, A.K. Edstedt, Zeitlin, J., Piedvache, A., Maier, R.F., Heijst, A. van, Varendi, H., Manktelow, B.N., Fenton, A., Mazela, J., Cuttini, M., Norman, M., Petrou, S., Reempts, P.V., Barros, H., Draper, E.S., Bonamy, A.K. Edstedt, Zeitlin, J., Piedvache, A., Maier, R.F., Heijst, A. van, Varendi, H., Manktelow, B.N., Fenton, A., Mazela, J., Cuttini, M., Norman, M., Petrou, S., Reempts, P.V., Barros, H., and Draper, E.S.
Abstract: Contains fulltext : 202712.pdf (publisher's version ) (Open Access), OBJECTIVE: To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. DESIGN: Area-based cohort study of all births before 32 weeks of gestational age. SETTING: 16 regions in 11 European countries in 2011/2012. PATIENTS: Survivors to discharge from neonatal care (n=6422). MAIN OUTCOME MEASURES: Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades >/=3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. RESULTS: 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%-23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P<0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P=0.50). CONCLUSION: Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates.
Published: 2019

16. Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age.

Author: Piedvache, Aurélie, van Buuren, Stef, Barros, Henrique, Ribeiro, Ana Isabel, Draper, Elizabeth, Zeitlin, Jennifer, the EPICE Research group, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L. D., Pryds, O., Weber, T., Toome, L., Varendi, H., France, Ile-de, Ancel, P. Y., and Blondel, B.
Subjects: PREGNANCY complications, GESTATIONAL age, NEURAL development, CONFIDENCE intervals, AGE
Abstract: Background: Loss to follow-up is a major challenge for very preterm (VPT) cohorts; attrition is associated with social disadvantage and parents with impaired children may participate less in research. We investigated the impact of loss to follow-up on the estimated prevalence of neurodevelopmental impairment in a VPT cohort using different methodological approaches.Methods: This study includes births < 32 weeks of gestational age (GA) from 4 regions in the UK and Portugal participating in a European birth cohort (N = 1737 survivors). Data on maternal characteristics, pregnancy complications, neonatal outcomes and neighborhood deprivation were collected at baseline. Neurodevelopment was assessed at 2 years of corrected age (CA) using standardized parent-report measures. We applied (1) multiple imputation (MI) and (2) inverse probability weighting (IPW) to estimate the impact of non-response on the prevalence of moderate to severe neurodevelopmental impairment and assessed violations of the missing at random (MAR) assumption using the delta method.Results: 54.2% of children were followed-up. Follow-up was less likely when mothers were younger, multiparous, foreign-born, did not breastfeed and came from deprived areas. The prevalence of neurodevelopmental impairment was 18.4% (95% confidence interval (CI):15.9-21.1) and increased to 20.4% (95%CI: 17.3-23.4) and 20.0% (95%CI:16.9-23.1) for MI and IPW models, respectively. Simulating strong violations of MAR (children with impairments being 50% less likely to be followed-up) raised estimates to 23.6 (95%CI:20.1-27.1) CONCLUSIONS: In a VPT cohort with high loss to follow-up, correcting for attrition yielded modest increased estimates of neurodevelopmental impairment at 2 years CA; estimates were relatively robust to violations of the MAR assumption. [ABSTRACT FROM AUTHOR]
Published: 2021
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17. Wide variation in severe neonatal morbidity among very preterm infants in European regions

Author: Bonamy, AK, Zeitlin, J, Piedvache, A, Maier, RF, van Heijst, A, Varendi H, Manktelow BN, Fenton A, Mazela J, Cuttini M, Norman M, Petrou S, Reempts PV, Barros H, Rodrigues, C, Rodrigues T, Instituto de Saúde Pública, and Intituto de Saúde Pública
Subjects: Very preterm infants, RJ101, Neonatal morbidity, macromolecular substances, RG, health care economics and organizations
Abstract: Objective To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. Design Area-based cohort study of all births before 32 weeks of gestational age. Setting 16 regions in 11 European countries in 2011/2012. Patients Survivors to discharge from neonatal care (n=6422). Main outcome measures Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. Results 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%–23.5%) and 13.8% including severe BPD (regional range 10.0%–23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%–18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P
Published: 2018

18. Cohort study from 11 European countries highlighted differences in the use and efficacy of hypothermia prevention strategies after very preterm birth

Author: MS Neonatologie, Intensive care patientenzorg, Wilson, Emilija, Zeitlin, Jennifer, Piedvache, Aurélie, Misselwitz, Bjoern, Christensson, Kyllike, Maier, Rolf F., Norman, Mikael, Edstedt Bonamy, Anna Karin, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W.A., Bonet, M., the EPICE Research Group, MS Neonatologie, Intensive care patientenzorg, Wilson, Emilija, Zeitlin, Jennifer, Piedvache, Aurélie, Misselwitz, Bjoern, Christensson, Kyllike, Maier, Rolf F., Norman, Mikael, Edstedt Bonamy, Anna Karin, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W.A., Bonet, M., and the EPICE Research Group
Published: 2018

19. Does the newborn baby find the nipple by smell?

Author: Varendi, H, Porter, R H, and Winberg, J.
Published: 1994

20. Evidence-based neonatal unit practices and determinants of postnatal corticosteroid-use in preterm births below 30 weeks ga in europe. A population-based cohort study

