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Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
Authors :
Couch, FJ Kuchenbaecker, KB Michailidou, K Mendoza-Fandino, GA Nord, S Lilyquist, J Olswold, C Hallberg, E Agata, S Ahsan, H Aittomaeki, K Ambrosone, C Andrulis, IL Anton-Culver, H Arndt, V Arun, BK Arver, B Barile, M Barkardottir, RB Barrowdale, D Beckmann, L Beckmann, MW Benitez, J Blank, SV Blomqvist, C Bogdanova, NV Bojesen, SE Bolla, MK Bonanni, B Brauch, H Brenner, H Burwinkel, B Buys, SS Caldes, T Caligo, MA Canzian, F Carpenter, J Chang-Claude, J Chanock, SJ Chung, WK Claes, KBM Cox, A Cross, SS Cunningham, JM Czene, K Daly, MB Damiola, F Darabi, H de la Hoya, M Devilee, P Diez, O Ding, YC Dolcetti, R Domchek, SM Dorfling, CM dos-Santos-Silva, I Dumont, M Dunning, AM Eccles, DM Ehrencrona, H Ekici, AB Eliassen, H Ellis, S Fasching, PA Figueroa, J Flesch-Janys, D Foersti, A Fostira, F Foulkes, WD Friebel, T Friedman, E Frost, D Gabrielson, M Gammon, MD Ganz, PA Gapstur, SM Garber, J Gaudet, MM Gayther, SA Gerdes, A-M Ghoussaini, M Giles, GG Glendon, G Godwin, AK Goldberg, MS Goldgar, DE Gonzalez-Neira, A Greene, MH Gronwald, J Guenel, P Gunter, M Haeberle, L Haiman, CA Hamann, U Hansen, TVO Hart, S Healey, S Heikkinen, T Henderson, BE Herzog, J Hogervorst, FBL Hollestelle, A Hooning, MJ Hoover, RN Hopper, JL Humphreys, K Hunter, DJ Huzarski, T Imyanitov, EN Isaacs, C Jakubowska, A James, P Janavicius, R Jensen, UB John, EM Jones, M Kabisch, M Kar, S Karlan, BY Khan, S Khaw, K-T Kibriya, MG Knight, JA Ko, Y-D Konstantopoulou, I Kosma, V-M Kristensen, V Kwong, A Laitman, Y Lambrechts, D Lazaro, C Lee, E Le Marchand, L Lester, J Lindblom, A Lindor, N Lindstrom, S Liu, J Long, J Lubinski, J Mai, PL Makalic, E Malone, KE Mannermaa, A Manoukian, S Margolin, S Marme, F Martens, JWM McGuffog, L Meindl, A Miller, A Milne, RL Miron, P Montagna, M Mazoyer, S Mulligan, AM Muranen, TA Nathanson, KL Neuhausen, SL Nevanlinna, H Nordestgaard, BG Nussbaum, RL Offit, K Olah, E Olopade, OI Olson, JE Osorio, A Park, SK Peeters, PH Peissel, B Peterlongo, P Peto, J Phelan, CM Pilarski, R Poppe, B Pylkaes, K Radice, P Rahman, N Rantala, J Rappaport, C Rennert, G Richardson, A Robson, M Romieu, I Rudolph, A Rutgers, EJ Sanchez, M-J Santella, RM Sawyer, EJ Schmidt, DF Schmidt, MK Schmutzler, RK Schumacher, F Scott, R Senter, L Sharma, P Simard, J Singer, CF Sinilnikova, OM Soucy, P Southey, M Steinemann, D Stenmark-Askmalm, M Stoppa-Lyonnet, D Swerdlow, A Szabo, CI Tamimi, R Tapper, W Teixeira, MR Teo, S-H Terry, MB Thomassen, M Thompson, D Tihomirova, L Toland, AE Tollenaar, RAEM Tomlinson, I Truong, T Tsimiklis, H Teule, A Tumino, R Tung, N Turnbull, C Ursin, G van Deurzen, CHM van Rensburg, EJ Varon-Mateeva, R Wang, Z Wang-Gohrke, S Weiderpass, E Weitzel, JN Whittemore, A Wildiers, H Winqvist, R Yang, XR Yannoukakos, D Yao, S Zamora, MP Zheng, W Hall, P Kraft, P Vachon, C Slager, S Chenevix-Trench, G Pharoah, PDP Monteiro, AAN Garcia-Closas, M Easton, DF Antoniou, AC Couch, FJ Kuchenbaecker, KB Michailidou, K Mendoza-Fandino, GA