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1. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study

Author

Hakola, Leena, Mramba, Lazarus K., Uusitalo, Ulla, Andrén Aronsson, Carin, Hummel, Sandra, Niinistö, Sari, Erlund, Iris, Yang, Jimin, Rewers, Marian J., Akolkar, Beena, McIndoe, Richard A., Rich, Stephen S., Hagopian, William A., Ziegler, Anette, Lernmark, Åke, Toppari, Jorma, Krischer, Jeffrey P., Norris, Jill M., and Virtanen, Suvi M.

Published
2024
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3. Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk

Author

Hård af Segerstad, Elin M., Mramba, Lazarus K., Liu, Xiang, Uusitalo, Ulla, Yang, Jimin, Norris, Jill, Virtanen, Suvi M., Liu, Edwin, Kurppa, Kalle, Koletzko, Sibylle, Ziegler, Annette G., Toppari, Jorma, Rewers, Marian, Akolkar, Beena, Krischer, Jeffrey P., Aronsson, Carin Andrén, and Agardh, Daniel

Published
2023
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4. Metabolomics‐related nutrient patterns at seroconversion and risk of progression to type 1 diabetes

Author

Johnson, Randi K, Vanderlinden, Lauren A, DeFelice, Brian C, Uusitalo, Ulla, Seifert, Jennifer, Fan, Sili, Crume, Tessa, Fiehn, Oliver, Rewers, Marian, Kechris, Katerina, and Norris, Jill M

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Nutrition and Dietetics, Prevention, Nutrition, Diabetes, Pediatric, Autoimmune Disease, Metabolic and endocrine, Autoimmunity, Child, Child, Preschool, Diabetes Mellitus, Type 1, Diet, Disease Progression, Female, Humans, Islets of Langerhans, Male, Metabolomics, Nutrients, Proportional Hazards Models, Risk Factors, Seroconversion, Surveys and Questionnaires, dietary intake, metabolomics, nutrient patterns, progression, T1D, Paediatrics and Reproductive Medicine, Endocrinology & Metabolism, Clinical sciences, Paediatrics
Abstract

ObjectiveOur aim was to elucidate the role of diet in type 1 diabetes (T1D) by examining combinations of nutrient intake in the progression from islet autoimmunity (IA) to T1D.MethodsWe measured 2457 metabolites and dietary intake at the time of seroconversion in 132 IA-positive children in the prospective Diabetes Autoimmunity Study in the Young. IA was defined as the first of two consecutive visits positive for at least one autoantibody (insulin, GAD, IA-2, or ZnT8). By December 2018, 40 children progressed to T1D. Intakes of 38 nutrients were estimated from semiquantitative food frequency questionnaires. We tested the association of each metabolite with progression to T1D using multivariable Cox regression. Nutrient patterns that best explained variation in candidate metabolites were identified using reduced rank regression (RRR), and their association with progression to T1D was tested using Cox regression adjusting for age at seroconversion and high-risk HLA genotype.ResultsIn stepwise selection, 22 nutrients significantly predicted at least two of the 13 most significant metabolites associated with progression to T1D, and were included in RRR. A nutrient pattern corresponding to intake lower in linoleic acid, niacin, and riboflavin, and higher in total sugars, explained 18% of metabolite variability. Children scoring higher on this metabolite-related nutrient pattern at seroconversion had increased risk for progressing to T1D (HR = 3.17, 95%CI = 1.42-7.05).ConclusionsCombinations of nutrient intake reflecting candidate metabolites are associated with increased risk of T1D, and may help focus dietary prevention efforts.

Published
2020

5. Metabolite-related dietary patterns and the development of islet autoimmunity.

Author

Johnson, Randi K, Vanderlinden, Lauren, DeFelice, Brian C, Kechris, Katerina, Uusitalo, Ulla, Fiehn, Oliver, Sontag, Marci, Crume, Tessa, Beyerlein, Andreas, Lernmark, Åke, Toppari, Jorma, Ziegler, Anette-G, She, Jin-Xiong, Hagopian, William, Rewers, Marian, Akolkar, Beena, Krischer, Jeffrey, Virtanen, Suvi M, Norris, Jill M, and TEDDY Study Group

Subjects
TEDDY Study Group
Abstract

The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts.

Published
2019

7. HLA genotype and probiotics modify the association between timing of solid food introduction and islet autoimmunity in the TEDDY Study

Author

Hagopian, William, primary, Uusitalo, Ulla, primary, Mramba, Lazarus K., primary, Aronsson, Carin Andrén, primary, Vehik, Kendra, primary, Yang, Jimin, primary, Hummel, Sandra, primary, Lernmark, Åke, primary, Rewers, Marian, primary, McIndoe, Richard, primary, Toppari, Jorma, primary, Ziegler, Anette G., primary, Akolkar, Beena, primary, Krischer, Jeffrey P., primary, Virtanen, Suvi M., primary, and Norris, Jill M., primary

Published
2023
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9. HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study.

Author

Uusitalo, Ulla, Mramba, Lazarus K., Aronsson, Carin Andrén, Vehik, Kendra, Yang, Jimin, Hummel, Sandra, Lernmark, Åke, Rewers, Marian, Hagopian, William, McIndoe, Richard, Toppari, Jorma, Ziegler, Anette-G., Akolkar, Beena, Krischer, Jeffrey P., Virtanen, Suvi M., and Norris, Jill M.

Subjects
*BABY foods, *PROPORTIONAL hazards models, *TYPE 1 diabetes, *GENOTYPES, *PROBIOTICS, *AUTOIMMUNITY, *JUNK food
Abstract

OBJECTIVE: To study the interaction among HLA genotype, early probiotic exposure, and timing of complementary foods in relation to risk of islet autoimmunity (IA). RESEARCH DESIGN AND METHODS: The Environmental Determinants of Diabetes in the Young (TEDDY) study prospectively follows 8,676 children with increased genetic risk of type 1 diabetes. We used a Cox proportional hazards regression model adjusting for potential confounders to study early feeding and the risk of IA in a sample of 7,770 children. RESULTS: Any solid food introduced early (<6 months) was associated with increased risk of IA if the child had the HLA DR3/4 genotype and no probiotic exposure during the 1st year of life. Rice introduced at 4–5.9 months compared with later in the U.S. was associated with an increased risk of IA. CONCLUSIONS: Timing of solid food introduction, including rice, may be associated with IA in children with the HLA DR3/4 genotype not exposed to probiotics. The microbiome composition under these exposure combinations requires further study. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Interaction between dietary iron intake and genetically determined iron overload: risk of islet autoimmunity and progression to type 1 diabetes in the TEDDY study

