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1. Real-life evaluation of molecular multiplex IgE test methods in the diagnosis of pollen associated food allergy

Author

European Commission, Rohrhofer, Johanna [0000-0002-2783-2099], Koidl, Larissa [0000-0001-9974-7929], Asero, Ricardo [0000-0002-8277-1700], Brockow, Knut [0000-0002-2775-3681], Díaz-Perales, Araceli [0000-0002-1093-3627], Faber, Margaretha [0000-0002-1277-5052], Gebhardt, Julia [0000-0002-5529-7337], Torres, María José [0000-0001-5228-471X], Jensen-Jarolim, Erika [0000-0003-4019-5765], Zehetmayer, Sonja [0000-0001-6863-7997], Untersmayr, Eva [0000-0002-1963-499X], Diem, Luisa, Neuherz, Bellinda, Rohrhofer, Johanna, Koidl, Larissa, Asero, Ricardo, Brockow, Knut, Díaz-Perales, Araceli, Faber, Margaretha, Gebhardt, Julia, Torres, María José, Jensen-Jarolim, Erika, Zehetmayer, Sonja, Untersmayr, Eva, European Commission, Rohrhofer, Johanna [0000-0002-2783-2099], Koidl, Larissa [0000-0001-9974-7929], Asero, Ricardo [0000-0002-8277-1700], Brockow, Knut [0000-0002-2775-3681], Díaz-Perales, Araceli [0000-0002-1093-3627], Faber, Margaretha [0000-0002-1277-5052], Gebhardt, Julia [0000-0002-5529-7337], Torres, María José [0000-0001-5228-471X], Jensen-Jarolim, Erika [0000-0003-4019-5765], Zehetmayer, Sonja [0000-0001-6863-7997], Untersmayr, Eva [0000-0002-1963-499X], Diem, Luisa, Neuherz, Bellinda, Rohrhofer, Johanna, Koidl, Larissa, Asero, Ricardo, Brockow, Knut, Díaz-Perales, Araceli, Faber, Margaretha, Gebhardt, Julia, Torres, María José, Jensen-Jarolim, Erika, Zehetmayer, Sonja, and Untersmayr, Eva

Abstract

Diagnosis of food allergies is challenging, as combining information from specific IgE (sIgE)-sensitization pattern and skin prick tests (SPTs) with clinical history is necessary for a personalized management of allergic patients. The aim of this study was to compare two molecular tests, the ImmunoCAP ISAC (ISAC) and the Allergy Explorer, version 2 (ALEX2 ) in the context of pollen food syndrome (PFS) diagnosis in a real-life scenario, to assess the benefit of multiplex testing in PFS patients.

Published
2022

2. Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics and perspectives – a report of the European Academy of Allergy and Clinical Immunology (EAACI)

