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1. Glycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study

Author: Sieri, Sabina, Agnoli, Claudia, Grioni, Sara, Weiderpass, Elisabete, Mattiello, Amalia, Sluijs, Ivonne, Sanchez, Maria Jose, Jakobsen, Marianne Uhre, Sweeting, Michael, van der Schouw, Yvonne T, Nilsson, Lena Maria, Wennberg, Patrik, Katzke, Verena A, Kühn, Tilman, Overvad, Kim, Tong, Tammy YN, Conchi, Moreno-Iribas, Quirós, José Ramón, García-Torrecillas, Juan Manuel, Mokoroa, Olatz, Gómez, Jesús-Humberto, Tjønneland, Anne, Sonestedt, Emiliy, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Boer, Jolanda MA, Verschuren, WM Monique, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Madika, Anne-Laure, Bergmann, Manuela M, Schulze, Matthias B, Ferrari, Pietro, Freisling, Heinz, Lennon, Hannah, Sacerdote, Carlotta, Masala, Giovanna, Tumino, Rosario, Riboli, Elio, Wareham, Nicholas J, Danesh, John, Forouhi, Nita G, Butterworth, Adam S, and Krogh, Vittorio
Published: 2020
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2. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A, Hémon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kühn, Tilman, Boeing, Heiner, Förster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra HM, Bueno-de-Mesquita, H Bas, Engeset, Dagrun, Skeie, Guri, Hjartåker, Anette, Menéndez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Huerta, José María, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J, Khaw, Kay-Thee, Wareham, Nicholas J, Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, and Scalbert, Augustin
Subjects: Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Complementary and Integrative Health, Nutrition, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Cancer, Adult, Aged, Body Mass Index, Coffee, Cross-Sectional Studies, Diet, Europe, Exercise, Female, Flavonoids, Food Analysis, Food Handling, Fruit, Humans, Hydroxybenzoates, Life Style, Male, Mental Recall, Middle Aged, Nutrition Assessment, Polyphenols, Proanthocyanidins, Prospective Studies, Socioeconomic Factors, Tea, Dietary intake, EPIC, Food sources, Nutrition & Dietetics, Nutrition and dietetics, Epidemiology
Abstract: Background/objectivesPolyphenols are plant secondary metabolites with a large variability in their chemical structure and dietary occurrence that have been associated with some protective effects against several chronic diseases. To date, limited data exist on intake of polyphenols in populations. The current cross-sectional analysis aimed at estimating dietary intakes of all currently known individual polyphenols and total intake per class and subclass, and to identify their main food sources in the European Prospective Investigation into Cancer and Nutrition cohort.MethodsDietary data at baseline were collected using a standardized 24-h dietary recall software administered to 36,037 adult subjects. Dietary data were linked with Phenol-Explorer, a database with data on 502 individual polyphenols in 452 foods and data on polyphenol losses due to cooking and food processing.ResultsMean total polyphenol intake was the highest in Aarhus-Denmark (1786 mg/day in men and 1626 mg/day in women) and the lowest in Greece (744 mg/day in men and 584 mg/day in women). When dividing the subjects into three regions, the highest intake of total polyphenols was observed in the UK health-conscious group, followed by non-Mediterranean (non-MED) and MED countries. The main polyphenol contributors were phenolic acids (52.5-56.9 %), except in men from MED countries and in the UK health-conscious group where they were flavonoids (49.1-61.7 %). Coffee, tea, and fruits were the most important food sources of total polyphenols. A total of 437 different individual polyphenols were consumed, including 94 consumed at a level >1 mg/day. The most abundant ones were the caffeoylquinic acids and the proanthocyanidin oligomers and polymers.ConclusionThis study describes the large number of dietary individual polyphenols consumed and the high variability of their intakes between European populations, particularly between MED and non-MED countries.
Published: 2016

3. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author: Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-de-Mesquita, HB As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria-Dolores, Dorronsoro, Miren, Quirós, J Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay-Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda
Subjects: Biomedical and Clinical Sciences, Nutrition and Dietetics, Hepatitis, Infectious Diseases, Hepatitis - B, Liver Cancer, Prevention, Liver Disease, Cancer, Chronic Liver Disease and Cirrhosis, Rare Diseases, Nutrition, Digestive Diseases, Clinical Research, Emerging Infectious Diseases, Detection, screening and diagnosis, 4.1 Discovery and preclinical testing of markers and technologies, Good Health and Well Being, Adult, Aged, Carcinoma, Hepatocellular, Case-Control Studies, Diet, Dietary Fats, Europe, Feeding Behavior, Female, Humans, Incidence, Life Style, Liver Neoplasms, Male, Middle Aged, Nutritional Status, Prospective Studies, Risk, Risk Factors, Surveys and Questionnaires, Young Adult, European populations, cohort study, dietary fats, hepatocellular carcinoma, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract: The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.
Published: 2015

4. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Zamora-Ros, Raul, Cayssials, Valerie, Jenab, Mazda, Rothwell, Joseph A., Fedirko, Veronika, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elissavet, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Weiderpass, Elisabete, Lukic, Marko, Sandanger, Torkjel M., Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Navarro, Carmen, Ardanaz, Eva, Sonestedt, Emily, Ohlsson, Bodil, Nilsson, Lena Maria, Rutegård, Martin, Bueno-de-Mesquita, Bas, Peeters, Petra H., Khaw, Kay-Thee, Wareham, Nicholas J., Bradbury, Kathryn, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J., Vineis, Paolo, and Scalbert, Augustin
Published: 2018
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5. Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort

Author: Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael, Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobias, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C, Tjønneland, Anne, Bouton-Ruault, Marie-Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, van Vulpen, Jonna, Benjaminsen Borch, Kristin, Oluwafemi Oyeyemi, Sunday, Quirós, Ramón J, Bonet, Catalina, Sánchez, María-José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J, Khaw, Kay-Tee, Wareham, Nicholas, Assi, Nada, Ward, Heather A, Aune, Dagfinn, Riboli, Elio, and Boeing, Heiner
Published: 2017
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6. Meat and heme iron intake and esophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study

Author: Jakszyn, Paula, Luján-Barroso, Leila, Agudo, Antonio, Bueno-de-Mesquita, Bas H., Molina, Esther, Sánchez, M José, Fonseca-Nunes, Ana, Siersema, Peter D, Matiello, Amalia, Tumino, Rosario, Saieva, Calogero, Pala, Valeria, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadie, Travis, Ruth C., Khaw, Kay-Tee, Riboli, Elio, Murphy, Neil, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Valanou, Elissavet, Oikonomidou, Despina E, Weiderpass, Elisabete, Skeie, Guri, Johansen, Dorthe, Lindkvist, Björn, Johansson, Mattias, Duarte-Salles, Talita, Freisling, Heinz, Barricarte, Aurelio, M Huerta, Jose, Amiano, Pilar, Tjonneland, Anne, Overvad, Kim, Kuehn, Tilman, Grote, Verena, Boeing, Heiner, Peeters, Petra HM, and González, Carlos A
Published: 2013
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7. Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study

Author: Rinaldi, Sabina, Lise, Mauro, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Guillas, Gwenaelle, Overvad, Kim, Tjnneland, Anne, Halkjær, Jytte, Lukanova, Annekatrin, Kaaks, Rudolf, Bergmann, Manuela M., Boeing, Heiner, Trichopoulou, Antonia, Zylis, Dimosthenis, Valanou, Elissavet, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Polidoro, Silvia, Mattiello, Amalia, Bas Bueno-de-Mesquita, H., Peeters, Petra H., Weiderpass, Elisabete, Lund, Eiliv, Skeie, Guri, Rodríguez, Laudina, Travier, Noemie, Sánchez, Maria-José, Amiano, Pilar, Huerta, José-María, Ardanaz, Eva, Rasmuson, Torgny, Hallmans, Göran, Almquist, Martin, Manjer, Jonas, Tsilidis, Konstantinos K., Allen, Naomi E., Khaw, Kay-Tee, Wareham, Nick, Byrnes, Graham, Romieu, Isabelle, Riboli, Elio, and Franceschi, Silvia
Published: 2012
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8. Glycemic index, glycemic load, and risk of coronary heart disease:A pan-European cohort study

