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2. Timing of HPV16-E6 antibody seroconversion before OPSCC: findings from the HPVC3 consortium

Author

Kreimer, A.R., Ferreiro-Iglesias, A., Nygard, M., Bender, N., Schroeder, L., Hildesheim, A., Robbins, H.A., Pawlita, M., Langseth, H., Schlecht, N.F., Tinker, L.F., Agalliu, I., Smoller, S.W., Ness-Jensen, E., Hveem, K., D’Souza, G., Visvanathan, K., May, B., Ursin, G., Weiderpass, E., Giles, G.G., Milne, R.L., Cai, Q., Blot, W.J., Zheng, W., Weinstein, S.J., Albanes, D., Brenner, N., Hoffman-Bolton, J., Kaaks, R., Barricarte, A., Tjønneland, A., Sacerdote, C., Trichopoulou, A., Vermeulen, R.C.H., Huang, W.-Y., Freedman, N.D., Brennan, P., Waterboer, T., and Johansson, M.

Published
2019
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3. The association of polymorphisms in hormone metabolism pathway genes, menopausal hormone therapy, and breast cancer risk: A nested case-control study in the California Teachers Study cohort

Author

Lee, E, Schumacher, F, Lewinger, JP, Neuhausen, SL, Anton-Culver, H, Horn-Ross, PL, Henderson, KD, Ziogas, A, Van Den Berg, D, Bernstein, L, and Ursin, G

Abstract

Introduction: The female sex steroids estrogen and progesterone are important in breast cancer etiology. It therefore seems plausible that variation in genes involved in metabolism of these hormones may affect breast cancer risk, and that these associations may vary depending on menopausal status and use of hormone therapy.Methods: We conducted a nested case-control study of breast cancer in the California Teachers Study cohort. We analyzed 317 tagging single nucleotide polymorphisms (SNPs) in 24 hormone pathway genes in 2746 non-Hispanic white women: 1351 cases and 1395 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by fitting conditional logistic regression models using all women or subgroups of women defined by menopausal status and hormone therapy use. P values were adjusted for multiple correlated tests (PACT).Results: The strongest associations were observed for SNPs in SLCO1B1, a solute carrier organic anion transporter gene, which transports estradiol-17β-glucuronide and estrone-3-sulfate from the blood into hepatocytes. Ten of 38 tagging SNPs of SLCO1B1 showed significant associations with postmenopausal breast cancer risk; 5 SNPs (rs11045777, rs11045773, rs16923519, rs4149057, rs11045884) remained statistically significant after adjusting for multiple testing within this gene (PACT= 0.019-0.046). In postmenopausal women who were using combined estrogen-progestin therapy (EPT) at cohort enrollment, the OR of breast cancer was 2.31 (95% CI = 1.47-3.62) per minor allele of rs4149013 in SLCO1B1 (P = 0.0003; within-gene PACT= 0.002; overall PACT= 0.023). SNPs in other hormone pathway genes evaluated in this study were not associated with breast cancer risk in premenopausal or postmenopausal women.Conclusions: We found evidence that genetic variation in SLCO1B1 is associated with breast cancer risk in postmenopausal women, particularly among those using EPT. © 2011 Lee et al.; licensee BioMed Central Ltd.

Published
2011

4. Hypertension, antihypertensive medication use, and breast cancer risk in the California teachers study cohort

Author

Largent, JA, Bernstein, L, Horn-Ross, PL, Marshall, SF, Neuhausen, S, Reynolds, P, Ursin, G, Zell, JA, Ziogas, A, and Anton-Culver, H

Abstract

Background: We investigated the association between hypertension, antihypertensive (AH) medication use, and breast cancer in a large prospective study, the California Teachers Study (CTS). Methods: Information on history of hypertension and lifetime regular use of AH medications was collected from 114,549 women in 1995-1996. Among them, 4,151 invasive breast cancers were diagnosed between 1995 and 2006. Additional information on AH use was collected from 73,742 women in 2000-2001, and 1,714 of these women were subsequently diagnosed with breast cancer. Cox proportional hazards regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) for breast cancer. Results: Use of AH medication for ≥5 years, when compared with no use, was associated with a modest increased risk of invasive breast cancer (RR = 1.18, 95%CI 1.02-1.36). This increased risk appeared to be confined to estrogen receptor (ER)-positive tumors (RR = 1.21, 95%CI 1.03-1.43) and pre-/peri-menopausal women (RR = 1.58, 95%CI 1.11-2.25). Conclusions: Increased risk of invasive breast cancer was observed for long-term (≥5 years) AH use, and this appeared to be confined to ER + breast cancer and younger women. © 2010 The Author(s).

Published
2010

5. Family history of haematopoietic malignancies and non-Hodgkin's lymphoma risk in the California Teachers Study

Author

Lu, Y, Sullivan-Halley, J, Cozen, W, Chang, ET, Henderson, K, Ma, H, Deapen, D, Clarke, C, Reynolds, P, Neuhausen, SL, Anton-Culver, H, Ursin, G, West, D, and Bernstein, L

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Oncology and Carcinogenesis, Rare Diseases, Hematology, Lymphoma, Cancer, Adult, Aged, Aged, 80 and over, California, Female, Genetic Predisposition to Disease, Hematologic Neoplasms, Humans, Middle Aged, Prospective Studies, Surveys and Questionnaires, non-Hodgkin's lymphoma, family history, haematopoietic malignancy, lymphoma, leukaemia, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Family history of haematopoietic malignancies appears to be a risk factor for non-Hodgkin's lymphoma (NHL), but whether risk varies by family member's gender is unclear. Among 121 216 women participating in the prospective California Teachers Study, NHL risk varied by type of haematopoietic malignancy and gender of the relative.

Published
2009

6. International incidence of childhood cancer, 2001–10: a population-based registry study

Author

Bouzbid, S, Hamdi-Cherif, M, Hablas, A, Chirpaz, E, Buziba, N, Chesumbai, GC, Manraj, SS, Reynders, D, Wabinga, HR, Chokunonga, E, Moreno, F, Lima, CA, Asturian Laporte, C, de Oliveira, JC, de Aquino, JA Pontes, Gallagher, SM Vargas, Uribe, CJ, Bravo, LE, Yepez Chamorro, MC, Torres Alvarado, G, Galán Alvarez, YH, Martinez Reyes, FC, Castillo Calvas, JC, Mendoza Alava, M, Cueva Ayala, P, Hanchard, B, Fajardo-Gutiérrez, A, Zavala Zegarra, DE, Barrios, E, Nikiforuk, C, Woods, R, Turner, D, MacIntyre, M, Corriveau, A, Navaneelan, T, Bertrand, C, Stuart-Panko, H, Wilson, RJ, Kosary, C, Shen, X, Brockhouse, J, Yee, GA, Mitchell, TC, Snipes, K, West, D, Rao, C, Bolick, S, Rycroft, RK, Mueller, L, Zheng, Y, Dosch, K, Brown, H, Vargas, A, Levin, GM, Bayakly, R, Johnson, C, Shen, T, Ruppert, L, Lynch, CF, Lai, SM, Tucker, TC, Wu, XC, Schwenn, M, Stern, K, Gershman, S, Copeland, G, Bushhouse, S, Rogers, DB, Jackson Thompson, J, Lemons, D, Frederick, S, Harris, JA, Riddle, B, Stroup, A, Wiggins, C, Schymura, MJ, Giljahn, LK, Sheikh, A, Schubert, S, Aldinger, W, Fulton, JP, Whiteside, M, Nogueira, L, Sweeney, C, Johnson, A, Martin, J, Farley, S, Harrelson, D, Malicki, R, Espinoza, JR, Hernandez, BY, Abulfateh, N, Wang, N, Ngan, RKC, Lingegowda, KB, Swaminathan, R, Koyande, SS, Silverman, B, Ozasa, K, Kanemura, S, Soda, M, Miyashiro, I, Shibata, A, Nimri, O, Won, YJ, Kim, CH, Hong, NS, Nam, HS, Kweon, S, Kim, WC, Huh, JS, Jung, KW, Yoo, CI, Elbasmy, A, Laudico, AV, Lumague, MR, AlMutlag, H, Buasom, R, Srisukho, S, Tanabodee, J, Wiangnon, S, Pongnikorn, D, Sriplung, H, Dirican, O, Eser, S, Le Hoang, M, Hackl, M, Zborovskaya, A, Dimitrova, N, Valerianova, Z, Sekerija, M, Pavlou, P, Dušek, M, Mägi, M, Clavel, J, Lacour, B, Guizard, AV, Bouvier, V, Troussard, X, Woronoff, AS, Tretarre, B, Colonna, M, Molinié, F, Bara, S, Velten, M, Marrer, E, Ganry, O, Grosclaude, P, Kaatsch, P, Zeissig, SR, Holleczek, B, Katalinic, A, Jakab, Z, Birgisson, H, Walsh, PM, Mangone, L, Merletti, F, Magoni, M, Ferretti, S, Serraino, D, Spagnoli, G, Fusco, M, Michiara, M, Tumino, R, Falcini, F, Sensi, F, Tisano, F, Piffer, S, Stracci, F, Tagliabue, G, Smailyte, G, Agius, D, Visser, O, Ursin, G, Didkowska, J, Trojanowski, M, Wojciechowska, U, Forjaz de Lacerda, G, Silva, MA, Laranja Pontes, J, da Costa Miranda, A, Kaiserova, E, Primic Žakelj, M, Peris-Bonet, R, Vicente Raneda, ML, Almar Marqués, E, Quirós Garcia, JR, Ramos Monserrat, M, Errezola Saizar, M, Alemán Herrera, A, Díaz García, JM, Marcos-Gragera, R, Sanchez-Perez, MJ, Ardanaz Aicua, E, Galceran, J, Klint, A, Kuehni, CE, Bouchardy, C, Levi, F, Bordoni, A, Konzelmann, I, Rohrmann, S, Stiller, CA, Gavin, AT, Brewster, DH, Phung, H, Rushton, S, Guthridge, S, Aitken, J, D'Onise, K, Venn, A, Farrugian, H, Threlfall, TJ, Laumond, S, Yen Kai Sun, L, Hendrix, J, Ballantine, K, Colombet, M, Dolya, A, Masuyer, E, Steliarova-Foucher, E, Steliarova-Foucher, Eva, Colombet, Murielle, Ries, Lynn A G, Moreno, Florencia, Dolya, Anastasia, Bray, Freddie, Hesseling, Peter, Shin, Hee Young, and Stiller, Charles A

Published
2017
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10. Cohort Profile: The Ovarian Cancer Cohort Consortium (OC3).

Author

Townsend M.K., Trabert B., Fortner R.T., Arslan A.A., Buring J.E., Carter B.D., Giles G.G., Irvin S.R., Jones M.E., Kaaks R., Kirsh V.A., Knutsen S.F., Koh W.-P., Lacey J.V., Langseth H., Larsson S.C., Lee I.-M., Martinez M.E., Merritt M.A., Milne R.L., O'Brien K.M., Orlich M.J., Palmer J.R., Patel A.V., Peters U., Poynter J.N., Robien K., Rohan T.E., Rosenberg L., Sandin S., Sandler D.P., Schouten L.J., Setiawan V.W., Swerdlow A.J., Ursin G., van den Brandt P.A., Visvanathan K., Weiderpass E., Wolk A., Yuan J.-M., Zeleniuch-Jacquotte A., Tworoger S.S., Wentzensen N., Townsend M.K., Trabert B., Fortner R.T., Arslan A.A., Buring J.E., Carter B.D., Giles G.G., Irvin S.R., Jones M.E., Kaaks R., Kirsh V.A., Knutsen S.F., Koh W.-P., Lacey J.V., Langseth H., Larsson S.C., Lee I.-M., Martinez M.E., Merritt M.A., Milne R.L., O'Brien K.M., Orlich M.J., Palmer J.R., Patel A.V., Peters U., Poynter J.N., Robien K., Rohan T.E., Rosenberg L., Sandin S., Sandler D.P., Schouten L.J., Setiawan V.W., Swerdlow A.J., Ursin G., van den Brandt P.A., Visvanathan K., Weiderpass E., Wolk A., Yuan J.-M., Zeleniuch-Jacquotte A., Tworoger S.S., and Wentzensen N.

Published
2021

13. Timing of HPV16-E6 antibody seroconversion before OPSCC: findings from the HPVC3 consortium.

Author

Johansson M., Vermeulen R.C.H., Huang W.-Y., Freedman N.D., Brennan P., Waterboer T., Kreimer A.R., Ferreiro-Iglesias A., Nygard M., Bender N., Schroeder L., Hildesheim A., Robbins H.A., Pawlita M., Langseth H., Schlecht N.F., Tinker L.F., Agalliu I., Smoller S.W., Ness-Jensen E., Hveem K., D'Souza G., Visvanathan K., May B., Ursin G., Weiderpass E., Giles G.G., Milne R.L., Cai Q., Blot W.J., Zheng W., Weinstein S.J., Albanes D., Brenner N., Hoffman-Bolton J., Kaaks R., Barricarte A., Tjonneland A., Sacerdote C., Trichopoulou A., Johansson M., Vermeulen R.C.H., Huang W.-Y., Freedman N.D., Brennan P., Waterboer T., Kreimer A.R., Ferreiro-Iglesias A., Nygard M., Bender N., Schroeder L., Hildesheim A., Robbins H.A., Pawlita M., Langseth H., Schlecht N.F., Tinker L.F., Agalliu I., Smoller S.W., Ness-Jensen E., Hveem K., D'Souza G., Visvanathan K., May B., Ursin G., Weiderpass E., Giles G.G., Milne R.L., Cai Q., Blot W.J., Zheng W., Weinstein S.J., Albanes D., Brenner N., Hoffman-Bolton J., Kaaks R., Barricarte A., Tjonneland A., Sacerdote C., and Trichopoulou A.

Abstract

Background: Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis in the majority of HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), but the timing of seroconversion is unknown. Patients and Methods: We formed the HPV Cancer Cohort Consortium which comprises nine population cohorts from Europe, North America and Australia. In total, 743 incident OPSCC cases and 5814 controls provided at least one pre-diagnostic blood sample, including 111 cases with multiple samples. Median time between first blood collection and OPSCC diagnosis was 11.4 years (IQR = 6-11 years, range = 0-40 years). Antibodies against HPV16-E6 were measured by multiplex serology (GST fusion protein based Luminex assay). Result(s): HPV16-E6 seropositivity was present in 0.4% of controls (22/5814; 95% CI 0.2% to 0.6%) and 26.2% (195/743; 95% CI 23.1% to 29.6%) of OPSCC cases. HPV16-E6 seropositivity increased the odds of OPSCC 98.2-fold (95% CI 62.1-155.4) in whites and 17.2-fold (95% CI 1.7-170.5) in blacks. Seropositivity in cases was more frequent in recent calendar periods, ranging from 21.9% pre-1996 to 68.4% in 2005 onwards, in those with blood collection near diagnosis (lead time <5 years). HPV16-E6 seropositivity increased with lead time: 0.0%, 13.5%, 23.7%, and 38.9% with lead times of >30 years (N = 24), 20-30 years (N = 148), 10-20 years (N = 228), and <10 years (N = 301 cases) (p-trend < 0.001). Of the 47 HPV16-E6 seropositive cases with serially-collected blood samples, 17 cases seroconverted during follow-up, with timing ranging from 6 to 28 years before diagnosis. For the remaining 30 cases, robust seropositivity was observed up to 25 years before diagnosis. Conclusion(s): The immune response to HPV16-driven tumorigenesis is most often detectable several decades before OPSCC diagnosis. HPV16-E6 seropositive individuals face increased risk of OPSCC over several decades.Copyright © 2019 THE AUTHORS

Published
2020

14. Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women

Author

Schoemaker, MJ, Nichols, HB, Wright, LB, Brook, MN, Jones, ME, O'Brien, KM, Adami, H-O, Baglietto, L, Bernstein, L, Bertrand, KA, Boutron-Ruault, M-C, Chen, Y, Connor, AE, Dossus, L, Eliassen, AH, Giles, GG, Gram, IT, Hankinson, SE, Kaaks, R, Key, TJ, Kirsh, VA, Kitahara, CM, Larsson, SC, Linet, M, Ma, H, Milne, RL, Ozasa, K, Palmer, JR, Riboli, E, Rohan, TE, Sacerdote, C, Sadakane, A, Sund, M, Tamimi, RM, Trichopoulou, A, Ursin, G, Visvanathan, K, Weiderpass, E, Willett, WC, Wolk, A, Zeleniuch-Jacquotte, A, Sandler, DP, Swerdlow, AJ, Schoemaker, MJ, Nichols, HB, Wright, LB, Brook, MN, Jones, ME, O'Brien, KM, Adami, H-O, Baglietto, L, Bernstein, L, Bertrand, KA, Boutron-Ruault, M-C, Chen, Y, Connor, AE, Dossus, L, Eliassen, AH, Giles, GG, Gram, IT, Hankinson, SE, Kaaks, R, Key, TJ, Kirsh, VA, Kitahara, CM, Larsson, SC, Linet, M, Ma, H, Milne, RL, Ozasa, K, Palmer, JR, Riboli, E, Rohan, TE, Sacerdote, C, Sadakane, A, Sund, M, Tamimi, RM, Trichopoulou, A, Ursin, G, Visvanathan, K, Weiderpass, E, Willett, WC, Wolk, A, Zeleniuch-Jacquotte, A, Sandler, DP, and Swerdlow, AJ

Abstract

Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.

Published
2020

15. COLONOSCOPY QUALITY AFTER INTENSIVE TRAINING OF INEXPERIENCED ENDOSCOPISTS IN A NORWEGIAN SCREENING TRIAL FOR COLORECTAL CANCER

Author

Schult, AL, additional, Randel, KR, additional, Botteri, E, additional, Hoff, G, additional, Bretthauer, M, additional, Ursin, G, additional, Natvig, E, additional, Jørgensen, A, additional, Sandvei, P, additional, Ek Olsen, MK, additional, Frigstad, SO, additional, Darre-Næss, O, additional, Norvard, ER, additional, Kørner, H, additional, Wibe, A, additional, de Lange, T, additional, and Holme, Ø, additional

Published
2020
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16. Data must be shared-also with researchers outside of Europe

Author

Ursin, G., Stenbeck, M., Chang-Claude, J., Gunter, M., Kaaks, R., Kampman, E., Lambe, M., Leeuwen, F van, Magnusson, P., Malila, N., Nilbert, M.C., Romundstad, P.R., Roosli, M., Ryel, A.L., Dos-Santos-Silva, I., Storm, H.H., Swerdlow, A., Vineis, P., Knudsen, G.P.S., Ursin, G., Stenbeck, M., Chang-Claude, J., Gunter, M., Kaaks, R., Kampman, E., Lambe, M., Leeuwen, F van, Magnusson, P., Malila, N., Nilbert, M.C., Romundstad, P.R., Roosli, M., Ryel, A.L., Dos-Santos-Silva, I., Storm, H.H., Swerdlow, A., Vineis, P., and Knudsen, G.P.S.

Abstract

Contains fulltext : 215407.pdf (publisher's version ) (Closed access)

Published
2019

17. Timing of HPV16-E6 antibody seroconversion before OPSCC: Findings from the HPVC3 consortium.

Author

Waterboer T., Vermeulen R.C.H., Huang W.-Y., Freedman N.D., Brennan P., Johansson M., Kreimer A.R., Ferreiro-Iglesias A., Nygard M., Bender N., Schroeder L., Hildesheim A., Robbins H.A., Pawlita M., Langseth H., Schlecht N.F., Tinker L.F., Agalliu I., Smoller S.W., Ness-Jensen E., Hveem K., D'Souza G., Visvanathan K., May B., Ursin G., Weiderpass E., Giles G.G., Milne R.L., Cai Q., Blot W.J., Zheng W., Weinstein S.J., Albanes D., Brenner N., Hoffman-Bolton J., Kaaks R., Barricarte A., Tjonneland A., Sacerdote C., Trichopoulou A., Waterboer T., Vermeulen R.C.H., Huang W.-Y., Freedman N.D., Brennan P., Johansson M., Kreimer A.R., Ferreiro-Iglesias A., Nygard M., Bender N., Schroeder L., Hildesheim A., Robbins H.A., Pawlita M., Langseth H., Schlecht N.F., Tinker L.F., Agalliu I., Smoller S.W., Ness-Jensen E., Hveem K., D'Souza G., Visvanathan K., May B., Ursin G., Weiderpass E., Giles G.G., Milne R.L., Cai Q., Blot W.J., Zheng W., Weinstein S.J., Albanes D., Brenner N., Hoffman-Bolton J., Kaaks R., Barricarte A., Tjonneland A., Sacerdote C., and Trichopoulou A.

Abstract

Background: Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis in the majority of HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), but the timing of seroconversion is unknown. Patients and Methods: We formed the HPV Cancer Cohort Consortium which comprises nine population cohorts from Europe, North America and Australia. In total, 743 incident OPSCC cases and 5814 controls provided at least one pre-diagnostic blood sample, including 111 cases with multiple samples. Median time between first blood collection and OPSCC diagnosis was 11.4 years (IQR = 6-11 years, range = 0-40 years). Antibodies against HPV16-E6 were measured by multiplex serology (GST fusion protein based Luminex assay). Result(s): HPV16-E6 seropositivity was present in 0.4% of controls (22/5814; 95% CI 0.2% to 0.6%) and 26.2% (195/743; 95% CI 23.1% to 29.6%) of OPSCC cases. HPV16-E6 seropositivity increased the odds of OPSCC 98.2-fold (95% CI 62.1-155.4) in whites and 17.2-fold (95% CI 1.7-170.5) in blacks. Seropositivity in cases was more frequent in recent calendar periods, ranging from 21.9% pre-1996 to 68.4% in 2005 onwards, in those with blood collection near diagnosis (lead time <5 years). HPV16-E6 seropositivity increased with lead time: 0.0%, 13.5%, 23.7%, and 38.9% with lead times of >30 years (N = 24), 20-30 years (N = 148), 10-20 years (N = 228), and <10 years (N = 301 cases) (p-trend < 0.001). Of the 47 HPV16-E6 seropositive cases with serially-collected blood samples, 17 cases seroconverted during follow-up, with timing ranging from 6 to 28 years before diagnosis. For the remaining 30 cases, robust seropositivity was observed up to 25 years before diagnosis. Conclusion(s): The immune response to HPV16-driven tumorigenesis is most often detectable several decades before OPSCC diagnosis. HPV16-E6 seropositive individuals face increased risk of OPSCC over several decades.Copyright © 2019 The Author(s). Published by Oxford Univers

Published
2019

18. Sharing data safely while preserving privacy

Author

Ursin, G., Malila, N., Chang-Claude, J., Gunter, M., Kaaks, R., Kampman, E., Lambe, M., Leeuwen, F van, Magnusson, P., Nilbert, M.C., Romundstad, P.R., Roosli, M., Ryel, A.L., Dos-Santos-Silva, I., Stenbeck, M., Storm, H.H., Swerdlow, A., Vineis, P., Knudsen, G.P.S., Ursin, G., Malila, N., Chang-Claude, J., Gunter, M., Kaaks, R., Kampman, E., Lambe, M., Leeuwen, F van, Magnusson, P., Nilbert, M.C., Romundstad, P.R., Roosli, M., Ryel, A.L., Dos-Santos-Silva, I., Stenbeck, M., Storm, H.H., Swerdlow, A., Vineis, P., and Knudsen, G.P.S.

Abstract

Contains fulltext : 215524.pdf (publisher's version ) (Closed access)

Published
2019

19. Timing of HPV16-E6 antibody seroconversion before OPSCC: findings from the HPVC3 consortium

Author

Kreimer, AR, Ferreiro-Iglesias, A, Nygard, M, Bender, N, Schroeder, L, Hildesheim, A, Robbins, HA, Pawlita, M, Langseth, H, Schlecht, NF, Tinker, LF, Agalliu, I, Smoller, SW, Ness-Jensen, E, Hveem, K, D'Souza, G, Visvanathan, K, May, B, Ursin, G, Weiderpass, E, Giles, GG, Milne, RL, Cai, Q, Blot, WJ, Zheng, W, Weinstein, SJ, Albanes, D, Brenner, N, Hoffman-Bolton, J, Kaaks, R, Barricarte, A, Tjonneland, A, Sacerdote, C, Trichopoulou, A, Vermeulen, RCH, Huang, W-Y, Freedman, ND, Brennan, P, Waterboer, T, Johansson, M, Kreimer, AR, Ferreiro-Iglesias, A, Nygard, M, Bender, N, Schroeder, L, Hildesheim, A, Robbins, HA, Pawlita, M, Langseth, H, Schlecht, NF, Tinker, LF, Agalliu, I, Smoller, SW, Ness-Jensen, E, Hveem, K, D'Souza, G, Visvanathan, K, May, B, Ursin, G, Weiderpass, E, Giles, GG, Milne, RL, Cai, Q, Blot, WJ, Zheng, W, Weinstein, SJ, Albanes, D, Brenner, N, Hoffman-Bolton, J, Kaaks, R, Barricarte, A, Tjonneland, A, Sacerdote, C, Trichopoulou, A, Vermeulen, RCH, Huang, W-Y, Freedman, ND, Brennan, P, Waterboer, T, and Johansson, M

Abstract

BACKGROUND: Human papillomavirus type 16 (HPV16)-E6 antibodies are detectable in peripheral blood before diagnosis in the majority of HPV16-driven oropharyngeal squamous cell carcinoma (OPSCC), but the timing of seroconversion is unknown. PATIENTS AND METHODS: We formed the HPV Cancer Cohort Consortium which comprises nine population cohorts from Europe, North America and Australia. In total, 743 incident OPSCC cases and 5814 controls provided at least one pre-diagnostic blood sample, including 111 cases with multiple samples. Median time between first blood collection and OPSCC diagnosis was 11.4 years (IQR = 6-11 years, range = 0-40 years). Antibodies against HPV16-E6 were measured by multiplex serology (GST fusion protein based Luminex assay). RESULTS: HPV16-E6 seropositivity was present in 0.4% of controls (22/5814; 95% CI 0.2% to 0.6%) and 26.2% (195/743; 95% CI 23.1% to 29.6%) of OPSCC cases. HPV16-E6 seropositivity increased the odds of OPSCC 98.2-fold (95% CI 62.1-155.4) in whites and 17.2-fold (95% CI 1.7-170.5) in blacks. Seropositivity in cases was more frequent in recent calendar periods, ranging from 21.9% pre-1996 to 68.4% in 2005 onwards, in those with blood collection near diagnosis (lead time <5 years). HPV16-E6 seropositivity increased with lead time: 0.0%, 13.5%, 23.7%, and 38.9% with lead times of >30 years (N = 24), 20-30 years (N = 148), 10-20 years (N = 228), and <10 years (N = 301 cases) (p-trend < 0.001). Of the 47 HPV16-E6 seropositive cases with serially-collected blood samples, 17 cases seroconverted during follow-up, with timing ranging from 6 to 28 years before diagnosis. For the remaining 30 cases, robust seropositivity was observed up to 25 years before diagnosis. CONCLUSIONS: The immune response to HPV16-driven tumorigenesis is most often detectable several decades before OPSCC diagnosis. HPV16-E6 seropositive individuals face increased risk of OPSCC over several decades.