Author

Thorsen, Steffen U., primary, Liu, Xiang, primary, Kataria, Yachana, primary, Mandrup-Poulsen, Thomas, primary, Kaur, Simranjeet, primary, Uusitalo, Ulla, primary, Virtanen, Suvi M., primary, M. Norris, Jill, primary, Rewers, Marian, primary, Hagopian, William, primary, Yang, Jimin, primary, She, Jin-Xiong, primary, Akolkar, Beena, primary, Rich, Stephen, primary, Aronsson, Carin Andrén, primary, Lernmark, Åke, primary, Ziegler, Anette-Gabriele, primary, Toppari, Jorma, primary, Krischer, Jeffrey, primary, Parikh, Hemang M., primary, Ellervik, Christina, primary, Svensson, Jannet, primary, and Group, the TEDDY Study, primary

Published
2023
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11. Dietary Intake and Body Mass Index Influence the Risk of Islet Autoimmunity in Genetically At-Risk Children: A Mediation Analysis Using the TEDDY Cohort

Author

Andrén Aronsson, Carin, primary, Tamura, Roy, additional, Vehik, Kendra, additional, Uusitalo, Ulla, additional, Yang, Jimin, additional, Haller, Michael J., additional, Toppari, Jorma, additional, Hagopian, William, additional, McIndoe, Richard A., additional, Rewers, Marian J., additional, Ziegler, Anette-G., additional, Akolkar, Beena, additional, Krischer, Jeffrey P., additional, Norris, Jill M., additional, Virtanen, Suvi M., additional, and Elding Larsson, Helena, additional

Published
2023
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12. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort

Author

Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Frohnert, Brigitte I., Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Foghis, Gabriela, Anderson, Stephen W., Robinson, Richard, Ziegler, Anette G., Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Stock, Joanna, Strauss, Elisabeth, Warncke, Katharina, Winkler, Christiane, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Kähönen, Miia, Knip, Mikael, Koivu, Annika, Koreasalo, Mirva, Kurppa, Kalle, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Romo, Minna, Simell, Satu, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Särmä, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M., Vähä-Mäkilä, Mari, Åkerlund, Mari, Lernmark, Åke, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Harmby, Cecilia, Hyberg, Susanne, Johansen, Fredrik, Jonasdottir, Berglind, Larsson, Helena Elding, Forss, Sigrid Lenrick, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Rahmati, Kobra, Ramelius, Anita, Rosenquist, Anna, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Trulsson, Erika, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A., Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Ayres, Stephen, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Scott, Elizabeth, Stabbert, Joshua, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P., Abbondondolo, Michael, Austin-Gonzalez, Sarah, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Laras, Francisco Perez, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, McLeod, Wendy, Meulemans, Steven, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Ballard, Lori, Hadley, David, Akolkar, Beena, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric, Andrén Aronsson, Carin, and Norris, Jill M.

Published
2016
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13. Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study

Author

TEDDY Study Group, Mehta, Pooja, Li, Qian, Stahl, Marisa, Uusitalo, Ulla, Lindfors, Katri, Butterworth, Martha D., Kurppa, Kalle, Virtanen, Suvi, Koletzko, Sibylle, Aronsson, Carin, Hagopian, William A., Rewers, Marian J., Toppari, Jorma, Ziegler, Anette G., Akolkar, Beena, Krischer, Jeffrey P., Agardh, Daniel, Liu, Edwin, Tampere University, BioMediTech, Department of Paediatrics, Clinical Medicine, Seinäjoen keskussairaala VA, and Health Sciences

Subjects
Multidisciplinary, 3123 Gynaecology and paediatrics, 3121 Internal medicine, 3142 Public health care science, environmental and occupational health
Abstract

Background Celiac disease has an increasing incidence worldwide and is treated with lifelong adherence to a gluten-free diet. We aimed to describe gluten-free diet adherence rates in children with screening-identified celiac disease, determine adherence-related factors, and compare adherence to food records in a multinational prospective birth cohort study. Methods Children in The Environmental Determinants of Diabetes in the Young study with celiac disease were included. Subjects had at least annual measurement of adherence (parent-report) and completed 3-day food records. Descriptive statistics, t-tests, Kruskal-Wallis tests and multivariable logistic and linear regression were employed. Results Two hundred ninety (73%) and 199 (67%) of subjects were always adherent to a gluten-free diet at 2 and 5 years post celiac disease diagnosis respectively. The percentage of children with variable adherence increased from 1% at 2 years to 15% at 5 years. Children with a first-degree relative with celiac disease were more likely to be adherent to the gluten-free diet. Gluten intake on food records could not differentiate adherent from nonadherent subjects. Adherent children from the United States had more gluten intake based on food records than European children (P < .001 and P = .007 at 2 and 5 years respectively). Conclusion Approximately three-quarters of children with screening-identified celiac disease remain strictly adherent to a gluten-free diet over time. There are no identifiable features associated with adherence aside from having a first-degree relative with celiac disease. Despite good parent-reported adherence, children from the United States have more gluten intake when assessed by food records. Studies on markers of gluten-free diet adherence, sources of gluten exposure (particularly in the United States), and effects of adherence on mucosal healing are needed.

Published
2023

17. Joint modeling of longitudinal autoantibody patterns and progression to type 1 diabetes: results from the TEDDY study

Author

Köhler, Meike, Beyerlein, Andreas, Vehik, Kendra, Greven, Sonja, Umlauf, Nikolaus, Lernmark, Åke, Hagopian, William A., Rewers, Marian, She, Jin-Xiong, Toppari, Jorma, Akolkar, Beena, Krischer, Jeffrey P., Bonifacio, Ezio, Ziegler, Anette-G., Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Driscoll, Kimberly, Frohnert, Brigitte I., Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Ahonen, Suvi, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Karlsson, Leena, Kähönen, Miia, Knip, Mikael, Kovanen, Lea, Koreasalo, Mirva, Kurppa, Kalle, Latva-aho, Tiina, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Niinistö, Sari, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Riikonen, Mika, Rouhiainen, Jenni, Romo, Minna, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Leppänen, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M., Vähä-Mäkilä, Mari, Åkerlund, Mari, Lindfors, Katri, She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Young, Gabriela, Anderson, Stephen W., Jacobsen, Laura, Ziegler, Anette G., Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Janz, Nicole, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Scholz, Marlon, Stock, Joanna, Warncke, Katharina, Wendel, Lorena, Winkler, Christiane, Lernmark, Åke, Agardh, Daniel, Aronsson, Carin Andrén, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Hyberg, Susanne, Johansen, Fredrik, Jonsdottir, Berglind, Larsson, Helena Elding, Lindström, Marielle, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Ottosson, Karin, Rahmati, Kobra, Ramelius, Anita, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A., Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Carson, Josephine, Dalzell, Maria, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P., Abbondondolo, Michael, Austin-Gonzalez, Sarah, Avendano, Maryouri, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, PerezLaras, Francisco, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, Meulemans, Steven, Parikh, Hemang, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Ballard, Lori, Hadley, David, McLeod, Wendy, Akolkar, Beena, Yu, Liping, Miao, Dongmei, Bingley, Polly, Williams, Alistair, Chandler, Kyla, Rokni, Saba, Williams, Claire, Wyatt, Rebecca, George, Gifty, Grace, Sian, Erlich, Henry, Mack, Steven J., Ke, Sandra, Mulholland, Niveen, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, Triplett, Eric, TEDDY study group, Ancillary Studies, Diet, Genetics, Human Subjects/Publicity/Publications, Immune Markers, Infectious Agents, Laboratory Implementation, Maternal Studies, Psychosocial, Quality Assurance, Steering, Study Coordinators, Celiac Disease, Clinical Implementation, and Quality Assurance Subcommittee on Data Quality

Published
2017
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19. Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study.

