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Wide variation in severe neonatal morbidity among very preterm infants in european regions

Authors :
Edstedt Bonamy, A-K. (Anna-Karin)
Zeitlin, J. (Jennifer)
Piedvache, A. (Aurelie)
Maier, R.F. (Rolf F.)
Van Heijst, A. (Arno)
Varendi, H. (Heili)
Manktelow, B.N. (Bradley N.)
Fenton, A. (Alan)
Mazela, J. (Jan)
Cuttini, M. (Marina)
Norman, M. (Mikael)
Petrou, S. (Stavros)
Van Reempts, P. (Patrick)
Barros, H. (Henrique)
Draper, E.S. (Elizabeth S.)
Martens, E. (E.)
Martens, G. (G.)
Boerch, K. (K.)
Hasselager, A. (A.)
Huusom, L. (L.)
Pryds, O. (O.)
Weber, T. (Tom)
Toome, L. (Liis)
Ancel, P-Y. (Pierre-Yves)
Blondel, B. (Béatrice)
Burguet, A. (Antoine)
Jarreau, P-H. (Pierre-Henri)
Truffert, P. (Patrick)
Schmidt, S. (S.)
Gortner, L. (Ludwig)
Baronciani, D. (D.)
Gargano, G. (G.)
Agostino, R. (R.)
Dilallo, D. (D.)
Franco, F. (F.)
Carnielli, V. (V.)
Koopman-Esseboom, C. (C.)
Nijman, J. (J.)
Gadzinowski, J. (Janusz)
Graca, L.M. (L. M.)
Machado, M.C. (M. C.)
Rodrigues, C. (Carina)
Rodrigues, T. (T.)
Wilson, E. (Emilija)
Boyle, E.M. (Eileen Mary)
Milligan, D.W.A. (D. W. A.)
Bonet, M. (Mercedes)
CHU Lille
Université de Lille
Karolinska Institutet [Stockholm]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)]
Radboud University Medical Center [Nijmegen]
University of Tartu
University of Leicester
Newcastle University [Newcastle]
IRCCS Ospedale Pediatrico Bambino Gesù [Roma]
Poznan University of Medical Sciences [Poland] [PUMS]
University of Warwick [Coventry]
University of Antwerp [UA]
Hvidovre Hospital
Université Paris Descartes - Paris 5 [UPD5]
CHU Dijon
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Saarland University [Saarbrücken]
Istituto Nazionale di Riposo e Cura per Anziani di Ancona
University Medical Center [Utrecht]
Université de Lisbonne
Hospital de São João [Porto]
Karolinska University Hospital [Stockholm]
Royal Victoria Hospital
Publication Year :
2019

Abstract

OBJECTIVE: To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. METHODS: Area-based cohort study of all births before 32 weeks of gestational age. METHODS: 16 regions in 11 European countries in 2011/2012. METHODS: Survivors to discharge from neonatal care (n=6422). METHODS: Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. Common definitions for neonatal morbidities were established before data abstraction from medical records. Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. RESULTS: 10.6% of survivors had a severe neonatal morbidity without severe BPD (regional range 6.4%-23.5%) and 13.8% including severe BPD (regional range 10.0%-23.5%). Adjusted inhospital mortality was 13.7% (regional range 8.4%-18.8%). Differences between regions remained significant after consideration of maternal and neonatal characteristics (P

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.od......4198..5aa55965abad6a2fefe5c8d34be606fd