Author: Sieri, Sabina, Agnoli, Claudia, Grioni, Sara, Weiderpass, Elisabete, Mattiello, Amalia, Sluijs, Ivonne, Sanchez, Maria Jose, Jakobsen, Marianne Uhre, Sweeting, Michael, van der Schouw, Yvonne T., Nilsson, Lena Maria, Wennberg, Patrik, Katzke, Verena A., Kühn, Tilman, Overvad, Kim, Tong, Tammy Y.N., Conchi, Moreno Iribas, Quirós, José Ramón, García-Torrecillas, Juan Manuel, Mokoroa, Olatz, Gómez, Jesús Humberto, Tjønneland, Anne, Sonestedt, Emiliy, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Boer, Jolanda M.A., Monique Verschuren, W. M., Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Madika, Anne Laure, Bergmann, Manuela M., Schulze, Matthias B., Ferrari, Pietro, Freisling, Heinz, Lennon, Hannah, Sacerdote, Carlotta, Masala, Giovanna, Tumino, Rosario, Riboli, Elio, Wareham, Nicholas J., Danesh, John, Forouhi, Nita G., Butterworth, Adam S., Krogh, Vittorio, Sieri, Sabina, Agnoli, Claudia, Grioni, Sara, Weiderpass, Elisabete, Mattiello, Amalia, Sluijs, Ivonne, Sanchez, Maria Jose, Jakobsen, Marianne Uhre, Sweeting, Michael, van der Schouw, Yvonne T., Nilsson, Lena Maria, Wennberg, Patrik, Katzke, Verena A., Kühn, Tilman, Overvad, Kim, Tong, Tammy Y.N., Conchi, Moreno Iribas, Quirós, José Ramón, García-Torrecillas, Juan Manuel, Mokoroa, Olatz, Gómez, Jesús Humberto, Tjønneland, Anne, Sonestedt, Emiliy, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Boer, Jolanda M.A., Monique Verschuren, W. M., Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Madika, Anne Laure, Bergmann, Manuela M., Schulze, Matthias B., Ferrari, Pietro, Freisling, Heinz, Lennon, Hannah, Sacerdote, Carlotta, Masala, Giovanna, Tumino, Rosario, Riboli, Elio, Wareham, Nicholas J., Danesh, John, Forouhi, Nita G., Butterworth, Adam S., and Krogh, Vittorio
Abstract: Background: High carbohydrate intake raises blood triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (CHD). Epidemiological studies indicate that high dietary glycemic index (GI) and glycemic load (GL) are associated with increased CHD risk. Objectives: The aim of this study was to determine whether dietary GI, GL, and available carbohydrates are associated with CHD risk in both sexes. Methods: This large prospective study-the European Prospective Investigation into Cancer and Nutrition-consisted of 338,325 participants who completed a dietary questionnaire. HRs with 95% CIs for a CHD event, in relation to intake of GI, GL, and carbohydrates, were estimated using covariate-adjusted Cox proportional hazard models. Results: After 12.8 y (median), 6378 participants had experienced a CHD event. High GL was associated with greater CHD risk [HR 1.16 (95% CI: 1.02, 1.31) highest vs. lowest quintile, p-trend 0.035; HR 1.18 (95% CI: 1.07, 1.29) per 50 g/day of GL intake]. The association between GL and CHD risk was evident in subjects with BMI (in kg/m2) =25 [HR: 1.22 (95% CI: 1.11, 1.35) per 50 g/d] but not in those with BMI <25 [HR: 1.09 (95% CI: 0.98, 1.22) per 50 g/d) (P-interaction = 0.022). The GL-CHD association did not differ between men [HR: 1.19 (95% CI: 1.08, 1.30) per 50 g/d] and women [HR: 1.22 (95% CI: 1.07, 1.40) per 50 g/d] (test for interaction not significant). GI was associated with CHD risk only in the continuous model [HR: 1.04 (95% CI: 1.00, 1.08) per 5 units/d]. High available carbohydrate was associated with greater CHD risk [HR: 1.11 (95% CI: 1.03, 1.18) per 50 g/d]. High sugar intake was associated with greater CHD risk [HR: 1.09 (95% CI: 1.02, 1.17) per 50 g/d]. Conclusions: This large pan-European study provides robust additional support for the hypothesis that a diet that induces a high glucose response is associated with greater CHD risk.
Published: 2020

9. Glycemic index, glycemic load, and risk of coronary heart disease: a pan-European cohort study

Author: Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, UMC Utrecht, Public Health Epidemiologie, Sieri, Sabina, Agnoli, Claudia, Grioni, Sara, Weiderpass, Elisabete, Mattiello, Amalia, Sluijs, Ivonne, Sanchez, Maria Jose, Jakobsen, Marianne Uhre, Sweeting, Michael, van der Schouw, Yvonne T., Nilsson, Lena Maria, Wennberg, Patrik, Katzke, Verena A., Kuhn, Tilman, Overvad, Kim, Tong, Tammy Y. N., Conchi, Moreno-Iribas, Ramon Quiros, Jose, Manuel Garcia-Torrecillas, Juan, Mokoroa, Olatz, Gomez, Jesus-Humberto, Tjonneland, Anne, Sonestedt, Emiliy, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Boer, Jolanda M. A., Verschuren, W. M. Monique, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Madika, Anne-Laure, Bergmann, Manuela M., Schulze, Matthias B., Ferrari, Pietro, Freisling, Heinz, Lennon, Hannah, Sacerdote, Carlotta, Masala, Giovanna, Tumino, Rosario, Riboli, Elio, Wareham, Nicholas J., Danesh, John, Forouhi, Nita G., Butterworth, Adam S., Krogh, Vittorio, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, UMC Utrecht, Public Health Epidemiologie, Sieri, Sabina, Agnoli, Claudia, Grioni, Sara, Weiderpass, Elisabete, Mattiello, Amalia, Sluijs, Ivonne, Sanchez, Maria Jose, Jakobsen, Marianne Uhre, Sweeting, Michael, van der Schouw, Yvonne T., Nilsson, Lena Maria, Wennberg, Patrik, Katzke, Verena A., Kuhn, Tilman, Overvad, Kim, Tong, Tammy Y. N., Conchi, Moreno-Iribas, Ramon Quiros, Jose, Manuel Garcia-Torrecillas, Juan, Mokoroa, Olatz, Gomez, Jesus-Humberto, Tjonneland, Anne, Sonestedt, Emiliy, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Boer, Jolanda M. A., Verschuren, W. M. Monique, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Madika, Anne-Laure, Bergmann, Manuela M., Schulze, Matthias B., Ferrari, Pietro, Freisling, Heinz, Lennon, Hannah, Sacerdote, Carlotta, Masala, Giovanna, Tumino, Rosario, Riboli, Elio, Wareham, Nicholas J., Danesh, John, Forouhi, Nita G., Butterworth, Adam S., and Krogh, Vittorio
Published: 2020

10. Reproductive and Lifestyle Factors and Circulating sRANKL and OPG Concentrations in Women: Results from the EPIC Cohort

Author: Sarink, Danja, primary, Yang, Jiaxi, additional, Johnson, Theron, additional, Chang-Claude, Jenny, additional, Overvad, Kim, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Fournier, Agnès, additional, Mancini, Francesca Romana, additional, Kvaskoff, Marina, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Valanou, Elissavet, additional, Agnoli, Claudia, additional, Sacerdote, Carlotta, additional, Masala, Giovanna, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Van Gils, Carla H., additional, Skeie, Guri, additional, Gram, Inger Torhild, additional, Weiderpass, Elisabete, additional, Lujan-Barroso, Leila, additional, Petrova, Dafina, additional, Santiuste, Carmen, additional, Quirós, J. Ramón, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Travis, Ruth C., additional, Gunter, Marc, additional, Dossus, Laure, additional, Christakoudi, Sofia, additional, Kaaks, Rudolf, additional, and Fortner, Renée Turzanski, additional
Published: 2019
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11. Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study

Author: Cirera, Lluís, primary, Huerta, José María, additional, Chirlaque, María Dolores, additional, Overvad, Kim, additional, Lindström, Martin, additional, Regnér, Sara, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Rebours, Vinciane, additional, Fagherazzi, Guy, additional, Katzke, Verena A., additional, Boeing, Heiner, additional, Peppa, Eleni, additional, Trichopoulou, Antonia, additional, Valanou, Elissavet, additional, Palli, Domenico, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, van Gils, Carla, additional, Vermeulen, Roel C.H., additional, Skeie, Guri, additional, Braaten, Tonje, additional, Weiderpass, Elisabete, additional, Merino, Susana, additional, Sánchez, María José, additional, Larrañaga, Nerea, additional, Ardanaz, Eva, additional, Sund, Malin, additional, Khaw, Kay-Tee, additional, Key, Timothy J., additional, Jenab, Mazda, additional, Naudin, Sabine, additional, Murphy, Neil, additional, Aune, Dagfinn, additional, Ward, Heather, additional, Riboli, Elio, additional, Bueno-de-Mesquita, Bas, additional, Navarro, Carmen, additional, and Duell, Eric J., additional
Published: 2019
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12. Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe : An Update on the EPIC Cohorts Study

Author: Cirera, Lluís, Huerta, José María, Chirlaque, María Dolores, Overvad, Kim, Lindström, Martin, Regnér, Sara, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Fagherazzi, Guy, Katzke, Verena A, Boeing, Heiner, Peppa, Eleni, Trichopoulou, Antonia, Valanou, Elissavet, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, van Gils, Carla, Vermeulen, Roel C H, Skeie, Guri, Braaten, Tonje, Weiderpass, Elisabete, Merino, Susana, Sánchez, María José, Larrañaga, Nerea, Ardanaz, Eva, Sund, Malin, Khaw, Kay-Tee, Key, Timothy J, Jenab, Mazda, Naudin, Sabine, Murphy, Neil, Aune, Dagfinn, Ward, Heather, Riboli, Elio, Bueno-de-Mesquita, Bas, Navarro, Carmen, Duell, Eric J, Cirera, Lluís, Huerta, José María, Chirlaque, María Dolores, Overvad, Kim, Lindström, Martin, Regnér, Sara, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Fagherazzi, Guy, Katzke, Verena A, Boeing, Heiner, Peppa, Eleni, Trichopoulou, Antonia, Valanou, Elissavet, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, van Gils, Carla, Vermeulen, Roel C H, Skeie, Guri, Braaten, Tonje, Weiderpass, Elisabete, Merino, Susana, Sánchez, María José, Larrañaga, Nerea, Ardanaz, Eva, Sund, Malin, Khaw, Kay-Tee, Key, Timothy J, Jenab, Mazda, Naudin, Sabine, Murphy, Neil, Aune, Dagfinn, Ward, Heather, Riboli, Elio, Bueno-de-Mesquita, Bas, Navarro, Carmen, and Duell, Eric J
Published: 2019

13. Reproductive and lifestyle factors and circulating sRANKL and OPG concentrations in women : Results from the EPIC cohort