Author

Thorsen, Steffen U., Liu, Xiang, Kataria, Yachana, Mandrup-Poulsen, Thomas, Kaur, Simranjeet, Uusitalo, Ulla, Virtanen, Suvi M., Norris, Jill M., Rewers, Marian, Hagopian, William, Yang, Jimin, She, Jin-Xiong, Akolkar, Beena, Rich, Stephen, Aronsson, Carin Andrén, Lernmark, Åke, Ziegler, Anette-Gabriele, Toppari, Jorma, Krischer, Jeffrey, and Parikh, Hemang M.

Subjects
TYPE 1 diabetes, IRON overload, FOOD consumption, IRON, DISEASE risk factors
Abstract

OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron. RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake. CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Dietary patterns during early childhood confer different risk of celiac disease autoimmunity and celiac disease in children at genetic risk: TEDDY study

Author

Elin M Hård af Segerstad, Mramba, Lazarus K., Xiang Liu, Uusitalo, Ulla M., Jimin Yang, Jill Norris, Sm, Virtanen, Edwin Liu, Kalle Kurppa, Sibylle Koletzko, Anette Ziegler, Jorma Toppari, Hagopian, William A., Marian Rewers, Richard McIndoe, Beena Akolkar, Jeffrey Krischer, Carin Andrén Aronsson, Daniel Agardh, and Teddy, Study Group

Subjects
Endocrinology and Diabetes
Published
2022

21. Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study.

Author

Mehta, Pooja, Li, Qian, Stahl, Marisa, Uusitalo, Ulla, Lindfors, Katri, Butterworth, Martha D., Kurppa, Kalle, Virtanen, Suvi, Koletzko, Sibylle, Aronsson, Carin, Hagopian, William A., Rewers, Marian J., Toppari, Jorma, Ziegler, Anette-G., Akolkar, Beena, Krischer, Jeffrey P., Agardh, Daniel, and Liu, Edwin

Subjects
CELIAC disease, GLUTEN-free diet, COHORT analysis, FOOD consumption, KRUSKAL-Wallis Test, MULTIVARIABLE testing
Abstract

Background: Celiac disease has an increasing incidence worldwide and is treated with lifelong adherence to a gluten-free diet. We aimed to describe gluten-free diet adherence rates in children with screening-identified celiac disease, determine adherence-related factors, and compare adherence to food records in a multinational prospective birth cohort study. Methods: Children in The Environmental Determinants of Diabetes in the Young study with celiac disease were included. Subjects had at least annual measurement of adherence (parent-report) and completed 3-day food records. Descriptive statistics, t-tests, Kruskal-Wallis tests and multivariable logistic and linear regression were employed. Results: Two hundred ninety (73%) and 199 (67%) of subjects were always adherent to a gluten-free diet at 2 and 5 years post celiac disease diagnosis respectively. The percentage of children with variable adherence increased from 1% at 2 years to 15% at 5 years. Children with a first-degree relative with celiac disease were more likely to be adherent to the gluten-free diet. Gluten intake on food records could not differentiate adherent from nonadherent subjects. Adherent children from the United States had more gluten intake based on food records than European children (P <.001 and P =.007 at 2 and 5 years respectively). Conclusion: Approximately three-quarters of children with screening-identified celiac disease remain strictly adherent to a gluten-free diet over time. There are no identifiable features associated with adherence aside from having a first-degree relative with celiac disease. Despite good parent-reported adherence, children from the United States have more gluten intake when assessed by food records. Studies on markers of gluten-free diet adherence, sources of gluten exposure (particularly in the United States), and effects of adherence on mucosal healing are needed. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort

