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Background. Hyperprolactinemia can lead to negative cardiovascular events in patients with coronary heart di­sease and slow down the regeneration of the gastrointestinal tract mucous membrane. The purpose of the study was to determine the possible relationship between prolactin levels and the results of Holter electrocardiography (ECG) monitoring in patients with stable angina and gastroesophageal reflux disease (GERD). Materials and methods. The study included 118 patients with angina pectoris of I–II functional class. Of these, 88 patients with stable angina and comorbid GERD (A, B, C) were included in the second group, and 30 patients with isolated stable angina formed the first group. All patients who were included in the study prior to treatment were evaluated for serum prolactin levels and Holter ECG monitoring. Results. In patients with stable angina and GERD, prolactin levels exceed the norm and were higher than that of the group with isolated stable angina (p

Objective: to elucidate clinical, ultrasonographic, and biochemical features of the course of non-alcoholic steatohepatitis (NASH) for comorbidity with grade 1 obesity, chronic obstructive pulmonary disease (COPD) of 2–3 D stages compared with NASH during obesity without COPD by studying the frequency and intensity of leading clinical and biochemical syndromes of NASH, comparison of ultrasonographic (USG) characteristics of NASH depending on the presence of COPD. Material and methods. 105 NASH patients were examined: 52 NASH patients with grade 1 obesity (1 group) (there were 18 men, 24 women); 53 NASH patients with comorbid grade 1 obesity and COPD of 2–3 D stages (group 2) (there were 28 men, 13 women). In order to determine the dependence of NASH on the presence of COPD, groups of patients were randomized by the age and the degree of obesity. The average age of the patients was (55,7 ± 3,22) years. The functional condition of the liver was determined by the generally accepted lists of enzyme activity, markers of pigment and nitrogen metabolism, proteinograms, lipidograms, ionograms, calculation of de Ritis ratio, and the USG was performed. In order to quantify the changes in liver echogenicity we have used the method of echodensitometry with the calculation of the hepatorenal index. Results. The symptoms of astheno-vegetative syndrome, dyspepsia and feeling of heaviness or pain while palpating in the right hypochondrium were observed in 2,1 times, 1,7 times and 2,5 times (p

Objective - to study the histochemical and histological features of the liver and lungtissues in patients with non-alcoholic steatohepatitis (NASH) and obesity under conditionof a comorbid course with chronic obstructive pulmonary disease (COPD).Material and methods. The autopsy material of 27 cases with NASH, including 13 casesof NASH and obesity of I degree (group 1), 14 cases of NASH, obesity of I degree withcomorbid COPD of II-III stage (group 2) was used. The groups of comparison includedautopsy material of 12 patients with isolated COPD of II-III stage (Group 3), as wellas 11 practically healthy persons (PHP), their main causes of death were polytraumaor traumatic brain injury or sudden coronary death. The groups were randomizedaccording to age, sex, degree of obesity. The average age of patients was (59,3 ± 3,21)years.Results. The volume of the connective tissue (CT) in the liver parenchyma in the 2nd groupwas in 1,9 times higher than in the 1st group (p

The aim – to study some histopathological features of the iron overload syndromeformation in patients suffering from steatohepatitis depending on its etiology.Material and methods. Liver biopsies were analyzed in 30 patients with nonalcoholicsteatohepatitis (NASH) and 20 patients with alcoholic steatohepatitis (ASH). Themorphological examination of the liver was carried out according to the standardmethods. The histopathological features of the liver were established on the basis ofthe method of staining with hematoxylin and eosin, with the confirmation, in case ofnecessity, by the histochemical methods - staining for fat (the method with Sudan-III) andcollagen fibers (the method with chromotropic-water blue according to N.Z Slinchenko).Microspectrophotometric studies were conducted using a cytological analyzer withsoftware "VideoTest - Size 5.0" (2000).Results. The same regularities for both trivalent iron and twovalent iron were revealed asa whole in the liver cells at histological investigations, that is in ASH the optical densityis at the average 1.3 (p