1. Synthesis of N1,N1,N3,N3-tetrasubstituted diethylenetriamines
- Author
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N. Yu. Borisova, E. Ya. Borisova, D. Q. Hoang, V. K. Lesnikov, and A. V. Krylov
- Subjects
0301 basic medicine ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,13c nmr spectroscopy ,Chemistry ,Electrospray ionization ,Ethylenediamines ,Infrared spectroscopy ,Ammonium ,General Chemistry ,Nuclear chemistry - Abstract
Preparative procedures for the synthesis of N1,N1,N3,N3-tetrasubstituted diethylenetriamines via aminoalkylation of N,N-disubstituted ethylenediamines with N,N-disubstituted 2-chloroethylamines were developed. Aminoalkylation of N,N-dimethylethylenediamine under heating gave simultaneously secondary N1,N1,N3,N3-tetrasubstituted diethylenetriamines and quaternary ammonium salts, N-(2-aminoethyl)-N-(2-dialkylaminoethyl)-N,N-dimethylammonium chlorides. Structures of the synthesized compounds were established by IR spectroscopy, 1H and 13C NMR spectroscopy, and electrospray ionization mass spectrometry.
- Published
- 2018
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