Author

Aronsson, Carin Andrén, Lee, Hye-Seung, Koletzko, Sibylle, Uusitalo, Ulla, Yang, Jimin, Virtanen, Suvi M., Liu, Edwin, Lernmark, Åke, Norris, Jill M., Agardh, Daniel, Rewers, Marian, Bautista, Kimberly, Baxter, Judith, Bedoy, Ruth, Felipe-Morales, Daniel, Frohnert, Brigitte I., Gesualdo, Patricia, Hoffman, Michelle, Karban, Rachel, Liu, Edwin, Norris, Jill, Samper-Imaz, Adela, Steck, Andrea, Waugh, Kathleen, Wright, Hali, She, Jin-Xiong, Schatz, Desmond, Hopkins, Diane, Steed, Leigh, Thomas, Jamie, Adams, Janey, Silvis, Katherine, Haller, Michael, Gardiner, Melissa, McIndoe, Richard, Sharma, Ashok, Williams, Joshua, Foghis, Gabriela, Anderson, Stephen W., Robinson, Richard, Ziegler, Anette G., Beyerlein, Andreas, Bonifacio, Ezio, Hummel, Michael, Hummel, Sandra, Foterek, Kristina, Kersting, Mathilde, Knopff, Annette, Koletzko, Sibylle, Peplow, Claudia, Roth, Roswith, Stock, Joanna, Strauss, Elisabeth, Warncke, Katharina, Winkler, Christiane, Toppari, Jorma, Simell, Olli G., Adamsson, Annika, Hyöty, Heikki, Ilonen, Jorma, Jokipuu, Sanna, Kallio, Tiina, Kähönen, Miia, Knip, Mikael, Koivu, Annika, Koreasalo, Mirva, Kurppa, Kalle, Lönnrot, Maria, Mäntymäki, Elina, Multasuo, Katja, Mykkänen, Juha, Niininen, Tiina, Nyblom, Mia, Rajala, Petra, Rautanen, Jenna, Riikonen, Anne, Romo, Minna, Simell, Satu, Simell, Tuula, Simell, Ville, Sjöberg, Maija, Stenius, Aino, Särmä, Maria, Vainionpää, Sini, Varjonen, Eeva, Veijola, Riitta, Virtanen, Suvi M., Vähä-Mäkilä, Mari, Åkerlund, Mari, Lernmark, Åke, Agardh, Daniel, Ask, Maria, Bremer, Jenny, Carlsson, Ulla-Marie, Cilio, Corrado, Ericson-Hallström, Emelie, Fransson, Lina, Gard, Thomas, Gerardsson, Joanna, Bennet, Rasmus, Hansen, Monica, Hansson, Gertie, Harmby, Cecilia, Hyberg, Susanne, Johansen, Fredrik, Jonasdottir, Berglind, Larsson, Helena Elding, Forss, Sigrid Lenrick, Lundgren, Markus, Månsson-Martinez, Maria, Markan, Maria, Melin, Jessica, Mestan, Zeliha, Rahmati, Kobra, Ramelius, Anita, Rosenquist, Anna, Salami, Falastin, Sibthorpe, Sara, Sjöberg, Birgitta, Swartling, Ulrica, Amboh, Evelyn Tekum, Trulsson, Erika, Törn, Carina, Wallin, Anne, Wimar, Åsa, Åberg, Sofie, Hagopian, William A., Killian, Michael, Crouch, Claire Cowen, Skidmore, Jennifer, Ayres, Stephen, Dunson, Kayleen, Hervey, Rachel, Johnson, Corbin, Lyons, Rachel, Meyer, Arlene, Mulenga, Denise, Scott, Elizabeth, Stabbert, Joshua, Tarr, Alexander, Uland, Morgan, Willis, John, Becker, Dorothy, Franciscus, Margaret, Smith, MaryEllen Dalmagro-Elias, Daftary, Ashi, Klein, Mary Beth, Yates, Chrystal, Krischer, Jeffrey P., Abbondondolo, Michael, Austin-Gonzalez, Sarah, Baethke, Sandra, Brown, Rasheedah, Burkhardt, Brant, Butterworth, Martha, Clasen, Joanna, Cuthbertson, David, Eberhard, Christopher, Fiske, Steven, Garcia, Dena, Garmeson, Jennifer, Gowda, Veena, Heyman, Kathleen, Laras, Francisco Perez, Lee, Hye-Seung, Liu, Shu, Liu, Xiang, Lynch, Kristian, Malloy, Jamie, McCarthy, Cristina, McLeod, Wendy, Meulemans, Steven, Shaffer, Chris, Smith, Laura, Smith, Susan, Sulman, Noah, Tamura, Roy, Uusitalo, Ulla, Vehik, Kendra, Vijayakandipan, Ponni, Wood, Keith, Yang, Jimin, Ballard, Lori, Hadley, David, Akolkar, Beena, Bourcier, Kasia, Briese, Thomas, Johnson, Suzanne Bennett, and Triplett, Eric

Published
2016
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24. 25(OH)D Levels in Infancy Is Associated With Celiac Disease Autoimmunity in At-Risk Children: A Case–Control Study

Author

Andrén Aronsson, Carin, primary, Liu, Xiang, additional, Norris, Jill M., additional, Uusitalo, Ulla, additional, Butterworth, Martha D., additional, Koletzko, Sibylle, additional, Virtanen, Suvi M., additional, Erlund, Iris, additional, Kurppa, Kalle, additional, Hagopian, William A., additional, Rewers, Marian J., additional, She, Jin-Xiong, additional, Toppari, Jorma, additional, Ziegler, Anette-G., additional, Akolkar, Beena, additional, Krischer, Jeffrey P., additional, and Agardh, Daniel, additional

Published
2021
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25. Associations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study

Author

Hummel, Sandra, primary, Weiß, Andreas, additional, Bonifacio, Ezio, additional, Agardh, Daniel, additional, Akolkar, Beena, additional, Aronsson, Carin A, additional, Hagopian, William A, additional, Koletzko, Sibylle, additional, Krischer, Jeffrey P, additional, Lernmark, Åke, additional, Lynch, Kristian, additional, Norris, Jill M, additional, Rewers, Marian J, additional, She, Jin-Xiong, additional, Toppari, Jorma, additional, Uusitalo, Ulla, additional, Vehik, Kendra, additional, Virtanen, Suvi M, additional, Beyerlein, Andreas, additional, and Ziegler, Anette-G, additional

Published
2021
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26. Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity

Author

Niinistö, Sari, Erlund, Iris, Lee, Hye Seung, Uusitalo, Ulla, Salminen, Irma, Aronsson, Carin Andrén, Parikh, Hemang M., Liu, Xiang, Hummel, Sandra, Toppari, Jorma, She, Jin Xiong, Lernmark, Åke, Ziegler, Annette G., Rewers, Marian, Akolkar, Beena, Krischer, Jeffrey P., Galas, David, Das, Siba, Sakhanenko, Nikita, Rich, Stephen S., Hagopian, William, Norris, Jill M., Virtanen, Suvi M., The TEDDY Study Group., Tampere University, Health Sciences, and Department of Paediatrics

Subjects
Male, 0301 basic medicine, Erythrocytes, Conjugated linoleic acid, The Environmental Determinants of Diabetes in the Young, Autoimmunity, Pathogenesis, chemistry.chemical_compound, Endocrinology, 0302 clinical medicine, 3123 Gynaecology and paediatrics, Child, chemistry.chemical_classification, Multidisciplinary, geography.geographical_feature_category, Fatty Acids, Islet, Breast Feeding, Child, Preschool, Medicine, Female, Docosapentaenoic acid, Polyunsaturated fatty acid, medicine.medical_specialty, Science, 030209 endocrinology & metabolism, Lower risk, Article, Islets of Langerhans, 03 medical and health sciences, Internal medicine, medicine, Humans, geography, Type 1 diabetes, business.industry, Infant, Fatty acid, medicine.disease, 3141 Health care science, 030104 developmental biology, Risk factors, chemistry, Case-Control Studies, 3111 Biomedicine, business, Biomarkers
Abstract

Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case–control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n − 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n − 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.