Author

European Academy of Allergy and Clinical Immunology, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Research Foundation - Flanders, Istituto Italiano di Tecnologia, Fondazione Telethon, Ministero della Salute, Comunidad de Madrid, German Research Foundation, European Commission, Sokolowska, Milena [0000-0001-9710-6685], Agache, Ioana [0000-0001-7994-364X], Akdis, Cezmi A. [0000-0001-8020-019X], Akdis, Mubeccel [0000-0003-0554-9943], Barcik, Weronika [0000-0001-8580-9690], Brough, Helen [0000-0001-7203-0813], Eiwegger, Thomas [0000-0002-2914-7829], Eliaszewicz, Andrzej [0000-0002-8980-1474], Feleszko, Wojciech [0000-0001-6613-2012], Gómez-Casado, C. [0000-0002-7707-6367], Hoffmann-Sommergruber, Karin [0000-0002-8830-058X], Janda, Jozef [0000-0001-9958-5683], Jiménez Saiz, Rodrigo [0000-0002-0606-3251], Knol, Edward [0000-0001-7368-9820], Krohn, Kortekaas [0000-0003-3649-1131], Kothari, Akash [0000-0003-1980-161X], Moniuszko, Marcin [0000-0001-7183-3120], Morita, Hideaki [0000-0003-0928-8322], Nadeau, Kari C. [0000-0002-2146-2955], Ozdemir, Cevdet [0000-0002-9284-4520], Pali-Schöll, Isabella [0000-0003-2089-6011], Palomares, O. [0000-0003-4516-0369], Papaleo, Francesco [0000-0002-6326-0657], Prunicki, Mary [0000-0002-5511-8896], Schmidt-Weber, C. B. [0000-0002-3203-8084], Schwarze, Jürgen [0000-0002-6899-748X], Tramper-Stranders, Gerdien [0000-0002-0228-5375], Veen, Willem van de [0000-0001-9951-6688], Untersmayr, Eva [0000-0002-1963-499X], Sokolowska, Milena, Lukasik, Z., Agache, Ioana, Akdis, Cezmi A., Akdis, D., Akdis, Mubeccel, Barcik, Weronika, Brough, Helen, Eiwegger, Thomas, Eliaszewicz, Andrzej, Eyerich, Stephanie, Feleszko, Wojciech, Gómez-Casado, C., Hoffmann-Sommergruber, Karin, Janda, Jozef, Jiménez Saiz, Rodrigo, Jutel, Marek, Knol, Edward, Krohn, Kortekaas, Kothari, Akash, Makowska, J., Moniuszko, Marcin, Morita, Hideaki, O’Mahony, L., Nadeau, Kari C., Ozdemir, Cevdet, Pali-Schöll, Isabella, Palomares, O., Papaleo, Francesco, Prunicki, Mary, Schmidt-Weber, C. B., Sediva, A., Schwarze, Jürgen, Shamji, M. H., Tramper-Stranders, Gerdien, Veen, Willem van de, Untersmayr, Eva, European Academy of Allergy and Clinical Immunology, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Research Foundation - Flanders, Istituto Italiano di Tecnologia, Fondazione Telethon, Ministero della Salute, Comunidad de Madrid, German Research Foundation, European Commission, Sokolowska, Milena [0000-0001-9710-6685], Agache, Ioana [0000-0001-7994-364X], Akdis, Cezmi A. [0000-0001-8020-019X], Akdis, Mubeccel [0000-0003-0554-9943], Barcik, Weronika [0000-0001-8580-9690], Brough, Helen [0000-0001-7203-0813], Eiwegger, Thomas [0000-0002-2914-7829], Eliaszewicz, Andrzej [0000-0002-8980-1474], Feleszko, Wojciech [0000-0001-6613-2012], Gómez-Casado, C. [0000-0002-7707-6367], Hoffmann-Sommergruber, Karin [0000-0002-8830-058X], Janda, Jozef [0000-0001-9958-5683], Jiménez Saiz, Rodrigo [0000-0002-0606-3251], Knol, Edward [0000-0001-7368-9820], Krohn, Kortekaas [0000-0003-3649-1131], Kothari, Akash [0000-0003-1980-161X], Moniuszko, Marcin [0000-0001-7183-3120], Morita, Hideaki [0000-0003-0928-8322], Nadeau, Kari C. [0000-0002-2146-2955], Ozdemir, Cevdet [0000-0002-9284-4520], Pali-Schöll, Isabella [0000-0003-2089-6011], Palomares, O. [0000-0003-4516-0369], Papaleo, Francesco [0000-0002-6326-0657], Prunicki, Mary [0000-0002-5511-8896], Schmidt-Weber, C. B. [0000-0002-3203-8084], Schwarze, Jürgen [0000-0002-6899-748X], Tramper-Stranders, Gerdien [0000-0002-0228-5375], Veen, Willem van de [0000-0001-9951-6688], Untersmayr, Eva [0000-0002-1963-499X], Sokolowska, Milena, Lukasik, Z., Agache, Ioana, Akdis, Cezmi A., Akdis, D., Akdis, Mubeccel, Barcik, Weronika, Brough, Helen, Eiwegger, Thomas, Eliaszewicz, Andrzej, Eyerich, Stephanie, Feleszko, Wojciech, Gómez-Casado, C., Hoffmann-Sommergruber, Karin, Janda, Jozef, Jiménez Saiz, Rodrigo, Jutel, Marek, Knol, Edward, Krohn, Kortekaas, Kothari, Akash, Makowska, J., Moniuszko, Marcin, Morita, Hideaki, O’Mahony, L., Nadeau, Kari C., Ozdemir, Cevdet, Pali-Schöll, Isabella, Palomares, O., Papaleo, Francesco, Prunicki, Mary, Schmidt-Weber, C. B., Sediva, A., Schwarze, Jürgen, Shamji, M. H., Tramper-Stranders, Gerdien, Veen, Willem van de, and Untersmayr, Eva

