917 results on '"University of Tartu, Estonia"'
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2. Authorship and copyright ownership in the digital oral archives domain: The Gra.fo digital archive in the CLARIN-IT repository
- Author
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Calamai, Silvia, Kolletzek, Chiara, Aleksei Kelli: University of Tartu, Estonia, and Francesca Biliotti: University of Siena, Italy
- Subjects
oral archive, metadata description, authorship, copyright ownership ,metadata description ,oral archive ,authorship ,copyright ownership - Published
- 2018
3. 'Changes in test-taking patterns over time' concerning the Flynn Effect in Estonia
- Author
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Must, Olev (Department Of Psychology, University Of Tartu, Estonia) and Must, Aasa (Estonian National Defence College, Estonia)
- Published
- 2013
- Full Text
- View/download PDF
4. Religion as a (re)source of contentious politics?
- Author
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Gender, Sexuality and Reproduction in Central and Eastern Europe: Religious Actors and Secular Norms in Contentious Politics (21-22/05/2015: University of Tartu, Estonia), Foret, François, Gender, Sexuality and Reproduction in Central and Eastern Europe: Religious Actors and Secular Norms in Contentious Politics (21-22/05/2015: University of Tartu, Estonia), and Foret, François
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 2015
5. TRY plant trait database – enhanced coverage and open access
- Author
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Kattge, J., Bonisch, G., Diaz, S., Lavorel, S., Prentice, I. C., Leadley, P., Tautenhahn, S., Werner, G. D. A., Aakala, T., Abedi, M., Acosta, A. T. R., Adamidis, G. C., Adamson, K., Aiba, M., Albert, C. H., Alcantara, J. M., Alcazar, C C., Aleixo, I., Ali, H., Amiaud, B., Ammer, C., Amoroso, M. M., Anand, M., Anderson, C., Anten, N., Antos, J., Apgaua, D. M. G., Ashman, T. L., Asmara, D. H., Asner, G. P., Aspinwall, M., Atkin, O., Aubin, I., Baastrup-Spohr, L., Bahalkeh, K., Bahn, M., Baker, T., Baker, W. J., Bakker, J. P., Baldocchi, D., Baltzer, J., Banerjee, A., Baranger, A., Barlow, J., Barneche, D. R., Baruch, Z., Bastianelli, D., Battles, J., Bauerle, W., Bauters, M., Bazzato, E., Beckmann, M., Beeckman, H., Beierkuhnlein, C., Bekker, R., Belfry, G., Belluau, M., Beloiu, M., Benavides, R., Benomar, L., Berdugo-Lattke, M. L., Berenguer, E., Bergamin, R., Bergmann, J., Bergmann Carlucci, M., Berner, L., Bernhardt Romermann, M., Bigler, C., Bjorkman, A. D., Blackman, C., Blanco, C., Blonder, B., Blumenthal, D., Bocanegra Gonzalez, K. T., Boeckx, P., Bohlman, S., Bohning Gaese, K., Boisvert Marsh, L., Bond, W., Bond-Lamberty, B., Boom, A., Boonman, C. C. F., Bordin, K., Boughton, E. H., Boukili, V., Bowman, D. M. J. S., Bravo, S., Brende, l M. R., Broadley, M. R., Brown, K. A., Bruelheide, H., Brumnich, F., Bruun, H. H., Bruy, D., Buchanan, S. W., Bucher, S. F., Buchmann, N., Buitenwerf, R., Bunker, D. E., Burge, r J., Burrascano, S., Burslem, D. F. R. P., Butterfield, B. J., Byun, C., Marques, M., Scalon, M. C., Caccianiga, M., Cadotte, M., Cailleret, M., Camac, J., Camarero, J. J., Campany, C., Campetella, G., Campos, J. A., Cano Arboleda, L., Canullo, R., Carbognani, M., Carvalho, F., Casanoves, F., Castagneyrol, B., Catford, J. A., Cavender Bares, J., Cerabolini, B. E. L., Cervellini, M., Chacon Madrigal, E., Chapin, K., Chapin, F. S., Chelli, S., Chen, S. C., Chen, A., Cherubini, P., Chianucci, F., Choat, B., Chung, K. S., Chytry, M., Ciccarelli, D., Coll, L., Collins, C. G., Conti, L., Coomes, D., Cornelissen, J. H. C., Cornwell, W. K., Corona, P., Coyea, M., Craine, J., Craven, D., Cromsigt, J. P. G. M., Csecserits, A., Cufar, K., Cuntz, M., da Silva, A. C., Dahlin, K. M., Dainese, M., Dalke, I., Dalle Fratte, M., Dang Le, A. T., Danihelka, J., Dannoura, M., Dawson, S., de Beer, A. J., De Frutos, A., De Long, J. R., Dechant, B., Delagrange, S., Delpierre, N., Derroire, G., Dias, A. S., Diaz Toribio, M. H., Dimitrakopoulos, P. G., Dobrowolski, M., Doktor, D., Drevojan, P., Dong, N., Dransfield, J., Dressler, S., Duarte, L., Ducouret, E., Dullinger, S., Durka, W., Duursma, R., Dymova, O., E- Vojtko, A., Eckstein, R. L., Ejtehadi, H., Elser, J., Emilio, T., Engemann, K., Erfanian, M. B., Erfmeier, A., Esquivel Muelbert, A., Esser, G., Estiarte, M., Domingues, T. F., Fagan, W. F., Fagundez, J., Falster, D. S., Fan, Y., Fang, J., Farris, E., Fazlioglu, F., Feng, Y., Fernandez, Mendez, Ferrara, C., Ferreira, J., Fidelis, A., Finegan, B., Firn, J., Flowers, T. J., Flynn, D. F. B., Fontana, V., Forey, E., Forgiarini, C., Francois, L., Frangipani, M., Frank, D., Frenette Dussault, C., Freschet, G. T., Fry, E. L., Fyllas, N. M., Mazzochini, G. G., Gachet, S., Gallagher, R., Ganade, G., Ganga, F., Garcia Palacios, P., Gargaglione, V., Garnier, E., Garrido, J. L., de Gasper, A. L., Gea Izquierdo, G., Gibson, D., Gillison, A. N., Giroldo, A., Glasenhardt, M. C., Gleason, S., Gliesch, M., Goldberg, E., Goldel, B., Gonzalez Akre, E., Gonzalez Andujar, J. L., Gonzalez Melo, A., Gonzalez Robles, A., Graae, B. J., Granda, E., Graves, S., Green, W. A., Gregor, T., Gross, N., Guerin, G. R., Gunther, A., Gutierrez, A. G., Haddock, L., Haines, A., Hall, J., Hambuckers, A., Han, W., Harrison, S. P., Hattingh, W., Hawes, J. E., He, T., He, P., Heberling, J. M., Helm, A., Hempel, S., Hentschel, J., Herault, B., Heres, A. M., Herz, K., Heuertz, M., Hickler, T., Hietz, P., Higuchi, P., Hipp, A. L., Hirons, A., Hock, M., Hogan, J. A., Holl, K., Honnay, O., Hornstein, D., Hou, E., Hough Snee, N., Hovstad, K. A., Ichie, T., Igic, B., Illa, E., Isaac, M., Ishihara, M., Ivanov, L., Ivanova, L., Iversen, C. M., Izquierdo, J., Jackson, R. B., Jackson, B., Jactel, H., Jagodzinsk, A. M., Jandt, U., Jansen, S., Jenkins, T., Jentsch, A., Jespersen, J. R. P., Jiang, G. F., Johansen, J. L., Johnson, D., Jokela, E. J., Joly, C. A., Jordan, G. J., Joseph, G. S., Junaedi, D., Junker, R. R., Justes, E., Kabzems, R., Kane, J., Kaplan, Z., Kattenborn, T., Kavelenova, L., Kearsley, E., Kempel, A., Kenzo, T., Kerkhoff, A., Khalil, M. I., Kinlock, N. L., Kissling, W. D., Kitajima, K., Kitzberger, T., Kjoller, R., Klein, T., Kleyer, M., Klimesova, J., Klipel, J., Kloeppel, B., Klotz, S., Knops, J. M. H., Kohyama, T., Koike, F., Kollmann, J., Komac, B., Komatsu, K., Konig, C., Kraft, N. J. B., Kramer, K., Kreft, H., Kuhn, I., Kumarathune, D., Kuppler, J., Kurokawa, H., Kurosawa, Y., Kuyah, S., Laclau, J. P., Lafleur, B., Lallai, E., Lamb, E., Lamprecht, A., Larkin, D. J., Laughlin, D., Le Bagousse Pinguet, Y., le Maire, G., le Roux, P. C., le Roux, E., Lee, T., Lens, F., Lewis, S. L., Lhotsky, B., Li, Y., Li, X., Lichstein, J. W., Liebergesell, M., Lim, J. Y., Lin, Y. S., Linares, Y. C., Liu, C., Liu, D., Liu, U., Livingstone, S., Llusia, J., Lohbeck, M., Lopez Garcia, A., Lopez Gonzalez, G., Lososov, a Z., Louault, F., Lukacs, B. A., Lukes, P., Luo, Y., Lussu, M., Ma, S., Maciel Rabelo Pereira, C., Mack, M., Maire, V., Makela, A., Makinen, H., Malhado, A. C. M., Mallik, A., Manning, P., Manzoni, S., Marchetti, Z., Marchino, L., Marcilio Silva, V., Marcon, E., Marignani, M., Markesteijn, L., Martin, A., Martinez Garza, C., Martinez Vilalta, J., Maskova, T., Mason, K., Mason, N., Massad, T. J., Masse, J., Mayrose, I., Mccarthy, J., Mccormack, M. L., Mcculloh, K., Mcfadden, I., Mcgill, B. J., Mcpartland, M. Y., Medeiros, J., Medlyn, B., Meerts, P., Mehrabi, Z., Meir, P., Melo, F., P. L., Mencuccini, M., Meredieu, C., Messier, J., Meszaros, I., Metsaranta, J., Michaletz, S. T., Michelaki, C., Migalina, S., Milla, R., Miller, J., E. D., Minden, V., Ming, R., Mokany, K., Moles, A. T., Molnar, A., Molofsky, J., Molz, M., Montgomery, R. A., Monty, A., Moravcova, L., Moreno Martinez, A., Moretti, M., Mori, A. S., Mori, S., Morris, D., Morrison, J., Mucina, L., Mueller, S., Muir, C. D., Muller, S. C., Munoz, F., Myers Smith, I. H., Myster, R. W., Nagano, M., Naidu, S., Narayanan, A., Natesan, B., Negoita, L., Nelson, A. S., Neuschulz, E. L., Ni, J., Niedrist, G., Nieto, J., Niinemets, U., Nolan, R., Nottebrock, H., Nouvellon, Y., Novakovskiy, A., Nystuen, K. O., O'Grady, A., O'Hara, K., O'Reilly Nugent, A., Oakley, S., Oberhuber, W., Ohtsuka, T., Oliveira, R., Ollerer, K., Olson, M. E., Onipchenko, V., Onoda, Y., Onstein, R. E., Ordonez, J. C., Osada, N., Ostonen, I., Ottaviani, G., Otto, S., Overbeck, G. E., Ozinga, W. A., Pahl, A. T., Paine, C. E. T., Pakeman, R. J., Papageorgiou, A. C., Parfionova, E., Partel, M., Patacca, M., Paula, S., Paule, J., Pauli, H., Pausas, J., Peco, B., Penuelas, J., Perea, A., Peri, P. L., Petisco Souza, A. C., Petraglia, A., Petritan, A. M., Phillips, O. L., Pierce, S., Pillar, V. D., Pisek, J., Pomogaybin, A., Poorter, H., Portsmuth, A., Poschlod, P., Potvin, C., Pounds, D., Powell, A., Power, S. A., Prinzing, A., Puglielli, G., Pysek, P., Raevel, V., Rammig, A., Ransijn, J., Ray, C. A., Reich, P. B., Reichstein, M., Reid, D. E. B., Rejou Mechain, M., de Dios, V. R., Ribeiro, S., Richardson, S., Riibak, K., Rillig, M. C., Riviera, F., Robert, E. M. R., Roberts, S., Robroek, B., Roddy, A., Rodrigues, A. V., Rogers, A., Rollinson, E., Rolo, V., Romermann, C., Ronzhina, D., Roscher, C., Rosell, J. A., Rosenfield, M. F., Rossi, C., Roy, D. B., Royer Tardif, S., Ruger, N., Ruiz Peinado, R., Rumpf, S. B., Rusch, G. M., Ryo, M., Sack, L., Saldana, A., Salgado Negret, B., Salguero Gomez, R., Santa Regina, I., Santacruz Garcia, A. C., Santos, J., Sardans, J., Schamp, B., Scherer Lorenzen, M., Schleuning, M., Schmid, B., Schmidt, M., Schmitt, S., Schneider, J. V., Schowanek, S. D., Schrader, J., Schrodt, F., Schuldt, B., Schurr, F., Selaya Garvizu, G., Semchenko, M., Seymour, C., Sfair, J. C., Sharpe, J. M., Sheppard, C. S., Sheremetiev, S., Shiodera, S., Shipley, B., Shovon, T. A., Siebenkas, A., Sierra, C., Silva, V., Silva, M., Sitzia, T., Sjoman, H., Slot, M., Smith, N. G., Sodhi, D., Soltis, P., Soltis, D., Somers, B., Sonnier, G., Sorensen, M. V., Sosinski, E. E., Soudzilovskaia, N. A., Souza, A. F., Spasojevic, M., Sperandii, M. G., Stan, A. B., Stegen, J., Steinbauer, K., Stephan, J. G., Sterck, F., Stojanovic, D. B., Strydom, T., Suarez, M. L., Svenning, J. C., Svitkova, I., Svitok, M., Svoboda, M., Swaine, E., Swenson, N., Tabarelli, M., Takagi, K., Tappeiner, U., Tarifa, R., Tauugourdeau, S., Tavsanoglu, C., te Beest, M., Tedersoo, L., Thiffault, N., Thom, D., Thomas, E., Thompson, K., Thornton, P. E., Thuiller, W., Tichy, L., Tissue, D., Tjoelker, M. G., Tng, D. Y. P., Tobias, J., Torok, P., Tarin, T., Torres Ruiz, J. M., Tothmeresz, B., Treurnicht, M., Trivellone, V., Trolliet, F., Trotsiuk, V., Tsakalos, J. L., Tsiripidis, I., Tysklind, N., Umehara, T., Usoltsev, V., Vadeboncoeur, M., Vaezi, J., Valladares, F., Vamosi, J., van Bodegom, P. M., van Breugel, M., Van Cleemput, E., van de Weg, M., van der Merwe, S., van der Plas, F., van der Sande, M. T., van Kleunen, M., Van Meerbeek, K., Vanderwel, M., Vanselow, K. A., Varhammar, A., Varone, L., Vasquez Valderrama, M. Y., Vassilev, K., Vellend, M., Veneklaas, E. J., Verbeeck, H., Verheyen, K., Vibrans, A., Vieira, I., Villacis, J., Violle, C., Vivek, P., Wagner, K., Waldram, M., Waldron, A., Walker, A . P., Waller, M., Walther, G., Wang, H., Wang, F., Wang, W., Watkins, H., Watkins, J., Weber, U., Weedon, J. T., Wei, L., Weigelt, P., Weiher, E., Wells, A. W., Wellstein, C., Wenk, E., Westoby, M., Westwood, A., White, P. J., Whitten, M., Williams, M., Winkler, D. E., Winter, K., Womack, C., Wright, I. J., Wright, S. J., Wright, J., Pinho, B. X., Ximenes, F., Yamada, T., Yamaji, K., Yanai, R., Yankov, N., Yguel, B., Zanini, K. J., Zanne, A. E., Zeleny, D., Zhao, Y. P., Zheng, J., Zieminska, K., Zirbel, C. R., Zizka, G., Zo Bi, I. C., Zotz, G., Wirth, C., Systèmes d'élevage méditerranéens et tropicaux (UMR SELMET), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant - Clermont Auvergne (PIAF), Université Clermont Auvergne (UCA)-Institut National de la Recherche Agronomique (INRA), Botanique et Modélisation de l'Architecture des Plantes et des Végétations (UMR AMAP), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Biodiversité, Gènes & Communautés (BioGeCo), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB), SILVA (SILVA), AgroParisTech-Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Ecologie des forêts de Guyane (UMR ECOFOG), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Unité Mixte de Recherche sur l'Ecosystème Prairial - UMR (UREP), Institut National de la Recherche Agronomique (INRA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Unité Expérimentale Forêt Pierroton (UEFP), Institut National de la Recherche Agronomique (INRA), Max Planck Institute for Biogeochemistry Max Planck SocietyFoundation CELLEX German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig International Programme of Biodiversity Science (DIVERSITAS) International Geosphere-Biosphere Programme (IGBP) French Foundation for Biodiversity Research (FRB) GIS 'Climat, Environnement et Societe' France AXA Research Fund NERC Natural Environment Research Council Future Earth, Max Planck Institute for Biogeochemistry (MPI-BGC), Max-Planck-Gesellschaft, German Centre for Integrative Biodiversity Research (iDiv), Instituto Multidisciplinario de Biología Vegetal [Córdoba] (IMBIV), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Facultad de Ciencias Exactas, Físicas y Naturales [Córdoba], Universidad Nacional de Córdoba [Argentina]-Universidad Nacional de Córdoba [Argentina], Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Imperial College London, Ecologie Systématique et Evolution (ESE), AgroParisTech-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Department of Zoology [Oxford], University of Oxford, Balliol College, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Tarbiat Modares University [Tehran], Università degli Studi Roma Tre = Roma Tre University (ROMA TRE), Department of Environment [Aegean], University of the Aegean, Institute of Ecology and Evolution [Bern, Switzerland], University of Bern, University of Tartu, Tohoku University [Sendai], Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Universidad de Jaén (UJA), Instituto Alexander Von Humboldt, Bogota, Colombia, National Institute of Amazonian Research (INPA), Manaus, Brazil, Botany Department, Faculty of Science, Suez Canal University, Ismailia, Egypt, Laboratoire Agronomie et Environnement - Antenne Colmar (LAE-Colmar ), Laboratoire Agronomie et Environnement (LAE), Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Lorraine (UL)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Forest Sciences, University of Göttingen, Göttingen, Germany, Centre for Biodiversity and Sustainable Land-use [University of Göttingen] (CBL), Georg-August-University = Georg-August-Universität Göttingen, Instituto de Investigaciones en Recursos Naturales, Agroecología y Desarrollo Rural (IRNAD), Universidad Nacional de Río Negro, El Bolsón, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), School of Environmental Sciences, University of Guelph, Pacific Northwest National Laboratory, Richland, WA, USA, University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS), Centre for Crop Systems Analysis, Wageningen University and Research [Wageningen] (WUR), University of Victoria [Canada] (UVIC), College of Science & Engineering, James Cook University, Smithfield, Qld, Australia, University of Pittsburgh, Pittsburgh, PA, USA, Centre for Forest Research, Institute for Integrative Systems Biology, Université Laval, Quebec, QC, Canada, Arizona State University, Tempe, AZ, USA, University of North Florida [Jacksonville] (UNF), Australian National University (ANU), Great Lakes Forestry Centre, Canadian Forest Service, Natural Resources Canada, Sault Ste. Marie, ON, Canada, Department of Biology [Copenhagen], Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Department of Ecology [Innsbruck], Leopold Franzens Universität Innsbruck - University of Innsbruck, University of Leeds, Royal Botanic Gardens Kew, Richmond, UK, Conservation Ecology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands, Lawrence Berkeley National Laboratory [Berkeley] (LBNL), Biology Department, Wilfrid Laurier University, Waterloo, ON, Canada, Department of Forest Resources, University of Minnesota, St. Paul, MN, USA, AgroParisTech, Lancaster Environment Centre, Lancaster University, University of Exeter, University of Adelaide, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Département Environnements et Sociétés (Cirad-ES), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), University of California [Berkeley] (UC Berkeley), University of California (UC), Department of Horticulture and Landscape Architecture, Colorado State University, Fort Collins, CO, USA, Universiteit Gent = Ghent University (UGENT), Università degli Studi di Cagliari = University of Cagliari (UniCa), Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Royal Museum for Central Africa, Tervuren, Belgium, Bayreuth Center of Ecology and Environmental Research (BayCEER), Groningen Institute of Archaeology (GIA), University of Groningen, Groningen, The Netherlands, Department of Biological Sciences, University of Tennessee, Knoxville, TN, USA, Rocky Mountain Biological Laboratory, Crested Butte, CO, USA, Département des Science, Université du Québec À Montréal, Montreal, QC, Canada, Department of Biogeography, University of Bayreuth, Bayreuth, Germany, Museo Nacional de Ciencias Naturales [Madrid] (MNCN), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université Laval, Quebec, QC, Canada, Instituto de Ciencias Naturales, Universidad Nacional de Colombia, Bogota, Colombia, Fundación Natura, Bogota, Colombia, Environmental Change Institute, Laboratório de Estudos em Vegetação Campestre (LEVCamp), Programa de Pós-Graduação em Botânica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, Freie Universität Berlin, Berlin-Brandenburg Institute of Advanced Biodiversity Research (BBIB), Berlin, Germany, Laboratório de Ecologia Funcional de Comunidades (LABEF), Departamento de Botânica, Universidade Federal do Paraná, Curitiba, Brazil, School of Informatics, Computing, and Cyber Systems (SICCS), Northern Arizona University [Flagstaff], Institute of Ecology and Evolution, Friedrich Schiller University Jena, Jena, Germany, ETH Zurich, Universitatstrasse 16, 8092 Zurich, Switzerland, University of Gothenburg (GU), Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant (PIAF), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), School of Life Sciences, Arizona State University, Tempe, AZ, USA, USDA-ARS Rangeland Resources & Systems Research Unit, Fort Collins, CO, USA, Grupo de Investigación en Biodiversidad y Dinámica de Ecosistémas Tropicales - Universidad del Tolima, Ibagué, Colombia, Laboratory of Applied Physical Chemistry - ISOFYS (Gent, Belgium), School of Forest Resources and Conservation [Gainesville] (UF|IFAS|FFGS), Institute of Food and Agricultural Sciences [Gainesville] (UF|IFAS), University of Florida [Gainesville] (UF)-University of Florida [Gainesville] (UF), Senckenberg Biodiversity and Climate Research Centre, Frankfurt am Main, Germany, Department of Biological Sciences, Goethe Universität Frankfurt, Frankfurt am Main, Germany, Department of Biological Sciences, University of Cape Town, Cape Town, South Africa, SAEON Fynbos Node, Claremont, South Africa, Pacific Northwest National Laboratory, College Park, MD, USA, University of Leicester, Department of Environmental Science, Institute for Water and Wetland Research, Radboud University, Nijmegen, The Netherlands, Laboratório de Ecologia Vegetal (LEVEG), Programa de Pós-Graduação em Ecologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, Archbold Biological Station’s Buck Island Ranch, FL, Lake Placid, USA, Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT, USA, University of Tasmania [Hobart, Australia] (UTAS), Facultad de Ciencias Forestales, Universidad Nacional de Santiago del Estero, Santiago del Estero, Argentina, Universität Hohenheim, School of Geography, University of Nottingham, Nottingham, UK, Department of Geography and Geology, Kingston University, Kingston upon Thames, UK, Martin-Luther-Universität Halle Wittenberg (MLU), Facultad de Ingeniería y Ciencias Hídricas, Universidad Nacional del Litoral (FICH-UNL), Santa Fe, Argentina, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie]), University of Toronto at Scarborough, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Section for Ecoinformatics and Biodiversity, Department of Bioscience, Aarhus University, Aarhus, Denmark, Center for Biodiversity Dynamics in a Changing World (BIOCHANGE), Department of Bioscience, Aarhus University, Aarhus, Denmark, New Jersey Institute of Technology [Newark] (NJIT), University of Rostock, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), School of Biological Sciences, University of Aberdeen, Aberdeen, UK, Center for Ecosystem Science and Society, Northern Arizona University, Flagstaff, AZ, USA, School of Civil and Environmental Engineering, Yonsei University, Seoul, Korea, Departamento de Botânica, SCB, UFPR – Federal University of Parana, Curitiba, Brazil, Centro Politécnico, Universidade Federal do Paraná, Curitiba, Brazil, Università degli Studi di Milano = University of Milan (UNIMI), Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Environmental Systems Science, ETH Zürich, Zürich, Switzerland, Swiss Federal Institute for Forest, Snow and Landscape Research WSL, Centre of Excellence for Bioscurity Risk Analysis, The University of Melbourne, Melbourne, Vic., Australia, Centro de Investigaciones Biológicas (CSIC), Colgate University, Hamilton, NY, USA, School of Biosciences and Veterinary Medicine, Plant Diversity and Ecosystems Management Unit, University of Camerino, Camerino, Italy, University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Departamento de Geociencias y Medio Ambiente, Universidad Nacional de Colombia, Medellin, Colombia, Università degli studi di Parma = University of Parma (UNIPR), Centro Agronómico Tropical de Investigación y Enseñanza - Tropical Agricultural Research and Higher Education Center (CATIE), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Geography, King’s College London, London, UK, University of Minnesota [Twin Cities] (UMN), University of Minnesota System, Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Universidad de Costa Rica (UCR), University of Arizona, Institute of Arctic Biology, University of Alaska [Fairbanks] (UAF), Royal Botanic Gardens [Kew], Department of Biology [Fort Collins], Colorado State University [Fort Collins] (CSU), WSL Swiss Federal Research Institute, Birmensdorf, Switzerland, Faculty of Forestry, University of British Columbia, Vancouver, BC, Canada, CREA – Research Centre for Forestry and Wood, Arezzo, Italy, Western Sydney University, ungwon University, Goesan, Chungbuk, Korea, Department of Botany and Zoology [Brno] (SCI / MUNI), Faculty of Science [Brno] (SCI / MUNI), Masaryk University [Brno] (MUNI)-Masaryk University [Brno] (MUNI), University of Pisa - Università di Pisa, Department of Agriculture and Forest Engineering (EAGROF), University of Lleida, Lleida, Spain, Joint Research Unit CTFC – AGROTECNIO, Solsona, Spain, University of California Riverside, Riverside, CA, USA, Faculty of Environmental Sciences, University of Life Sciences Prague, Institute of Botany of the Czech Academy of Sciences (IB / CAS), Czech Academy of Sciences [Prague] (CAS), University of Cambridge [UK] (CAM), Systems Ecology, Department of Ecological Science, Vrije Universiteit, Amsterdam, The Netherlands, School of Biological, Earth and Environmental Sciences, UNSW Sydney, Sydney, NSW, Australia, Faculté de foresterie, de géographie et de géomatique, Université Laval, Quebec, QC, Canada, Jonah Ventures, Boulder, CO, USA, Centro de Modelación y Monitoreo de Ecosistemas, Universidad Mayor, Santiago, Chile, Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences (SLU), Centre for African Conservation Ecology, Department of Zoology, Nelson Mandela University, Port Elizabeth, South Africa, MTA Centre for Ecological Research [Tihany], Hungarian Academy of Sciences (MTA), University of Ljubljana, Santa Catarina State University, Lages, SC, Brazil, Department of Geography, Environment, and Spatial Sciences, Michigan State University, East Lansing, MI, USA, Eurac Research, Institute for Alpine Environment, Bozen-Bolzano, Italy, Institute of Biology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, Syktyvkar, Komi Republic, Russia, University of Science – Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam, Graduate School of Agriculture, Kyoto University, Kyoto, Japan, Graduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan, Swedish Species Information Centre, University of Pretoria [South Africa], Helmholtz Centre for Environmental Research – UFZ, Leipzig, Germany, Department of Terrestrial Ecology, Netherlands Institute of Ecology, Wageningen, The Netherlands, Department Computational Landscape Ecology [UFZ Leipsig], Department Computational Hydrosystems, UFZ – Helmholtz Centre for Environmental Research, Leipzig, Germany, Seoul National University [Seoul] (SNU), Institute of Temperate Forest Sciences (ISFORT), Ripon, QC, Canada, UQO, Department of Natural Sciences, Ripon, QC, Canada, Université Paris-Sud - Paris 11 (UP11)-AgroParisTech-Centre National de la Recherche Scientifique (CNRS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Goethe-Universität Frankfurt am Main, University of Florida [Gainesville] (UF), The University of Western Australia (UWA), School of Biological Sciences, The University of Western Australia, Department of Biological Sciences, Macquarie University, Department of Botany and Molecular Evolution, Senckenberg Research Institute and Natural History Museum, Universität Wien, Karlstad University [Sweden], Ferdowsi University of Mashhad (FUM), Flathead Lake Biological Station, University of Montana, School of Sustainability, Arizona State University, Programa Nacional de Pós-Doutorado (PNPD), Programa de Pós Graduação em Ecologia, Institute of Biology, University of Campinas UNICAMP, Institute for Ecosystem Research/Geobotany, Kiel University, School of Geography, Earth and Environmental Sciences [Birmingham], University of Birmingham [Birmingham], Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Global Ecology Unit CREAF-CEAB-CSIC, Universitat Autònoma de Barcelona (UAB), FFCLRP-USP, Department of Biology [USA], University of Maryland [College Park], University of Maryland System-University of Maryland System, University of A Coruña (UDC), School of Physics [UNSW Sydney] (UNSW), University of New South Wales [Sydney] (UNSW), Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Peking, Peking University [Beijing], Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Ordu University - Ordu Üniversitesi, Lanzhou University, Universidad del Tolima, Research Centre for Forestry and Wood, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria = Council for Agricultural Research and Economics (CREA), Brazilian Agricultural Research Corporation (Embrapa), Universidade de São Paulo = University of São Paulo (USP), Centro Agronomico Tropical de Investigacion y Ensenanza (CATIE), Queensland University of Technology [Brisbane] (QUT), University of Sussex, Harvard University, Institute for Alpine Environment, European Academy of Bozen-Bolzano (EURAC), Étude et compréhension de la biodiversité (ECODIV), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Laboratoire de Physique Atmosphérique et Planétaire (LPAP), Université de Liège, Université de Sherbrooke (UdeS), Station d'écologie théorique et expérimentale (SETE), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, University of Manchester [Manchester], Universidade Estadual de Campinas = University of Campinas (UNICAMP), Macquarie University, Universidade Federal do Rio Grande do Norte [Natal] (UFRN), Universidad Rey Juan Carlos [Madrid] (URJC), Universidad Nacional de la Patagonia Austral (UNPA), Universidade Regional de Blumenau (FURB), INIA-CIFOR, Southern Illinois University [Carbondale] (SIU), Center for Biodiversity Management, Instituto Federal de Educação Ciência e Tecnologia do Cearà, The Morton Arboretum, United States Department of Agriculture (USDA), Swiss Federal Institute of Technology, Aarhus University [Aarhus], Smithsonian Conservation Biology Institute, Centre Supérieur de la Recherche Scientifique (CSIC), Centre Supérieur de la Recherche Scientifique, Universidad del Rosario [Bogota], Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Université Paris Sud (Paris 11), Senckenberg Research Institutes and Natural History Museums, Universidad de Chile = University of Chile [Santiago] (UCHILE), Joint Global Change Research Institute, Pacific Northwest National Laboratory (PNNL)-University of Maryland [College Park], Smithsonian Tropical Research Institute, University of Liege, Université de Liège - Gembloux, Institut Pasteur de Shanghai, Académie des Sciences de Chine - Chinese Academy of Sciences (IPS-CAS), Réseau International des Instituts Pasteur (RIIP), University of Bristol [Bristol], University of the Witwatersrand [Johannesburg] (WITS), Norwegian University of Life Sciences (NMBU), Murdoch University, Carnegie Museum of Natural History [Pittsburgh], Transilvania University of Brasov, Martin-Luther-University Halle-Wittenberg, Senckenberg Biodiversity and Climate Research Centre (SBiK-F), Goethe-Universität Frankfurt am Main-Senckenberg – Leibniz Institution for Biodiversity and Earth System Research - Senckenberg Gesellschaft für Naturforschung, Leibniz Association-Leibniz Association, Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Santa Catarina State University (UDESC), University Centre Myerscough, Kiel University, Florida International University [Miami] (FIU), Division of Plant Ststematic and Ecology, Biology department, Université Catholique de Louvain = Catholic University of Louvain (UCL), University of Applied Sciences of Weihenstephan, Four Peaks Environmental Science and Data Solutions, Norsk institutt for bioøkonomi=Norwegian Institute of Bioeconomy Research (NIBIO), Kochi University of Technology (KUT), University of Illinois [Chicago] (UIC), University of Illinois System, Universitat de Barcelona (UB), Kyoto University, Tyumen State University, Oak Ridge National Laboratory [Oak Ridge] (ORNL), UT-Battelle, LLC, Universitat Politècnica de Catalunya [Barcelona] (UPC), Stanford University, University of Edinburgh, Polish Academy of Sciences (PAN), Philips Research Europe - Hamburg, Sector Medical Imaging Systems, Philips Research, Institute for Systematic Botany and Ecology, Universität Ulm - Ulm University [Ulm, Allemagne], Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Universität Bayreuth, University of Copenhagen = Københavns Universitet (UCPH), Guangxi Normal University, University College of London [London] (UCL), Hobart - Tasmania 7001, University of Venda [South Africa] (UNIVEN), University of Melbourne, Philipps Universität Marburg = Philipps University of Marburg, Agrosystèmes Cultivés et Herbagers (ARCHE), Institut National de la Recherche Agronomique (INRA)-École nationale supérieure agronomique de Toulouse (ENSAT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT), Natural Resource Operations and Rural Development, Humboldt State University (HSU), Charles University [Prague] (CU), Karlsruhe Institute of Technology (KIT), Samara National Research University, Institute of Plant Sciences, Forestry and Forest Products Research Institute (FFPRI), Kenyon College, University of Garmian, State University of New York (SUNY), Institute for Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam [Amsterdam] (UvA), Universidad Nacional del Comahue [Neuquén] (UNCOMA), IT University of Copenhagen (ITU), Agricultural Research Organization, Landscape Ecology Group, University of Oldenburg, Western Carolina University, Xi'an Jiaotong-Liverpool University [Suzhou], Hokkaido University [Sapporo, Japan], Yokohama National University, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Institut d Estudis Andorrans, Smithsonian Environmental Research Center (SERC), Humboldt University Of Berlin, University of California [Los Angeles] (UCLA), Department of Biodiversity, Macroecology and Biogeography, Yamagata University, Jomo Kenyatta University of Agriculture and Technology (JKUAT), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Université du Québec en Abitibi-Témiscamingue (UQAT), University of Saskatchewan [Saskatoon] (U of S), University of Natural Resources and Life Sciences, Institute of Mountain Risk Engineering - Vienna, Austria, University of Wyoming (UW), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), Nelson Mandela University [Port Elizabeth], University of Wisconsin - Eau Claire, Naturalis Biodiversity Center [Leiden], Département de biologie [Sherbrooke] (UdeS), Faculté des sciences [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS)-Université de Sherbrooke (UdeS), Yangzhou University, Leipzig University, University Pablo de Olavide, Shanghai Jiao Tong University [Shanghai], Royal Botanical Gardens, Masaryk University [Brno] (MUNI), Department of Physiology, University of Debrecen Egyetem [Debrecen]-Research Centre for Molecular Medicine-Medical and Health Science Centre, Global Change Research Centre (CzechGlobe), Université du Québec à Trois-Rivières (UQTR), Natural Resources Institute Finland (LUKE), Universidade Federal de Alagoas = Federal University of Alagoas (UFAL), Lakehead University, Stockholm University, Universidad Nacional del Litoral [Santa Fe] (UNL), Universidade Federal do Paraná (UFPR), Bangor University, Universidad Autonoma del Estado de Morelos (UAEM), Manaaki Whenua – Landcare Research [Lincoln], Gorongosa National Park, Université de Montréal (UdeM), Tel Aviv University (TAU), University of Queensland [Brisbane], University of Wisconsin-Madison, University of Maine, Holden Arboretum, Hawkesbury Institute for he Environment, Laboratoire d'Ecologie Végétale et Biogéochimie, Université libre de Bruxelles (ULB), University of British Columbia (UBC), Research School of Biology, Universidade Federal de Pernambuco [Recife] (UFPE), School of Geosciences [Edinburgh], Ecology and Evolutionary Biology [Tucson] (EEB), University of Debrecen, Northern Forestry Centre, Canadian Forest Service - CFS (CANADA), University of Illinois at Urbana-Champaign [Urbana], Data61 [Canberra] (CSIRO), Australian National University (ANU)-Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), University of Debrecen Egyetem [Debrecen], University of Vermont [Burlington], Fundação Zoobotânica do Rio Grande do Sul, University of Montana, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), University of Freiburg [Freiburg], University of Hawaii, Institut Français de Pondichéry (IFP), Ministère de l'Europe et des Affaires étrangères (MEAE)-Centre National de la Recherche Scientifique (CNRS), Oklahoma State University [Stillwater] (OSU), Osaka City University, Charles Darwin Research Station (CDRS), Charles Darwin Foundation, Los Alamos National Laboratory (LANL), Zhejiang Normal University, European Academy of Bolzano, Universidad Distrital Francisco Jose de Caldas [Bogota], University of Bayreuth, Institute of Biology of Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences, Russian Academy of Sciences [Moscow] (RAS), CSIRO Land and Water, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), University of Canberra, CEH, Department of Systems and Science, Graduate School of Informatics, Kyoto University-Kyoto University, Departamento de Telemática, Faculdade de Engenharia Elétrica e de Computação (DT/FEEC), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Moscow State University, Vrije Universiteit Amsterdam [Amsterdam] (VU), Meijo University, Institute of Ecology and Earth Sciences [Tartu], Astronomical Institute of the Czech Academy of Sciences (ASU / CAS), University of Nijmegen, University of New England (UNE), The James Hutton Institute, Democritus University of Thrace (DUTH), Institute of