Author: Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., Piedvache, A., CHU Lille, Université de Lille, Santé publique : épidémiologie et qualité des soins - EA 2694, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Université Paris Descartes - Paris 5 [UPD5], Poznan University of Medical Sciences [Poland] [PUMS], Newcastle University [Newcastle], Saarland University [Saarbrücken], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)], Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique [CRESS - U1153], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Paris Descartes - Paris 5 (UPD5), Maternité Port-Royal [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Poznan University of Medical Sciences [Poland] (PUMS), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Lille, LillOA
Subjects: Pediatrics, Hydrocortisone, NSAIDs, [SDV]Life Sciences [q-bio], Surfactants, lcsh:Medicine, Neonatal Care, Biochemistry, Geographical Locations, Families, 0302 clinical medicine, MESH: Newborn, MESH: Gestational Age, Medicine and Health Sciences, Data Protection Act 1998, Confidentiality, 030212 general & internal medicine, Lipid Hormones, lcsh:Science, MESH: Cohort Studies, Children, Medicine(all), Analgesics, Multidisciplinary, Agricultural and Biological Sciences(all), Organic Compounds, Drugs, MESH: Infant, 3. Good health, [SDV] Life Sciences [q-bio], Europe, Chemistry, Physical Sciences, Steroids, Infants, Cohort study, Research Article, medicine.medical_specialty, Evidence-based practice, Materials Science, MEDLINE, MESH: Adrenal Cortex Hormones/administration & dosage, Unit (housing), 03 medical and health sciences, 030225 pediatrics, medicine, Journal Article, MESH: Neonatal, Neonatal care, MESH: Premature, Materials by Attribute, Pharmacology, Steroid Hormones, MESH: Humans, business.industry, Biochemistry, Genetics and Molecular Biology(all), lcsh:R, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, Neonates, Pain management, Hormones, Data sharing, Health Care, Data access, Age Groups, Family medicine, People and Places, lcsh:Q, MESH: Intensive Care Units, Population Groupings, MESH: Europe, Neonatology, business, Genetics and Molecular Biology(all), Developmental Biology
Abstract: Correction Published: February 13, 2017 https://doi.org/10.1371/journal.pone.0172408The following information is missing from the Funding section: Funding for this open access publication was provided by the FP7 Post-Grant Open Access Pilot.; BACKGROUND: Postnatal corticosteroids (PNC) were widely used to treat and prevent bronchopulmonary dysplasia in preterm infants until studies showed increased risk of cerebral palsy and neurodevelopmental impairment. We aimed to describe PNC use in Europe and evaluate the determinants of their use, including neonatal characteristics and adherence to evidence-based practices in neonatal intensive care units (NICUs).METHODS: 3917/4096 (95,6%) infants born between 24 and 29 weeks gestational age in 19 regions of 11 European countries of the EPICE cohort we included. We examined neonatal characteristics associated with PNC use. The cohort was divided by tertiles of probability of PNC use determined by logistic regression analysis. We also evaluated the impact of the neonatal unit's reported adherence to European recommendations for respiratory management and a stated policy of reduced PNC use.RESULTS: PNC were prescribed for 545/3917 (13.9%) infants (regional range 3.1-49.4%) and for 29.7% of infants in the highest risk tertile (regional range 5.4-72.4%). After adjustment, independent predictors of PNC use were a low gestational age, small for gestational age, male sex, mechanical ventilation, use of non-steroidal anti-inflammatory drugs to treat persistent ductus arteriosus and region. A stated NICU policy reduced PNC use (odds ratio 0.29 [95% CI 0.17; 0.50]).CONCLUSIONS: PNC are frequently used in Europe, but with wide regional variation that was unexplained by neonatal characteristics. Even for infants at highest risk for PNC use, some regions only rarely prescribed PNC. A stated policy of reduced PNC use was associated with observed practice and is recommended.
Published: 2017

21. Use of magnesium sulfate before 32 weeks of gestation : A European population-based cohort study

Author: Wolf, H. T., Huusom, L., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, and Bonet, M.
Subjects: Severity of Illness Index, Cohort Studies, 0302 clinical medicine, PREVENTIVE MEDICINE, Pre-Eclampsia, Pregnancy, Obstetrics and Gynaecology, Eclampsia, 030212 general & internal medicine, Practice Patterns, Physicians', reproductive and urinary physiology, Medicine(all), education.field_of_study, 030219 obstetrics & reproductive medicine, Evidence-Based Medicine, Obstetrics, Medical record, General Medicine, Calcium Channel Blockers, female genital diseases and pregnancy complications, 3. Good health, Europe, Pregnancy Trimester, Second, embryonic structures, Population study, Gestation, Premature Birth, Female, Guideline Adherence, Cohort study, Adult, medicine.medical_specialty, HELLP Syndrome, Population, Gestational Age, 03 medical and health sciences, Magnesium Sulfate, Young Adult, Intensive care, medicine, Journal Article, Humans, education, Fetus, business.industry, Research, fungi, medicine.disease, equipment and supplies, business
Abstract: Objectives: The use of magnesium sulfate (MgSO4) in European obstetric units is unknown. We aimed to describe reported policies and actual use of MgSO4 in women delivering before 32 weeks of gestation by indication. Methods: We used data from the European Perinatal Intensive Care in Europe (EPICE) population-based cohort study of births before 32 weeks of gestation in 19 regions in 11 European countries. Data were collected from April 2011 to September 2012 from medical records and questionnaires. The study population comprised 720 women with severe preeclampsia, eclampsia or HELLP and 3658 without preeclampsia delivering from 24 to 31 weeks of gestation in 119 maternity units with 20 or more very preterm deliveries per year. Results: Among women with severe pre-eclampsia, eclampsia or HELLP, 255 (35.4%) received MgSO4 before delivery. 41% of units reported use of MgSO4 whenever possible for pre-eclampsia and administered MgSO4 more often than units reporting use sometimes. In women without pre-eclampsia, 95 (2.6%) received MgSO4. 9 units (7.6%) reported using MgSO4 for fetal neuroprotection whenever possible. In these units, the median rate of MgSO4 use for deliveries without severe pre-eclampsia, eclampsia and HELLP was 14.3%. Only 1 unit reported using MgSO4 as a first-line tocolytic. Among women without preeclampsia, MgSO4 use was not higher in women hospitalised before delivery for preterm labour. Conclusions: Severe pre-eclampsia, eclampsia or HELLP are not treated with MgSO4 as frequently as evidence-based medicine recommends. MgSO4 is seldom used for fetal neuroprotection, and is no longer used for tocolysis. To continuously lower morbidity, greater attention to use of MgSO4 is needed.
Published: 2017

22. Characteristics, management and outcomes of very preterm triplets in 19 European regions.

Author: Dudenhausen, Joachim W., Misselwitz, Björn, Piedvache, Aurelie, Maier, Rolf F., Weber, Tom, Zeitlin, Jennifer, Schmidt, Stephan, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Toome, L., Varendi, H., Ancel, P.Y., Blondel, B., Burguet, A., and Jarreau, P.H.
Published: 2019
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23. Association of Short Antenatal Corticosteroid Administration-to-Birth Intervals With Survival and Morbidity Among Very Preterm Infants: Results From the EPICE Cohort