Published
2019

20. Measurement challenge: protocol for international case-control comparison of mammographic measures that predict breast cancer risk

Author

Dench, E, Bond-Smith, D, Darcey, E, Lee, G, Aung, YK, Chan, A, Cuzick, J, Ding, ZY, Evans, CF, Harvey, J, Highnam, R, Hsieh, M-K, Kontos, D, Li, S, Mariapun, S, Nickson, C, Nguyen, TL, Pertuz, S, Procopio, P, Rajaram, N, Repich, K, Tan, M, Teo, S-H, Trinh, NH, Ursin, G, Wang, C, dos-Santos-Silva, I, McCormack, V, Nielsen, M, Shepherd, J, Hopper, JL, Stone, J, Dench, E, Bond-Smith, D, Darcey, E, Lee, G, Aung, YK, Chan, A, Cuzick, J, Ding, ZY, Evans, CF, Harvey, J, Highnam, R, Hsieh, M-K, Kontos, D, Li, S, Mariapun, S, Nickson, C, Nguyen, TL, Pertuz, S, Procopio, P, Rajaram, N, Repich, K, Tan, M, Teo, S-H, Trinh, NH, Ursin, G, Wang, C, dos-Santos-Silva, I, McCormack, V, Nielsen, M, Shepherd, J, Hopper, JL, and Stone, J

Abstract

INTRODUCTION: For women of the same age and body mass index, increased mammographic density is one of the strongest predictors of breast cancer risk. There are multiple methods of measuring mammographic density and other features in a mammogram that could potentially be used in a screening setting to identify and target women at high risk of developing breast cancer. However, it is unclear which measurement method provides the strongest predictor of breast cancer risk. METHODS AND ANALYSIS: The measurement challenge has been established as an international resource to offer a common set of anonymised mammogram images for measurement and analysis. To date, full field digital mammogram images and core data from 1650 cases and 1929 controls from five countries have been collated. The measurement challenge is an ongoing collaboration and we are continuing to expand the resource to include additional image sets across different populations (from contributors) and to compare additional measurement methods (by challengers). The intended use of the measurement challenge resource is for refinement and validation of new and existing mammographic measurement methods. The measurement challenge resource provides a standardised dataset of mammographic images and core data that enables investigators to directly compare methods of measuring mammographic density or other mammographic features in case/control sets of both raw and processed images, for the purposes of the comparing their predictions of breast cancer risk. ETHICS AND DISSEMINATION: Challengers and contributors are required to enter a Research Collaboration Agreement with the University of Melbourne prior to participation in the measurement challenge. The Challenge database of collated data and images are stored in a secure data repository at the University of Melbourne. Ethics approval for the measurement challenge is held at University of Melbourne (HREC ID 0931343.3).

Published
2019

21. A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk

Author

Travis, RC, Perez-Cornago, A, Appleby, PN, Albanes, D, Joshu, CE, Lutsey, PL, Mondul, AM, Platz, EA, Weinstein, SJ, Layne, TM, Helzlsouer, KJ, Visvanathan, K, Palli, D, Peeters, PH, Bueno-de-Mesquita, B, Trichopoulou, A, Gunter, MJ, Tsilidis, KK, Sanchez, M-J, Olsen, A, Brenner, H, Schoettker, B, Perna, L, Holleczek, B, Knekt, P, Rissanen, H, Yeap, BB, Flicker, L, Almeida, OP, Wong, YYE, Chan, JM, Giovannucci, EL, Stampfer, MJ, Ursin, G, Gislefoss, RE, Bjorge, T, Meyer, HE, Blomhoff, R, Tsugane, S, Sawada, N, English, DR, Eyles, DW, Heath, AK, Williamson, EJ, Manjer, J, Malm, J, Almquist, M, Le Marchand, L, Haiman, CA, Wilkens, LR, Schenk, JM, Tangen, CM, Black, A, Cook, MB, Huang, W-Y, Ziegler, RG, Martin, RM, Hamdy, FC, Donovan, JL, Neal, DE, Touvier, M, Hercberg, S, Galan, P, Deschasaux, M, Key, TJ, Allen, NE, Travis, RC, Perez-Cornago, A, Appleby, PN, Albanes, D, Joshu, CE, Lutsey, PL, Mondul, AM, Platz, EA, Weinstein, SJ, Layne, TM, Helzlsouer, KJ, Visvanathan, K, Palli, D, Peeters, PH, Bueno-de-Mesquita, B, Trichopoulou, A, Gunter, MJ, Tsilidis, KK, Sanchez, M-J, Olsen, A, Brenner, H, Schoettker, B, Perna, L, Holleczek, B, Knekt, P, Rissanen, H, Yeap, BB, Flicker, L, Almeida, OP, Wong, YYE, Chan, JM, Giovannucci, EL, Stampfer, MJ, Ursin, G, Gislefoss, RE, Bjorge, T, Meyer, HE, Blomhoff, R, Tsugane, S, Sawada, N, English, DR, Eyles, DW, Heath, AK, Williamson, EJ, Manjer, J, Malm, J, Almquist, M, Le Marchand, L, Haiman, CA, Wilkens, LR, Schenk, JM, Tangen, CM, Black, A, Cook, MB, Huang, W-Y, Ziegler, RG, Martin, RM, Hamdy, FC, Donovan, JL, Neal, DE, Touvier, M, Hercberg, S, Galan, P, Deschasaux, M, Key, TJ, and Allen, NE

Abstract

Previous prospective studies assessing the relationship between circulating concentrations of vitamin D and prostate cancer risk have shown inconclusive results, particularly for risk of aggressive disease. In this study, we examine the association between prediagnostic concentrations of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and the risk of prostate cancer overall and by tumor characteristics. Principal investigators of 19 prospective studies provided individual participant data on circulating 25(OH)D and 1,25(OH)2D for up to 13,462 men with incident prostate cancer and 20,261 control participants. ORs for prostate cancer by study-specific fifths of season-standardized vitamin D concentration were estimated using multivariable-adjusted conditional logistic regression. 25(OH)D concentration was positively associated with risk for total prostate cancer (multivariable-adjusted OR comparing highest vs. lowest study-specific fifth was 1.22; 95% confidence interval, 1.13-1.31; P trend < 0.001). However, this association varied by disease aggressiveness (P heterogeneity = 0.014); higher circulating 25(OH)D was associated with a higher risk of nonaggressive disease (OR per 80 percentile increase = 1.24, 1.13-1.36) but not with aggressive disease (defined as stage 4, metastases, or prostate cancer death, 0.95, 0.78-1.15). 1,25(OH)2D concentration was not associated with risk for prostate cancer overall or by tumor characteristics. The absence of an association of vitamin D with aggressive disease does not support the hypothesis that vitamin D deficiency increases prostate cancer risk. Rather, the association of high circulating 25(OH)D concentration with a higher risk of nonaggressive prostate cancer may be influenced by detection bias. SIGNIFICANCE: This international collaboration comprises the largest prospective study on blood vitamin D and prostate cancer risk and shows no association with aggressive disease but some evidence of a higher

Published
2019

22. Oral contraceptive use and adenocarcinoma of cervix

Author

Ursin, G., Peters, R.K., Henderson, B.E., d'Ablaing, G., III, Monroe, K.R., and Pike, M.C.

Subjects
Oral contraceptives -- Adverse and side effects, Cervical cancer -- Risk factors, Adenocarcinoma -- Risk factors
Published
1994

23. International incidence of childhood cancer, 2001-10 a population-based registry study

Author

Steliarova Foucher Eva, Colombet, Murielle, Ries Lynn, A. G., Moreno, Florencia, Dolya, Anastasia, Bray, Freddie, Hesseling, Peter, Shin, Hee Young Stiller, Iicc, 3 contributors, Bouzbid, S, Hamdi Cherif, M, Hablas, A, Chirpaz, E, Buziba, N, Chesumbai, Gc, Manraj, Ss, Reynders, D, Wabinga, Hr, Chokunonga, E, Moreno, F, Lima, Ca, Asturian Laporte, C, de Oliveira JC, de Aquino JP, Gallagher, Sv, Uribe, Cj, Bravo, Le, Yepez Chamorro MC, Torres Alvarado, G, Galán Alvarez YH, Martinez Reyes FC, Castillo Calvas JC, Mendoza Alava, M, Cueva Ayala, P, Hanchard, B, Fajardo Gutiérrez, A, Zavala Zegarra DE, Barrios, E, Nikiforuk, C, Woods, R, Turner, D, Macintyre, M, Corriveau, A, Navaneelan, T, Bertrand, C, Stuart Panko, H, Wilson, Rj, Kosary, C, Shen, X, Brockhouse, J, Yee, Ga, Mitchell, Tc, Snipes, K, West, D, Rao, C, Bolick, S, Rycroft, Rk, Mueller, L, Zheng, Y, Dosch, K, Brown, H, Vargas, A, Levin, Gm, Bayakly, R, Johnson, C, Shen, T, Ruppert, L, Lynch, Cf, Lai, Sm, Tucker, Tc, Wu, Xc, Schwenn, M, Stern, K, Gershman, S, Copeland, G, Bushhouse, S, Rogers, Db, Jackson Thompson, J, Lemons, D, Frederick, S, Harris, Ja, Riddle, B, Stroup, A, Wiggins, C, Schymura, Mj, Giljahn, Lk, Sheikh, A, Schubert, S, Aldinger, W, Fulton, Jp, Whiteside, M, Nogueira, L, Sweeney, C, Johnson, A, Martin, J, Farley, S, Harrelson, D, Malicki, R, Espinoza, Jr, Hernandez, By, Abulfateh, N, Wang, N, Ngan, R, Lingegowda, Kb, Swaminathan, R, Koyande, Ss, Silverman, B, Ozasa, K, Kanemura, S, Soda, M, Miyashiro, I, Shibata, A, Nimri, O, Won, Yj, Kim, Ch, Hong, Ns, Nam, Hs, Kweon, S, Kim, Wc, Huh, Js, Jung, Kw, Yoo, Ci, Elbasmy, A, Laudico, Av, Lumague, Mr, Almutlag, H, Buasom, R, Srisukho, S, Tanabodee, J, Wiangnon, S, Pongnikorn, D, Sriplung, H, Dirican, O, Eser, S, Le Hoang, M, Hackl, M, Zborovskaya, A, Dimitrova, N, Valerianova, Z, Sekerija, M, Pavlou, P, Dušek, M, Mägi, M, Clavel, J, Lacour, B, Guizard, Av, Bouvier, V, Troussard, X, Woronoff, As, Tretarre, B, Colonna, M, Molinié, F, Bara, S, Velten, M, Marrer, E, Ganry, O, Grosclaude, P, Kaatsch, P, Zeissig, Sr, Holleczek, B, Katalinic, A, Jakab, Z, Birgisson, H, Walsh, Pm, Mangone, L, Merletti, Franco, Magoni, M, Ferretti, S, Serraino, D, Spagnoli, G, Fusco, M, Michiara, M, Tumino, R, Falcini, F, Sensi, F, Tisano, F, Piffer, S, Stracci, F, Tagliabue, G, Smailyte, G, Agius, D, Visser, O, Ursin, G, Didkowska, J, Trojanowski, M, Wojciechowska, U, Forjaz de Lacerda, G, Silva, Ma, Laranja Pontes, J, da Costa Miranda, A, Kaiserova, E, Primic Žakelj, M, Peris Bonet, R, Vicente Raneda ML, Almar Marqués, E, Quirós Garcia JR, Ramos Monserrat, M, Errezola Saizar, M, Alemán Herrera, A, Díaz García JM, Marcos Gragera, R, Sanchez Perez MJ, Ardanaz Aicua, E, Galceran, J, Klint, A, Kuehni, Ce, Bouchardy, C, Levi, F, Bordoni, A, Konzelmann, I, Rohrmann, S, Stiller, Ca, Gavin, At, Brewster, Dh, Phung, H, Rushton, S, Guthridge, S, Aitken, J, D'Onise, K, Venn, A, Farrugian, H, Threlfall, Tj, Laumond, S, Yen Kai Sun, L, Hendrix, J, Ballantine, K, Colombet, M, Dolya, A, Masuyer, E, Steliarova Foucher, E., IICC-3 contributors, Bouzbid, S., Hamdi-Cherif, M., Hablas, A., Chirpaz, E., Buziba, N., Chesumbai, G.C., Manraj, S.S., Reynders, D., Wabinga, H.R., Chokunonga, E., Moreno, F., Lima, C.A., Asturian Laporte, C., de Oliveira, J.C., de Aquino, J.P., Gallagher, S.V., Uribe, C.J., Bravo, L.E., Yepez Chamorro, M.C., Torres Alvarado, G., Galán Alvarez, Y.H., Martinez Reyes, F.C., Castillo Calvas, J.C., Mendoza Alava, M., Cueva Ayala, P., Hanchard, B., Fajardo-Gutiérrez, A., Zavala Zegarra, D.E., Barrios, E., Nikiforuk, C., Woods, R., Turner, D., MacIntyre, M., Corriveau, A., Navaneelan, T., Bertrand, C., Stuart-Panko, H., Wilson, R.J., Kosary, C., Shen, X., Brockhouse, J., Yee, G.A., Mitchell, T.C., Snipes, K., West, D., Rao, C., Bolick, S., Rycroft, R.K., Mueller, L., Zheng, Y., Dosch, K., Brown, H., Vargas, A., Levin, G.M., Bayakly, R., Johnson, C., Shen, T., Ruppert, L., Lynch, C.F., Lai, S.M., Tucker, T.C., Wu, X.C., Schwenn, M., Stern, K., Gershman, S., Copeland, G., Bushhouse, S., Rogers, D.B., Jackson Thompson, J., Lemons, D., Frederick, S., Harris, J.A., Riddle, B., Stroup, A., Wiggins, C., Schymura, M.J., Giljahn, L.K., Sheikh, A., Schubert, S., Aldinger, W., Fulton, J.P., Whiteside, M., Nogueira, L., Sweeney, C., Johnson, A., Martin, J., Farley, S., Harrelson, D., Malicki, R., Espinoza, J.R., Hernandez, B.Y., Abulfateh, N., Wang, N., Ngan, R., Lingegowda, K.B., Swaminathan, R., Koyande, S.S., Silverman, B., Ozasa, K., Kanemura, S., Soda, M., Miyashiro, I., Shibata, A., Nimri, O., Won, Y.J., Kim, C.H., Hong, N.S., Nam, H.S., Kweon, S., Kim, W.C., Huh, J.S., Jung, K.W., Yoo, C.I., Elbasmy, A., Laudico, A.V., Lumague, M.R., AlMutlag, H., Buasom, R., Srisukho, S., Tanabodee, J., Wiangnon, S., Pongnikorn, D., Sriplung, H., Dirican, O., Eser, S., Le Hoang, M., Hackl, M., Zborovskaya, A., Dimitrova, N., Valerianova, Z., Sekerija, M., Pavlou, P., Dušek, M., Mägi, M., Clavel, J., Lacour, B., Guizard, A.V., Bouvier, V., Troussard, X., Woronoff, A.S., Tretarre, B., Colonna, M., Molinié, F., Bara, S., Velten, M., Marrer, E., Ganry, O., Grosclaude, P., Kaatsch, P., Zeissig, S.R., Holleczek, B., Katalinic, A., Jakab, Z., Birgisson, H., Walsh, P.M., Mangone, L., Merletti, F., Magoni, M., Ferretti, S., Serraino, D., Spagnoli, G., Fusco, M., Michiara, M., Tumino, R., Falcini, F., Sensi, F., Tisano, F., Piffer, S., Stracci, F., Tagliabue, G., Smailyte, G., Agius, D., Visser, O., Ursin, G., Didkowska, J., Trojanowski, M., Wojciechowska, U., Forjaz de Lacerda, G., Silva, M.A., Laranja Pontes, J., da Costa Miranda, A., Kaiserova, E., Primic Žakelj, M., Peris-Bonet, R., Vicente Raneda, M.L., Almar Marqués, E., Quirós Garcia, J.R., Ramos Monserrat, M., Errezola Saizar, M., Alemán Herrera, A., Díaz García, J.M., Marcos-Gragera, R., Sanchez-Perez, M.J., Ardanaz Aicua, E., Galceran, J., Klint, A., Kuehni, C.E., Bouchardy, C., Levi, F., Bordoni, A., Konzelmann, I., Rohrmann, S., Stiller, C.A., Gavin, A.T., Brewster, D.H., Phung, H., Rushton, S., Guthridge, S., Aitken, J., D'Onise, K., Venn, A., Farrugian, H., Threlfall, T.J., Laumond, S., Yen Kai Sun, L., Hendrix, J., Ballantine, K., Colombet, M., Dolya, A., Masuyer, E., Steliarova-Foucher, E., University of Zurich, and Steliarova-Foucher, Eva

Subjects
0301 basic medicine, Male, Pediatrics, cancer incidence, sistema de registros, humanos, Ethnic group, adolescente, population-based registry study, North America/epidemiology, 0302 clinical medicine, Neoplasms, Medicine, Registries, Young adult, Child, Cancer in children -- Mortality, Cause of death, neoplasias, education.field_of_study, Incidence (epidemiology), Incidence, South America/epidemiology, Articles, Càncer en els infants -- Mortalitat, incidence, cancer registry, childhood cancer, 3. Good health, adulto joven, Caribbean Region/epidemiology, Oncology, Oceania/epidemiology, 030220 oncology & carcinogenesis, Child, Preschool, Oncology, childhood, cancer, population-based registry study, cancer incidence, 2730 Oncology, Female, medicine.medical_specialty, Oceanía, Adolescent, Oceania, Population, Socio-culturale, 610 Medicine & health, incidencia, Europe/epidemiology, 03 medical and health sciences, Young Adult, Age Distribution, distribución por edades, SDG 3 - Good Health and Well-being, cancer, Humans, education, childhood, lactante, Asia/epidemiology, business.industry, Cancer, Infant, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), medicine.disease, Cancer registry, 030104 developmental biology, Africa/epidemiology, business, Neoplasms/epidemiology, International Classification of Diseases for Oncology, Demography
Abstract

Background Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. Methods This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and nonmalignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001-10. Incidence rates per million person-years for the 0-14 years and 0-19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0-4 years, 5-9 years, 10-14 years, and 15-19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0-14 years were compared with comparable data obtained in the 1980s. Findings Of 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001-10. 385 509 incident cases in children aged 0-19 years occurring in 2.64 billion person-years were included. The overall WSR was 140.6 per million person-years in children aged 0-14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46.4), followed by CNS tumours (WSR 28.2), and lymphomas (WSR 15.2). In children aged 15-19 years (based on 100 860 cases), the ASR was 185.3 per million person-years, the most common being lymphomas (ASR 41.8) and the group of epithelial tumours and melanoma (ASR 39.5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0-14 years has increased from 124.0 (95% CI 123.3-124.7) to 140.6 (140.1-141.1) per million person-years. Interpretation This unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research., International Agency for Research on Cancer and the Union for International Cancer Control.

Published
2017

24. Abstract P1-08-01: Withdrawn

Author

Schoemaker, MJ, primary, Nichols, HB, additional, Wright, LB, additional, Brook, MN, additional, Jones, ME, additional, O'Brien, KM, additional, Adami, H-O, additional, Baglietto, L, additional, Bernstein, L, additional, Bertrand, KA, additional, Boutron-Ruault, M-C, additional, Chen, Y, additional, Connor, AE, additional, Dorronsoro, M, additional, Dossus, L, additional, Eliassen, AH, additional, Giles, GG, additional, Gram, IT, additional, Hankinson, SE, additional, Kaaks, R, additional, Key, TJ, additional, Kirsh, VA, additional, Kitahara, CM, additional, Koh, W-P, additional, Larsson, SC, additional, Linet, MS, additional, Ma, H, additional, Masala, G, additional, Merritt, MA, additional, Milne, RL, additional, Overvad, K, additional, Ozasa, K, additional, Palmer, JR, additional, Riboli, E, additional, Rohan, TE, additional, Sadakane, A, additional, Sund, M, additional, Tamimi, RM, additional, Trichopoulou, A, additional, Ursin, G, additional, Van Gils, CH, additional, Visvanathan, K, additional, Weiderpass, E, additional, Willett, WC, additional, Wolk, A, additional, Yuan, J-M, additional, Zeleniuch-Jacquotte, A, additional, Sandler, DP, additional, and Swerdlow, AJ, additional

Published
2019
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25. Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Information System): a population-based study

Author

Steliarova-Foucher, E. (Eva), Fidler, M.M. (Miranda M), Colombet, M. (Murielle), Lacour, B. (Brigitte), Kaatsch, P. (Peter), Piñeros, M. (Marion), Soerjomataram, I. (Isabelle), Bray, F. (Freddie), Coebergh, J.W. (Jan Willem), Peris-Bonet, R. (Rafael), Stiller, C. (C.), Hackl, M. (Monika), Zborovskaya, A. (Anna), Dimitrova, N. (Nadya), Valerianova, Z. (Zdravka), Dušek, L. (Ladislav), Magi, M. (Margit), Monnereau, A. (Alain), Clavel, J., Velten, M. (Michel), Guizard, A.-V. (Anne-Valérie), Bouvier, V. (Véronique), Troussard, X. (Xavier), Woronoff, A.-S. (Anne-Sophie), Marrer, E. (Emilie), Trétarre, B. (Brigitte), Colonna, M. (M.), Ganry, O. (Olivier), Grosclaude, P. (P.), Holleczek, B. (B.), Jakab, Z. (Zsuzsanna), Tryggvadottir, L. (Laufey), Mangone, L. (Lucia), Merletti, F. (Franco), Ferretti, S. (Stefano), Caruso, B. (Bianca), Michiara, M. (Maria), Tumino, R. (Rosario), Falcini, F. (Fabio), Zanetti, R. (Roberto), Tagliabue, G. (Giovanna), Visser, O.J. (Otto), Ursin, G. (Giske), Mężyk, R. (Ryszard), Kepska, K. (Kamila), Laranja Pontes, J. (José), Primic-Žakelj, M. (Maja), Fernández-Delgado, R. (Rafael), Vicente Raneda, M.L. (Marisa L), Almar Marqués, E. (Enrique), Quirós Garcia, J.R. (José Ramón), Lopez de Munain, A. (Arantza), Marcos-Gragera, R. (R.), Sanchez-Perez, M.-J. (Maria-Jose), Ramos Monserrat, M. (Maria), Ardanaz, E. (Eva), Galceran, J. (J.), Khan, S. (Staffan), Kuehni, C. (Claudia), Bouchardy, C. (C.), Levi, F. (Fabio), Konzelmann, I. (Isabelle), Rohrmann, S. (Sabine), Vernon, S. (Sally), Brewster, D.H. (David H), White, C. (Ceri), Dolya, A. (Anastasia), Steliarova-Foucher, E. (Eva), Fidler, M.M. (Miranda M), Colombet, M. (Murielle), Lacour, B. (Brigitte), Kaatsch, P. (Peter), Piñeros, M. (Marion), Soerjomataram, I. (Isabelle), Bray, F. (Freddie), Coebergh, J.W. (Jan Willem), Peris-Bonet, R. (Rafael), Stiller, C. (C.), Hackl, M. (Monika), Zborovskaya, A. (Anna), Dimitrova, N. (Nadya), Valerianova, Z. (Zdravka), Dušek, L. (Ladislav), Magi, M. (Margit), Monnereau, A. (Alain), Clavel, J., Velten, M. (Michel), Guizard, A.-V. (Anne-Valérie), Bouvier, V. (Véronique), Troussard, X. (Xavier), Woronoff, A.-S. (Anne-Sophie), Marrer, E. (Emilie), Trétarre, B. (Brigitte), Colonna, M. (M.), Ganry, O. (Olivier), Grosclaude, P. (P.), Holleczek, B. (B.), Jakab, Z. (Zsuzsanna), Tryggvadottir, L. (Laufey), Mangone, L. (Lucia), Merletti, F. (Franco), Ferretti, S. (Stefano), Caruso, B. (Bianca), Michiara, M. (Maria), Tumino, R. (Rosario), Falcini, F. (Fabio), Zanetti, R. (Roberto), Tagliabue, G. (Giovanna), Visser, O.J. (Otto), Ursin, G. (Giske), Mężyk, R. (Ryszard), Kepska, K. (Kamila), Laranja Pontes, J. (José), Primic-Žakelj, M. (Maja), Fernández-Delgado, R. (Rafael), Vicente Raneda, M.L. (Marisa L), Almar Marqués, E. (Enrique), Quirós Garcia, J.R. (José Ramón), Lopez de Munain, A. (Arantza), Marcos-Gragera, R. (R.), Sanchez-Perez, M.-J. (Maria-Jose), Ramos Monserrat, M. (Maria), Ardanaz, E. (Eva), Galceran, J. (J.), Khan, S. (Staffan), Kuehni, C. (Claudia), Bouchardy, C. (C.), Levi, F. (Fabio), Konzelmann, I. (Isabelle), Rohrmann, S. (Sabine), Vernon, S. (Sally), Brewster, D.H. (David H), White, C. (Ceri), and Dolya, A. (Anastasia)