Ecology and Earth Sciences, University of Tartu, Spanish National Research Council (CSIC), Senckenberg Research Institute and Natural History Museum, University of Vienna [Vienna], Center for Desertification Research (CIDE), Universitat de València (UV), Universidad Autónoma de Madrid (UAM), Université de Jaén, National Institute for Research and Development in Forestry, Department of Plant Production (University of Milan), Tartu Observatory, Botanical Garden of the Samara University, Forschungszentrum Jülich GmbH, Tallinn University, Universität Regensburg (REGENSBURG), Universität Regensburg, School of Social Sciences [Cardiff], Cardiff University, Estonian University of Life Sciences (EMU), Sch Life Sci Weihenstephan, Arizona State University [Tempe] (ASU), Department of Forest Resources, University of Minnesota System-University of Minnesota System, Research Institute for Networks and Communications Engineering (RINCE), Dublin City University [Dublin] (DCU)-Science Foundation Ireland-Enterprise Ireland-Higher Education Authority-School of Electronic Engineering, Southwest University of Science and Technology [Mianyang] (SWUST), Universidade Federal do Acre (UFAC), Berlin-Brandenburg Institute of Advanced Biodiversity Research (BBIB), Centre méditérannéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Mississippi State University [Mississippi], University of Southampton, Yale University [New Haven], Brookhaven National Laboratory [Upton, NY] (BNL), UT-Battelle, LLC-Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY)-U.S. Department of Energy [Washington] (DOE), East Stroudsburg University, INDEHESA, Forestry School, Universidad de Extremadura - University of Extremadura (UEX), Institute of Physical Geography [Frankfurt am Main], Universität Zürich [Zürich] = University of Zurich (UZH), Lake Ecosystems Group [Lancaster, U.K.] (Centre for Ecology & Hydrology), Lancaster Environment Centre [Lancaster, U.K.], University of Valladolid, Norwegian Institute for Nature Research (NINA), Universidad Nacional de Colombia [Bogotà] (UNAL), Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA), Universidade de Coimbra [Coimbra], Algoma University, Senckenberg biodiversität und klima forschungszentrum (BIK-F), Forschungsinstitut Senckenberg (SGN), University of Nottingham, UK (UON), University of Würzburg = Universität Würzburg, Agence Française de Sécurité Sanitaire des Aliments (AFSSA), Herencia, Kirstenbosch Research Centre, South African National Biodiversity Institute, Federal University of Pernambuco [Recife], Sharplex Services, University of Hohenheim, Komarov Botanical Institute RAS, Center for Sustainability Science, Hokkaido, Département de Biologie, University of Regina (UR), Technische Universität Ilmenau (TU ), Universidade de Lisboa = University of Lisbon (ULISBOA), Universidade Federal de Lavras = Federal University of Lavras (UFLA), Università degli Studi di Padova = University of Padua (Unipd), Gothenburg Global Biodiversity Centre, Department of Biology [Gainesville] (UF|Biology), Texas Tech University [Lubbock] (TTU), Florida Museum of Natural History [Gainesville], KU Leuven, Embrapa Recursos Genéticos e Biotecnologia [Brasília], Universiteit Leiden, University of California [Riverside] (UC Riverside), Pacific Northwest National Laboratory (PNNL), University of Natural Resources and Applied Life Sciences, Vienna, (BOKU) and Competence Centre Wood K plus, University of Novi Sad, Instituto Nacional de Investigaciones en Biodiversidad y Medioambiente [Bariloche] (INIBIOMA-CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad Nacional del Comahue [Neuquén] (UNCOMA), Slovak Academy of Sciences (SAS), Technical University in Zvolen (TUZVO), Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague (CZU), University of Aberdeen, University of Maryland System, Universität Innsbruck [Innsbruck], Estacion Experimental de Zonas Aridas, Hacettepe University = Hacettepe Üniversitesi, Centre for Forest Research (CFR), Université du Québec à Montréal = University of Québec in Montréal (UQAM), Bioversity International [Montpellier], Bioversity International [Rome], Consultative Group on International Agricultural Research [CGIAR] (CGIAR)-Consultative Group on International Agricultural Research [CGIAR] (CGIAR), Department of Animal and Plant Sciences [Sheffield], University of Sheffield [Sheffield], The School for Field Studies, Quantum Optics and Laser Science, Blackett Laboratory, Blackett Laboratory, Imperial College London-Imperial College London, University of Delaware [Newark], Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Biodiversity and Ecosystem Services Research Group, Stellenbosch University, Czech University of Life Science, Aristotle University of Thessaloniki, Osaka Natural History Center, Ural State Forest Engineering University, University of New Hampshire (UNH), University of Calgary, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Hawkesbury Institute for the Environment [Richmond] (HIE), Computational & Applied Vegetation Ecology (CAVElab), Dept Forest & Water Management, Lab Forestry, Museu Paraense Emílio Goeldi, Federal University of Para - Universidade Federal do Pará - UFPA [Belém, Brazil] (UFPA), State Key Laboratory of Natural and Biomimetic Drugs, Fudan University [Shanghai], Department of Ecological Science [Amsterdam], Vrije Universiteit Brussel (VUB), Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), Université d'Orléans (UO)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Biology, Free University of Bozen-Bolzano, Dpt Biological Sciences, Macquarie University, Duke University [Durham], IFP Energies nouvelles (IFPEN), Department of Primary Industries, Graduate School of Integrated Arts and Sciences, Hiroshima University, Université de Tsukuba = University of Tsukuba, SUNY College of Environmental Science and Forestry (SUNY-ESF), Biological Sciences Department (BIOLOGICAL SCIENCES DEPARTMENT), Nanjing University (NJU), National Taiwan University [Taiwan] (NTU), Zhejiang University, Beijing Forestry University, Institut National Polytechnique Félix Houphouët-Boigny, Universität Leipzig, Max Planck Fellow Program for Christian Wirth, the International Programme of Biodiversity Science (DIVERSITAS), the International Geosphere‐Biosphere Programme (IGBP), Future Earth, the French Foundation for Biodiversity Research (FRB), and GIS ‘Climat, Environnement et Société’ France, JENS KATTGE, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, GERMANY, ELLEN L. FRY, UNIVERSITY OF LIÈGE, BELGIUM, NIKOLAOS M. FYLLAS, UNIVERSITY OF THE AEGEAN, GREECE, GERHARD BÖNISCH, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, GERMANY, SUSANNE TAUTENHAHN, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, JENA, GERMANY, GIJSBERT D. A. WERNER, UNIVERSITY OF OXFORD, OXFORD, UK, TUOMAS AAKALA, UNIVERSITY OF HELSINKI, FINLAND, MEHDI ABEDI, TARBIAT MODARES UNIVERSITY, IRAN, ALICIA T. R. ACOSTA, UNIVERSITY OF ROMA TRE, ITALY, GEORGE C. ADAMIDIS, UNIVERSITY OF BERN, SWITZERLAND, KAIRI ADAMSON, UNIVERSITY OF TARTU, ESTONIA, MASAHIRO AIBA, TOHOKU UNIVERSITY, JAPAN., CÉCILE H. ALBERT, AIX MARSEILLE UNIV, UNIV AVIGNON, FRANCE., JULIO M. ALCÁNTARA, UNIVERSIDAD DE JAÉN, SPAIN, CAROLINA ALCÁZAR C, Instituto Alexander Von Humboldt, Colombia., HAMADA ALI, SUEZ CANAL UNIVERSITY, EGYPT, BERNARD AMIAUD, UNIVERSITÉ DE LORRAINE, FRANCE., CHRISTIAN AMMER, UNIVERSITY OF GÖTTINGEN, GERMANY, MARIANO M. AMOROSO, UNIVERSIDAD NACIONAL DE RÍO NEGRO, ARGENTINA, MADHUR ANAND, UNIVERSITY OF GUELPH, CANADA., MARIJN BAUTERS, GHENT UNIVERSITY, BELGIUM., ERIKA BAZZATO, UNIVERSITY OF CAGLIARI, ITALY., MICHAEL BECKMANN, Helmholtz Centre for Environmental Research, Germany., HANS BEECKMAN, ROYAL MUSEUM FOR CENTRAL AFRICA, BELGIUM., CARL BEIERKUHNLEIN, UNIVERSITY OF BAYREUTH, GERMANY., RENEE BEKKER, UNIVERSITY OF GRONINGEN, THE NETHERLANDS., JOANA BERGMANN, FREIE UNIVERSITÄT BERLIN, GERMANY., MARCOS BERGMANN CARLUCCI, UFPC, LOGAN BERNER, NORTHERN ARIZONA UNIVERSITY, USA., MARKUS BERNHARDT-RÖMERMANN, FRIEDRICH SCHILLER UNIVERSITY JENA, GERMANY., CHRISTOF BIGLER, ETH ZURICH, SWITZERLAND., FEDERICO BRUMNICH, UNIVERSIDAD NACIONAL DEL LITORAL (FICH-UNL), ARGENTINA, HANS HENRIK BRUUN, UNIVERSITY OF COPENHAGEN, DENMARK, DAVID BRUY, UNIVERSITÉ DE MONTPELLIER, FRANCE, SERRA W. BUCHANAN, UNIVERSITY OF TORONTO SCARBOROUGH, CANADA, ROBERT BUITENWERF, AARHUS UNIVERSITY, DENMARK, DANIEL E. BUNKER, NEW JERSEY INSTITUTE OF TECHNOLOGY, USA, JANA BÜRGER, UNIVERSITY OF ROSTOCK, GERMANY, SABINA BURRASCANO, SAPIENZA UNIVERSITY OF ROME, ITALY, DAVID F. R. P. BURSLEM, UNIVERSITY OF ABERDEEN, UK, BRADLEY J. BUTTERFIELD, NORTHERN ARIZONA UNIVERSITY, USA, CHAEHO BYUN, YONSEI UNIVERSITY, KOREA, MARINA C. SCALON, UFP, MARCO CACCIANIGA, UNIVERSITÀ DEGLI STUDI DI MILANO, ITALY, MARC CADOTTE, UNIVERSITY OF TORONTO SCARBOROUGH, CANADA, MAXIME CAILLERET, AIX?MARSEILLE UNIVERSITY, FRANCE, JAMES CAMAC, THE UNIVERSITY OF MELBOURNE, AUSTRALIA, JESÚS JULIO CAMARERO, INSTITUTO PIRENAICO DE ECOLOGÍA (IPE?CSIC), SPAIN, COURTNEY CAMPANY, COLGATE UNIVERSITY, USA, GIANDIEGO CAMPETELLA, UNIVERSITY OF CAMERINO, ITALY, JUAN ANTONIO CAMPOS, UNIVERSITY OF THE BASQUE COUNTRY UPV/EHU, SPAIN, LAURA CANO-ARBOLEDA, UNIVERSIDAD NACIONAL DE COLOMBIA, COLOMBIA, ROBERTO CANULLO, UNIVERSITY OF CAMERINO, ITALY, MICHELE CARBOGNANI, UNIVERSITY OF PARMA, ITALY, FABIO CARVALHO, LANCASTER UNIVERSITY, UK, BASTIEN CASTAGNEYROL, UNIV. BORDEAUX, FRANCE, JANE A. CATFORD, KING'S COLLEGE LONDON, UK, JEANNINE CAVENDER-BARES, UNIVERSITY OF MINNESOTA, USA, BRUNO E. L. CERABOLINI, UNIVERSITY OF INSUBRIA, ITALY, MARCO CERVELLINI, UNIVERSITY OF BOLOGNA, ITALY, EDUARDO CHACÓN-MADRIGAL, UNIVERSIDAD DE COSTA RICA, COSTA RICA, KENNETH CHAPIN, THE UNIVERSITY OF ARIZONA, USA, SAMANTHA DAWSON, SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES, AREND JACOBUS DE BEER, UNIVERSITY OF PRETORIA, SOUTH AFRICA, ANGEL DE FRUTOS, HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH, GERMANY, LEANDRO DUARTE, UFRGS, EMILIE DUCOURET, UMR ECOFOG (AGROPARISTECH, CNRS, INRA, UNIVERSITÉ DES ANTILLES, UNIVERSITÉ DE LA GUYANE), FRANCE, STEFAN DULLINGER, UNIVERSITY OF VIENNA, AUSTRIA, DAN F. B. FLYNN, ARNOLD ARBORETUM OF HARVARD UNIVERSITY, USA, VERONIKA FONTANA, INSTITUTE FOR ALPINE ENVIRONMENT, ITALY, KYONG-SOOK CHUNG, JUNGWON UNIVERSITY, KOREA, MILAN CHYTRÝ, MASARYK UNIVERSITY, CZECH REPUBLIC, DANIELA CICCARELLI, UNIVERSITY OF PISA, ITALY, LLUÍS COLL, UNIVERSITY OF LLEIDA, SPAIN, COURTNEY G. COLLINS, UNIVERSITY OF CALIFORNIA RIVERSIDE, USA, LUISA CONTI, UNIVERSITY OF LIFE SCIENCES PRAGUE, CZECH REPUBLIC, DAVID COOMES, UNIVERSITY OF CAMBRIDGE, UK, JOHANNES H. C. CORNELISSEN, VRIJE UNIVERSITEIT, THE NETHERLANDS, WILLIAM K. CORNWELL, EARTH AND ENVIRONMENTAL SCIENCES, AUSTRALIA, PIERMARIA CORONA, CREA – RESEARCH CENTRE FOR FORESTRY AND WOOD, ITALY, MARIE COYEA, UNIVERSITÉ LAVAL, CANADA, JOSEPH CRAINE, JONAH VENTURES, USA, DYLAN CRAVEN, UNIVERSIDAD MAYOR, CHILE, JORIS P. G. M. CROMSIGT, SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES, SWEDEN, ANIKÓ CSECSERITS, MTA CENTRE FOR ECOLOGICAL RESEARCH, HUNGARY, KATARINA CUFAR, UNIVERSITY OF LJUBLJANA, SLOVENIA, MATTHIAS CUNTZ, UNIVERSITÉ DE LORRAINE, FRANCE, ANA CAROLINA DA SILVA, SANTA CATARINA STATE UNIVERSITY, BRAZIL, KYLA M. DAHLIN, MICHIGAN STATE UNIVERSITY, USA, MATTEO DAINESE, INSTITUTE FOR ALPINE ENVIRONMENT, ITALY, IGOR DALKE, INSTITUTE OF BIOLOGY OF KOMI SCIENCE CENTRE OF THE URAL BRANCH OF THE RUSSIAN ACADEMY OF SCIENCES, RUSSIA, MICHELE DALLE FRATTE, UNIVERSITY OF INSUBRIA, ITALY, ANH TUAN DANG-LE, UNIVERSITY HO CHI MINH CITY, VIETNAM, JIRÍ DANIHELKA, MASARYK UNIVERSITY, CZECH REPUBLIC, MASAKO DANNOURA, KYOTO UNIVERSITY, JAPAN, JONATHAN R. DE LONG, NETHERLANDS INSTITUTE OF ECOLOGY, THE NETHERLANDS, BENJAMIN DECHANT, SEOUL NATIONAL UNIVERSITY, REPUBLIC OF KOREA, SYLVAIN DELAGRANGE, INSTITUTE OF TEMPERATE FOREST SCIENCES (ISFORT), CANADA, NICOLAS DELPIERRE, UNIVERSITY OF PARIS?SUD, FRANCE, GÉRALDINE DERROIRE, UNIVERSITÉ DES ANTILLES, FRANCE, ARILDO S. DIAS, UNIVERSITÄT FRANKFURT, GERMANY, MILTON HUGO DIAZ-TORIBIO, UNIVERSITY OF FLORIDA, USA, PANAYIOTIS G. DIMITRAKOPOULOS, UNIVERSITY OF THE AEGEAN, GREECE, MARK DOBROWOLSKI, THE UNIVERSITY OF WESTERN AUSTRALIA, AUSTRALIA, DANIEL DOKTOR, HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH – UFZ, GERMANY, PAVEL DREVOJAN, MASARYK UNIVERSITY, CZECH REPUBLIC, NING DONG, MACQUARIE UNIVERSITY, AUSTRALIA, JOHN DRANSFIELD, ROYAL BOTANIC GARDENS KEW, UK, STEFAN DRESSLER, DEPARTMENT OF BOTANY AND MOLECULAR EVOLUTION, GERMANY, WALTER DURKA, GERMAN CENTER FOR INTEGRATIVE BIODIVERSITY RESEARCH (IDIV) HALLE?JENA?LEIPZIG, GERMANY, REMKO DUURSMA, WESTERN SYDNEY UNIVERSITY, AUSTRALIA, OLGA DYMOVA, KOMI REPUBLIC, RUSSIA, E-VOJTKÓ, A., UNIVERSITY OF SOUTH BOHEMIA, CZECH REPUBLIC, ROLF LUTZ ECKSTEIN, KARLSTAD UNIVERSITY, SWEDEN, HAMID EJTEHADI, FERDOWSI UNIVERSITY OF MASHHAD, IRAN, JAMES ELSER, UNIVERSITY OF MONTANA, USA, THAISE EMILIO, UNIVERSITY OF CAMPINAS UNICAMP, BRAZIL, KRISTINE ENGEMANN, AARHUS UNIVERSITY, DENMARK, MOHAMMAD BAGHER ERFANIAN, FERDOWSI UNIVERSITY OF MASHHAD, IRAN, ALEXANDRA ERFMEIER, KIEL UNIVERSITY, KIEL, GERMANY, ADRIANE ESQUIVEL-MUELBERT, EARTH AND ENVIRONMENTAL SCIENCES, AUSTRALIA, GERD ESSER, JUSTUS LIEBIG UNIVERSITY, GERMANY, MARC ESTIARTE, SPANISH NATIONAL RESEARCH COUNCIL – CSIC, SPAIN, TOMAS F. DOMINGUES, DEPARTMENT OF BIOLOGY – FFCLRP/USP, BRAZIL, WILLIAM F. FAGAN, UNIVERSITY OF MARYLAND, USA, JAIME FAGÚNDEZ, UNIVERSITY OF A CORUÑA, SPAIN, DANIEL S. FALSTER, EVOLUTION & ECOLOGY RESEARCH CENTRE, AUSTRALIA, YING FAN, RUTGERS UNIVERSITY, USA, JINGYUN FANG, PEKING UNIVERSITY, CHINA, EMMANUELE FARRIS, UNIVERSITY OF SASSARI, ITALY, FATIH FAZLIOGLU, ORDU UNIVERSITY, TURKEY, YANHAO FENG, LANZHOU UNIVERSITY, CHINA, FERNANDO FERNANDEZ-MENDEZ, UNIVERSIDAD DEL TOLIMA, COLOMBIA, CARLOTTA FERRARA, CREA – RESEARCH CENTRE FOR FORESTRY AND WOOD, ITALY, JOICE NUNES FERREIRA, CPATU, ALESSANDRA FIDELIS, (UNESP), RIO CLARO, BRAZIL, BRYAN FINEGAN, CATIE-CENTRO AGRONÓMICO TROPICAL DE INVESTIGACIÓN Y ENSEÑANZA, COSTA RICA, JENNIFER FIRN, QUEENSLAND UNIVERSITY OF TECHNOLOGY (QUT), AUSTRALIA, TIMOTHY J. FLOWERS, UNIVERSITY OF SUSSEX, UK, ESTELLE FOREY, UNIVERSITÉ DE ROUEN, FRANCE, CRISTIANE FORGIARINI, UFRGS, BRAZIL., LOUIS FRANÇOIS, UNIVERSITY OF LIÈGE, BELGIUM., MARCELO FRANGIPANI, UFRGS, BRAZIL, DOROTHEA FRANK, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, GERMANY, CEDRIC FRENETTE-DUSSAULT, GÉOPOLE DE L'UNIVERSITÉ DE SHERBROOKE, CANADA, GRÉGOIRE T. FRESCHET, PAUL SABATIER UNIVERSITY TOULOUSE, FRANCE, PAUL LEADLEY, UNIVERSITY OF PARIS-SUD, UNIVERSITÉ PARIS-SACLAY, ORSAY, FRANCE, IZABELA ALEIXO, NATIONAL INSTITUTE OF AMAZONIAN RESEARCH (INPA), BRAZIL, SANDRA DÍAZ, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, SANDRA LAVOREL, UNIV. SAVOIE MONT BLANC, LECA, GRENOBLE, FRANCE, IAIN COLIN PRENTICE, IMPERIAL COLLEGE, UK., CAROLYN ANDERSON, UNIVERSITY OF MASSACHUSETTS AMHERST, USA, NIELS ANTEN, WAGENINGEN UNIVERSITY, THE NETHERLANDS, JOSEPH ANTOS, UNIVERSITY OF VICTORIA, CANADA, DEBORAH MATTOS GUIMARÃES APGAUA, JAMES COOK UNIVERSITY, AUSTRALIA, TIA-LYNN ASHMAN, UNIVERSITY OF PITTSBURGH, USA, DEGI HARJA ASMARA, UNIVERSITÉ LAVAL, CANADA, GREGORY P. ASNER, ARIZONA STATE UNIVERSITY, USA., MICHAEL ASPINWALL, UNIVERSITY OF NORTH FLORIDA, USA., OWEN ATKIN, AUSTRALIAN NATIONAL UNIVERSITY, AUSTRALIA., ISABELLE AUBIN, NATURAL RESOURCES CANADA, LARS BAASTRUP-SPOHR, UNIVERSITY OF COPENHAGEN, DENMARK., KHADIJEH BAHALKEH, TARBIAT MODARES UNIVERSITY, IRAN., MICHAEL BAHN, UNIVERSITY OF INNSBRUCK, AUSTRIA., TIMOTHY BAKER, UNIVERSITY OF LEEDS, LEEDS, UK., WILLIAM J. BAKER, ROYAL BOTANIC GARDENS KEW, UK., JAN P. BAKKER, UNIVERSITY OF GRONINGEN, THE NETHERLANDS., DENNIS BALDOCCHI, UNIVERSITY OF CALIFORNIA BERKELEY, USA., JENNIFER BALTZER, WILFRID LAURIER UNIVERSITY, CANADA, ARINDAM BANERJEE, UNIVERSITY OF MINNESOTA, USA., ANNE BARANGER, AGROPARISTECH, FRANCE., JOS BARLOW, LANCASTER UNIVERSITY, UK., DIEGO R. BARNECHE, UNIVERSITY OF EXETER, UK., ZDRAVKO BARUCH, THE UNIVERSITY OF ADELAIDE, AUSTRALIA., DENIS BASTIANELLI, UNIV MONTPELLIER, FRANCE., JOHN BATTLES, UNIVERSITY OF CALIFORNIA AT BERKELEY, USA, WILLIAM BAUERLE, COLORADO STATE UNIVERSITY, USA, SOLVEIG FRANZISKA BUCHER, FRIEDRICH?SCHILLER?UNIVERSITÄT JENA, GERMANY, GAVIN BELFRY, UNIVERSITY OF TENNESSEE, USA., MICHAEL BELLUAU, UNIVERSITÉ DU QUÉBEC À MONTRÉAL, CANADA., MIRELA BELOIU, UNIVERSITY OF BAYREUTH, GERMANY., RAQUEL BENAVIDES, MUSEO NACIONAL DE CIENCIAS NATURALES-CSIC, SPAIN., LAHCEN BENOMAR, UNIVERSITÉ LAVAL, CANADA., MARY LEE BERDUGO-LATTKE, UNIVERSIDAD NACIONAL DE COLOMBIA, COLOMBIA., ERIKA BERENGUER, UNIVERSITY OF OXFORD, UK., RODRIGO BERGAMIN, UFRS, NINA BUCHMANN, ETH ZURICH, ZURICH, SWITZERLAND, ANNE D. BJORKMAN, UNIVERSITY OF GOTHENBURG, SWEDEN., CHRIS BLACKMAN, UNIVERSITÉ CLERMONT-AUVERGNE, FRANCE., CAROLINA BLANCO, UFRGS, BENJAMIN BLONDER, ARIZONA STATE UNIVERSITY, USA., DANA BLUMENTHAL, USDA-ARS RANGELAND RESOURCES & SYSTEMS RESEARCH UNIT, USA., KELLY T. BOCANEGRA-GONZÁLEZ, UNIVERSIDAD DEL TOLIMA, COLOMBIA., PASCAL BOECKX, GHENT UNIVERSITY, BELGIUM., STEPHANIE BOHLMAN, UNIVERSITY OF FLORIDA, USA., KATRIN BÖHNING-GAESE, UNIVERSITÄT FRANKFURT, GERMANY., LAURA BOISVERT-MARSH, UNIVERSITÄT FRANKFURT, GERMANY., WILLIAM BOND, UNIVERSITY OF CAPE TOWN, SOUTH AFRICA., BEN BOND-LAMBERTY, COLLEGE PARK, USA., ARNOUD BOOM, UNIVERSITY OF LEICESTER, UK., COLINE C. F. BOONMAN, RADBOUD UNIVERSITY, THE NETHERLANDS., KAUANE BORDIN, UFRGS, ELIZABETH H. BOUGHTON, ARCHBOLD BIOLOGICAL STATION'S BUCK ISLAND RANCH, USA., VANESSA BOUKILI, UNIVERSITY OF CONNECTICUT, USA, DAVID M. J. S. BOWMAN, UNIVERSITY OF TASMANIA, AUSTRALIA., SANDRA BRAVO, UNIVERSIDAD NACIONAL DE SANTIAGO DEL ESTERO, MARCO RICHARD BRENDEL, UNIVERSITY OF HOHENHEIM, MARTIN R. BROADLEY, UNIVERSITY OF NOTTINGHAM, UK, KERRY A. BROWN, KINGSTON UNIVERSITY, UK., HELGE BRUELHEIDE, MARTIN LUTHER UNIVERSITY HALLE?WITTENBERG, GERMANY, FERNANDO CASANOVES, CATIE-CENTRO AGRONÓMICO TROPICAL DE INVESTIGACIÓN Y ENSEÑANZA, COSTA RICA, F. STUART CHAPIN, UNIVERSITY OF ALASKA FAIRBANKS, USA, STEFANO CHELLI, UNIVERSITY OF CAMERINO, ITALY, SI?CHONG CHEN, ROYAL BOTANIC