Author: Norman, M., Piedvache, A., Borch, K., Huusom, L.D., Bonamy, A.E., Howell, E.A., Jarreau, P.H., Maier, R.F., Pryds, O., Toome, L., Varendi, H., Weber, T., Wilson, E., Heijst, A.F.J. van, Cuttini, M., Mazela, J., Barros, H., Reempts, P. Van, Draper, E.S., Zeitlin, J., Norman, M., Piedvache, A., Borch, K., Huusom, L.D., Bonamy, A.E., Howell, E.A., Jarreau, P.H., Maier, R.F., Pryds, O., Toome, L., Varendi, H., Weber, T., Wilson, E., Heijst, A.F.J. van, Cuttini, M., Mazela, J., Barros, H., Reempts, P. Van, Draper, E.S., and Zeitlin, J.
Abstract: Item does not contain fulltext, Importance: Administration-to-birth intervals of antenatal corticosteroids (ANS) vary. The significance of this variation is unclear. Specifically, to our knowledge, the shortest effective administration-to-birth interval is unknown. Objective: To explore the associations between ANS administration-to-birth interval and survival and morbidity among very preterm infants. Design, Setting, and Participants: The Effective Perinatal Intensive Care in Europe (EPICE) study, a population-based prospective cohort study, gathered data from 19 regions in 11 European countries in 2011 and 2012 on 4594 singleton infants with gestational ages between 24 and 31 weeks, without severe anomalies and unexposed to repeated courses of ANS. Data were analyzed November 2016. Exposure: Time from first injection of ANS to delivery in hours and days. Main Outcomes and Measures: Three outcomes were studied: in-hospital mortality; a composite of mortality or severe neonatal morbidity, defined as an intraventricular hemorrhage grade of 3 or greater, cystic periventricular leukomalacia, surgical necrotizing enterocolitis, or stage 3 or greater retinopathy of prematurity; and severe neonatal brain injury, defined as an intraventricular hemorrhage grade of 3 or greater or cystic periventricular leukomalacia. Results: Of the 4594 infants included in the cohort, 2496 infants (54.3%) were boys, and the mean (SD) gestational age was 28.5 (2.2) weeks and mean (SD) birth weight was 1213 (400) g. Mortality for the 662 infants (14.4%) unexposed to ANS was 20.6% (136 of 661). Administration of ANS was associated with an immediate and rapid decline in mortality, reaching a plateau with more than 50% risk reduction after an administration-to-birth interval of 18 to 36 hours. A similar pattern for timing was seen for the composite mortality or morbidity outcome, whereas a significant risk reduction of severe neonatal brain injury was associated with longer administration-to-birth intervals (greater than 48 ho
Published: 2017

24. Use of magnesium sulfate before 32 weeks of gestation: A European population-based cohort study

Author: MS Neonatologie, Brain, Arts-assistenten Kinderen, Wolf, H. T., Huusom, L., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Bonet, M., MS Neonatologie, Brain, Arts-assistenten Kinderen, Wolf, H. T., Huusom, L., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, and Bonet, M.
Published: 2017

25. Evidence-based neonatal unit practices and determinants of Postnatal corticosteroid-use in preterm births below 30 weeks ga in Europe: A population-based cohort study

Author: MS Neonatologie, Brain, Arts-assistenten Kinderen, Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., Piedvache, A., MS Neonatologie, Brain, Arts-assistenten Kinderen, Nuytten, Alexandra, Behal, Hélène, Duhamel, Alain, Jarreau, Pierre Henri, Mazela, Jan, Milligan, David, Gortner, Ludwig, Piedvache, Aurélie, Zeitlin, Jennifer, Truffert, Patrick, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Weber, T., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, T., Barros, H., Bonamy, A. K., Norman, M., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W A, Zeitlin, J., Bonet, M., and Piedvache, A.
Published: 2017

26. Use of magnesium sulfate before 32 weeks of gestation:A European population-based cohort study

Author: Wolf, H. T., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., Fenton, A. C., Wolf, H. T., Weber, T., Piedvache, A., Schmidt, S., Norman, M., Zeitlin, J., Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L., Pryds, O., Toome, L., Varendi, H., Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Cuttini, M., Koopman-Esseboom, C., Van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., MacHado, M. C., Rodrigues, C., Rodrigues, T., Barros, H., Bonamy, A. K., Wilson, E., Boyle, E., Draper, E. S., Manktelow, B. N., and Fenton, A. C.
Abstract: Objectives: The use of magnesium sulfate (MgSO4) in European obstetric units is unknown. We aimed to describe reported policies and actual use of MgSO4 in women delivering before 32 weeks of gestation by indication. Methods: We used data from the European Perinatal Intensive Care in Europe (EPICE) population-based cohort study of births before 32 weeks of gestation in 19 regions in 11 European countries. Data were collected from April 2011 to September 2012 from medical records and questionnaires. The study population comprised 720 women with severe preeclampsia, eclampsia or HELLP and 3658 without preeclampsia delivering from 24 to 31 weeks of gestation in 119 maternity units with 20 or more very preterm deliveries per year. Results: Among women with severe pre-eclampsia, eclampsia or HELLP, 255 (35.4%) received MgSO4 before delivery. 41% of units reported use of MgSO4 whenever possible for pre-eclampsia and administered MgSO4 more often than units reporting use sometimes. In women without pre-eclampsia, 95 (2.6%) received MgSO4. 9 units (7.6%) reported using MgSO4 for fetal neuroprotection whenever possible. In these units, the median rate of MgSO4 use for deliveries without severe pre-eclampsia, eclampsia and HELLP was 14.3%. Only 1 unit reported using MgSO4 as a first-line tocolytic. Among women without preeclampsia, MgSO4 use was not higher in women hospitalised before delivery for preterm labour. Conclusions: Severe pre-eclampsia, eclampsia or HELLP are not treated with MgSO4 as frequently as evidence-based medicine recommends. MgSO4 is seldom used for fetal neuroprotection, and is no longer used for tocolysis. To continuously lower morbidity, greater attention to use of MgSO4 is needed.
Published: 2017