Abstract

With the worldwide spread of the novel Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) resulting in declaration of a pandemic by the World Health Organization (WHO) on March 11, 2020, the SARS‐CoV‐2‐induced Coronavirus disease‐19 (COVID‐19) has become one of the main challenges of our times. The high infection rate and the severe disease course led to major safety and social restriction measures worldwide. There is an urgent need of unbiased expert knowledge guiding the development of efficient treatment and prevention strategies. This report summarizes current immunological data on mechanisms associated with the SARS‐CoV‐2 infection and COVID‐19 development and progression to the most severe forms. We characterize the differences between adequate innate and adaptive immune response in mild disease and the deep immune dysfunction in the severe multi‐organ disease. The similarities of the human immune response to SARS‐CoV‐2 and the SARS‐CoV and MERS‐CoV are underlined. We also summarize known and potential SARS‐CoV‐2 receptors on epithelial barriers, immune cells, endothelium and clinically involved organs such as lung, gut, kidney, cardiovascular and neuronal system. Finally, we discuss the known and potential mechanisms underlying the involvement of comorbidities, gender and age in development of COVID‐19. Consequently, we highlight the knowledge gaps and urgent research requirements to provide a quick roadmap for ongoing and needed COVID‐19 studies.

Published
2020

3. Real-life evaluation of molecular multiplex IgE test methods in the diagnosis of pollen associated food allergy

Author

Luisa Diem, Bellinda Neuherz, Johanna Rohrhofer, Larissa Koidl, Riccardo Asero, Knut Brockow, Araceli Diaz Perales, Margaretha Faber, Julia Gebhardt, María José Torres, Erika Jensen‐Jarolim, Sonja Zehetmayer, Eva Untersmayr, European Commission, Rohrhofer, Johanna [0000-0002-2783-2099], Koidl, Larissa [0000-0001-9974-7929], Asero, Riccardo [0000-0002-8277-1700], Brockow, Knut [0000-0002-2775-3681], Diaz Perales, Araceli [0000-0002-1093-3627], Faber, Margaretha [0000-0002-1277-5052], Gebhardt, Julia [0000-0002-5529-7337], Torres, María José [0000-0001-5228-471X], Jensen-Jarolim, Erika [0000-0003-4019-5765], Zehetmayer, Sonja [0000-0001-6863-7997], Untersmayr, Eva [0000-0002-1963-499X], Rohrhofer, Johanna, Koidl, Larissa, Asero, Riccardo, Brockow, Knut, Diaz Perales, Araceli, Faber, Margaretha, Gebhardt, Julia, Torres, María José, Jensen-Jarolim, Erika, Zehetmayer, Sonja, and Untersmayr, Eva

Subjects
Immunology, Allergens, Immunoglobulin E, Profilins, Multiplex testing, Food allergy, Immunology and Allergy, Humans, Pollen, Molecular diagnosis, Pollen food syndrome, Food Hypersensitivity, Skin Tests
Abstract

13 Pág., Diagnosis of food allergies is challenging, as combining information from specific IgE (sIgE)-sensitization pattern and skin prick tests (SPTs) with clinical history is necessary for a personalized management of allergic patients. The aim of this study was to compare two molecular tests, the ImmunoCAP ISAC (ISAC) and the Allergy Explorer, version 2 (ALEX2 ) in the context of pollen food syndrome (PFS) diagnosis in a real-life scenario, to assess the benefit of multiplex testing in PFS patients., This work was financially supported by the H2020 EU project “AllerScreening” (H2020-NMBP-X-KET-2017-768641). EJJ was supported by the Danube Allergy Research Cluster, #08, Vienna and Krems, Austria

Published
2022

4. Immunology of COVID‐19: mechanisms, clinical outcome, diagnostics and perspectives – a report of the European Academy of Allergy and Clinical Immunology (EAACI)