GARDENS, UK, ANPING CHEN, COLORADO STATE UNIVERSITY, USA, PAOLO CHERUBINI, UNIVERSITY OF BRITISH COLUMBIA, CANADA, FRANCESCO CHIANUCCI, CREA – RESEARCH CENTRE FOR FORESTRY AND WOOD, ITALY, BRENDAN CHOAT, WESTERN SYDNEY UNIVERSITY, AUSTRALIA, GUILHERME G. MAZZOCHINI, UNIVERSITY OF CAMPINAS, CAMPINAS, BRAZIL, SOPHIE GACHET, UNIV AVIGNON, FRANCE, RACHAEL GALLAGHER, MACQUARIE UNIVERSITY, AUSTRALIA, GISLENE GANADE, UFRN, BRAZIL., MARY-CLAIRE GLASENHARDT, THE MORTON ARBORETUM, USA, ALAIN HAMBUCKERS, UNIVERSITY OF LIÈGE, BELGIUM, MASAE ISHIHARA, KYOTO UNIVERSITY, JAPAN, LEONID IVANOV, TYUMEN STATE UNIVERSITY, RUSSIA, LARISSA IVANOVA, TYUMEN STATE UNIVERSITY, RUSSIA., COLLEEN M. IVERSEN, OAK RIDGE NATIONAL LABORATORY, USA, JORDI IZQUIERDO, Universitat Politècnica de Catalunya, Spain, ROBERT B. JACKSON, STANFORD UNIVERSITY, USA, FRANCESCA GANGA, UNIVERSITY OF CAGLIARI, ITALY, PABLO GARCÍA-PALACIOS, UNIVERSIDAD REY JUAN CARLOS, SPAIN, VERÓNICA GARGAGLIONE, UNIVERSIDAD NACIONAL DE LA PATAGONIA AUSTRAL, ARGENTINA, ERIC GARNIER, UNIV. MONTPELLIER, FRANCE, JOSE LUIS GARRIDO, ESTACIÓN EXPERIMENTAL DEL ZAIDÍN, SPAIN, ANDRÉ LUÍS DE GASPER, UNIVERSIDADE REGIONAL DE BLUMENAU, BRAZIL, GUILLERMO GEAIZQUIERDO, INIA?CIFOR, SPAIN, DAVID GIBSON, SOUTHERN ILLINOIS UNIVERSITY CARBONDALE, USA, ANDREW N. GILLISON, CENTER FOR BIODIVERSITY MANAGEMENT, AUSTRALIA, AELTON GIROLDO, INSTITUTO FEDERAL DE EDUCAÇÃO CIÊNCIA E TECNOLOGIA DO CEARÁ, BRAZIL, SEAN GLEASON, WATER MANAGEMENT AND SYSTEMS RESEARCH UNIT, USA, MARIANA GLIESCH, INSTITUTE OF INTEGRATIVE BIOLOGY, SWITZERLAND, EMMA GOLDBERG, UNIVERSITY OF MINNESOTA, USA, BASTIAN GÖLDEL, AARHUS UNIVERSITY, DENMARK, ERIKA GONZALEZ-AKRE, NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY NTNU, NORWAY, JOSE L. GONZALEZ-ANDUJAR, CSIC-INSTITUTE FOR SUSTAINABLE AGRICULTURE (IAS), SPAIN, ANDRÉS GONZÁLEZ-MELO, UNIVERSIDAD DEL ROSARIO, COLOMBIA, ANA GONZÁLEZ-ROBLES, UNIVERSIDAD DE JAÉN, SPAIN, BENTE JESSEN GRAAE, NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY NTNU, NORWAY, ELENA GRANDA, UNIVERSITY OF ALCALÁ, SPAIN, SARAH GRAVES, UNIVERSITY OF FLORIDA, USA, WALTON A. GREEN, HARVARD UNIVERSITY, USA, THOMAS GREGOR, SENCKENBERG RESEARCH INSTITUTE AND NATURAL HISTORY MUSEUM, GERMANY, NICOLAS GROSS, UNIVERSIDAD REY JUAN CARLOS, SPAIN, GREG R. GUERIN, THE UNIVERSITY OF ADELAIDE, AUSTRALIA, ANGELA GÜNTHER, MAX PLANCK INSTITUTE FOR BIOGEOCHEMISTRY, GERMANY, ALVARO G. GUTIÉRREZ, UNIVERSIDAD DE CHILE, CHILE, LILLIE HADDOCK, COLLEGE PARK, USA, ANNA HAINES, THE UNIVERSITY OF MANCHESTER, UK, JEFFERSON HALL, SMITHSONIAN TROPICAL RESEARCH INSTITUTE, REPUBLIC OF PANAMA, WENXUAN HAN, CHINA AGRICULTURAL UNIVERSITY, CHINA, SANDY P. HARRISON, UNIVERSITY OF READING, UK, WESLEY HATTINGH, UNIVERSITY OF THE WITWATERSRAND, SOUTH AFRICA, JOSEPH E. HAWES, ANGLIA RUSKIN UNIVERSITY, UK, TIANHUA HE, CURTIN UNIVERSITY, AUSTRALIA, PENGCHENG HE, CHINESE ACADEMY OF SCIENCES, CHINA, JACOB MASON HEBERLING, CARNEGIE MUSEUM OF NATURAL HISTORY, USA, AVELIINA HELM, UNIVERSITY OF TARTU, ESTONIA, STEFAN HEMPEL, FREIE UNIVERSITÄT BERLIN, GERMANY, JÖRN HENTSCHEL, FRIEDRICH-SCHILLER-UNIVERSITÄT JENA, GERMANY, BRUNO HÉRAULT, UNIVERSITÉ DE MONTPELLIER, FRANCE, ANA-MARIA HERE, TRANSILVANIA UNIVERSITY OF BRASOV, ROMANIA, KATHARINA HERZ, MARTIN LUTHER UNIVERSITY HALLE?WITTENBERG, GERMANY, MYRIAM HEUERTZ, UNIV. BORDEAUX, FRANCE, THOMAS HICKLER, GOETHE UNIVERSITY, GERMANY, PETER HIETZ, UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES, AUSTRIA, PEDRO HIGUCHI, SANTA CATARINA STATE UNIVERSITY, BRAZIL, ANDREW L. HIPP, THE MORTON ARBORETUM, USA, ANDREW HIRONS, UNIVERSITY CENTRE MYERSCOUGH, UK, MARIA HOCK, INSTITUTE FOR ECOSYSTEM RESEARCH/GEOBOTANY, GERMANY, JAMES AARON HOGAN, FLORIDA INTERNATIONAL UNIVERSITY, USA, KAREN HOLL, UNIVERSITY OF CALIFORNIA, USA, OLIVIER HONNAY, PLANT CONSERVATION AND POPULATION BIOLOGY, BELGIUM, KNUT ANDERS HOVSTAD, DEPARTMENT OF LANDSCAPE AND BIODIVERSITY, NORWAY, TOMOAKI ICHIE, KOCHI UNIVERSITY, JAPAN, BORIS IGIC, UNIVERSITY OF ILLINOIS AT CHICAGO, USA, ESTELA ILLA, UNIVERSITAT DE BARCELONA, SPAIN, MARNEY ISAAC, UNIVERSITY OF TORONTO, CANADA, BENJAMIN JACKSON, UNIVERSITY OF EDINBURGH, SCOTLAND, HERVÉ JACTEL, UNIV. BORDEAUX, FRANCE, ANDRZEJ M. JAGODZINSKI, UNIVERSITY OF LIFE SCIENCES, POLAND, UTE JANDT, MARTIN LUTHER UNIVERSITY HALLE-WITTENBERG, GERMANY, STEVEN JANSEN, ULM UNIVERSITY, GERMANY, THOMAS, University of Oxford [Oxford], University of Helsinki, Tarbiat Modaras University, Roma Tre University, Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL)-Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL), Centre for Biodiversity and Sustainable Land-use, University of Göttingen, Göttingen, Germany, Department of Biology, University of North Florida, Jacksonville, FL, USA, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Department of Range Management, Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University, Noor, Iran, University of Innsbruck, School of Geography, University of Leeds, Leeds, UK, Centre for Ecology and Conservation, College of Life and Environmental Sciences, University of Exeter, Penryn, UK., School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of California at Berkeley, Berkeley, CA, USA, Department of Green Chemistry and Technology, Ghent University, Gent, Belgium, Department of Environment, Ghent University, Gent, Belgium, Department of Life and Environmental Sciences, Botany Division, University of Cagliari, Cagliari, Italy, Museo Nacional de Ciencias Naturales-CSIC, Madrid, Spain, Environmental Change Institute, University of Oxford, Oxford, UK, Institut für Biologie, Freie Universität Berlin, Berlin, Germany, Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg, Sweden, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, Universiteit Gent = Ghent University [Belgium] (UGENT), School of Geography, Geology and Environment, University of Leicester, Leicester, UK, Institute of Landscape and Plant Ecology, University of Hohenheim, Stuttgart, Germany, Institute of Biology/Geobotany and Botanical Garden, Martin Luther University Halle-Wittenberg, Halle, Germany, German Center for Integrative Biodiversity Research (iDiv) Halle-Jena- Leipzig, Leipzig, Germany, University of Toronto [Scarborough, Canada], Faculty of Agricultural and Environmental Sciences, University of Rostock, Rostock, Germany, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy, Department of Plant Biology and Ecology, University of the Basque Country UPV/ EHU, Bilbao, Spain, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy, BIGEA, Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum – University of Bologna, Bologna, Italy, Escuela de Biología, Universidad de Costa Rica, San José, Costa Rica, The University of Arizona, Tucson, AZ, USA, University of Alaska [Anchorage], Royal Botanic Gardens, Kew, Department of Biology, University of Pisa, Pisa, Italy, Department of Plant Sciences, University of Cambridge, Cambridge, UK, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia, Institut National de la Recherche Agronomique (INRA)-Université de Lorraine (UL)-AgroParisTech, Department of Plant and Soil Sciences, University of Pretoria, Pretoria, South Africa, Department of Landscape Architecture and Rural Systems Engineering, Seoul National University, Seoul, Republic of Korea, Department of Botany and Biodiversity Research, University of Vienna, Department of Environmental and Life Sciences – Biology, Karlstad University, Quantitative Plant Ecology and Biodiversity Research Laboratory, Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Justus Liebig University, Justus-Liebig-Universität Gießen (JLU), University of Sassari, Consiglio per la Ricerca in Agricoltura e l’analisi dell’economia agraria (CREA), Universidade de São Paulo (USP), Harvard University [Cambridge], Federal University of Rio Grande do Sul, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Université Paul-Valéry - Montpellier 3 (UPVM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), University of Campinas [Campinas] (UNICAMP), University of Cagliari, Universidad de Chile, University of Natural Resources and Life Sciences (BOKU), University of California, Norwegian Institute of Bioeconomy Research (NIBIO), Kyoto University [Kyoto], Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), University of Copenhagen = Københavns Universitet (KU), University of Venda, Philipps University of Marburg, Institut National de la Recherche Agronomique (INRA)-École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, State University of New York, Stonybrook, IT University of Copenhagen, Smithsonian Environmental Research Center, Humboldt University of Berlin, Georg-August-University [Göttingen], Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Nelson Mandela Metropolitan University [Port Elizabeth, South Africa], Netherlands Centre for Biodiversity Naturalis, University of Leipzig [Leipzig, Allemagne], Unité d'Agronomie, University of Debrecen-Research Centre for Molecular Medicine-Medical and Health Science Centre, Global Change Research Institute, University of California [Berkeley], Natural resources institute Finland, Universita degli Studi di Cagliari [Cagliari], Tel Aviv University [Tel Aviv], Oklahoma State University [Stillwater], Kyoto University [Kyoto]-Kyoto University [Kyoto], Universidade Estadual de Campinas (UNICAMP), Universidad Nacional Autónoma de México (UNAM), Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Universidad Autonoma de Madrid (UAM), University of Parma = Università degli studi di Parma [Parme, Italie], University of Milan, Forschungszentrum Juelich, Université Nice Sophia Antipolis (... - 2019) (UNS), U.S. Department of Energy [Washington] (DOE)-UT-Battelle, LLC-Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), University of Extremadura, University of Göttingen - Georg-August-Universität Göttingen, Universidade de Lisboa (ULISBOA), Federal University of Lavras, Universita degli Studi di Padova, Leiden University, University of California [Riverside] (UCR), Ferdowsi University of Mashhad, Museo Nacional de Ciencias Naturales (MNCN), Departments of Botany and Zoology, Federal University of Para - Universidade Federal do Para [Belem - Brésil], Institut National de la Recherche Agronomique (INRA)-Université d'Orléans (UO), Institut national polytechnique Félix Houphouët-Boigny, Universität Leipzig [Leipzig], Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA), Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto Multidisciplinario de Biología Vegetal (IMBIV), and Factulad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina, Laboratoire d'Ecologie Alpine (LECA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA), Imperial College London, London SW7 2AZ, UK., Department of Zoology, University of Oxford, Oxford, UK, Balliol College, University of Oxford, Oxford, UK, University of Roma Tre, Rome, Italy, Biodiversity Conservation Laboratory, Department of Environment, University of the Aegean, Mytilene, Greece, Institute of Ecology and Evolution, University of Bern, Bern, Switzerland, Tartu Observatory, University of Tartu, Tartumaa, Estonia, Graduate School of Life Sciences, Tohoku University, Sendai, Japan, Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU), Universidad de Jaén, Jaén, Spain, UMR Nancy-Université- INRA Agronomie et Environnement Nancy-Colmar, Nancy Université, Conicet-Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina, Environmental Sciences, Guelph, University of Massachusetts Amherst, Amherst, MA, USA, Wageningen University and Research Center (WUR), University of Victoria, Victoria, BC, Canada, Department of Ecology, University of Innsbruck, Innsbruck, Austria, Department of Biological Sciences-Lancaster University, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Helmholtz Centre for Environmental Research (UFZ), School of Informatics, Computing, and Cyber Systems, Northern Arizona University, Flagstaff, AZ, USA, Université Clermont Auvergne (UCA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universiteit Gent [Ghent], School of Forest Resources and Conservation, University of Florida, Gainesville, FL, USA, University of Tasmania, Hobart, Tas., Australia, AMAP, IRD, Herbier de Nouvelle-Calédonie, Nouméa, New Caledonia, Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Friedrich-Schiller-Universität Jena, Jena, Germany, Università degli Studi di Roma 'La Sapienza' [Rome], wiss Federal Institute for Forest, Snow and Landscape Research WSL, Birmensdorf, Switzerland, Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Tropical Agricultural Centre for Research and Higher Education (CATIE), Tropical Agricultural Centre for Research and Higher Education, Univ. Bordeaux, INRAE, BIOGECO, Cestas, France, Department of Ecology, Evolution, and Behavior, University of Minnesota, St. Paul, MN, USA, Royal Botanic Gardens, Kew, West Sussex, UK, Department of Biology, Colorado State University, Fort Collins, CO, USA, Hawkesbury Institute for the Environment, Western Sydney University, Sydney, NSW, Australia, Department of Botany and Zoology, Masaryk University, Brno, Czech Republic, Faculty of Environmental Sciences, University of Life Sciences Prague, Praha-Suchdol, Czech Republic, Institute of Botany, Czech Academy of Sciences, Třeboň, Czech Republic, Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden, MTA Centre for Ecological Research, Tihany, Hungary, Swedish Species Information Centre, Swedish University of Agricultural Sciences, Uppsala, Sweden, Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS)-Université de Guyane (UG)-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), University of Florida [Gainesville], UFZ - Helmholtz Centre for Environmental Research, School of Geography, Earth and Environmental Sciences – University of Birmingham, Universitat Autònoma de Barcelona [Barcelona] (UAB), University of Ordu, Council for Agricultural Research and Economics (CREA), Université de Sherbrooke [Sherbrooke], Université Paul-Valéry - Montpellier 3 (UM3)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), United States Department of Agriculture - USDA (USA), Smithsonian Institution, Carnegie Museum of Natural History, Friedrich-Schiller-Universität Jena, Biodiversité, Gènes et Communautés, Goethe-Universität Frankfurt am Main-Senckenberg Gesellschaft für Naturforschung, University of Natural Resources and Applied Life Sciences (BOKU), Florida International University (FIU), Université Catholique de Louvain (UCL), Stanford University [Stanford], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), University of Tasmania (UTAS), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure Agronomique de Toulouse-Institut National Polytechnique (Toulouse) (Toulouse INP), Charles University [Prague], Ghent University [Belgium] (UGENT), Helmholtz Zentrum für Umweltforschung (UFZ), Hokkaido University, Technical University of Munich (TUM), Wageningen University and Research Centre [Wageningen] (WUR), Georg-August-Universität Göttingen, Western Sydney University (UWS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département de Biologie, Université de Sherbrooke, Sherbrooke, QC, Canada, Université de Sherbrooke, Masaryk University, Czech Academy of Sciences [Prague] (ASCR), Natural Resources Institute Finland, Landcare Research [Lincoln], Université de Montréal [Montréal], Université Libre de Bruxelles [Bruxelles] (ULB), Centre National de la Recherche Scientifique (CNRS)-Ministère de l'Europe et des Affaires étrangères (MEAE), French Institute of Pondicherry (IFP), Normal Zhejiang University, Estonian University of Life Sciences, Institute of Biology Bucharest, Romanian Academy, VU University Amsterdam, Astronomical Institute of the Czech Academy of Sciences, Technische Universität München [München] (TUM), University of Parma, Cardiff School of Social Sciences, University of Cardiff, University of Minnesota [Twin Cities], Manaaki Whenua Landcare Research, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Brookhaven National Laboratory [Upton] (BNL), Stony Brook University [SUNY] (SBU), University of Zürich [Zürich] (UZH), Algoma University [Canada], University of Goettingen, University of Wuerzburg, University of Würzburg, AFSSA, Sherbrooke University, University of Lisbon, Department of Biology (University of Florida), Florida Museum of Natural History, Technical University in Zvolen, University of Zvolen, Fac Forestry & Wood Sci, Université du Québec à Montréal (UQAM), Bioversity International, Consultative Group on International Agricultural Research [CGIAR], Université Clermont Auvergne (UCA), Vrije Universiteit [Brussels] (VUB), University of Tsukuba, Kattge, Jen, Bönisch, Gerhard, Díaz, Sandra, Lavorel, Sandra, Prentice, Iain Colin, Leadley, Paul, Tautenhahn, Susanne, Werner, Gijsbert D A, Aakala, Tuoma, Abedi, Mehdi, Acosta, Alicia Teresa Rosario, Adamidis, George C, Adamson, Kairi, Aiba, Masahiro, Albert, Cécile H, Alcántara, Julio M, Alcázar C, Carolina, Aleixo, Izabela, Ali, Hamada, Amiaud, Bernard, Ammer, Christian, Amoroso, Mariano M, Anand, Madhur, Anderson, Carolyn, Anten, Niel, Antos, Joseph, Apgaua, Deborah Mattos Guimarãe, Ashman, Tia-Lynn, Asmara, Degi Harja, Asner, Gregory P, Aspinwall, Michael, Atkin, Owen, Aubin, Isabelle, Baastrup-Spohr, Lar, Bahalkeh, Khadijeh, Bahn, Michael, Baker, Timothy, Baker, William J, Bakker, Jan P, Baldocchi, Denni, Baltzer, Jennifer, Banerjee, Arindam, Baranger, Anne, Barlow, Jo, Barneche, Diego R, Baruch, Zdravko, Bastianelli, Deni, Battles, John, Bauerle, William, Bauters, Marijn, Bazzato, Erika, Beckmann, Michael, Beeckman, Han, Beierkuhnlein, Carl, Bekker, Renee, Belfry, Gavin, Belluau, Michael, Beloiu, Mirela, Benavides, Raquel, Benomar, Lahcen, Berdugo-Lattke, Mary Lee, Berenguer, Erika, Bergamin, Rodrigo, Bergmann, Joana, Bergmann Carlucci, Marco, Berner, Logan, Bernhardt-Römermann, Marku, Bigler, Christof, Bjorkman, Anne D, Blackman, Chri, Blanco, Carolina, Blonder, Benjamin, Blumenthal, Dana, Bocanegra-González, Kelly T, Boeckx, Pascal, Bohlman, Stephanie, Böhning-Gaese, Katrin, Boisvert-Marsh, Laura, Bond, William, Bond-Lamberty, Ben, Boom, Arnoud, Boonman, Coline