Abstract

Background: A deceleration in the increase in cancer incidence in children and adolescents has been reported in several national and regional studies in Europe. Based on a large database representing 1·3 billion person-years over the period 1991–2010, we provide a consolidated report on cancer incidence trends at ages 0–19 years. Methods: We invited all population-based cancer registries operating in European countries to participate in this population-based registry study. We requested a listing of individual records of cancer cases, including sex, age, date of birth, date of cancer diagnosis, tumour sequence number, primary site, morphology, behaviour, and the most valid basis of diagnosis. We also requested population counts in each calendar year by sex and age for the registration area, from official national sources, and specific information about the covered area and registration practices. An eligible registry could become a contributor if it provided quality data for all complete calendar years in the period 1991–2010. Incidence rates and the average annual percentage change with 95% CIs were reported for all cancers and major diagnostic groups, by region and overall, separately for children (age 0–14 years) and adolescents (age 15–19 years). We examined and quantified the stability of the trends with joinpoint analyses. Findings: For the years 1991–2010, 53 registries in 19 countries contributed a total of 180 335 unique cases. We excluded 15 162 (8·4%) of 180 335 cases due to differing practices of registration, and considered the quality indicators for the 165 173 cases included to be satisfactory. The average annual age-standardised incidence was 137·5 (95% CI 136·7–138·3) per million person-years and incidence increased significantly by 0·54% (0·44–0·65) per year in children (age 0–14 years) with no change in trend. In adolescents, the combined European incidence was 176·2 (174·4–178·0) per million person-years based on all 35 138 eligible cases and inc

Published
2018
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26. Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies

Author

Watts, EL, Appleby, PN, Perez-Cornago, A, Bueno-de-Mesquita, HB, Chan, JM, Chen, C, Cohn, BA, Cook, MB, Flicker, L, Freedman, ND, Giles, GG, Giovannucci, E, Gislefoss, RE, Hankey, GJ, Kaaks, R, Knekt, P, Kolonel, LN, Kubo, T, Le Marchand, L, Luben, RN, Luostarinen, T, Mannisto, S, Metter, EJ, Mikami, K, Milne, RL, Ozasa, K, Platz, EA, Quiros, JR, Rissanen, H, Sawada, N, Stampfer, M, Stanczyk, FZ, Stattin, P, Tamakoshi, A, Tangen, CM, Thompson, IM, Tsilidis, KK, Tsugane, S, Ursin, G, Vatten, L, Weiss, NS, Yeap, BB, Allen, NE, Key, TJ, Travis, RC, Watts, EL, Appleby, PN, Perez-Cornago, A, Bueno-de-Mesquita, HB, Chan, JM, Chen, C, Cohn, BA, Cook, MB, Flicker, L, Freedman, ND, Giles, GG, Giovannucci, E, Gislefoss, RE, Hankey, GJ, Kaaks, R, Knekt, P, Kolonel, LN, Kubo, T, Le Marchand, L, Luben, RN, Luostarinen, T, Mannisto, S, Metter, EJ, Mikami, K, Milne, RL, Ozasa, K, Platz, EA, Quiros, JR, Rissanen, H, Sawada, N, Stampfer, M, Stanczyk, FZ, Stattin, P, Tamakoshi, A, Tangen, CM, Thompson, IM, Tsilidis, KK, Tsugane, S, Ursin, G, Vatten, L, Weiss, NS, Yeap, BB, Allen, NE, Key, TJ, and Travis, RC

Abstract

BACKGROUND: Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. OBJECTIVE: To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. DESIGN, SETTING, AND PARTICIPANTS: Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. RESULTS AND LIMITATIONS: Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR=0.77, 95% confidence interval [CI] 0.69-0.86; p<0.001) compared with men with higher concentrations (2nd-10th tenths of the distribution). Heterogeneity was present by tumour grade (phet=0.01), with a lower risk of low-grade disease (OR=0.76, 95% CI 0.67-0.88) and a nonsignificantly higher risk of high-grade disease (OR=1.56, 95% CI 0.95-2.57). There was no evidence of heterogeneity by tumour stage. The observational design is a limitation. CONCLUSIONS: Men with low circulating free testosterone may have a lower risk of overall prostate cancer; this may be due to a direct biological effect, or detection bias. Further research is needed to explore the apparent differential association by tumour grade. PATIENT SUMMARY: In this study, we looked at circulating testosterone levels and r

Published
2018

28. Candidate SNP analyses integrated with mRNA expression and hormone levels reveal influence on mammographic density and breast cancer risk

Author

Biong, M., primary, Suderman, M., additional, Haakensen, VD., additional, Kulle, B., additional, Berg, PR., additional, Gram, I.T., additional, Dumeaux, V., additional, Ursin, G., additional, Helland, Å, additional, H Hallett, M., additional, Børresen-Dale, AL, additional, and Kristensen, V.N., additional

Published
2018
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29. International incidence of childhood cancer, 2001-10: a population-based registry study.

Author

IICC-3 contributors, Bouzbid, S., Hamdi-Cherif, M., Hablas, A., Chirpaz, E., Buziba, N., Chesumbai, G.C., Manraj, S.S., Reynders, D., Wabinga, H.R., Chokunonga, E., Moreno, F., Lima, C.A., Asturian Laporte, C., de Oliveira, J.C., de Aquino, J.P., Gallagher, S.V., Uribe, C.J., Bravo, L.E., Yepez Chamorro, M.C., Torres Alvarado, G., Galán Alvarez, Y.H., Martinez Reyes, F.C., Castillo Calvas, J.C., Mendoza Alava, M., Cueva Ayala, P., Hanchard, B., Fajardo-Gutiérrez, A., Zavala Zegarra, D.E., Barrios, E., Nikiforuk, C., Woods, R., Turner, D., MacIntyre, M., Corriveau, A., Navaneelan, T., Bertrand, C., Stuart-Panko, H., Wilson, R.J., Kosary, C., Shen, X., Brockhouse, J., Yee, G.A., Mitchell, T.C., Snipes, K., West, D., Rao, C., Bolick, S., Rycroft, R.K., Mueller, L., Zheng, Y., Dosch, K., Brown, H., Vargas, A., Levin, G.M., Bayakly, R., Johnson, C., Shen, T., Ruppert, L., Lynch, C.F., Lai, S.M., Tucker, T.C., Wu, X.C., Schwenn, M., Stern, K., Gershman, S., Copeland, G., Bushhouse, S., Rogers, D.B., Jackson Thompson, J., Lemons, D., Frederick, S., Harris, J.A., Riddle, B., Stroup, A., Wiggins, C., Schymura, M.J., Giljahn, L.K., Sheikh, A., Schubert, S., Aldinger, W., Fulton, J.P., Whiteside, M., Nogueira, L., Sweeney, C., Johnson, A., Martin, J., Farley, S., Harrelson, D., Malicki, R., Espinoza, J.R., Hernandez, B.Y., Abulfateh, N., Wang, N., Ngan, R., Lingegowda, K.B., Swaminathan, R., Koyande, S.S., Silverman, B., Ozasa, K., Kanemura, S., Soda, M., Miyashiro, I., Shibata, A., Nimri, O., Won, Y.J., Kim, C.H., Hong, N.S., Nam, H.S., Kweon, S., Kim, W.C., Huh, J.S., Jung, K.W., Yoo, C.I., Elbasmy, A., Laudico, A.V., Lumague, M.R., AlMutlag, H., Buasom, R., Srisukho, S., Tanabodee, J., Wiangnon, S., Pongnikorn, D., Sriplung, H., Dirican, O., Eser, S., Le Hoang, M., Hackl, M., Zborovskaya, A., Dimitrova, N., Valerianova, Z., Sekerija, M., Pavlou, P., Dušek, M., Mägi, M., Clavel, J., Lacour, B., Guizard, A.V., Bouvier, V., Troussard, X., Woronoff, A.S., Tretarre, B., Colonna, M., Molinié, F., Bara, S., Velten, M., Marrer, E., Ganry, O., Grosclaude, P., Kaatsch, P., Zeissig, S.R., Holleczek, B., Katalinic, A., Jakab, Z., Birgisson, H., Walsh, P.M., Mangone, L., Merletti, F., Magoni, M., Ferretti, S., Serraino, D., Spagnoli, G., Fusco, M., Michiara, M., Tumino, R., Falcini, F., Sensi, F., Tisano, F., Piffer, S., Stracci, F., Tagliabue, G., Smailyte, G., Agius, D., Visser, O., Ursin, G., Didkowska, J., Trojanowski, M., Wojciechowska, U., Forjaz de Lacerda, G., Silva, M.A., Laranja Pontes, J., da Costa Miranda, A., Kaiserova, E., Primic Žakelj, M., Peris-Bonet, R., Vicente Raneda, M.L., Almar Marqués, E., Quirós Garcia, J.R., Ramos Monserrat, M., Errezola Saizar, M., Alemán Herrera, A., Díaz García, J.M., Marcos-Gragera, R., Sanchez-Perez, M.J., Ardanaz Aicua, E., Galceran, J., Klint, A., Kuehni, C.E., Bouchardy, C., Levi, F., Bordoni, A., Konzelmann, I., Rohrmann, S., Stiller, C.A., Gavin, A.T., Brewster, D.H., Phung, H., Rushton, S., Guthridge, S., Aitken, J., D'Onise, K., Venn, A., Farrugian, H., Threlfall, T.J., Laumond, S., Yen Kai Sun, L., Hendrix, J., Ballantine, K., Colombet, M., Dolya, A., Masuyer, E., Steliarova-Foucher, E., Ries, LAG, Bray, F., Hesseling, P., Shin, H.Y., IICC-3 contributors, Bouzbid, S., Hamdi-Cherif, M., Hablas, A., Chirpaz, E., Buziba, N., Chesumbai, G.C., Manraj, S.S., Reynders, D., Wabinga, H.R., Chokunonga, E., Moreno, F., Lima, C.A., Asturian Laporte, C., de Oliveira, J.C., de Aquino, J.P., Gallagher, S.V., Uribe, C.J., Bravo, L.E., Yepez Chamorro, M.C., Torres Alvarado, G., Galán Alvarez, Y.H., Martinez Reyes, F.C., Castillo Calvas, J.C., Mendoza Alava, M., Cueva Ayala, P., Hanchard, B., Fajardo-Gutiérrez, A., Zavala Zegarra, D.E., Barrios, E., Nikiforuk, C., Woods, R., Turner, D., MacIntyre, M., Corriveau, A., Navaneelan, T., Bertrand, C., Stuart-Panko, H., Wilson, R.J., Kosary, C., Shen, X., Brockhouse, J., Yee, G.A., Mitchell, T.C., Snipes, K., West, D., Rao, C., Bolick, S., Rycroft, R.K., Mueller, L., Zheng, Y., Dosch, K., Brown, H., Vargas, A., Levin, G.M., Bayakly, R., Johnson, C., Shen, T., Ruppert, L., Lynch, C.F., Lai, S.M., Tucker, T.C., Wu, X.C., Schwenn, M., Stern, K., Gershman, S., Copeland, G., Bushhouse, S., Rogers, D.B., Jackson Thompson, J., Lemons, D., Frederick, S., Harris, J.A., Riddle, B., Stroup, A., Wiggins, C., Schymura, M.J., Giljahn, L.K., Sheikh, A., Schubert, S., Aldinger, W., Fulton, J.P., Whiteside, M., Nogueira, L., Sweeney, C., Johnson, A., Martin, J., Farley, S., Harrelson, D., Malicki, R., Espinoza, J.R., Hernandez, B.Y., Abulfateh, N., Wang, N., Ngan, R., Lingegowda, K.B., Swaminathan, R., Koyande, S.S., Silverman, B., Ozasa, K., Kanemura, S., Soda, M., Miyashiro, I., Shibata, A., Nimri, O., Won, Y.J., Kim, C.H., Hong, N.S., Nam, H.S., Kweon, S., Kim, W.C., Huh, J.S., Jung, K.W., Yoo, C.I., Elbasmy, A., Laudico, A.V., Lumague, M.R., AlMutlag, H., Buasom, R., Srisukho, S., Tanabodee, J., Wiangnon, S., Pongnikorn, D., Sriplung, H., Dirican, O., Eser, S., Le Hoang, M., Hackl, M., Zborovskaya, A., Dimitrova, N., Valerianova, Z., Sekerija, M., Pavlou, P., Dušek, M., Mägi, M., Clavel, J., Lacour, B., Guizard, A.V., Bouvier, V., Troussard, X., Woronoff, A.S., Tretarre, B., Colonna, M., Molinié, F., Bara, S., Velten, M., Marrer, E., Ganry, O., Grosclaude, P., Kaatsch, P., Zeissig, S.R., Holleczek, B., Katalinic, A., Jakab, Z., Birgisson, H., Walsh, P.M., Mangone, L., Merletti, F., Magoni, M., Ferretti, S., Serraino, D., Spagnoli, G., Fusco, M., Michiara, M., Tumino, R., Falcini, F., Sensi, F., Tisano, F., Piffer, S., Stracci, F., Tagliabue, G., Smailyte, G., Agius, D., Visser, O., Ursin, G., Didkowska, J., Trojanowski, M., Wojciechowska, U., Forjaz de Lacerda, G., Silva, M.A., Laranja Pontes, J., da Costa Miranda, A., Kaiserova, E., Primic Žakelj, M., Peris-Bonet, R., Vicente Raneda, M.L., Almar Marqués, E., Quirós Garcia, J.R., Ramos Monserrat, M., Errezola Saizar, M., Alemán Herrera, A., Díaz García, J.M., Marcos-Gragera, R., Sanchez-Perez, M.J., Ardanaz Aicua, E., Galceran, J., Klint, A., Kuehni, C.E., Bouchardy, C., Levi, F., Bordoni, A., Konzelmann, I., Rohrmann, S., Stiller, C.A., Gavin, A.T., Brewster, D.H., Phung, H., Rushton, S., Guthridge, S., Aitken, J., D'Onise, K., Venn, A., Farrugian, H., Threlfall, T.J., Laumond, S., Yen Kai Sun, L., Hendrix, J., Ballantine, K., Colombet, M., Dolya, A., Masuyer, E., Steliarova-Foucher, E., Ries, LAG, Bray, F., Hesseling, P., and Shin, H.Y.

Abstract

Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001-10. Incidence rates per million person-years for the 0-14 years and 0-19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0-4 years, 5-9 years, 10-14 years, and 15-19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0-14 years were compared with comparable data obtained in the 1980s. Of 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001-10. 385 509 incident cases in children aged 0-19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0-14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15-19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied

Published
2017

30. Menopausal hormone therapy and colorectal cancer: A linkage between nationwide registries in Norway

Author

Botteri, E, Støer, N, Sakshaug, S, Graff-Iversen, S, Vangen, S, Hofvind, S, de Lange, T, Bagnardi, V, Ursin, G, Weiderpass, E, Støer, NC, de Lange, Th, Botteri, E, Støer, N, Sakshaug, S, Graff-Iversen, S, Vangen, S, Hofvind, S, de Lange, T, Bagnardi, V, Ursin, G, Weiderpass, E, Støer, NC, and de Lange, Th

Abstract

Objectives With the present study, we aimed to investigate the association between menopausal hormone therapy (HT) and risk of colorectal cancer (CRC). Setting Cohort study based on the linkage of Norwegian population-based registries. Participants We selected 466822 Norwegian women, aged 55-79, alive and residing in Norway as of 1 January 2004, and we followed them from 2004 to 2008. Each woman contributed person-years at risk as non-user, current user and/or past HT user. Outcome measures The outcome of interest was adenocarcinoma of the colorectal tract, overall, by anatomic site and stage at diagnosis. Incidence rate ratios (RRs) with 95% CIs were estimated by Poisson regression and were used to evaluate the association between HT and CRC incidence. Results During the median follow-up of 4.8 years, 138 655 (30%) women received HT and 3799 (0.8%) incident CRCs occurred. Current, but not past, use of HT was associated with a lower risk of CRC (RR 0.88; 95% CI 0.80 to 0.98). RRs for localised, regionally advanced and metastatic CRC were 1.13 (95% CI 0.91 to 1.41), 0.81 (95% CI 0.70 to 0.94) and 0.79 (95% CI 0.62 to 1.00), respectively. RRs for current use of oestrogen therapy (ET) were 0.91 (95% CI 0.80 to 1.04) while RR for current use of combined oestrogen-progestin therapy (EPT) was 0.85 (95% CI 0.70 to 1.03), as compared with no use of HT. The same figures for ET and EPT in oral formulations were 0.83 (95% CI 0.68 to 1.03) and 0.86 (95% CI 0.71 to 1.05), respectively. Conclusions In our nationwide cohort study, HT use lowered the risk of CRC, specifically the most advanced CRC.

Published
2017

31. Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide

Author

Anderson, G, Burton, A, Maskarinec, G, Perez-Gomez, B, Vachon, C, Miao, H, Lajous, M, Lopez-Ridaura, R, Rice, M, Pereira, A, Luisa Garmendia, M, Tamimi, RM, Bertrand, K, Kwong, A, Ursin, G, Lee, E, Qureshi, SA, Ma, H, Vinnicombe, S, Moss, S, Allen, S, Ndumia, R, Vinayak, S, Teo, S-H, Mariapun, S, Fadzli, F, Peplonska, B, Bukowska, A, Nagata, C, Stone, J, Hopper, J, Giles, G, Ozmen, V, Aribal, ME, Schuz, J, Van Gils, CH, Wanders, JOP, Sirous, R, Sirous, M, Hipwell, J, Kim, J, Lee, JW, Dickens, C, Hartman, M, Chia, K-S, Scott, C, Chiarelli, AM, Linton, L, Pollan, M, Flugelman, AA, Salem, D, Kamal, R, Boyd, N, dos-Santos-Silva, I, McCormack, V, Anderson, G, Burton, A, Maskarinec, G, Perez-Gomez, B, Vachon, C, Miao, H, Lajous, M, Lopez-Ridaura, R, Rice, M, Pereira, A, Luisa Garmendia, M, Tamimi, RM, Bertrand, K, Kwong, A, Ursin, G, Lee, E, Qureshi, SA, Ma, H, Vinnicombe, S, Moss, S, Allen, S, Ndumia, R, Vinayak, S, Teo, S-H, Mariapun, S, Fadzli, F, Peplonska, B, Bukowska, A, Nagata, C, Stone, J, Hopper, J, Giles, G, Ozmen, V, Aribal, ME, Schuz, J, Van Gils, CH, Wanders, JOP, Sirous, R, Sirous, M, Hipwell, J, Kim, J, Lee, JW, Dickens, C, Hartman, M, Chia, K-S, Scott, C, Chiarelli, AM, Linton, L, Pollan, M, Flugelman, AA, Salem, D, Kamal, R, Boyd, N, dos-Santos-Silva, I, and McCormack, V

Abstract

BACKGROUND: Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known. METHODS AND FINDINGS: We examined cross-sectional differences in MD by age and menopausal status in over 11,000 breast-cancer-free women aged 35-85 years, from 40 ethnicity- and location-specific population groups across 22 countries in the International Consortium on Mammographic Density (ICMD). MD was read centrally using a quantitative method (Cumulus) and its square-root metrics were analysed using meta-analysis of group-level estimates and linear regression models of pooled data, adjusted for body mass index, reproductive factors, mammogram view, image type, and reader. In all, 4,534 women were premenopausal, and 6,481 postmenopausal, at the time of mammography. A large age-adjusted difference in percent MD (PD) between post- and premenopausal women was apparent (-0.46 cm [95% CI: -0.53, -0.39]) and appeared greater in women with lower breast cancer risk profiles; variation across population groups due to heterogeneity (I2) was 16.5%. Among premenopausal women, the √PD difference per 10-year increase in age was -0.24 cm (95% CI: -0.34, -0.14; I2 = 30%), reflecting a compositional change (lower dense area and higher non-dense area, with no difference in breast area). In postmenopausal women, the corresponding difference in √PD (-0.38 cm [95% CI: -0.44, -0.33]; I2 = 30%) was additionally driven by increasing breast area. The study is limited by different mammography systems and its cross-sectional rather than longitudinal nature. CONCLUSIONS: Declines in MD with increasing age are present premenopausally, continue postmenopausally, and are most pronounced over the menopausal transition. These effects were highly consistent across diverse groups of women worldwide, suggesting that they result from an intrinsic biological, likel

Published
2017

33. International incidence of childhood cancer, 2001–10: a population-based registry study

Author

Steliarova-Foucher, Eva, primary, Colombet, Murielle, additional, Ries, Lynn A G, additional, Moreno, Florencia, additional, Dolya, Anastasia, additional, Bray, Freddie, additional, Hesseling, Peter, additional, Shin, Hee Young, additional, Stiller, Charles A, additional, Bouzbid, S, additional, Hamdi-Cherif, M, additional, Hablas, A, additional, Chirpaz, E, additional, Buziba, N, additional, Chesumbai, GC, additional, Manraj, SS, additional, Reynders, D, additional, Wabinga, HR, additional, Chokunonga, E, additional, Moreno, F, additional, Lima, CA, additional, Asturian Laporte, C, additional, de Oliveira, JC, additional, de Aquino, JA Pontes, additional, Gallagher, SM Vargas, additional, Uribe, CJ, additional, Bravo, LE, additional, Yepez Chamorro, MC, additional, Torres Alvarado, G, additional, Galán Alvarez, YH, additional, Martinez Reyes, FC, additional, Castillo Calvas, JC, additional, Mendoza Alava, M, additional, Cueva Ayala, P, additional, Hanchard, B, additional, Fajardo-Gutiérrez, A, additional, Zavala Zegarra, DE, additional, Barrios, E, additional, Nikiforuk, C, additional, Woods, R, additional, Turner, D, additional, MacIntyre, M, additional, Corriveau, A, additional, Navaneelan, T, additional, Bertrand, C, additional, Stuart-Panko, H, additional, Wilson, RJ, additional, Kosary, C, additional, Shen, X, additional, Brockhouse, J, additional, Yee, GA, additional, Mitchell, TC, additional, Snipes, K, additional, West, D, additional, Rao, C, additional, Bolick, S, additional, Rycroft, RK, additional, Mueller, L, additional, Zheng, Y, additional, Dosch, K, additional, Brown, H, additional, Vargas, A, additional, Levin, GM, additional, Bayakly, R, additional, Johnson, C, additional, Shen, T, additional, Ruppert, L, additional, Lynch, CF, additional, Lai, SM, additional, Tucker, TC, additional, Wu, XC, additional, Schwenn, M, additional, Stern, K, additional, Gershman, S, additional, Copeland, G, additional, Bushhouse, S, additional, Rogers, DB, additional, Jackson Thompson, J, additional, Lemons, D, additional, Frederick, S, additional, Harris, JA, additional, Riddle, B, additional, Stroup, A, additional, Wiggins, C, additional, Schymura, MJ, additional, Giljahn, LK, additional, Sheikh, A, additional, Schubert, S, additional, Aldinger, W, additional, Fulton, JP, additional, Whiteside, M, additional, Nogueira, L, additional, Sweeney, C, additional, Johnson, A, additional, Martin, J, additional, Farley, S, additional, Harrelson, D, additional, Malicki, R, additional, Espinoza, JR, additional, Hernandez, BY, additional, Abulfateh, N, additional, Wang, N, additional, Ngan, RKC, additional, Lingegowda, KB, additional, Swaminathan, R, additional, Koyande, SS, additional, Silverman, B, additional, Ozasa, K, additional, Kanemura, S, additional, Soda, M, additional, Miyashiro, I, additional, Shibata, A, additional, Nimri, O, additional, Won, YJ, additional, Kim, CH, additional, Hong, NS, additional, Nam, HS, additional, Kweon, S, additional, Kim, WC, additional, Huh, JS, additional, Jung, KW, additional, Yoo, CI, additional, Elbasmy, A, additional, Laudico, AV, additional, Lumague, MR, additional, AlMutlag, H, additional, Buasom, R, additional, Srisukho, S, additional, Tanabodee, J, additional, Wiangnon, S, additional, Pongnikorn, D, additional, Sriplung, H, additional, Dirican, O, additional, Eser, S, additional, Le Hoang, M, additional, Hackl, M, additional, Zborovskaya, A, additional, Dimitrova, N, additional, Valerianova, Z, additional, Sekerija, M, additional, Pavlou, P, additional, Dušek, M, additional, Mägi, M, additional, Clavel, J, additional, Lacour, B, additional, Guizard, AV, additional, Bouvier, V, additional, Troussard, X, additional, Woronoff, AS, additional, Tretarre, B, additional, Colonna, M, additional, Molinié, F, additional, Bara, S, additional, Velten, M, additional, Marrer, E, additional, Ganry, O, additional, Grosclaude, P, additional, Kaatsch, P, additional, Zeissig, SR, additional, Holleczek, B, additional, Katalinic, A, additional, Jakab, Z, additional, Birgisson, H, additional, Walsh, PM, additional, Mangone, L, additional, Merletti, F, additional, Magoni, M, additional, Ferretti, S, additional, Serraino, D, additional, Spagnoli, G, additional, Fusco, M, additional, Michiara, M, additional, Tumino, R, additional, Falcini, F, additional, Sensi, F, additional, Tisano, F, additional, Piffer, S, additional, Stracci, F, additional, Tagliabue, G, additional, Smailyte, G, additional, Agius, D, additional, Visser, O, additional, Ursin, G, additional, Didkowska, J, additional, Trojanowski, M, additional, Wojciechowska, U, additional, Forjaz de Lacerda, G, additional, Silva, MA, additional, Laranja Pontes, J, additional, da Costa Miranda, A, additional, Kaiserova, E, additional, Primic Žakelj, M, additional, Peris-Bonet, R, additional, Vicente Raneda, ML, additional, Almar Marqués, E, additional, Quirós Garcia, JR, additional, Ramos Monserrat, M, additional, Errezola Saizar, M, additional, Alemán Herrera, A, additional, Díaz García, JM, additional, Marcos-Gragera, R, additional, Sanchez-Perez, MJ, additional, Ardanaz Aicua, E, additional, Galceran, J, additional, Klint, A, additional, Kuehni, CE, additional, Bouchardy, C, additional, Levi, F, additional, Bordoni, A, additional, Konzelmann, I, additional, Rohrmann, S, additional, Stiller, CA, additional, Gavin, AT, additional, Brewster, DH, additional, Phung, H, additional, Rushton, S, additional, Guthridge, S, additional, Aitken, J, additional, D'Onise, K, additional, Venn, A, additional, Farrugian, H, additional, Threlfall, TJ, additional, Laumond, S, additional, Yen Kai Sun, L, additional, Hendrix, J, additional, Ballantine, K, additional, Colombet, M, additional, Dolya, A, additional, Masuyer, E, additional, and Steliarova-Foucher, E, additional