27. Observational infant exploratory [14C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis

Author: Garner, C.R., Park, K.B., French, N.S., Earnshaw, C., Schipani, A., Selby, A.M., Byrne, L., Siner, S., Crawley, F.P., Vaes, W.H.J., Duijn, E. van, ligt, R. de, Varendi, H., Lass, J., Grynkiewicz, G., Maruszak, W., and Turner, M.A.
Subjects: Male, Ultra performance liquid chromatography, Exploratory clinical study, Unclassified drug, Drug half life, Major clinical study, Drug blood level, Volume of distribution, Life, Time to maximum plasma concentration, Pharmacokinetics, Paediatric pharmacokinetics, Child, Biology, Area under the curve, Mass spectrometry, Maximum plasma concentration, Plasma concentration-time curve, Infant, Accelerator mass spectrometry, Paracetamol, MSB - Microbiology and Systems Biology, Microdosing, Drug clearance, Female, ELSS - Earth, Life and Social Sciences, Healthy for Life, Healthy Living, Human
Abstract: Aims The aims of the study were to compare [14C]-paracetamol ([14C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AMS) bioanalysis in the 0-2 year old age group. Methods [14C]-PARA concentrations in 10-15 μl plasma samples were measured after enteral or i.v. administration of a single [14C]-PARA microdose or mixed in with therapeutic dose in infants receiving PARA as part of their therapeutic regimen. Results Thirty-four infants were included in the PARA PK analysis for this study: oral microdose (n = 4), i.v. microdose (n = 6), oral therapeutic (n = 6) and i.v. therapeutic (n = 18). The respective mean clearance (CL) values (SDs in parentheses) for these dosed groups were 1.46 (1.00) l h-1, 1.76 (1.07) l h-1, 2.93 (2.08) l h-1 and 2.72 (3.10) l h-1, t1/2 values 2.65 h, 2.55 h, 8.36 h and 7.16 h and dose normalized AUC(0-t) (mg l-1 h) values were 0.90 (0.43), 0.84 (0.57), 0.7 (0.79) and 0.54 (0.26). Conclusions All necessary ethical, scientific, clinical and regulatory procedures were put in place to conduct PK studies using enteral and systemic microdosing in two European centres. The pharmacokinetics of a therapeutic dose (mg kg-1) and a microdose (ng kg-1) in babies between 35 to 127 weeks post-menstrual age. [14C]-PARA pharmacokinetic parameters were within a two-fold range after a therapeutic dose or a microdose. Exploratory studies using doses significantly less than therapeutic doses may offer ethical and safety advantages with increased bionalytical sensitivity in selected exploratory paediatric pharmacokinetic studies. © 2015 The British Pharmacological Society.
Published: 2015

28. O-106 Populationpharmacokinetic Model Of The Antimicrobial Excipient Methyl Paraben Administered In Routine Clinical Practice To Neonates: Abstract O-106 Table 1

Author: Mulla, H, primary, Yakkundi, S, additional, McElnay, J, additional, Varendi, H, additional, Metsvaht, T, additional, Nellis, G, additional, Windrow, J, additional, Graham, S, additional, Tapscott, S, additional, Caldwell, NA, additional, Pandya, H, additional, Duncan, JC, additional, Lutsar, I, additional, Nunn, AJ, additional, and Turner, MA, additional
Published: 2014
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29. PO-0934 Comparative Paediatric Acetaminophen Pharmacokinetics Between A Microdose And A Therapeutic Dose Using Accelerator Mass Spectrometry Bioanalysis: Abstract PO-0934 Table 1

Author: Turner, MA, primary, Park, BK, additional, French, NS, additional, Earnshaw, C, additional, Schipani, A, additional, Selby, AM, additional, Byrne, L, additional, Siner, S, additional, Vaes, WHJ, additional, van Duijn, E, additional, de Ligt, RAF, additional, Varendi, H, additional, Lass, J, additional, Grynkiewicz, G, additional, Maruszak, W, additional, Crawley, F, additional, and Garner, RC, additional
Published: 2014
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30. PS-128 The Ethics Of Microdosing Studies In Children: The Experience Of The Era-net Priomedchild Project Pamper

Author: Crawley, F, primary, Vaes, WHJ, additional, Selby, A, additional, Varendi, H, additional, Turner, M, additional, Park, BK, additional, Byrne, L, additional, and Garner, RC, additional
Published: 2014
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31. An Observational Study of Blood Concentrations and Kinetics of Methyl- and Propyl-Parabens in Neonates

Author: Mulla, H., primary, Yakkundi, S., additional, McElnay, J., additional, Lutsar, I., additional, Metsvaht, T., additional, Varendi, H., additional, Nellis, G., additional, Nunn, A., additional, Duncan, J., additional, Pandya, H., additional, and Turner, M., additional
Published: 2014
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32. ABSTRACT 131

Author: Byrne, L., primary, Selby, A., additional, Siner, S., additional, Scott, E., additional, Garner, R.C., additional, Earnshaw, C., additional, French, N., additional, Schipani, A., additional, Grynkiewicz, G., additional, Maruszak, W., additional, Van Duijin, E., additional, Fabriek, B.O., additional, Vaes, W.H.J., additional, Varendi, H., additional, Lass, J., additional, Korgvee, L., additional, Park, K., additional, Solanki, K., additional, and Turner, M., additional
Published: 2014
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33. ABSTRACT 707

Author: Selby, A., primary, Byrne, L., additional, Siner, S., additional, Scott, E., additional, Garner, R.C., additional, Earnshaw, C., additional, French, N., additional, Schipani, A., additional, Grynkiewicz, G., additional, Maruszak, W., additional, van Duijn, E., additional, Fabriek, B.O., additional, Vaes, W.H.J., additional, Varendi, H., additional, Lass, J., additional, Korgvee, L., additional, Park, K., additional, and Turner, M., additional
Published: 2014
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34. Rôle des odeurs maternelles sur le comportement alimentaire du nouveau-né humain

Author: Porter, R.H., Varendi, H., Winberg, J., Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), C. Baudoin (Editeur), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS, RELATION MERE-JEUNE
Abstract: National audience
Published: 2003