C F, Bordin, Kauane, Boughton, Elizabeth H, Boukili, Vanessa, Bowman, David M J S, Bravo, Sandra, Brendel, Marco Richard, Broadley, Martin R, Brown, Kerry A, Bruelheide, Helge, Brumnich, Federico, Bruun, Hans Henrik, Bruy, David, Buchanan, Serra W, Bucher, Solveig Franziska, Buchmann, Nina, Buitenwerf, Robert, Bunker, Daniel E, Bürger, Jana, Burrascano, Sabina, Burslem, David F R P, Butterfield, Bradley J, Byun, Chaeho, Marques, Marcia, Scalon, Marina C, Caccianiga, Marco, Cadotte, Marc, Cailleret, Maxime, Camac, Jame, Camarero, Jesús Julio, Campany, Courtney, Campetella, Giandiego, Campos, Juan Antonio, Cano-Arboleda, Laura, Canullo, Roberto, Carbognani, Michele, Carvalho, Fabio, Casanoves, Fernando, Castagneyrol, Bastien, Catford, Jane A, Cavender-Bares, Jeannine, Cerabolini, Bruno E L, Cervellini, Marco, Chacón-Madrigal, Eduardo, Chapin, Kenneth, Chapin, F Stuart, Chelli, Stefano, Chen, Si-Chong, Chen, Anping, Cherubini, Paolo, Chianucci, Francesco, Choat, Brendan, Chung, Kyong-Sook, Chytrý, Milan, Ciccarelli, Daniela, Coll, Lluí, Collins, Courtney G, Conti, Luisa, Coomes, David, Cornelissen, Johannes H C, Cornwell, William K, Corona, Piermaria, Coyea, Marie, Craine, Joseph, Craven, Dylan, Cromsigt, Joris P G M, Csecserits, Anikó, Cufar, Katarina, Cuntz, Matthia, da Silva, Ana Carolina, Dahlin, Kyla M, Dainese, Matteo, Dalke, Igor, Dalle Fratte, Michele, Dang-Le, Anh Tuan, Danihelka, Jirí, Dannoura, Masako, Dawson, Samantha, de Beer, Arend Jacobu, De Frutos, Angel, De Long, Jonathan R, Dechant, Benjamin, Delagrange, Sylvain, Delpierre, Nicola, Derroire, Géraldine, Dias, Arildo S, Diaz-Toribio, Milton Hugo, Dimitrakopoulos, Panayiotis G, Dobrowolski, Mark, Doktor, Daniel, Dřevojan, Pavel, Dong, Ning, Dransfield, John, Dressler, Stefan, Duarte, Leandro, Ducouret, Emilie, Dullinger, Stefan, Durka, Walter, Duursma, Remko, Dymova, Olga, E-Vojtkó, Anna, Eckstein, Rolf Lutz, Ejtehadi, Hamid, Elser, Jame, Emilio, Thaise, Engemann, Kristine, Erfanian, Mohammad Bagher, Erfmeier, Alexandra, Esquivel-Muelbert, Adriane, Esser, Gerd, Estiarte, Marc, Domingues, Tomas F, Fagan, William F, Fagúndez, Jaime, Falster, Daniel S, Fan, Ying, Fang, Jingyun, Farris, Emmanuele, Fazlioglu, Fatih, Feng, Yanhao, Fernandez-Mendez, Fernando, Ferrara, Carlotta, Ferreira, Joice, Fidelis, Alessandra, Finegan, Bryan, Firn, Jennifer, Flowers, Timothy J, Flynn, Dan F B, Fontana, Veronika, Forey, Estelle, Forgiarini, Cristiane, François, Loui, Frangipani, Marcelo, Frank, Dorothea, Frenette-Dussault, Cedric, Freschet, Grégoire T, Fry, Ellen L, Fyllas, Nikolaos M, Mazzochini, Guilherme G, Gachet, Sophie, Gallagher, Rachael, Ganade, Gislene, Ganga, Francesca, García-Palacios, Pablo, Gargaglione, Verónica, Garnier, Eric, Garrido, Jose Lui, de Gasper, André Luí, Gea-Izquierdo, Guillermo, Gibson, David, Gillison, Andrew N, Giroldo, Aelton, Glasenhardt, Mary-Claire, Gleason, Sean, Gliesch, Mariana, Goldberg, Emma, Göldel, Bastian, Gonzalez-Akre, Erika, Gonzalez-Andujar, Jose L, González-Melo, André, González-Robles, Ana, Graae, Bente Jessen, Granda, Elena, Graves, Sarah, Green, Walton A, Gregor, Thoma, Gross, Nicola, Guerin, Greg R, Günther, Angela, Gutiérrez, Alvaro G, Haddock, Lillie, Haines, Anna, Hall, Jefferson, Hambuckers, Alain, Han, Wenxuan, Harrison, Sandy P, Hattingh, Wesley, Hawes, Joseph E, He, Tianhua, He, Pengcheng, Heberling, Jacob Mason, Helm, Aveliina, Hempel, Stefan, Hentschel, Jörn, Hérault, Bruno, Hereş, Ana-Maria, Herz, Katharina, Heuertz, Myriam, Hickler, Thoma, Hietz, Peter, Higuchi, Pedro, Hipp, Andrew L, Hirons, Andrew, Hock, Maria, Hogan, James Aaron, Holl, Karen, Honnay, Olivier, Hornstein, Daniel, Hou, Enqing, Hough-Snee, Nate, Hovstad, Knut Ander, Ichie, Tomoaki, Igić, Bori, Illa, Estela, Isaac, Marney, Ishihara, Masae, Ivanov, Leonid, Ivanova, Larissa, Iversen, Colleen M, Izquierdo, Jordi, Jackson, Robert B, Jackson, Benjamin, Jactel, Hervé, Jagodzinski, Andrzej M, Jandt, Ute, Jansen, Steven, Jenkins, Thoma, Jentsch, Anke, Jespersen, Jens Rasmus Plantener, Jiang, Guo-Feng, Johansen, Jesper Liengaard, Johnson, David, Jokela, Eric J, Joly, Carlos Alfredo, Jordan, Gregory J, Joseph, Grant Stuart, Junaedi, Decky, Junker, Robert R, Justes, Eric, Kabzems, Richard, Kane, Jeffrey, Kaplan, Zdenek, Kattenborn, Teja, Kavelenova, Lyudmila, Kearsley, Elizabeth, Kempel, Anne, Kenzo, Tanaka, Kerkhoff, Andrew, Khalil, Mohammed I, Kinlock, Nicole L, Kissling, Wilm Daniel, Kitajima, Kaoru, Kitzberger, Thoma, Kjøller, Rasmu, Klein, Tamir, Kleyer, Michael, Klimešová, Jitka, Klipel, Joice, Kloeppel, Brian, Klotz, Stefan, Knops, Johannes M H, Kohyama, Takashi, Koike, Fumito, Kollmann, Johanne, Komac, Benjamin, Komatsu, Kimberly, König, Christian, Kraft, Nathan J B, Kramer, Koen, Kreft, Holger, Kühn, Ingolf, Kumarathunge, Dushan, Kuppler, Jona, Kurokawa, Hiroko, Kurosawa, Yoko, Kuyah, Shem, Laclau, Jean-Paul, Lafleur, Benoit, Lallai, Erik, Lamb, Eric, Lamprecht, Andrea, Larkin, Daniel J, Laughlin, Daniel, Le Bagousse-Pinguet, Yoann, le Maire, Guerric, le Roux, Peter C, le Roux, Elizabeth, Lee, Tali, Lens, Frederic, Lewis, Simon L, Lhotsky, Barbara, Li, Yuanzhi, Li, Xine, Lichstein, Jeremy W, Liebergesell, Mario, Lim, Jun Ying, Lin, Yan-Shih, Linares, Juan Carlo, Liu, Chunjiang, Liu, Daijun, Liu, Udayangani, Livingstone, Stuart, Llusià, Joan, Lohbeck, Madelon, López-García, Álvaro, Lopez-Gonzalez, Gabriela, Lososová, Zdeňka, Louault, Frédérique, Lukács, Balázs A, Lukeš, Petr, Luo, Yunjian, Lussu, Michele, Ma, Siyan, Maciel Rabelo Pereira, Camilla, Mack, Michelle, Maire, Vincent, Mäkelä, Annikki, Mäkinen, Harri, Malhado, Ana Claudia Mende, Mallik, Azim, Manning, Peter, Manzoni, Stefano, Marchetti, Zuleica, Marchino, Luca, Marcilio-Silva, Viniciu, Marcon, Eric, Marignani, Michela, Markesteijn, Lar, Martin, Adam, Martínez-Garza, Cristina, Martínez-Vilalta, Jordi, Mašková, Tereza, Mason, Kelly, Mason, Norman, Massad, Tara Joy, Masse, Jacynthe, Mayrose, Itay, Mccarthy, Jame, Mccormack, M Luke, Mcculloh, Katherine, Mcfadden, Ian R, Mcgill, Brian J, Mcpartland, Mara Y, Medeiros, Juliana S, Medlyn, Belinda, Meerts, Pierre, Mehrabi, Zia, Meir, Patrick, Melo, Felipe P L, Mencuccini, Maurizio, Meredieu, Céline, Messier, Julie, Mészáros, Ilona, Metsaranta, Juha, Michaletz, Sean T, Michelaki, Chrysanthi, Migalina, Svetlana, Milla, Ruben, Miller, Jesse E D, Minden, Vanessa, Ming, Ray, Mokany, Karel, Moles, Angela T, Molnár, Attila, Molofsky, Jane, Molz, Martin, Montgomery, Rebecca A, Monty, Arnaud, Moravcová, Lenka, Moreno-Martínez, Alvaro, Moretti, Marco, Mori, Akira S, Mori, Shigeta, Morris, Dave, Morrison, Jane, Mucina, Ladislav, Mueller, Sandra, Muir, Christopher D, Müller, Sandra Cristina, Munoz, Françoi, Myers-Smith, Isla H, Myster, Randall W, Nagano, Masahiro, Naidu, Shawna, Narayanan, Ayyappan, Natesan, Balachandran, Negoita, Luka, Nelson, Andrew S, Neuschulz, Eike Lena, Ni, Jian, Niedrist, Georg, Nieto, Jhon, Niinemets, Ülo, Nolan, Rachael, Nottebrock, Henning, Nouvellon, Yann, Novakovskiy, Alexander, Nystuen, Kristin Odden, O'Grady, Anthony, O'Hara, Kevin, O'Reilly-Nugent, Andrew, Oakley, Simon, Oberhuber, Walter, Ohtsuka, Toshiyuki, Oliveira, Ricardo, Öllerer, Kinga, Olson, Mark E, Onipchenko, Vladimir, Onoda, Yusuke, Onstein, Renske E, Ordonez, Jenny C, Osada, Noriyuki, Ostonen, Ivika, Ottaviani, Gianluigi, Otto, Sarah, Overbeck, Gerhard E, Ozinga, Wim A, Pahl, Anna T, Paine, C E Timothy, Pakeman, Robin J, Papageorgiou, Aristotelis C, Parfionova, Evgeniya, Pärtel, Meeli, Patacca, Marco, Paula, Susana, Paule, Juraj, Pauli, Harald, Pausas, Juli G, Peco, Begoña, Penuelas, Josep, Perea, Antonio, Peri, Pablo Lui, Petisco-Souza, Ana Carolina, Petraglia, Alessandro, Petritan, Any Mary, Phillips, Oliver L, Pierce, Simon, Pillar, Valério D, Pisek, Jan, Pomogaybin, Alexandr, Poorter, Hendrik, Portsmuth, Angelika, Poschlod, Peter, Potvin, Catherine, Pounds, Devon, Powell, A Shafer, Power, Sally A, Prinzing, Andrea, Puglielli, Giacomo, Pyšek, Petr, Raevel, Valerie, Rammig, Anja, Ransijn, Johanne, Ray, Courtenay A, Reich, Peter B, Reichstein, Marku, Reid, Douglas E B, Réjou-Méchain, Maxime, de Dios, Victor Resco, Ribeiro, Sabina, Richardson, Sarah, Riibak, Kersti, Rillig, Matthias C, Riviera, Fiamma, Robert, Elisabeth M R, Roberts, Scott, Robroek, Bjorn, Roddy, Adam, Rodrigues, Arthur Viniciu, Rogers, Alistair, Rollinson, Emily, Rolo, Victor, Römermann, Christine, Ronzhina, Dina, Roscher, Christiane, Rosell, Julieta A, Rosenfield, Milena Fermina, Rossi, Christian, Roy, David B, Royer-Tardif, Samuel, Rüger, Nadja, Ruiz-Peinado, Ricardo, Rumpf, Sabine B, Rusch, Graciela M, Ryo, Masahiro, Sack, Lawren, Saldaña, Angela, Salgado-Negret, Beatriz, Salguero-Gomez, Roberto, Santa-Regina, Ignacio, Santacruz-García, Ana Carolina, Santos, Joaquim, Sardans, Jordi, Schamp, Brandon, Scherer-Lorenzen, Michael, Schleuning, Matthia, Schmid, Bernhard, Schmidt, Marco, Schmitt, Sylvain, Schneider, Julio V, Schowanek, Simon D, Schrader, Julian, Schrodt, Franziska, Schuldt, Bernhard, Schurr, Frank, Selaya Garvizu, Galia, Semchenko, Marina, Seymour, Colleen, Sfair, Julia C, Sharpe, Joanne M, Sheppard, Christine S, Sheremetiev, Serge, Shiodera, Satomi, Shipley, Bill, Shovon, Tanvir Ahmed, Siebenkäs, Alrun, Sierra, Carlo, Silva, Vasco, Silva, Mateu, Sitzia, Tommaso, Sjöman, Henrik, Slot, Martijn, Smith, Nicholas G, Sodhi, Darwin, Soltis, Pamela, Soltis, Dougla, Somers, Ben, Sonnier, Grégory, Sørensen, Mia Vedel, Sosinski, Enio Egon, Soudzilovskaia, Nadejda A, Souza, Alexandre F, Spasojevic, Marko, Sperandii, Marta Gaia, Stan, Amanda B, Stegen, Jame, Steinbauer, Klau, Stephan, Jörg G, Sterck, Frank, Stojanovic, Dejan B, Strydom, Tanya, Suarez, Maria Laura, Svenning, Jens-Christian, Svitková, Ivana, Svitok, Marek, Svoboda, Miroslav, Swaine, Emily, Swenson, Nathan, Tabarelli, Marcelo, Takagi, Kentaro, Tappeiner, Ulrike, Tarifa, Rubén, Tauugourdeau, Simon, Tavsanoglu, Cagatay, Te Beest, Mariska, Tedersoo, Leho, Thiffault, Nelson, Thom, Dominik, Thomas, Evert, Thompson, Ken, Thornton, Peter E, Thuiller, Wilfried, Tichý, Lubomír, Tissue, David, Tjoelker, Mark G, Tng, David Yue Phin, Tobias, Joseph, Török, Péter, Tarin, Tonantzin, Torres-Ruiz, José M, Tóthmérész, Béla, Treurnicht, Martina, Trivellone, Valeria, Trolliet, Franck, Trotsiuk, Volodymyr, Tsakalos, James L, Tsiripidis, Ioanni, Tysklind, Nikla, Umehara, Toru, Usoltsev, Vladimir, Vadeboncoeur, Matthew, Vaezi, Jamil, Valladares, Fernando, Vamosi, Jana, van Bodegom, Peter M, van Breugel, Michiel, Van Cleemput, Elisa, van de Weg, Martine, van der Merwe, Stephni, van der Plas, Fon, van der Sande, Masha T, van Kleunen, Mark, Van Meerbeek, Koenraad, Vanderwel, Mark, Vanselow, Kim André, Vårhammar, Angelica, Varone, Laura, Vasquez Valderrama, Maribel Yesenia, Vassilev, Kiril, Vellend, Mark, Veneklaas, Erik J, Verbeeck, Han, Verheyen, Kri, Vibrans, Alexander, Vieira, Ima, Villacís, Jaime, Violle, Cyrille, Vivek, Pandi, Wagner, Katrin, Waldram, Matthew, Waldron, Anthony, Walker, Anthony P, Waller, Martyn, Walther, Gabriel, Wang, Han, Wang, Feng, Wang, Weiqi, Watkins, Harry, Watkins, Jame, Weber, Ulrich, Weedon, James T, Wei, Liping, Weigelt, Patrick, Weiher, Evan, Wells, Aidan W, Wellstein, Camilla, Wenk, Elizabeth, Westoby, Mark, Westwood, Alana, White, Philip John, Whitten, Mark, Williams, Mathew, Winkler, Daniel E, Winter, Klau, Womack, Chevonne, Wright, Ian J, Wright, S Joseph, Wright, Justin, Pinho, Bruno X, Ximenes, Fabiano, Yamada, Toshihiro, Yamaji, Keiko, Yanai, Ruth, Yankov, Nikolay, Yguel, Benjamin, Zanini, Kátia Janaina, Zanne, Amy E, Zelený, David, Zhao, Yun-Peng, Zheng, Jingming, Zheng, Ji, Ziemińska, Kasia, Zirbel, Chad R, Zizka, Georg, Zo-Bi, Irié Casimir, Zotz, Gerhard, Wirth, Christian, AXA Research Fund, Commission of the European Communities, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paul-Valéry - Montpellier 3 (UPVM)-École pratique des hautes études (EPHE), Leydet, Michelle, Max Planck Institute for Biogeochemistry, German Center for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig, Universidad Nacional de Córdoba, LECA, Imperial College, Université Paris-Saclay, Tarbiat Modares University, University of Roma Tre, Tohoku University, IMBE, Universidad de Jaén, Instituto Alexander Von Humboldt, National Institute of Amazonian Research (INPA), Suez Canal University, Université de Lorraine, University of Göttingen, Universidad Nacional de Río Negro, Conicet-Consejo Nacional de Investigaciones Científicas y Técnicas, Pacific Northwest National Laboratory, University of Massachusetts Amherst, Wageningen University, University of Victoria, James Cook University, University of Pittsburgh, Université Laval, Arizona State University, University of North Florida, Australian National University, Natural Resources Canada, University of Copenhagen, Royal Botanic Gardens Kew, University of Groningen, University of California Berkeley, Wilfrid Laurier University, University of Minnesota, The University of Adelaide, UMR SELMET, Univ Montpellier, University of California at Berkeley, Colorado State University, Ghent University, Helmholtz Centre for Environmental Research – UFZ, Royal Museum for Central Africa, University of Tennessee, Rocky Mountain Biological Laboratory, Université du Québec À Montréal, Museo Nacional de Ciencias Naturales-CSIC, Universidad Nacional de Colombia, Fundación Natura, Universidade Federal do Rio Grande do Sul, Northern Arizona University, Friedrich Schiller University Jena, ETH Zurich, University of 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de Ecología (IPE-CSIC), Colgate University, University of Camerino, University of the Basque Country UPV/EHU, CATIE-Centro Agronómico Tropical de Investigación y Enseñanza, BIOGECO, King's College London, University of Insubria, Alma Mater Studiorum – University of Bologna, Universidad de Costa Rica, The University of Arizona, University of Alaska Fairbanks, Royal Botanic Gardens, WSL Swiss Federal Research Institute, University of British Columbia, CREA – Research Centre for Forestry and Wood, Jungwon University, University of Pisa, University of Lleida, Joint Research Unit CTFC – AGROTECNIO, University of California Riverside, University of Life Sciences Prague, Czech Academy of Sciences, University of Cambridge, Vrije Universiteit, UNSW Sydney, Jonah Ventures, Universidad Mayor, Swedish University of Agricultural Sciences, Nelson Mandela University, MTA Centre for Ecological Research, UMR Silva, Santa Catarina State University, Michigan State University, Institute of Biology of Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, University of Science – Vietnam National University Ho Chi Minh City, University of Pretoria, Netherlands Institute of Ecology, UFZ – Helmholtz Centre for Environmental Research, Seoul National University, Institute of Temperate Forest Sciences (ISFORT), UQO, Université de la Guyane), Goethe-Universität Frankfurt, Iluka Resources, The University of Western Australia, University of Vienna, University of South Bohemia, Karlstad University, Earth and Environmental Sciences – University of Birmingham, Spanish National Research Council – CSIC, CREAF, University of Maryland, University of A Coruña, Rutgers University, Peking University, Ordu University, Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA), Universidade Estadual Paulista (Unesp), Queensland University of Technology (QUT), Arnold Arboretum of Harvard University, Université de Rouen, University of Liège, Géopole de l'Université de Sherbrooke, Paul Sabatier University Toulouse, University of Manchester, Universidade Federal do Rio Grande do Norte – UFRN, Universidad Rey Juan Carlos, Universidad Nacional de La Patagonia Austral, Univ. Paul Valéry, Consejo Superior de Investigaciones Científicas, Universidade Regional de Blumenau, Southern Illinois University Carbondale, Instituto Federal de Educação Ciência e Tecnologia do Ceará, Agricultural Research Service, ETH Zürich (Swiss Federal Institute of Technology), CSIC – Institute for Sustainable Agriculture (IAS), Universidad del Rosario, Norwegian University of Science and Technology NTNU, University of Alcalá, UMR Ecosystème Prairial, The University of Manchester, China Agricultural University, Chinese Academy of Sciences, University of Reading, University of the Witwatersrand, Anglia Ruskin University, Norwegian University of Life Sciences, Curtin University, INP-HB, Scientific Campus of the University of the Basque Country, Goethe University, University of Natural Resources and Life Sciences, The Field Museum, Florida International University, US Department of Energy, Santa Cruz, Evolution and Biodiversity Conservation, Kochi University, University of Illinois at Chicago, Universitat de Barcelona, University of Toronto, Ural Branch of the Russian Academy of Sciences, Oak Ridge National Laboratory, Universitat Politècnica de Catalunya, Polish Academy of Sciences, Poznan University of Life Sciences, Ulm University, Guangxi University, Jl. Kebun Raya Cibodas, Philipps-University Marburg, University Salzburg, CIRAD, Humboldt State University, The Czech Academy of Sciences, Charles University, Karlsruhe Institute of Technology, Forestry and Forest Products Research Institute, State University of New York at Stony Brook, University of Amsterdam, CONICET, Universidad Nacional del Comahue, Weizmann Institute of Science, Helmholtz Centre for Environmental Research-UFZ, Xi'an Jiaotong Liverpool University, Technical University of Munich, Wageningen University & Research, Land Life Company, Coconut Research Institute of Sri Lanka, UMR Eco&Sols, University of Montpellier, Université du Québec en Abitibi-Témiscamingue, University of Saskatchewan, University of Natural Resources and Life Sciences Vienna, University of Wyoming, University of Wisconsin Eau Claire, Naturalis Biodiversity Center, University College London, Sun Yat-sen University, University of Leipzig, Shanghai Jiao Tong University, National Forestry and Grassland Administration, Universitat Autònoma de Barcelona, Wageningen University and Research, World Agroforestry (ICRAF), University of Jaén, DRI, Global Change Research Institute AS CR, Université du Québec à