Published
2021

33. Early probiotic supplementation and the risk of celiac disease in children at genetic risk

Author

Uusitalo, Ulla, Aronsson, Carin Andren, Liu, Xiang, Kurppa, Kalle, Ahonen, Suvi, Hyöty, Heikki, Koreasalo, Mirva, Lindfors, Katri, Mattila, Markus, Oikarinen, Sami, Riikonen, Anne, Virtanen, Suvi, Åkerlund, Mari, Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, and Tampere University

Subjects
Probiotics, Infant formula, Sisätaudit - Internal medicine, Celiac disease, Terveystiede - Health care science, Dietary supplements, Celiac disease autoimmunity
Published
2019

34. The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children

Author

Frank, Nicole M, Lynch, Kristian F, Uusitalo, Ulla, Hyöty, Heikki, Ahonen, Suvi, Koreasalo, Mirva, Kurppa, Kalle, Lindfors, Katri, Lönnrot, Maria, Mattila, Markus, Riikonen, Anne, Virtanen, Suvi, Åkerlund, Mari, Lääketieteen ja terveysteknologian tiedekunta - Faculty of Medicine and Health Technology, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, and Tampere University

Subjects
Gastrointestinal, Breastfeeding, Respiratory, Naisten- ja lastentaudit - Gynaecology and paediatrics, Infection, Illness, Otitis media, Gastroenteritis
Published
2019

35. Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced [beta] cell autoimmunity in the child

Author

Uusitalo, Liisa, Kenward, Mike G., Virtanen, Suvi M., Uusitalo, Ulla, Nevalainen, Jaakko, Niinisto, Sari, Kronberg-Kippila, Carina, Ovaskainen, Marja-Leena, Marjamaki, Liisa, Simell, Olli, Ilonen, Jorma, Veijola, Riitta, and Knip, Mikael

Subjects
Antioxidants -- Health aspects, Antioxidants -- Research, Trace elements in nutrition -- Health aspects, Trace elements in nutrition -- Research, Type 1 diabetes -- Risk factors, Type 1 diabetes -- Prevention, Type 1 diabetes -- Research, Food/cooking/nutrition, Health
Abstract

Background: Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes. Objective: We assessed whether high maternal intake of selected dietary antioxidants during pregnancy is associated with a reduced risk of advanced [beta] cell autoimmunity in the child, defined as repeated positivity for islet cell antibodies plus [greater than or equal to] 1 other antibody, overt type 1 diabetes, or both. Design: The study was carried out as part of the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention Project. The data comprised 4297 children with increased genetic susceptibility to type 1 diabetes, born at the University Hospital of Oulu or Tampere, Finland, between October 1997 and December 2002. The children were monitored for diabetes-associated autoantibodies from samples obtained at 3-12-mo intervals. Maternal antioxidant intake during pregnancy was assessed postnatally with a self-administered food-frequency questionnaire, which contained a question about consumption of dietary supplements. Results: Maternal intake of none of the studied antioxidant nutrients showed association with the risk of advanced [beta] cell autoimmunity in the child. The hazard ratios, indicating the change in risk per a 2-fold increase in the intake of each antioxidant, were nonsignificant and close to 1. Conclusion: High maternal intake of retinol [beta]-carotene, vitamin C, vitamin E, selenium, zinc, or manganese does not protect the child from development of advanced [beta] cell autoimmunity in early childhood.

Published
2008

36. Dietary Compliance in Diabetes Prevention Project in Finland

Author

Bärlund, Sonja, Uusitalo, Ulla, Kleemola, Päivi, Knip, Mikael, Åkerblom, Hans K., Virtanen, Suvi M., Back, Nathan, editor, Cohen, Irun R., editor, Kritchevsky, David, editor, Lajtha, Abel, editor, Paoletti, Rodolfo, editor, Koletzko, Berthold, editor, Dodds, Peter, editor, Akerblom, Hans, editor, and Ashwell, Margaret, editor

Published
2005
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37. Metabolite-related dietary patterns and the development of islet autoimmunity

Author

Johnson, Randi K., Vanderlinden, Lauren, DeFelice, Brian C., Kechris, Katerina, Uusitalo, Ulla, Fiehn, Oliver, Sontag, Marci, Crume, Tessa, Beyerlein, Andreas, Lernmark, Åke, Toppari, Jorma, Ziegler, Anette-G., She, Jin-Xiong, Hagopian, William, Rewers, Marian, Akolkar, Beena, Krischer, Jeffrey, Virtanen, Suvi M., Norris, Jill M., TEDDY study group, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, and Tampere University

Subjects
Male, 0301 basic medicine, Epidemiology, type 1 diabetes, Metabolite, The Environmental Determinants of Diabetes in the Young, lcsh:Medicine, Autoimmunity, medicine.disease_cause, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, lcsh:Science, Child, Pediatric, Multidisciplinary, Diabetes, Sisätaudit - Internal medicine, 3. Good health, ddc, Type 1 diabetes, Child, Preschool, Female, epidemiology, Child Nutritional Physiological Phenomena, Type 1, TEDDY Study Group, 030209 endocrinology & metabolism, Biology, Autoimmune Disease, Article, Islets of Langerhans, 03 medical and health sciences, Metabolomics, Lipidomics, Diabetes Mellitus, medicine, Humans, Seroconversion, Preschool, Metabolic and endocrine, Nutrition, Autoantibodies, Prevention, lcsh:R, Case-control study, Infant, Lipid Metabolism, medicine.disease, Diabetes Mellitus, Type 1, Early Diagnosis, 030104 developmental biology, chemistry, Case-Control Studies, Immunology, lcsh:Q, Follow-Up Studies
Abstract

The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts.

Published
2018

41. Part III. Can we turn back the clock or modify the adverse dynamics? Programme and policy issues: Influencing public nutrition for non-communicable disease prevention: from community intervention to national programme - experiences from Finland

Author

Pietinen Pirjo, Uusitalo Ulla, and Puska Pekka

Subjects
Economic growth, education.field_of_study, medicine.medical_specialty, Nutrition and Dietetics, business.industry, Community organization, Public health, Population, Public Health, Environmental and Occupational Health, Psychological intervention, Medicine (miscellaneous), Developing country, Non-communicable disease, medicine.disease, Health promotion, Environmental health, Global health, Medicine, business, education
Abstract

A global health transition is currently underway. The burden of non-communicable diseases (NCDs) is increasing rapidly in the developing world, very much as a result of changes in lifestyles. In addition to changes in tobacco use and physical activity, major changes are taking place in diets, contributing greatly to the growing epidemic of NCD. Thus, a huge global public health challenge is how to influence the trends in diet and nutrition for effective global NCD prevention.The health transition took place rapidly in Finland after World War II and mortality from cardiovascular disease (CVD) was exceptionally high. The North Karelia Project was launched in 1972 as a community-based, and later as a national, programme to influence diet and other lifestyles that are crucial in the prevention of CVD. The intervention had a strong theory base and it employed comprehensive strategies. Broad community organisation and the strong participation of people were the key elements. Evaluation has shown how the diet (particularly fat consumption) has changed and how these changes have led to a major reduction in population serum cholesterol and blood pressure levels. It has also shown how ischaemic heart disease mortality in a working-age population has declined by 73% in North Karelia and by 65% in the whole country from 1971 to 1995.Although Finland is an industrialised country, North Karelia was rural, of rather low socio-economic level and with many social problems in the 1970s and 1980s. The project was based on low-cost intervention activities, where people's participation and community organisations played a key role. Comprehensive interventions in the community were eventually supported by national activities – from expert guidelines and media activities to industry collaboration and policy. Similar principles for nutrition intervention programmes could be used in developing countries, obviously tailored to the local conditions. This paper discusses the experiences of the North Karelia Project in the light of needs from the less-industrialised countries and makes some general recommendations.