Nord, S Lilyquist, J Olswold, C Hallberg, E Agata, S Ahsan, H Aittomaeki, K Ambrosone, C Andrulis, IL Anton-Culver, H Arndt, V Arun, BK Arver, B Barile, M Barkardottir, RB Barrowdale, D Beckmann, L Beckmann, MW Benitez, J Blank, SV Blomqvist, C Bogdanova, NV Bojesen, SE Bolla, MK Bonanni, B Brauch, H Brenner, H Burwinkel, B Buys, SS Caldes, T Caligo, MA Canzian, F Carpenter, J Chang-Claude, J Chanock, SJ Chung, WK Claes, KBM Cox, A Cross, SS Cunningham, JM Czene, K Daly, MB Damiola, F Darabi, H de la Hoya, M Devilee, P Diez, O Ding, YC Dolcetti, R Domchek, SM Dorfling, CM dos-Santos-Silva, I Dumont, M Dunning, AM Eccles, DM Ehrencrona, H Ekici, AB Eliassen, H Ellis, S Fasching, PA Figueroa, J Flesch-Janys, D Foersti, A Fostira, F Foulkes, WD Friebel, T Friedman, E Frost, D Gabrielson, M Gammon, MD Ganz, PA Gapstur, SM Garber, J Gaudet, MM Gayther, SA Gerdes, A-M Ghoussaini, M Giles, GG Glendon, G Godwin, AK Goldberg, MS Goldgar, DE Gonzalez-Neira, A Greene, MH Gronwald, J Guenel, P Gunter, M Haeberle, L Haiman, CA Hamann, U Hansen, TVO Hart, S Healey, S Heikkinen, T Henderson, BE Herzog, J Hogervorst, FBL Hollestelle, A Hooning, MJ Hoover, RN Hopper, JL Humphreys, K Hunter, DJ Huzarski, T Imyanitov, EN Isaacs, C Jakubowska, A James, P Janavicius, R Jensen, UB John, EM Jones, M Kabisch, M Kar, S Karlan, BY Khan, S Khaw, K-T Kibriya, MG Knight, JA Ko, Y-D Konstantopoulou, I Kosma, V-M Kristensen, V Kwong, A Laitman, Y Lambrechts, D Lazaro, C Lee, E Le Marchand, L Lester, J Lindblom, A Lindor, N Lindstrom, S Liu, J Long, J Lubinski, J Mai, PL Makalic, E Malone, KE Mannermaa, A Manoukian, S Margolin, S Marme, F Martens, JWM McGuffog, L Meindl, A Miller, A Milne, RL Miron, P Montagna, M Mazoyer, S Mulligan, AM Muranen, TA Nathanson, KL Neuhausen, SL Nevanlinna, H Nordestgaard, BG Nussbaum, RL Offit, K Olah, E Olopade, OI Olson, JE Osorio, A Park, SK Peeters, PH Peissel, B Peterlongo, P Peto, J Phelan, CM Pilarski, R Poppe, B Pylkaes, K Radice, P Rahman, N Rantala, J Rappaport, C Rennert, G Richardson, A Robson, M Romieu, I Rudolph, A Rutgers, EJ Sanchez, M-J Santella, RM Sawyer, EJ Schmidt, DF Schmidt, MK Schmutzler, RK Schumacher, F Scott, R Senter, L Sharma, P Simard, J Singer, CF Sinilnikova, OM Soucy, P Southey, M Steinemann, D Stenmark-Askmalm, M Stoppa-Lyonnet, D Swerdlow, A Szabo, CI Tamimi, R Tapper, W Teixeira, MR Teo, S-H Terry, MB Thomassen, M Thompson, D Tihomirova, L Toland, AE Tollenaar, RAEM Tomlinson, I Truong, T Tsimiklis, H Teule, A Tumino, R Tung, N Turnbull, C Ursin, G van Deurzen, CHM van Rensburg, EJ Varon-Mateeva, R Wang, Z Wang-Gohrke, S Weiderpass, E Weitzel, JN Whittemore, A Wildiers, H Winqvist, R Yang, XR Yannoukakos, D Yao, S Zamora, MP Zheng, W Hall, P Kraft, P Vachon, C Slager, S Chenevix-Trench, G Pharoah, PDP Monteiro, AAN Garcia-Closas, M Easton, DF Antoniou, AC
Publication Year :
2016
Abstract
Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction.
Details
Database :
OAIster
Publication Type :
Electronic Resource
Accession number :
edsoai.on1315714469
Document Type :
Electronic Resource