Trois-Rivières, Federal University of Alagoas, Bolin Centre for Climate Research, Universidad Autónoma del Estado de Morelos, Manaaki Whenua - Landcare Research, Institut de recherche en biologie végétale, Université de Montréal, Tel Aviv University, The University of Queensland, CSIRO, Manaaki Whenua – Landcare Research, Université Libre de Bruxelles, The Australian National University, The University of Edinburgh, Universidade Federal de Pernambuco (UFPE), ICREA, UEFP, University of Waterloo, Tulipan s/n, Vrije Universiteit Brussel, University of Illinois at Urbana-Champaign, University of Vermont, Centre for Northern Forest Ecosystem Research, Matieland, University of Freiburg, University of Hawai'i, Université Grenoble-Alpes, French Institute of Pondicherry, Oklahoma State University, Charles Darwin Research Station, University of Idaho, Instituto de Investigación de Recursos Biológicos Alexander von Humboldt, Universidad Distrital Francisco José de Caldas, NORD University, NTNU, Gifu University, Romanian Academy, Tercer Circuito s/n de Ciudad Universitaria, Universidad Nacional Autónoma de México, Moscow Lomonosov State University, Universidad de las Américas, Wageningen Environmental Research, Technische Universität München, University of New England, Democritus University of Thrace, Universidad Austral de Chile, Desertification Research Center (CIDE-CSIC), Universidad Autónoma de Madrid, Instituto Nacional de Tecnología Agropecuaria (INTA), National Institute for Research-Development in Forestry, University of Regensburg, McGill University, Morton Arboretum, Université Rennes 1/CNRS, Université Paul Valéry, Southwest University of Science and Technology, Universitat de Lleida, Universidade Federal do Acre, Manaaki Whenua-Landcare Research, Centre for Ecological Research and Forestry Applications (CREAF), Royal Museum for Central-Africa (RMCA), Mississippi State University, Radboud University Nijmegen, Yale University, Brookhaven National Laboratory, Ciudad Universitaria, University of Zurich, Chastè Planta-Wildenberg, Centre for Ecology & Hydrology (CEH), Canadian Forest Service, University of Valladolid-INIA, University of Lausanne, Norwegian Institute for Nature Research, Oxford University, Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC), Universidade de Coimbra, Senckenberg Biodiversität und Klima Forschungszentrum (SBiK-F), Palmengarten der Stadt Frankfurt am Main, Research Institute for Humanity and Nature, University of Regina, Technische Universität Ilmenau, Università degli Studi di Padova, Gothenburg Botanical Garden, Texas Tech University, Archbold Biological Station, Universidade Federal do Rio Grande do Norte, Slovak Academy of Sciences, Czech University of Life Sciences, Estación Experimental de Zonas Áridas (CSIC), CIRAD-UMR SELMET-PZZS, Hacettepe University, Utrecht University, Canadian Wood Fibre Centre, University of Sheffield, Silwood Park, MTA-DE Lendület Functional and Restoration Ecology Research Group, University of Delaware, UMR PIAF, MTA-TKI Biodiversity and Ecosystem Services Research Group, University of Illinois, Botanical Garden of Ural Branch of Russian Academy of Sciences, University of New Hampshire, National University of Singapore, Edinburgh University, Florida Institute of Technology, University of Konstanz, Taizhou University, University of Erlangen-Nuremberg, Universidad de Concepcion, Bulgarian Academy of Sciences, Museu Paraense Emilio Goeldi, Universidad de las Fuerzas Armadas (ESPE), Goa University, Pondicherry University, Carl von Ossietzky University of Oldenburg, Cambridge Conservation Initiative, Tsinghua University, Chinese Academy of Forestry, Fujian Normal University, Vrije Universiteit Amsterdam, Maritime and Science Technology Academy, University of Winnipeg, King Saud University, University of California – Irvine, U. S. Geological Survey, Duke University, NSW Department of Primary Industries, SUNY-College of Environmental Science and Forestry, Sorbonne-Université, Laboratório de Ecologia Vegetal (LEVEG), George Washington University, National Taiwan University, Institut National Polytechnique Félix Houphouët-Boigny (INP-HB), University Oldenburg, and Biyoloji
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[SDE] Environmental Sciences ,LIFE-HISTORY ,Geography & travel ,WOOD DENSITY ,plant trait ,Biodiversity & Conservation ,05 Environmental Sciences ,Growth ,580 Plants (Botany) ,COMMUNITY COMPOSITION ,ROOT TRAITS ,Biologiska vetenskaper ,Ecological modeling ,data coverage ,data integration ,data representativeness ,functional diversity ,plant traits ,TRY plant trait database ,Biodiversity ,Ecology ,Plants ,Access to Information ,Ecosystem ,data representativene ,ddc:910 ,General Environmental Science ,Global and Planetary Change ,GLOBAL PATTERNS ,food and beverages ,LEAF PHOTOSYNTHETIC TRAITS ,Biological Sciences ,CAVElab ,Data processing ,ddc:580 ,[SDE]Environmental Sciences ,Biodiversity Conservation ,Life Sciences & Biomedicine ,INCLINATION ANGLE DISTRIBUTION ,Environmental Sciences & Ecology ,Ecology and Environment ,Database ,LITTER DECOMPOSITION ,ddc:570 ,Datenintegration ,Environmental Chemistry ,DDC 004 / Data processing & computer science ,Intraspecific competition ,Data integration (Computer science) ,Science & Technology ,Biology and Life Sciences ,Plant ,06 Biological Sciences ,Environmental factor ,Nutrient Network ,Biology and Microbiology ,FUNCTIONAL TRAITS ,DDC 580 / Botanical sciences ,Earth and Environmental Sciences ,ddc:004 ,[SDE.BE]Environmental Sciences/Biodiversity and Ecology ,Environmental Sciences ,RELATIVE GROWTH-RATE - Abstract
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait-based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits—almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives., publishedVersion
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- 2020
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6. Comparative Study on Frequency of Various Papillary Pattern Types in Estonian Men and Women
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Aelita Zīle, Silvia Kaugia, Annika Lall, University of Tartu, Estonia, Retired Police Lieutenant Colonel, Estonia, and Rīga Stradiņš University, Faculty of Law, Latvia
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comparative analysis ,business.industry ,men ,Estonian ,language.human_language ,loop ridge pattern ,right hand ,left hand ,language ,Socrates 2021, 2 (20) ,Medicine ,whorl ridge pattern ,Papillary pattern ,women ,arch ridge pattern ,business ,Demography - Abstract
The authors of the article conducted a comparative study to determine the incidence frequency of various papillary patterns in men and women. In the framework of this study, the authors collected and performed analysis on data published in the subject literature. Comparative analysis was performed to check for potential similarities and differences in papillary patterns, types, and groups in men and women, using data on the patterns in both hands. This article presents the results of the study. This research is funded by the Latvian-Ukrainian Joint Programme of Scientific and Technological Cooperation Project (2021) "Open Educational Resource: Forensic Science”, Project No. LV-UA/2021/3.
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- 2021
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7. European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure
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Simona Sacco, Christian Lampl, Faisal Mohammad Amin, Mark Braschinsky, Christina Deligianni, Derya Uludüz, Jan Versijpt, Anne Ducros, Raquel Gil-Gouveia, Zaza Katsarava, Paolo Martelletti, Raffaele Ornello, Bianca Raffaelli, Deirdre M. Boucherie, Patricia Pozo-Rosich, Margarita Sanchez-del-Rio, Alexandra Sinclair, Antoinette Maassen van den Brink, Uwe Reuter, Veritati - Repositório Institucional da Universidade Católica Portuguesa, Institut Català de la Salut, [Sacco S] Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Via Vetoio 1, L’Aquila, Italy. [Lampl C] Department of Neurology, Headache Medical Center at the Konventhospital BHB Linz, Linz, Austria. [Amin FM] Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, University of Copenhagen, Copenhagen, Denmark. Department of Neurorehabilitation/Traumatic Brain Injury, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. [Braschinsky M] Department of Neurology, Institute of Clinical Medicine, University of Tartu, Headache Clinic, Department of Neurology, Tartu University Hospital, Tartu, Estonia. [Deligianni C] Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, University of Copenhagen, Copenhagen, Denmark. [Uludüz D] Department of Neurology Istanbul Cerrahpasa Medical Faculty, Istanbul, Turkey. [Pozo-Rosich P] Unitat de Cefalea, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca en Cefalea i Dolor Neurològic, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Brussels Heritage Lab, Clinical sciences, Neuroprotection & Neuromodulation, and Neurology
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Consensus ,enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos con cefaleas::cefaleas primarias::trastornos migrañosos [ENFERMEDADES] ,NSAIDs ,Neuroscience(all) ,Migraine Disorders ,Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Neurotransmitter [CHEMICALS AND DRUGS] ,aminoácidos, péptidos y proteínas::proteínas::proteínas de membranas::receptores de superficie celular::receptores de neurotransmisores [COMPUESTOS QUÍMICOS Y DROGAS] ,Medizin ,Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] ,Migranya - Tractament ,Other subheadings::Other subheadings::/drug therapy [Other subheadings] ,Neurotransmissors - Receptors ,Humans ,Tryptamines/pharmacology ,Serotonin 5-HT1 Receptor Agonists/therapeutic use ,Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders [DISEASES] ,Migraine ,Headache/drug therapy ,Headache ,Presa de decisions ,General Medicine ,Attack ,Serotonin 5-HT1 Receptor Agonists ,Psychological Phenomena::Mental Processes::Thinking::Decision Making::Consensus [PSYCHIATRY AND PSYCHOLOGY] ,Tryptamines ,Ditan ,Migraine Disorders/diagnosis ,Triptan ,Anesthesiology and Pain Medicine ,Neurology (clinical) ,fenómenos psicológicos::procesos mentales::pensamiento::toma de decisión::consenso [PSIQUIATRÍA Y PSICOLOGÍA] ,Transcription Factors/therapeutic use ,Gepant ,Transcription Factors - Abstract
BackgroundTriptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder.Main bodyThe Consensus process included a preliminary literature review, a Delphi round and a subsequent open discussion. According to the Consensus Panel, effective treatment of a migraine attack is to be defined on patient well-being featured by a) improvement of headache, b) relief of non-pain symptoms and c) absence of adverse events. An attack is considered effectively treated if patient’s well-being, as defined above, is restored within 2 hours and for at least 24 hours. An individual with migraine is considered as triptan-responder when the given triptan leads to effective acute attack treatment in at least three out of four migraine attacks. On the other hand, an individual with migraine is considered triptan non-responder in the presence of failure of a single triptan (not matching the definition of triptan-responder). The Consensus Panel defined an individual with migraine as triptan-resistant in the presence of failure of at least 2 triptans; triptan refractory, in the presence of failure to at least 3 triptans, including subcutaneous formulation; triptan ineligibile in the presence of an acknowledged contraindication to triptan use, as specified in the summary of product characteristics.ConclusionsThe novel definitions can be useful in clinical practice for the assessment of acute attack treatments patients with migraine. They may be helpful in identifying people not responding to triptans and in need for novel acute migraine treatments. The definitions will also be of help in standardizing research on migraine acute care. Background: Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. Main body: The Consensus process included a preliminary literature review, a Delphi round and a subsequent open discussion. According to the Consensus Panel, effective treatment of a migraine attack is to be defined on patient well-being featured by a) improvement of headache, b) relief of non-pain symptoms and c) absence of adverse events. An attack is considered effectively treated if patient’s well-being, as defined above, is restored within 2 hours and for at least 24 hours. An individual with migraine is considered as triptan-responder when the given triptan leads to effective acute attack treatment in at least three out of four migraine attacks. On the other hand, an individual with migraine is considered triptan non-responder in the presence of failure of a single triptan (not matching the definition of triptan-responder). The Consensus Panel defined an individual with migraine as triptan-resistant in the presence of failure of at least 2 triptans; triptan refractory, in the presence of failure to at least 3 triptans, including subcutaneous formulation; triptan ineligibile in the presence of an acknowledged contraindication to triptan use, as specified in the summary of product characteristics. Conclusions: The novel definitions can be useful in clinical practice for the assessment of acute attack treatments patients with migraine. They may be helpful in identifying people not responding to triptans and in need for novel acute migraine treatments. The definitions will also be of help in standardizing research on migraine acute care.
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- 2022
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8. Priorities for collaborative research using very preterm birth cohorts
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Jo Lebeer, Jennifer Zeitlin, Heili Varendi, Elizabeth S Draper, Andrei S. Morgan, Henrique Barros, Rolf F. Maier, Mikael Norman, Pierre-Yves Ancel, Marina Cuttini, Mariane Sentenac, Samantha Johnson, Instituto de Saúde Pública da Universidade do Porto, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Epidemiology Research Unit [Porto, Portugal] (EPIUnit), Instituto de Saúde Pública [Porto, Portugal], Universidade do Porto-Universidade do Porto, Clinical Care and Management Innovation Research Area [Roma, Lazio, Italy], Children's Hospital Bambino Gesù IRCCS [Rome], Department of Health Sciences [Leicester], University of Leicester, Department of Primary & Interdisciplinary Care, Disability Studies [Antwerpen, Belgium] (Faculty of Medicine), University of Antwerp (UA), Philipps University of Marburg, Department of Clinical Science, Intervention and Technology [Stockholm, Sweden], Karolinska Institutet [Stockholm], Department of Neonatal Medicine [Stockholm, Sweden], Karolinska University Hospital [Stockholm], University of Tartu, Tartu University Hospital [Tartu, Estonia], This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 733280., RECAP Preterm child cohort research group : Ådén U, Benhammou V, Bilsteen JF, Boerch K, Halvorsen T, Kajantie E, Kallen K, Lehtonen L, Pierrat V, Sarrechia I, Reempts PV, Walz JM, Wolke D, Ylijoki M., European Project: 733280,RECAP preterm, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade do Porto = University of Porto-Universidade do Porto = University of Porto, Philipps Universität Marburg = Philipps University of Marburg, Sentenac, Mariane, RECAP preterm: Research on European Children and Adults born Preterm - RECAP preterm - 0000-00-00 - 0000-00-00 - 733280 - VALID, Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade do Porto [Porto]-Universidade do Porto [Porto], and European Project: 0733280(2007)
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Male ,Parents ,medicine.medical_specialty ,Delphi Technique ,Emotions ,education ,Nutritional Status ,neonatology ,03 medical and health sciences ,Child Development ,0302 clinical medicine ,030225 pediatrics ,Epidemiology ,medicine ,Humans ,Very Preterm Birth ,030212 general & internal medicine ,Neonatology ,Cooperative Behavior ,Original Research ,neurodevelopment ,Socioemotional selectivity theory ,business.industry ,Research ,Extremely preterm ,Infant, Newborn ,Stakeholder ,Obstetrics and Gynecology ,General Medicine ,patient perspective ,3. Good health ,Very preterm ,Mental Health ,Socioeconomic Factors ,Ranking ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Infant, Extremely Premature ,Family medicine ,Pediatrics, Perinatology and Child Health ,Female ,epidemiology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Human medicine ,business ,Stress, Psychological - Abstract
ObjectivesTo develop research priorities on the consequences of very preterm (VPT) birth for the RECAP Preterm platform which brings together data from 23 European VPT birth cohorts.Design and settingThis study used a two-round modified Delphi consensus process. Round 1 was based on 28 research themes related to childhood outcomes (ResultsOf 71 individuals contacted, 64 (90%) participated as panel members comprising obstetricians, neonatologists, nurses, general and specialist paediatricians, psychologists, physiotherapists, parents, adults born preterm, policy makers and epidemiologists from 17 countries. All 28 initial themes were ranked in the top 10 by at least six panel members. Highest ranking themes were: education (73% of panel members' top 10 choices); care and outcomes of extremely preterm births, including ethical decisions (63%); growth and nutrition (60%); emotional well-being and social inclusion (55%); parental stress (55%) and impact of social circumstances on outcomes (52%). Highest ranking themes were robust across panel members classified by background. 15 new themes had at least 6 top 10 endorsements in round 2.ConclusionsThis study elicited a broad range of research priorities on the consequences of VPT birth, with good consensus on highest ranks between stakeholder groups. Several highly ranked themes focused on the socioemotional needs of children and parents, which have been less studied.