Author

Wojciech Feleszko, Isabella Pali-Schöll, Weronika Barcik, Jozef Janda, Hideaki Morita, Rodrigo Jiménez-Saiz, Gerdien A. Tramper-Stranders, Willem van de Veen, Kari C. Nadeau, Marcin Moniuszko, Akash Kothari, Oscar Palomares, Cezmi A. Akdis, Cristina Gomez-Casado, Karin Hoffmann-Sommergruber, Stefanie Eyerich, Inge Kortekaas Krohn, Joanna Makowska, Mohamed H. Shamji, Carsten B. Schmidt-Weber, Anna Sediva, Helen A. Brough, Mary Prunicki, Zuzanna Lukasik, Eva Untersmayr, Francesco Papaleo, Milena Sokolowska, Mübeccel Akdis, Ioana Agache, Cevdet Ozdemir, Andrzej Eljaszewicz, Thomas Eiwegger, Edward F. Knol, Deniz Akdis, Marek Jutel, Jürgen Schwarze, Liam O'Mahony, European Academy of Allergy and Clinical Immunology, Swiss National Science Foundation, Ministerio de Economía y Competitividad (España), Research Foundation - Flanders, Istituto Italiano di Tecnologia, Fondazione Telethon, Ministero della Salute, Comunidad de Madrid, German Research Foundation, European Commission, Sokolowska, Milena, Agache, Ioana, Akdis, Cezmi A., Akdis, Mubeccel, Barcik, Weronika, Brough, Helen, Eiwegger, Thomas, Eliaszewicz, Andrzej, Feleszko, Wojciech, Gómez-Casado, C., Hoffmann-Sommergruber, Karin, Janda, Jozef, Jiménez Saiz, Rodrigo, Knol, Edward, Krohn, Kortekaas, Kothari, Akash, Moniuszko, Marcin, Morita, Hideaki, Nadeau, Kari C., Ozdemir, Cevdet, Pali-Schöll, Isabella, Palomares, O., Papaleo, Francesco, Prunicki, Mary, Schmidt-Weber, C. B., Schwarze, Jürgen, Tramper-Stranders, Gerdien, Veen, Willem van de, Untersmayr, Eva, Dermatology, Sokolowska, Milena [0000-0001-9710-6685], Agache, Ioana [0000-0001-7994-364X], Akdis, Cezmi A. [0000-0001-8020-019X], Akdis, Mubeccel [0000-0003-0554-9943], Barcik, Weronika [0000-0001-8580-9690], Brough, Helen [0000-0001-7203-0813], Eiwegger, Thomas [0000-0002-2914-7829], Eliaszewicz, Andrzej [0000-0002-8980-1474], Feleszko, Wojciech [0000-0001-6613-2012], Gómez-Casado, C. [0000-0002-7707-6367], Hoffmann-Sommergruber, Karin [0000-0002-8830-058X], Janda, Jozef [0000-0001-9958-5683], Jiménez Saiz, Rodrigo [0000-0002-0606-3251], Knol, Edward [0000-0001-7368-9820], Krohn, Kortekaas [0000-0003-3649-1131], Kothari, Akash [0000-0003-1980-161X], Moniuszko, Marcin [0000-0001-7183-3120], Morita, Hideaki [0000-0003-0928-8322], Nadeau, Kari C. [0000-0002-2146-2955], Ozdemir, Cevdet [0000-0002-9284-4520], Pali-Schöll, Isabella [0000-0003-2089-6011], Palomares, O. [0000-0003-4516-0369], Papaleo, Francesco [0000-0002-6326-0657], Prunicki, Mary [0000-0002-5511-8896], Schmidt-Weber, C. B. [0000-0002-3203-8084], Schwarze, Jürgen [0000-0002-6899-748X], Tramper-Stranders, Gerdien [0000-0002-0228-5375], Veen, Willem van de [0000-0001-9951-6688], and Untersmayr, Eva [0000-0002-1963-499X]

Subjects
medicine.medical_specialty, Allergy, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Pneumonia, Viral, Eaaci Position Paper, SARS‐CoV‐2 receptors, Disease, medicine.disease_cause, COVID‐19 treatment, 03 medical and health sciences, Betacoronavirus, COVID‐19 prevention, 0302 clinical medicine, Immune system, COVID-19 Testing, Pandemic, medicine, Immunology and Allergy, Humans, Intensive care medicine, Pandemics, Coronavirus, SARS, business.industry, Clinical Laboratory Techniques, SARS-CoV-2, Academies and Institutes, COVID‐19 comorbidity, COVID-19, biochemical phenomena, metabolism, and nutrition, Acquired immune system, medicine.disease, 3. Good health, 030228 respiratory system, COVID‐19 immunity, COVID‐19 multi‐morbidity, business, Coronavirus Infections, 030215 immunology
Abstract