Published
2017
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34. Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

Author

Guo, Y. (Yan), Warren Andersen, S. (Shaneda), Shu, X.-O. (Xiao-Ou), Michailidou, K. (Kyriaki), Bolla, M.K. (Manjeet K.), Wang, Q. (Qing), García-Closas, M. (Montserrat), Milne, R.L. (Roger), Schmidt, M.K. (Marjanka), Chang-Claude, J. (Jenny), Dunning, A.M. (Alison), Bojesen, S.E. (Stig), Ahsan, H. (Habibul), Aittomäki, K. (Kristiina), Andrulis, I.L. (Irene), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Beckmann, M.W. (Matthias), Beeghly-Fadiel, A. (Alicia), Benítez, J. (Javier), Bogdanova, N.V. (Natalia), Bonnani, B. (Bernardo), Borresen-Dale, A.-L. (Anne-Lise), Brand, J.S. (Judith S.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brüning, T. (Thomas), Burwinkel, B. (Barbara), Casey, G. (Graham), Chenevix-Trench, G. (Georgia), Couch, F.J. (Fergus), Cox, A. (Angela), Cross, S.S. (Simon), Czene, K. (Kamila), Devilee, P. (Peter), Dörk, T. (Thilo), Dumont, M. (Martine), Fasching, P.A. (Peter), Figueroa, J.D. (Jonine), Flesch-Janys, D. (Dieter), Fletcher, O. (Olivia), Flyger, H. (Henrik), Fostira, F. (Florentia), Gammon, M. (Marilie), Giles, G.G. (Graham), Guénel, P. (Pascal), Haiman, C.A. (Christopher A.), Hamann, U. (Ute), Hooning, M.J. (Maartje), Hopper, J.L. (John), Jakubowska, A. (Anna), Jasmine, F. (Farzana), Jenkins, M. (Mark), John, E.M. (Esther), Johnson, N. (Nichola), Jones, M. (Michael), Kabisch, M. (Maria), Kibriya, M.G. (Muhammad), Knight, J.A. (Julia), Koppert, L.B. (Linetta), Kosma, V-M. (Veli-Matti), Kristensen, V. (Vessela), Le Marchand, L. (Loic), Lee, E. (Eunjung), Li, J. (Jingmei), Lindblom, A. (Annika), Luben, R.N. (Robert), Lubinski, J. (Jan), Malone, K. (Kathi), Mannermaa, A. (Arto), Margolin, S. (Sara), Marme, F. (Federick), McLean, C.A. (Catriona Ann), Meijers-Heijboer, E.J. (Hanne), Meindl, A. (Alfons), Neuhausen, S.L. (Susan), Nevanlinna, H. (Heli), Neven, P. (Patrick), Olson, J.E. (Janet), Perez, J.I.A. (Jose Ignacio Arias), Perkins, B. (Barbara), Peterlongo, P. (Paolo), Phillips, K.-A. (Kelly-Anne), Pykäs, K. (Katri), Rudolph, A. (Anja), Santella, R. (Regina), Sawyer, E.J. (Elinor), Schmutzler, R.K. (Rita), Seynaeve, C.M. (Caroline), Shah, M. (Mitul), Shrubsole, M. (Martha), Southey, M.C. (Melissa), Swerdlow, A.J. (Anthony ), Toland, A.E. (Amanda), Tomlinson, I.P. (Ian), Torres, D. (Diana), Truong, T. (Thérèse), Ursin, G. (Giske), Luijt, R.B. (Rob) van der, Verhoef, S., Whittemore, A.S. (Alice S.), Winqvist, R. (Robert), Zhao, H. (Hui), Zhao, S. (Shilin), Hall, P. (Per), Simard, J. (Jacques), Kraft, P. (Peter), Pharoah, P.D.P. (Paul), Hunter, D. (David), Easton, D.F. (Douglas F.), Zheng, W. (Wei), Guo, Y. (Yan), Warren Andersen, S. (Shaneda), Shu, X.-O. (Xiao-Ou), Michailidou, K. (Kyriaki), Bolla, M.K. (Manjeet K.), Wang, Q. (Qing), García-Closas, M. (Montserrat), Milne, R.L. (Roger), Schmidt, M.K. (Marjanka), Chang-Claude, J. (Jenny), Dunning, A.M. (Alison), Bojesen, S.E. (Stig), Ahsan, H. (Habibul), Aittomäki, K. (Kristiina), Andrulis, I.L. (Irene), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Beckmann, M.W. (Matthias), Beeghly-Fadiel, A. (Alicia), Benítez, J. (Javier), Bogdanova, N.V. (Natalia), Bonnani, B. (Bernardo), Borresen-Dale, A.-L. (Anne-Lise), Brand, J.S. (Judith S.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brüning, T. (Thomas), Burwinkel, B. (Barbara), Casey, G. (Graham), Chenevix-Trench, G. (Georgia), Couch, F.J. (Fergus), Cox, A. (Angela), Cross, S.S. (Simon), Czene, K. (Kamila), Devilee, P. (Peter), Dörk, T. (Thilo), Dumont, M. (Martine), Fasching, P.A. (Peter), Figueroa, J.D. (Jonine), Flesch-Janys, D. (Dieter), Fletcher, O. (Olivia), Flyger, H. (Henrik), Fostira, F. (Florentia), Gammon, M. (Marilie), Giles, G.G. (Graham), Guénel, P. (Pascal), Haiman, C.A. (Christopher A.), Hamann, U. (Ute), Hooning, M.J. (Maartje), Hopper, J.L. (John), Jakubowska, A. (Anna), Jasmine, F. (Farzana), Jenkins, M. (Mark), John, E.M. (Esther), Johnson, N. (Nichola), Jones, M. (Michael), Kabisch, M. (Maria), Kibriya, M.G. (Muhammad), Knight, J.A. (Julia), Koppert, L.B. (Linetta), Kosma, V-M. (Veli-Matti), Kristensen, V. (Vessela), Le Marchand, L. (Loic), Lee, E. (Eunjung), Li, J. (Jingmei), Lindblom, A. (Annika), Luben, R.N. (Robert), Lubinski, J. (Jan), Malone, K. (Kathi), Mannermaa, A. (Arto), Margolin, S. (Sara), Marme, F. (Federick), McLean, C.A. (Catriona Ann), Meijers-Heijboer, E.J. (Hanne), Meindl, A. (Alfons), Neuhausen, S.L. (Susan), Nevanlinna, H. (Heli), Neven, P. (Patrick), Olson, J.E. (Janet), Perez, J.I.A. (Jose Ignacio Arias), Perkins, B. (Barbara), Peterlongo, P. (Paolo), Phillips, K.-A. (Kelly-Anne), Pykäs, K. (Katri), Rudolph, A. (Anja), Santella, R. (Regina), Sawyer, E.J. (Elinor), Schmutzler, R.K. (Rita), Seynaeve, C.M. (Caroline), Shah, M. (Mitul), Shrubsole, M. (Martha), Southey, M.C. (Melissa), Swerdlow, A.J. (Anthony ), Toland, A.E. (Amanda), Tomlinson, I.P. (Ian), Torres, D. (Diana), Truong, T. (Thérèse), Ursin, G. (Giske), Luijt, R.B. (Rob) van der, Verhoef, S., Whittemore, A.S. (Alice S.), Winqvist, R. (Robert), Zhao, H. (Hui), Zhao, S. (Shilin), Hall, P. (Per), Simard, J. (Jacques), Kraft, P. (Peter), Pharoah, P.D.P. (Paul), Hunter, D. (David), Easton, D.F. (Douglas F.), and Zheng, W. (Wei)

Published
2016
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35. Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Author

Couch, F.J. (Fergus), Kuchenbaecker, K.B. (Karoline), Michailidou, K. (Kyriaki), Mendoza-Fandino, G.A. (Gustavo A.), Nord, S. (Silje), Lilyquist, J. (Janna), Olswold, C. (Curtis), Hallberg, B. (Boubou), Agata, S. (Simona), Ahsan, H. (Habibul), Aittomäki, K. (Kristiina), Ambrosone, C.B. (Christine), Andrulis, I.L. (Irene), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Arun, B.K. (Banu), Arver, B. (Brita Wasteson), Barile, M. (Monica), Barkardottir, R.B. (Rosa), Barrowdale, D. (Daniel), Beckmann, L. (Lars), Beckmann, M.W. (Matthias), Benítez, J. (Javier), Blank, S.V. (Stephanie), Blomqvist, C. (Carl), Bogdanova, N.V. (Natalia), Bojesen, S.E. (Stig), Bolla, M.K. (Manjeet), Bonnani, B. (Bernardo), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Burwinkel, B. (Barbara), Buys, S.S. (Saundra S.), Caldes, T. (Trinidad), Caligo, M.A. (Maria), Canzian, F. (Federico), Carpenter, T.A. (Adrian), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen J.), Chung, W.K. (Wendy K.), Claes, K.B.M. (Kathleen B.M.), Cox, A. (Angela), Cross, S.S. (Simon), Cunningham, J.M. (Julie), Czene, K. (Kamila), Daly, M.B. (Mary B.), Damiola, F. (Francesca), Darabi, H. (Hatef), Hoya, M. (Miguel) de La, Devilee, P. (Peter), Díez, O. (Orland), Ding, Y.C. (Yuan), Dolcetti, R. (Riccardo), Domchek, S.M. (Susan), Dorfling, C.M. (Cecilia), Santos Silva, I. (Isabel) dos, Dumont, M. (Martine), Dunning, A.M. (Alison), Eccles, D. (Diana), Ehrencrona, H. (Hans), Ekici, A.B. (Arif), Eliassen, H. (Heather), Ellis, S.D. (Steve), Fasching, P.A. (Peter), Figueroa, J.D. (Jonine), Flesch-Janys, D. (Dieter), Försti, A. (Asta), Fostira, F. (Florentia), Foulkes, W.D. (William), Friebel, M.O.W. (Mark ), Friedman, E. (Eitan), Frost, D. (Debra), Gabrielson, M. (Marike), Gammon, M. (Marilie), Ganz, P.A. (Patricia A.), Gapstur, S.M. (Susan M.), Garber, J. (Judy), Gaudet, M.M. (Mia), Gayther, S.A. (Simon), Gerdes, A-M. (Anne-Marie), Ghoussaini, M. (Maya), Giles, G.G. (Graham), Glendon, G. (Gord), Godwin, A.K. (Andrew K.), Goldberg, M.S. (Mark), Goldgar, D. (David), González-Neira, A. (Anna), Greene, M.H. (Mark H.), Gronwald, J. (Jacek), Guénel, P. (Pascal), Gunter, M.J. (Marc J.), Haeberle, L. (Lothar), Haiman, C.A. (Christopher A.), Hamann, U. (Ute), Hansen, T.V.O. (Thomas), Hart, S. (Stewart), Healey, S. (Sue), Heikkinen, T. (Tuomas), Henderson, B.E. (Brian), Herzog, J. (Josef), Hogervorst, F.B.L. (Frans), Hollestelle, A. (Antoinette), Hooning, M.J. (Maartje), Hoover, R.N. (Robert), Hopper, J.L. (John), Humphreys, K. (Keith), Hunter, D. (David), Huzarski, T. (Tomasz), Imyanitov, E.N. (Evgeny N.), Isaacs, C. (Claudine), Jakubowska, A. (Anna), James, M. (Margaret), Janavicius, R. (Ramunas), Jensen, U.B., John, E.M. (Esther), Jones, M. (Michael), Kabisch, M. (Maria), Kar, S. (Siddhartha), Karlan, B.Y. (Beth Y.), Khan, S. (Sofia), Khaw, K.T., Kibriya, M.G. (Muhammad), Knight, J.A. (Julia), Ko, Y.-D. (Yon-Dschun), Konstantopoulou, I. (I.), Kosma, V-M. (Veli-Matti), Kristensen, V. (Vessela), Kwong, A. (Ava), Laitman, Y. (Yael), Lambrechts, D. (Diether), Lázaro, C. (Conxi), Lee, E. (Eunjung), Le Marchand, L. (Loic), Lester, K.J. (Kathryn), Lindblom, A. (Annika), Lindor, N.M. (Noralane), Lindstrom, S. (Stephen), Liu, J. (Jianjun), Long, J. (Jirong), Lubinski, J. (Jan), Mai, P.L. (Phuong), Makalic, E. (Enes), Malone, K.E. (Kathleen E.), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Marme, F. (Federick), Martens, J.W.M. (John), McGuffog, L. (Lesley), Meindl, A. (Alfons), Miller, A. (Austin), Milne, R.L. (Roger), Miron, P. (Penelope), Montagna, M. (Marco), Mazoyer, S. (Sylvie), Mulligan, A.-M. (Anna-Marie), Muranen, T.A. (Taru), Nathanson, K.L. (Katherine), Neuhausen, S.L. (Susan), Nevanlinna, H. (Heli), Nordestgaard, B.G. (Børge), Nussbaum, R. (Robert), Offit, K. (Kenneth), Olah, E., Olopade, O.I. (Olufunmilayo I.), Olson, J.E. (Janet), Osorio, A. (Ana), Park, S.K. (Sue K.), Peeters, P.H.M., Peissel, B. (Bernard), Peterlongo, P. (Paolo), Peto, J. (Julian), Phelan, C. (Catherine), Pilarski, R. (Robert), Poppe, B. (Bruce), Pykäs, K. (Katri), Radice, P. (Paolo), Rahman, N. (Nazneen), Rantala, J. (Johanna), Rappaport, C. (Christine), Rennert, G. (Gad), Richardson, A.L. (Andrea), Robson, M. (Mark), Romieu, I. (Isabelle), Rudolph, A. (Anja), Rutgers, E.J.T. (Emiel), Sanchez, M.-J. (Maria-Jose), Santella, R. (Regina), Sawyer, E.J. (Elinor), Schmidt, D.F. (Daniel), Schmidt, M.K. (Marjanka), Schmutzler, R.K. (Rita), Schumacher, F.R. (Fredrick), Scott, R.J. (Rodney), Senter, L. (Leigha), Sharma, P. (Priyanka), Simard, J. (Jacques), Singer, C.F. (Christian), Sinilnikova, O. (Olga), Soucy, P. (Penny), Southey, M.C. (Melissa), Steinemann, D. (Doris), Stenmark-Askmalm, M. (Marie), Stoppa-Lyonnet, D. (Dominique), Swerdlow, A.J. (Anthony ), Szabo, C. (Csilla), Tamimi, R. (Rulla), Tapper, W. (William), Teixeira, P.J., Teo, S.-H. (Soo-Hwang), Terry, M.B. (Mary Beth), Thomassen, M. (Mads), Thompson, D. (Deborah), Tihomirova, L. (Laima), Toland, A.E. (Amanda), Tollenaar, R.A.E.M. (Rob), Tomlinson, I.P. (Ian), Truong, T. (Thérèse), Tsimiklis, H. (Helen), Teulé, A. (A.), Tumino, R. (Rosario), Tung, N. (Nadine), Turnbull, C. (Clare), Ursin, G. (Giski), Deurzen, C.H.M. (Carolien) van, Rensburg, E.J. (Elizabeth) van, Varon-Mateeva, R. (Raymonda), Wang, Z. (Zhaoming), Wang-Gohrke, S. (Shan), Weiderpass, E. (Elisabete), Weitzel, J.N. (Jeffrey), Whittemore, A.S. (Alice S.), Wildiers, H. (Hans), Winqvist, R. (Robert), Yang, X.R. (Xiaohong R.), Yannoukakos, D. (Drakoulis), Yao, S. (Song), Zamora, M.P. (Pilar), Zheng, W. (Wei), Hall, P. (Per), Kraft, P. (Peter), Vachon, C. (Celine), Slager, S. (Susan), Chenevix-Trench, G. (Georgia), Pharoah, P.D.P. (Paul), Monteiro, A.A.N. (Alvaro A. N.), García-Closas, M. (Montserrat), Easton, D.F. (Douglas F.), Antoniou, A.C. (Antonis), Couch, F.J. (Fergus), Kuchenbaecker, K.B. (Karoline), Michailidou, K. (Kyriaki), Mendoza-Fandino, G.A. (Gustavo A.), Nord, S. (Silje), Lilyquist, J. (Janna), Olswold, C. (Curtis), Hallberg, B. (Boubou), Agata, S. (Simona), Ahsan, H. (Habibul), Aittomäki, K. (Kristiina), Ambrosone, C.B. (Christine), Andrulis, I.L. (Irene), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Arun, B.K. (Banu), Arver, B. (Brita Wasteson), Barile, M. (Monica), Barkardottir, R.B. (Rosa), Barrowdale, D. (Daniel), Beckmann, L. (Lars), Beckmann, M.W. (Matthias), Benítez, J. (Javier), Blank, S.V. (Stephanie), Blomqvist, C. (Carl), Bogdanova, N.V. (Natalia), Bojesen, S.E. (Stig), Bolla, M.K. (Manjeet), Bonnani, B. (Bernardo), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Burwinkel, B. (Barbara), Buys, S.S. (Saundra S.), Caldes, T. (Trinidad), Caligo, M.A. (Maria), Canzian, F. (Federico), Carpenter, T.A. (Adrian), Chang-Claude, J. (Jenny), Chanock, S.J. (Stephen J.), Chung, W.K. (Wendy K.), Claes, K.B.M. (Kathleen B.M.), Cox, A. (Angela), Cross, S.S. (Simon), Cunningham, J.M. (Julie), Czene, K. (Kamila), Daly, M.B. (Mary B.), Damiola, F. (Francesca), Darabi, H. (Hatef), Hoya, M. (Miguel) de La, Devilee, P. (Peter), Díez, O. (Orland), Ding, Y.C. (Yuan), Dolcetti, R. (Riccardo), Domchek, S.M. (Susan), Dorfling, C.M. (Cecilia), Santos Silva, I. (Isabel) dos, Dumont, M. (Martine), Dunning, A.M. (Alison), Eccles, D. (Diana), Ehrencrona, H. (Hans), Ekici, A.B. (Arif), Eliassen, H. (Heather), Ellis, S.D. (Steve), Fasching, P.A. (Peter), Figueroa, J.D. (Jonine), Flesch-Janys, D. (Dieter), Försti, A. (Asta), Fostira, F. (Florentia), Foulkes, W.D. (William), Friebel, M.O.W. (Mark ), Friedman, E. (Eitan), Frost, D. (Debra), Gabrielson, M. (Marike), Gammon, M. (Marilie), Ganz, P.A. (Patricia A.), Gapstur, S.M. (Susan M.), Garber, J. (Judy), Gaudet, M.M. (Mia), Gayther, S.A. (Simon), Gerdes, A-M. (Anne-Marie), Ghoussaini, M. (Maya), Giles, G.G. (Graham), Glendon, G. (Gord), Godwin, A.K. (Andrew K.), Goldberg, M.S. (Mark), Goldgar, D. (David), González-Neira, A. (Anna), Greene, M.H. (Mark H.), Gronwald, J. (Jacek), Guénel, P. (Pascal), Gunter, M.J. (Marc J.), Haeberle, L. (Lothar), Haiman, C.A. (Christopher A.), Hamann, U. (Ute), Hansen, T.V.O. (Thomas), Hart, S. (Stewart), Healey, S. (Sue), Heikkinen, T. (Tuomas), Henderson, B.E. (Brian), Herzog, J. (Josef), Hogervorst, F.B.L. (Frans), Hollestelle, A. (Antoinette), Hooning, M.J. (Maartje), Hoover, R.N. (Robert), Hopper, J.L. (John), Humphreys, K. (Keith), Hunter, D. (David), Huzarski, T. (Tomasz), Imyanitov, E.N. (Evgeny N.), Isaacs, C. (Claudine), Jakubowska, A. (Anna), James, M. (Margaret), Janavicius, R. (Ramunas), Jensen, U.B., John, E.M. (Esther), Jones, M. (Michael), Kabisch, M. (Maria), Kar, S. (Siddhartha), Karlan, B.Y. (Beth Y.), Khan, S. (Sofia), Khaw, K.T., Kibriya, M.G. (Muhammad), Knight, J.A. (Julia), Ko, Y.-D. (Yon-Dschun), Konstantopoulou, I. (I.), Kosma, V-M. (Veli-Matti), Kristensen, V. (Vessela), Kwong, A. (Ava), Laitman, Y. (Yael), Lambrechts, D. (Diether), Lázaro, C. (Conxi), Lee, E. (Eunjung), Le Marchand, L. (Loic), Lester, K.J. (Kathryn), Lindblom, A. (Annika), Lindor, N.M. (Noralane), Lindstrom, S. (Stephen), Liu, J. (Jianjun), Long, J. (Jirong), Lubinski, J. (Jan), Mai, P.L. (Phuong), Makalic, E. (Enes), Malone, K.E. (Kathleen E.), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Marme, F. (Federick), Martens, J.W.M. (John), McGuffog, L. (Lesley), Meindl, A. (Alfons), Miller, A. (Austin), Milne, R.L. (Roger), Miron, P. (Penelope), Montagna, M. (Marco), Mazoyer, S. (Sylvie), Mulligan, A.-M. (Anna-Marie), Muranen, T.A. (Taru), Nathanson, K.L. (Katherine), Neuhausen, S.L. (Susan), Nevanlinna, H. (Heli), Nordestgaard, B.G. (Børge), Nussbaum, R. (Robert), Offit, K. (Kenneth), Olah, E., Olopade, O.I. (Olufunmilayo I.), Olson, J.E. (Janet), Osorio, A. (Ana), Park, S.K. (Sue K.), Peeters, P.H.M., Peissel, B. (Bernard), Peterlongo, P. (Paolo), Peto, J. (Julian), Phelan, C. (Catherine), Pilarski, R. (Robert), Poppe, B. (Bruce), Pykäs, K. (Katri), Radice, P. (Paolo), Rahman, N. (Nazneen), Rantala, J. (Johanna), Rappaport, C. (Christine), Rennert, G. (Gad), Richardson, A.L. (Andrea), Robson, M. (Mark), Romieu, I. (Isabelle), Rudolph, A. (Anja), Rutgers, E.J.T. (Emiel), Sanchez, M.-J. (Maria-Jose), Santella, R. (Regina), Sawyer, E.J. (Elinor), Schmidt, D.F. (Daniel), Schmidt, M.K. (Marjanka), Schmutzler, R.K. (Rita), Schumacher, F.R. (Fredrick), Scott, R.J. (Rodney), Senter, L. (Leigha), Sharma, P. (Priyanka), Simard, J. (Jacques), Singer, C.F. (Christian), Sinilnikova, O. (Olga), Soucy, P. (Penny), Southey, M.C. (Melissa), Steinemann, D. (Doris), Stenmark-Askmalm, M. (Marie), Stoppa-Lyonnet, D. (Dominique), Swerdlow, A.J. (Anthony ), Szabo, C. (Csilla), Tamimi, R. (Rulla), Tapper, W. (William), Teixeira, P.J., Teo, S.-H. (Soo-Hwang), Terry, M.B. (Mary Beth), Thomassen, M. (Mads), Thompson, D. (Deborah), Tihomirova, L. (Laima), Toland, A.E. (Amanda), Tollenaar, R.A.E.M. (Rob), Tomlinson, I.P. (Ian), Truong, T. (Thérèse), Tsimiklis, H. (Helen), Teulé, A. (A.), Tumino, R. (Rosario), Tung, N. (Nadine), Turnbull, C. (Clare), Ursin, G. (Giski), Deurzen, C.H.M. (Carolien) van, Rensburg, E.J. (Elizabeth) van, Varon-Mateeva, R. (Raymonda), Wang, Z. (Zhaoming), Wang-Gohrke, S. (Shan), Weiderpass, E. (Elisabete), Weitzel, J.N. (Jeffrey), Whittemore, A.S. (Alice S.), Wildiers, H. (Hans), Winqvist, R. (Robert), Yang, X.R. (Xiaohong R.), Yannoukakos, D. (Drakoulis), Yao, S. (Song), Zamora, M.P. (Pilar), Zheng, W. (Wei), Hall, P. (Per), Kraft, P. (Peter), Vachon, C. (Celine), Slager, S. (Susan), Chenevix-Trench, G. (Georgia), Pharoah, P.D.P. (Paul), Monteiro, A.A.N. (Alvaro A. N.), García-Closas, M. (Montserrat), Easton, D.F. (Douglas F.), and Antoniou, A.C. (Antonis)