Published
2017

42. Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial

Author

Nucci, Anita M., Virtanen, Suvi M., Sorkio, Susa, Bärlund, Sonja, Cuthbertson, David, Uusitalo, Ulla, Lawson, Margaret L., Salonen, Marja, Berseth, Carol L., Ormisson, Anne, Lehtonen, Eveliina, Savilahti, Erkki, Becker, Dorothy J., Dupré, John, Krischer, Jeffrey P., Knip, Mikael, Åkerblom, Hans K., Mandrup-Poulsen, Thomas, Arjas, Elias, Läärä, Esa, and Lernmark, Åke

Subjects
endocrine system diseases, infant feeding, breastfeeding, type 1 diabetes, infant formula, breastfeeding duration, complementary feeding
Abstract

Differences in breastfeeding, other milk feeding and complementary feeding patterns were evaluated in infants at increased genetic risk with and without maternal type 1 diabetes (T1D). The Trial to Reduce IDDM in the Genetically at Risk is an international nutritional primary prevention double-blinded randomized trial to test whether weaning to extensively hydrolyzed vs. intact cow's milk protein formula will decrease the development of T1D-associated autoantibodies and T1D. Infant diet was prospectively assessed at two visits and seven telephone interviews between birth and 8 months. Countries were grouped into seven regions: Australia, Canada, Northern Europe, Southern Europe, Central Europe I, Central Europe II and the United States. Newborn infants with a first-degree relative with T1D and increased human leukocyte antigen-conferred susceptibility to T1D were recruited. A lower proportion of infants born to mothers with than without T1D were breastfed until 6 months of age in all regions (range, 51% to 60% vs. 70% to 80%). Complementary feeding patterns differed more by region than by maternal T1D. In Northern Europe, a higher proportion of infants consumed vegetables and fruits daily compared with other regions. Consumption of meat was more frequent in all European regions, whereas cereal consumption was most frequent in Southern Europe, Canada and the United States. Maternal T1D status was associated with breastfeeding and other milk feeding patterns similarly across regions but was unrelated to the introduction of complementary foods. Infant feeding patterns differed significantly among regions and were largely inconsistent with current recommended guidelines.

Published
2017

43. Urinary excretion of polyamines: importance of circadian rhythm, age, sex, menstrual cycle, weight, and creatinine excretion

Author

Poyhonen, Mikko J., Uusitalo, Ulla M., Kari, Aarno, Takala, Jukka A., Alakuijala, Liisa A., and Eloranta, Terho O.

Subjects
Polyamines -- Measurement, Polyamines -- Physiological aspects, Circadian rhythms -- Evaluation, Food/cooking/nutrition, Health
Abstract

Polyamines are small, positively-charged, carbon- and hydrogen-containing molecules that are arranged in chain-like structures. These molecules are important in cell growth and the production of nucleic acids and proteins, and are increased in rapidly growing tissue. Polyamines are excreted in the urine, and may serve as indicators of: disease, including cancer, liver disease, and lung disease; injury; and sepsis, or infection of the blood. The relationship of urinary excretion of polyamines to age, body weight, and the urinary excretion of creatinine (an indicator of muscle mass) was assessed. The excretion of the polyamines putrescine, spermidine, spermine, and N1- and N8-acetylspermidines in the urine was measured in 95 subjects. The presence of a circadian rhythm (24-hour pattern) of urinary excretion of polyamines was also assessed in eight subjects. N1- and N8-acetylspermidine were excreted in the urine in a circadian rhythm, with the greatest excretion occurring in the morning. Men excreted more spermidine, N8-acetylspermidine, and spermine than did women, whereas women excreted more putrescine than men. These differences in polyamine excretion between men and women were only partially due to differences in body weight or muscle mass. Polyamine excretion was not related to age or the menstrual cycle. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

44. Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study.

Author

Mattila, Markus, Erlund, Iris, Lee, Hye-Seung, Niinistö, Sari, Uusitalo, Ulla, Andrén Aronsson, Carin, Hummel, Sandra, Parikh, Hemang, Rich, Stephen S., Hagopian, William, Toppari, Jorma, Lernmark, Åke, Ziegler, Anette G., Rewers, Marian, Krischer, Jeffrey P., Norris, Jill M., and Virtanen, Suvi M.

Abstract

Aims/hypothesis: We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes. Methods: We used a risk set sampled nested case–control design within an ongoing international multicentre observational study: The Environmental Determinants of Diabetes in the Young (TEDDY). The TEDDY study followed children with increased genetic risk from birth to endpoints of islet autoantibodies (350 cases, 974 controls) and type 1 diabetes (102 cases, 282 controls) in six clinical centres. Control participants were matched for family history of type 1 diabetes, clinical centre and sex. Plasma ascorbic acid concentration was measured at ages 6 and 12 months and then annually up to age 6 years. SNPs in vitamin C transport genes were genotyped using the ImmunoChip custom microarray. Comparisons were adjusted for HLA genotypes and for background population stratification. Results: Childhood plasma ascorbic acid (mean ± SD 10.76 ± 3.54 mg/l in controls) was inversely associated with islet autoimmunity risk (adjusted OR 0.96 [95% CI 0.92, 0.99] per +1 mg/l), particularly islet autoimmunity, starting with insulin autoantibodies (OR 0.94 [95% CI 0.88, 0.99]), but not with type 1 diabetes risk (OR 0.93 [95% Cl 0.86, 1.02]). The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]). Conclusions/interpretation: Higher plasma ascorbic acid levels may protect against islet autoimmunity in children genetically at risk for type 1 diabetes. Further studies are warranted to confirm these findings. Data availability: The datasets generated and analysed during the current study will be made available in the NIDDK Central Repository at https://www.niddkrepository.org/studies/teddy. [ABSTRACT FROM AUTHOR]

Published
2020
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47. Association of Gluten Intake During the First 5 Years of Life With Incidence of Celiac Disease Autoimmunity and Celiac Disease Among Children at Increased Risk.

