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3. Surgery for benign insulinoma: An international review

Author

Department of Surgery, University Hospital, Marburg, Federal Republic of Germany; Department of Surgery, University Hospital, Torino, Italy; Department of Surgery, University Hospital, G??ttingen, Federal Republic of Germany; Department of Surgery, University Hospital, Lille, France; Department of Surgery, University Hospital, D??sseldorf, Federal Republic of Germany; Department of Surgery, University Hospital, Mainz, Federal Republic of Germany; Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA; 4th Department of Surgery, Rome, Italy; Department of Surgery, Washington University, St. Louis, Missouri, USA; Department of Surgery, The Royal Victoria Infirmary, Newcastle upon Tyne, Newcastle upon Tyne, England, UK; Department of Surgery, The George Washington University Medical Center, Washington, D.C., USA; Department of Surgery, University Hospital, Uppsala, Sweden; Department of Surgery, University Hospital, Heidelberg, Federal Republic of Germany; Department of Surgery, University of Chicago, Chicago, Illinois, USA; Department of Surgery, University Hospital, Z??rich, Switzerland, Department of Surgery, University Hospital, Marburg, Federal Republic of Germany; Department of Surgery, University Hospital, Torino, Italy; Department of Surgery, University Hospital, G??ttingen, Federal Republic of Germany; Department of Surgery, University Hospital, Lille, France; Department of Surgery, University Hospital, D??sseldorf, Federal Republic of Germany; Department of Surgery, University Hospital, Mainz, Federal Republic of Germany; Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA; Department of Surgery, Philipps-University, Baidingerstra??e, 3550, Marburg/Lahn, Federal Republic of Germany; 4th Department of Surgery, Rome, Italy; Department of Surgery, Washington University, St. Louis, Missouri, USA; Department of Surgery, The Royal Victoria Infirmary, Newcastle upon Tyne, Newcastle upon Tyne, England, UK; Department of Surgery, The George Washington University Medical Center, Washington, D.C., USA; Department of Surgery, University Hospital, Uppsala, Sweden; Department of Surgery, University Hospital, Heidelberg, Federal Republic of Germany; Department of Surgery, University of Chicago, Chicago, Illinois, USA; Department of Surgery, University Hospital, Z??rich, Switzerland, Ann Arbor, Herfarth, Christian, K??mmerle, Fritz, R??her, Hans-Dietrich, Geelhoed, Glenn W., Rothmund, Matthias, Heerden, Jon A., Angelini, Lucio, Thompson, Norman W., Morino, Francesco, R??ckert, Klaus, Largiader, Felix, Grama, Dimitrie, Proye, Charles, Peiper, Hans-J??rgen, Kaplan, Edwin L., Brunt, L. Michael, Farndon, John R., Department of Surgery, University Hospital, Marburg, Federal Republic of Germany; Department of Surgery, University Hospital, Torino, Italy; Department of Surgery, University Hospital, G??ttingen, Federal Republic of Germany; Department of Surgery, University Hospital, Lille, France; Department of Surgery, University Hospital, D??sseldorf, Federal Republic of Germany; Department of Surgery, University Hospital, Mainz, Federal Republic of Germany; Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA; 4th Department of Surgery, Rome, Italy; Department of Surgery, Washington University, St. Louis, Missouri, USA; Department of Surgery, The Royal Victoria Infirmary, Newcastle upon Tyne, Newcastle upon Tyne, England, UK; Department of Surgery, The George Washington University Medical Center, Washington, D.C., USA; Department of Surgery, University Hospital, Uppsala, Sweden; Department of Surgery, University Hospital, Heidelberg, Federal Republic of Germany; Department of Surgery, University of Chicago, Chicago, Illinois, USA; Department of Surgery, University Hospital, Z??rich, Switzerland, Department of Surgery, University Hospital, Marburg, Federal Republic of Germany; Department of Surgery, University Hospital, Torino, Italy; Department of Surgery, University Hospital, G??ttingen, Federal Republic of Germany; Department of Surgery, University Hospital, Lille, France; Department of Surgery, University Hospital, D??sseldorf, Federal Republic of Germany; Department of Surgery, University Hospital, Mainz, Federal Republic of Germany; Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA; Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA; Department of Surgery, Philipps-University, Baidingerstra??e, 3550, Marburg/Lahn, Federal Republic of Germany; 4th Department of Surgery, Rome, Italy; Department of Surgery, Washington University, St. Louis, Missouri, USA; Department of Surgery, The Royal Victoria Infirmary, Newcastle upon Tyne, Newcastle upon Tyne, England, UK; Department of Surgery, The George Washington University Medical Center, Washington, D.C., USA; Department of Surgery, University Hospital, Uppsala, Sweden; Department of Surgery, University Hospital, Heidelberg, Federal Republic of Germany; Department of Surgery, University of Chicago, Chicago, Illinois, USA; Department of Surgery, University Hospital, Z??rich, Switzerland, Ann Arbor, Herfarth, Christian, K??mmerle, Fritz, R??her, Hans-Dietrich, Geelhoed, Glenn W., Rothmund, Matthias, Heerden, Jon A., Angelini, Lucio, Thompson, Norman W., Morino, Francesco, R??ckert, Klaus, Largiader, Felix, Grama, Dimitrie, Proye, Charles, Peiper, Hans-J??rgen, Kaplan, Edwin L., Brunt, L. Michael, and Farndon, John R.

Abstract

In a multiinstitutional review, data on 396 patients with benign solitary or multiple insulinomas operated on in 15 centers were collected. In these 396 patients, 419 laparotomies (375 primary procedures and 44 reoperations) were performed. The rate of unnecessary laparotomies was 1.7%. Complications occurred after 132 operations (31.5%), requiring 27 reinterventions (6.4%). Ten (2%) patients died within 30 days of surgery. The success rate of first procedures in the centers was 94.9%. After reoperation, all but 2 (99.5%) of these patients were cured. The overall cure rate including those patients who had their primary operations elsewhere was 97.5% . Compilant les dossiers de 15??tablissements internationaux, nous avons collig?? les donn??es concernant 396 patients pr??sentant un insulinome b??nin unique ou multiple, op??r??s. Chez ces 396 patients, 419 laparotomies (375 interventions de premi??re intention et 44 reprises) ont??t?? effectu??es. Le taux de laparotomie inutile??tait de 1.7%. Des complications sont intervenues?? la suite de 132 op??rations (31.5%), n??cessitant 27 r??interventions (6.4%). Dix (2%) patients sont morts dans les trente jours apr??s l'acte chirurgical. Le taux de succ??s des interventions de premi??re intention dans les centres de l'??tude??tait de 94.9%. Apr??s r??interventions, tous les patients sauf 2 (99.5%) ont??t?? gu??ris. Le taux global de gu??rison, y compris les patients ayant??t?? op??r??s une premi??re fois ailleurs,??tait de 97.5%. En una revisi??n multiinstitucional se recolectaron los datos sobre 396 pacientes con insulinomas benignos solitarios o m??ltiples operados en 15 centros. En estos 396 pacientes se efectuaron 419 laparotom??as (375 procedimientos primarios y 44 reoperaciones). Se registr?? una tasa de laparotom??as innecesarias de 1.7%; se presentaron complicaciones despu??s de 132 operaciones (31.5%), las cuales requirieron 27 reintervenciones (6.4%). Diez (2%) pacientes murieron dentro de los primeras 30

Published
2006

6. Genome-wide evolutionary response of European oaks since the Little Ice Age

Author

Dounia Saleh, Jean-Marc Aury, Jun Chen, Thibault Leroy, Karine Labadie, Didier Bert, François Morneau, Frédéric Lagane, Céline Lalanne, Martin Lascoux, Jean-Charles Leplé, Benjamin Dencausse, Isabelle Lesur, Christophe Plomion, Laura Truffaut, Antoine Kremer, Biodiversité, Gènes & Communautés (BioGeCo), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), College of Life Sciences, Zhejiang University, University of Vienna, Genoscope, Institut de Biologie François Jacob, Commissariat à l’énergie atomique (CEA), Université de Paris-Saclay, 2 rue Gaston Crémieux, 91057 Evry, France, HelixVenture, Département Recherche Développement Innovation, Office National des Forêts, 100 Boulevard de la Salle, 45760 Boigny-Sur-Bionne, France, Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, 91057 Evry, France, Department of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, 75236 Uppsala, Sweden, Génomique métabolique (UMR 8030), Genoscope - Centre national de séquençage [Evry] (GENOSCOPE), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), and Uppsala University

Subjects
0106 biological sciences, Abiotic component, 0303 health sciences, Ecology, [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], Quercus petraea, Microevolution, 15. Life on land, Biology, Linked selection, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Genome, 03 medical and health sciences, 13. Climate action, Frost, evolution, Little Ice Age, sense organs, Little ice age, Allele frequency, Selection (genetic algorithm), 030304 developmental biology
Abstract

The pace of tree microevolution during Anthropocene warming is largely unknown. We used a retrospective approach to monitor genomic changes in oak trees since the Little Ice Age (LIA). Allelic frequency changes were assessed from whole-genome pooled sequences for four age-structured cohorts of sessile oak (Quercus petraea) dating back to 1680, in each of three different oak forests in France. The genetic covariances of allelic frequency changes increased between successive time periods, highlighting genome-wide effects of linked selection. We found imprints of convergent linked selection in the three forests during the late LIA, and a shift of selection during more recent time periods. The changes in allelic covariances within and between forests mirrored the documented changes in the occurrence of extreme events (droughts and frosts) over the last three hundred years. The genomic regions with the highest covariances were enriched in genes involved in plant responses to pathogens and abiotic stresses (temperature and drought). These responses are consistent with the reported sequence of frost (or drought) and disease damage ultimately leading to the oak dieback after extreme events. Our results therefore provide evidence of selection operating on long-lived species during recent climatic changes.

Published
2021

21. NEDA—NEutron Detector Array

Author

Valiente-Dobón, J. J., Jaworski, G., Goasduff, A., Egea, F. J., Modamio, V., Hüyük, T., Triossi, A., Jastrząb, M., Söderström, P. A., Di Nitto, A., de Angelis, G., de France, G., Erduran, N., Gadea, A., Moszyński, M., Nyberg, J., Palacz, M., Wadsworth, R., Aliaga, R., Aufranc, C., Bézard, M., Baulieu, G., Bissiato, E., Boujrad, A., Burrows, I., Carturan, S., Cocconi, P., Colucci, G., Conventi, D., Cordwell, M., Coudert, S., Deltoro, J. M., Ducroux, L., Dupasquier, T., Ertürk, S., Fabian, X., González, V., Grant, A., Hadyńska-Klęk, K., Illana, A., Jurado-Gomez, M. L., Kogimtzis, M., Lazarus, I., Legeard, L., Ljungvall, J., Pasqualato, G., Pérez-Vidal, R. M., Raggio, A., Ralet, D., Redon, N., Saillant, F., Sayğı, B., Sanchis, E., Scarcioffolo, M., Siciliano, M., Testov, D., Stezowski, O., Tripon, M., Zanon, I., Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Valiente-Dobón, J.J., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Jaworski, G., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Goasduff, A., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Egea, F.J., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy, Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Modamio, V., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Department of Physics, University of Oslo, Oslo, N-0316, Norway -- Hüyük, T., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Triossi, A., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy, CERN, Switzerland -- Jastrzab, M., Niewodniczanski Institute of Nuclear Physics, Polish Academy of Sciences, Kraków, Poland -- Söderström, P.A., Extreme Light Infrastructureuclear Physics (ELI-NP), 077125 Bucharest-Magurele, Romania -- Di Nitto, A., Helmholtz Institute Mainz and GSI Helmholtzzentrum für Schwerionenforschund, Darmstadt, Germany -- de Angelis, G., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- de France, G., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Erduran, N., Faculty of Engineering and Natural Sciences, Istanbul Sabahattin Zaim University, Istanbul, 34303, Turkey -- Gadea, A., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Moszynski, M., National Centre for Nuclear Research, 05-400 Otwock-Swierk, Poland -- Nyberg, J., Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala, Sweden -- Palacz, M., Heavy Ion Laboratory, University of Warsaw, Warsaw, 02-093, Poland -- Wadsworth, R., Department of Physics, University of York, Heslington, YO10 5DD York, United Kingdom -- Aliaga, R., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Aufranc, C., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Bézard, M., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Baulieu, G., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Bissiato, E., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Boujrad, A., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Burrows, I., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Carturan, S., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy -- Cocconi, P., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Colucci, G., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Conventi, D., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Cordwell, M., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Coudert, S., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Deltoro, J.M., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Ducroux, L., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Dupasquier, T., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Ertürk, S., Department of Physics, Nigde Omer Halisdemir University, Nigde, 51240, Turkey -- Fabian, X., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- González, V., Departamento de Ingeniería Electrónica, Universidad de Valencia. Avda. Universidad s/n, Burjassot, 46100, Spain -- Grant, A., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Hadynska-Klek, K., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Department of Physics, University of Surrey, Guildford, GU2 7XH, United Kingdom -- Illana, A., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Jurado-Gomez, M.L., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Kogimtzis, M., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Lazarus, I., STFC Daresbury Laboratory, Daresbury, Warrington, WA4 4AD, United Kingdom -- Legeard, L., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Ljungvall, J., CSNSM, CNRS, IN2P3, Université Paris-Sud, Orsay, F-91405, France -- Pasqualato, G., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Pérez-Vidal, R.M., Instituto de Física Corpuscular, CSIC-Universidad deValencia, E-46980 Paterna (Valencia), Spain -- Raggio, A., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Ralet, D., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Redon, N., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Saillant, F., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Sayğı, B., Department of Physics, Faculty of Science, University of Ege, Izmir, 35100, Turkey -- Sanchis, E., Departamento de Ingeniería Electrónica, Universidad de Valencia. Avda. Universidad s/n, Burjassot, 46100, Spain -- Scarcioffolo, M., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Siciliano, M., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy -- Testov, D., Dipartimento di Fisica e Astronomia, Università di Padova, Padova, Italy, Istituto Nazionale di Fisica Nucleare, Sezione di Padova, Università di Padova, Padova, Italy -- Stezowski, O., Université Lyon 1, CNRS, IN2P3, IPN Lyon, Villeurbanne, F-69622, France -- Tripon, M., GANIL, CEA/DRF-CNRS/IN2P3, Bvd. Henri Becquerel, Caen, 14076, France -- Zanon, I., Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro, Legnaro, Italy, Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), 0-Belirlenecek, Ege Üniversitesi, Valiente-Dobón, J. J., Jaworski, G., Goasduff, A., Egea, F. J., Modamio, V., Hüyük, T., Triossi, A., Jastrząb, M., Söderström, P. A., Di Nitto, A., de Angelis, G., de France, G., Erduran, N., Gadea, A., Moszyński, M., Nyberg, J., Palacz, M., Wadsworth, R., Aliaga, R., Aufranc, C., Bézard, M., Baulieu, G., Bissiato, E., Boujrad, A., Burrows, I., Carturan, S., Cocconi, P., Colucci, G., Conventi, D., Cordwell, M., Coudert, S., Deltoro, J. M., Ducroux, L., Dupasquier, T., Ertürk, S., Fabian, X., González, V., Grant, A., Hadyńska-Klęk, K., Illana, A., Jurado-Gomez, M. L., Kogimtzis, M., Lazarus, I., Legeard, L., Ljungvall, J., Pasqualato, G., Pérez-Vidal, R. M., Raggio, A., Ralet, D., Redon, N., Saillant, F., Sayğı, B., Sanchis, E., Scarcioffolo, M., Siciliano, M., Testov, D., Stezowski, O., Tripon, M., and Zanon, I.