35. Breast odour as the only maternal stimulus elicits crawling towards the odour source

Author: Varendi, H., Porter, R.H., Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2001

36. Soothing effect of amniotic fluid smell in newborn infants

Author: Varendi, H., Christensson, K., Porter, R.H., Winberg, J., ProdInra, Migration, Unité de recherche Physiologie de la reproduction des mammifères domestiques, Nouzilly, and Institut National de la Recherche Agronomique (INRA)
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS, APPRENTISSAGE
Abstract: International audience
Published: 1998

37. Natural odour preferences of newborn infants change over time

Author: Varendi, H., Porter, R.H., Winberg, J., Unité de recherche Physiologie de la reproduction des mammifères domestiques, Nouzilly, and Institut National de la Recherche Agronomique (INRA)
Subjects: [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 1997

38. Attractiveness of amniotic fluid odor: evidence of prenatal olfactory learning?

Author: Varendi, H., primary, Porter, RH, additional, and Winberg, J., additional
Published: 1996
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39. Acutely and retrospectively diagnosed perinatal stroke: a population-based study.

Author: Laugesaar R, Kolk A, Tomberg T, Metsvaht T, Lintrop M, Varendi H, Talvik T, Laugesaar, Rael, Kolk, Anneli, Tomberg, Tiiu, Metsvaht, Tuuli, Lintrop, Mare, Varendi, Heili, and Talvik, Tiina
Published: 2007
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40. Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age

Author: Piedvache, Aurélie, van Buuren, Stef, Barros, Henrique, Ribeiro, Ana Isabel, Draper, Elizabeth, Zeitlin, Jennifer, Martens, E., Martens, G., Van Reempts, P., Boerch, K., Hasselager, A., Huusom, L. D., Pryds, O., Weber, T., Toome, L., Varendi, H., France, Ile-de, Ancel, P. Y., Blondel, B., Burguet, A., Jarreau, P. H., Truffert, P., Maier, R. F., Misselwitz, B., Schmidt, S., Gortner, L., Baronciani, D., Gargano, G., Agostino, R., DiLallo, D., Franco, F., Carnielli, V., Koopman-Esseboom, C., van Heijst, A., Nijman, J., Gadzinowski, J., Mazela, J., Graça, L. M., Machado, M. C., Rodrigues, Carina, Rodrigues, T., Bonamy, A. K., Norman, M., Boyle, E. Wilson E, Draper, E. S., Manktelow, B. N., Fenton, A. C., Milligan, D. W. A., Zeitlin, J., Bonet, M., and Piedvache, A.
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41. Does the newborn baby find the nipple by smell?

Author: Varendi, H. and Porter, R.H.
Subjects: *NEWBORN infants
Abstract: Emphasizes the role of smell in the newborn baby's location of its mother's nipple.
Published: 1995

42. Maternal education and language development at 2 years corrected age in children born very preterm: results from a European population-based cohort study

Author: Mariane Sentenac, Samantha Johnson, Jennifer Zeitlin, Rolf F. Maier, Ulrika Ådén, Marina Cuttini, Anna-Veera Seppänen, Mairi Männamaa, Marie-Laure Charkaluk, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Health Sciences [Leicester], University of Leicester, Service de Néonatologie [GHIC Lille] (Faculté de Médecine et Maïeutique), Hôpital Saint Vincent de Paul de Lille, Groupe Hospitalier de l'Institut Catholique de Lille (GHICL)-Groupe Hospitalier de l'Institut Catholique de Lille (GHICL), Université catholique de Lille - Faculté de médecine et de maïeutique (UCL FMM), Université catholique de Lille (UCL), Department of Women's and Children's Health [Stockholm, Sweden], Karolinska University Hospital [Stockholm], Clinical Care and Management Innovation Research Area [Roma, Lazio, Italy], Children's Hospital Bambino Gesù IRCCS [Rome], Philipps University of Marburg, Department of Pediatrics [Tartu, Estonia], Children's Clinic of Tartu University Hospital-University of Tartu, EPICE group : Martens E, Martens G, Van Reempts P, Boerch K, Hasselager A, Huusom LD, Pryds O, Weber T, Toome L, Varendi H, Ancel PY, Blondel B, Burguet A, Jarreau PH, Truffert P, Maier RF, Misselwitz B, Schmidt S, Gortner L, Baronciani D, Gargan G, Agostino R, DiLallo D, Franco F, Carnielli V, Koopman-Esseboom C, van Heijst A, Nijman J, Gadzinowski J, Mazela J, Graça LM, Machado MC, Rodrigues C, Rodrigues T, Bonamy AK, Norman M, Wilson E, Boyle E, Draper ES, Manktelow BN, Fenton AC, Milligan DWA, Zeitlin J, Bonet M, Piedvache A., Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Tartu-Children's Clinic of Tartu University Hospital, Instituto de Saúde Pública da Universidade do Porto, Sentenac, Mariane, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université Catholique de Lille - Faculté de Médecine, Maïeutique, Sciences de la santé (FMMS), Institut Catholique de Lille (ICL), and Philipps Universität Marburg = Philipps University of Marburg
Subjects: Male, Epidemiology, Population, Mothers, Gestational Age, Language Development, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, 030225 pediatrics, Intensive care, medicine, Humans, 030212 general & internal medicine, Risk factor, education, Socioeconomic status, perinatal, education.field_of_study, social inequalities, business.industry, Public Health, Environmental and Occupational Health, Infant, Newborn, Gestational age, medicine.disease, Europe, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Preschool, Infant, Extremely Premature, Population Surveillance, Cohort, child health, Educational Status, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Demography, Cohort study
Abstract: Background Socioeconomic factors influence language development in the general population, but the association remains poorly documented in children born very preterm (VPT). We assessed the impact of maternal education on language development in children born VPT and effect modification by perinatal risk. Methods Data were from the Effective Perinatal Intensive Care in Europe (EPICE) population-based cohort of children born
Published: 2020