Author

Andrén Aronsson, Carin, Lee, Hye-Seung, Hård af Segerstad, Elin M., Uusitalo, Ulla, Yang, Jimin, Koletzko, Sibylle, Liu, Edwin, Kurppa, Kalle, Bingley, Polly J., Toppari, Jorma, Ziegler, Anette G., She, Jin-Xiong, Hagopian, William A., Rewers, Marian, Akolkar, Beena, Krischer, Jeffrey P., Virtanen, Suvi M., Norris, Jill M., Agardh, Daniel, and TEDDY Study Group

Subjects
GLUTEN, CELIAC disease, AUTOIMMUNITY, JUVENILE diseases, DISEASE risk factors
Abstract

Importance: High gluten intake during childhood may confer risk of celiac disease.Objectives: To investigate if the amount of gluten intake is associated with celiac disease autoimmunity and celiac disease in genetically at-risk children.Design, Setting, and Participants: The participants in The Environmental Determinants of Diabetes in the Young (TEDDY), a prospective observational birth cohort study designed to identify environmental triggers of type 1 diabetes and celiac disease, were followed up at 6 clinical centers in Finland, Germany, Sweden, and the United States. Between 2004 and 2010, 8676 newborns carrying HLA antigen genotypes associated with type 1 diabetes and celiac disease were enrolled. Screening for celiac disease with tissue transglutaminase autoantibodies was performed annually in 6757 children from the age of 2 years. Data on gluten intake were available in 6605 children (98%) by September 30, 2017.Exposures: Gluten intake was estimated from 3-day food records collected at ages 6, 9, and 12 months and biannually thereafter until the age of 5 years.Main Outcomes and Measures: The primary outcome was celiac disease autoimmunity, defined as positive tissue transglutaminase autoantibodies found in 2 consecutive serum samples. The secondary outcome was celiac disease confirmed by intestinal biopsy or persistently high tissue transglutaminase autoantibody levels.Results: Of the 6605 children (49% females; median follow-up: 9.0 years [interquartile range, 8.0-10.0 years]), 1216 (18%) developed celiac disease autoimmunity and 447 (7%) developed celiac disease. The incidence for both outcomes peaked at the age of 2 to 3 years. Daily gluten intake was associated with higher risk of celiac disease autoimmunity for every 1-g/d increase in gluten consumption (hazard ratio [HR], 1.30 [95% CI, 1.22-1.38]; absolute risk by the age of 3 years if the reference amount of gluten was consumed, 28.1%; absolute risk if gluten intake was 1-g/d higher than the reference amount, 34.2%; absolute risk difference, 6.1% [95% CI, 4.5%-7.7%]). Daily gluten intake was associated with higher risk of celiac disease for every 1-g/d increase in gluten consumption (HR, 1.50 [95% CI, 1.35-1.66]; absolute risk by age of 3 years if the reference amount of gluten was consumed, 20.7%; absolute risk if gluten intake was 1-g/d higher than the reference amount, 27.9%; absolute risk difference, 7.2% [95% CI, 6.1%-8.3%]).Conclusions and Relevance: Higher gluten intake during the first 5 years of life was associated with increased risk of celiac disease autoimmunity and celiac disease among genetically predisposed children. [ABSTRACT FROM AUTHOR]

Published
2019
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48. Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study.

Author

Silvis, Katherine, Aronsson, Carin A., Liu, Xiang, Uusitalo, Ulla, Yang, Jimin, Tamura, Roy, Lernmark, Åke, Rewers, Marian, Hagopian, William, She, Jin‐Xiong, Simell, Olli, Toppari, Jorma, Ziegler, Anette, Akolkar, Beena, Krischer, Jeffrey, Virtanen, Suvi M., and Norris, Jill M.

Subjects
AUTOANTIBODY analysis, TYPE 1 diabetes, CONFIDENCE intervals, DIETARY supplements, GLUTAMIC acid, INGESTION, INSULIN, ISLANDS of Langerhans, LONGITUDINAL method, MOTHERHOOD, OMEGA-3 fatty acids, PARENTING, SEX distribution, VITAMIN D, HLA-B27 antigen, FAMILY history (Medicine), ODDS ratio, GENOTYPES, PREGNANCY, GENETICS, DIABETES risk factors
Abstract

Objective: We investigated the association between maternal use of vitamin D and omega‐3 fatty acids (n‐3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n‐3 FAs were analyzed as continuous or binary variables. We applied time‐to‐event analysis to study the association between maternal supplement use and IA, adjusting for country, human leukocyte antigen‐DR‐DQ genotype, family history of type 1 diabetes and sex. Secondary outcomes included insulin autoantibodies (IAA) or glutamic acid decarboxylase (GADA) as the first appearing autoantibody. Results: As of February 2018, there were 747 (9.0%) children with IA. Vitamin D supplement intake during pregnancy (any vs none) was not associated with risk for IA (hazard ratio [HR] 1.11; 95% confidence interval [CI] 0.94, 1.31); neither was cumulative vitamin D supplement intake. Supplemental n‐3 FA intake was similarly not associated with IA risk (HR: 1.19, 95% CI 0.98, 1.45). Similar lack of association was observed for either IAA or GADA as the first appearing autoantibody. Conclusions: The TEDDY cohort showed no evidence of benefit regarding IA risk for vitamin D or n‐3 FA supplementation during pregnancy. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Milk feeding and first complementary foods during the first year of life in the TEDDY study.

Author

on behalf of the TEDDY Study Group, Riikonen, Anne, Virtanen, Suvi M., Norris, Jill M., Hadley, David, Uusitalo, Ulla, Yang, Jimin, Miller, Nicole, Koletzko, Sibylle, Andrén Aronsson, Carin, and Hummel, Sandra

Subjects
TYPE 1 diabetes, ARTIFICIAL feeding, BREASTFEEDING, COMPARATIVE studies, EXPERIMENTAL design, FISHER exact test, FOOD, GLUCANS, HEALTH status indicators, INFANT formulas, INFANTS, INFANT nutrition, INFANT weaning, LONGITUDINAL method, MEDICAL cooperation, MILK, MOTHERS, NUTRITIONAL requirements, POPULATION geography, RESEARCH, ENVIRONMENTAL exposure, PROBIOTICS, PREBIOTICS, DATA analysis software, DESCRIPTIVE statistics, MANN Whitney U Test, GENETICS, DIABETES risk factors
Abstract

Abstract: The aim was to describe milk feeding patterns and first weaning foods during the first year of life in a large prospective birth cohort of infants with increased genetic risk for Type 1 diabetes (T1D) recruited in 4 different countries: the United States, Finland, Germany, and Sweden. All enrolled children with dietary information (n = 8,673) were included in the analyses; 1,307 (15%) children who dropped out before the first birthday were excluded from some analyses. Supplementary milk feeding in the first 3 days of life was common in all the four countries, although the type of the supplementary milk differed by country and by maternal T1D. Donated human milk was commonly used only in Finland. In all the countries, the most common first supplementary food was cow's milk‐based infant formula, especially among offspring of mothers with T1D. The use of specific types of infant formulas differed notably by country: Extensively hydrolysed formulas were most used in Finland, partially hydrolysed ones in the United States and in Germany, and soy formulas only in the United States. Infant formulas commonly included probiotics, prebiotics, and starches. During the first year of life, most of the infants received conventional cow's milk. Overall, milk feeding during the first 3 days of life and thereafter until the first birthday differed markedly by maternal T1D status and across countries. These descriptive data may be useful in understanding early infant feeding practices and in planning potential interventions, which affect infant feeding. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Effects of Gluten Intake on Risk of Celiac Disease: A Case-Control Study on a Swedish Birth Cohort