Subjects
Nuclear and High Energy Physics, Neutron-gamma discrimination, Liquid scintillator, 010308 nuclear & particles physics, Astrophysics::High Energy Astrophysical Phenomena, Neutron detector, Digital electronic, NEDA, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 16. Peace & justice, Digital electronics, 01 natural sciences, 0103 physical sciences, Nuclear structure, Gamma-ray spectroscopy, 010306 general physics, Nuclear Experiment, Instrumentation, Nuclear and High Energy Physic
Abstract

Millan, Vicente Gonzalez/0000-0001-6014-2586; Huyuk, Tayfun/0000-0003-0597-9767; GOASDUFF, Alain/0000-0003-3453-3297; carturan, sara maria/0000-0002-6702-2867; Sison, Andres Illana/0000-0003-0274-3388; SAYGI, BAHADIR/0000-0001-5406-506X; Jaworski, Grzegorz/0000-0003-2241-0329; Aliaga, Ramon J./0000-0002-2513-7711; Vidal, Rosa Maria Perez/0000-0002-4075-4152; Di Nitto, Antonio/0000-0002-9319-366X; Lazarus, Ian/0000-0003-1235-4984; Hadynska Klek, Katarzyna/0000-0003-1244-9561; Sanchis Peris, Enrique/0000-0002-9689-9131; Moszynski, Marek/0000-0002-1267-2838; Soderstrom, Par-Anders/0000-0002-9504-2814, WOS: 000462142700010, The NEutron Detector Array, NEDA, will form the next generation neutron detection system that has been designed to be operated in conjunction with gamma-ray arrays, such as the tracking-array AGATA, to aid nuclear spectroscopy studies. NEDA has been designed to be a versatile device, with high-detection efficiency, excellent neutron-gamma discrimination, and high rate capabilities. It will be employed in physics campaigns in order to maximise the scientific output, making use of the different stable and radioactive ion beams available in Europe. the first implementation of the neutron detector array NEDA with AGATA 1 pi was realised at GANIL. This manuscript reviews the various aspects of NEDA., Swedish Research Council, SwedenSwedish Research Council [VR 2014-6644]; Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [117F114, 114F473]; Polish National Science Centre, Poland [2017/25/B/ST2/01569, 2016/22/M/ST2/00269 COPIN-IN2P3]; COPIGAL projects, Poland; UK STFCScience & Technology Facilities Council (STFC) [ST/J000124/1, ST/L005727/1, STL005735/1, ST/P003885/1]; Generalitat ValencianaGeneralitat Valenciana [PROMETEO II/2014/019, FPA2017-84756-C4]; MICIU, Spain [PROMETEO II/2014/019, FPA2017-84756-C4]; Severo Ochoa, Spain [SEV-2014-0398]; E.C. FEDER, Spain funds, This study is supported by the Swedish Research Council, Sweden (contract number VR 2014-6644), the Scientific and Technological Research Council of Turkey (TUBITAK Project No: 117F114 and 114F473), the Polish National Science Centre, Poland, grants nos. 2017/25/B/ST2/01569 and 2016/22/M/ST2/00269 COPIN-IN2P3 and COPIGAL projects, Poland, the UK STFC under grant nos. (ST/J000124/1, ST/L005727/1, STL005735/1, ST/P003885/1), the Generalitat Valenciana and MICIU, Spain, grants PROMETEO II/2014/019, FPA2017-84756-C4, Severo Ochoa, Spain SEV-2014-0398 and by the E.C. FEDER, Spain funds.

Published
2019
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22. Pathways to electrochemical solar-hydrogen technologies

Author

Eric L. Miller, Valerio Di Palma, Maureen H. Tang, Shane Ardo, Alan Berger, Francesco Buda, Katherine E. Ayers, Stafford W. Sheehan, Enrico Chinello, Han Gardeniers, Kornelia Konrad, Jurriaan Huskens, Brian D. James, Katsushi Fujii, S. Mohammad H. Hashemi, Jan Willem Schüttauf, David Fernandez Rivas, Timothy E. Rosser, Brian Seger, Fatwa F. Abdi, Peter Christian Kjærgaard Vesborg, Dmytro Bederak, Verena Schulze Greiving, Pieter Westerik, Bernard Dam, Hans Geerlings, Detlef Lohse, Miguel A. Modestino, Katherine L. Orchard, Frances A. Houle, Tomas Edvinsson, Akihiko Kudo, Wilson A. Smith, Esther Alarcon Llado, Bastian Mei, Jan-Philipp Becker, Fadl H. Saadi, Corsin Battaglia, Gary F. Moore, Jiri Muller, Roel van de Krol, Joshua M. Spurgeon, Vincent Artero, Sophia Haussener, Pramod Patil Kunturu, Department of Chemistry [Irvine], University of California [Irvine] (UCI), University of California-University of California, Department of Chemical Engineering and Materials Science, Institute for Nanotechnology (MESA+), University of Twente [Netherlands], Mesoscale Chemical Systems Group, New York University [New York] (NYU), NYU System (NYU), Department of Science, Technology, Health and Policy Studies, Institute for Solar Fuels [Berlin], Helmholtz-Zentrum Berlin für Materialien und Energie GmbH (HZB), Center for Nanophotonics, FOM Institute for Atomic and Molecular Physics (AMOLF), Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Proton OnSite, Wallingford, USA, Swiss Federal Laboratories for Materials Science and Technology [Dübendorf] (EMPA), Institut für Energie- und Klimaforschung - Photovoltaik (IEK-5), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Zernike Institute for Advanced Materials, University of Groningen [Groningen], Air Products and Chemicals, Inc (AIR PRODUCTS AND CHEMICALS), Air Products and Chemicals, Inc., Leiden Institute of Chemistry, Universiteit Leiden [Leiden], Ecole Polytechnique Fédérale de Lausanne (EPFL), Delft University of Technology (TU Delft), Department of Applied Physics [Eindhoven], Eindhoven University of Technology [Eindhoven] (TU/e), Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, SE-75121 Uppsala, Sweden, University of Kitakyushu, Institute of Environmental Science and Technology, Wakamatsu-ku, Kitakyushu, Japan, MESA+ Institute for Nanotechnology, Chemical Sciences Division [LBNL Berkeley] (CSD), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Molecular Nanofabrication Group, Enschede, Strategic Analysis Inc, Tokyo University of Science [Tokyo], Physics of Fluids Group, Photocatalytic Synthesis Group, Office of Energy Efficiency and Renewable Energy, Advanced Manufacturing Office (EERE), Division of Engineering and Applied Science, California Institute of Technology, California Institute of Technology (CALTECH), Plasma & Materials Processing, Mesoscale Chemical Systems, Molecular Nanofabrication, Physics of Fluids, Photocatalytic Synthesis, University of California [Irvine] (UC Irvine), University of California (UC)-University of California (UC), University of Twente, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Universiteit Leiden, and Uppsala University

Subjects
EFFICIENCY, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Process (engineering), Solar hydrogen, WATER-SPLITTING SYSTEMS, Bioengineering, Energy Engineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, 7. Clean energy, Energy engineering, solar fuels, solar chemical technologies, Affordable and Clean Energy, MD Multidisciplinary, Environmental Chemistry, Production (economics), NEAR-NEUTRAL PH, SDG 7 - Affordable and Clean Energy, PHOTOVOLTAIC-ELECTROLYSIS, RENEWABLE ENERGY, Power to gas, Energy, Renewable Energy, Sustainability and the Environment, business.industry, LOW-COST, DRIVEN, Environmental economics, 021001 nanoscience & nanotechnology, Pollution, ARTIFICIAL PHOTOSYNTHESIS, 0104 chemical sciences, Renewable energy, Energiteknik, Nuclear Energy and Engineering, 13. Climate action, [SDE]Environmental Sciences, POWER-TO-GAS, Technology roadmap, Business, 0210 nano-technology, Polymer electrolyte membrane electrolysis, SDG 7 – Betaalbare en schone energie, PEM ELECTROLYSIS
Abstract

© 2018 The Royal Society of Chemistry. Solar-powered electrochemical production of hydrogen through water electrolysis is an active and important research endeavor. However, technologies and roadmaps for implementation of this process do not exist. In this perspective paper, we describe potential pathways for solar-hydrogen technologies into the marketplace in the form of photoelectrochemical or photovoltaic-driven electrolysis devices and systems. We detail technical approaches for device and system architectures, economic drivers, societal perceptions, political impacts, technological challenges, and research opportunities. Implementation scenarios are broken down into short-term and long-term markets, and a specific technology roadmap is defined. In the short term, the only plausible economical option will be photovoltaic-driven electrolysis systems for niche applications. In the long term, electrochemical solar-hydrogen technologies could be deployed more broadly in energy markets but will require advances in the technology, significant cost reductions, and/or policy changes. Ultimately, a transition to a society that significantly relies on solar-hydrogen technologies will benefit from continued creativity and influence from the scientific community.

Published
2018
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23. Amine-functionalised mesoporous magnesium carbonate: Dielectric spectroscopy studies of interactions with water and stability

Author

Maria Strømme, Isabelle Pochard, Joakim Eriksson, Ocean Cheung, Maria Vall, Camille Farineau, Ken Welch, Sara Frykstrand, Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, SE-75121 Uppsala, Sweden, Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Department of Engineering Sciences, and Uppsala University

Subjects
Solid-state chemistry, Materials science, Magnesium, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, 0104 chemical sciences, Dielectric spectroscopy, chemistry, Chemical engineering, [CHIM]Chemical Sciences, General Materials Science, Amine gas treating, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 0210 nano-technology, Mesoporous material, ComputingMilieux_MISCELLANEOUS
Abstract

A mesoporous magnesium carbonate (MMC) material that was first described in 2013 is currently being investigated for several industrial and life-science-based applications. In this paper, the effec ...