Abstract

Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10-8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negati

Published
2016
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36. Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Author

Couch, FJ, Kuchenbaecker, KB, Michailidou, K, Mendoza-Fandino, GA, Nord, S, Lilyquist, J, Olswold, C, Hallberg, E, Agata, S, Ahsan, H, Aittomaeki, K, Ambrosone, C, Andrulis, IL, Anton-Culver, H, Arndt, V, Arun, BK, Arver, B, Barile, M, Barkardottir, RB, Barrowdale, D, Beckmann, L, Beckmann, MW, Benitez, J, Blank, SV, Blomqvist, C, Bogdanova, NV, Bojesen, SE, Bolla, MK, Bonanni, B, Brauch, H, Brenner, H, Burwinkel, B, Buys, SS, Caldes, T, Caligo, MA, Canzian, F, Carpenter, J, Chang-Claude, J, Chanock, SJ, Chung, WK, Claes, KBM, Cox, A, Cross, SS, Cunningham, JM, Czene, K, Daly, MB, Damiola, F, Darabi, H, de la Hoya, M, Devilee, P, Diez, O, Ding, YC, Dolcetti, R, Domchek, SM, Dorfling, CM, dos-Santos-Silva, I, Dumont, M, Dunning, AM, Eccles, DM, Ehrencrona, H, Ekici, AB, Eliassen, H, Ellis, S, Fasching, PA, Figueroa, J, Flesch-Janys, D, Foersti, A, Fostira, F, Foulkes, WD, Friebel, T, Friedman, E, Frost, D, Gabrielson, M, Gammon, MD, Ganz, PA, Gapstur, SM, Garber, J, Gaudet, MM, Gayther, SA, Gerdes, A-M, Ghoussaini, M, Giles, GG, Glendon, G, Godwin, AK, Goldberg, MS, Goldgar, DE, Gonzalez-Neira, A, Greene, MH, Gronwald, J, Guenel, P, Gunter, M, Haeberle, L, Haiman, CA, Hamann, U, Hansen, TVO, Hart, S, Healey, S, Heikkinen, T, Henderson, BE, Herzog, J, Hogervorst, FBL, Hollestelle, A, Hooning, MJ, Hoover, RN, Hopper, JL, Humphreys, K, Hunter, DJ, Huzarski, T, Imyanitov, EN, Isaacs, C, Jakubowska, A, James, P, Janavicius, R, Jensen, UB, John, EM, Jones, M, Kabisch, M, Kar, S, Karlan, BY, Khan, S, Khaw, K-T, Kibriya, MG, Knight, JA, Ko, Y-D, Konstantopoulou, I, Kosma, V-M, Kristensen, V, Kwong, A, Laitman, Y, Lambrechts, D, Lazaro, C, Lee, E, Le Marchand, L, Lester, J, Lindblom, A, Lindor, N, Lindstrom, S, Liu, J, Long, J, Lubinski, J, Mai, PL, Makalic, E, Malone, KE, Mannermaa, A, Manoukian, S, Margolin, S, Marme, F, Martens, JWM, McGuffog, L, Meindl, A, Miller, A, Milne, RL, Miron, P, Montagna, M, Mazoyer, S, Mulligan, AM, Muranen, TA, Nathanson, KL, Neuhausen, SL, Nevanlinna, H, Nordestgaard, BG, Nussbaum, RL, Offit, K, Olah, E, Olopade, OI, Olson, JE, Osorio, A, Park, SK, Peeters, PH, Peissel, B, Peterlongo, P, Peto, J, Phelan, CM, Pilarski, R, Poppe, B, Pylkaes, K, Radice, P, Rahman, N, Rantala, J, Rappaport, C, Rennert, G, Richardson, A, Robson, M, Romieu, I, Rudolph, A, Rutgers, EJ, Sanchez, M-J, Santella, RM, Sawyer, EJ, Schmidt, DF, Schmidt, MK, Schmutzler, RK, Schumacher, F, Scott, R, Senter, L, Sharma, P, Simard, J, Singer, CF, Sinilnikova, OM, Soucy, P, Southey, M, Steinemann, D, Stenmark-Askmalm, M, Stoppa-Lyonnet, D, Swerdlow, A, Szabo, CI, Tamimi, R, Tapper, W, Teixeira, MR, Teo, S-H, Terry, MB, Thomassen, M, Thompson, D, Tihomirova, L, Toland, AE, Tollenaar, RAEM, Tomlinson, I, Truong, T, Tsimiklis, H, Teule, A, Tumino, R, Tung, N, Turnbull, C, Ursin, G, van Deurzen, CHM, van Rensburg, EJ, Varon-Mateeva, R, Wang, Z, Wang-Gohrke, S, Weiderpass, E, Weitzel, JN, Whittemore, A, Wildiers, H, Winqvist, R, Yang, XR, Yannoukakos, D, Yao, S, Zamora, MP, Zheng, W, Hall, P, Kraft, P, Vachon, C, Slager, S, Chenevix-Trench, G, Pharoah, PDP, Monteiro, AAN, Garcia-Closas, M, Easton, DF, Antoniou, AC, Couch, FJ, Kuchenbaecker, KB, Michailidou, K, Mendoza-Fandino, GA, Nord, S, Lilyquist, J, Olswold, C, Hallberg, E, Agata, S, Ahsan, H, Aittomaeki, K, Ambrosone, C, Andrulis, IL, Anton-Culver, H, Arndt, V, Arun, BK, Arver, B, Barile, M, Barkardottir, RB, Barrowdale, D, Beckmann, L, Beckmann, MW, Benitez, J, Blank, SV, Blomqvist, C, Bogdanova, NV, Bojesen, SE, Bolla, MK, Bonanni, B, Brauch, H, Brenner, H, Burwinkel, B, Buys, SS, Caldes, T, Caligo, MA, Canzian, F, Carpenter, J, Chang-Claude, J, Chanock, SJ, Chung, WK, Claes, KBM, Cox, A, Cross, SS, Cunningham, JM, Czene, K, Daly, MB, Damiola, F, Darabi, H, de la Hoya, M, Devilee, P, Diez, O, Ding, YC, Dolcetti, R, Domchek, SM, Dorfling, CM, dos-Santos-Silva, I, Dumont, M, Dunning, AM, Eccles, DM, Ehrencrona, H, Ekici, AB, Eliassen, H, Ellis, S, Fasching, PA, Figueroa, J, Flesch-Janys, D, Foersti, A, Fostira, F, Foulkes, WD, Friebel, T, Friedman, E, Frost, D, Gabrielson, M, Gammon, MD, Ganz, PA, Gapstur, SM, Garber, J, Gaudet, MM, Gayther, SA, Gerdes, A-M, Ghoussaini, M, Giles, GG, Glendon, G, Godwin, AK, Goldberg, MS, Goldgar, DE, Gonzalez-Neira, A, Greene, MH, Gronwald, J, Guenel, P, Gunter, M, Haeberle, L, Haiman, CA, Hamann, U, Hansen, TVO, Hart, S, Healey, S, Heikkinen, T, Henderson, BE, Herzog, J, Hogervorst, FBL, Hollestelle, A, Hooning, MJ, Hoover, RN, Hopper, JL, Humphreys, K, Hunter, DJ, Huzarski, T, Imyanitov, EN, Isaacs, C, Jakubowska, A, James, P, Janavicius, R, Jensen, UB, John, EM, Jones, M, Kabisch, M, Kar, S, Karlan, BY, Khan, S, Khaw, K-T, Kibriya, MG, Knight, JA, Ko, Y-D, Konstantopoulou, I, Kosma, V-M, Kristensen, V, Kwong, A, Laitman, Y, Lambrechts, D, Lazaro, C, Lee, E, Le Marchand, L, Lester, J, Lindblom, A, Lindor, N, Lindstrom, S, Liu, J, Long, J, Lubinski, J, Mai, PL, Makalic, E, Malone, KE, Mannermaa, A, Manoukian, S, Margolin, S, Marme, F, Martens, JWM, McGuffog, L, Meindl, A, Miller, A, Milne, RL, Miron, P, Montagna, M, Mazoyer, S, Mulligan, AM, Muranen, TA, Nathanson, KL, Neuhausen, SL, Nevanlinna, H, Nordestgaard, BG, Nussbaum, RL, Offit, K, Olah, E, Olopade, OI, Olson, JE, Osorio, A, Park, SK, Peeters, PH, Peissel, B, Peterlongo, P, Peto, J, Phelan, CM, Pilarski, R, Poppe, B, Pylkaes, K, Radice, P, Rahman, N, Rantala, J, Rappaport, C, Rennert, G, Richardson, A, Robson, M, Romieu, I, Rudolph, A, Rutgers, EJ, Sanchez, M-J, Santella, RM, Sawyer, EJ, Schmidt, DF, Schmidt, MK, Schmutzler, RK, Schumacher, F, Scott, R, Senter, L, Sharma, P, Simard, J, Singer, CF, Sinilnikova, OM, Soucy, P, Southey, M, Steinemann, D, Stenmark-Askmalm, M, Stoppa-Lyonnet, D, Swerdlow, A, Szabo, CI, Tamimi, R, Tapper, W, Teixeira, MR, Teo, S-H, Terry, MB, Thomassen, M, Thompson, D, Tihomirova, L, Toland, AE, Tollenaar, RAEM, Tomlinson, I, Truong, T, Tsimiklis, H, Teule, A, Tumino, R, Tung, N, Turnbull, C, Ursin, G, van Deurzen, CHM, van Rensburg, EJ, Varon-Mateeva, R, Wang, Z, Wang-Gohrke, S, Weiderpass, E, Weitzel, JN, Whittemore, A, Wildiers, H, Winqvist, R, Yang, XR, Yannoukakos, D, Yao, S, Zamora, MP, Zheng, W, Hall, P, Kraft, P, Vachon, C, Slager, S, Chenevix-Trench, G, Pharoah, PDP, Monteiro, AAN, Garcia-Closas, M, Easton, DF, and Antoniou, AC

Abstract

Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.

Published
2016

37. Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems

Author

Burton, A, Byrnes, G, Stone, J, Tamimi, RM, Heine, J, Vachon, C, Ozmen, V, Pereira, A, Garmendia, ML, Scott, C, Hipwell, JH, Dickens, C, Schuz, J, Aribal, ME, Bertrand, K, Kwong, A, Giles, GG, Hopper, J, Gomez, BP, Pollan, M, Teo, S-H, Mariapun, S, Taib, NAM, Lajous, M, Lopez-Riduara, R, Rice, M, Romieu, I, Flugelman, AA, Ursin, G, Qureshi, S, Ma, H, Lee, E, Sirous, R, Sirous, M, Lee, JW, Kim, J, Salem, D, Kamal, R, Hartman, M, Miao, H, Chia, K-S, Nagata, C, Vinayak, S, Ndumia, R, Van Gils, CH, Wanders, JOP, Peplonska, B, Bukowska, A, Allen, S, Vinnicombe, S, Moss, S, Chiarelli, AM, Linton, L, Maskarinec, G, Yaffe, MJ, Boyd, NF, Dos-Santos-Silva, I, McCormack, VA, Burton, A, Byrnes, G, Stone, J, Tamimi, RM, Heine, J, Vachon, C, Ozmen, V, Pereira, A, Garmendia, ML, Scott, C, Hipwell, JH, Dickens, C, Schuz, J, Aribal, ME, Bertrand, K, Kwong, A, Giles, GG, Hopper, J, Gomez, BP, Pollan, M, Teo, S-H, Mariapun, S, Taib, NAM, Lajous, M, Lopez-Riduara, R, Rice, M, Romieu, I, Flugelman, AA, Ursin, G, Qureshi, S, Ma, H, Lee, E, Sirous, R, Sirous, M, Lee, JW, Kim, J, Salem, D, Kamal, R, Hartman, M, Miao, H, Chia, K-S, Nagata, C, Vinayak, S, Ndumia, R, Van Gils, CH, Wanders, JOP, Peplonska, B, Bukowska, A, Allen, S, Vinnicombe, S, Moss, S, Chiarelli, AM, Linton, L, Maskarinec, G, Yaffe, MJ, Boyd, NF, Dos-Santos-Silva, I, and McCormack, VA

Abstract

BACKGROUND: Inter-women and intra-women comparisons of mammographic density (MD) are needed in research, clinical and screening applications; however, MD measurements are influenced by mammography modality (screen film/digital) and digital image format (raw/processed). We aimed to examine differences in MD assessed on these image types. METHODS: We obtained 1294 pairs of images saved in both raw and processed formats from Hologic and General Electric (GE) direct digital systems and a Fuji computed radiography (CR) system, and 128 screen-film and processed CR-digital pairs from consecutive screening rounds. Four readers performed Cumulus-based MD measurements (n = 3441), with each image pair read by the same reader. Multi-level models of square-root percent MD were fitted, with a random intercept for woman, to estimate processed-raw MD differences. RESULTS: Breast area did not differ in processed images compared with that in raw images, but the percent MD was higher, due to a larger dense area (median 28.5 and 25.4 cm2 respectively, mean √dense area difference 0.44 cm (95% CI: 0.36, 0.52)). This difference in √dense area was significant for direct digital systems (Hologic 0.50 cm (95% CI: 0.39, 0.61), GE 0.56 cm (95% CI: 0.42, 0.69)) but not for Fuji CR (0.06 cm (95% CI: -0.10, 0.23)). Additionally, within each system, reader-specific differences varied in magnitude and direction (p < 0.001). Conversion equations revealed differences converged to zero with increasing dense area. MD differences between screen-film and processed digital on the subsequent screening round were consistent with expected time-related MD declines. CONCLUSIONS: MD was slightly higher when measured on processed than on raw direct digital mammograms. Comparisons of MD on these image formats should ideally control for this non-constant and reader-specific difference.

Published
2016

38. Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

Author

Beck, AH, Guo, Y, Andersen, SW, Shu, X-O, Michailidou, K, Bolla, MK, Wang, Q, Garcia-Closas, M, Milne, RL, Schmidt, MK, Chang-Claude, J, Dunning, A, Bojesen, SE, Ahsan, H, Aittomaki, K, Andrulis, IL, Anton-Culver, H, Arndt, V, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bogdanova, NV, Bonanni, B, Borresen-Dale, A-L, Brand, J, Brauch, H, Brenner, H, Bruening, T, Burwinkel, B, Casey, G, Chenevix-Trench, G, Couch, FJ, Cox, A, Cross, SS, Czene, K, Devilee, P, Doerk, T, Dumont, M, Fasching, PA, Figueroa, J, Flesch-Janys, D, Fletcher, O, Flyger, H, Fostira, F, Gammon, M, Giles, GG, Guenel, P, Haiman, CA, Hamann, U, Hooning, MJ, Hopper, JL, Jakubowska, A, Jasmine, F, Jenkins, M, John, EM, Johnson, N, Jones, ME, Kabisch, M, Kibriya, M, Knight, JA, Koppert, LB, Kosma, V-M, Kristensen, V, Le Marchand, L, Lee, E, Li, J, Lindblom, A, Luben, R, Lubinski, J, Malone, KE, Mannermaa, A, Margolin, S, Marme, F, McLean, C, Meijers-Heijboer, H, Meindl, A, Neuhausen, SL, Nevanlinna, H, Neven, P, Olson, JE, Perez, JIA, Perkins, B, Peterlongo, P, Phillips, K-A, Pylkas, K, Rudolph, A, Santella, R, Sawyer, EJ, Schmutzler, RK, Seynaeve, C, Shah, M, Shrubsole, MJ, Southey, MC, Swerdlow, AJ, Toland, AE, Tomlinson, I, Torres, D, Truong, T, Ursin, G, Van Der Luijt, RB, Verhoef, S, Whittemore, AS, Winqvist, R, Zhao, H, Zhao, S, Hall, P, Simard, J, Kraft, P, Pharoah, P, Hunter, D, Easton, DF, Zheng, W, Beck, AH, Guo, Y, Andersen, SW, Shu, X-O, Michailidou, K, Bolla, MK, Wang, Q, Garcia-Closas, M, Milne, RL, Schmidt, MK, Chang-Claude, J, Dunning, A, Bojesen, SE, Ahsan, H, Aittomaki, K, Andrulis, IL, Anton-Culver, H, Arndt, V, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bogdanova, NV, Bonanni, B, Borresen-Dale, A-L, Brand, J, Brauch, H, Brenner, H, Bruening, T, Burwinkel, B, Casey, G, Chenevix-Trench, G, Couch, FJ, Cox, A, Cross, SS, Czene, K, Devilee, P, Doerk, T, Dumont, M, Fasching, PA, Figueroa, J, Flesch-Janys, D, Fletcher, O, Flyger, H, Fostira, F, Gammon, M, Giles, GG, Guenel, P, Haiman, CA, Hamann, U, Hooning, MJ, Hopper, JL, Jakubowska, A, Jasmine, F, Jenkins, M, John, EM, Johnson, N, Jones, ME, Kabisch, M, Kibriya, M, Knight, JA, Koppert, LB, Kosma, V-M, Kristensen, V, Le Marchand, L, Lee, E, Li, J, Lindblom, A, Luben, R, Lubinski, J, Malone, KE, Mannermaa, A, Margolin, S, Marme, F, McLean, C, Meijers-Heijboer, H, Meindl, A, Neuhausen, SL, Nevanlinna, H, Neven, P, Olson, JE, Perez, JIA, Perkins, B, Peterlongo, P, Phillips, K-A, Pylkas, K, Rudolph, A, Santella, R, Sawyer, EJ, Schmutzler, RK, Seynaeve, C, Shah, M, Shrubsole, MJ, Southey, MC, Swerdlow, AJ, Toland, AE, Tomlinson, I, Torres, D, Truong, T, Ursin, G, Van Der Luijt, RB, Verhoef, S, Whittemore, AS, Winqvist, R, Zhao, H, Zhao, S, Hall, P, Simard, J, Kraft, P, Pharoah, P, Hunter, D, Easton, DF, and Zheng, W

Abstract

BACKGROUND: Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors. METHODS: We applied Mendelian randomization to evaluate the association between BMI and risk of breast cancer occurrence using data from two large breast cancer consortia. We created a weighted BMI genetic score comprising 84 BMI-associated genetic variants to predicted BMI. We evaluated genetically predicted BMI in association with breast cancer risk using individual-level data from the Breast Cancer Association Consortium (BCAC) (cases = 46,325, controls = 42,482). We further evaluated the association between genetically predicted BMI and breast cancer risk using summary statistics from 16,003 cases and 41,335 controls from the Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Project. Because most studies measured BMI after cancer diagnosis, we could not conduct a parallel analysis to adequately evaluate the association of measured BMI with breast cancer risk prospectively. RESULTS: In the BCAC data, genetically predicted BMI was found to be inversely associated with breast cancer risk (odds ratio [OR] = 0.65 per 5 kg/m2 increase, 95% confidence interval [CI]: 0.56-0.75, p = 3.32 × 10-10). The associations were similar for both premenopausal (OR = 0.44, 95% CI:0.31-0.62, p = 9.91 × 10-8) and postmenopausal breast cancer (OR = 0.57, 95% CI: 0.46-0.71, p = 1.88 × 10-8). This association was replicated in the data from the DRIVE consortium (OR = 0.72, 95% CI: 0.60-0.84, p = 1.64 × 10-7). Single marker analyses identified 17 of the 84 BMI-associated single nucleotide polymorphisms (SNPs) in association with breast cancer risk at p < 0.05; for 16 of them, the allele associated with elevated BMI was associated wit

Published
2016

39. Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent

Author

Guo, Y, Andersen, S W, Shu, XO, Michailidou, K, Bolla, MK, Wang, Q, Garcia-Closas, M, Milne, RL, Schmidt, MK (Marjanka), Chang-Claude, J, Dunning, A, Bojesen, SE, Ahsan, H, Aittomaki, K, Andrulis, IL, Anton-Culver, H, Arndt, V, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bogdanova, NV, Bonanni, B, Borresen-Dale, AL, Brand, J, Brauch, H, Brenner, H, Bruning, T, Burwinkel, B, Casey, G, Chenevix-Trench, G, Couch, FJ, Cox, A, Cross, SS, Czene, K, Devilee, P, Dork, T, Dumont, M, Fasching, PA, Figueroa, J, Flesch-Janys, D, Fletcher, O, Flyger, H, Fostira, F, Gammon, M, Giles, GG, Guenel, P, Haiman, CA, Hamann, U, Hooning, Maartje, Hopper, JL, Jakubowska, A, Jasmine, F, Jenkins, M, John, EM, Johnson, N, Jones, ME, Kabisch, M, Kibriya, M, Knight, JA, Koppert, Linetta, Kosma, VM, Kristensen, V, Le Marchand, L, Lee, E, Li, JM, Lindblom, A, Luben, R, Lubinski, J, Malone, KE, Mannermaa, A, Margolin, S, Marme, F, McLean, C, Meijers-Heijboer, H, Meindl, A, Neuhausen, SL, Nevanlinna, H, Neven, P, Olson, JE, Perez, JIA, Perkins, B, Peterlongo, P, Phillips, KA, Pylkas, K, Rudolph, A, Santella, R, Sawyer, EJ, Schmutzler, RK, Seynaeve, Caroline, Shah, M, Shrubsole, MJ, Southey, MC, Swerdlow, AJ, Toland, AE, Tomlinson, I, Torres, D, Truong, T, Ursin, G, van der Luijt, RB, Verhoef, S, Whittemore, AS, Winqvist, R, Zhao, H, Zhao, S L, Hall, P, Simard, J, Kraft, P, Pharoah, P, Hunter, D, Easton, DF, Zheng, W, Guo, Y, Andersen, S W, Shu, XO, Michailidou, K, Bolla, MK, Wang, Q, Garcia-Closas, M, Milne, RL, Schmidt, MK (Marjanka), Chang-Claude, J, Dunning, A, Bojesen, SE, Ahsan, H, Aittomaki, K, Andrulis, IL, Anton-Culver, H, Arndt, V, Beckmann, MW, Beeghly-Fadiel, A, Benitez, J, Bogdanova, NV, Bonanni, B, Borresen-Dale, AL, Brand, J, Brauch, H, Brenner, H, Bruning, T, Burwinkel, B, Casey, G, Chenevix-Trench, G, Couch, FJ, Cox, A, Cross, SS, Czene, K, Devilee, P, Dork, T, Dumont, M, Fasching, PA, Figueroa, J, Flesch-Janys, D, Fletcher, O, Flyger, H, Fostira, F, Gammon, M, Giles, GG, Guenel, P, Haiman, CA, Hamann, U, Hooning, Maartje, Hopper, JL, Jakubowska, A, Jasmine, F, Jenkins, M, John, EM, Johnson, N, Jones, ME, Kabisch, M, Kibriya, M, Knight, JA, Koppert, Linetta, Kosma, VM, Kristensen, V, Le Marchand, L, Lee, E, Li, JM, Lindblom, A, Luben, R, Lubinski, J, Malone, KE, Mannermaa, A, Margolin, S, Marme, F, McLean, C, Meijers-Heijboer, H, Meindl, A, Neuhausen, SL, Nevanlinna, H, Neven, P, Olson, JE, Perez, JIA, Perkins, B, Peterlongo, P, Phillips, KA, Pylkas, K, Rudolph, A, Santella, R, Sawyer, EJ, Schmutzler, RK, Seynaeve, Caroline, Shah, M, Shrubsole, MJ, Southey, MC, Swerdlow, AJ, Toland, AE, Tomlinson, I, Torres, D, Truong, T, Ursin, G, van der Luijt, RB, Verhoef, S, Whittemore, AS, Winqvist, R, Zhao, H, Zhao, S L, Hall, P, Simard, J, Kraft, P, Pharoah, P, Hunter, D, Easton, DF, and Zheng, W

Published
2016

40. Descriptive epidemiology of Kaposi sarcoma in Europe. Report from the RARECARE project

Author

Stiller, C. A, Trama, A., Brewster, D. H., Verne, J., Bouchardy, C., Navarro, C., Chirlaque, M. D., Marcos Gragera, R., Visser, O., Serraino, D., Weiderpass, E., Dei Tos, A. P., Ascoli, V., Zielonk, N., Van Eycken, E., Sundseth, H., Hedelin, G., Bouvier, A. M., Woronoff, A. S., Buemi, A., Tretarre, B., Colonna, M., Bara, S., Ganry, O., Grosclaude, P., Baconnier, S., Holleczek, B., Geissler, J., Wartenberg, M., Tryggvadottir, L., Deady, S., Bellu, F., Ferretti, Stefano, Vercelli, M., Vitarelli, S., Federico, M., Fusco, M., Michiara, M., Giacomin, A., Tumino, R., Mangone, L., Falcini, F., Senatore, G., Budroni, M., Piffer, S., Crocetti, E., La Rosa, F., Tagliabue, G., Zambon, P., Gatta, G., Gronchi, A., Licitra, L., Ruzza, M., Sowe, S., Capocaccia, R., De Angelis, R., Mallone, S., Tavilla, A., England, K., Ursin, G., Rachtan, J., Gozdz, S., Zwierko, M., Bielska Lasota, M., Slowinski, J., Miranda, A., Safaei Diba, C., Primic Zakelj, M., Mateos, A., Bidaurrazaga, J., Torrella Ramos, A., Ardanaz, E., Galceran, J., Martinez Garcia, C., Sanchez Perez, M. J., Melchor, J. M., Adolfsson, J., Lambe, M., Möller, T. R., Ringborg, U., Jundt, G., Usel, M., Ess, S. M., Spitale, A., Konzelmann, I., Lutz, J. M., Coebergh, J. W. W., Otter, R., Siesling, S., van der Zwan, J. M., Schouten, H., Greenberg, D. C., Wilkinson, J., Roche, M., Meechan, D., Lawrence, G., Mackay, J., Gavin, A., Kunkler, I., and White, C.