43. Atopy and asthma in children born to mothers at risk of gestational diabetes mellitus: a follow-up study.

Author: Bärenson A, Tagoma A, Varendi H, and Uibo R
Subjects: Humans, Pregnancy, Female, Follow-Up Studies, Child, Preschool, Adult, Infant, Risk Factors, Male, Rhinitis, Allergic epidemiology, Mothers statistics & numerical data, Diabetes, Gestational epidemiology, Asthma epidemiology, Asthma etiology, Dermatitis, Atopic epidemiology, Prenatal Exposure Delayed Effects epidemiology
Abstract: Background: Gestational diabetes mellitus (GDM) is the most prevalent metabolic disturbance during pregnancy and is associated with adverse outcomes in offspring, including an elevated risk for developing atopic diseases in early childhood. Research is limited regarding only women at risk of GDM among whom some develop GDM while others do not. Information about adverse health outcomes in the offspring of these women is also lacking. The main aim was to assess whether maternal GDM increases the offspring's risk of atopic dermatitis (AD), asthma and allergic rhinitis at 1, 2 and 5 years of age. The second aim was to analyze the association of other maternal health characteristics on the development of these disorders in offspring., Methods: The follow-up study group of the Gestational Diabetes Study (GDS), conducted at Tartu University Hospital, Estonia, between 2014 and 2020, comprised 223 mother-child dyads. All women had at least one risk factor for GDM, of whom only some developed GDM. Information about the diagnoses of interest was obtained from Electronic Health Records. Allergen-specific IgE from children's serum was measured using ImmunoCAP™ Phadiatop™ Infant, with results ≥ 0.35 kU/l considered positive. Statistical analysis was performed using the RStudio software (version 4.3.0)., Results: According to our results, only the cases of GDM requiring the use of antidiabetic medications were associated with the development of asthma and/or allergic rhinitis at 2 years of age (aOR 4.68, 95%CI 1.08-20.21, p = 0.039). Maternal obesity (BMI > 30) was associated with offspring´s asthma and/or allergic rhinitis diagnosis at 2 years of age (aOR 3.15, 95%CI 1.03-9.63, p = 0.045). Maternal abnormal weight gain during pregnancy was associated with asthma and/or allergic rhinitis at 5 years of age (aOR 2.76, 95%CI 1.04-7.31, p = 0.041)., Conclusion: Among pregnant women at risk for GDM, maternal weight-related factors significantly influence the development of atopic diseases in their children between 1 and 5 years of age, regardless of the GDM diagnosis. This suggests that, besides women with GDM greater attention should also be paid to women at risk but who do not develop GDM, as their children seem to be at higher risk of atopic diseases., (© 2024. The Author(s).)
Published: 2024
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44. Health-related quality of life at 5 years of age for children born very preterm with congenital anomalies: a multi-national cohort study.

Author: Kim SW, Tian X, Andronis L, Maier RF, Varendi H, Seppänen AV, Siljehav V, Draper ES, Zeitlin J, and Petrou S
Abstract: Background: This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies., Methods: The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares (OLS) regression were used to explore the associations between the presence and severity of congenital anomalies., Results: The mean total PedsQL™ GCS score for children with a mild congenital anomaly was lower than the respective value for children without a congenital anomaly by 3.7 points (p < 0.05), controlling for socioeconomic variables only; this effect was attenuated when accumulatively adjusting for perinatal characteristics (3.3 points (p < 0.05)) and neonatal morbidities (3.1 (p < 0.05)). The mean total PedsQL™ GCS scores for children who had a severe congenital anomaly were lower by 7.1 points (p < 0.001), 6.6 points (p < 0.001) and 6.0 points (p < 0.001) when accumulatively adjusting for socioeconomic, perinatal and neonatal variables, respectively., Conclusion: This study revealed that the presence and severity of congenital anomalies are significant predictors of HRQoL outcomes in children born very preterm., Impact: Children born very preterm with congenital anomalies experience poorer health-related quality of life (HRQoL) than their very preterm counterparts born without congenital anomalies. Increased severity of these anomalies compounds the negative impacts on HRQoL. Our findings can be used by stakeholders for clinical and planning purposes., (© 2024. The Author(s).)
Published: 2024
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45. Laryngeal Mask Airway in Neonatal Resuscitation: A Survey of the Union of European Neonatal and Perinatal Societies.

Author: Trevisanuto D, Gizzi C, Cavallin F, Beke A, Buonocore G, Charitou A, Cucerea M, Filipović-Grčić B, Jekova NG, Koç E, Saldanha J, Stoniene D, Varendi H, De Bernardo G, Madar J, Hogeveen M, Orfeo L, Mosca F, Vertecchi G, and Moretti C
Abstract: Introduction: Laryngeal mask airway (LMA) use in neonatal resuscitation is limited despite existing evidence and recommendations. This survey investigated the knowledge and experience of healthcare providers on the use of the LMA and explored barriers and solutions for implementation., Methods: This online, cross-sectional survey on LMA in neonatal resuscitation involved healthcare professionals of the Union of European Neonatal and Perinatal Societies (UENPS)., Results: A total of 858 healthcare professionals from 42 countries participated in the survey. Only 6% took part in an LMA-specific course. Some delivery rooms were not equipped with LMA (26.1%). LMA was mainly considered after the failure of a face mask (FM) or endotracheal tube (ET), while the first choice was limited to neonates with upper airway malformations. LMA and FM were considered easier to position but less effective than ET, while LMA was considered less invasive than ET but more invasive than FM. Participants felt less competent and experienced with LMA than FM and ET. The lack of confidence in LMA was perceived as the main barrier to its implementation in neonatal resuscitation. More training, supervision, and device availability in delivery wards were suggested as possible actions to overcome those barriers., Conclusion: Our survey confirms previous findings on limited knowledge, experience, and confidence with LMA, which is usually considered an option after the failure of FM/ET. Our findings highlight the need for increasing the availability of LMA in delivery wards. Moreover, increasing LMA training and having an LMA expert supervisor during clinical practice may improve the implementation of LMA use in neonatal clinical practice., (© 2024 The Author(s). Published by S. Karger AG, Basel.)
Published: 2024
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46. Pharmacokinetics of oral spironolactone in infants up to 2 years of age.