Published
2018
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26. Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

Author

Ezzati, M. and Zhou, B. and Bentham, J. and Di Cesare, M. and Bixby, H. and Danaei, G. and Hajifathalian, K. and Taddei, C. and Carrillo-Larco, R.M. and Djalalinia, S. and Khatibzadeh, S. and Lugero, C. and Peykari, N. and Zhang, W.Z. and Bennett, J. and Bilano, V. and Stevens, G.A. and Cowan, M.J. and Riley, L.M. and Chen, Z. and Hambleton, I.R. and Jackson, R.T. and Kengne, A.P. and Khang, Y.-H. and Laxmaiah, A. and Liu, J. and Malekzadeh, R. and Neuhauser, H.K. and Sorić, M. and Starc, G. and Sundström, J. and Woodward, M. and Abarca-Gómez, L. and Abdeen, Z.A. and Abu-Rmeileh, N.M. and Acosta-Cazares, B. and Adams, R.J. and Aekplakorn, W. and Afsana, K. and Aguilar-Salinas, C.A. and Agyemang, C. and Ahmad, N.A. and Ahmadvand, A. and Ahrens, W. and Ajlouni, K. and Akhtaeva, N. and Al-Raddadi, R. and Ali, M.M. and Ali, O. and Alkerwi, A. and Aly, E. and Amarapurkar, D.N. and Amouyel, P. and Amuzu, A. and Andersen, L.B. and Anderssen, S.A. and Ängquist, L.H. and Anjana, R.M. and Ansong, D. and Aounallah-Skhiri, H. and Araújo, J. and Ariansen, I. and Aris, T. and Arlappa, N. and Arveiler, D. and Aryal, K.K. and Aspelund, T. and Assah, F.K. and Assunção, M.C.F. and Avdicová, M. and Azevedo, A. and Azizi, F. and Babu, B.V. and Bahijri, S. and Balakrishna, N. and Bamoshmoosh, M. and Banach, M. and Bandosz, P. and Banegas, J.R. and Barbagallo, C.M. and Barceló, A. and Barkat, A. and Barros, A.J.D. and Barros, M.V. and Bata, I. and Batieha, A.M. and Batyrbek, A. and Baur, L.A. and Beaglehole, R. and Romdhane, H.B. and Benet, M. and Benson, L.S. and Bernabe-Ortiz, A. and Bernotiene, G. and Bettiol, H. and Bhagyalaxmi, A. and Bharadwaj, S. and Bhargava, S.K. and Bi, Y. and Bikbov, M. and Bista, B. and Bjerregaard, P. and Bjertness, E. and Bjertness, M.B. and Björkelund, C. and Blokstra, A. and Bo, S. and Bobak, M. and Boeing, H. and Boggia, J.G. and Boissonnet, C.P. and Bongard, V. and Borchini, R. and Bovet, P. and Braeckman, L. and Brajkovich, I. and Branca, F. and Breckenkamp, J. and Brenner, H. and Brewster, L.M. and Bruno, G. and Bueno-de-Mesquita, H.B. and Bugge, A. and Burns, C. and Bursztyn, M. and de León, A.C. and Cacciottolo, J. and Cai, H. and Cameron, C. and Can, G. and Cândido, A.P.C. and Capuano, V. and Cardoso, V.C. and Carlsson, A.C. and Carvalho, M.J. and Casanueva, F.F. and Casas, J.-P. and Caserta, C.A. and Chamukuttan, S. and Chan, A.W. and Chan, Q. and Chaturvedi, H.K. and Chaturvedi, N. and Chen, C.-J. and Chen, F. and Chen, H. and Chen, S. and Cheng, C.-Y. and Dekkaki, I.C. and Chetrit, A. and Chiolero, A. and Chiou, S.-T. and Chirita-Emandi, A. and Chirlaque, M.-D. and Cho, B. and Cho, Y. and Christofaro, D.G. and Chudek, J. and Cifkova, R. and Cinteza, E. and Claessens, F. and Clays, E. and Concin, H. and Cooper, C. and Cooper, R. and Coppinger, T.C. and Costanzo, S. and Cottel, D. and Cowell, C. and Craig, C.L. and Crujeiras, A.B. and Cruz, J.J. and D'Arrigo, G. and d'Orsi, E. and Dallongeville, J. and Damasceno, A. and Dankner, R. and Dantoft, T.M. and Dauchet, L. and Davletov, K. and De Backer, G. and De Bacquer, D. and de Gaetano, G. and De Henauw, S. and de Oliveira, P.D. and De Smedt, D. and Deepa, M. and Dehghan, A. and Delisle, H. and Deschamps, V. and Dhana, K. and Di Castelnuovo, A.F. and Dias-da-Costa, J.S. and Diaz, A. and Dickerson, T.T. and Do, H.T.P. and Dobson, A.J. and Donfrancesco, C. and Donoso, S.P. and Döring, A. and Dorobantu, M. and Doua, K. and Drygas, W. and Dulskiene, V. and Džakula, A. and Dzerve, V. and Dziankowska-Zaborszczyk, E. and Eggertsen, R. and Ekelund, U. and El Ati, J. and Elliott, P. and Elosua, R. and Erasmus, R.T. and Erem, C. and Eriksen, L. and Eriksson, J.G. and Escobedo-de la Peña, J. and Evans, A. and Faeh, D. and Fall, C.H. and Farzadfar, F. and Felix-Redondo, F.J. and Ferguson, T.S. and Fernandes, R.A. and Fernández-Bergés, D. and Ferrante, D. and Ferrari, M. and Ferreccio, C. and Ferrieres, J. and Finn, J.D. and Fischer, K. and Föger, B. and Foo, L.H. 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Hospital Italiano de Buenos Aires, Argentina, Lagos State University College of Medicine, Nigeria, The University of Tokyo, Japan, Samsung Medical Center, South Korea, Federal University of Santa Catarina, Brazil, St Vincent's Hospital, Australia, Academic Medical Center Amsterdam, Netherlands, University of Bari, Italy, Lund University, Sweden, University of Copenhagen, Denmark, Institut Régional de Santé Publique, Benin, University of Bordeaux, France, University of Leuven, Belgium, Bonn University, Germany, Sotiria Hospital, Greece, National Institute of Public Health- National Institute of Hygiene, Poland, Fu Jen Catholic University, Taiwan, Ministry of Health, Jordan, Health Service of Murcia, Spain, IB-SALUT Area de Salut de Menorca, Spain, Institut de Recherche pour le Développement, France, Hellenic Health Foundation, Greece, GovernmentMedical College, India, Sefako Makgatho Health Science University, South Africa, Addis Ababa University, Ethiopia, Dasman Diabetes Institute, Kuwait, Ministry of Health, New Zealand, Universidad Centro-Occidental Lisandro Alvarado, Venezuela, University of Tampere Tays Eye Center, Finland, Utrecht University, Netherlands, Hanoi University of Public Health, Viet Nam, Amsterdam Public Health Research Institute, Netherlands, Universidade Federal de Minas Gerais, Brazil, Finnish Institute of Occupational Health, Finland, Universidad Miguel Hernandez, Spain, North Karelian Center for Public Health, Finland, University of the Witwatersrand, South Africa, University of Strasbourg, France, Institute for Medical Research, Malaysia, Xinjiang Medical University, China, Capital Medical University, China, St George's, University of London, United Kingdom, Medical University of Vienna, Austria, Universitas Indonesia, Indonesia, National Institute of Public Health-National Institute of Hygiene, Poland, Institute of Food and Nutrition Development of Ministry of Agriculture, China, Children's Hospital of Fudan University, China, University of Cyprus, Cyprus, Universiti Teknologi MARA, Malaysia, Inner Mongolia Medical University, China, Universidad Politécnica de Madrid, Spain, State University of Montes Claros, Brazil, and University of Limpopo, South Africa

Subjects
sense organs
Abstract

Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups. © The Author(s) 2018.

Published
2018

27. Continuous-Variable Triple-Photon States Quantum Entanglement

Author

E. A. Rojas González, Adrien Borne, Benoît Boulanger, Juan Ariel Levenson, Kamel Bencheikh, University of A Coruña (UDC), Weizmann Institute of Science [Rehovot, Israël], Optique et Matériaux (OPTIMA ), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre de Nanosciences et de Nanotechnologies [Marcoussis] (C2N), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11), and Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, SE-75121 Uppsala, Sweden

Subjects
Physics, Quantum Physics, Quantum discord, Cluster state, General Physics and Astronomy, FOS: Physical sciences, Quantum entanglement, Squashed entanglement, 01 natural sciences, Multipartite entanglement, 010309 optics, Quantum mechanics, 0103 physical sciences, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, W state, 010306 general physics, Amplitude damping channel, Quantum Physics (quant-ph), Quantum teleportation, ComputingMilieux_MISCELLANEOUS
Abstract

We investigate the quantum entanglement of the three modes associated with the three-photon states obtained by triple-photon generation in a phase-matched third-order nonlinear optical interaction. Although the second order processes have been extensively dealt with, there is no direct analogy between the second and third-order mechanisms. We show for example the absence of quantum entanglement between the quadratures of the three modes in the case of spontaneous parametric triple-photon generation. However, we show that genuine triple-photon entanglement is obtained in the fully seeded case, and its efficiency increases with the seeding level.

Published
2017
Full Text
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28. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