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Cancer Research, Survival, Epidemiology, Population, Socio-culturale, Kaposi, Bone Sarcoma, Acquired immunodeficiency syndrome (AIDS), medicine, Prevalence, Humans, Rare cancers, education, Sarcoma, Kaposi, ddc:613, Aged, Population-based study, education.field_of_study, Europe, Incidence, Kaposi sarcoma, Female, Middle Aged, Survival Analysis, Oncology, Medicine (all), Classic Kaposi Sarcoma, Relative survival, business.industry, Incidence (epidemiology), Cancer, Sarcoma, medicine.disease, Surgery, business
Abstract

Kaposi sarcoma (KS) is a virus-related malignancy which most frequently arises in skin, though visceral sites can also be involved. Infection with Kaposi sarcoma herpes virus (KSHV or HHV-8) is required for development of KS. Nowadays, most cases worldwide occur in persons who are immunosuppressed, usually because of HIV infection or as a result of therapy to combat rejection of a transplanted organ, but classic Kaposi sarcoma is predominantly a disease of the elderly without apparent immunosuppression. We analyzed 2667 KS incident cases diagnosed during 1995-2002 and registered by 75 population-based European cancer registries contributing to the RARECARE project. Total crude and age-standardized incidence rate was 0.3 per 100,000 per year with an estimated 1642 new cases per year in the EU27 countries. Age-standardized incidence rate was 0.8 per 100,000 in Southern Europe but below 0.3 per 100,000 in all other regions. The elevated rate in southern Europe was attributable to a combination of classic Kaposi sarcoma in some Mediterranean countries and the relatively high incidence of AIDS in several countries. Five-year relative survival for 2000-2002 by the period method was 75%. More than 10,000 persons were estimated to be alive in Europe at the beginning of 2008 with a past diagnosis of KS. The aetiological link with suppressed immunity means that many people alive following diagnosis of KS suffer comorbidity from a pre-existing condition. While KS is a rare cancer, it has a relatively good prognosis and so the number of people affected by it is quite large. Thus it provides a notable example of the importance of networking in diagnosis, therapy and research for rare cancers.

Published
2014

41. Carcinoma of the cervix and tobacco smoking: Collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies - International collaboration of epidemiological studies of cervical cancer

Author

Rajkumar, T., Appleby, P., Beral, V., Berrington, Da, Bull, D., Crossley, B., Green, J., Reeves, G., Sweetland, S., Kjaer, S., Peto, J., Painter, R., Vessey, M., Daling, J., Madeleine, M., Ray, R., Thomas, D., Hutchinson, F., Hererro, R., Ylitalo, N., Bosch, Fx, Castellsague, X., Hammouda, D., Eva Negri, Santos, C., Colin, D., Franceschi, S., Munoz, N., Plummer, M., Dillner, J., Bayo, S., Chaouki, N., Rolon, P., Brinton, L., Hildesheim, A., Lacey, J., Schiffman, M., Stein, L., Hannaford, P., Chichareon, S., Sitas, F., Eluf-Neto, J., La Vecchia, C., Skegg, D., Pike, M., Ursin, G., Ngelangel, C., Farley, T., Meirik, O., Rajkumar T, Appleby P, Beral V, Berrington DA, Bull D, Crossley B, Green J, Reeves G, Sweetland S, Kjaer S, Peto J, Painter R, Vessey M, Daling J, Madeleine M, Ray R, Thomas D, Hutchinson F, Hererro R, Ylitalo N, Bosch FX, Castellsague X, Hammouda D, Negri E, Santos C, Colin D, Franceschi S, Munoz N, Plummer M, Dillner J, Bayo S, Chaouki N, Rolon P, Brinton L, Hildesheim A, Lacey J, Schiffman M, Stein L, Hannaford P, Chichareon S, Sitas F, Eluf-Neto J, La Vecchia C, Skegg D, Pike M, Ursin G, Ngelangel C, Farley T, and Meirik O

Abstract

Tobacco smoking has been classified as a cause of cervical cancer, but the effect of different patterns of smoking on risk is unclear. The International Collaboration of Epidemiological Studies of Cervical Cancer has brought together and combined individual data on 13,541 women with and 23,017 women without cervical carcinoma, from 23 epidemiological studies. Relative risks (RRs) and 95% confidence intervals (CIs) of carcinoma of the cervix in relation to tobacco smoking were calculated with stratification by study, age, sexual partners, age at first intercourse, oral contraceptive use and parity. Current smokers had a significantly increased risk of squamous cell carcinoma of the cervix compared to never smokers (RR = 1.60 (95% CI: 1.48-1.73), p < 0.001). There was increased risk for past smokers also, though to a lesser extent (RR = 1.12 (1.01-1.25)), and there was no clear trend with time since stopping smoking (p-trend = 0.6). There was no association between smoking and adenocarcinoma of the cervix (RR = 0.89 (0.74-1.06) and 0.89 (0.72-1.10) for current and past smokers respectively), and the differences between the RRs for smoking and squamous cell and adenocarcinoma were statistically significant (current smoking p < 0.001 and past smoking p = 0.01). In current smokers, the RR of squamous cell carcinoma increased with increasing number of cigarettes smoked per day and also with younger age at starting smoking (p < 0.001 for each trend), but not with duration of smoking (p-trend = 0.3). Eight of the studies had tested women for cervical HPV-DNA, and in analyses restricted to women who tested positive, there was a significantly increased risk in current compared to never smokers for squamous cell carcinoma (RR = 1.95 (1.43-2.65)), but not for adenocarcinoma (RR = 1.06 (0.14-7.96)). In summary, smokers are at an increased risk of squamous cell but not of adenocarcinoma of the cervix. The risk of squamous cell carcinoma increases in current smokers with the number of cigarettes smoked per day and with younger age at starting smoking. (c) 2005 Wile-y-Liss. Inc. RI Eluf-Neto, Jose/B-2522-2009

Published
2006

43. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Author

Michailidou, K. (Kyriaki), Beesley, J. (Jonathan), Lindstrom, S. (Stephen), Canisius, S. (Sander), Dennis, J. (Joe), Lush, M. (Michael), Maranian, M. (Melanie), Bolla, M.K. (Manjeet), Wang, Q. (Qing), Shah, M. (Mitul), Perkins, B. (Barbara), Czene, K. (Kamila), Eriksson, M. (Mikael), Darabi, H. (Hatef), Brand, J.S. (Judith S.), Bojesen, S.E. (Stig), Nordestgaard, B.G. (Børge), Flyger, H. (Henrik), Nielsen, S.F. (Sune), Rahman, N. (Nazneen), Turnbull, C. (Clare), Fletcher, O. (Olivia), Peto, J. (Julian), Gibson, L.J. (Lorna), Santos Silva, I. (Isabel) dos, Chang-Claude, J. (Jenny), Flesch-Janys, D. (Dieter), Rudolph, A. (Anja), Eilber, U. (Ursula), Behrens, T.W. (Timothy), Nevanlinna, H. (Heli), Muranen, T.A. (Taru), Aittomäki, K. (Kristiina), Blomqvist, C. (Carl), Khan, S. (Sofia), Aaltonen, K. (Kirsimari), Ahsan, H. (Habibul), Kibriya, M.G. (Muhammad), Whittemore, A.S. (Alice S.), John, E.M. (Esther M.), Malone, K.E. (Kathleen E.), Gammon, M.D. (Marilie), Santella, R.M. (Regina M.), Ursin, G. (Giske), Makalic, E. (Enes), Schmidt, D.F. (Daniel), Casey, G. (Graham), Hunter, D.J. (David J.), Gapstur, S.M. (Susan M.), Gaudet, M.M. (Mia), Diver, W.R. (Ryan), Haiman, C.A. (Christopher A.), Schumacher, F.R. (Fredrick), Henderson, B.E. (Brian), Le Marchand, L. (Loic), Berg, C.D. (Christine), Chanock, S.J. (Stephen), Figueroa, J.D. (Jonine), Hoover, R.N. (Robert N.), Lambrechts, D. (Diether), Neven, P. (Patrick), Wildiers, H. (Hans), Limbergen, E. (Erik) van, Schmidt, M.K. (Marjanka), Broeks, A. (Annegien), Verhoef, S., Cornelissen, S. (Sten), Couch, F.J. (Fergus), Olson, J.E. (Janet), Hallberg, B. (Boubou), Vachon, C. (Celine), Waisfisz, Q. (Quinten), Meijers-Heijboer, E.J. (Hanne), Adank, M.A. (Muriel), Luijt, R.B. (Rob) van der, Li, J. (Jingmei), Liu, J. (Jianjun), Humphreys, M.K. (Manjeet), Kang, D. (Daehee), Choi, J.-Y. (Ji-Yeob), Park, S.K. (Sue K.), Yoo, K.Y., Matsuo, K. (Keitaro), Ito, H. (Hidemi), Iwata, H. (Hiroji), Tajima, K. (Kazuo), Guénel, P. (Pascal), Truong, T. (Thérèse), Mulot, C. (Claire), Sanchez, M. (Marie), Burwinkel, B. (Barbara), Marme, F. (Federick), Surowy, H. (Harald), Sohn, C. (Christof), Wu, A.H. (Anna H), Tseng, C.-C. (Chiu-chen), Van Den Berg, D. (David), Stram, D.O. (Daniel O.), González-Neira, A. (Anna), Benítez, J. (Javier), Zamora, M.P. (Pilar), Perez, J.I.A. (Jose Ignacio Arias), Shu, X.-O. (Xiao-Ou), Lu, W. (Wei), Gao, Y. (Ying), Cai, H. (Hui), Cox, A. (Angela), Cross, S.S. (Simon), Reed, M.W.R. (Malcolm), Andrulis, I.L. (Irene), Knight, J.A. (Julia), Glendon, G. (Gord), Mulligan, A.-M. (Anna-Marie), Sawyer, E.J. (Elinor), Tomlinson, I.P. (Ian), Kerin, M. (Michael), Miller, N. (Nicola), Lindblom, A. (Annika), Margolin, S. (Sara), Teo, S.H. (Soo Hwang), Yip, C.H. (Cheng Har), Taib, N.A.M. (Nur Aishah Mohd), Tan, G.-H. (Gie-Hooi), Hooning, M.J. (Maartje), Hollestelle, A. (Antoinette), Martens, J.W.M. (John), Collée, J.M. (Margriet), Blot, W.J. (William), Signorello, L.B. (Lisa B.), Cai, Q. (Qiuyin), Hopper, J. (John), Southey, M.C. (Melissa), Tsimiklis, H. (Helen), Apicella, C. (Carmel), Shen, C-Y. (Chen-Yang), Hsiung, C.-N. (Chia-Ni), Wu, P.-E. (Pei-Ei), Hou, M.-F. (Ming-Feng), Kristensen, V. (Vessela), Nord, S. (Silje), Alnæs, G.G. (Grethe), Giles, G.G. (Graham G.), Milne, R.L. (Roger), McLean, C.A. (Catriona Ann), Canzian, F. (Federico), Trichopoulos, D. (Dimitrios), Peeters, P.H.M., Lund, E. (Eiliv), Sund, R. (Reijo), Khaw, K.T., Gunter, M.J. (Marc J.), Palli, D. (Domenico), Mortensen, L.M. (Lotte Maxild), Dossus, L. (Laure), Huerta, J.-M. (Jose-Maria), Meindl, A. (Alfons), Schmutzler, R.K. (Rita), Sutter, C. (Christian), Yang, R. (Rongxi), Muir, K. (Kenneth), Lophatananon, A. (Artitaya), Stewart-Brown, S. (Sarah), Siriwanarangsan, P. (Pornthep), Hartman, J.M. (Joost), Miao, X., Chia, K.S. (Kee Seng), Chan, C.W. (Ching Wan), Fasching, P.A. (Peter), Hein, R. (Rebecca), Beckmann, M.W. (Matthias), Haeberle, L. (Lothar), Brenner, H. (Hermann), Dieffenbach, A.K. (Aida Karina), Arndt, V. (Volker), Stegmaier, C. (Christa), Ashworth, A. (Alan), Orr, N. (Nick), Schoemaker, M. (Minouk), Swerdlow, A.J. (Anthony ), Brinton, L.A. (Louise), García-Closas, M. (Montserrat), Zheng, W. (Wei), Halverson, S.L. (Sandra L.), Shrubsole, M. (Martha), Long, J. (Jirong), Goldberg, M.S. (Mark), Labrèche, F. (France), Dumont, M. (Martine), Winqvist, R. (Robert), Pykäs, K. (Katri), Jukkola-Vuorinen, A. (Arja), Grip, M. (Mervi), Brauch, H. (Hiltrud), Hamann, U. (Ute), Brüning, T. (Thomas), Radice, P. (Paolo), Peterlongo, P. (Paolo), Manoukian, S. (Siranoush), Bernard, L. (Loris), Bogdanova, N.V. (Natalia), Dörk, T. (Thilo), Mannermaa, A. (Arto), Kataja, V. (Vesa), Kosma, V-M. (Veli-Matti), Hartikainen, J.M. (J.), Devilee, P. (Peter), Tollenaar, R.A.E.M. (Rob), Seynaeve, C.M. (Caroline), Asperen, C.J. (Christi) van, Jakubowska, A. (Anna), Lubinski, J. (Jan), Jaworska, K. (Katarzyna), Huzarski, T. (Tomasz), Sangrajrang, S. (Suleeporn), Gaborieau, V. (Valerie), Brennan, P. (Paul), McKay, J.D. (James), Slager, S. (Susan), Toland, A.E. (Amanda), Ambrosone, C.B. (Christine), Yannoukakos, D. (Drakoulis), Kabisch, M. (Maria), Torres, D. (Diana), Neuhausen, S.L. (Susan), Anton-Culver, H. (Hoda), Luccarini, C. (Craig), Baynes, C. (Caroline), Ahmed, S. (Shahana), Healey, S. (Sue), Tessier, D.C. (Daniel C.), Vincent, D. (Daniel), Bacot, F. (Francois), Pita, G. (Guillermo), Alonso, M.R. (Rosario), Álvarez, N. (Nuria), Herrero, D. (Daniel), Simard, J. (Jacques), Pharoah, P.P.D.P. (Paul P.D.P.), Kraft, P. (Peter), Dunning, A.M. (Alison), Chenevix-Trench, G. (Georgia), Hall, P. (Per), Easton, D.F. (Douglas), Michailidou, K. (Kyriaki), Beesley, J. (Jonathan), Lindstrom, S. (Stephen), Canisius, S. (Sander), Dennis, J. (Joe), Lush, M. (Michael), Maranian, M. (Melanie), Bolla, M.K. (Manjeet), Wang, Q. (Qing), Shah, M. (Mitul), Perkins, B. (Barbara), Czene, K. (Kamila), Eriksson, M. (Mikael), Darabi, H. (Hatef), Brand, J.S. (Judith S.), Bojesen, S.E. (Stig), Nordestgaard, B.G. (Børge), Flyger, H. (Henrik), Nielsen, S.F. (Sune), Rahman, N. (Nazneen), Turnbull, C. (Clare), Fletcher, O. (Olivia), Peto, J. (Julian), Gibson, L.J. (Lorna), Santos Silva, I. (Isabel) dos, Chang-Claude, J. (Jenny), Flesch-Janys, D. (Dieter), Rudolph, A. (Anja), Eilber, U. (Ursula), Behrens, T.W. (Timothy), Nevanlinna, H. (Heli), Muranen, T.A. (Taru), Aittomäki, K. (Kristiina), Blomqvist, C. (Carl), Khan, S. (Sofia), Aaltonen, K. (Kirsimari), Ahsan, H. (Habibul), Kibriya, M.G. (Muhammad), Whittemore, A.S. (Alice S.), John, E.M. (Esther M.), Malone, K.E. (Kathleen E.), Gammon, M.D. (Marilie), Santella, R.M. (Regina M.), Ursin, G. (Giske), Makalic, E. (Enes), Schmidt, D.F. (Daniel), Casey, G. (Graham), Hunter, D.J. (David J.), Gapstur, S.M. (Susan M.), Gaudet, M.M. (Mia), Diver, W.R. (Ryan), Haiman, C.A. (Christopher A.), Schumacher, F.R. (Fredrick), Henderson, B.E. (Brian), Le Marchand, L. (Loic), Berg, C.D. (Christine), Chanock, S.J. (Stephen), Figueroa, J.D. (Jonine), Hoover, R.N. (Robert N.), Lambrechts, D. (Diether), Neven, P. (Patrick), Wildiers, H. (Hans), Limbergen, E. (Erik) van, Schmidt, M.K. (Marjanka), Broeks, A. (Annegien), Verhoef, S., Cornelissen, S. (Sten), Couch, F.J. (Fergus), Olson, J.E. (Janet), Hallberg, B. (Boubou), Vachon, C. (Celine), Waisfisz, Q. (Quinten), Meijers-Heijboer, E.J. (Hanne), Adank, M.A. (Muriel), Luijt, R.B. (Rob) van der, Li, J. (Jingmei), Liu, J. (Jianjun), Humphreys, M.K. (Manjeet), Kang, D. (Daehee), Choi, J.-Y. (Ji-Yeob), Park, S.K. (Sue K.), Yoo, K.Y., Matsuo, K. (Keitaro), Ito, H. (Hidemi), Iwata, H. (Hiroji), Tajima, K. (Kazuo), Guénel, P. (Pascal), Truong, T. (Thérèse), Mulot, C. (Claire), Sanchez, M. (Marie), Burwinkel, B. (Barbara), Marme, F. (Federick), Surowy, H. (Harald), Sohn, C. (Christof), Wu, A.H. (Anna H), Tseng, C.-C. (Chiu-chen), Van Den Berg, D. (David), Stram, D.O. (Daniel O.), González-Neira, A. (Anna), Benítez, J. (Javier), Zamora, M.P. (Pilar), Perez, J.I.A. (Jose Ignacio Arias), Shu, X.-O. (Xiao-Ou), Lu, W. (Wei), Gao, Y. (Ying), Cai, H. (Hui), Cox, A. (Angela), Cross, S.S. (Simon), Reed, M.W.R. (Malcolm), Andrulis, I.L. (Irene), Knight, J.A. (Julia), Glendon, G. (Gord), Mulligan, A.-M. (Anna-Marie), Sawyer, E.J. (Elinor), Tomlinson, I.P. (Ian), Kerin, M. (Michael), Miller, N. (Nicola), Lindblom, A. (Annika), Margolin, S. (Sara), Teo, S.H. (Soo Hwang), Yip, C.H. (Cheng Har), Taib, N.A.M. (Nur Aishah Mohd), Tan, G.-H. (Gie-Hooi), Hooning, M.J. (Maartje), Hollestelle, A. (Antoinette), Martens, J.W.M. (John), Collée, J.M. (Margriet), Blot, W.J. (William), Signorello, L.B. (Lisa B.), Cai, Q. (Qiuyin), Hopper, J. (John), Southey, M.C. (Melissa), Tsimiklis, H. (Helen), Apicella, C. (Carmel), Shen, C-Y. (Chen-Yang), Hsiung, C.-N. (Chia-Ni), Wu, P.-E. (Pei-Ei), Hou, M.-F. (Ming-Feng), Kristensen, V. (Vessela), Nord, S. (Silje), Alnæs, G.G. (Grethe), Giles, G.G. (Graham G.), Milne, R.L. (Roger), McLean, C.A. (Catriona Ann), Canzian, F. (Federico), Trichopoulos, D. (Dimitrios), Peeters, P.H.M., Lund, E. (Eiliv), Sund, R. (Reijo), Khaw, K.T., Gunter, M.J. (Marc J.), Palli, D. (Domenico), Mortensen, L.M. (Lotte Maxild), Dossus, L. (Laure), Huerta, J.-M. (Jose-Maria), Meindl, A. (Alfons), Schmutzler, R.K. (Rita), Sutter, C. (Christian), Yang, R. (Rongxi), Muir, K. (Kenneth), Lophatananon, A. (Artitaya), Stewart-Brown, S. (Sarah), Siriwanarangsan, P. (Pornthep), Hartman, J.M. (Joost), Miao, X., Chia, K.S. (Kee Seng), Chan, C.W. (Ching Wan), Fasching, P.A. (Peter), Hein, R. (Rebecca), Beckmann, M.W. (Matthias), Haeberle, L. (Lothar), Brenner, H. (Hermann), Dieffenbach, A.K. (Aida Karina), Arndt, V. (Volker), Stegmaier, C. (Christa), Ashworth, A. (Alan), Orr, N. (Nick), Schoemaker, M. (Minouk), Swerdlow, A.J. (Anthony ), Brinton, L.A. (Louise), García-Closas, M. (Montserrat), Zheng, W. (Wei), Halverson, S.L. (Sandra L.), Shrubsole, M. (Martha), Long, J. (Jirong), Goldberg, M.S. (Mark), Labrèche, F. (France), Dumont, M. (Martine), Winqvist, R. (Robert), Pykäs, K. (Katri), Jukkola-Vuorinen, A. (Arja), Grip, M. (Mervi), Brauch, H. (Hiltrud), Hamann, U. (Ute), Brüning, T. (Thomas), Radice, P. (Paolo), Peterlongo, P. (Paolo), Manoukian, S. (Siranoush), Bernard, L. (Loris), Bogdanova, N.V. (Natalia), Dörk, T. (Thilo), Mannermaa, A. (Arto), Kataja, V. (Vesa), Kosma, V-M. (Veli-Matti), Hartikainen, J.M. (J.), Devilee, P. (Peter), Tollenaar, R.A.E.M. (Rob), Seynaeve, C.M. (Caroline), Asperen, C.J. (Christi) van, Jakubowska, A. (Anna), Lubinski, J. (Jan), Jaworska, K. (Katarzyna), Huzarski, T. (Tomasz), Sangrajrang, S. (Suleeporn), Gaborieau, V. (Valerie), Brennan, P. (Paul), McKay, J.D. (James), Slager, S. (Susan), Toland, A.E. (Amanda), Ambrosone, C.B. (Christine), Yannoukakos, D. (Drakoulis), Kabisch, M. (Maria), Torres, D. (Diana), Neuhausen, S.L. (Susan), Anton-Culver, H. (Hoda), Luccarini, C. (Craig), Baynes, C. (Caroline), Ahmed, S. (Shahana), Healey, S. (Sue), Tessier, D.C. (Daniel C.), Vincent, D. (Daniel), Bacot, F. (Francois), Pita, G. (Guillermo), Alonso, M.R. (Rosario), Álvarez, N. (Nuria), Herrero, D. (Daniel), Simard, J. (Jacques), Pharoah, P.P.D.P. (Paul P.D.P.), Kraft, P. (Peter), Dunning, A.M. (Alison), Chenevix-Trench, G. (Georgia), Hall, P. (Per), and Easton, D.F. (Douglas)

Abstract

Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10 â '8. Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.