Author: Sarink, Danja, Yang, Jiaxi, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Fournier, Agnes, Kvaskoff, Marina, Romana Mancini, Francesca, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Agnoli, Claudia, Sacerdote, Carlotta, Masala, Giovanna, Mattiello, Amalia, Tunino, Rosario, van Gils, Carla H, Skeie, Guri, Gram, Inger T, Weiderpass, Elisabete, Lujan-Barroso, Leila, Petrova, Dafina, Santiuste, Carmen, Quirós, J Ramón, Barricarte, Aurelio, Amiano, Pilar, Travis, Ruth C, Gunter, Marc J, Dossus, Laure, Christakoudi, Sofia, Kaaks, Rudolf, Fortner, Renée T, Sarink, Danja, Yang, Jiaxi, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Fournier, Agnes, Kvaskoff, Marina, Romana Mancini, Francesca, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Agnoli, Claudia, Sacerdote, Carlotta, Masala, Giovanna, Mattiello, Amalia, Tunino, Rosario, van Gils, Carla H, Skeie, Guri, Gram, Inger T, Weiderpass, Elisabete, Lujan-Barroso, Leila, Petrova, Dafina, Santiuste, Carmen, Quirós, J Ramón, Barricarte, Aurelio, Amiano, Pilar, Travis, Ruth C, Gunter, Marc J, Dossus, Laure, Christakoudi, Sofia, Kaaks, Rudolf, and Fortner, Renée T
Published: 2019

14. Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study

Author: Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Planetary Health & Exposoom, Public Health Practice, MS MDL 1, Cirera, Lluís, Huerta, José María, Chirlaque, María Dolores, Overvad, Kim, Lindström, Martin, Regnér, Sara, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Fagherazzi, Guy, Katzke, Verena A, Boeing, Heiner, Peppa, Eleni, Trichopoulou, Antonia, Valanou, Elissavet, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, van Gils, Carla, Vermeulen, Roel C H, Skeie, Guri, Braaten, Tonje, Weiderpass, Elisabete, Merino, Susana, Sánchez, María José, Larrañaga, Nerea, Ardanaz, Eva, Sund, Malin, Khaw, Kay-Tee, Key, Timothy J, Jenab, Mazda, Naudin, Sabine, Murphy, Neil, Aune, Dagfinn, Ward, Heather, Riboli, Elio, Bueno-de-Mesquita, Bas, Navarro, Carmen, Duell, Eric J, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Planetary Health & Exposoom, Public Health Practice, MS MDL 1, Cirera, Lluís, Huerta, José María, Chirlaque, María Dolores, Overvad, Kim, Lindström, Martin, Regnér, Sara, Tjønneland, Anne, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Fagherazzi, Guy, Katzke, Verena A, Boeing, Heiner, Peppa, Eleni, Trichopoulou, Antonia, Valanou, Elissavet, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, van Gils, Carla, Vermeulen, Roel C H, Skeie, Guri, Braaten, Tonje, Weiderpass, Elisabete, Merino, Susana, Sánchez, María José, Larrañaga, Nerea, Ardanaz, Eva, Sund, Malin, Khaw, Kay-Tee, Key, Timothy J, Jenab, Mazda, Naudin, Sabine, Murphy, Neil, Aune, Dagfinn, Ward, Heather, Riboli, Elio, Bueno-de-Mesquita, Bas, Navarro, Carmen, and Duell, Eric J
Published: 2019

15. Reproductive and lifestyle factors and circulating sRANKL and OPG concentrations in women: Results from the EPIC cohort

Author: Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Yang, Jiaxi, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Fournier, Agnes, Kvaskoff, Marina, Romana Mancini, Francesca, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Agnoli, Claudia, Sacerdote, Carlotta, Masala, Giovanna, Mattiello, Amalia, Tunino, Rosario, van Gils, Carla H, Skeie, Guri, Gram, Inger T, Weiderpass, Elisabete, Lujan-Barroso, Leila, Petrova, Dafina, Santiuste, Carmen, Quirós, J Ramón, Barricarte, Aurelio, Amiano, Pilar, Travis, Ruth C, Gunter, Marc J, Dossus, Laure, Christakoudi, Sofia, Kaaks, Rudolf, Fortner, Renée T, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Yang, Jiaxi, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Fournier, Agnes, Kvaskoff, Marina, Romana Mancini, Francesca, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Agnoli, Claudia, Sacerdote, Carlotta, Masala, Giovanna, Mattiello, Amalia, Tunino, Rosario, van Gils, Carla H, Skeie, Guri, Gram, Inger T, Weiderpass, Elisabete, Lujan-Barroso, Leila, Petrova, Dafina, Santiuste, Carmen, Quirós, J Ramón, Barricarte, Aurelio, Amiano, Pilar, Travis, Ruth C, Gunter, Marc J, Dossus, Laure, Christakoudi, Sofia, Kaaks, Rudolf, and Fortner, Renée T
Published: 2019

16. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author: Duarte Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. B. As, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolores, Dorronsoro, Miren, Quirós, J. Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, Jenab, Mazda, PANICO, SALVATORE, Duarte Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno de Mesquita, H. B. A, Peeters, Petra H, Hjartåker, Anette, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolore, Dorronsoro, Miren, Quirós, J. Ramón, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Kla, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C, Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Gunter, Marc, Lu, Yunxia, and Jenab, Mazda
Subjects: Male, Cancer Research, European populations, Risk Factors, Surveys and Questionnaires, Surveys and Questionnaire, Prospective Studies, INDEX, Incidence, Liver Neoplasms, hepatocellular carcinoma, Middle Aged, CANCER, NUTRITIONAL EPIDEMIOLOGY, MEDITERRANEAN DIET, Europe, Nutritional Statu, Oncology, Liver Neoplasm, dietary fat, Female, Case-Control Studie, Life Sciences & Biomedicine, Human, Adult, Risk, Carcinoma, Hepatocellular, cohort study, dietary fats, Aged, Case-Control Studies, Diet, Dietary Fats, Feeding Behavior, Humans, Life Style, Nutritional Status, Young Adult, FISH, INFLAMMATION, LIVER-DISEASE, Oncology & Carcinogenesis, METAANALYSIS, Science & Technology, Risk Factor, Carcinoma, Hepatocellular, ACIDS, digestive system diseases, Prospective Studie, Food Habit, RISK-FACTORS, European population, Food Habits, 1112 Oncology And Carcinogenesis
Abstract: The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 122). In multivariable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk. What's new? The rise of hepatocellular carcinoma (HCC) incidence in high- and middle-income countries, where relatively high-fat diets are common, suggests a possible etiological role for dietary fat. In the present study, potential associations between HCC and total fat intake, intake of fat subtypes and intake of fat from different sources were explored with data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Total fat intake, where monounsaturated fats predominated, was inversely associated with HCC risk. By contrast, no risk associations were detected for polyunsaturated or saturated fat intake or fat source.
Published: 2015
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17. Coffee and Tea Consumption and the Contribution of Their Added Ingredients to Total Energy and Nutrient Intakes in 10 European Countries: Benchmark Data from the Late 1990s

Author: Landais, Edwige, primary, Moskal, Aurélie, additional, Mullee, Amy, additional, Nicolas, Geneviève, additional, Gunter, Marc, additional, Huybrechts, Inge, additional, Overvad, Kim, additional, Roswall, Nina, additional, Affret, Aurélie, additional, Fagherazzi, Guy, additional, Mahamat-Saleh, Yahya, additional, Katzke, Verena, additional, Kühn, Tilman, additional, La Vecchia, Carlo, additional, Trichopoulou, Antonia, additional, Valanou, Elissavet, additional, Saieva, Calogero, additional, Santucci de Magistris, Maria, additional, Sieri, Sabina, additional, Braaten, Tonje, additional, Skeie, Guri, additional, Weiderpass, Elisabete, additional, Ardanaz, Eva, additional, Chirlaque, Maria-Dolores, additional, Garcia, Jose, additional, Jakszyn, Paula, additional, Rodríguez-Barranco, Miguel, additional, Brunkwall, Louise, additional, Huseinovic, Ena, additional, Nilsson, Lena, additional, Wallström, Peter, additional, Bueno-de-Mesquita, Bas, additional, Peeters, Petra, additional, Aune, Dagfinn, additional, Key, Tim, additional, Lentjes, Marleen, additional, Riboli, Elio, additional, Slimani, Nadia, additional, and Freisling, Heinz, additional
Published: 2018
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18. Coffee and Tea Consumption and the Contribution of Their Added Ingredients to Total Energy and Nutrient Intakes in 10 European Countries : Benchmark Data from the Late 1990s