Author

Zhou, B. and Bentham, J. and Di Cesare, M. and Bixby, H. and Danaei, G. and Cowan, M.J. and Paciorek, C.J. and Singh, G. and Hajifathalian, K. and Bennett, J.E. and Taddei, C. and Bilano, V. and Carrillo-Larco, R.M. and Djalalinia, S. and Khatibzadeh, S. and Lugero, C. and Peykari, N. and Zhang, W.Z. and Lu, Y. and Stevens, G.A. and Riley, L.M. and Bovet, P. and Elliott, P. and Gu, D. and Ikeda, N. and Jackson, R.T. and Joffres, M. and Kengne, A.P. and Laatikainen, T. and Lam, T.H. and Laxmaiah, A. and Liu, J. and Miranda, J.J. and Mondo, C.K. and Neuhauser, H.K. and Sundström, J. and Smeeth, L. and Sorić, M. and Woodward, M. and Ezzati, M. and Abarca-Gómez, L. and Abdeen, Z.A. and Rahim, H.A. and Abu-Rmeileh, N.M. and Acosta-Cazares, B. and Adams, R. and Aekplakorn, W. and Afsana, K. and Aguilar-Salinas, C.A. and Agyemang, C. and Ahmadvand, A. and Ahrens, W. and Al Raddadi, R. and Al Woyatan, R. and Ali, M.M. and Alkerwi, A. and Aly, E. and Amouyel, P. and Amuzu, A. and Andersen, L.B. and Anderssen, S.A. and Ängquist, L. and Anjana, R.M. and Ansong, D. and Aounallah-Skhiri, H. and Araújo, J. and Ariansen, I. and Aris, T. and Arlappa, N. and Aryal, K. and Arveiler, D. and Assah, F.K. and Assunção, M.C.F. and Avdicová, M. and Azevedo, A. and Azizi, F. and Babu, B.V. and Bahijri, S. and Balakrishna, N. and Bandosz, P. and Banegas, J.R. and Barbagallo, C.M. and Barceló, A. and Barkat, A. and Barros, A.J.D. and Barros, M.V. and Bata, I. and Batieha, A.M. and Baur, L.A. and Beaglehole, R. and Romdhane, H.B. and Benet, M. and Benson, L.S. and Bernabe-Ortiz, A. and Bernotiene, G. and Bettiol, H. and Bhagyalaxmi, A. and Bharadwaj, S. and Bhargava, S.K. and Bi, Y. and Bikbov, M. and Bjerregaard, P. and Bjertness, E. and Björkelund, C. and Blokstra, A. and Bo, S. and Bobak, M. and Boeing, H. and Boggia, J.G. and Boissonnet, C.P. and Bongard, V. and Braeckman, L. and Brajkovich, I. and Branca, F. and Breckenkamp, J. and Brenner, H. and Brewster, L.M. and Bruno, G. and Bueno-de-Mesquita, H.B. and Bugge, A. and Burns, C. and Bursztyn, M. and de León, A.C. and Cacciottolo, J. and Cameron, C. and Can, G. and Cândido, A.P.C. and Capuano, V. and Cardoso, V.C. and Carlsson, A.C. and Carvalho, M.J. and Casanueva, F.F. and Casas, J.-P. and Caserta, C.A. and Chamukuttan, S. and Chan, A.W. and Chan, Q. and Chaturvedi, H.K. and Chaturvedi, N. and Chen, C.-J. and Chen, F. and Chen, H. and Chen, S. and Chen, Z. and Cheng, C.-Y. and Dekkaki, I.C. and Chetrit, A. and Chiolero, A. and Chiou, S.-T. and Chirita-Emandi, A. and Cho, B. and Cho, Y. and Chudek, J. and Cifkova, R. and Claessens, F. and Clays, E. and Concin, H. and Cooper, C. and Cooper, R. and Coppinger, T.C. and Costanzo, S. and Cottel, D. and Cowell, C. and Craig, C.L. and Crujeiras, A.B. and Cruz, J.J. and D'Arrigo, G. and d'Orsi, E. and Dallongeville, J. and Damasceno, A. and Dankner, R. and Dantoft, T.M. and Dauchet, L. and De Backer, G. and De Bacquer, D. and de Gaetano, G. and De Henauw, S. and De 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and Garnett, S.P. and Gaspoz, J.-M. and Gasull, M. and Gates, L. and Gavrila, D. and Geleijnse, J.M. and Ghasemian, A. and Ghimire, A. and Giampaoli, S. and Gianfagna, F. and Giovannelli, J. and Goldsmith, R.A. and Gonçalves, H. and Gross, M.G. and González Rivas, J.P. and Gottrand, F. and Graff-Iversen, S. and Grafnetter, D. and Grajda, A. and Gregor, R.D. and Grodzicki, T. and Grøntved, A. and Gruden, G. and Grujic, V. and Guan, O.P. and Gudnason, V. and Guerrero, R. and Guessous, I. and Guimaraes, A.L. and Gulliford, M.C. and Gunnlaugsdottir, J. and Gunter, M. and Gupta, P.C. and Gureje, O. and Gurzkowska, B. and Gutierrez, L. and Gutzwiller, F. and Hadaegh, F. and Halkjær, J. and Hambleton, I.R. and Hardy, R. and Harikumar, R. and Hata, J. and Hayes, A.J. and He, J. and Hendriks, M.E. and Henriques, A. and Cadena, L.H. and Herqutanto and Herrala, S. and Heshmat, R. and Hihtaniemi, I.T. and Ho, S.Y. and Ho, S.C. and Hobbs, M. and Hofman, A. and Dinc, G.H. and Hormiga, C.M. and 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Netherlands, Research Institute of Child Nutrition, Germany, Seoul National University, South Korea, University of Cambridge, United Kingdom, Medical University of Innsbruck, Austria, Muhimbili University of Health and Allied Sciences, Tanzania, National Cancer Center, South Korea, Institute of Tropical Medicine, Belgium, Tartu University Clinics, Estonia, Polish Academy of Sciences Anthropology Unit in Wroclaw, Poland, University of Groningen, Netherlands, North-West University, South Africa, National Institute of Public Health, Czech Republic, University of Jyväskylä, Finland, Amrita Institute of Medical Sciences, India, All India Institute of Medical Sciences, India, African Population and Health Research Center, Kenya, Ministerio de Salud Pública, Cuba, Sahlgrenska Academy, Sweden, Endocrinology and Metabolism Research Center, Iran, Food and Agriculture Organization, Italy, National University of Singapore, Singapore, Tampere University Hospital, Finland, Universiti Putra Malaysia, Malaysia, University of Cape Town, South Africa, West Virginia University, United States, Oswaldo Cruz Foundation Rene Rachou Research Institute, Brazil, National Taiwan University, Taiwan, University of Chinese Academy of Sciences, China, University Medicine Greifswald, Germany, Consejería de Sanidad Junta de Castilla y León, Spain, Universidade do Porto, Portugal, University of Uppsala, Sweden, Universidade Federal de Ouro Preto, Brazil, The Jikei University School of Medicine, Japan, National Research Council, Italy, Baker IDI Heart and Diabetes Institute, Australia, Hospital Israelita Albert Einstein, Brazil, Institute of Internal and Preventive Medicine, Russian Federation, Harokopio University, Greece, University of Otago, New Zealand, University of Padova, Italy, Emory University, United States, UiT The Arctic University of Norway, Norway, Cape Peninsula University of Technology, South Africa, Gorgas Memorial Institute of Health Studies, Panama, Brown University, United States, University of Edinburgh, United Kingdom, University College Dublin, Ireland, Penang Medical College, Malaysia, Institut National de la Santé et de la Recherche Médicale, France, Ain Shams University, Egypt, Hypertension Research Center, Iran, University of Pécs, Hungary, University of Limpopo, South Africa, Universidad de Zaragoza, Spain, RCSI Dublin, Ireland, International Institute of Molecular and Cell Biology, Poland, Ahvaz Jundishapur University of Medical Sciences, Iran, Gorgas Memorial Institute of Public Health, Panama, University of Brescia, Italy, Ulm University, Germany, Institute of Public Health, Malaysia, Kobe University, Japan, Suraj Eye Institute, India, INSERM, France, The University of Pharmacy and Medicine of Ho Chi Minh City, Viet Nam, Hanoi Medical University, Viet Nam, Universidad Centro-Occidental Lisandro Alvarado, Venezuela, Heartfile, Pakistan, Eastern Mediterranean Public Health Network, Jordan, Aarhus University, Denmark, Kwame Nkrumah University of Science and Technology, Ghana, Institute for Social and Preventive Medicine, Switzerland, University of Coimbra, Portugal, Cancer Prevention and Research Institute, Italy, University of Bari, Italy, Zayed University, United Arab Emirates, University Medical Center Utrecht, Netherlands, Public Health Agency of Canada, Canada, Heart Institute, Brazil, National Institute of Hygiene, Epidemiology and Microbiology, Cuba, Vietnam National Heart Institute, Viet Nam, Federal Ministry of Health, Bosnia and Herzegovina, Cardiovascular Prevention Centre Udine, Italy, University of New South Wales, Australia, Public Health Agency of Catalonia, Spain, University of Split, Croatia, Alborz University of Medical Sciences, Iran, Turku University Hospital, Finland, Julius Centre University of Malaya, Malaysia, University of Valencia, Spain, University of the Philippines, Philippines, Minas Gerais State Secretariat for Health, Brazil, Health Center San Agustín, Spain, PharmAccess Foundation, Netherlands, Canarian Health Service, Spain, Universidad Industrial de Santander, Colombia, Instituto Nacional de Salud Pública, Mexico, University of Madeira, Portugal, Sitaram Bhartia Institute of Science and Research, India, Marmara University, Turkey, University of Helsinki, Finland, National Institute of Health, Peru, Catalan Department of Health, Spain, Universidade de Lisboa, Portugal, University of Sao Paulo Clinics Hospital, Brazil, South Karelia Social and Health Care District, Finland, Robert Koch Institut, Germany, Isfahan Cardiovascular Research Center, Iran, Research and Education Institute of Child Health, Cyprus, Hospital Italiano de Buenos Aires, Argentina, Lagos State University College of Medicine, Nigeria, Digestive Diseases Research Institute, Iran, The University of Tokyo, Japan, St Vincent's Hospital, Australia, Lund University, Sweden, University of Copenhagen, Denmark, Institut Régional de Santé Publique, Benin, University of Bordeaux, France, University of Leuven, Belgium, Heart Foundation, Australia, Bonn University, Germany, Sotiria Hospital, Greece, National Institute of Public Health-National Institute of Hygiene, Poland, Fu Jen Catholic University, Taiwan, Ministry of Health, Jordan, IB-SALUT Area de Salut de Menorca, Spain, Institut de Recherche pour le Développement, France, Harvard T H Chan School of Public Health, United States, Hellenic Health Foundation, Greece, Government Medical College, India, Sefako Makgatho Health Science University, South Africa, Dasman Diabetes Institute, Kuwait, Ministry of Health, New Zealand, University of Tampere Tays Eye Center, Finland, Centro di Prevenzione Cardiovascolare Udine, Italy, Universidade Federal de Minas Gerais, Brazil, Finnish Institute of Occupational Health, Finland, Universidad Miguel Hernandez, Spain, Centre for Research in Environmental Epidemiology, Spain, University of the Witwatersrand, South Africa, University of Strasbourg, France, University College Cork, Ireland, Institute for Medical Research, Malaysia, Xinjiang Medical University, China, Beijing Tongren Hospital, China, St George's, University of London, United Kingdom, Medical University of Vienna, Austria, Institute of Food and Nutrition Development of Ministry of Agriculture, China, Children's Hospital of Fudan University, China, Chinese Center for Disease Control and Prevention, China, University of Cyprus, Cyprus, Ministry of Health, Malaysia, and Inner Mongolia Medical University, China

Abstract

Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings We pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. In 2015, central and eastern Europe, sub-Saharan Africa, and south Asia had the highest blood pressure levels. Prevalence of raised blood pressure decreased in high-income and some middle-income countries; it remained unchanged elsewhere. The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries. The global increase in the number of adults with raised blood pressure is a net effect of increase due to population growth and ageing, and decrease due to declining age-specific prevalence. Interpretation During the past four decades, the highest worldwide blood pressure levels have shifted from high-income countries to low-income countries in south Asia and sub-Saharan Africa due to opposite trends, while blood pressure has been persistently high in central and eastern Europe. Funding Wellcome Trust. © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license

Published
2017

30. Towards Oxide Electronics: a Roadmap

Author

Gertjan Koster, F. Miletto Granozio, Mark Huijben, Regina Dittmann, R. Tamayo, Ignasi Fina, Guus Rijnders, Mariona Coll, Lena F. Kourkoutis, Vincent Garcia, Rudolf Gross, M. Lira-Cantu, Albert Calleja, Pablo Sanchis, Thomas Mikolajick, J. van den Brink, Minh D. Nguyen, Gervasi Herranz, Mario Cuoco, Kyle Shen, Marco Fanciulli, Alexei Kalaboukhov, Elvira Fortunato, Kazuhiro Hono, Anne Siemon, Josep Fontcuberta, Simone Sanna, Brahim Dkhil, David J. Keeble, Hans Boschker, Evert Pieter Houwman, Judith L. MacManus-Driscoll, Matthias Althammer, Julie Grollier, Mari Napari, I. El Baggari, Manuel Bibes, Sz. Fujita, Jochen Mannhart, Jeremy Levy, Claes-Göran Granqvist, Hiroaki Sukegawa, Rodrigo Martins, M. Spreitzer, Gunnar A. Niklasson, Guanglei Cheng, Shrabani Panigrahi, Carlos Frontera, Nini Pryds, Sebastian T. B. Goennenwein, Uwe Schroeder, Florencio Sánchez, Stephan Menzel, A. Hagfeldt, Charles Paillard, Darrell G. Schlom, MARine Biodiversity Exploitation and Conservation (UMR MARBEC), Institut de Recherche pour le Développement (IRD)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Institut de Ciencia de materials de barcelone, walther-Meribner Institut, Bayerische Akademie der Wissenschaften (BADW), Unité mixte de physique CNRS/Thalès (UMP CNRS/THALES), THALES-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for Solid State Research, Max-Planck-Gesellschaft, Oxolutia S.I., Laboratoire Structures, Propriétés et Modélisation des solides (SPMS), CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Cornell University, Laboratorio Nazionale MDM CNR-INFM, CENIMAT/I3N, Departemento de Ciencia dos Materiais-Faculdade de Ciências e Tecnologia (FCT NOVA), Universidade Nova de Lisboa (NOVA)-Universidade Nova de Lisboa (NOVA), Centre de pharmacologie et innovation dans le diabète (CPID), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Photomolecular Science (LSPM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Institut de Ciència de Materials de Barcelona (ICMAB), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), University of Tsukuba, Institute for Nanotechnology (MESA+), University of Twente [Netherlands], Department of Microtechnology and Nanoscience (Chalmers University of Tehcnology) (MC2), Pittsburgh Quantum Institute, NaMLab gGmbH, Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, SE-75121 Uppsala, Sweden, Laboratoire des Sciences de l'Environnement Marin (LEMAR) (LEMAR), Centre National de la Recherche Scientifique (CNRS)-Université de Brest (UBO)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut Universitaire Européen de la Mer (IUEM), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université de Brest (UBO)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université de Brest (UBO)-Institut de Recherche pour le Développement (IRD), Propriétés Optiques des Matériaux et Applications (POMA), Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Institut de Veille Sanitaire [Paris] (INVS), Department of Materials Science and Engineering, Cornell University, USA, Institut fur Werkstoffe der Electrotechnick IWE2, Department of Energy Conversion and Storage, Technical University of Denmark [Lyngby] (DTU), Netherlands Organization for Scientific Research, National Science Foundation (US), Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Slovenian Research Agency, Engineering and Physical Sciences Research Council (UK), Air Force Office of Scientific Research (US), German Research Foundation, European Cooperation in Science and Technology, European Research Council, European Commission, Agence Nationale de la Recherche (France), Free State of Saxony, Office of Naval Research (US), Council for Science, Technology and Innovation (Japan), Fundación Repsol, Dirección General de Investigación Científica y Técnica, DGICT (España), Fundação para a Ciência e a Tecnologia (Portugal), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Unité mixte de physique CNRS/Thales (UMPhy CNRS/THALES), THALES [France]-Centre National de la Recherche Scientifique (CNRS), CAS Key Laboratory of Microscale Magnetic Resonance and Department of modern Physics, University of Electronic Science and Technology of China [Chengdu] (UESTC), Department of Physics and Astronomy [Pittsburgh], University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), Peter Grünberg Institut, Peter Grünberg Institut (PGI), Institut de Chimie du CNRS (INC)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Cornell University [New York], Laboratorio MDM (IMM-CNR), Consiglio Nazionale delle Ricerche [Roma] (CNR), Departemento de Ciencia dos Materiais, Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Faculdade de Ciências e Tecnologia = School of Science & Technology (FCT NOVA), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), CEMOT/UNINOVA, National Institute of Polar Research [Tokyo] (NiPR), Institut fur Festkorperphysik, Technische universitat Dresden, Center for transport and devices of Emergent materials, Technische Universitat Dresden, Departement of engineering sciences, the Angstrom Laboratory, Uppsala University, Physics department, Technische universitat munchen, Nanosystems Initiative Munich (NIM), Ludwig-Maximilians-Universität München (LMU), Université de Tsukuba = University of Tsukuba, University of Twente, Department of Microtechnology and Nanoscience (MC2), Chalmers University of Technology [Gothenburg, Sweden], Carnegie Laboratory of Physics, SUPA, school of science and engineering, School of Applied and Engineering physics [Ithaca] (AEP Cornell), Catalan Institute of Nanoscience and Nanotechnology (ICN2), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Barcelona Institute of Science and Technology (BIST), Departement of materials science and metallurgy, University of Cambridge, Dipartimento di Scienza dei Materiali = Department of Materials Science [Milano-Bicocca], Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), MDM Laboratory, IMM-CNR, University of Arkansas [Fayetteville], Universidad CEU Cardenal Herrera, Nanophotonics Technology Center, Universitat Politècnica de València (UPV), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Laboratory of Atomic and Solid State Physics [Ithaca] (LASSP), Departement of material science and engineering, Corell university, University of Copenhagen = Københavns Universitet (UCPH), Vinée-Jacquin, Christine, University of Electronic Science and Technology of China (UESTC), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Department of energy strorage and conversion, Technical university of Denmark, University of Copenhagen = Københavns Universitet (KU), Inorganic Materials Science, Coll, M, Fontcuberta, J, Althammer, M, Bibes, M, Boschker, H, Calleja, A, Cheng, G, Cuoco, M, Dittmann, R, Dkhil, B, El Baggari, I, Fanciulli, M, Fina, I, Fortunato, E, Frontera, C, Fujita, S, Garcia, V, Goennenwein, S, Granqvist, C, Grollier, J, Gross, R, Hagfeldt, A, Herranz, G, Hono, K, Houwman, E, Huijben, M, Kalaboukhov, A, Keeble, D, Koster, G, Kourkoutis, L, Levy, J, Lira-Cantu, M, MacManus-Driscoll, J, Mannhart, J, Martins, R, Menzel, S, Mikolajick, T, Napari, M, Nguyen, M, Niklasson, G, Paillard, C, Panigrahi, S, Rijnders, G, Sanchez, F, Sanchis, P, Sanna, S, Schlom, D, Schroeder, U, Shen, K, Siemon, A, Spreitzer, M, Sukegawa, H, Tamayo, R, van den Brink, J, Pryds, N, and Granozio, F