Author: Lass J, Leroux S, Kõrgvee LT, Varendi H, Kipper K, Takkis K, Aro R, Metsvaht T, Oselin K, Pfister M, Soeorg H, van den Anker J, and Lutsar I
Subjects: Child, Humans, Infant, Infant, Newborn, Body Weight, Canrenone pharmacokinetics, Mineralocorticoid Receptor Antagonists pharmacokinetics, Spironolactone pharmacokinetics, Tandem Mass Spectrometry
Abstract: Purpose: Spironolactone is a potassium sparing diuretic used for decades. Until now, pharmacokinetic (PK) studies of spironolactone have not been conducted in infants and therefore pediatric dosing is based on expert opinion. We aimed to describe the PK profiles of spironolactone and its main metabolites (7alpha-thiomethylspironolactone (TMS) and canrenone (CAN)) in infants up to two years of age., Methods: The PK of spironolactone and its main metabolites were evaluated following an oral administration of spironolactone (1 mg/kg/dose) to pediatric patients with chronic heart failure, ascites, and/or oedema. The plasma concentration of spironolactone and metabolites (TMS and CAN) was determined using an ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Based on rich sampling PK data, the estimation of population PK parameters was performed using nonlinear mixed-effects modelling software Monolix 2018R2., Results: A total of 150 spironolactone, 158 TMS, and 158 CAN concentrations from 23 patients (ages: 3 days-21 months; median weight 4.3 kg (2.2-12.6)) were available for PK analysis. A one-compartment model for spironolactone, TMS, and CAN best fitted the data. The median (range) of individual estimated apparent clearance values were 47.7 (11.9-138.1) L/h for spironolactone, 9.7 (1.5-66.9) L/h for TMS, and 1.0 (0.2-5.9) L/h for CAN. The disposition of spironolactone and metabolites was mainly affected by size of the patient: body weight explained 22% of inter-individual variability of spironolactone clearance. None of the undesirable effects of spironolactone was documented during the study period., Conclusion: The pharmacokinetics of spironolactone and its metabolites was highly variable between patients below 2 years of age. Body weight explained a significant part of this variability; this highlights the need to take it into account for dosing prescription in this population. (Clinical trial Registration Number 2013-001189-40)., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Published: 2024
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47. A Survey of the Union of European Neonatal and Perinatal Societies on Neonatal Respiratory Care in Neonatal Intensive Care Units.

Author: Moretti C, Gizzi C, Gagliardi L, Petrillo F, Ventura ML, Trevisanuto D, Lista G, Dellacà RL, Beke A, Buonocore G, Charitou A, Cucerea M, Filipović-Grčić B, Jeckova NG, Koç E, Saldanha J, Sanchez-Luna M, Stoniene D, Varendi H, Vertecchi G, and Mosca F
Abstract: (1) Background: Our survey aimed to gather information on respiratory care in Neonatal Intensive Care Units (NICUs) in the European and Mediterranean region. (2) Methods: Cross-sectional electronic survey. An 89-item questionnaire focusing on the current modes, devices, and strategies employed in neonatal units in the domain of respiratory care was sent to directors/heads of 528 NICUs. The adherence to the "European consensus guidelines on the management of respiratory distress syndrome" was assessed for comparison. (3) Results: The response rate was 75% (397/528 units). In most Delivery Rooms (DRs), full resuscitation is given from 22 to 23 weeks gestational age. A T-piece device with facial masks or short binasal prongs are commonly used for respiratory stabilization. Initial FiO 2 is set as per guidelines. Most units use heated humidified gases to prevent heat loss. SpO 2 and ECG monitoring are largely performed. Surfactant in the DR is preferentially given through Intubation-Surfactant-Extubation (INSURE) or Less-Invasive-Surfactant-Administration (LISA) techniques. DR caffeine is widespread. In the NICUs, most of the non-invasive modes used are nasal CPAP and nasal intermittent positive-pressure ventilation. Volume-targeted, synchronized intermittent positive-pressure ventilation is the preferred invasive mode to treat acute respiratory distress. Pulmonary recruitment maneuvers are common approaches. During NICU stay, surfactant administration is primarily guided by FiO 2 and SpO 2 /FiO 2 ratio, and it is mostly performed through LISA or INSURE. Steroids are used to facilitate extubation and prevent bronchopulmonary dysplasia. (4) Conclusions: Overall, clinical practices are in line with the 2022 European Guidelines, but there are some divergences. These data will allow stakeholders to make comparisons and to identify opportunities for improvement.
Published: 2024
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48. Depressive symptoms in mothers of preterm infants before and during COVID-19 restrictions in neonatal intensive care units.

Author: Itoshima R, Tuura K, Toome L, Varendi H, Saik P, Axelin A, Lehtonen L, and Ahlqvist-Björkroth S
Subjects: Female, Infant, Infant, Newborn, Humans, Infant, Premature, Mothers, Depression epidemiology, Intensive Care Units, Neonatal, Cohort Studies, Pandemics, Depression, Postpartum epidemiology, COVID-19 epidemiology
Abstract: Aim: Little is known about the specific restriction measures used in intensive care units (NICUs) during the COVID-19 pandemic and their impact on parental well-being. Hence, this study aimed to assess the association between restriction measures and mothers' post-partum depressive symptoms., Methods: This comparative cohort study included mothers who gave birth before 35 weeks of gestation in Estonia. The outcome measure was mothers' post-partum depressive symptoms at the time of infant discharge, evaluated using the Edinburgh Postnatal Depression Scale (EPDS). In addition to the pandemic itself, the number of restriction measures in the NICUs was analysed as a potential explanatory factor for depressive symptoms., Results: The study included 55 mothers before the pandemic in 2018-2019 and 54 mothers during the COVID-19 pandemic in 2021. No significant difference was found in the median EPDS scores between the cohorts: 7.0 [interquartile range (IQR): 4.0-12.0] and 8.0 (IQR: 5.0-12.8) respectively. The number of restriction measures was not associated with mothers' EPDS scores in either unadjusted or adjusted models., Conclusion: The COVID-19 pandemic or the number of restriction measures used in Estonian NICUs did not associate with mothers' post = partum depressive symptoms., (© 2023 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Published: 2023
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49. Apgar Score and Neurodevelopmental Outcomes at Age 5 Years in Infants Born Extremely Preterm.