Author: Landais, Edwige, Moskal, Aurelie, Mullee, Amy, Nicolas, Genevieve, Gunter, Marc J., Huybrechts, Inge, Overvad, Kim, Roswall, Nina, Affret, Aurelie, Fagherazzi, Guy, Mahamat-Saleh, Yahya, Katzke, Verena, Kuehn, Tilman, La Vecchia, Carlo, Trichopoulou, Antonia, Valanou, Elissavet, Saieva, Calogero, de Magistris, Maria Santucci, Sieri, Sabina, Braaten, Tonje, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Chirlaque, Maria-Dolores, Garcia, Jose Ramon, Jakszyn, Paula, Rodriguez-Barranco, Miguel, Brunkwall, Louise, Huseinovic, Ena, Nilsson, Lena, Wallström, Peter, Bueno-de-Mesquita, Bas, Peeters, Petra H., Aune, Dagfinn, Key, Tim, Lentjes, Marleen, Riboli, Elio, Slimani, Nadia, Freisling, Heinz, Landais, Edwige, Moskal, Aurelie, Mullee, Amy, Nicolas, Genevieve, Gunter, Marc J., Huybrechts, Inge, Overvad, Kim, Roswall, Nina, Affret, Aurelie, Fagherazzi, Guy, Mahamat-Saleh, Yahya, Katzke, Verena, Kuehn, Tilman, La Vecchia, Carlo, Trichopoulou, Antonia, Valanou, Elissavet, Saieva, Calogero, de Magistris, Maria Santucci, Sieri, Sabina, Braaten, Tonje, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Chirlaque, Maria-Dolores, Garcia, Jose Ramon, Jakszyn, Paula, Rodriguez-Barranco, Miguel, Brunkwall, Louise, Huseinovic, Ena, Nilsson, Lena, Wallström, Peter, Bueno-de-Mesquita, Bas, Peeters, Petra H., Aune, Dagfinn, Key, Tim, Lentjes, Marleen, Riboli, Elio, Slimani, Nadia, and Freisling, Heinz
Abstract: Background: Coffee and tea are among the most commonly consumed nonalcoholic beverages worldwide, but methodological differences in assessing intake often hamper comparisons across populations. We aimed to (i) describe coffee and tea intakes and (ii) assess their contribution to intakes of selected nutrients in adults across 10 European countries. Method: Between 1995 and 2000, a standardized 24-h dietary recall was conducted among 36,018 men and women from 27 European Prospective Investigation into Cancer and Nutrition (EPIC) study centres. Adjusted arithmetic means of intakes were estimated in grams (=volume) per day by sex and centre. Means of intake across centres were compared by sociodemographic characteristics and lifestyle factors. Results: In women, the mean daily intake of coffee ranged from 94 g/day (similar to 0.6 cups) in Greece to 781 g/day (similar to 4.4 cups) in Aarhus (Denmark), and tea from 14 g/day (similar to 0.1 cups) in Navarra (Spain) to 788 g/day (similar to 4.3 cups) in the UK general population. Similar geographical patterns for mean daily intakes of both coffee and tea were observed in men. Current smokers as compared with those who reported never smoking tended to drink on average up to 500 g/day more coffee and tea combined, but with substantial variation across centres. Other individuals' characteristics such as educational attainment or age were less predictive. In all centres, coffee and tea contributed to less than 10% of the energy intake. The greatest contribution to total sugar intakes was observed in Southern European centres (up to similar to 20%). Conclusion: Coffee and tea intake and their contribution to energy and sugar intake differed greatly among European adults. Variation in consumption was mostly driven by geographical region.
Published: 2018
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19. Coffee and tea consumption and the contribution of their added ingredients to total energy and nutrient intakes in 10 European countries: Benchmark data from the late 1990s

Author: MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Landais, Edwige, Moskal, Aurélie, Mullee, Amy, Nicolas, Geneviève, Gunter, Marc J., Huybrechts, Inge, Overvad, Kim, Roswall, Nina, Affret, Aurélie, Fagherazzi, Guy, Mahamat-Saleh, Yahya, Katzke, Verena, Kühn, Tilman, la Vecchia, Carlo, Trichopoulou, Antonia, Valanou, Elissavet, Saieva, Calogero, de Magistris, Maria Santucci, Sieri, Sabina, Braaten, Tonje, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Chirlaque, Maria Dolores, Garcia, Jose Ramon, Jakszyn, Paula, Rodríguez-Barranco, Miguel, Brunkwall, Louise, Huseinovic, Ena, Nilsson, Lena, Wallström, Peter, Bueno-De-Mesquita, Bas, Peeters, Petra H., Aune, Dagfinn, Key, Tim, Lentjes, Marleen, Riboli, Elio, Slimani, Nadia, Freisling, Heinz, MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Landais, Edwige, Moskal, Aurélie, Mullee, Amy, Nicolas, Geneviève, Gunter, Marc J., Huybrechts, Inge, Overvad, Kim, Roswall, Nina, Affret, Aurélie, Fagherazzi, Guy, Mahamat-Saleh, Yahya, Katzke, Verena, Kühn, Tilman, la Vecchia, Carlo, Trichopoulou, Antonia, Valanou, Elissavet, Saieva, Calogero, de Magistris, Maria Santucci, Sieri, Sabina, Braaten, Tonje, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Chirlaque, Maria Dolores, Garcia, Jose Ramon, Jakszyn, Paula, Rodríguez-Barranco, Miguel, Brunkwall, Louise, Huseinovic, Ena, Nilsson, Lena, Wallström, Peter, Bueno-De-Mesquita, Bas, Peeters, Petra H., Aune, Dagfinn, Key, Tim, Lentjes, Marleen, Riboli, Elio, Slimani, Nadia, and Freisling, Heinz
Published: 2018

20. The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Sawada, Norie Wark, Petra A. Merritt, Melissa A. Tsugane, Shoichiro Ward, Heather A. Rinaldi, Sabina Weiderpass, Elisabete Dartois, Laureen His, Mathilde Boutron-Ruault, Marie-Christine Turzanski-Fortner, Renee Kaaks, Rudolf and Overvad, Kim Redondo, Maria-Luisa Travier, Noemie and Molina-Portillo, Elena Dorronsoro, Miren Cirera, Lluis and Ardanaz, Eva Perez-Cornago, Aurora Trichopoulou, Antonia and Lagiou, Pagona Valanou, Elissavet Masala, Giovanna Pala, Valeria Peeters, Petra H. M. van der Schouw, Yvonne T. and Melander, Olle Manjer, Jonas da Silva, Marisa Skeie, Guri and Tjonneland, Anne Olsen, Anja Gunter, Marc J. Riboli, Elio Cross, Amanda J.
Abstract: Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in similar to 253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: HRQ5 vs. Q1 = 1.11, 95% CI = 1.00-1.24; women: HRQ5 vs. Q1 = 1.17, 95% CI = 1.07-1.28). In contrast, height was inversely associated with circulatory disease mortality (men: HRQ5 vs. Q1 = 0.63, 95% CI = 0.56 - 0.71; women: HRQ5 vs. Q1 = 0.81, 95% CI = 0.70 - 0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: HRQ5 vs. Q1 = 0.64, 95% CI = 0.55 - 0.75; women: HRQ5 vs. Q1 = 0.60, 95% CI = 0.49 - 0.74) and respiratory disease mortality (men: HRQ5 vs. Q1 = 0.45, 95% CI = 0.28 - 0.71; women: HRQ5 vs. Q1 = 0.60, 95% CI = 0.40 - 0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.
Published: 2017

21. The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author: Sawada, Norie, primary, Wark, Petra A., additional, Merritt, Melissa A., additional, Tsugane, Shoichiro, additional, Ward, Heather A., additional, Rinaldi, Sabina, additional, Weiderpass, Elisabete, additional, Dartois, Laureen, additional, His, Mathilde, additional, Boutron-Ruault, Marie-Christine, additional, Turzanski-Fortner, Renée, additional, Kaaks, Rudolf, additional, Overvad, Kim, additional, Redondo, María-Luisa, additional, Travier, Noemie, additional, Molina-Portillo, Elena, additional, Dorronsoro, Miren, additional, Cirera, Lluis, additional, Ardanaz, Eva, additional, Perez-Cornago, Aurora, additional, Trichopoulou, Antonia, additional, Lagiou, Pagona, additional, Valanou, Elissavet, additional, Masala, Giovanna, additional, Pala, Valeria, additional, HM Peeters, Petra, additional, T. van der Schouw, Yvonne, additional, Melander, Olle, additional, Manjer, Jonas, additional, da Silva, Marisa, additional, Skeie, Guri, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, J. Gunter, Marc, additional, Riboli, Elio, additional, and J. Cross, Amanda, additional
Published: 2017
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22. The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC)

Author: Sawada, Norie, Wark, Petra A., Merritt, Melissa A., Tsugane, Shoichiro, Ward, Heather A., Rinaldi, Sabina, Weiderpass, Elisabete, Dartois, Laureen, His, Mathilde, Boutron-Ruault, Marie Christine, Turzanski-Fortner, Renée, Kaaks, Rudolf, Overvad, Kim, Redondo, María Luisa, Travier, Noemie, Molina-Portillo, Elena, Dorronsoro, Miren, Cirera, Lluis, Ardanaz, Eva, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Valanou, Elissavet, Masala, Giovanna, Pala, Valeria, Peeters, Petra H M, Van Der Schouw, Yvonne T., Melander, Olle, Manjer, Jonas, Silva, Marisa Da, Skeie, Guri, Tjønneland, Anne, Olsen, Anja, Gunter, Marc J., Riboli, Elio, Cross, Amanda J., Sawada, Norie, Wark, Petra A., Merritt, Melissa A., Tsugane, Shoichiro, Ward, Heather A., Rinaldi, Sabina, Weiderpass, Elisabete, Dartois, Laureen, His, Mathilde, Boutron-Ruault, Marie Christine, Turzanski-Fortner, Renée, Kaaks, Rudolf, Overvad, Kim, Redondo, María Luisa, Travier, Noemie, Molina-Portillo, Elena, Dorronsoro, Miren, Cirera, Lluis, Ardanaz, Eva, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Valanou, Elissavet, Masala, Giovanna, Pala, Valeria, Peeters, Petra H M, Van Der Schouw, Yvonne T., Melander, Olle, Manjer, Jonas, Silva, Marisa Da, Skeie, Guri, Tjønneland, Anne, Olsen, Anja, Gunter, Marc J., Riboli, Elio, and Cross, Amanda J.
Published: 2017

23. Physical activity, mediating factors and risk of colon cancer: Insights into adiposity and circulating biomarkers from the EPIC cohort

Author: UMC Utrecht, MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael F., Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobias, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C., Tjønneland, Anne, Bouton-Ruault, Marie Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, van Vulpen, Jonna, Borch, Kristin Benjaminsen, Oyeyemi, Sunday Oluwafemi, Quirós, José Ramón, Bonet, Catalina, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J., Khaw, Kay Tee, Wareham, Nicholas J., Assi, Nada, Ward, Heather A., Aune, Dagfinn, Riboli, Elio, Boeing, Heiner, UMC Utrecht, MS MDL 1, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Epi Kanker Team B, Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael F., Bueno-de-Mesquita, Bas, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobias, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C., Tjønneland, Anne, Bouton-Ruault, Marie Christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, van Vulpen, Jonna, Borch, Kristin Benjaminsen, Oyeyemi, Sunday Oluwafemi, Quirós, José Ramón, Bonet, Catalina, Sánchez, Mariá José, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J., Khaw, Kay Tee, Wareham, Nicholas J., Assi, Nada, Ward, Heather A., Aune, Dagfinn, Riboli, Elio, and Boeing, Heiner
Published: 2017