Subjects
Perovskite solar-cells, Ferroelectrics tunner-junctions, Engineering, X-ray-diffraction, Materialkemi, General Physics and Astronomy, 02 engineering and technology, Hole-transport layer, 7. Clean energy, 01 natural sciences, Nanoelectronics, Logic and memory devices, High-k dielectrics, Materials Chemistry, Energy transformation, Transparent conducting oxides, Zirconate-titanate films, ComputingMilieux_MISCELLANEOUS, doped zinc-oxide, hole-transport layer, x-ray-diffraction, Atomic layer deposition, Settore FIS/01 - Fisica Sperimentale, Oxides, Surfaces and Interfaces, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Periodic table, [PHYS.COND.CM-MS] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], ddc, Surfaces, Coatings and Films, Nanoelectronics, Computer data storage, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], ddc:660, 0210 nano-technology, ferroelectric tunnel-junctions, shockley-queisser limit, 010402 general chemistry, zirconate-titanate films, free piezoelectric ceramics, Deliverable, Free piezoelectric ceramics, Power electronics, Oxide electronics, ddc:530, Electronics, business.industry, Technological change, General Chemistry, Engineering physics, perovskite solar-cells, 0104 chemical sciences, Information and Communications Technology, atomic layer deposition, Doped zinc-oxide, transparent conducting oxides, business, Shockley-Queisser limit
Abstract

At the end of a rush lasting over half a century, in which CMOS technology has been experiencing a constant and breathtaking increase of device speed and density, Moore’s law is approaching the insurmountable barrier given by the ultimate atomic nature of matter. A major challenge for 21st century scientists is finding novel strategies, concepts and materials for replacing silicon-based CMOS semiconductor technologies and guaranteeing a continued and steady technological progress in next decades. Among the materials classes candidate to contribute to this momentous challenge, oxide films and heterostructures are a particularly appealing hunting ground. The vastity, intended in pure chemical terms, of this class of compounds, the complexity of their correlated behaviour, and the wealth of functional properties they display, has already made these systems the subject of choice, worldwide, of a strongly networked, dynamic and interdisciplinary research community. Oxide science and technology has been the target of a wide four-year project, named Towards Oxide-Based Electronics (TO-BE), that has been recently running in Europe and has involved as participants several hundred scientists from 29 EU countries. In this review and perspective paper, published as a final deliverable of the TO-BE Action, the opportunities of oxides as future electronic materials for Information and Communication Technologies ICT and Energy are discussed. The paper is organized as a set of contributions, all selected and ordered as individual building blocks of a wider general scheme. After a brief preface by the editors and an introductory contribution, two sections follow. The first is mainly devoted to providing a perspective on the latest theoretical and experimental methods that are employed to investigate oxides and to produce oxide-based films, heterostructures and devices. In the second, all contributions are dedicated to different specific fields of applications of oxide thin films and heterostructures, in sectors as data storage and computing, optics and plasmonics, magnonics, energy conversion and harvesting, and power electronics., The authors acknowledge financial support from the Netherlands Organization for Scientific Research (NWO). We acknowledge fruitful interactions with our many collaborators in the realm of artificial quantum materials, especially the groups of J.C. Séamus Davis, Craig J. Fennie, Eun-Ah Kim, Lena F. Kourkoutis, and David A. Muller. This work was supported by the National Science Foundation (Platform for the Accelerated Realization, Analysis, and Discovery of Interface Materials (PARADIM)) under Cooperative Agreement No. DMR-1539918. Financial support from the Spanish Ministry of Economy and Competitiveness (SEV-2015-0496, MAT2014-56063-C2-1-R, and MAT2017-85232-R), from Generalitat de Catalunya (2014 SGR 734), and from Slovenian Research Agency (P2-0091 and J2-6759) is acknowledged. The authors acknowledge funding from the EPSRC grant EP/ P027032/1. Prof. O. Nilsen is acknowledged for valuable discussions on the current status of ALD perovskites. Author thanks fruitful discussions with Dr. J. Santiso. Financial support from the Spanish Ministry of Economy and Competitiveness through the ''Severo Ochoa" Programme for Centres of Excellence in R&D (SEV-2015-0496), and projects MAT2015-71664-R and MAT2015- 67593-P is acknowledged. This work was supported by PARADIM, a National Science Foundation Materials Innovation Platform (Grant DMR-1539918), and by the Air Force Office of Scientific Research (Award number FA 9550-16-1-0305). Funding from the DFG (German Science Foundation) within the collaborative research center SFB 917 'Nanoswitches' and the W2/ W3 program of the Helmholtz association is gratefully acknowledged. We furthermore acknowledge funding by the ToBE CoST action (MP1308). We acknowledge financial support from the ERC Consolidator grant ‘‘MINT” (contract number n° 615759) and the ANR project ‘‘FERROMON”. This publication has received funding from the European Union’s Horizon 2020 research innovation programme under grant agreement 732642 (ULPEC project). This work is supported by a public grant overseen by the French National Research Agency (ANR) as part of the ‘‘Investissements d’Avenir” program (Labex NanoSaclay, reference: ANR-10-LABX-0035). This work was supported in part by the EFRE fund of the European Commission, by the Free State of Saxony (Germany), and by funding of the Deutsche Forschungsgemeinschaft (DFG project: Inferox). This work was supported in parts by the Deutsche Forschungsge-meinschaft (DFG) under Grant SFB 917 ''Nanoswitches" and the COST Action MP1308 ''TO-BE (Towards Oxide-Based Electronics)". This publication has received funding from the European Union’s Horizon 2020 research innovation programme under grant agree-ment 732642 (ULPEC project). We thank M. Belmoubarik and J. Uzuhashi for their technical assistance for Fig. 36. We acknowledge support from the ImPACT Program of Council for Science, Technology and Innovation, Japan. Gervasi Herranz acknowledges financial support from MAT2014-56063-C2-1-R and Severo Ochoa SEV-2015-0496 Projects, and the Generalitat de Catalunya (2014 SGR 734Project). Pablo Sanchis acknowledges financial support from TEC2016-76849 and FP7-ICT-2013-11-619456 SITOGA. We thank the financial support from the SNSF NRP70 ‘‘Energy Turnaround” and GRAPHENE project supported by the European Commission Seventh Framework Programme under contract 604391 is gratefully acknowledged. To the Spanish MINECO through the Severo Ochoa Centers of Excellence Program under Grant SEV-2013-0295; for the grant ENE2016-79282-C5-2-R and the OrgEnergy Excelence NetworkCTQ2016-81911-REDT. To the Agència de Gestió d’Ajuts Universitaris i de Recerca for the support to the consolidated Catalonia research group 2014SGR-1212 and the Xarxa de Referència en Materials Avançats per a l’Energia (Xarmae). To the CERCA Pro-gramme/Generalitat de Catalunya and to the European COST Action StableNextSol project MP1307. The authors would like to acknowledge the financial support from ACCIO-Generalitat de Catalunya and the European Union for the 3D-PHOTOXIDES ERA-NET MANUNET II and from IV Fondo de Emprendedores of Fundación Repsol for the SOLAR OXIDES project. The authors would also thank Mr. Andrés Gómez from Institut de Ciència de Materials de Barcelona (ICMAB) for the pc-AFM measure-ments and Mr. Alex Hernández from Institut de Recerca en Energia de Catalunya (IREC) for the sputtering and valuable guidance. We would like to acknowledge the financial support granted by the Spanish Government [Projects MAT2014-56063-C2-1-R, MAT2015-73839-JIN, MAT2014-51778-C2-1-R and MAT2014-57960-C3-1-R, and associated FEDER], I.F. acknowledges Ramon y Cajal contract RYC-2017-22531, the Generalitat de Catalunya (2014-SGR-734). ICMAB-CSIC authors acknowledge financial support from the Spanish Ministry of Economy and Competitiveness, through the ‘‘Severo Ochoa” Program for Centers of Excellence in R&D (SEV-2015-0496). C.P. and B.D. acknowledge a public grant overseen by the French National Research Agency (ANR) as part of the ‘‘Investissements d’Avenir” program (Grant No. ANR-10-LABX-0035, Labex NanoSaclay). The authors would like to acknowledge L. Pereira and P. Bar-quinha for fruitful discussions during the manuscript preparation. We acknowledge the funding from Portuguese Foundation for Science and Technology, Reference UID/CTM/50025/2013 and FEDER funds through the COMPETE 2020 Programme under the project number POCI-01-0145-FEDER-007688. Part of this work is partially financed from European Community H2020 program under grant agreements No. 665046 (project Symbiotic) and No. 644631 (project Roll-Out). Several of the recent advances in electrochromic and ther-mochromic materials, reported above, were reached with financial support received from the European Research Council under the European Community’s Seventh Framework Program (FP2007– 2013)/ERC Grant Agreement No. 267234 (‘‘GRINDOOR”).

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31. Optimism in inclusion body myositis: a double-blind randomised controlled phase III trial investigating the effect of sirolimus on disease progression in patients with IBM as measured by the IBM Functional Rating Scale.

Author

Badrising UA, Henderson R, Reddel S, Corbett A, Liang C, Reardon K, Ghaoui R, Bulsara M, Brady S, Brusch A, Chan D, Coudert JD, Fairchild T, Jain G, Kiernan MC, Leonard D, Lloyd T, Schmidt J, McDermott MP, Sanders L, Lowe C, van der Kooi AJ, Weihl C, Mohassel P, Simpson M, Carroll A, Cooper I, Beer K, Hiscock K, Walters S, Panicker A, Doverty A, Heim A, van Heur-Neuman M, Benveniste O, Dimachkie MM, and Needham M

Subjects
Humans, Double-Blind Method, Treatment Outcome, Randomized Controlled Trials as Topic, Clinical Trials, Phase III as Topic, Immunosuppressive Agents therapeutic use, Immunosuppressive Agents adverse effects, Male, Female, Clinical Trials, Phase II as Topic, Adult, Middle Aged, Myositis, Inclusion Body drug therapy, Myositis, Inclusion Body physiopathology, Disease Progression, Sirolimus therapeutic use
Abstract

Objectives: Inclusion body myositis (IBM) is a complex inflammatory muscle disease in adults over 40, with histological features of autoinflammation, cell stress and autophagic abnormalities, and marked clinically by relentless progression with no effective disease-modifying therapy. Sirolimus (rapamycin) may help maintain function by inhibiting T effector cells, preserving T regulatory cells, inducing autophagy, and improving mitochondrial function. This international trial follows a phase II pilot study., Methods: This phase IIb/III double-blind, randomised, controlled trial (RCT) of sirolimus involves 140 IBM patients randomly assigned with equal allocation to sirolimus (2 mg) or matching placebo. This RCT aims to assess the efficacy of sirolimus compared to placebo in slowing or stabilising IBM progression, as measured by the mean change in patient function using the IBM Functional Rating Scale (IBM-FRS) from Baseline to Week 84. Secondary outcomes will evaluate efficacy and safety to inform future clinical trial design., Results: Ethical approval has been granted in Australia (St Vincent's Hospital Melbourne HREC-D 311/20) and the USA (University of Kansas Medical Center Human Research Protection Program FWA no. 00003411), with European approval pending. The protocol is version 3.0 (02-Dec-2022)., Trial Registration: ANZCTR: ACTRN12620001226998p, ClinicalTrials.gov: NCT04789070, UTN: U1111-1258-1354, and EU CT 2024-514575-17-00., Conclusions: This phase IIb/III trial builds on prior findings to assess sirolimus's potential in slowing or halting IBM progression, preserving patient function and independence, and advancing IBM therapeutic strategies and trial design.