With the worldwide spread of the novel Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) resulting in declaration of a pandemic by the World Health Organization (WHO) on March 11, 2020, the SARS‐CoV‐2‐induced Coronavirus disease‐19 (COVID‐19) has become one of the main challenges of our times. The high infection rate and the severe disease course led to major safety and social restriction measures worldwide. There is an urgent need of unbiased expert knowledge guiding the development of efficient treatment and prevention strategies. This report summarizes current immunological data on mechanisms associated with the SARS‐CoV‐2 infection and COVID‐19 development and progression to the most severe forms. We characterize the differences between adequate innate and adaptive immune response in mild disease and the deep immune dysfunction in the severe multi‐organ disease. The similarities of the human immune response to SARS‐CoV‐2 and the SARS‐CoV and MERS‐CoV are underlined. We also summarize known and potential SARS‐CoV‐2 receptors on epithelial barriers, immune cells, endothelium and clinically involved organs such as lung, gut, kidney, cardiovascular and neuronal system. Finally, we discuss the known and potential mechanisms underlying the involvement of comorbidities, gender and age in development of COVID‐19. Consequently, we highlight the knowledge gaps and urgent research requirements to provide a quick roadmap for ongoing and needed COVID‐19 studies., The authors would like to thank the European Academy of Allergy and Clinical Immunology (EAACI) for the financial support to the sections, interest groups and working groups enabling the development of this paper. The research of SM is supported by a SNSF grant 310039_189334; JSR is funded by Ministerio de Economía y Competitividad (IJCI-2016-27619); KKI is supported by the FWO Post doc mandate 12W2219N; BW and PF were supported by funding from the Istituto Italiano di Tecnologia, Fondazione Telethon (project GGP19103), and Ricerca Finalizzata Giovani Ricercatori 2016 - Ministero Salute Italia (project GR-2016-02362413); GCC is supported by a postdoctoral contract cofounded by the competitive Program “Attracting Talent,” Community of Madrid, Spain; the research of SWCB was funded by DFG (398577603), “ADAPT” EIT Health is a body of the EU receiving support from H2020 and BMBF “ESCAPE” 01KI20169A; the research of UE is supported by the H2020 grant 768641 and by the BMF grant 19056.

Published
2020

5. Cow's milk protein β-lactoglobulin confers resilience against allergy by targeting complexed iron into immune cells

Author

Alessandro Fiocchi, Frank A. Redegeld, Andreas Regner, Eva Untersmayr, Luis F. Pacios, Erika Jensen-Jarolim, Bart R. Blokhuis, Zdenek Dvorak, Karin Hufnagl, Lisa-Marie Petje, Isabella Pali-Schöll, Sheriene Moussa Afify, Franziska Roth-Walter, Austrian Science Fund, Biomedical International R+D GmbH, Bencard Allergie GmbH, Ministry of Higher Education & Scientific Research (Egypt), Roth-Walter, Franziska [0000-0001-5005-9228], Afify, Sheriene Moussa [0000-0003-2082-9038], Pacios, Luis F [0000-0002-0585-4289], Redegeld, Frank [0000-0001-8830-7960], Fiocchi, Alessandro [0000-0002-2549-0523], Untersmayr, Eva [0000-0002-1963-499X], Hufnagl, Karin [0000-0002-2288-2468], Pali-Schöll, Isabella [0000-0003-2089-6011], Jensen-Jarolim, Erika [0000-0003-4019-5765], Roth-Walter, Franziska, Afify, Sheriene Moussa, Pacios, Luis F, Redegeld, Frank, Fiocchi, Alessandro, Untersmayr, Eva, Hufnagl, Karin, Pali-Schöll, Isabella, Jensen-Jarolim, Erika, Afd Pharmacology, and Pharmacology

Subjects
0301 basic medicine, Allergy, Milk allergy, Lipocalin, Lactoglobulins, Immunoglobulin E, ligand, quercetin, Allergic sensitization, Mice, 0302 clinical medicine, iron, Immunology and Allergy, Mast Cells, Cow's milk, Mice, Inbred BALB C, milk, tolerance, biology, Chemistry, Allergen, Degranulation, Mast cell, BLG, Interleukin 10, medicine.anatomical_structure, Milk, Quercetin, lipocalin, Iron, Antigen presentation, Immunology, Ligand, β-lactoglobulin, 03 medical and health sciences, Immune system, medicine, Animals, Humans, medicine.disease, allergy, Bos d 5, cow's milk, 030104 developmental biology, 030228 respiratory system, biology.protein, Leukocytes, Mononuclear, Cattle, Milk Hypersensitivity, Tolerance
Abstract

Departamento de Biotecnología (INIA), Beta-lactoglobulin (BLG) is a bovine lipocalin in milk with an innate defense function. The circumstances under which BLG is associated with tolerance of or allergy to milk are not understood., Supported by the Austrian Science Fund FWF (grant SFB F4606-B28 ) and in part by Biomedical International R+D GmbH, Vienna, Austria, and by Bencard Allergie GmbH, Munich, Germany. S.M.A. was supported by a grant from the Egyptian Ministry of Higher Education ., 18 Pág.

Published
2021

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