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Characterization of partially saturated poly(propylene fumarate) for orthopaedic application.
- Source :
-
Journal of biomaterials science. Polymer edition [J Biomater Sci Polym Ed] 1997; Vol. 8 (11), pp. 893-904. - Publication Year :
- 1997
-
Abstract
- A partially saturated linear polyester based on poly(propylene fumarate) (PPF) was synthesized for potential application in filling skeletal defects. The synthesis was carried out according to a two-step reaction scheme. Propylene glycol and fumaryl chloride were first combined to form an intermediate fumaric diester. The intermediate was then subjected to a transesterification to form the PPF-based polymer. This method allowed for production of a polymer with a number average molecular weight up to 1500 and a polydispersity index of 2.8 and below. The polymeric backbone structure was investigated through the use of FTIR and NMR. Kinetic studies of the transesterification allowed mapping of the molecular weight increase with reaction time. The final product was also characterized by thermal and solubility analysis.
- Subjects :
- Bone Cements chemistry
Calorimetry, Differential Scanning
Esterification
Fumarates chemistry
Magnetic Resonance Spectroscopy
Molecular Weight
Polypropylenes chemistry
Propylene Glycol chemistry
Solubility
Spectrometry, Mass, Fast Atom Bombardment
Spectroscopy, Fourier Transform Infrared
Bone Cements chemical synthesis
Fumarates chemical synthesis
Polypropylenes chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0920-5063
- Volume :
- 8
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of biomaterials science. Polymer edition
- Publication Type :
- Academic Journal
- Accession number :
- 9342654
- Full Text :
- https://doi.org/10.1163/156856297x00074