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- 2020
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9. Discovery of genes that modulate flavivirus replication in an interferon-dependent manner
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Lesage, Sarah, Chazal, Maxime, Beauclair, Guillaume, Batalie, Damien, Cerboni, Silvia, Couderc, Elodie, Lescure, Aurianne, Del Nery, Elaine, Tangy, Frédéric, Martin, Annette, Manel, Nicolas, Jouvenet, Nolwenn, Signalisation antivirale - Virus sensing and signaling, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Immunité et cancer (U932), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), BioImaging Cell and Tissue Core Facility (PICT-IBiSA), Institut Curie [Paris], Génomique virale et vaccination, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was funded by the CNRS, INSERM, Institut Pasteur, Institut Curie, ‘Urgence COVID-19’ fundraising campaign of Institut Pasteur, LABEX VRI (ANR-10-LABX-77), LABEX DCBIOL (ANR-10-IDEX-0001-02 PSL* and ANR-11LABX-0043), the Région Ile-de-France (DIM1HEALTH 2019), EMBO Young Investigator programm bringing fund and the Agence Nationale de la Recherche sur le sida et les hépatites virales (ANRS-CSS12-2019-2). The BioPhenics laboratory is supported by Institut Curie, IBiSA (PICT-IBiSA) and part of ChemBioFRance and France-BioImaging infrastructure supported by the French National Research Agency (ANR-10-INSB-04, «Investments for the future»). SL was the recipient of a Université de Paris PhD fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., We thank Dr. M.A. Saleem (University of Bristol, UK) for generously providing the podocytes (via E. Pays, Université Libre de Bruxelles, Belgium), C.M. Rice (Rockefeller University, New York, USA) for Huh-7.5 cells, Cinzia Traboni (IRBM, Pomezia, Italy) for Huh-7 cells, M. Bessaud (Institut Pasteur) for the CVB3 Nancy strain, N. Escriou (Institut Pasteur) for the VSV Indiana strain and anti-VSV-G antibodies, V. M. Cao-Lormeau and D. Musso (Institut Louis Malardé, Tahiti Island, French Polynesia) for the ZIKV-PF13 strain, L. Hermida and G. Enrique Guillen Nieto from the Centro de Ingeniería Genética y Biotecnología (CIGB), Cuba, for the DENV-2 strain Malaysia SB8553, T. Wakita (NIID, Tokyo, Japan) for pJFH1 HCV cDNA, R. Bartenschlager (University of Heidelberg, Germany) for pJFH1-2EI3-adapt cDNA, the French National Reference Centre for Respiratory Viruses hosted by Institut Pasteur (France) and headed by S. van der Werf for providing the historical SARS-CoV-2 viral strains, A. Merits (University of Tartu, Estonia) for anti-ZIKV NS5 antibodies, P. Desprès (Université de la Réunion, PIMIT) for 4G2 hybridoma cells, H. Mouquet (Institut Pasteur) for anti-SARS-CoV-2 S antibodies, M. Evans (Icahn School of Medicine at Mount Sinai, New York, USA) for the plasmid encoding the full-length Zika MR766 genome, F. Porrot and O. Schwartz (Institut Pasteur) for sharing MVA-GFP, C. Combredet (Institut Pasteur) for producing MeV-GFP, P. Benaroch (Institut Curie, France) for advice concerning the siRNA screening work, as well as E. Pays and S. Uzureau (Université Libre de Bruxelles, Belgium) for APOL1 and APOL3 plasmids and for stimulating APOL-focused discussions. We are grateful to the members of our laboratories for helpful discussions and technical advice. Finally, we thank Emeline Perthame (Bioinformatics and Biostatistics HUB, Institut Pasteur) for her help in statistical analysis., ANR-11-LABX-0043,DCBIOL,Biologie des cellules dendritiques(2011), ANR-10-LABX-0077,VRI,Initiative for the creation of a Vaccine Research Institute(2010), jouvenet, nolwenn, Biologie des cellules dendritiques - - DCBIOL2011 - ANR-11-LABX-0043 - LABX - VALID, Laboratoires d'excellence - Initiative for the creation of a Vaccine Research Institute - - VRI2010 - ANR-10-LABX-0077 - LABX - VALID, Institut Pasteur [Paris], CNRS UMR3569, and Centre National de la Recherche Scientifique (CNRS)
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SARS-CoV-2 ,Flavivirus ,viruses ,[SDV]Life Sciences [q-bio] ,Membrane Proteins ,RNA-Binding Proteins ,interferon-stimulated genes ,Virus Replication ,Histone Deacetylases ,Zika virus ,Repressor Proteins ,antiviral response ,[SDV] Life Sciences [q-bio] ,Apolipoproteins L ,MTA2 ,Humans ,APOL3 ,Interferons ,ComputingMilieux_MISCELLANEOUS ,ComputingMethodologies_COMPUTERGRAPHICS ,Research Article - Abstract
Graphical abstract, Establishment of the interferon (IFN)-mediated antiviral state provides a crucial initial line of defense against viral infection. Numerous genes that contribute to this antiviral state remain to be identified. Using a loss-of-function strategy, we screened an original library of 1156 siRNAs targeting 386 individual curated human genes in stimulated microglial cells infected with Zika virus (ZIKV), an emerging RNA virus that belongs to the flavivirus genus. The screen recovered twenty-one potential host proteins that modulate ZIKV replication in an IFN-dependent manner, including the previously known IFITM3 and LY6E. Further characterization contributed to delineate the spectrum of action of these genes towards other pathogenic RNA viruses, including Hepatitis C virus and SARS-CoV-2. Our data revealed that APOL3 acts as a proviral factor for ZIKV and several other related and unrelated RNA viruses. In addition, we showed that MTA2, a chromatin remodeling factor, possesses potent flavivirus-specific antiviral functions induced by IFN. Our work identified previously unrecognized genes that modulate the replication of RNA viruses in an IFN-dependent manner, opening new perspectives to target weakness points in the life cycle of these viruses.
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- 2021
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10. ESO guideline for the management of extracranial and intracranial artery dissection
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Stéphanie Debette, Alessandro Pezzini, Stefan T. Engelter, Mikael Mazighi, Isabella Canavero, Julien Haemmerli, Anna Bersano, Philippe Bijlenga, Avtar Lal, Marcel Arnold, David J. Seiffge, Kaori Miwa, Masatoshi Koga, Hugh S. Markus, Sabrina Schilling, Piotr Tekiela, Janika Kõrv, Jennifer J. Majersik, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), FHU NeuroVasc [Site Sainte-Anne, Paris] (GHU-PPN), Centre Hospitalier Sainte Anne [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université de Paris (UP), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Faculté de médecine [Genève], University of Brescia, National Cerebral and Cardiovascular Center (NCCC - OSAKA), Osaka University [Osaka], Fondazione IRCCS Istituto Neurologico 'Carlo Besta', University of Tartu, Tartu University Hospital [Tartu, Estonia], University of Utah, University of Bern, University of Cambridge [UK] (CAM), and University of Basel (Unibas)
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medicine.medical_specialty ,Subarachnoid hemorrhage ,medicine.medical_treatment ,Population ,030204 cardiovascular system & hematology ,Guidelines ,Extracranial artery dissection ,Cervical artery dissection ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Endovascular treatment ,cardiovascular diseases ,Intensive care medicine ,education ,Stroke ,education.field_of_study ,Aspirin ,business.industry ,Anticoagulants ,Thrombolysis ,Guideline ,medicine.disease ,3. Good health ,Clinical trial ,Intracranial artery dissection ,Observational study ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Mechanical thrombectomy ,030217 neurology & neurosurgery - Abstract
International audience; The aim of the present European Stroke Organisation guideline is to provide clinically useful evidence-based recommendations on the management of extracranial artery dissection (EAD) and intracranial artery dissection (IAD). EAD and IAD represent leading causes of stroke in the young, but are uncommon in the general population, thus making it challenging to conduct clinical trials and large observational studies. The guidelines were prepared following the Standard Operational Procedure for European Stroke Organisation guidelines and according to GRADE methodology. Our four recommendations result from a thorough analysis of the literature comprising two randomized clinical trials (RCTs) comparing anticoagulants to anti-platelets in the acute phase of ischemic stroke and twenty-six comparative observational studies. In EAD patients with acute ischemic stroke we recommend using intravenous thrombolysis (IVT) with alteplase within 4.5 hours of onset if standard inclusion/exclusion criteria are met, and mechanical thrombectomy in patients with large vessel occlusion of the anterior circulation. We further recommend early endovascular or surgical intervention for IAD patients with subarachnoid hemorrhage (SAH). Based on evidence from two phase 2 RCTs that have shown no difference between the benefits and risks of anticoagulants versus anti-platelets in the acute phase of symptomatic EAD, we strongly recommend that clinicians can prescribe either option. In post-acute EAD patients with residual stenosis or dissecting aneurysms and in symptomatic IAD patients with an intracranial dissecting aneurysm and isolated headache, there is insufficient data to provide a recommendation on the benefits and risks of endovascular/surgical treatment. Finally, nine expert consensus statements, adopted by 8 to 11 of the 11 experts involved, propose guidance for clinicians when the quality of evidence was too low to provide recommendations. Some of these pertain to the management of IAD (use of IVT, endovascular treatment, and antiplatelets versus anticoagulation in IAD with ischemic stroke and use of endovascular or surgical interventions for IAD with headache only). Other expert consensus statements address the use of direct anticoagulants and dual antiplatelet therapy in EAD-related cerebral ischemia, endovascular treatment of the EAD/IAD lesion and multidisciplinary assessment of the best therapeutic approaches in specific situations.
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- 2021
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11. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy
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Bousquet, Jean, Pfaar, Oliver, Agache, Ioana, Bedbrook, Anna, Akdis, Cezmi A, Canonica, Giorgio Walter, Chivato, Tomas, Al-Ahmad, Mona, Rasib, A. H. Abdul, Ansotegui, Ignacio J, Bachert, Claus, Soto-Martinez, Manuel, Laune, Daniel, Casale, Tomas, Levin, Michael, Larenas-Linnemann, Désirée, Samolinski, Boleslaw, Lodrup Carlsen, Karin C, O'Mahony, Liam, Lombardi, Carlo, Riggioni, Carmen, Hossny, Elham, Barata, Luís Taborda, Lourenço, Olga, Devillier, Philippe, Mahboub, Bassam, Malling, Hans-Jørgen, Sheikh, Aziz, Manning, Patrick, Passalacqua, Giovanni, Marshall, Gailen D, Sanchez-Borges, Mario, Toppila-Salmi, Sanna, Melén, Erik, Fokkens, Wytske J, Meltzer, Eli O, Miculinic, Neven, Soto-Quiros, Manuel, Milenkovic, Branislava, Roberts, Graham, Ohta, Ken, Scichilone, Nicola, Moin, Mostafa, Odemyr, Mikaëla, Montefort, Stephen, Almeida, Mário Morais, Bom, Ana Todo, Mortz, Charlotte G, Serpa, Faradiba S, Patella, Vincenzo, Sova, Milan, Mösges, Ralph, Mullol, Joaquim, Namazova Baranova, Leyla, Tsiligianni, Ioanna, Neffen, Hugo, Bjermer, Leif, Rodriguez-Gonzales, Monica, Torres, Maria J, Okamoto, Yoshitaka, Okubo, Kimi, Pajno, Giovanni B, Baharuddin, Abdullah, Cecchi, Lorenzo, Sastre, Joaquin, Untersmayr, Eva, Pawankar, Ruby, Pham-Thi, Nhân, Plavec, Davor, Cardona, Victoria, Dokic, Dejan, Sisul, Juan Carlos, Rosario, Nelson, Rottem, Menachem, Rouadi, Philip W, Del Giacco, Stefano, Fonseca, Joao A, Schwarze, Jürgen, Scadding, Glenis K, Shamji, Mohamed H, Schmid-Grendelmeier, Peter, Niedoszytko, Marek, Valentin-Rostan, Marylin, Sofiev, Mikhail, Solé, Dirceu, Sooronbaev, Talant, Palkonen, Susanna, Urrutia-Pereira, Marilyn, Skypala, Isabel, Suppli-Ulrik, Charlotte, Bonini, Matteo, Popov, Todor A, Tomazic, Peter-Valentin, Valero, Antonio, Cepeda Sarabia, Alfonso M, Ryan, Dermot, Bosnic-Anticevich, Sinthia, Valiulis, Arunas, Durham, Stephen L, Schünemann, Holger, Kalayci, Omer, Valovirta, Erkka, Panzner, Petr, Vandenplas, Olivier, Ventura, Maria Teresa, Gotua, Maia, Vichyanond, Pakit, Chkhartishvili, Ekaterine, Wagenmann, Martin, Fontaine, Jean-François, Kull, Inger, Wallace, Dana, Recto, Marysia, Walusiak-Skorupa, Jolanta, Wang, De Yun, Hrubiško, Martin, Waserman, Susan, Ebisawa, Motohiro, Bosse, Isabelle, Grisle, Ineta, Wong, Gary Wk, Bindslev-Jensen, Carsten, Yorgancioglu, Arzu, Yusuf, Osman M, Khaitov, Musa, Zernotti, Mario, Gawlik, Radoslaw, Chu, Derek K, Irani, Carla, Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, Kuna, Piotr, Jutel, Marek, Guzmán, Maria Antonieta, El-Gamal, Yehia, Klimek, Ludger, Brough, Helen A, Brussino, Luisa, Calderon, Moises A, Caraballo, Luis, O'Hehir, Robyn E, Gelincik, Asli, Kvedariene, Violeta, Cirule, Ieva, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Nekam, Kristof, Papadopoulos, Nikolaos G., Haahtela, Tari, Emuzyte, Regina, Gamkrelidze, Amiran, Fauquert, Jean Luc, Palomares, Oscar, Regateiro, Frederico S, Ivancevich, Juan Carlos, Gemicioglu, Bilun, Gereda, Jose E, Gerth van Wijk, Roy, Bergmann, Karl-Christian, Knol, Edward, Halken, Susanne, Heffler, Enrico, Hoffmann-Sommergruber, Karin, Martins, Pedro Carreiro, Kritikos, Vicky, Ispayeva, Zhanat, Julge, Kaja, Kaidashev, Igor, Demoly, Pascal, Kowalski, Marek, Kraxner, Helga, Ollert, Markus, Fiocchi, Alessandro, Lauerma, Antti, Lau, Susanne, Park, Hae-Sim, Gomez, R Maximiliano, Comprehensive Health Research Centre (CHRC) - pólo NMS, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), uBibliorum, Bousquet J., Pfaar O., Agache I., Bedbrook A., Akdis C.A., Canonica G.W., Chivato T., Al-Ahmad M., Abdul Latiff A.H., Ansotegui I.J., Bachert C., Baharuddin A., Bergmann K.-C., Bindslev-Jensen C., Bjermer L., Bonini M., Bosnic-Anticevich S., Bosse I., Brough H.A., Brussino L., Calderon M.A., Caraballo L., Cardona V., Carreiro-Martins P., Casale T., Cecchi L., Cepeda Sarabia A.M., Chkhartishvili E., Chu D.K., Cirule I., Cruz A.A., Czarlewski W., del Giacco S., Demoly P., Devillier P., Dokic D., Durham S.L., Ebisawa M., El-Gamal✝ Y., Emuzyte R., Gamkrelidze A., Fauquert J.L., Fiocchi A., Fokkens W.J., Fonseca J.A., Fontaine J.-F., Gawlik R., Gelincik A., Gemicioglu B., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gotua M., Grisle I., Guzman M.-A., Haahtela T., Halken S., Heffler E., Hoffmann-Sommergruber K., Hossny E., Hrubisko M., Irani C., Ivancevich J.C., Ispayeva Z., Julge K., Kaidashev I., Kalayci O., Khaitov M., Klimek L., Knol E., Kowalski M.L., Kraxner H., Kull I., Kuna P., Kvedariene V., Kritikos V., Lauerma A., Lau S., Laune D., Levin M., Larenas-Linnemann D.E., Lodrup Carlsen K.C., Lombardi C., Lourenco O.M., Mahboub B., Malling H.-J., Manning P., Marshall G.D., Melen E., Meltzer E.O., Miculinic N., Milenkovic B., Moin M., Montefort S., Morais-Almeida M., Mortz C.G., Mosges R., Mullol J., Namazova Baranova L., Neffen H., Nekam K., Niedoszytko M., Odemyr M., O'Hehir R.E., Ollert M., O'Mahony L., Ohta K., Okamoto Y., Okubo K., Pajno G.B., Palomares O., Palkonen S., Panzner P., G Papadopoulos N., Park H.-S., Passalacqua G., Patella V., Pawankar R., Pham-Thi N., Plavec D., Popov T.A., Recto M., Regateiro F.S., Riggioni C., Roberts G., Rodriguez-Gonzales M., Rosario N., Rottem M., Rouadi P.W., Ryan D., Samolinski B., Sanchez-Borges✝ M., Serpa F.S., Sastre J., Scadding G.K., Shamji M.H., Schmid-Grendelmeier P., Schunemann H.J., Sheikh A., Scichilone N., Sisul J.C., Sofiev M., Sole D., Sooronbaev T., Soto-Martinez M., Soto-Quiros M., Sova M., Schwarze J., Skypala I., Suppli-Ulrik C., Taborda-Barata L., Todo-Bom A., Torres M.J., Valentin-Rostan M., Tomazic P.-V., Valero A., Toppila-Salmi S., Tsiligianni I., Untersmayr E., Urrutia-Pereira M., Valiulis A., Valovirta E., Vandenplas O., Ventura M.T., Vichyanond P., Wagenmann M., Wallace D., Walusiak-Skorupa J., Wang D.Y., Waserman S., Wong G.W.K., Yorgancioglu A., Yusuf O.M., Zernotti M., Zhang L., Zidarn M., Zuberbier T., Jutel M., HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, Department of Pathology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Philipps Universität Marburg = Philipps University of Marburg, Transilvania University of Brasov, Universität Zürich [Zürich] = University of Zurich (UZH), Humanitas University [Milan] (Hunimed), Universidad San Pablo CEU, Kuwait University, Al-Rashed Allergy Center [Kuwait City], Pantai Hospital [Kuala Lumpur], Hospital Quirónsalud Bizkaia [Bilbao], Ghent University Hospital, Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Sun Yat-Sen University [Guangzhou] (SYSU), Universiti Sains Malaysia (USM), Humboldt University Of Berlin, Berlin Institute of Health (BIH), Odense University Hospital (OUH), Skane University Hospital [Lund], Fondazione Policlinico Universitario Agostino Gemelli IRCCS, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Woolcock Institute of Medical Research [Sydney], The University of Sydney, Guy's and St Thomas' Hospital [London], King‘s College London, Università degli studi di Torino = University of Turin (UNITO), University of Cartagena, Vall d'Hebron University Hospital [Barcelona], Centro Hospitalar de Lisboa Central E.P.E, NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), University of South Florida [Tampa] (USF), Azienda Usl Toscana centro [Firenze], Universidad Simon Bolivar (USB), David Tvildiani Medical University (DTMU), McMaster University [Hamilton, Ontario], Children's Clinical University Hospital [Riga, Latvia] (CCUH), Universidade Federal da Bahia (UFBA), Università degli Studi di Cagliari = University of Cagliari (UniCa), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Foch [Suresnes], Sagamihara National Hospital [Kanagawa, Japan], Université Ain Shams, Vilnius University [Vilnius], CHU Clermont-Ferrand, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Universidade do Porto = University of Porto, Silesian Medical University, Katowice, Poland, Cerrahpasa Faculty of Medicine, Istanbul University, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Universidad de Chile = University of Chile [Santiago] (UCHILE), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], Medizinische Universität Wien = Medical University of Vienna, Hôtel-Dieu de France (HDF), Université Saint-Joseph de Beyrouth (USJ), Tartu University Hospital [Tartu, Estonia], Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Hacettepe University = Hacettepe Üniversitesi, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Siriraj Hospital, Mahidol University, Mahidol University [Bangkok], Nova Southeastern University (NSU), Nofer Institute of Occupational Medicine (NIOM), National University of Singapore (NUS), Yong Loo Lin School of Medicine [Singapore], The Chinese University of Hong Kong [Hong Kong], Manisa Celal Bayar University, Universidad Nacional de Villa María, Universidad Católica de Córdoba, Beijing Tongren Hospital, Herrada, Anthony, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (MGD) Service de pneumologie
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Pulmonary and Respiratory Medicine ,precision medicine ,education ,Immunology ,Review ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,immune system diseases ,HDE ALER ,allergic rhinitis ,asthma ,immunotherapy ,Medicine and Health Sciences ,Immunology and Allergy ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,ComputingMilieux_MISCELLANEOUS ,Rhinitis ,RC581-607 ,respiratory tract diseases ,3121 General medicine, internal medicine and other clinical medicine ,Immunologic diseases. Allergy ,600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit ,[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology ,allergic rhinitis, asthma, immunotherapy, precision medicine - Abstract
Funding Information: BSreports personal fees from Allergopharma, during the conduct of the study; grants from National Health Programm, grant, personal fees from Polpharma, ASTRA, personal fees from Mylan, Adamed, patient ombudsman, national Centre for Research and Development, Polish Allergology Society. Funding Information: NGP reports personal fees from Novartis, Nutricia, HAL, MENARINI/FAES FARMA, SANOFI, MYLAN/MEDA, BIOMAY, AstraZeneca, GSK, MSD, ASIT BIOTECH, Boehringer Ingelheim, grants from Gerolymatos International SA, Capricare. Funding Information: CA reports grants from Allergopharma, grants from Idorsia, Swiss National Science Foundation, Christine Kühne‐Center for Allergy Research and Education, European Commission's Horison's 2020 Framework Programme, Cure, Novartis Research Institutes, Astra Zeneca, scibase, advisory role in Sanofi/Regeneron, grants from Glakso Smith‐Kline, advisory role in scibase. Funding Information: MJTreports grants from European Commission, SEAIC, ISCIII, personal fees from Diater laboratory, Leti laboratory, Aimmune Therapeutics. Funding Information: LK reports grants and personal fees from Allergopharma, MEDA/Mylan, LETI Pharma, Sanofi, grants from Stallergenes, Quintiles, ASIT biotech, grants from ALK Abelló, Lofarma, AstraZeneca, GSK, Inmunotk, personal fees from Allergy Therapeut., HAL Allergie, Cassella med; and Membership: AeDA, DGHNO, Deutsche Akademie für Allergologie und klinische Immunologie, HNO‐BV, GPA, EAACI. Funding Information: DPreports grants and personal fees from GlaxoSmithKline, personal fees from Menarini, Pliva, Belupo, AbbVie, Novartis, MSD, Chiesi, Revenio, personal fees and non‐financial support from Boehringer Ingelheim, non‐financial support from Philips. Funding Information: OP reports grants and personal fees from ALK‐Abelló, Allergopharma, Stallergenes Greer, HAL Allergy Holding B.V./HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools S.A., Laboratorios LETI/LETI Pharma, Anergis S.A., Glaxo Smith Kline, grants from Biomay, Circassia, Pohl‐Boskamp, Inmunotek S.L., personal fees from MEDA Pharma/MYLAN, Mobile Chamber Experts (a GA2LEN Partner), Indoor Biotechnologies, Astellas Pharma Global, EUFOREA, ROXALL Medizin, Novartis, Sanofi‐Aventis and Sanofi‐Genzyme, Med Update Europe GmbH, streamedup! GmbH, John Wiley and Sons, AS. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. publishersversion published
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12. Bronchodilator response and lung function decline:Associations with exhaled nitric oxide with regard to sex and smoking status
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Thorainn Gislasson, Angelo Corsico, Simone Accordini, Dennis Nowak, Joost Weyler, Rune Nielsen, Össur Ingi Emilsson, Isabelle Pin, Deborah Jarvis, Vivi Schlunnsen, Elisabet Nerpin, Francisco Gómez Real, Christer Janson, José Antonio Gullón, Diogenes S. Ferreira, Giulia Squillacioti, Andrei Malinovschi, Joachim Heinrich, Rain Jõgi, Ane Johannessen, Anna-Carin Olin, Bertil Forsberg, Chantal Raherison Semjen, Antonio Pereira-Vega, Alessandro Marcon, Pascal Demoly, Isabel Urrutia, Judith Garcia-Aymerich, Mario Olivieri, Commission of the European Communities, Uppsala University, Dalarna University, School of Public Health and Preventive Medicine [Melbourne, Australia], Universidade Federal do Parana [Curitiba] (UFPR), Universidade Federal do Paraná (UFPR), University of Antwerp (UA), Aarhus University [Aarhus], Tartu University Hospital [Tartu, Estonia], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Landspitali National University Hospital of Iceland, University of Iceland [Reykjavik], CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Université de Montpellier (UM), Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Ludwig-Maximilians University [Munich] (LMU), German Research Center for Environmental Health - Helmholtz Center München (GmbH), University of Melbourne, German Center for Lung Research, Foundation IRCCS Policlinico San Matteo, University of Pavia, University of Verona (UNIVR), University of Turin, Haukeland University Hospital, University of Bergen (UiB), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Galdakao Hospital, Hospital Juan Ramón Jiménez, University of Gothenburg (GU), Umeå University, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and Imperial College London
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,medicine.drug_class ,Bronchodilatation ,Epidemiology ,FeNO ,Lung function ,Respiratory Medicine and Allergy ,Immunology ,Article ,03 medical and health sciences ,FEV1/FVC ratio ,0302 clinical medicine ,Bronchodilator ,Internal medicine ,medicine ,Immunology and Allergy ,030223 otorhinolaryngology ,Respiratory health ,Asthma ,Lungmedicin och allergi ,business.industry ,1103 Clinical Sciences ,RC581-607 ,respiratory system ,medicine.disease ,3. Good health ,respiratory tract diseases ,030228 respiratory system ,Feno ,Lung Function ,Exhaled nitric oxide ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Smoking status ,Human medicine ,Immunologic diseases. Allergy ,business - Abstract
Background: Fractional exhaled nitric oxide (FeNO) is a marker of type-2 inflammation used both to support diagnosis of asthma and follow up asthma patients.The associations of FeNO with lung function decline and bronchodilator (BD) response have been studied only scarcely in large populations. Objectives: To study the association between FeNO and a) retrospective lung function decline over 20 years, and b) lung function response to BD among asthmatic subjects compared with non-asthmatic subjects and with regards to current smoking and sex. Methods: Longitudinal analyses of previous lung function decline and FeNO level at follow-up and cross-sectional analyses of BD response and FeNO levels in 4257 participants (651 asthmatics) from the European Community Respiratory Health Survey. Results: Among asthmatic subjects, higher percentage declines of FEV1 and FEV1/FVC were associated with higher FeNO levels (p¼0.001 for both) at follow-up. These correlations were found mainly among non-smoking individuals (p ¼ 0.001) and females (p ¼ 0.001) in stratified analyses. Percentage increase in FEV1 after BD was positively associated with FeNO levels in non-asthmatic subjects. Further, after stratified for sex and smoking separately, a positive association was seen between FEV1 and FeNO levels in non-smokers and women, regardless of asthma status. Conclusions: We found a relationship between elevated FeNO and larger FEV1 decline over 20 years among subjects with asthma who were non-smokers or women. The association between elevated FeNO levels and larger BD response was found in both non-asthmatic and asthmatic subjects, mainly in women and non-smoking subjects. The coordination of ECRHS III was supported by the Medical Research Council (Grant Number 92091).We acknowledge support from the Spanish Ministry of Science and Innovation through the “Centro de Excelencia Severo Ochoa 2019-2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program.
