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Your search keyword '"Valentí Puig Divi"' showing total 4 results
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4 results on '"Valentí Puig Divi"'

1. Vitamin E and Vitamin E Acetate Absorption from Self-assembly Systems under Pancreas Insufficiency Conditions

Author

Kornél Nagy, Birgit Holst, Javier Santos, Martin Kussmann, Laurent Sagalowicz, Simone Acquistapace, Julie Moulin, Maurice Beaumont, Juan Ramón Malagelada, Fernando Azpiroz, Valentí Puig-Divi, Laura Ramos, Sophie Braga-Lagache, Marie-Claude Courtet-Compondu, Beatriz Lobo, and Gary Williamson

Subjects
Bioavailability, Chronic pancreas insufficiency, Self-assembly systems, Vitamin e, Chemistry, QD1-999
Abstract

We determined the bioavailability of vitamin E from self-assembly structures in patients with diagnosed chronic pancreas insufficiency. Vitamin E solubilized in dispersed inverted bicontinuous cubic phase and in micellar formulation was delivered directly to the small intestine by tube-feeding. A cross-over study with randomization of 6 subjects and 2 treatments including a combined dose of 18 mg (27 IU) of vitamin E (RRR-[5,7-methyl-(2H6)]-?-tocopherol) and 27 mg (27 IU) vitamin E acetate (RRR-[5-methyl-2H3]-?-tocopheryl acetate) was applied over a time period of 1 h. Plasma samples were collected for 56 h and analyzed by liquid chromatography–mass spectrometry. Appearance of labeled tocopherols originating from the treatment started at 25 h and reached Cmax (0.6–4.6 ?M depending on subject) in the 7–9 h window. From the Tmax onwards, both forms of tocopherols diminished slowly to 30–50% of their maxima within 56 h. Strong inter-individual variation was observed in the plasma appearance curves (relative standard deviation varied between 38–45%). No significant discrimination was found between the absorption of free or acetylated forms of deuterated ?-tocopherol confirming that application of acetylated ?-tocopherol provides the same bioavailability as free ?-tocopherol. This observation is valid in both dispersed inverted bicontinuous cubic phase and micellar formulations. Furthermore, since the area-under-the-curve values from cubic phase and from micellar formulations are similar, the cubic phase formulation could represent an alternative delivery system for lipophilic micronutrients in conditions or studies where polysorbate-based micelles cannot be generated.

Published
2014
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3. Valoración de las alteraciones de la función anorrectal en el postoperatorio inmediato y tardío tras la microcirugía transanal endoscópica

Author

Rubén Hernando Tavira, Manuel Alcántara Moral, Javier Aracil, Isidro Ayguavives Garnica, Judith Hermoso Bosch, Jordi Bombardó Juncá, Valentí Puig Divi, Pere Rebasa Cladera, Salvador Navarro Soto, and Laura Mora López

Subjects
business.industry, Medicine, Surgery, business, Humanities
Abstract

Resumen Introduccion y objetivo La microcirugia transanal endoscopica (TEM) es una tecnica innovadora que permite la escision local de lesiones rectales, benignas y malignas en fase inicial con mayores ventajas tecnicas y menor morbimortalidad que mediante las tecnicas habituales. Precisa de un utillaje especifico; destaca un rectoscopio de 4 cm de diametro que provoca una dilatacion anal mantenida. El objetivo de nuestro estudio es comprobar los efectos de la TEM en la funcionalidad anorrectal. Material y metodos Se incluyo a todos los pacientes intervenidos por via TEM a los que se les realizo una manometria y un cuestionario de continencia anal preoperatoria y a las 3 semanas y 4 meses postoperatorios. Se valoraron las variaciones en la presion basal (PB) y en la presion de contraccion voluntaria (PCV); tambien las variaciones en el cuestionario de continencia anal. Resultados Se intervino a 68 pacientes entre junio de 2004 y agosto de 2006. Al analizar la PB y la PCV preoperatorias (38,89; 126,28) se observo una disminucion estadisticamente significativa de ambas presiones a las 3 semanas (26,61; 104,75) que retorna a valores basales a los 4 meses (33,81; 118,9). No hubo variaciones en la prueba de continencia anal ni relacion entre la variacion de las presiones y el tiempo quirurgico. Conclusion La TEM produce una alteracion manometrica estadisticamente significativa que se normaliza a los 4 meses y que no se traduce en ninguna alteracion clinica en el postoperatorio inmediato ni en el tardio y, por tanto, es una tecnica segura que no produce alteraciones en la funcionalidad anorrectal.

Published
2007
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4. [Anorectal disorders in the immediate and late postoperative period after transanal endoscopic microsurgery]

Author

Laura, Mora López, Javier, Serra Aracil, Pere, Rebasa Cladera, Valentí, Puig Divi, Judith, Hermoso Bosch, Jordi, Bombardo Junca, Manuel, Alcántara Moral, Rubén, Hernando Tavira, Isidro, Ayguavives Garnica, and Salvador, Navarro Soto

Subjects
Adult, Aged, 80 and over, Male, Microsurgery, Time Factors, Manometry, Proctoscopes, Rectal Neoplasms, Anal Canal, Middle Aged, Proctoscopy, Postoperative Complications, Data Interpretation, Statistical, Surveys and Questionnaires, Humans, Female, Fecal Incontinence, Aged, Follow-Up Studies
Abstract

Transanal endoscopic microsurgery (TEM) is a new technique for local excision of benign and incipient malignant rectal lesions. This technique offers technological advantages over other procedures and is associated with lower morbidity and mortality. TEM involves prolonged dilatation of the anal sphincter with a large-diameter (4 cm) operating rectoscope. The aim of the present study was to assess the effects of TEM on anorectal function.All patients undergoing TEM were included. Continence was scored by a numeric scale and anorectal manometry before surgery and 3 weeks and 4 months after surgery. Variations in anal resting pressure, maximal anal resting pressure and the anal continence questionnaire were evaluated.Sixty-eight patients underwent TEM between June 2004 and August 2006. Mean anal resting pressure (ARP) and maximal anal resting pressure (MARP) were significantly reduced at 3 weeks after surgery (ARP/MARP before surgery: 38.89/126.28; 3 weeks after surgery: 26.61/104.75). No significant change was found in the mean continence score. No association was found between variation in pressures and operating time.TEM produced statistically significant alterations in anorectal physiology studies which returned to normal at 4 months. The technique did not affect continence scores in the immediate or late postoperative period and consequently can be considered a safe procedure that does not produce significant alterations in anorectal function.

Published
2007

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