Author: Ehrhardt H, Aubert AM, Ådén U, Draper ES, Gudmundsdottir A, Varendi H, Weber T, Zemlin M, Maier RF, and Zeitlin J
Subjects: Infant, Newborn, Child, Female, Pregnancy, Child, Preschool, Humans, Infant, Apgar Score, Cohort Studies, Cognition, Infant, Extremely Premature, Cerebral Palsy
Abstract: Importance: The Apgar score is used worldwide as an assessment tool to estimate the vitality of newborns in their first minutes of life. Its applicability to estimate neurodevelopmental outcomes in infants born extremely preterm (EPT; <28 weeks' gestation) is not well established., Objective: To investigate the association between the Apgar score and neurodevelopmental outcomes in infants born EPT., Design, Setting, and Participants: This cohort study was conducted using data from the Effective Perinatal Intensive Care in Europe-Screening to Improve Health in Very Preterm Infants in Europe (EPICE-SHIPS) study, a population-based cohort in 19 regions of 11 European countries in 2011 to 2012. Clinical assessments of cognition and motor function at age 5 years were performed in infants born EPT and analyzed in January to July 2023., Exposures: Apgar score at 5 minutes of life categorized into 4 groups (0-3, 4-6, 7-8, and 9-10 points)., Main Outcomes and Measures: Cognitive and motor outcomes were assessed using the Wechsler Preschool and Primary Scale of Intelligence test of IQ derived from locally normed versions by country and the Movement Assessment Battery for Children-Second Edition. Parents additionally provided information on communication and problem-solving skills using the Ages and Stages Questionnaire, third edition (ASQ-3). All outcomes were measured as continuous variables., Results: From the total cohort of 4395 infants born EPT, 2522 infants were live born, 1654 infants survived to age 5 years, and 996 infants (478 females [48.0%]) followed up had at least 1 of 3 outcome measures. After adjusting for sociodemographic variables, perinatal factors, and severe neonatal morbidities, there was no association of Apgar score with IQ, even for scores of 3 or less (β = -3.3; 95% CI, -10.5 to 3.8) compared with the score 9 to 10 category. Similarly, no association was found for ASQ-3 (β = -2.1; 95% CI, -24.6 to 20.4). Congruent results for Apgar scores of 3 or less were obtained for motor function scores for all children (β = -4.0; 95% CI, -20.1 to 12.1) and excluding children with a diagnosis of cerebral palsy (β = 0.8, 95% CI -11.7 to 13.3)., Conclusions and Relevance: This study found that low Apgar scores were not associated with longer-term outcomes in infants born EPT. This finding may be associated with high interobserver variability in Apgar scoring, reduced vitality signs and poorer responses to resuscitation after birth among infants born EPT, and the association of more deleterious exposures in the neonatal intensive care unit or of socioeconomic factors with greater changes in outcomes during the first 5 years of life.
Published: 2023
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50. Variation in delivery room management of preterm infants across Europe: a survey of the Union of European Neonatal and Perinatal Societies.

Author: Gizzi C, Gagliardi L, Trevisanuto D, Ghirardello S, Di Fabio S, Beke A, Buonocore G, Charitou A, Cucerea M, Degtyareva MV, Filipović-Grčić B, Jekova NG, Koç E, Saldanha J, Luna MS, Stoniene D, Varendi H, Calafatti M, Vertecchi G, Mosca F, and Moretti C
Abstract: The aim of the present study, endorsed by the Union of European Neonatal and Perinatal Societies (UENPS) and the Italian Society of Neonatology (SIN), was to analyze the current delivery room (DR) stabilization practices in a large sample of European birth centers that care for preterm infants with gestational age (GA) < 33 weeks. Cross-sectional electronic survey was used in this study. A questionnaire focusing on the current DR practices for infants < 33 weeks' GA, divided in 6 neonatal resuscitation domains, was individually sent to the directors of European neonatal facilities, made available as a web-based link. A comparison was made between hospitals grouped into 5 geographical areas (Eastern Europe (EE), Italy (ITA), Mediterranean countries (MC), Turkey (TUR), and Western Europe (WE)) and between high- and low-volume units across Europe. Two hundred and sixty-two centers from 33 European countries responded to the survey. At the time of the survey, approximately 20,000 very low birth weight (VLBW, < 1500 g) infants were admitted to the participating hospitals, with a median (IQR) of 48 (27-89) infants per center per year. Significant differences between the 5 geographical areas concerned: the volume of neonatal care, ranging from 86 (53-206) admitted VLBW infants per center per year in TUR to 35 (IQR 25-53) in MC; the umbilical cord (UC) management, being the delayed cord clamping performed in < 50% of centers in EE, ITA, and MC, and the cord milking the preferred strategy in TUR; the spotty use of some body temperature control strategies, including thermal mattress mainly employed in WE, and heated humidified gases for ventilation seldom available in MC; and some of the ventilation practices, mainly in regard to the initial FiO 2 for < 28 weeks' GA infants, pressures selected for ventilation, and the preferred interface to start ventilation. Specifically, 62.5% of TUR centers indicated the short binasal prongs as the preferred interface, as opposed to the face mask which is widely adopted as first choice in > 80% of the rest of the responding units; the DR surfactant administration, which ranges from 44.4% of the birth centers in MC to 87.5% in WE; and, finally, the ethical issues around the minimal GA limit to provide full resuscitation, ranging from 22 to 25 weeks across Europe. A comparison between high- and low-volume units showed significant differences in the domains of UC management and ventilation practices. Conclusion: Current DR practice and ethical choices show similarities and divergences across Europe. Some areas of assistance, like UC management and DR ventilation strategies, would benefit of standardization. Clinicians and stakeholders should consider this information when allocating resources and planning European perinatal programs. What is Known: • Delivery room (DR) support of preterm infants has a direct influence on both immediate survival and long-term morbidity. • Resuscitation practices for preterm infants often deviate from the internationally defined algorithms. What is New: • Current DR practice and ethical choices show similarities and divergences across Europe. Some areas of assistance, like UC management and DR ventilation strategies, would benefit of standardization. • Clinicians and stakeholders should consider this information when allocating resources and planning European perinatal programs., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Published: 2023
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