Published
2025
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32. Sprouting sideways: queer temporalities and kinship in donor conception.

Author

Andreassen R, Newton G, and Dahl U

Abstract

Temporal constructs are central to reproduction and kinship, as epitomised by the pervasive concept of the biological clock within public imaginaries. While queer scholarship has problematised linear models of kinship and reproductive temporality, the specific temporalities associated with donor-conceived families have received less scholarly attention, despite the increasing prevalence of these family structures. In this article, we explore the question: how does donor conception reconfigure temporal logics. More specifically, we ask how does donor conception challenge (hetero)normative temporalities and kinship organisations. We examine donor conception through narratives of the embodied and intimate experiences of key stakeholders in the form of clinical staff, parents and donor-conceived adults, across case studies conducted in Denmark, Sweden and Australia. Our analysis illuminates distinct temporal perspectives: for clinic staff, donors exist in a static present; for recipient parents, the donor's past is integrated into the present; and for donor-conceived adults, the donor is embedded within fragile futurities. We propose the concept of sideways temporalities to capture the queering of temporal logics in donor conception, characterised by non-normative scale (e.g. extensive sibling networks) and velocity (e.g. immediate matching via DNA testing).

Published
2025
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33. Diarrhoea of unknown cause: medical treatment in a stepwise manner Management of Idiopathic Diarrhoea Based on Experience of Step-Up Medical Treatment .

Author

Jansson-Rehnberg AS, Drewes AM, Sponheim J, Borgfelt C, Münch A, Graf W, Simrén M, Lindberg G, and Hellström PM

Subjects
Humans, Loperamide therapeutic use, Octreotide therapeutic use, Clonidine therapeutic use, Clonidine analogs & derivatives, Diarrhea drug therapy, Diarrhea etiology, Antidiarrheals therapeutic use
Abstract

The basic principle for the treatment of idiopathic diarrhoea (functional diarrhoea K59.1) is to delay transit through the gut in order to promote the absorption of electrolytes and water. Under mild conditions, bulking agents may suffice. With increasing severity, antidiarrhoeal pharmaceuticals may be added in a stepwise manner. In diarrhoea of unknown aetiology, peripherally-acting opioid receptor agonists, such as loperamide, are first-line treatment and forms the pharmaceutical basis of antidiarrheal treatment. As second-line treatment opium drops have an approved indication for severe diarrhoea when other treatment options fail. Beyond this, various treatment options are built on experience with more advanced treatments using clonidine, octreotide, as well as GLP-1 and GLP-2 analogs which require specialist knowledge the field.

Published
2024
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34. The Association Between Body Mass Index and Death Following Elective Endovascular and Open Repair of Abdominal Aortic Aneurysms in the Vascular Quality Initiative.

Author

D'Oria M, Scali S, Neal D, DeMartino R, Mani K, Budtz-Lilly J, Lepidi S, and Stone DH

Subjects
Humans, Body Mass Index, Risk Factors, Treatment Outcome, Retrospective Studies, Endovascular Procedures adverse effects, Aortic Aneurysm, Abdominal diagnostic imaging, Aortic Aneurysm, Abdominal surgery, Aortic Aneurysm, Abdominal complications, Blood Vessel Prosthesis Implantation adverse effects
Abstract

Objective: The effect of body mass index (BMI) on post-operative outcomes after abdominal aortic aneurysm (AAA) repair remains poorly defined. The association between BMI and death following elective endovascular aneurysm repair (EVAR) and open aneurysm repair (OAR) of AAA in a large national quality registry is investigated., Methods: All elective AAA repairs within the Society for Vascular Surgery Vascular Quality Initiative (VQI; 2010 to September 2021) were reviewed (EVAR, n = 53 426; OAR, n = 9 479). All analyses were conducted separately for EVAR and OAR patients. The primary end points were 30 day mortality and five year survival rates. Study cohorts were divided into World Health Organisation BMI categories (C1 < 18.5, C2 18.5 ≤ BMI < 25, C3 25 ≤ BMI < 30, C4, 30 ≤ BMI < 35, C5 35 ≤ BMI < 40, C6 ≥ 40). BMI was examined as both a categorical and continuous variable. Logistic and Cox proportional hazards regression were used for risk adjustment., Results: Among EVAR patients, BMI distribution was C1, 1 216 (2%); C2, 14 687 (28%); C3, 20 516 (38%); C4, 11 352 (21%); C5, 3 947 (7%); C6, 1 708 (3%). Class 1, 2, and 6 BMI patients experienced an increased 30 day mortality rate (C1 2.6%; C2 1.3%; C6 1.4% vs. C3 - 5 0.7%; p < .001) and C1 and C2 had correspondingly inferior long term survival (five years: C1 69 ± 3%; C2 79 ± 1% vs. C3 - 6 86 - 88 ± 2%; log rank p < .001). These survival disparities persisted after risk adjustment for multiple confounders. In the OAR cohort, BMI distribution was C1, 280 (3%); C2, 2 862 (30%); C3, 3 587 (38%); C4, 1 940 (21%); C5, 581 (6%); C6, 229 (2%). Crude 30 day mortality rates were increased for both the lowest and highest BMI patients (C1 12%, C6 7% vs. C2 - 5 3 - 4%; p < .001); these differences also persisted in long term survival (five years: C1 71 ± 6%, C6 82 ± 6% vs. C2 - 6 85 - 88 ± 3%; log rank p < .001). In risk adjusted analysis, both low and high BMI OAR patients had an increased 30 day and long term mortality rate., Conclusion: Within the VQI, both the extreme low (< 18.5) and high (≥ 40) BMI groups experienced an increased 30 day mortality rate after both elective EVAR and OAR. By comparison, while the lowest BMI cohort was significantly associated with decreased long term survival after both procedures, the highest BMI group only experienced reduced long term survival after OAR. Based upon this large real world registry analysis of elective AAA repairs, differential metabolic signatures exist within extreme BMI categories, which may inform peri-operative risk stratification and clinical decision making., (Copyright © 2023 European Society for Vascular Surgery. Published by Elsevier B.V. All rights reserved.)

Published
2023
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35. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane.

Author

Enlund M, Berglund A, Enlund A, Lundberg J, Wärnberg F, Wang DX, Ekman A, Ahlstrand R, Flisberg P, Hedlund L, Östlund I, and Bergkvist L

Abstract

Background: Anaesthesia may impact long-term cancer survival. In the Cancer and Anaesthesia study, we hypothesised that the hypnotic drug propofol will have an advantage of at least five percentage points in five-year survival over the inhalational anaesthetic sevoflurane for breast cancer surgery., Methods: From 2118 eligible breast cancer patients scheduled for primary curable, invasive breast cancer surgery, 1764 were recruited after ethical approval and individual informed consent to this open label, single-blind, randomised trial at four county- and three university hospitals in Sweden and one Chinese university hospital. Of surveyed patients, 354 were excluded, mainly due to refusal to participate. Patients were randomised by computer at the monitoring organisation to general anaesthesia maintenance with either intravenous propofol or inhaled sevoflurane in a 1:1 ratio in permuted blocks. Data related to anaesthesia, surgery, oncology, and demographics were registered. The primary endpoint was five-year overall survival. Data are presented as Kaplan-Meier survival curves and Hazard Ratios based on Cox univariable regression analyses by both intention-to-treat and per-protocol. EudraCT, 2013-002380-25 and ClinicalTrials.gov, NCT01975064., Findings: Of 1764 patients, included from December 3, 2013, to September 29, 2017, 1670 remained for analysis. The numbers who survived at least five years were 773/841 (91.9% (95% CI 90.1-93.8)) in the propofol group and 764/829 (92.2% (90.3-94.0)) in the sevoflurane group, (HR 1.03 (0.73-1.44); P = 0.875); the corresponding results in the per-protocol-analysis were: 733/798 (91.9% (90.0-93.8)) and 653/710 (92.0% (90.0-94.0)) (HR = 1.01 (0.71-1.44); P = 0.955). Survival after a median follow-up of 76.7 months did not indicate any difference between the groups (HR 0.97, 0.72-1.29; P = 0.829, log rank test)., Interpretation: No difference in overall survival was found between general anaesthesia with propofol or sevoflurane for breast cancer surgery., Funding: Swedish Research Council; Uppsala-Örebro Regional Research Council; Västmanland Regional Research Fund; Västmanland Cancer Foundation; Stig and Ragna Gohrton Foundation; Birgit and Henry Knutsson Foundation., Competing Interests: Dr M. Enlund has received consulting fees from Nimbelle AB, honoraria for lectures from Mälardalen University, and is on the board of the ENCORE trial. Dr L. Bergkvist has received honoraria for arranging a course in cooperation with AstraZeneca. Dr J. Lundberg served as Editor on the Editorial Board of Acta Anaesthesiologica Scandinavica until February 2023. All other authors have nothing to declare., (© 2023 The Author(s).)

Published
2023
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36. Mental-health profiling with person-centred analysis: A study of adolescents in Sweden.

Author

Eriksson C and Stattin H

Subjects
Child, Humans, Adolescent, Sweden epidemiology, Surveys and Questionnaires, Poverty, Psychophysiologic Disorders epidemiology, Psychophysiologic Disorders psychology, Mental Health, Self Concept
Abstract

Background: Studies that have examined time trends in adolescents' mental health have frequently been based on analyses of adolescents' psychosomatic symptoms. Adolescents' reports of psychosomatic complaints need to be seen in the light of their overall evaluations of their health. The objectives of this study were to apply a person-centred approach to identifying adolescents' mental-health profiles based on evaluations of their overall health and psychosomatic complaints. The relationships between these mental-health profiles and indicators of positive mental health and psychological and social-adjustment problems are examined., Methods: A dual-factor approach was used for nationally representative adolescent samples and examined adolescents' self-rated psychosomatic complaints and perceived overall health simultaneously. Cluster analyses of data from the Swedish Health Behaviour in School-aged Children (HBSC) 2017/18 survey, including 3222 children aged 11, 13 and 15, were used to identify mental-health profiles., Results: Four mental-health profiles were identified by cluster analyses in all age groups. The profiles showed good construct validity in relation to mental well-being, life satisfaction and self-esteem. The poorest psychological adjustment was found among the adolescents with high levels of psychosomatic symptoms together with low levels of perceived overall health. Adolescents with high levels of psychosomatic symptoms only or with low levels of overall health only showed considerably better psychological adjustment., Conclusions: Cluster analyses identified distinct, valid and consistent mental-health profiles based on differing levels of perceived health and psychosomatic complaints. The dual-factor model in population health research may increase our potential to understand the mental health of adolescents better.

Published
2023
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37. Reply to: "Re. Pre-Operative Moderate to Severe Chronic Kidney Disease is Associated with Worse Short and Midterm Outcomes in Patients Undergoing Fenestrated Branched Endovascular Aortic Repair".

Author

D'Oria M and Mani K

Subjects
Blood Vessel Prosthesis, Humans, Prosthesis Design, Risk Factors, Treatment Outcome, Aortic Aneurysm, Thoracic surgery, Blood Vessel Prosthesis Implantation adverse effects, Endovascular Procedures adverse effects, Renal Insufficiency, Chronic complications
Published
2022
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38. Influence of the age at diagnosis in the disease expression of primary Sjögren syndrome. Analysis of 12,753 patients from the Sjögren Big Data Consortium.