Author

Andrén Aronsson, Carin, primary, Lee, Hye-Seung, additional, Koletzko, Sibylle, additional, Uusitalo, Ulla, additional, Yang, Jimin, additional, Virtanen, Suvi M., additional, Liu, Edwin, additional, Lernmark, Åke, additional, Norris, Jill M., additional, Agardh, Daniel, additional, Rewers, Marian, additional, Bautista, Kimberly, additional, Baxter, Judith, additional, Bedoy, Ruth, additional, Felipe-Morales, Daniel, additional, Frohnert, Brigitte I., additional, Gesualdo, Patricia, additional, Hoffman, Michelle, additional, Karban, Rachel, additional, Norris, Jill, additional, Samper-Imaz, Adela, additional, Steck, Andrea, additional, Waugh, Kathleen, additional, Wright, Hali, additional, She, Jin-Xiong, additional, Schatz, Desmond, additional, Hopkins, Diane, additional, Steed, Leigh, additional, Thomas, Jamie, additional, Adams, Janey, additional, Silvis, Katherine, additional, Haller, Michael, additional, Gardiner, Melissa, additional, McIndoe, Richard, additional, Sharma, Ashok, additional, Williams, Joshua, additional, Foghis, Gabriela, additional, Anderson, Stephen W., additional, Robinson, Richard, additional, Ziegler, Anette G., additional, Beyerlein, Andreas, additional, Bonifacio, Ezio, additional, Hummel, Michael, additional, Hummel, Sandra, additional, Foterek, Kristina, additional, Kersting, Mathilde, additional, Knopff, Annette, additional, Peplow, Claudia, additional, Roth, Roswith, additional, Stock, Joanna, additional, Strauss, Elisabeth, additional, Warncke, Katharina, additional, Winkler, Christiane, additional, Toppari, Jorma, additional, Simell, Olli G., additional, Adamsson, Annika, additional, Hyöty, Heikki, additional, Ilonen, Jorma, additional, Jokipuu, Sanna, additional, Kallio, Tiina, additional, Kähönen, Miia, additional, Knip, Mikael, additional, Koivu, Annika, additional, Koreasalo, Mirva, additional, Kurppa, Kalle, additional, Lönnrot, Maria, additional, Mäntymäki, Elina, additional, Multasuo, Katja, additional, Mykkänen, Juha, additional, Niininen, Tiina, additional, Nyblom, Mia, additional, Rajala, Petra, additional, Rautanen, Jenna, additional, Riikonen, Anne, additional, Romo, Minna, additional, Simell, Satu, additional, Simell, Tuula, additional, Simell, Ville, additional, Sjöberg, Maija, additional, Stenius, Aino, additional, Särmä, Maria, additional, Vainionpää, Sini, additional, Varjonen, Eeva, additional, Veijola, Riitta, additional, Vähä-Mäkilä, Mari, additional, Åkerlund, Mari, additional, Aronsson, Carin Andrén, additional, Ask, Maria, additional, Bremer, Jenny, additional, Carlsson, Ulla-Marie, additional, Cilio, Corrado, additional, Ericson-Hallström, Emelie, additional, Fransson, Lina, additional, Gard, Thomas, additional, Gerardsson, Joanna, additional, Bennet, Rasmus, additional, Hansen, Monica, additional, Hansson, Gertie, additional, Harmby, Cecilia, additional, Hyberg, Susanne, additional, Johansen, Fredrik, additional, Jonasdottir, Berglind, additional, Larsson, Helena Elding, additional, Forss, Sigrid Lenrick, additional, Lundgren, Markus, additional, Månsson-Martinez, Maria, additional, Markan, Maria, additional, Melin, Jessica, additional, Mestan, Zeliha, additional, Rahmati, Kobra, additional, Ramelius, Anita, additional, Rosenquist, Anna, additional, Salami, Falastin, additional, Sibthorpe, Sara, additional, Sjöberg, Birgitta, additional, Swartling, Ulrica, additional, Amboh, Evelyn Tekum, additional, Trulsson, Erika, additional, Törn, Carina, additional, Wallin, Anne, additional, Wimar, Åsa, additional, Åberg, Sofie, additional, Hagopian, William A., additional, Killian, Michael, additional, Crouch, Claire Cowen, additional, Skidmore, Jennifer, additional, Ayres, Stephen, additional, Dunson, Kayleen, additional, Hervey, Rachel, additional, Johnson, Corbin, additional, Lyons, Rachel, additional, Meyer, Arlene, additional, Mulenga, Denise, additional, Scott, Elizabeth, additional, Stabbert, Joshua, additional, Tarr, Alexander, additional, Uland, Morgan, additional, Willis, John, additional, Becker, Dorothy, additional, Franciscus, Margaret, additional, Smith, MaryEllen Dalmagro-Elias, additional, Daftary, Ashi, additional, Klein, Mary Beth, additional, Yates, Chrystal, additional, Krischer, Jeffrey P., additional, Abbondondolo, Michael, additional, Austin-Gonzalez, Sarah, additional, Baethke, Sandra, additional, Brown, Rasheedah, additional, Burkhardt, Brant, additional, Butterworth, Martha, additional, Clasen, Joanna, additional, Cuthbertson, David, additional, Eberhard, Christopher, additional, Fiske, Steven, additional, Garcia, Dena, additional, Garmeson, Jennifer, additional, Gowda, Veena, additional, Heyman, Kathleen, additional, Laras, Francisco Perez, additional, Liu, Shu, additional, Liu, Xiang, additional, Lynch, Kristian, additional, Malloy, Jamie, additional, McCarthy, Cristina, additional, McLeod, Wendy, additional, Meulemans, Steven, additional, Shaffer, Chris, additional, Smith, Laura, additional, Smith, Susan, additional, Sulman, Noah, additional, Tamura, Roy, additional, Vehik, Kendra, additional, Vijayakandipan, Ponni, additional, Wood, Keith, additional, Ballard, Lori, additional, Hadley, David, additional, Akolkar, Beena, additional, Bourcier, Kasia, additional, Briese, Thomas, additional, Johnson, Suzanne Bennett, additional, and Triplett, Eric, additional

Published
2016
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