24. The association between adult attained height and sitting height with mortality in the European prospective investigation into cancer and nutrition (EPIC)

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Sawada, Norie, Wark, Petra A., Merritt, Melissa A., Tsugane, Shoichiro, Ward, Heather A., Rinaldi, Sabina, Weiderpass, Elisabete, Dartois, Laureen, His, Mathilde, Boutron-Ruault, Marie Christine, Turzanski-Fortner, Renée, Kaaks, Rudolf, Overvad, Kim, Redondo, María Luisa, Travier, Noemie, Molina-Portillo, Elena, Dorronsoro, Miren, Cirera, Lluis, Ardanaz, Eva, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Valanou, Elissavet, Masala, Giovanna, Pala, Valeria, Peeters, Petra H M, Van Der Schouw, Yvonne T., Melander, Olle, Manjer, Jonas, Silva, Marisa Da, Skeie, Guri, Tjønneland, Anne, Olsen, Anja, Gunter, Marc J., Riboli, Elio, Cross, Amanda J., Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Cardiovasculaire Epidemiologie, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Sawada, Norie, Wark, Petra A., Merritt, Melissa A., Tsugane, Shoichiro, Ward, Heather A., Rinaldi, Sabina, Weiderpass, Elisabete, Dartois, Laureen, His, Mathilde, Boutron-Ruault, Marie Christine, Turzanski-Fortner, Renée, Kaaks, Rudolf, Overvad, Kim, Redondo, María Luisa, Travier, Noemie, Molina-Portillo, Elena, Dorronsoro, Miren, Cirera, Lluis, Ardanaz, Eva, Perez-Cornago, Aurora, Trichopoulou, Antonia, Lagiou, Pagona, Valanou, Elissavet, Masala, Giovanna, Pala, Valeria, Peeters, Petra H M, Van Der Schouw, Yvonne T., Melander, Olle, Manjer, Jonas, Silva, Marisa Da, Skeie, Guri, Tjønneland, Anne, Olsen, Anja, Gunter, Marc J., Riboli, Elio, and Cross, Amanda J.
Published: 2017

25. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author: Duarte-Salles, Talita Fedirko, Veronika Stepien, Magdalena and Aleksandrova, Krasimira Bamia, Christina Lagiou, Pagona and Laursen, Anne Sofie Dam Hansen, Louise Overvad, Kim and Tjonneland, Anne Boutron-Ruault, Marie-Christine Fagherazzi, Guy and His, Mathilde Boeing, Heiner Katzke, Verena Kuehn, Tilman Trichopoulou, Antonia Valanou, Elissavet Kritikou, Maria Masala, Giovanna Panico, Salvatore Sieri, Sabina and Ricceri, Fulvio Tumino, Rosario Bueno-de-Mesquita, H. B. (As) and Peeters, Petra H. Hjartaker, Anette Skeie, Guri and Weiderpass, Elisabete Ardanaz, Eva Bonet, Catalina and Chirlaque, Maria-Dolores Dorronsoro, Miren Quiros, J. Ramon and Johansson, Ingegerd Ohlsson, Bodil Sjoberg, Klas Wennberg, Maria Khaw, Kay-Tee Travis, Ruth C. Wareham, Nick and Ferrari, Pietro Freisling, Heinz Romieu, Isabelle Cross, Amanda J. Gunter, Marc Lu, Yunxia Jenab, Mazda
Subjects: digestive system diseases
Abstract: The role of amount and type of dietary fat consumption in the etiology of hepatocellular carcinoma (HCC) is poorly understood, despite suggestive biological plausibility. The associations of total fat, fat subtypes and fat sources with HCC incidence were investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which includes 191 incident HCC cases diagnosed between 1992 and 2010. Diet was assessed by country-specific, validated dietary questionnaires. A single 24-hr diet recall from a cohort subsample was used for measurement error calibration. Hazard ratios (HR) and 95% confidence intervals (95% CI) were estimated from Cox proportional hazard models. Hepatitis B and C viruses (HBV/HCV) status and biomarkers of liver function were assessed separately in a nested case-control subset with available blood samples (HCC = 22). In multi-variable calibrated models, there was a statistically significant inverse association between total fat intake and risk of HCC (per 10 g/day, HR = 0.80, 95% CI: 0.65-0.99), which was mainly driven by monounsaturated fats (per 5 g/day, HR = 0.71, 95% CI: 0.55-0.92) rather than polyunsaturated fats (per 5 g/day, HR = 0.92, 95% CI: 0.68-1.25). There was no association between saturated fats (HR = 1.08, 95% CI: 0.88-1.34) and HCC risk. The ratio of polyunsaturated/monounsaturated fats to saturated fats was not significantly associated with HCC risk (per 0.2 point, HR = 0.86, 95% CI: 0.73-1.01). Restriction of analyses to HBV/HCV free participants or adjustment for liver function did not substantially alter the findings. In this large prospective European cohort, higher consumption of monounsaturated fats is associated with lower HCC risk.
Published: 2015

26. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A., Hemon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjonneland, Anne, Kyro, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Engeset, Dagrun, Skeie, Guri, Hjartaker, Anette, Menendez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Maria Huerta, Jose, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J., Khaw, Kay-Thee, Wareham, Nicholas J., Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, Scalbert, Augustin, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Zamora-Ros, Raul, Knaze, Viktoria, Rothwell, Joseph A., Hemon, Bertrand, Moskal, Aurelie, Overvad, Kim, Tjonneland, Anne, Kyro, Cecilie, Fagherazzi, Guy, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Katzke, Verena, Kuehn, Tilman, Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Valanou, Elissavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Ricceri, Fulvio, Tumino, Rosario, de Magistris, Maria Santucci, Peeters, Petra H. M., Bueno-de-Mesquita, H. Bas, Engeset, Dagrun, Skeie, Guri, Hjartaker, Anette, Menendez, Virginia, Agudo, Antonio, Molina-Montes, Esther, Maria Huerta, Jose, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, Nilsson, Lena Maria, Landberg, Rikard, Key, Timothy J., Khaw, Kay-Thee, Wareham, Nicholas J., Lu, Yunxia, Slimani, Nadia, Romieu, Isabelle, Riboli, Elio, and Scalbert, Augustin
Published: 2016

27. Cross-Sectional Associations of Objectively Measured Physical Activity, Cardiorespiratory Fitness and Anthropometry in European Adults

Author: Wientzek, Angelika Tormo Diaz, Maria-Jose Huerta Castano, Jose Maria Amiano, Pilar Arriola, Larraitz Overvad, Kim and Ostergaard, Jane Nautrup Charles, Marie-Aline Fagherazzi, Guy and Palli, Domenico Bendinelli, Benedetta Skeie, Guri Borch, Kristin Benjaminsen Wendel-Vos, Wanda de Hollander, Ellen and May, Anne M. den Ouden, Marjolein E. M. Trichopoulou, Antonia and Valanou, Elissavet Soederberg, Stefan Franks, Paul W. and Brage, Soren Vigl, Matthaus Boeing, Heiner Ekelund, Ulf
Subjects: human activities, hormones, hormone substitutes, and hormone antagonists
Abstract: Objective: To quantify the independent associations between objectively measured physical activity (PA), cardiorespiratory fitness (CRF), and anthropometry in European men and women. Methods: 2,056 volunteers from 12 centers across Europe were fitted with a heart rate and movement sensor at 2 visits 4 months apart for a total of 8 days. CRF (ml/kg/min) was estimated from an 8 minute ramped step test. A cross-sectional analysis of the independent associations between objectively measured PA (m/s(2)/d), moderate and vigorous physical activity (MVPA) (% time/d), sedentary time (% time/d), CRF, and anthropometry using sex stratified multiple linear regression was performed. Results: In mutually adjusted models, CRF, PA, and MVPA were inversely associated with all anthropometric markers in women. In men, CRF, PA, and MVPA were inversely associated with BMI, whereas only CRF was significantly associated with the other anthropometric markers. Sedentary time was positively associated with all anthropometric markers, however, after adjustment for CRF significant in women only. Conclusion: CRF, PA, MVPA, and sedentary time are differently associated with anthropometric markers in men and women. CRF appears to attenuate associations between PA, MVPA, and sedentary time. These observations may have implications for prevention of obesity.
Published: 2014

28. Meat and heme iron intake and esophageal adenocarcinoma the European Prospective investigation into Cancer and Nutrition study

