1. Characterization of partially saturated poly(propylene fumarate) for orthopaedic application.
- Author
-
Peter SJ, Yaszemski MJ, Suggs LJ, Payne RG, Langer R, Hayes WC, Unroe MR, Alemany LB, Engel PS, and Mikos AG
- Subjects
- Bone Cements chemistry, Calorimetry, Differential Scanning, Esterification, Fumarates chemistry, Magnetic Resonance Spectroscopy, Molecular Weight, Polypropylenes chemistry, Propylene Glycol chemistry, Solubility, Spectrometry, Mass, Fast Atom Bombardment, Spectroscopy, Fourier Transform Infrared, Bone Cements chemical synthesis, Fumarates chemical synthesis, Polypropylenes chemical synthesis
- Abstract
A partially saturated linear polyester based on poly(propylene fumarate) (PPF) was synthesized for potential application in filling skeletal defects. The synthesis was carried out according to a two-step reaction scheme. Propylene glycol and fumaryl chloride were first combined to form an intermediate fumaric diester. The intermediate was then subjected to a transesterification to form the PPF-based polymer. This method allowed for production of a polymer with a number average molecular weight up to 1500 and a polydispersity index of 2.8 and below. The polymeric backbone structure was investigated through the use of FTIR and NMR. Kinetic studies of the transesterification allowed mapping of the molecular weight increase with reaction time. The final product was also characterized by thermal and solubility analysis.
- Published
- 1997
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