Author

Retamozo S, Acar-Denizli N, Horváth IF, Ng WF, Rasmussen A, Dong X, Li X, Baldini C, Olsson P, Priori R, Seror R, Gottenberg JE, Kruize AA, Hernandez-Molina G, Vissink A, Sandhya P, Armagan B, Quartuccio L, Sebastian A, Praprotnik S, Bartoloni E, Kwok SK, Kvarnstrom M, Rischmueller M, Soláns-Laqué R, Sene D, Pasoto SG, Suzuki Y, Isenberg DA, Valim V, Nordmark G, Nakamura H, Fernandes Moça Trevisani V, Hofauer B, Sisó-Almirall A, Giacomelli R, Devauchelle-Pensec V, Bombardieri M, Atzeni F, Hammenfors D, Maure B, Carsons SE, Gheita T, Sánchez-Berná I, López-Dupla M, Morel J, Inanç N, Fonseca-Aizpuru E, Morcillo C, Vollenweider C, Melchor S, Vázquez M, Díaz-Cuiza E, Consani-Fernández S, de-Miguel-Campo B, Szántó A, Bombardieri S, Gattamelata A, Hinrichs A, Sánchez-Guerrero J, Danda D, Kilic L, De Vita S, Wiland P, Gerli R, Park SH, Wahren-Herlenius M, Bootsma H, Mariette X, Ramos-Casals M, and Brito-Zerón P

Subjects
Big Data, Humans, Sjogren's Syndrome diagnosis, Sjogren's Syndrome epidemiology
Abstract

Objectives: To analyse how the main components of the disease phenotype (sicca symptoms, diagnostic tests, immunological markers and systemic disease) can be driven by the age at diagnosis of primary Sjögren's syndrome (pSS)., Methods: By January 2021, the participant centres had included 12,753 patients from 25 countries that fulfilled the 2002/2016 classification criteria for pSS. The age at diagnosis was defined as the time when the attending physician confirmed fulfilment of the criteria. Patients were clustered according to age at diagnosis. 50 clusters with more than 100 observations (from 27 to 76 years) were used to study the influence of the age at diagnosis in the disease expression., Results: There was a consistent increase in the frequency of oral dryness according to the age at diagnosis, with a frequency of <90% in patients diagnosed at the youngest ages and >95% in those diagnosed at the oldest ages. The smooth curves that best fitted a linear model were the frequency of dry mouth (adjusted R2 0.87) and the frequency of abnormal oral tests (adjusted R2 0.72). Therefore, for each 1-year increase in the age at diagnosis, the frequency of dry mouth increased by 0.13%, and the frequency of abnormal oral diagnostic tests by 0.11%. There was a consistent year-by-year decrease in the frequency of all autoantibodies and immunological markers except for cryoglobulins. According to the linear models, for each 1-year increase in the age at diagnosis, the frequency of a positive result decreased by 0.57% (for anti-Ro antibodies), 0.47% (for RF) and 0.42% (for anti-La antibodies). The ESSDAI domains which showed a more consistent decrease were glandular and lymph node involvement (for each 1-year increase in the age at diagnosis, the frequency of activity decreased by 0.18%), and constitutional, cutaneous, and haematological involvements (the frequency decreased by 0.09% for each 1-year increase). In contrast, other domains showed an ascending pattern, especially pulmonary involvement (for each 1-year increase in the age at diagnosis, the frequency of activity increased by 0.22%), and peripheral nerve involvement (the frequency increased by 0.09% for each 1-year increase)., Conclusions: The influence of the age at diagnosis on the key phenotypic features of pSS is strong, and should be considered critical not only for designing a personalised diagnostic approach, but also to be carefully considered when analysing the results of diagnostic tests and immunological parameters, and when internal organ involvement is suspected at diagnosis.

Published
2021
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39. Key Characteristics of Cardiovascular Toxicants.

Author

Lind L, Araujo JA, Barchowsky A, Belcher S, Berridge BR, Chiamvimonvat N, Chiu WA, Cogliano VJ, Elmore S, Farraj AK, Gomes AV, McHale CM, Meyer-Tamaki KB, Posnack NG, Vargas HM, Yang X, Zeise L, Zhou C, and Smith MT

Subjects
Carcinogens, Hazardous Substances toxicity, Particulate Matter analysis, Air Pollutants analysis, Air Pollution analysis, Environmental Pollutants toxicity
Abstract

Background: The concept of chemical agents having properties that confer potential hazard called key characteristics (KCs) was first developed to identify carcinogenic hazards. Identification of KCs of cardiovascular (CV) toxicants could facilitate the systematic assessment of CV hazards and understanding of assay and data gaps associated with current approaches., Objectives: We sought to develop a consensus-based synthesis of scientific evidence on the KCs of chemical and nonchemical agents known to cause CV toxicity along with methods to measure them., Methods: An expert working group was convened to discuss mechanisms associated with CV toxicity., Results: The group identified 12 KCs of CV toxicants, defined as exogenous agents that adversely interfere with function of the CV system. The KCs were organized into those primarily affecting cardiac tissue (numbers 1-4 below), the vascular system (5-7), or both (8-12), as follows: 1) impairs regulation of cardiac excitability, 2) impairs cardiac contractility and relaxation, 3) induces cardiomyocyte injury and death, 4) induces proliferation of valve stroma, 5) impacts endothelial and vascular function, 6) alters hemostasis, 7) causes dyslipidemia, 8) impairs mitochondrial function, 9) modifies autonomic nervous system activity, 10) induces oxidative stress, 11) causes inflammation, and 12) alters hormone signaling., Discussion: These 12 KCs can be used to help identify pharmaceuticals and environmental pollutants as CV toxicants, as well as to better understand the mechanistic underpinnings of their toxicity. For example, evidence exists that fine particulate matter [PM ≤ 2.5 μ m in aerodynamic diameter ( PM 2.5 )] air pollution, arsenic, anthracycline drugs, and other exogenous chemicals possess one or more of the described KCs. In conclusion, the KCs could be used to identify potential CV toxicants and to define a set of test methods to evaluate CV toxicity in a more comprehensive and standardized manner than current approaches. https://doi.org/10.1289/EHP9321.

Published
2021
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40. Rheumatoid arthritis autoantibodies and their association with age and sex.

Author

Pertsinidou E, Manivel VA, Westerlind H, Klareskog L, Alfredsson L, Mathsson-Alm L, Hansson M, Saevarsdottir S, Askling J, and Rönnelid J

Subjects
Anti-Citrullinated Protein Antibodies, Epitopes, Female, Humans, Male, Peptides, Cyclic, Rheumatoid Factor, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid epidemiology, Autoantibodies
Abstract

Objectives: To examine the association between individual rheumatoid arthritis (RA) autoantibodies, sex and age at RA onset., Methods: Anti-CCP2, IgA-, IgG- and IgM-RF were analysed centrally in baseline sera from 1600 RA patients diagnosed within one year of RA symptom onset. Cut-offs for RF isotypes were determined at the 98th percentile based on RA-free controls, close to the 98.4% anti-CCP2 specificity., Results: Anti-CCP2 was found in 1020 patients (64%), IgA RF in 692 (43%), IgG RF in 529 (33%) and IgM RF in 916 (57%) of the patients. When assessed one by one, anti-CCP2 and IgM RF were both associated with lower age at RA diagnosis. When assessed in one joint model, the association to IgM RF weakened and a strong association between IgA RF and higher age at RA diagnosis appeared. IgA RF and IgG RF associated with male sex, and IgM RF with female sex, with no difference for anti-CCP2. When the model was adjusted for sex, the association between IgM RF and age disappeared, whereas the strong associations between IgA RF and high age and between anti-CCP2 and low age at diagnosis remained. Further adjustments for smoking, shared epitope and inclusion year did not change the outcome. Univariate analyses stratified on anti-CCP2 and IgA RF status confirmed the findings., Conclusions: Anti-CCP associate with low, and IgA RF with high age at RA onset. RFs and anti-CCP2 display opposing association with sex. These results underscore that studies on RA phenotypes in relation to autoantibodies should accommodate age and sex.

Published
2021
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41. The components of directional and disruptive selection in heterogeneous group-structured populations.

Author

Ohtsuki H, Rueffler C, Wakano JY, Parvinen K, and Lehmann L

Subjects
Alleles, Biological Evolution, Models, Genetic, Phenotype, Reproduction, Selection, Genetic
Abstract

We derive how directional and disruptive selection operate on scalar traits in a heterogeneous group-structured population for a general class of models. In particular, we assume that each group in the population can be in one of a finite number of states, where states can affect group size and/or other environmental variables, at a given time. Using up to second-order perturbation expansions of the invasion fitness of a mutant allele, we derive expressions for the directional and disruptive selection coefficients, which are sufficient to classify the singular strategies of adaptive dynamics. These expressions include first- and second-order perturbations of individual fitness (expected number of settled offspring produced by an individual, possibly including self through survival); the first-order perturbation of the stationary distribution of mutants (derived here explicitly for the first time); the first-order perturbation of pairwise relatedness; and reproductive values, pairwise and three-way relatedness, and stationary distribution of mutants, each evaluated under neutrality. We introduce the concept of individual k-fitness (defined as the expected number of settled offspring of an individual for which k-1 randomly chosen neighbors are lineage members) and show its usefulness for calculating relatedness and its perturbation. We then demonstrate that the directional and disruptive selection coefficients can be expressed in terms individual k-fitnesses with k=1,2,3 only. This representation has two important benefits. First, it allows for a significant reduction in the dimensions of the system of equations describing the mutant dynamics that needs to be solved to evaluate explicitly the two selection coefficients. Second, it leads to a biologically meaningful interpretation of their components. As an application of our methodology, we analyze directional and disruptive selection in a lottery model with either hard or soft selection and show that many previous results about selection in group-structured populations can be reproduced as special cases of our model., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Published
2020
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42. Pharmacologic treatment and SUDEP risk: A nationwide, population-based, case-control study.

Author

Sveinsson O, Andersson T, Mattsson P, Carlsson S, and Tomson T

Subjects
Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Pharmaceutical Preparations, Polypharmacy, Sweden epidemiology, Young Adult, Death, Sudden etiology, Drug-Related Side Effects and Adverse Reactions mortality, Epilepsy mortality, Registries statistics & numerical data
Abstract

Objective: We conducted a nationwide case-control study in Sweden to test the hypothesis that antiepileptic drugs (AEDs) mono- or polytherapy, adherence, antidepressants, neuroleptics, β-blockers, and statins are associated with sudden unexpected death in epilepsy (SUDEP) risk., Methods: Included were 255 SUDEP cases and 1,148 matched controls. Information on clinical factors and medications came from medical records and the National Patient and Prescription Registers. The association between SUDEP and medications was assessed by odds ratios (ORs) with 95% confidence intervals (CIs) adjusted for potential risk factors including type of epilepsy, living conditions, comorbidity, and frequency of generalized tonic-clonic seizures (GTCS)., Results: Polytherapy, especially taking 3 or more AEDs, was associated with a substantially reduced risk of SUDEP (OR 0.31, 95% CI 0.14-0.67). Combinations including lamotrigine (OR 0.55, 95% CI 0.31-0.97), valproic acid (OR 0.53, 95% CI 0.29-0.98), and levetiracetam (OR 0.49, 95% CI 0.27-0.90) were associated with reduced risk. No specific AED was associated with increased risk. Regarding monotherapy, although numbers were limited, the lowest SUDEP risk was seen in users of levetiracetam (0.10, 95% CI 0.02-0.61). Having nonadherence mentioned in the medical record was associated with an OR of 2.75 (95% CI 1.58-4.78). Statin use was associated with a reduced SUDEP risk (OR 0.34, 95% CI 0.11-0.99) but selective serotonin reuptake inhibitor use was not., Conclusion: These results provide support for the importance of medication adherence and intensified AED treatment for patients with poorly controlled GTCS in the effort to reduce SUDEP risk and suggest that comedication with statins may reduce risk., (Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)

Published
2020
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43. Physical function tests predict incident falls: A prospective study of 2969 men in the Swedish Osteoporotic Fractures in Men study.

Author

Cöster ME, Karlsson M, Ohlsson C, Mellström D, Lorentzon M, Ribom E, and Rosengren B

Subjects
Aged, Aged, 80 and over, Hand Strength physiology, Humans, Incidence, Male, Prospective Studies, Risk Factors, Surveys and Questionnaires, Sweden epidemiology, Walking physiology, Accidental Falls statistics & numerical data, Physical Functional Performance
Abstract

Aims: Falls are common in the elderly population, and fall-related injuries are a major health issue. We investigated the ability of simple physical tests to predict incident falls. Methods : The Swedish Osteoporotic Fractures in Men (MrOS) study includes 3014 population-based men aged 69-81 years at the start of the study. These men performed five different physical tests at baseline: right-hand grip strength, left-hand grip strength, timed stand test, 6 m walking test (time and steps) and narrow walking test. During the first study year, we asked participants to fill out questionnaires regarding falls 4, 8 and 12 months after baseline. A total of 2969 men completed at least one questionnaire and were included in this study. We used generalised estimating equations and logarithmic regression models to estimate odds ratios for fallers and recurrent fallers (more than one fall during the one-year examination period) in each quartile of men for each physical test. Results : The proportions of fallers and recurrent fallers were higher in the lowest quartile of the physical tests than in the other three quartiles combined for all physical tests. A reduction of one standard deviation in respective physical test resulted in a 13-21% higher risk of becoming a faller and a 13-31% higher risk of becoming a recurrent faller. : Low results on simple physical tests is a risk factor for incident falls in elderly Swedish men and may facilitate identification of high-risk individuals suitable for fall-intervention programs.Conclusions : Low results on simple physical tests is a risk factor for incident falls in elderly Swedish men and may facilitate identification of high-risk individuals suitable for fall-intervention programs.

Published
2020
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44. Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study.