Author: Jakszyn, Paula, Luján-Barroso, Leila, Agudo, Antonio, Bueno-de-Mesquita, H Bas, Molina, Esther, Sánchez, M José, Fonseca-Nunes, Ana, Siersema, Peter D, Matiello, Amalia, Tumino, Rosario, Saieva, Calogero, Pala, Valeria, Vineis, Paolo, Boutron-Ruault, Marie-Christine, Racine, Antoine, Bastide, Nadie, Travis, Ruth C, Khaw, Kay-Tee, Riboli, Elio, Murphy, Neil, Vergnaud, Anne-Claire, Trichopoulou, Antonia, Valanou, Elissavet, Oikonomidou, Despina, Weiderpass, Elisabete, Skeie, Guri, Johansen, Dorthe, Lindkvist, Björn, Johansson, Mattias, Duarte-Salles, Talita, Freisling, Heinz, Barricarte, Aurelio, Huerta, Jose M, Amiano, Pilar, Tjonneland, Anne, Overvad, Kim, Kuehn, Tilman, Grote, Verena, Boeing, Heiner, Peeters, Petra Hm, and González, Carlos A
Subjects: food and beverages
Abstract: Although recent studies suggest that high intakes of meat and heme iron are risk factors for several types of cancer, studies in relation to esophageal adenocarcinoma (EAC) are scarce. Previous results in the European Prospective Investigation into Cancer and Nutrition (EPIC) based on a relatively small number of cases suggested a positive association between processed meat and EAC. In this study we investigate the association between intake of different types of meats as well as heme iron intake, and EAC risk in a larger number of cases from EPIC. The study included 481,419 individuals and 137 incident cases of EAC that occurred during an average of 11 years of follow-up. Dietary intake of meat (unprocessed/processed red and white meat) was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat. After adjusting for relevant confounders we observed a statistically significant positive association of EAC risk with heme iron and processed meat intake, with HR: 1.67, 95% CI: 1.05-2.68 and HR: 2.27, 95% CI:1.33-3.89 respectively for comparison of the highest vs. lowest tertile of intake Our results suggest a potential association between higher intakes of processed meat and heme iron and risk of EAC. © 2013 Wiley Periodicals, Inc.
Published: 2013
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29. Meat and heme iron intake and esophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study

Author: Jakszyn, Paula Lujan-Barroso, Leila Agudo, Antonio and Bueno-de-Mesquita, H. Bas Molina, Esther Sanchez, Ma Jose and Fonseca-Nunes, Ana Siersema, Peter D. Matiello, Amalia and Tumino, Rosario Saieva, Calogero Pala, Valeria Vineis, Paolo and Boutron-Ruault, Marie-Christine Racine, Antoine Bastide, Nadie Travis, Ruth C. Khaw, Kay-Tee Riboli, Elio Murphy, Neil Vergnaud, Anne-Claire Trichopoulou, Antonia Valanou, Elissavet Oikonomidou, EDespina Weiderpass, Elisabete Skeie, Guri Johansen, Dorthe Lindkvist, Bjorn Johansson, Mattias and Duarte-Salles, Talita Freisling, Heinz Barricarte, Aurelio and Huerta, Jose Ma Amiano, Pilar Tjonneland, Anne Overvad, Kim Kuehn, Tilman Grote, Verena Boeing, Heiner Peeters, Petra H. M. Gonzalez, Carlos A.
Subjects: food and beverages
Abstract: Although recent studies suggest that high intakes of meat and heme iron are risk factors for several types of cancer, studies in relation to esophageal adenocarcinoma (EAC) are scarce. Previous results in the European Prospective Investigation into Cancer and Nutrition (EPIC) based on a relatively small number of cases suggested a positive association between processed meat and EAC. In this study, we investigate the association between intake of different types of meats and heme iron intake and EAC risk in a larger number of cases from EPIC. The study included 481,419 individuals and 137 incident cases of EAC that occurred during an average of 11 years of follow-up. Dietary intake of meat (unprocessed/processed red and white meat) was assessed by validated center-specific questionnaires. Heme iron was calculated as a type-specific percentage of the total iron content in meat. After adjusting for relevant confounders, we observed a statistically significant positive association of EAC risk with heme iron and processed meat intake, with HR: 1.67, 95% CI: 1.05-2.68 and HR: 2.27, 95% CI:1.33-3.89, respectively, for comparison of the highest vs. lowest tertile of intake. Our results suggest a potential association between higher intakes of processed meat and heme iron and risk of EAC.
Published: 2013

30. Body size and risk of differentiated thyroid carcinomas: Findings from the EPIC study

Author: Rinaldi, Sabina Lise, Mauro Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine Guillas, Gwenaelle Overvad, Kim and Tjonneland, Anne Halkjaer, Jytte Lukanova, Annekatrin and Kaaks, Rudolf Bergmann, Manuela M. Boeing, Heiner and Trichopoulou, Antonia Zylis, Dimosthenis Valanou, Elissavet and Palli, Domenico Agnoli, Claudia Tumino, Rosario Polidoro, Silvia Mattiello, Amalia Bueno-de-Mesquita, H. Bas Peeters, Petra H. Weiderpass, Elisabete Lund, Eiliv Skeie, Guri and Rodriguez, Laudina Travier, Noemie Sanchez, Maria-Jose and Amiano, Pilar Huerta, Jose-Maria Ardanaz, Eva Rasmuson, Torgny Hallmans, Goeran Almquist, Martin Manjer, Jonas and Tsilidis, Konstantinos K. Allen, Naomi E. Khaw, Kay-Tee and Wareham, Nick Byrnes, Graham Romieu, Isabelle Riboli, Elio and Franceschi, Silvia
Abstract: Results from case-control and prospective studies suggest a moderate positive association between obesity and height and differentiated thyroid carcinoma (TC). Little is known on the relationship between other measures of adiposity and differentiated TC risk. Here, we present the results of a study on body size and risk of differentiated TC based on a large European prospective study (EPIC). During follow-up, 508 incident cases of differentiated TC were identified in women, and 58 in men. 78% of cases were papillary TC. Cox proportional hazard models were used to estimate hazard ratios (HRs). In women, differentiated TC risk was significantly associated with body mass index (BMI, kg/m2) (HR highest vs lowest quintile = 1.41, 95% CI: 1.031.94); height (HR = 1.61; 95% CI: 1.182.20); HR highest vs lowest tertile waist (HR = 1.34, 95% CI: 1.001.79) and waist-to-hip ratio (HR = 1.42, 95% CI: 1.051.91). The association with BMI was somewhat stronger in women below age 50. Corresponding associations for papillary TC were similar to those for all differentiated TC. In men the only body size factors significantly associated with differentiated TC were height (non linear), and leg length (HR highest vs. lowest tertile = 3.03, 95% CI: 1.307.07). Our study lends further support to the presence of a moderate positive association between differentiated TC risk and overweight and obesity in women. The risk increase among taller individuals of both sexes suggests that some genetic characteristics or early environmental exposures may also be implicated in the etiology of differentiated TC.
Published: 2012

31. Dietary fat, fat subtypes and hepatocellular carcinoma in a large European cohort

Author: MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-De-Mesquita, H. B., Peeters, Petra H., Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolores, Dorronsoro, Miren, Quirõs, J. Ramõn, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C., Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J., Gunter, Marc, Lu, Yunxia, Jenab, Mazda, MS MDL 1, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Duarte-Salles, Talita, Fedirko, Veronika, Stepien, Magdalena, Aleksandrova, Krasimira, Bamia, Christina, Lagiou, Pagona, Laursen, Anne Sofie Dam, Hansen, Louise, Overvad, Kim, Tjønneland, Anne, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, His, Mathilde, Boeing, Heiner, Katzke, Verena, Kühn, Tilman, Trichopoulou, Antonia, Valanou, Elissavet, Kritikou, Maria, Masala, Giovanna, Panico, Salvatore, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Bueno-De-Mesquita, H. B., Peeters, Petra H., Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Bonet, Catalina, Chirlaque, Maria Dolores, Dorronsoro, Miren, Quirõs, J. Ramõn, Johansson, Ingegerd, Ohlsson, Bodil, Sjöberg, Klas, Wennberg, Maria, Khaw, Kay Tee, Travis, Ruth C., Wareham, Nick, Ferrari, Pietro, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J., Gunter, Marc, Lu, Yunxia, and Jenab, Mazda
Published: 2015

32. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Zamora-Ros, Raul, primary, Knaze, Viktoria, additional, Rothwell, Joseph A., additional, Hémon, Bertrand, additional, Moskal, Aurelie, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Fagherazzi, Guy, additional, Boutron-Ruault, Marie-Christine, additional, Touillaud, Marina, additional, Katzke, Verena, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Förster, Jana, additional, Trichopoulou, Antonia, additional, Valanou, Elissavet, additional, Peppa, Eleni, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Ricceri, Fulvio, additional, Tumino, Rosario, additional, de Magistris, Maria Santucci, additional, Peeters, Petra H. M., additional, Bueno-de-Mesquita, H. Bas, additional, Engeset, Dagrun, additional, Skeie, Guri, additional, Hjartåker, Anette, additional, Menéndez, Virginia, additional, Agudo, Antonio, additional, Molina-Montes, Esther, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Sonestedt, Emily, additional, Nilsson, Lena Maria, additional, Landberg, Rikard, additional, Key, Timothy J., additional, Khaw, Kay-Thee, additional, Wareham, Nicholas J., additional, Lu, Yunxia, additional, Slimani, Nadia, additional, Romieu, Isabelle, additional, Riboli, Elio, additional, and Scalbert, Augustin, additional
Published: 2015
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33. Cross-Sectional Associations of Objectively Measured Physical Activity, Cardiorespiratory Fitness and Anthropometry in European Adults