Published
2015
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44. Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Author

Michailidou, K, Beesley, J, Lindstrom, S, Canisius, S, Dennis, J, Lush, MJ, Maranian, MJ, Bolla, MK, Wang, Q, Shah, M, Perkins, BJ, Czene, K, Eriksson, M, Darabi, H, Brand, JS, Bojesen, SE, Nordestgaard, BG, Flyger, H, Nielsen, SF, Rahman, N, Turnbull, C, Fletcher, O, Peto, J, Gibson, L, dos-Santos-Silva, I, Chang-Claude, J, Flesch-Janys, D, Rudolph, A, Eilber, U, Behrens, S, Nevanlinna, H, Muranen, TA, Aittomaki, K, Blomqvist, C, Khan, S, Aaltonen, K, Ahsan, H, Kibriya, MG, Whittemore, AS, John, EM, Malone, KE, Gammon, MD, Santella, RM, Ursin, G, Makalic, E, Schmidt, DF, Casey, G, Hunter, DJ, Gapstur, SM, Gaudet, MM, Diver, WR, Haiman, CA, Schumacher, F, Henderson, BE, Le Marchand, L, Berg, CD, Chanock, SJ, Figueroa, J, Hoover, RN, Lambrechts, D, Neven, P, Wildiers, H, van Limbergen, E, Schmidt, MK, Broeks, A, Verhoef, S, Cornelissen, S, Couch, FJ, Olson, JE, Hallberg, E, Vachon, C, Waisfisz, Q, Meijers-Heijboer, H, Adank, MA, van der Luijt, RB, Li, J, Liu, J, Humphreys, K, Kang, D, Choi, J-Y, Park, SK, Yoo, K-Y, Matsuo, K, Ito, H, Iwata, H, Tajima, K, Guenel, P, Truong, T, Mulot, C, Sanchez, M, Burwinkel, B, Marme, F, Surowy, H, Sohn, C, Wu, AH, Tseng, C-C, Van den Berg, D, Stram, DO, Gonzalez-Neira, A, Benitez, J, Zamora, MP, Arias Perez, JI, Shu, X-O, Lu, W, Gao, Y-T, Cai, H, Cox, A, Cross, SS, Reed, MWR, Andrulis, IL, Knight, JA, Glendon, G, Mulligan, AM, Sawyer, EJ, Tomlinson, I, Kerin, MJ, Miller, N, Lindblom, A, Margolin, S, Teo, SH, Yip, CH, Taib, NAM, Tan, G-H, Hooning, MJ, Hollestelle, A, Martens, JWM, Collee, JM, Blot, W, Signorello, LB, Cai, Q, Hopper, JL, Southey, MC, Tsimiklis, H, Apicella, C, Shen, C-Y, Hsiung, C-N, Wu, P-E, Hou, M-F, Kristensen, VN, Nord, S, Alnaes, GIG, Giles, GG, Milne, RL, McLean, C, Canzian, F, Trichopoulos, D, Peeters, P, Lund, E, Sund, M, Khaw, K-T, Gunter, MJ, Palli, D, Mortensen, LM, Dossus, L, Huerta, J-M, Meindl, A, Schmutzler, RK, Sutter, C, Yang, R, Muir, K, Lophatananon, A, Stewart-Brown, S, Siriwanarangsan, P, Hartman, M, Miao, H, Chia, KS, Chan, CW, Fasching, PA, Hein, A, Beckmann, MW, Haeberle, L, Brenner, H, Dieffenbach, AK, Arndt, V, Stegmaier, C, Ashworth, A, Orr, N, Schoemaker, MJ, Swerdlow, AJ, Brinton, L, Garcia-Closas, M, Zheng, W, Halverson, SL, Shrubsole, M, Long, J, Goldberg, MS, Labreche, F, Dumont, M, Winqvist, R, Pylkas, K, Jukkola-Vuorinen, A, Grip, M, Brauch, H, Hamann, U, Bruening, T, Radice, P, Peterlongo, P, Manoukian, S, Bernard, L, Bogdanova, NV, Doerk, T, Mannermaa, A, Kataja, V, Kosma, V-M, Hartikainen, JM, Devilee, P, Tollenaar, RAEM, Seynaeve, C, Van Asperen, CJ, Jakubowska, A, Lubinski, J, Jaworska, K, Huzarski, T, Sangrajrang, S, Gaborieau, V, Brennan, P, Mckay, J, Slager, S, Toland, AE, Ambrosone, CB, Yannoukakos, D, Kabisch, M, Torres, D, Neuhausen, SL, Anton-Culver, H, Luccarini, C, Baynes, C, Ahmed, S, Healey, CS, Tessier, DC, Vincent, D, Bacot, F, Pita, G, Rosario Alonso, M, Alvarez, N, Herrero, D, Simard, J, Pharoah, PPDP, Kraft, P, Dunning, AM, Chenevix-Trench, G, Hall, P, Easton, DF, Michailidou, K, Beesley, J, Lindstrom, S, Canisius, S, Dennis, J, Lush, MJ, Maranian, MJ, Bolla, MK, Wang, Q, Shah, M, Perkins, BJ, Czene, K, Eriksson, M, Darabi, H, Brand, JS, Bojesen, SE, Nordestgaard, BG, Flyger, H, Nielsen, SF, Rahman, N, Turnbull, C, Fletcher, O, Peto, J, Gibson, L, dos-Santos-Silva, I, Chang-Claude, J, Flesch-Janys, D, Rudolph, A, Eilber, U, Behrens, S, Nevanlinna, H, Muranen, TA, Aittomaki, K, Blomqvist, C, Khan, S, Aaltonen, K, Ahsan, H, Kibriya, MG, Whittemore, AS, John, EM, Malone, KE, Gammon, MD, Santella, RM, Ursin, G, Makalic, E, Schmidt, DF, Casey, G, Hunter, DJ, Gapstur, SM, Gaudet, MM, Diver, WR, Haiman, CA, Schumacher, F, Henderson, BE, Le Marchand, L, Berg, CD, Chanock, SJ, Figueroa, J, Hoover, RN, Lambrechts, D, Neven, P, Wildiers, H, van Limbergen, E, Schmidt, MK, Broeks, A, Verhoef, S, Cornelissen, S, Couch, FJ, Olson, JE, Hallberg, E, Vachon, C, Waisfisz, Q, Meijers-Heijboer, H, Adank, MA, van der Luijt, RB, Li, J, Liu, J, Humphreys, K, Kang, D, Choi, J-Y, Park, SK, Yoo, K-Y, Matsuo, K, Ito, H, Iwata, H, Tajima, K, Guenel, P, Truong, T, Mulot, C, Sanchez, M, Burwinkel, B, Marme, F, Surowy, H, Sohn, C, Wu, AH, Tseng, C-C, Van den Berg, D, Stram, DO, Gonzalez-Neira, A, Benitez, J, Zamora, MP, Arias Perez, JI, Shu, X-O, Lu, W, Gao, Y-T, Cai, H, Cox, A, Cross, SS, Reed, MWR, Andrulis, IL, Knight, JA, Glendon, G, Mulligan, AM, Sawyer, EJ, Tomlinson, I, Kerin, MJ, Miller, N, Lindblom, A, Margolin, S, Teo, SH, Yip, CH, Taib, NAM, Tan, G-H, Hooning, MJ, Hollestelle, A, Martens, JWM, Collee, JM, Blot, W, Signorello, LB, Cai, Q, Hopper, JL, Southey, MC, Tsimiklis, H, Apicella, C, Shen, C-Y, Hsiung, C-N, Wu, P-E, Hou, M-F, Kristensen, VN, Nord, S, Alnaes, GIG, Giles, GG, Milne, RL, McLean, C, Canzian, F, Trichopoulos, D, Peeters, P, Lund, E, Sund, M, Khaw, K-T, Gunter, MJ, Palli, D, Mortensen, LM, Dossus, L, Huerta, J-M, Meindl, A, Schmutzler, RK, Sutter, C, Yang, R, Muir, K, Lophatananon, A, Stewart-Brown, S, Siriwanarangsan, P, Hartman, M, Miao, H, Chia, KS, Chan, CW, Fasching, PA, Hein, A, Beckmann, MW, Haeberle, L, Brenner, H, Dieffenbach, AK, Arndt, V, Stegmaier, C, Ashworth, A, Orr, N, Schoemaker, MJ, Swerdlow, AJ, Brinton, L, Garcia-Closas, M, Zheng, W, Halverson, SL, Shrubsole, M, Long, J, Goldberg, MS, Labreche, F, Dumont, M, Winqvist, R, Pylkas, K, Jukkola-Vuorinen, A, Grip, M, Brauch, H, Hamann, U, Bruening, T, Radice, P, Peterlongo, P, Manoukian, S, Bernard, L, Bogdanova, NV, Doerk, T, Mannermaa, A, Kataja, V, Kosma, V-M, Hartikainen, JM, Devilee, P, Tollenaar, RAEM, Seynaeve, C, Van Asperen, CJ, Jakubowska, A, Lubinski, J, Jaworska, K, Huzarski, T, Sangrajrang, S, Gaborieau, V, Brennan, P, Mckay, J, Slager, S, Toland, AE, Ambrosone, CB, Yannoukakos, D, Kabisch, M, Torres, D, Neuhausen, SL, Anton-Culver, H, Luccarini, C, Baynes, C, Ahmed, S, Healey, CS, Tessier, DC, Vincent, D, Bacot, F, Pita, G, Rosario Alonso, M, Alvarez, N, Herrero, D, Simard, J, Pharoah, PPDP, Kraft, P, Dunning, AM, Chenevix-Trench, G, Hall, P, and Easton, DF

Abstract

Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ∼14% of the familial risk of the disease. To identify new susceptibility loci, we performed a meta-analysis of 11 GWAS, comprising 15,748 breast cancer cases and 18,084 controls together with 46,785 cases and 42,892 controls from 41 studies genotyped on a 211,155-marker custom array (iCOGS). Analyses were restricted to women of European ancestry. We generated genotypes for more than 11 million SNPs by imputation using the 1000 Genomes Project reference panel, and we identified 15 new loci associated with breast cancer at P < 5 × 10(-8). Combining association analysis with ChIP-seq chromatin binding data in mammary cell lines and ChIA-PET chromatin interaction data from ENCODE, we identified likely target genes in two regions: SETBP1 at 18q12.3 and RNF115 and PDZK1 at 1q21.1. One association appears to be driven by an amino acid substitution encoded in EXO1.

Published
2015

45. Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study

Author

Zhang, C, Doherty, JA, Burgess, S, Hung, RJ, Lindstroem, S, Kraft, P, Gong, J, Amos, CI, Sellers, TA, Monteiro, ANA, Chenevix-Trench, G, Bickeboeller, H, Risch, A, Brennan, P, Mckay, JD, Houlston, RS, Landi, MT, Timofeeva, MN, Wang, Y, Heinrich, J, Kote-Jarai, Z, Eeles, RA, Muir, K, Wiklund, F, Gronberg, H, Berndt, SI, Chanock, SJ, Schumacher, F, Haiman, CA, Henderson, BE, Al Olama, AA, Andrulis, IL, Hopper, JL, Chang-Claude, J, John, EM, Malone, KE, Gammon, MD, Ursin, G, Whittemore, AS, Hunter, DJ, Gruber, SB, Knight, JA, Hou, L, Le Marchand, L, Newcomb, PA, Hudson, TJ, Chan, AT, Li, L, Woods, MO, Ahsan, H, Pierce, BL, Zhang, C, Doherty, JA, Burgess, S, Hung, RJ, Lindstroem, S, Kraft, P, Gong, J, Amos, CI, Sellers, TA, Monteiro, ANA, Chenevix-Trench, G, Bickeboeller, H, Risch, A, Brennan, P, Mckay, JD, Houlston, RS, Landi, MT, Timofeeva, MN, Wang, Y, Heinrich, J, Kote-Jarai, Z, Eeles, RA, Muir, K, Wiklund, F, Gronberg, H, Berndt, SI, Chanock, SJ, Schumacher, F, Haiman, CA, Henderson, BE, Al Olama, AA, Andrulis, IL, Hopper, JL, Chang-Claude, J, John, EM, Malone, KE, Gammon, MD, Ursin, G, Whittemore, AS, Hunter, DJ, Gruber, SB, Knight, JA, Hou, L, Le Marchand, L, Newcomb, PA, Hudson, TJ, Chan, AT, Li, L, Woods, MO, Ahsan, H, and Pierce, BL

Abstract

Epidemiological studies have reported inconsistent associations between telomere length (TL) and risk for various cancers. These inconsistencies are likely attributable, in part, to biases that arise due to post-diagnostic and post-treatment TL measurement. To avoid such biases, we used a Mendelian randomization approach and estimated associations between nine TL-associated SNPs and risk for five common cancer types (breast, lung, colorectal, ovarian and prostate cancer, including subtypes) using data on 51 725 cases and 62 035 controls. We then used an inverse-variance weighted average of the SNP-specific associations to estimate the association between a genetic score representing long TL and cancer risk. The long TL genetic score was significantly associated with increased risk of lung adenocarcinoma (P = 6.3 × 10(-15)), even after exclusion of a SNP residing in a known lung cancer susceptibility region (TERT-CLPTM1L) P = 6.6 × 10(-6)). Under Mendelian randomization assumptions, the association estimate [odds ratio (OR) = 2.78] is interpreted as the OR for lung adenocarcinoma corresponding to a 1000 bp increase in TL. The weighted TL SNP score was not associated with other cancer types or subtypes. Our finding that genetic determinants of long TL increase lung adenocarcinoma risk avoids issues with reverse causality and residual confounding that arise in observational studies of TL and disease risk. Under Mendelian randomization assumptions, our finding suggests that longer TL increases lung adenocarcinoma risk. However, caution regarding this causal interpretation is warranted in light of the potential issue of pleiotropy, and a more general interpretation is that SNPs influencing telomere biology are also implicated in lung adenocarcinoma risk.

Published
2015

47. Rare neuroendocrine tumours: Results of the surveillance of rare cancers in Europe project

Author

Van Der Zwan, Jan Maarten, Trama, Annalisa, Otter, Renã©e, Larraã±aga, Nerea, Tavilla, Andrea, Marcos-gragera, Rafael, Dei Tos, Angelo Paolo, Baudin, Eric, Poston, Graeme, Links, Thera, Zielonke, N., Van Eycken, E., Sundseth, H., Hedelin, G., Faivre, JULIEN YVES STEPHAN, Woronoff, A. S., Buemi, A., Tretarre, B., Colonna, Marco, Bara, S., Ganry, O., Grosclaude, P., Holleczek, B., Geissler, J., Tryggvadottir, L., Deady, S., Bellã¹, F., Ferretti, Silvia, Serraino, D., Vercelli, M., Vitarelli, S., Cirilli, C., Fusco, M., Traina, Angelo, Michiara, M., Giacomin, A., Tumino, R., Mangone, L., Falcini, F., Senatore, G., Budroni, M., Piffer, S., Crocetti, E., LA ROSA, FEDERICA IRENE, Contiero, P., Fiore, A., Gatta, G., Casali, P. G., Gronchi, A., Ruzza, Marta, Sowe, S., De Angelis, R., Dei Tos, A. P., England, K., Ursin, G., Rachtan, J., Gozdz, S., Zwierko, M., Slowinski, J., Miranda, A., Safaei Diba, C., Primic-zakelj, M., Mateos, A., Martã­nez, R., Torrella-ramos, A., Osca-gelis, G., Chirlaque, M. D., Moreno, C., Galceran, J., Martinez-garcia, C., Melchor, J. M., Sã¡nchez, M. J., Virizuela-echaburu, J. A., Cervantes, A., Adolfsson, J., Lambe, M., Mã¶ller, T. R., Ringborg, U., Jundt, G., Bouchardy, C., Ess, S. M., Bordoni, A., Konzelmann, I., Lutz, J. M., Visser, O., Siesling, S., Coebergh, J. W. W., Greenberg, D. C., Wilkinson, Robert John Duncan, Roche, M., Verne, J., Meechan, D., Lawrence, G., Coleman, M. P., Mackay, J., Gavin, A., Brewster, D. H., Kunkler, I., White, C., Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), and Bouchardy Magnin, Christine

Subjects
Male, Pediatrics, Pathology, Cancer Research, MEDULLARY-THYROID CARCINOMA, Survival, Rare Diseases/epidemiology/mortality, Neuroendocrine Tumors/epidemiology/mortality, PROGNOSTIC-FACTORS, MERKEL CELL-CARCINOMA, Prevalence, EPIDEMIOLOGY, Cancer registry, Incidence, Prevalence, Survival, Neuroendocrine, Registries, Child, education.field_of_study, Relative survival, Merkel cell carcinoma, Incidence (epidemiology), Incidence, Middle Aged, Cancer registry, Europe, Neuroendocrine Tumors, Neuroendocrine, Oncology, Child, Preschool, Epidemiological Monitoring, Female, Adult, medicine.medical_specialty, Adolescent, Population, UNITED-STATES, DIAGNOSIS, Europe/epidemiology, NO, PERIOD ANALYSIS, Young Adult, Rare Diseases, Carcinoma, medicine, Rare neuroendocrine tumours, Humans, education, Survival analysis, ddc:613, Aged, business.industry, Infant, Newborn, Cancer, Infant, NATURAL-HISTORY, medicine.disease, Survival Analysis, STAGING-SYSTEMS, business
Abstract

Because of the low incidence, and limited opportunities for large patient volume experiences, there are very few relevant studies of neuroendocrine tumours (NETs).A large population-based database (including cancer patients diagnosed from 1978 to 2002 and registered in 76 population-based cancer registries [CRs]), provided by the project 'surveillance of rare cancers in Europe' (RARECARE) is used to describe the basic indicators of incidence, prevalence and survival of NETs, giving a unique overview on the burden of NETs in Europe. NETs at all cancer sites, excluding lung, were analysed in this study. In total over 20,000 incident cases of NETs were analysed and a data quality check upon specific NETs was performed. The overall incidence rate for NETs was 25/1,000,000 and was highest in patients aged 65 years and older with well differentiated endocrine carcinomas (non-functioning pancreatic and gastrointestinal) (40 per 1,000,000). We estimated that slightly more than 100,000 people were diagnosed with NETs and still alive in EU27 at the beginning of 2008. Overall, NETs had a 5 year relative survival of 50%; survival was low (12%) for poorly differentiated endocrine carcinoma, and relatively high (64%) for well differentiated carcinoma (not functioning of the pancreas and digestive organs). Within NETs, endocrine carcinoma of thyroid gland had the best 5-year relative survival (82%).Because of the complexity and number of the different disciplines involved with NETs (as they arise in many organs), a multidisciplinary approach delivered in highly qualified reference centres and an international network between those centres is recommended. (c) 2013 Elsevier Ltd. All rights reserved.

Published
2013

48. Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease

Author

Peterson, B., Ontiveros, P., Yu, M. C., Heath, C. W., Bergkvist, L., Baines, C. J., Malone, K., Magnusson, C., Lubin, F., Kungu, A., Kay, C., Pike, M., Siskind, V., Virutamasen, P., Hermon, C., Brêmond, A., Lacaya, L. B., Bain, C., Calle, E. E., Aristizabal, N., Gatei, D., Ngelangel, C. A., Bull, D., Fentiman, I. S., Leske, M. C., Hannaford, P., Pike, M. C., Viladiu, P., Wang, D. Y., Peto, J., White, E., Weinstein, A. L., Theetranont, C., Fraser, G., La Vecchia, C., Martinez, L., Evstifeeva, T., Holck, S., Jin, F., Shearman, R., Nasca, P. C., Wang, Q. S., Stanford, J. L., Chilvers, C. E.D., Tulinius, H., Bishop, T., Coldman, A. J., Salazar, S. B., Gallagher, R. P., Peto, R., Reeves, G., Hiatt, R. A., Kunde, D., Boyle, P., Kenya, P., Molina, R., Salas, O., Negri, E., Liff, J. M., Primic-Zakelj, M., Lee, N., Doll, R., Anderson, K., Schairer, C., Band, P., Goodill, A., Goldbohm, R. A., Katsouyanni, K., Hu, J., Mao, Y., Noonan, E. A., Hislop, T. G., Meirik, O., Cuadros, A., Clavel, F., Ursin, G., Boosiri, B., Lansac, J., Schofield, F., Renaud, R., Kosmelj, K., Kolonel, L. M., Hulka, B., Berry, G., Daling, J. R., Jones, L., Mati, J. G., Hulka, B. S., McCredie, M., Spears, G. F.S., Trichopoulou, A., Schuman, L., Farley, T. M.M., Ravnihar, B., Wei, H. Y., Key, T., Skegg, D. C.G., Lewis, C., Bernstein, L., Miller, A. B., Hanson, R. L., Ross, R. K., Martin, N., Rohan, T., Collins, R., Yuan, J. M., Colditz, G., Gao, Y. T., MacLennan, R., Segala, C., Weiss, N. S., Cooper Booth, J., Andrieu, N., Banks, E., Richardson, S., van Leeuwen, F. E., Newcomb, P., Gammon, M. D., Wongsrichanalai, C., Friedman, G. D., Szklo, M., Baens, J., van den Brandt, P. A., Alexander, F. E., Wilson, H. G., Spirtas, R., Tajima, K., Gerber, M., Franceschi, S., Stare, J., Ron, E., Jelihovsky, T., Mabuchi, K., Piana, L., Wall, C., Schoenberg, J. A., Koetsawang, S., Apelo, R. A., Marchbanks, P., Stewart, W., Van Leeuven, M., Jimakorn, P., Beeson, W. L., Pardthaisong, T., Tryggvadottir, L., Zheng, W., Adami, H. O., Coates, R. J., Palet, A., Wingo, P. A., Thomas, D. B., Thomas, D., Enger, S., Trichopoulos, D., Chutivongse, S., Bulbrook, R. D., Rosero-Bixby, L., Gajalakshmi, V., de la Cruz, J. R., Hopper, J. L., Muller, A., Zhiheng, C., Beral, V., Hamajima, N., Ewertz, M., Varma, A. O., Nomura, A. M.Y., Rookus, M. A., Lee, H. P., Ebeling, K., Cuzick, J., Yang, P., Cuevas, H. R., Peterson, H. B., Izquierdo, A., Brinton, L. A., Nishan, P., Clarke, E. A., Hayward, J. L., Crossley, B., Yun, T., Kalache, A., Moller, T. R., Hutchinson, W. B., Green, J., Marubini, E., Hoover, R., Wax, Y., Modan, B., Ory, H. W., Duffy, S. W., Ranstam, J., Olsson, H., Lund, E., Gairard, B., Ferraroni, M., Paganini-Hill, A., Appleby, P., Shu, X. O., Vessey, M., Haile, R. W., Dabancens, A., Folsom, A. R., Langston, N., Talamini, R., Skegg, D., Neil, A., Chang-Claude, J., Bachelot, A., McMichael, A. J., Javier, B., Persson, I., Paul, C., Mahoney, M. C., Hirose, K., Rachawat, D., De Sanjosé, S., Longnecker, M. P., Johnson, K. C., Morabia, A., Preston, D., Levi, F., Silpisornkosol, S., Stalsberg, H., McPherson, K., Yeates, D., Lê, M. G., Chantarakul, N., Clavel-Chapelon, F., Secretariat, Cancer Research UK Epidemiology Unit, Beral V, Hamajima N, Hirose K, Rohan T, Calle EE, Heath CW, Coates RJ, Liff JM, Talamini R, Chantarakul N, Koetsawang S, Rachawat D, Morabia A, Schuman L, Stewart W, Szklo M, Bain C, Schofield F, Siskind V, Band P, Coldman AJ, Gallagher RP, Hislop TG, Yang P, Kolonel LM, Nomura AMY, Hu J, Johnson KC, Mao Y, De Sanjose S, Lee N, Marchbanks P, Ory HW, Peterson HB, Wilson HG, Wingo PA, Ebeling K, Kunde D, Nishan P, Hopper JL, Colditz G, Gajalakshmi V, Martin N, Pardthaisong T, Solpisornkosol S, Theetranont C, Boosiri B, Chutivongse S, Jimakorn P, Virutamasen P, Wongsrichanalai C, Ewertz M, Adami HO, Bergkvist L, Magnusson C, Persson I, Chang-Claude J, Paul C, Skegg DCG, Spears GFS, Boyle P, Evstifeeva T, Daling JR, Hutchinson WB, Malone K, Noonan EA, Stanford JL, Thomas DB, Weiss NS, White E, Andrieu N, Bremond A, Clavel F, Gairard B, Lansac J, Piana L, Renaud R, Izquierdo A, Viladiu P, Cuevas HR, Ontiveros P, Palet A, Salazar SB, Arsitizabal N, Cuadros A, Tryggvadottir L, Tulinius H, Bachelot A, Le MG, Peto J, Franceschi S, Lubin F, Modan B, Ron E, Wax Y, Friedman GD, Hiatt RA, Levi F, Bishop T, Kosmelj K, Primic-Zakelj M, Ravnihar B, Stare J, Beeson WL, Fraser G, Bulbrook RD, Cuzick J, Duffy SW, Fentiman IS, Hayward JL, Wang DY, McMichael AJ, McPherson K, Hanson RL, Leske MC, Mahoney MC, Nasca PC, Varma AO, Weinstein AL, Moller TR, Olsson H, Ranstam J, Goldbohm RA, van den Brandt PA, Apelo RA, Baens J, de la Cruz JR, Javier B, Lacaya LB, Ngelangel CA, La Vecchia C, Negri E, Marubini E, Ferraroni M, Gerber M, Richardson S, Segala C, Gatei D, Kenya P, Kungu A, Mati JG, Brinton LA, Hoover R, Schairer C, Spirtas R, Lee HP, Rookus MA, van Leeuwen FE, Schoenberg JA, McCredie M, Gammon MD, Clarke EA, Jones L, Neil A, Vessey M, Yeates D, Appleby P, Banks E, Bull D, Crossley B, Goodill A, Green J, Hermon C, Key T, Langston N, Lewis C, Reeves G, Collins R, Doll R, Peto R, Mabuchi K, Preston D, Hannaford P, Kay C, Rosero-Bixby L, Gao YT, Jin F, Yuan JM, Wei HY, Yun T, Zhiheng C, Berry G, Cooper Booth J, Jelihovsky T, MacLennan R, Shearman R, Wang QS, Baines CJ, Miller AB, Wall C, Lund E, Stalsberg H, Shu XO, Zheng W, Katsouyanni K, Trichopoulou A, Trichopoulos D, Dabancens A, Martinez L, Molina R, Salas O, Alexander XE, Anderson K, Folsom AR, Hulka BS, Bernstein L, Enger S, Haile RW, Paganini-Hill A, Pike MC, Ross RK, Ursin G, Yu MC, Longnecker MP, Newcomb P, Kalache A, Farley TMM, Holck S, Meirik O, and Universitat de Barcelona