Author

Heikkilä K, Pentti J, Madsen IEH, Lallukka T, Virtanen M, Alfredsson L, Bjorner J, Borritz M, Brunner E, Burr H, Ferrie JE, Knutsson A, Koskinen A, Leineweber C, Magnusson Hanson LL, Nielsen ML, Nyberg ST, Oksanen T, Pejtersen JH, Pietiläinen O, Rahkonen O, Rugulies R, Singh-Manoux A, Steptoe A, Suominen S, Theorell T, Vahtera J, Väänänen A, Westerlund H, and Kivimäki M

Subjects
Adult, Aged, Europe epidemiology, Female, Hospitalization, Humans, Male, Middle Aged, Occupational Stress diagnosis, Peripheral Arterial Disease diagnosis, Peripheral Arterial Disease therapy, Risk Assessment, Risk Factors, Time Factors, Young Adult, Occupational Stress epidemiology, Peripheral Arterial Disease epidemiology
Abstract

Background Job strain is implicated in many atherosclerotic diseases, but its role in peripheral artery disease (PAD) is unclear. We investigated the association of job strain with hospital records of PAD, using individual-level data from 11 prospective cohort studies from Finland, Sweden, Denmark, and the United Kingdom. Methods and Results Job strain (high demands and low control at work) was self-reported at baseline (1985-2008). PAD records were ascertained from national hospitalization data. We used Cox regression to examine the associations of job strain with PAD in each study, and combined the study-specific estimates in random effects meta-analyses. We used τ 2 , I 2 , and subgroup analyses to examine heterogeneity. Of the 139 132 participants with no previous hospitalization with PAD, 32 489 (23.4%) reported job strain at baseline. During 1 718 132 person-years at risk (mean follow-up 12.8 years), 667 individuals had a hospital record of PAD (3.88 per 10 000 person-years). Job strain was associated with a 1.41-fold (95% CI, 1.11-1.80) increased average risk of hospitalization with PAD. The study-specific estimates were moderately heterogeneous (τ 2 =0.0427, I 2 : 26.9%). Despite variation in their magnitude, the estimates were consistent in both sexes, across the socioeconomic hierarchy and by baseline smoking status. Additional adjustment for baseline diabetes mellitus did not change the direction or magnitude of the observed associations. Conclusions Job strain was associated with small but consistent increase in the risk of hospitalization with PAD, with the relative risks on par with those for coronary heart disease and ischemic stroke.

Published
2020
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46. Segment 4 occlusion in portal vein embolization increase future liver remnant hypertrophy - A Scandinavian cohort study.

Author

Björnsson B, Hasselgren K, Røsok B, Larsen PN, Urdzik J, Schultz NA, Carling U, Fallentin E, Gilg S, Sandström P, Lindell G, and Sparrelid E

Subjects
Adult, Aged, Aged, 80 and over, Embolization, Therapeutic methods, Female, Humans, Hypertrophy, Liver Neoplasms surgery, Male, Middle Aged, Retrospective Studies, Embolization, Therapeutic adverse effects, Liver pathology, Portal Vein
Abstract

Background: The additional value of including segment 4 (S4) portal branches in right portal vein embolization (rPVE) is debated. The aim of the study was to explore this in a large multicenter cohort., Material and Methods: A retrospective cohort study consisting of all patients subjected to rPVE from August 2012 to May 2017 at six Scandinavian university hospitals. PVE technique was essentially the same in all centers, except for the selection of main embolizing agent (particles or glue). All centers used coils or particles to embolize S4 branches. A subgroup analysis was performed after excluding patients with parts of or whole S4 included in the future liver remnant (FLR)., Results: 232 patients were included in the study, of which 36 received embolization of the portal branches to S4 in addition to rPVE. The two groups (rPVE vs rPVE + S4) were similar (gender, age, co-morbidity, diagnosis, neoadjuvant chemotherapy, bilirubin levels prior to PVE and embolizing material), except for diabetes mellitus which was more frequent in the rPVE + S4 group (p = 0.02). Pre-PVE FLR was smaller in the S4 group (333 vs 380 ml, p = 0.01). rPVE + S4 resulted in a greater percentage increase of the FLR size compared to rPVE alone (47 vs 38%, p = 0.02). A subgroup analysis, excluding all patients with S4 included in the FLR, was done. There was no longer a difference in pre-PVE FLR between groups (333 vs 325 ml, p = 0.9), but still a greater percentage increase and also absolute increase of the FLR in the rPVE + S4 group (48 vs 38% and 155 vs 112 ml, p = 0.01 and 0.02)., Conclusion: In this large multicenter cohort study, additional embolization of S4 did demonstrate superior growth of the FLR compared to standard right PVE., Competing Interests: Declaration of competing interest The authors do not have any conflict of interest to report., (Copyright © 2020 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.)

Published
2020
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47. Clinical risk factors in SUDEP: A nationwide population-based case-control study.

Author

Sveinsson O, Andersson T, Mattsson P, Carlsson S, and Tomson T

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Child, Epilepsy, Tonic-Clonic complications, Female, Humans, Male, Middle Aged, Residence Characteristics, Risk Factors, Sweden, Young Adult, Sudden Unexpected Death in Epilepsy etiology
Abstract

Objective: We conducted a nationwide case-control study in Sweden to test the hypothesis that specific clinical characteristics are associated with increased risk of sudden unexpected death in epilepsy (SUDEP)., Methods: The study included 255 SUDEP cases (definite and probable) and 1,148 matched controls. Clinical information was obtained from medical records and the National Patient Register. The association between SUDEP and potential risk factors was assessed by odds ratios (ORs) and 95% confidence intervals (CIs) and interaction assessed by attributable proportion due to interaction (AP)., Results: Experiencing generalized tonic-clonic seizures (GTCS) during the preceding year was associated with a 27-fold increased risk (OR 26.81, 95% CI 14.86-48.38), whereas no excess risk was seen in those with exclusively non-GTCS seizures (OR 1.15, 95% CI 0.54-48.38). The presence of nocturnal GTCS during the last year of observation was associated with a 15-fold risk (OR 15.31, 95% CI 9.57-24.47). Living alone was associated with a 5-fold increased risk of SUDEP (OR 5.01, 95% CI 2.93-8.57) and interaction analysis showed that the combination of not sharing a bedroom and having GTCS conferred an OR of 67.10 (95% CI 29.66-151.88), with AP estimated at 0.69 (CI 0.53-0.85). Among comorbid diseases, a previous diagnosis of substance abuse or alcohol dependence was associated with excess risk of SUDEP., Conclusions: Individuals with GTCS who sleep alone have a dramatically increased SUDEP risk. Our results indicate that 69% of SUDEP cases in patients who have GTCS and live alone could be prevented if the patients were not unattended at night or were free from GTCS., (Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)

Published
2020
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48. A historical perspective on the introduction of laparoscopic basic surgical training in the Caribbean and factors that contribute to sustainability of such training.

Author

Parker M, Ramdass MJ, Cawich S, Fa Si Oen P, and Rosin D

Subjects
Caribbean Region, Clinical Competence, Humans, Program Evaluation, Surgeons, Trinidad and Tobago, Laparoscopy education
Abstract

Objective: To report the development of minimally invasive training courses and workshops in the Caribbean and specifically the establishment of the Basic Surgical Skills Course of the Royal College of Surgeons of England (RCSEng) in Trinidad with respect to their value toward Surgical laparoscopic or minimally invasive training in the Caribbean., Design: & Methods: The literature written on laparoscopy in the region was reviewed and in particular that related to the minimally invasive training courses provided over the period 2004 to 2019 and the development of laparoscopic surgical training described from a historic perspective. The factors that contribute to sustainability of courses were identified., Results: Laparoscopic surgical training courses were sporadically introduced into the Caribbean over the period 2004 to 2019 in countries including Barbados, Curacao, Guyana, St. Lucia, Jamaica and Trinidad & Tobago. These were timed and closely related to the establishment of the Caribbean College of Surgeons (CCOS) with the help of the Royal College of Surgeons of England. However, the only certified course introduced was the Basic Surgical Skills (BSS) course of the RCSEng into Trinidad in 2012. This has now been established as a recognised overseas centre by the RCSEng and provides the Intercollegiate BSS course annually forming a solid basis for trainees to learn safe surgical and laparoscopic skills prior to commencing formal surgical training. This has resulted in the sustainable development of minimally invasive training in Trinidad in particular., Conclusion: Laparoscopic skills courses and workshops have been established in the Caribbean for 15 years beginning circa. 2004 to 2019 and have grown in number and locations throughout the Caribbean. The RCSEng and the CCOS have been instrumental in the development process. Of note, the only recognised overseas training centre for Basic Surgical Skills Course was established in Trinidad & Tobago with the support of the RCSEng and seems to be the main contributor to the successful, regular maintenance of these and other minimally invasive courses in General Surgery, ENT, Gynaecology and other fields on an annual, sustainable basis., (Copyright © 2019 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.)

Published
2019
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49. Endothelial β-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR (Vascular Endothelial Growth Factor Receptor) 2 Expression.

Author

Martowicz A, Trusohamn M, Jensen N, Wisniewska-Kruk J, Corada M, Ning FC, Kele J, Dejana E, and Nyqvist D

Subjects
Animals, Axin Protein metabolism, Blood-Brain Barrier metabolism, Cell Proliferation, Endothelial Cells metabolism, Mice, Transgenic, Microcirculation, Receptor Cross-Talk, Receptor, Notch1 genetics, Receptor, Notch1 metabolism, Vascular Endothelial Growth Factor A metabolism, Vascular Endothelial Growth Factor Receptor-2 genetics, Brain blood supply, Endothelium, Vascular metabolism, Neovascularization, Physiologic, Retina metabolism, Vascular Endothelial Growth Factor Receptor-2 metabolism, Wnt Signaling Pathway, beta Catenin metabolism
Abstract

Objective: Activation of endothelial β-catenin signaling by neural cell-derived Norrin or Wnt ligands is vital for the vascularization of the retina and brain. Mutations in members of the Norrin/β-catenin pathway contribute to inherited blinding disorders because of defective vascular development and dysfunctional blood-retina barrier. Despite a vital role for endothelial β-catenin signaling in central nervous system health and disease, its contribution to central nervous system angiogenesis and its interactions with downstream signaling cascades remains incompletely understood. Approach and Results: Here, using genetically modified mouse models, we show that impaired endothelial β-catenin signaling caused hypovascularization of the postnatal retina and brain because of deficient endothelial cell proliferation and sprouting. Mosaic genetic analysis demonstrated that endothelial β-catenin promotes but is not required for tip cell formation. In addition, pharmacological treatment revealed that angiogenesis under conditions of inhibited Notch signaling depends upon endothelial β-catenin. Importantly, impaired endothelial β-catenin signaling abrogated the expression of the VEGFR (vascular endothelial growth factor receptor)-2 and VEGFR3 in brain microvessels but not in the lung endothelium., Conclusions: Our study identifies molecular crosstalk between the Wnt/β-catenin and the Notch and VEGF-A signaling pathways and strongly suggest that endothelial β-catenin signaling supports central nervous system angiogenesis by promoting endothelial cell sprouting, tip cell formation, and VEGF-A/VEGFR2 signaling.

Published
2019
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50. Comparison of Clostripain and Neutral Protease as Supplementary Enzymes for Human Islet Isolation.

Author

Brandhorst H, Johnson PR, Mönch J, Kurfürst M, Korsgren O, and Brandhorst D

Subjects
Aged, Female, Humans, Islets of Langerhans Transplantation, Male, Middle Aged, Collagenases metabolism, Cysteine Endopeptidases metabolism, Islets of Langerhans metabolism, Peptide Hydrolases metabolism
Abstract

Although human islet transplantation has been established as valid and safe treatment for patients with type 1 diabetes, the utilization rates of human pancreases for clinical islet transplantation are still limited and substantially determined by the quality and composition of collagenase blends. While function and integrity of collagenase has been extensively investigated, information is still lacking about the most suitable supplementary neutral proteases. The present study compared islet isolation outcome after pancreas digestion by means of collagenase used alone or supplemented with either neutral protease (NP), clostripain (CP), or both proteases. Decent amounts of islet equivalents (IEQ) were isolated using collagenase alone (3090 ± 550 IEQ/g), or in combination with NP (2340 ± 450 IEQ/g) or CP (2740 ± 280 IEQ/g). Nevertheless, the proportion of undigested tissue was higher after using collagenase alone (21.1 ± 1.1%, P < 0.05) compared with addition of NP (13.3 ± 2.2%) or CP plus NP (13.7 ± 2.6%). Likewise, the percentage of embedded islets was highest using collagenase only (13 ± 2%) and lowest adding NP plus CP (4 ± 1%, P < 0.01). The latter combination resulted in lowest post-culture overall survival (42.7 ± 3.9%), while highest survival was observed after supplementation with CP (74.5 ± 4.8%, P < 0.01). An insulin response toward glucose challenge was present in all experimental groups, but the stimulation index was significantly decreased using collagenase plus NP (2.0 ± 0.12) compared with supplementation with CP (3.16 ± 0.4, P < 0.001). This study demonstrates for the first time that it is possible to isolate significant numbers of human islets combining collagenase only with CP. The supplementation with CP is an effective means to substantially reduce NP activity, which significantly decreases survival and viability after culture. This will facilitate the manufacturing of enzyme blends with less harmful characteristics.

Published
2019
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