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Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study.
- Source :
- Diabetes Care; May2023, Vol. 46 Issue 5, p1014-1018, 5p, 1 Color Photograph, 3 Charts, 1 Graph
- Publication Year :
- 2023
-
Abstract
- OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron. RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake. CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes. [ABSTRACT FROM AUTHOR]
- Subjects :
- TYPE 1 diabetes
IRON overload
FOOD consumption
IRON
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 46
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 163418847
- Full Text :
- https://doi.org/10.2337/dc22-1359