Author: Wientzek, Angelika, Tormo Diaz, Maria-Jose, Huerta Castano, Jose Maria, Amiano, Pilar, Arriola, Larraitz, Overvad, Kim, Ostergaard, Jane Nautrup, Charles, Marie-Aline, Fagherazzi, Guy, Palli, Domenico, Bendinelli, Benedetta, Skeie, Guri, Borch, Kristin Benjaminsen, Wendel-Vos, Wanda, de Hollander, Ellen, May, Anne M., den Ouden, Marjolein E. M., Trichopoulou, Antonia, Valanou, Elissavet, Söderberg, Stefan, Franks, Paul W., Brage, Soren, Vigl, Matthaus, Boeing, Heiner, Ekelund, Ulf, Wientzek, Angelika, Tormo Diaz, Maria-Jose, Huerta Castano, Jose Maria, Amiano, Pilar, Arriola, Larraitz, Overvad, Kim, Ostergaard, Jane Nautrup, Charles, Marie-Aline, Fagherazzi, Guy, Palli, Domenico, Bendinelli, Benedetta, Skeie, Guri, Borch, Kristin Benjaminsen, Wendel-Vos, Wanda, de Hollander, Ellen, May, Anne M., den Ouden, Marjolein E. M., Trichopoulou, Antonia, Valanou, Elissavet, Söderberg, Stefan, Franks, Paul W., Brage, Soren, Vigl, Matthaus, Boeing, Heiner, and Ekelund, Ulf
Abstract: Objective: To quantify the independent associations between objectively measured physical activity (PA), cardiorespiratory fitness (CRF), and anthropometry in European men and women. Methods: 2,056 volunteers from 12 centers across Europe were fitted with a heart rate and movement sensor at 2 visits 4 months apart for a total of 8 days. CRF (ml/kg/min) was estimated from an 8 minute ramped step test. A cross-sectional analysis of the independent associations between objectively measured PA (m/s(2)/d), moderate and vigorous physical activity (MVPA) (% time/d), sedentary time (% time/d), CRF, and anthropometry using sex stratified multiple linear regression was performed. Results: In mutually adjusted models, CRF, PA, and MVPA were inversely associated with all anthropometric markers in women. In men, CRF, PA, and MVPA were inversely associated with BMI, whereas only CRF was significantly associated with the other anthropometric markers. Sedentary time was positively associated with all anthropometric markers, however, after adjustment for CRF significant in women only. Conclusion: CRF, PA, MVPA, and sedentary time are differently associated with anthropometric markers in men and women. CRF appears to attenuate associations between PA, MVPA, and sedentary time. These observations may have implications for prevention of obesity.
Published: 2014
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34. Cross‐sectional associations of objectively measured physical activity, cardiorespiratory fitness and anthropometry in European adults

Author: Wientzek, Angelika, primary, Tormo Díaz, María‐José, additional, Castaño, Jose Maria Huerta, additional, Amiano, Pilar, additional, Arriola, Larraitz, additional, Overvad, Kim, additional, Østergaard, Jane Nautrup, additional, Charles, Marie‐Aline, additional, Fagherazzi, Guy, additional, Palli, Domenico, additional, Bendinelli, Benedetta, additional, Skeie, Guri, additional, Borch, Kristin Benjaminsen, additional, Wendel‐Vos, Wanda, additional, Hollander, Ellen, additional, May, Anne M., additional, Ouden, Marjolein EM, additional, Trichopoulou, Antonia, additional, Valanou, Elissavet, additional, Söderberg, Stefan, additional, Franks, Paul W., additional, Brage, Soren, additional, Vigl, Matthäus, additional, Boeing, Heiner, additional, and Ekelund, Ulf, additional
Published: 2013
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35. Coffee and Tea Consumption and the Contribution of Their Added Ingredients to Total Energy and Nutrient Intakes in 10 European Countries: Benchmark Data from the Late 1990s

Author: Landais, Edwige, Moskal, Aurélie, Mullee, Amy, Nicolas, Geneviève, Gunter, Marc J, Huybrechts, Inge, Overvad, Kim, Roswall, Nina, Affret, Aurélie, Fagherazzi, Guy, Mahamat-Saleh, Yahya, Katzke, Verena, Kühn, Tilman, La Vecchia, Carlo, Trichopoulou, Antonia, Valanou, Elissavet, Saieva, Calogero, Santucci De Magistris, Maria, Sieri, Sabina, Braaten, Tonje, Skeie, Guri, Weiderpass, Elisabete, Ardanaz, Eva, Chirlaque, Maria-Dolores, Garcia, Jose Ramon, Jakszyn, Paula, Rodríguez-Barranco, Miguel, Brunkwall, Louise, Huseinovic, Ena, Nilsson, Lena, Wallström, Peter, Bueno-De-Mesquita, Bas, Peeters, Petra H, Aune, Dagfinn, Key, Tim, Lentjes, Marleen, Riboli, Elio, Slimani, Nadia, and Freisling, Heinz
Subjects: 2. Zero hunger, Adult, Male, 24-h dietary recall, tea, Time Factors, coffee, Smoking, Nutritional Status, Feeding Behavior, European Prospective Investigation into Cancer and Nutrition, Middle Aged, Nutrition Surveys, Recommended Dietary Allowances, 3. Good health, Europe, Benchmarking, Socioeconomic Factors, Humans, Female, Prospective Studies, Energy Intake, Life Style, Nutritive Value, Aged
Abstract: BACKGROUND: Coffee and tea are among the most commonly consumed nonalcoholic beverages worldwide, but methodological differences in assessing intake often hamper comparisons across populations. We aimed to (i) describe coffee and tea intakes and (ii) assess their contribution to intakes of selected nutrients in adults across 10 European countries. METHOD: Between 1995 and 2000, a standardized 24-h dietary recall was conducted among 36,018 men and women from 27 European Prospective Investigation into Cancer and Nutrition (EPIC) study centres. Adjusted arithmetic means of intakes were estimated in grams (=volume) per day by sex and centre. Means of intake across centres were compared by sociodemographic characteristics and lifestyle factors. RESULTS: In women, the mean daily intake of coffee ranged from 94 g/day (~0.6 cups) in Greece to 781 g/day (~4.4 cups) in Aarhus (Denmark), and tea from 14 g/day (~0.1 cups) in Navarra (Spain) to 788 g/day (~4.3 cups) in the UK general population. Similar geographical patterns for mean daily intakes of both coffee and tea were observed in men. Current smokers as compared with those who reported never smoking tended to drink on average up to 500 g/day more coffee and tea combined, but with substantial variation across centres. Other individuals' characteristics such as educational attainment or age were less predictive. In all centres, coffee and tea contributed to less than 10% of the energy intake. The greatest contribution to total sugar intakes was observed in Southern European centres (up to ~20%). CONCLUSION: Coffee and tea intake and their contribution to energy and sugar intake differed greatly among European adults. Variation in consumption was mostly driven by geographical region.

36. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Zamora-Ros, Raul, Cayssials, Valerie, Jenab, Mazda, Rothwell, Joseph A, Fedirko, Veronika, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elissavet, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Weiderpass, Elisabete, Lukic, Marko, Sandanger, Torkjel M, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Navarro, Carmen, Ardanaz, Eva, Sonestedt, Emily, Ohlsson, Bodil, Nilsson, Lena Maria, Rutegård, Martin, Bueno-De-Mesquita, Bas, Peeters, Petra H, Khaw, Kay-Thee, Wareham, Nicholas J, Bradbury, Kathryn, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Vineis, Paolo, and Scalbert, Augustin
Subjects: Adult, Male, Tea, food and beverages, Polyphenols, Prospective cohort, Middle Aged, Colorectal cancer, Coffee, 3. Good health, Diet, Cohort Studies, Europe, Nutrition Assessment, Surveys and Questionnaires, Intake, Humans, Female, Prospective Studies, EPIC, Colorectal Neoplasms, Aged, Follow-Up Studies
Abstract: Polyphenols may play a chemopreventive role in colorectal cancer (CRC); however, epidemiological evidence supporting a role for intake of individual polyphenol classes, other than flavonoids is insufficient. We evaluated the association between dietary intakes of total and individual classes and subclasses of polyphenols and CRC risk and its main subsites, colon and rectum, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The cohort included 476,160 men and women from 10 European countries. During a mean follow-up of 14 years, there were 5991 incident CRC cases, of which 3897 were in the colon and 2094 were in the rectum. Polyphenol intake was estimated using validated centre/country specific dietary questionnaires and the Phenol-Explorer database. In multivariable-adjusted Cox regression models, a doubling in total dietary polyphenol intake was not associated with CRC risk in women (HRlog2 = 1.06, 95% CI 0.99-1.14) or in men (HRlog2 = 0.97, 95% CI 0.90-1.05), respectively. Phenolic acid intake, highly correlated with coffee consumption, was inversely associated with colon cancer in men (HRlog2 = 0.91, 95% CI 0.85-0.97) and positively associated with rectal cancer in women (HRlog2 = 1.10, 95% CI 1.02-1.19); although associations did not exceed the Bonferroni threshold for significance. Intake of other polyphenol classes was not related to colorectal, colon or rectal cancer risks. Our study suggests a possible inverse association between phenolic acid intake and colon cancer risk in men and positive with rectal cancer risk in women.

37. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Anne Tjønneland, Valeria Pala, Augustin Scalbert, Tilman Kühn, Yahya Mahamat-Saleh, Bodil Ohlsson, Elissavet Valanou, Heiner Boeing, Torkjel M. Sandanger, Kim Overvad, Effie Vasilopoulou, Lena Maria Nilsson, Heinz Freisling, Marie-Christine Boutron-Ruault, Paolo Vineis, Amanda J. Cross, Salvatore Panico, Antonio Agudo, Kathryn E. Bradbury, Carmen Navarro, Giovanna Masala, Isabelle Romieu, Cristina Lasheras, Nicholas J. Wareham, Pilar Amiano, Veronika Fedirko, Mazda Jenab, Franck Carbonnel, Cecilie Kyrø, Fulvio Ricceri, Raul Zamora-Ros, Rosario Tumino, Kay Thee Khaw, María José Sánchez, Rudolf Kaaks, Martin Rutegård, Emily Sonestedt, Marko Lukic, Antonia Trichopoulou, Eva Ardanaz, Elisabete Weiderpass, Bas Bueno-de-Mesquita, Petra H.M. Peeters, Joseph A. Rothwell, Krasimira Aleksandrova, Valerie Cayssials, Department of Medical and Clinical Genetics, Medicum, University of Helsinki, Zamora-Ros, Raul, Cayssials, Valerie, Jenab, Mazda, Rothwell, Joseph A, Fedirko, Veronika, Aleksandrova, Krasimira, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Mahamat-Saleh, Yahya, Kaaks, Rudolf, Kühn, Tilman, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elissavet, Vasilopoulou, Effie, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Weiderpass, Elisabete, Lukic, Marko, Sandanger, Torkjel M, Lasheras, Cristina, Agudo, Antonio, Sánchez, Maria-Jose, Amiano, Pilar, Navarro, Carmen, Ardanaz, Eva, Sonestedt, Emily, Ohlsson, Bodil, Nilsson, Lena Maria, Rutegård, Martin, Bueno-de-Mesquita, Ba, Peeters, Petra H, Khaw, Kay-Thee, Wareham, Nicholas J, Bradbury, Kathryn, Freisling, Heinz, Romieu, Isabelle, Cross, Amanda J, Vineis, Paolo, Scalbert, Augustin, Zamora-Ros, Raul [0000-0002-6236-6804], and Apollo - University of Cambridge Repository
Subjects: 0301 basic medicine, Oncology, Male, Colorectal cancer, Epidemiology, Coffee, METABOLOME, Cohort Studies, 0302 clinical medicine, Surveys and Questionnaires, Medicine, Prospective Studies, Prospective cohort study, Public, Environmental & Occupational Health, GUT MICROBIOTA, food and beverages, ASSOCIATION, Middle Aged, 3142 Public health care science, environmental and occupational health, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Europe, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Polifenols, Cohort, Intake, COFFEE CONSUMPTION, Female, Colorectal Neoplasms, intake, Life Sciences & Biomedicine, Cohort study, FLAVONOID INTAKE, Polyphenol, COUNTRIES, Adult, medicine.medical_specialty, BIOMARKERS, prospective cohort, Rectum, Dietary Polyphenol, Article, 1117 Public Health and Health Services, 03 medical and health sciences, Càncer colorectal, Internal medicine, Diet, EPIC, Polyphenols, Prospective cohort, Aged, Follow-Up Studies, Humans, Tea, Nutrition Assessment, METAANALYSIS, Science & Technology, Proportional hazards model, business.industry, medicine.disease, 030104 developmental biology, diet, business
Abstract: The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. European Research Council (ERC-2009-AdG 232997); Health Research Fund (FIS): PI13/00061 to Granada; PI13/01162 to EPICMurcia, Regional Governments of Andalucı´a, Asturias, Basque Country, Murcia and Navarra, AGAUR - Generalitat de Catalunya (exp. 2014 SGR 726), The Health Research Funds RD12/0036/0018, cofunded by European Regional Development Fund (ERDF) ‘‘A way to build Europe (Spain);RZ-R was supported by the ‘‘Miguel Servet’’ program (CP15/00100) from the Institute of Health Carlos III and European Social Fund (ESF). (...), Zamora-Ros, R., Cayssials, V., Jenab, M., Rothwell, J.A., Fedirko, V., Aleksandrova, K., Tjønneland, A., Kyrø, C., Overvad, K., Boutron-Ruault, M.-C., Carbonnel, F., Mahamat-Saleh, Y., Kaaks, R., Kühn, T., Boeing, H., Trichopoulou, A., Valanou, E., Vasilopoulou, E., Masala, G., Pala, V., Panico, S., Tumino, R., Ricceri, F., Weiderpass, E., Lukic, M., Sandanger, T.M., Lasheras, C., Agudo, A., Sánchez, M.-J., Amiano, P., Navarro, C., Ardanaz, E., Sonestedt, E., Ohlsson, B., Nilsson, L.M., Rutegård, M., Bueno-de-Mesquita, B., Peeters, P.H., Khaw, K.-T., Wareham, N.J., Bradbury, K., Freisling, H., Romieu, I., Cross, A.J., Vineis, P., Scalbert, A.
Published: 2018
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38. Physical activity, mediating factors and risk of colon cancer:insights into adiposity and circulating biomarkers from the EPIC cohort

Author: Catalina Bonet, Antonia Trichopoulou, Dagmar Drogan, Tilman Kühn, Elisabete Weiderpass, Dagfinn Aune, Pagona Lagiou, Elio Riboli, Kim Overvad, Rosario Tumino, Kay-Tee Khaw, Miren Dorronsoro, María José Sánchez, A. M. May, Marion Carayol, Elissavet Valanou, Christina C. Dahm, Kristin Benjaminsen Borch, Christina Bamia, Marie Christine Bouton-Ruault, Krasimira Aleksandrova, Tobias Pischon, Patrik Wennberg, Aurelio Barricarte, Rudolf Kaaks, Heather Ward, Sunday Oluwafemi Oyeyemi, Nada Assi, Eleni Peppa, Domenico Palli, Bethany Van Guelpen, Mazda Jenab, Anne Tjønneland, Jonna K. van Vulpen, Timothy J. Key, Sabina Rinaldi, Heiner Boeing, Paula Jakszyn, Heinz Freisling, Carmen Navarro, Salvatore Panico, Carlo La Vecchia, J. Ramón Quirós, Claudia Agnoli, Nicholas J. Wareham, Bas Bueno-de-Mesquita, Carlotta Sacerdote, Michael F. Leitzmann, Imperial College Trust, Aleksandrova, Krasimira, Jenab, Mazda, Leitzmann, Michael, Bueno de mesquita, Ba, Kaaks, Rudolf, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Rinaldi, Sabina, Freisling, Heinz, Carayol, Marion, Pischon, Tobia, Drogan, Dagmar, Weiderpass, Elisabete, Jakszyn, Paula, Overvad, Kim, Dahm, Christina C, Tjønneland, Anne, Bouton ruault, Marie christine, Kühn, Tilman, Peppa, Eleni, Valanou, Elissavet, La Vecchia, Carlo, Palli, Domenico, Panico, Salvatore, Sacerdote, Carlotta, Agnoli, Claudia, Tumino, Rosario, May, Anne, Van Vulpen, Jonna, Benjaminsen Borch, Kristin, Oluwafemi Oyeyemi, Sunday, Quirós, J. Ramón, Bonet, Catalina, Sánchez, María josé, Dorronsoro, Miren, Navarro, Carmen, Barricarte, Aurelio, Van Guelpen, Bethany, Wennberg, Patrik, Key, Timothy J, Khaw, Kay tee, Wareham, Nichola, Assi, Nada, Ward, Heather A, Aune, Dagfinn, Riboli, Elio, and Boeing, Heiner
Subjects: Oncology, Male, SOLUBLE LEPTIN RECEPTOR, Colorectal cancer, Epidemiology, physical activity, law.invention, Body Mass Index, COLORECTAL-CANCER, 0302 clinical medicine, Randomized controlled trial, Weight loss, law, Risk Factors, 030212 general & internal medicine, Prospective Studies, Vitamin D, VITAMIN-D, Public, Environmental & Occupational Health, METABOLIC SYNDROME, adiposity, Leptin, 0104 Statistics, General Medicine, Middle Aged, SERUM-LEVELS, Europe, NUTRITION COHORT, 1117 Public Health And Health Services, colon cancer, 030220 oncology & carcinogenesis, Cohort, Colonic Neoplasms, biomarker, Female, medicine.symptom, Waist Circumference, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, WEIGHT-LOSS, CONTROLLED-TRIAL, Article, 03 medical and health sciences, Internal medicine, medicine, Vitamin D and neurology, Journal Article, Humans, mediating factors, Exercise, METAANALYSIS, Aged, Science & Technology, RECTAL CANCERS, business.industry, Physical activity, biomarkers, medicine.disease, Logistic Models, Case-Control Studies, Metabolic syndrome, business
Abstract: Background: There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer.Methods: We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline.Results: High physical activity was associated with a lower risk of colon cancer: relative risk ≥91 MET-h/week vs Conclusions: Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.
Published: 2017
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39. Cross-sectional associations of objectively measured physical activity, cardiorespiratory fitness and anthropometry in European adults.

Author: Wientzek A, Tormo Díaz MJ, Castaño JM, Amiano P, Arriola L, Overvad K, Østergaard JN, Charles MA, Fagherazzi G, Palli D, Bendinelli B, Skeie G, Borch KB, Wendel-Vos W, de Hollander E, May AM, den Ouden ME, Trichopoulou A, Valanou E, Söderberg S, Franks PW, Brage S, Vigl M, Boeing H, and Ekelund U
Subjects: Adult, Body Mass Index, Body Weight, Cross-Sectional Studies, Europe, Exercise Test methods, Female, Healthy Volunteers, Humans, Male, Middle Aged, Obesity prevention & control, Prospective Studies, Sedentary Behavior, Waist Circumference, Cardiovascular System metabolism, Motor Activity, Physical Fitness, White People
Abstract: Objective: To quantify the independent associations between objectively measured physical activity (PA), cardiorespiratory fitness (CRF), and anthropometry in European men and women., Methods: 2,056 volunteers from 12 centers across Europe were fitted with a heart rate and movement sensor at 2 visits 4 months apart for a total of 8 days. CRF (ml/kg/min) was estimated from an 8 minute ramped step test. A cross-sectional analysis of the independent associations between objectively measured PA (m/s(2)/d), moderate and vigorous physical activity (MVPA) (%time/d), sedentary time (%time/d), CRF, and anthropometry using sex stratified multiple linear regression was performed., Results: In mutually adjusted models, CRF, PA, and MVPA were inversely associated with all anthropometric markers in women. In men, CRF, PA, and MVPA were inversely associated with BMI, whereas only CRF was significantly associated with the other anthropometric markers. Sedentary time was positively associated with all anthropometric markers, however, after adjustment for CRF significant in women only., Conclusion: CRF, PA, MVPA, and sedentary time are differently associated with anthropometric markers in men and women. CRF appears to attenuate associations between PA, MVPA, and sedentary time. These observations may have implications for prevention of obesity., (Copyright © 2013 The Obesity Society.)
Published: 2014
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