Subjects
Cancer Research, medicine.medical_specialty, Epidemiology, Dones, Alcohol, tobacco, smoking, Càncer de mama, chemistry.chemical_compound, Breast cancer, Hàbit de fumar, breast cancer, Tabac, Tobacco, [SDV.SPEE] Life Sciences [q-bio]/Public Health and Epidemiology, medicine, Women, Gynecology, collaborative reanalysis, Obstetrics, business.industry, alcohol, Confounding, Smoking, medicine.disease, Tobbacco habit, Oncology, chemistry, Drinking of alcoholic beverages, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Meta-analysis, Relative risk, Consum d'alcohol, Risk assessment, business, Developed country
Abstract

COLLABORATORS (in alphabetical order of institution, study name, or location) Aichi Cancer Research Institute, Nagoya, Japan: N Hamajima, K Hirose, K Tajima; Albert Einstein College of Medicine, NY, USA: T Rohan; American Cancer Society, GA, USA: EE Calle, CW Jr Heath; Atlanta, Emory University, GA, USA: RJ Coates, JM Liff; Aviano Cancer Center, Pordenone, Italy: R Talamini; Mahidol University, Bangkok, Thailand: N Chantarakul, S Koetsawang, D Rachawat; Breast Tumor Collaborative Study, Johns Hopkins University, MD, USA: A Morabia, L Schuman, W Stewart, M Szklo; University of Queensland, Brisbane, Australia: C Bain, F Schofield, V Siskind; British Columbia Cancer Agency, BC, Canada: P Band, AJ Coldman, RP Gallagher, TG Hislop, P Yang; Cancer Research Center, University of Hawaii, Hawaii, USA: LM Kolonel, AMY Nomura; Canadian Cancer Registries Epidemiology Research Group, Canada: J Hu, KC Johnson, Y Mao; Catalán Institut of Oncology, Barcelona, Spain: S De Sanjosé; Centers for Disease Control & Prevention, GA, USA: N Lee, P Marchbanks, HW Ory, HB Peterson, HG Wilson, PA Wingo; Central Institute of Cancer Research, Berlin, Germany: K Ebeling, D Kunde, P Nishan; Centre for Genetic Epidemiology, University of Melbourne, Melbourne, Australia: JL Hopper; Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, MA, USA: G Colditz for Nurses' Health Study Research Group; Chennai Cancer Institute, Madras, India: V Gajalakshmi; Chiang Mai University, Chiang Mai, Thailand: N Martin, T Pardthaisong, S Silpisornkosol, C Theetranont; Chulalongkorn University, Bangkok, Thailand: B Boosiri, S Chutivongse, P Jimakorn, P Virutamasen, C Wongsrichanalai; Danish Cancer Society, Aalborg, Denmark: M Ewertz; Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden: HO Adami, L Bergkvist, C Magnusson, I Persson; Deutsches Krebsforschungszentrum, Heidelberg, Germany: J Chang-Claude; University of Otago, Dunedin, New Zealand: C Paul, DCG Skegg, GFS Spears; European Institute of Oncology, Milan, Italy: P Boyle, T Evstifeeva; Fred Hutchinson Cancer Research Center, WA, USA: JR Daling, WB Hutchinson, K Malone, EA Noonan, JL Stanford, DB Thomas, NS Weiss, E White; French Multicentre Breast Study, INSERM, Villejuif, France: N Andrieu, A Brêmond, F Clavel, B Gairard, J Lansac, L Piana, R Renaud; Girona Cancer Registry, Girona, Spain: A Izquierdo, P Viladiu; Hospital General de Mexico, Mexico City, Mexico: HR Cuevas, P Ontiveros, A Palet, SB Salazar; Hospital Universitario, Cali, Colombia: N Aristizabal, A Cuadros; Icelandic Cancer Society, Reykjavik, Iceland: L Tryggvadottir, H Tulinius; INSERM, Institut Gustave-Roussey, Villejuif, France: A Bachelot, MG Lê; Institute of Cancer Research, Sutton and London School of Hygiene and Tropical Medicine, UK: J Peto; International Agency for Research in Cancer, Lyon, France: S Franceschi; Israel Chaim Sheba Medical Centre, Tel-Hashomer, Israel: F Lubin, B Modan, E Ron, Y Wax; Kaiser Permanente, CA, USA: GD Friedman, RA Hiatt; Institut universitaire de medecine sociale et preventive, Lausanne, Switzerland: F Levi; Cancer Research UK Genetic Epidemiology Laboratory, Leeds, UK: T Bishop; Institute of Oncology, Ljubljana, Slovenia: K Kosmelj, M Primic-Zakelj, B Ravnihar, J Stare; Loma Linda University, CA, USA: WL Beeson, G Fraser; Cancer Research UK Department of Mathematics, Statistics & Epidemiology, London: RD Bulbrook, J Cuzick, SW Duffy, IS Fentiman, JL Hayward, DY Wang; London School of Hygiene & Tropical Medicine, London, UK: AJ McMichael, K McPherson; Long Island Breast Cancer Study, NY, USA: RL Hanson, MC Leske, MC Mahoney, PC Nasca, AO Varma, AL Weinstein; University Hospital, Lund, Sweden: TR Moller, H Olsson, J Ranstam; Maastricht University, Maastricht, The Netherlands: RA Goldbohm, PA van den Brandt; University of Philippines, Manila, Philippines: RA Apelo, J Baens, JR de la Cruz, B Javier, LB Lacaya, CA Ngelangel; Istituto ‘Mario Negri', Milan, Italy: C La Vecchia, E Negri; Istituto Nazionale Tumori, Divisione di Statistica Medica e Biometria, Milan, Italy: E Marubini; Istituto di Statistica Medica e Biometria, Milan, Italy: M Ferraroni; Montpellier Cancer Centre & INSERM, Montpellier, France: M Gerber, S Richardson, C Segala; Nairobi Centre for Research in Reproduction, Nairobi, Kenya: D Gatei, P Kenya, A Kungu, JG Mati; National Cancer Institute, MD, USA: LA Brinton, R Hoover, C Schairer; National Institute of Child Health & Human Development, MD, USA: R Spirtas; National University of Singapore, Singapore: HP Lee; The Netherlands Cancer Institute, Amsterdam, The Netherlands: MA Rookus, FE van Leeuwen for the Netherlands Oral Contraceptives and Breast Cancer Study Group; New Jersey State Department of Health, NJ, USA: JA Schoenberg; New South Wales Cancer Council, Sydney, Australia: M McCredie; Columbia University School of Public Health, NY, USA: MD Gammon; Ontario Cancer Treatment & Research Foundation, Ontario, Canada: EA Clarke; Department of Public Health & Primary Care, Oxford, UK: L Jones, A Neil, M Vessey, D Yeates; Cancer Research UK Epidemiology Unit, Oxford, UK (Secretariat): P Appleby, E Banks, V Beral, D Bull, B Crossley, A Goodill, J Green, C Hermon, T Key, N Langston, C Lewis, G Reeves; Cancer Research UK/MRC/BHF Clinical Trial Service Unit & Epidemiological Studies Unit, Oxford, UK: R Collins, R Doll, R Peto; Radiation Effects Research Foundation, Hiroshima, Japan: K Mabuchi, D Preston; Royal College of General Practitioners Oral Contraception Study, London, UK: P Hannaford, C Kay; University of Costa Rica, San Jose, Costa Rica: L Rosero-Bixby; Shanghai Cancer Institute, Shanghai, China: YT Gao, F Jin, J-M Yuan; Shanghai Institute of Planned Parenthood Research, Shanghai, China: HY Wei, T Yun, C Zhiheng; Department of Public Health, Sydney, Australia: G Berry, J Cooper Booth, T Jelihovsky, R MacLennan, R Shearman; Tianjin Cancer Institute, Tianjin, China: Q-S Wang; Department of Public Health Sciences, Toronto, Canada: CJ Baines, AB Miller, C Wall; Tromso University, Tromso, Norway: E Lund, H Stalsberg; Vanderbilt University, TN, USA: XO Shu, W Zheng; University of Athens Medical School, Athens, Greece: K Katsouyanni, A Trichopoulou, D Trichopoulos; University of Chile, Santiago, Chile: A Dabancens, L Martinez, R Molina, O Salas; University of Edinburgh, Edinburgh, UK: FE Alexander; University of Minnesota School of Public Health, MN, USA: K Anderson, AR Folsom on behalf of the Iowa Women's Health Study; University of North Carolina at Chapel Hill, School of Public Health, NC, USA: BS Hulka; University of Nottingham, Nottingham, UK: CED Chilvers; University of Southern California, LA, USA: L Bernstein, S Enger, RW Haile, A Paganini-Hill, MC Pike, RK Ross, G Ursin, MC Yu; University of Wisconsin Comprehensive Cancer Center, WI, USA: MP Longnecker, P Newcomb for the 4 State Study; Vasteras, Sweden: L Bergkvist; World Health Organisation, Geneva, Switzerland: A Kalache; World Health Organisation, UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction, Geneva, Switzerland: TMM Farley, S Holck, O Meirik. Analysis and writing committee: Beral V, Bull D, Doll R, Peto R, Reeves G Steering committee: Skegg D (Chairman), Colditz G, Hulka B, La Vecchia C, Magnusson C, Muller A, Peterson B, Pike M, Thomas D, Van Leeuven M.; International audience; Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58,515 women with invasive breast cancer and 95,067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19-1.45, P/=45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P

Published
2002

49. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

Author

Beral, V, Bull, D, Pirie, K, Reeves, G, Peto, R, Skegg, D, LaVecchia, C, Magnusson, C, Pike, MC, Thomas, D, Hamajima, N, Hirose, K, Tajima, K, Rohan, T, Friedenreich, CM, Calle, EE, Gapstur, SM, Patel, AV, Coates, RJ, Liff, JM, Talamini, R, Chantarakul, N, Koetsawang, S, Rachawat, D, Marcou, Y, Kakouri, E, Duffy, SW, Morabia, A, Schuman, L, Stewart, W, Szklo, M, Coogan, PF, Palmer, JR, Rosenberg, L, Band, P, Coldman, AJ, Gallagher, RP, Hislop, TG, Yang, P, Cummings, SR, Canfell, K, Sitas, F, Chao, P, Lissowska, J, Horn-Ross, PL, John, EM, Kolonel, LM, Nomura, AMY, Ghiasvand, R, Hu, J, Johnson, KC, Mao, Y, Callaghan, K, Crossley, B, Goodill, A, Green, J, Hermon, C, Key, T, Lindgard, I, Liu, B, Collins, R, Doll, R, Bishop, T, Fentiman, IS, De Sanjose, S, Gonzaler, CA, Lee, N, Marchbanks, P, Ory, HW, Peterson, HB, Wingo, P, Ebeling, K, Kunde, D, Nishan, P, Hopper, JL, Eliassen, H, Gajalakshmi, V, Martin, N, Pardthaisong, T, Silpisornkosol, S, Theetranont, C, Boosiri, B, Chutivongse, S, Jimakorn, P, Virutamasen, P, Wongsrichanalai, C, Neugut, A, Santella, R, Baines, CJ, Kreiger, N, Miller, AB, Wall, C, Tjonneland, A, Jorgensen, T, Stahlberg, C, Pedersen, AT, Flesch-Janys, D, Hakansson, N, Cauley, J, Heuch, I, Adami, HO, Persson, I, Weiderpass, E, Chang-Claude, J, Kaaks, R, McCredie, M, Paul, C, Skegg, DCG, Spears, GFS, Iwasaki, M, Tsugane, S, Anderson, G, Daling, JR, Hampton, J, Hutchinson, WB, Li, CI, Malone, K, Mandelson, M, Newcomb, P, Noonan, EA, Ray, RM, Stanford, JL, Tang, MTC, Thomas, DB, Weiss, NS, White, E, Izquierdo, A, Viladiu, P, Fourkala, EO, Jacobs, I, Menon, U, Ryan, A, Cuevas, HR, Ontiveros, P, Palet, A, Salazar, SB, Aristizabal, N, Cuadros, A, Tryggvadottir, L, Tulinius, H, Riboli, E, Andrieu, N, Bachelot, A, Le, MG, Bremond, A, Gairard, B, Lansac, J, Piana, L, Renaud, R, Clavel-Chapelon, F, Fournier, A, Touillaud, M, Mesrine, S, Chabbert-Buffet, N, Boutron-Ruault, MC, Wolk, A, Torres-Mejia, G, Franceschi, S, Romieu, I, Boyle, P, Lubin, F, Modan, B, Ron, E, Wax, Y, Friedman, GD, Hiatt, RA, Levi, F, Kosmelj, K, Primic-Zakelj, M, Ravnihar, B, Stare, J, Ekbom, A, Erlandsson, G, Beeson, WL, Fraser, G, Peto, J, Hanson, RL, Leske, MC, Mahoney, MC, Nasca, PC, Varma, AO, Weinstein, AL, Hartman, ML, Olsson, H, Goldbohm, RA, van den Brandt, PA, Palli, D, Teitelbaum, S, Apelo, RA, Baens, J, de la Cruz, JR, Javier, B, Lacaya, LB, Ngelangel, CA, La Vecchia, C, Negri, E, Marubini, E, Ferraroni, M, Gerber, M, Richardson, S, Segala, C, Gatei, D, Kenya, P, Kungu, A, Mati, JG, Brinton, LA, Freedman, M, Hoover, R, Schairer, C, Ziegler, R, Banks, E, Spirtas, R, Lee, HP, Rookus, MA, van Leeuwen, FE, Schoenberg, JA, Graff-Iversen, S, Selmer, R, Jones, L, McPherson, K, Neil, A, Vessey, M, Yeates, D, Mabuchi, K, Preston, D, Hannaford, P, Kay, C, McCann, SE, Rosero-Bixby, L, Gao, YT, Jin, F, Yuan, J-M, Wei, HY, Yun, T, Zhiheng, C, Berry, G, Booth, JC, Jelihovsky, T, MacLennan, R, Shearman, R, Hadjisavvas, A, Kyriacou, K, Loisidou, M, Zhou, X, Wang, Q-S, Kawai, M, Minami, Y, Tsuji, I, Lund, E, Kumle, M, Stalsberg, H, Shu, XO, Zheng, W, Monninkhof, EM, Onland-Moret, NC, Peeters, PHM, Katsouyanni, K, Trichopoulou, A, Trichopoulos, D, Tzonou, A, Baltzell, KA, Dabancens, A, Martinez, L, Molina, R, Salas, O, Alexander, FE, Anderson, K, Folsom, AR, Gammon, MD, Hulka, BS, Millikan, R, Chilvers, CED, Lumachi, F, Bain, C, Schofield, F, Siskind, V, Rebbeck, TR, Bernstein, LR, Enger, S, Haile, RW, Paganini-Hill, A, Ross, RK, Ursin, G, Wu, AH, Yu, MC, Ewertz, DM, Clarke, EA, Bergkvist, L, Anderson, GL, Gass, M, O'Sullivan, MJ, Kalache, A, Farley, TMM, Holck, S, Meirik, O, Fukao, A, Factors, CGH, Grp, SHNHSIIIR, Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, RS: GROW - School for Oncology and Reproduction, RS: GROW - R1 - Prevention, RS: CAPHRI - R5 - Optimising Patient Care, and Collaborative Group on Hormonal Factors in Breast Cancer

Subjects
Aging, Breast cancer, Risk factors, Menopause, Menarche, cancer, malignancy, Ethnic origin, Disease, 0302 clinical medicine, Breast cancer, Risk Factors, Neoplasms, Receptors, Epidemiology, 80 and over, 030212 general & internal medicine, skin and connective tissue diseases, Aged, 80 and over, Patient, Obstetrics, Reproduction, Smoking, Age Factors, Middle Aged, Reproducibility, 3. Good health, Menopause, Receptors, Estrogen, Oncology, 030220 oncology & carcinogenesis, Menarche, Hormonal therapy, Female, epidemiology, Cancer Type - Breast Cancer, history, Adult, Risk, trends, medicine.medical_specialty, Design, Neoplasms, Hormone-Dependent, Requiring prolonged observation, Hormone Replacement Therapy, Oncology and Carcinogenesis, Breast Neoplasms, and over, Validity, methods, 03 medical and health sciences, Age, Clinical Research, Breast Cancer, medicine, Humans, cancer, Neoplasm Invasiveness, Women, Oncology & Carcinogenesis, Hormone-Dependent, breast, Aged, Gynecology, Collaborative Group on Hormonal Factors in Breast Cancer, therapy, business.industry, Contraception/Reproduction, Research, Estrogens, Etiology - Resources and Infrastructure, medicine.disease, Estrogen, Good Health and Well Being, cessation, Premenopause, Risk factors, Relative risk, Recall, business, malignancy, Meta-Analysis
Abstract

Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women.Methods Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression.Findings Breast cancer risk increased by a factor of 1.050 (95% CI 1.044-1.057; p < 0.0001) for every year younger at menarche, and independently by a smaller amount (1.029, 1.025-1.032; p < 0.0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45-54 years 1.43, 1.33-1.52, p < 0.001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women's year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p < 0.006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p < 0.01 for both comparisons).Interpretation The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women's total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptor-positive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours.Funding Cancer Research UK.

Published
2012

50. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

Author

Beral, V. Bull, D. Pirie, K. Reeves, G. Peto, R. and Skegg, D. LaVecchia, C. Magnusson, C. Pike, M. C. and Thomas, D. Hamajima, N. Hirose, K. Tajima, K. Rohan, T. and Friedenreich, C. M. Calle, E. E. Gapstur, S. M. Patel, A. V. Coates, R. J. Liff, J. M. Talamini, R. and Chantarakul, N. Koetsawang, S. Rachawat, D. Marcou, Y. and Kakouri, E. Duffy, S. W. Morabia, A. Schuman, L. and Stewart, W. Szklo, M. Coogan, P. F. Palmer, J. R. and Rosenberg, L. Band, P. Coldman, A. J. Gallagher, R. P. and Hislop, T. G. Yang, P. Cummings, S. R. Canfell, K. and Sitas, F. Chao, P. Lissowska, J. Horn-Ross, P. L. John, E. M. Kolonel, L. M. Nomura, A. M. Y. Ghiasvand, R. Hu, J. Johnson, K. C. Mao, Y. Callaghan, K. Crossley, B. and Goodill, A. Green, J. Hermon, C. Key, T. Lindgard, I. and Liu, B. Collins, R. Doll, R. Bishop, T. Fentiman, I. S. De Sanjose, S. Gonzaler, C. A. Lee, N. Marchbanks, P. and Ory, H. W. Peterson, H. B. Wingo, P. Ebeling, K. and Kunde, D. Nishan, P. Hopper, J. L. Eliassen, H. and Gajalakshmi, V. Martin, N. Pardthaisong, T. Silpisornkosol, S. Theetranont, C. Boosiri, B. Chutivongse, S. Jimakorn, P. Virutamasen, P. Wongsrichanalai, C. Neugut, A. and Santella, R. Baines, C. J. Kreiger, N. Miller, A. B. and Wall, C. Tjonneland, A. Jorgensen, T. Stahlberg, C. and Pedersen, A. Tonnes Flesch-Janys, D. Hakansson, N. Cauley, J. Heuch, I. Adami, H. O. Persson, I. Weiderpass, E. and Chang-Claude, J. Kaaks, R. McCredie, M. Paul, C. Spears, G. F. S. Iwasaki, M. Tsugane, S. Anderson, G. Daling, J. R. Hampton, J. Hutchinson, W. B. Li, C. I. Malone, K. and Mandelson, M. Newcomb, P. Noonan, E. A. Ray, R. M. and Stanford, J. L. Tang, M. T. C. Weiss, N. S. White, E. and Izquierdo, A. Viladiu, P. Fourkala, E. O. Jacobs, I. and Menon, U. Ryan, A. Cuevas, H. R. Ontiveros, P. Palet, A. and Salazar, S. B. Aristizabal, N. Cuadros, A. and Tryggvadottir, L. Tulinius, H. Riboli, E. Andrieu, N. and Bachelot, A. Le, M. G. Bremond, A. Gairard, B. Lansac, J. Piana, L. Renaud, R. Clavel-Chapelon, F. Fournier, A. and Touillaud, M. Mesrine, S. Chabbert-Buffet, N. and Boutron-Ruault, M. C. Wolk, A. Torres-Mejia, G. Franceschi, S. Romieu, I. Boyle, P. Lubin, F. Modan, B. Ron, E. and Wax, Y. Friedman, G. D. Hiatt, R. A. Levi, F. and Kosmelj, K. Primic-Zakelj, M. Ravnihar, B. Stare, J. and Ekbom, A. Erlandsson, G. Beeson, W. L. Fraser, G. Peto, J. Hanson, R. L. Leske, M. C. Mahoney, M. C. Nasca, P. C. Varma, A. O. Weinstein, A. L. Hartman, M. L. Olsson, H. Goldbohm, R. A. van den Brandt, P. A. Palli, D. and Teitelbaum, S. Apelo, R. A. Baens, J. de la Cruz, J. R. and Javier, B. Lacaya, L. B. Ngelangel, C. A. La Vecchia, C. and Negri, E. Marubini, E. Ferraroni, M. Gerber, M. and Richardson, S. Segala, C. Gatei, D. Kenya, P. Kungu, A. and Mati, J. G. Brinton, L. A. Freedman, M. Hoover, R. and Schairer, C. Ziegler, R. Banks, E. Spirtas, R. Lee, H. P. Rookus, M. A. van Leeuwen, F. E. Schoenberg, J. A. and Graff-Iversen, S. Selmer, R. Jones, L. McPherson, K. and Neil, A. Vessey, M. Yeates, D. Mabuchi, K. Preston, D. and Hannaford, P. Kay, C. McCann, S. E. Rosero-Bixby, L. and Gao, Y. T. Jin, F. Yuan, J-M Wei, H. Y. Yun, T. and Zhiheng, C. Berry, G. Booth, J. Cooper Jelihovsky, T. and MacLennan, R. Shearman, R. Hadjisavvas, A. Kyriacou, K. and Loisidou, M. Zhou, X. Wang, Q-S Kawai, M. Minami, Y. and Tsuji, I. Lund, E. Kumle, M. Stalsberg, H. Shu, X. O. and Zheng, W. Monninkhof, E. M. Onland-Moret, N. C. Peeters, P. H. M. Katsouyanni, K. Trichopoulou, A. Trichopoulos, D. and Tzonou, A. Baltzell, K. A. Dabancens, A. Martinez, L. and Molina, R. Salas, O. Alexander, F. E. Anderson, K. and Folsom, A. R. Gammon, M. D. Hulka, B. S. Millikan, R. and Chilvers, C. E. D. Lumachi, F. Bain, C. Schofield, F. and Siskind, V. Rebbeck, T. R. Bernstein, L. R. Enger, S. and Haile, R. W. Paganini-Hill, A. Ross, R. K. Ursin, G. Wu, A. H. Yu, M. C. Ewertz, Denmark M. Clarke, E. A. and Bergkvist, L. Gass, M. O'Sullivan, M. J. Kalache, A. and Farley, T. M. M. Holck, S. Meirik, O. Fukao, A. and Collaborative Grp Hormonal Factors Collaborative Grp Hormonal Factors S Hankinson Nurses Hlth Study I II

Subjects
skin and connective tissue diseases
Abstract

Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women. Methods Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression. Findings Breast cancer risk increased by a factor of 1.050 (95% CI 1.044-1.057; p < 0.0001) for every year younger at menarche, and independently by a smaller amount (1.029, 1.025-1.032; p < 0.0001), for every year older at menopause. Premenopausal women had a greater risk of breast cancer than postmenopausal women of an identical age (RR at age 45-54 years 1.43, 1.33-1.52, p < 0.001). All three of these associations were attenuated by increasing adiposity among postmenopausal women, but did not vary materially by women’s year of birth, ethnic origin, childbearing history, smoking, alcohol consumption, or hormonal contraceptive use. All three associations were stronger for lobular than for ductal tumours (p < 0.006 for each comparison). The effect of menopause in women of an identical age and trends by age at menopause were stronger for oestrogen receptor-positive disease than for oestrogen receptor-negative disease (p < 0.01 for both comparisons). Interpretation The effects of menarche and menopause on breast cancer risk might not be acting merely by lengthening women’s total number of reproductive years. Endogenous ovarian hormones are more relevant for oestrogen receptor-positive disease than for oestrogen receptor-negative disease and for lobular than for ductal tumours. Funding Cancer Research UK.

Published
2012

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