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13. Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European MigraineHeadache Alliance
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Sacco S., Lampl C., Maassen van den Brink A., Caponnetto V., Braschinsky M., Ducros A., Little P., Pozo-Rosich P., Reuter U., Ruiz de la Torre E., Sanchez Del Rio M., Sinclair A. J., Martelletti P., Katsarava Z., Cakciri G., Djamandi P., Grabova S., Halili G., Kruja J., Kuqo A., Naco D., Quka A., Stefanidhi L., Vyshka G., Zekja I., Bruera O., Gomez D., Guitian B., Roma J. C., Chen I. L., Bashirova S., Linkov M., Van Den Abbeele D., Vanderschueren G., Araujo R., Arruda R., Catharino A., Ciriaco J., Dalla Corte A., Dornas R., Felsenfeld B., Fonseca Taufner A., Fragoso Y., Hurtado R., Isoni Martins D., Londero R., Melo L., Mignoni K. S., Sgobbi De Souza P. V., Souza M. N., Osman S., Baltzer V., Pacheco Mosquera L. F., Dubroja I., Hucika Z., Lisak M., Lovrencic-Huzjan A., Lusic I., Mahovic Lakusic D., Mikulenka P., Rehulka P., Amin F. M., Antic S., Fakhril-Din Z., Moeller-Hansen J., Munksgaard S., Nan A. M., Pellesi L., Schytz H., Vides M., Braschinsky K., Krikmann U., Roos C., Cauchie A., Christian L., Guegan-Massardier E., Demarquay G., Gilles G., Mawet J., Kuhn E., Lanteri Minet M., Bustuchina Vlaicu M., Moisset X., Muresan M., Najjar-Ravan M., Giraud P., Simonin S., De Gaalon S., Chakhava G., Demuria M., Gegelashvili G., Kapanadze N., Antonakakis A., Gaul C., Forderreuther S., Huhn J. -I., Ibragimov S., Kamm K., Raffaelli B., Czaniera R., Ruscheweyh R., Gavanozi E., Karagiorgis G., Mavridism T., Ertsey C., Shubham D., Callista Tanowi A. D., Erdana Putra S., Hadi D. W., Kurnia L., Nasrul M., Albanese M., Antonaci F., Asioli G. M., Baschi R., Bentivegna E., Brunelli N., Caratozzolo S., Catarci T., Cherchi A., Corbelli I., Costa A., De Luca C., Doretti A., Favoni V., Ghiotto N., Giamberardino M. A., Giani L., Zanchin G., Govone F., Grillo G., Mampreso E., Negro A., Ornello R., Pasculli M., Pensato U., Prudenzano M. P. A., Quintana S., Rapisarda R., Romoli M., Russo A., Russo M., Spuntarelli V., Tiseo C., Torrente A., Vacca A., Vaula G., Vigano A., Vigneri S., Freimane A., Slosberga E., Zvaune L., Tan H. J., Fenech C., Cobilt-Catana R., De La Garza Neme Y., Martinez M., Proano Narvaez J. V., Rodriguez Herrera A., Vazquez D., Grosu O., Jakupi A., Kristoffersen E. S., Tronvik E., Winsvold B. S., Azhar M., Reyes Alvarez M. T., Vilchez Fernandez L., Dayrit G. D., Czapinska-Ciepiela E. K., Fila M., Gryglas-Dworak A., Couto M., Esperanca P., Ferreira A., Gil-Gouveia R., Goncalves A., Lopes M., Lourenco M., Machado J., Marinho M., Miranda M. A., Palavra F., Parreira E., Pavao Martins I., Pereira L., Pereira Monteiro J. M., Leahu P., Aloman S., Abramova E., Akhmadeeva L., Belopasova A., Bogdanova I., Chernyak M., Epifanova M., Fedorova E., Felbush A., Karpova M., Korobkova D., Korotkova D., Latysheva N., Makeeva T., Mikhalkina K., Osipova V., Roshchina O., Serga A., Serousova O. V., Sidorova Y., Skiba I., Skorobogatykh K., Vashchenko N., Apostolski S., Buder N., Kopitovic A., Mirjana J., Podgorac A., Rakic D., Simic S., Zarko M., Trajkovic J. Z., Beltran-Blasco I., Calabria Gallego M. D., Diaz Insa S., Ezpeleta D., Fernandez M., Garcia-Azorin D., Gonzalez-Garcia N., Guerrero A. L., Guillamon E., Herreros Rodriguez J., Layos-Romero A., Medrano V., Minguez-Olaondo A., Navarro Munoz S., Pare Curell M., Ruibal M., Sanchez Alvarez J. M., Santos S., Soler R., Viguera J., Zabalza R., Abdelrahman T., Abobaker Hamza S. B., Mustafa M. N., Edvinsson L., Gantenbein A., Maraffi I., Couturier E., Dirkx T., Hoebert M., Van Oosterhout W., Wim M., Zwartbol R., Bakir M., Demirel H., Erdemoglu A. K., Ertem D. H., Gonullu S., Ilgaz Aydinlar E., Inan L. E., Olmez B., Ozbenli T., Ozge A., Uluduz D., Uyar Cankay T., Yalinay Dikmen P., Saxena A. B., Bozhenko M., Bozhenko N., Bubnov R., Tsurkalenko O., Abu-Arafeh I., Idrovo L., Miller S., Nirmalananthan N., Sinclair A., Taleti E., Valori A., Whitehouse W., Zermansky A., Thura M., Institut Català de la Salut, [Sacco S, Caponnetto V] Neuroscience section – Department of Biotechnological and Applied Clinical Sciences and (Edificio Coppito 2), University of L’Aquila, Via Vetoio, 67100 L’Aquila, Italy. Regional Referral Headache Center of the Abruzzo Region, ASL Avezzano-Sulmona-L’Aquila, L’Aquila, Italy. [Lampl C] Department of Neurology, Headache Medical Centre Linz, Hospital Barmherzige Brüder, Centre of Integrative Medicine (ZiAM) Ordensklinikum Linz, Linz, Austria. [Maassen van den Brink A] Division of Pharmacology, Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. [Braschinsky M] Headache Clinic, Department of Neurology, Tartu University Clinics, Tartu, Estonia. [Ducros A] Headache Unit, Neurology Department, Montpellier University Hospital and Montpellier University, Montpellier, France. [Pozo-Rosich P] Unitat de Cefalea, Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup d'Investigació en Cefalees i Dolors Neurològics, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus, Sacco, S., Lampl, C., Maassen van den Brink, A., Caponnetto, V., Braschinsky, M., Ducros, A., Little, P., Pozo-Rosich, P., Reuter, U., Ruiz de la Torre, E., Sanchez Del Rio, M., Sinclair, A. J., Martelletti, P., Katsarava, Z., Cakciri, G., Djamandi, P., Grabova, S., Halili, G., Kruja, J., Kuqo, A., Naco, D., Quka, A., Stefanidhi, L., Vyshka, G., Zekja, I., Bruera, O., Gomez, D., Guitian, B., Roma, J. C., Chen, I. L., Bashirova, S., Linkov, M., Van Den Abbeele, D., Vanderschueren, G., Araujo, R., Arruda, R., Catharino, A., Ciriaco, J., Dalla Corte, A., Dornas, R., Felsenfeld, B., Fonseca Taufner, A., Fragoso, Y., Hurtado, R., Isoni Martins, D., Londero, R., Melo, L., Mignoni, K. S., Sgobbi De Souza, P. V., Souza, M. N., Osman, S., Baltzer, V., Pacheco Mosquera, L. F., Dubroja, I., Hucika, Z., Lisak, M., Lovrencic-Huzjan, A., Lusic, I., Mahovic Lakusic, D., Mikulenka, P., Rehulka, P., Amin, F. M., Antic, S., Fakhril-Din, Z., Moeller-Hansen, J., Munksgaard, S., Nan, A. M., Pellesi, L., Schytz, H., Vides, M., Braschinsky, K., Krikmann, U., Roos, C., Cauchie, A., Christian, L., Guegan-Massardier, E., Demarquay, G., Gilles, G., Mawet, J., Kuhn, E., Lanteri Minet, M., Bustuchina Vlaicu, M., Moisset, X., Muresan, M., Najjar-Ravan, M., Giraud, P., Simonin, S., De Gaalon, S., Chakhava, G., Demuria, M., Gegelashvili, G., Kapanadze, N., Antonakakis, A., Gaul, C., Forderreuther, S., Huhn, J. -I., Ibragimov, S., Kamm, K., Raffaelli, B., Czaniera, R., Ruscheweyh, R., Gavanozi, E., Karagiorgis, G., Mavridism, T., Ertsey, C., Shubham, D., Callista Tanowi, A. D., Erdana Putra, S., Hadi, D. W., Kurnia, L., Nasrul, M., Albanese, M., Antonaci, F., Asioli, G. M., Baschi, R., Bentivegna, E., Brunelli, N., Caratozzolo, S., Catarci, T., Cherchi, A., Corbelli, I., Costa, A., De Luca, C., Doretti, A., Favoni, V., Ghiotto, N., Giamberardino, M. A., Giani, L., Zanchin, G., Govone, F., Grillo, G., Mampreso, E., Negro, A., Ornello, R., Pasculli, M., Pensato, U., Prudenzano, M. P. A., Quintana, S., Rapisarda, R., Romoli, M., Russo, A., Russo, M., Spuntarelli, V., Tiseo, C., Torrente, A., Vacca, A., Vaula, G., Vigano, A., Vigneri, S., Freimane, A., Slosberga, E., Zvaune, L., Tan, H. J., Fenech, C., Cobilt-Catana, R., De La Garza Neme, Y., Martinez, M., Proano Narvaez, J. V., Rodriguez Herrera, A., Vazquez, D., Grosu, O., Jakupi, A., Kristoffersen, E. S., Tronvik, E., Winsvold, B. S., Azhar, M., Reyes Alvarez, M. T., Vilchez Fernandez, L., Dayrit, G. D., Czapinska-Ciepiela, E. K., Fila, M., Gryglas-Dworak, A., Couto, M., Esperanca, P., Ferreira, A., Gil-Gouveia, R., Goncalves, A., Lopes, M., Lourenco, M., Machado, J., Marinho, M., Miranda, M. A., Palavra, F., Parreira, E., Pavao Martins, I., Pereira, L., Pereira Monteiro, J. M., Leahu, P., Aloman, S., Abramova, E., Akhmadeeva, L., Belopasova, A., Bogdanova, I., Chernyak, M., Epifanova, M., Fedorova, E., Felbush, A., Karpova, M., Korobkova, D., Korotkova, D., Latysheva, N., Makeeva, T., Mikhalkina, K., Osipova, V., Roshchina, O., Serga, A., Serousova, O. V., Sidorova, Y., Skiba, I., Skorobogatykh, K., Vashchenko, N., Apostolski, S., Buder, N., Kopitovic, A., Mirjana, J., Podgorac, A., Rakic, D., Simic, S., Zarko, M., Trajkovic, J. Z., Beltran-Blasco, I., Calabria Gallego, M. D., Diaz Insa, S., Ezpeleta, D., Fernandez, M., Garcia-Azorin, D., Gonzalez-Garcia, N., Guerrero, A. L., Guillamon, E., Herreros Rodriguez, J., Layos-Romero, A., Medrano, V., Minguez-Olaondo, A., Navarro Munoz, S., Pare Curell, M., Ruibal, M., Sanchez Alvarez, J. M., Santos, S., Soler, R., Viguera, J., Zabalza, R., Abdelrahman, T., Abobaker Hamza, S. B., Mustafa, M. N., Edvinsson, L., Gantenbein, A., Maraffi, I., Couturier, E., Dirkx, T., Hoebert, M., Van Oosterhout, W., Wim, M., Zwartbol, R., Bakir, M., Demirel, H., Erdemoglu, A. K., Ertem, D. H., Gonullu, S., Ilgaz Aydinlar, E., Inan, L. E., Olmez, B., Ozbenli, T., Ozge, A., Uluduz, D., Uyar Cankay, T., Yalinay Dikmen, P., Saxena, A. B., Bozhenko, M., Bozhenko, N., Bubnov, R., Tsurkalenko, O., Abu-Arafeh, I., Idrovo, L., Miller, S., Nirmalananthan, N., Sinclair, A., Taleti, E., Valori, A., Whitehouse, W., Zermansky, A., Thura, M., and Internal Medicine
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Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,medicine.medical_specialty ,Pediatrics ,Neurology ,Consensus ,enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos con cefaleas::cefaleas primarias::trastornos migrañosos [ENFERMEDADES] ,migraine ,migraine care ,refractory migraine ,resistant migraine ,consensus ,cross-sectional studies ,headache ,humans ,surveys and questionnaires ,migraine disorders ,Pain medicine ,Moderate confidence ,Migraine Disorders ,Medizin ,Consensu ,Migranya - Tractament ,Qüestionaris ,Refractory ,Surveys and Questionnaires ,medicine ,Surveys and Questionnaire ,Humans ,Clinical significance ,Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Headache Disorders::Headache Disorders, Primary::Migraine Disorders [DISEASES] ,Otros calificadores::/terapia [Otros calificadores] ,Migraine ,Cross-Sectional Studie ,business.industry ,Headache ,técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,General Medicine ,Other subheadings::/therapy [Other subheadings] ,medicine.disease ,Refractory migraine ,Anesthesiology and Pain Medicine ,Cross-Sectional Studies ,Burden ,Medicine ,Neurology (clinical) ,Level of care ,business ,Resistant migraine ,Migraine care ,Human ,Research Article - Abstract
Background New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. There is the need of homogenous criteria to identify candidates for treatment escalation as well as of reliable criteria to identify refractoriness to treatment. To overcome those issues, the European Headache Federation (EHF) issued a Consensus document to propose criteria to approach difficult-to-treat migraine patients in a standardized way. The Consensus proposed well-defined criteria for resistant migraine (i.e., patients who do not respond to some treatment but who have residual therapeutic opportunities) and refractory migraine (i.e., patients who still have debilitating migraine despite maximal treatment efforts). The aim of this study was to better understand the perceived impact of resistant and refractory migraine and the attitude of physicians involved in migraine care toward those conditions. Methods We conducted a web-questionnaire-based cross-sectional international study involving physicians with interest in headache care. Results There were 277 questionnaires available for analysis. A relevant proportion of participants reported that patients with resistant and refractory migraine were frequently seen in their clinical practice (49.5% for resistant and 28.9% for refractory migraine); percentages were higher when considering only those working in specialized headache centers (75% and 46% respectively). However, many physicians reported low or moderate confidence in managing resistant (8.1% and 43.3%, respectively) and refractory (20.7% and 48.4%, respectively) migraine patients; confidence in treating resistant and refractory migraine patients was different according to the level of care and to the number of patients visited per week. Patients with resistant and refractory migraine were infrequently referred to more specialized centers (12% and 19%, respectively); also in this case, figures were different according to the level of care. Conclusions This report highlights the clinical relevance of difficult-to-treat migraine and the presence of unmet needs in this field. There is the need of more evidence regarding the management of those patients and clear guidance referring to the organization of care and available opportunities.
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- 2021
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14. Cumulative Occupational Exposures and Lung Function Decline in Two Large General Population Cohorts
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Josep M. Antó, Deborah Jarvis, Roberto Bono, Simona Villani, Dennis Nowak, Hayat Bentouhami, Jan Paul Zock, Bénédicte Leynaert, Theodore Lytras, Kjell Torén, Isabel Urrutia, Joachim Heinrich, Bertil Forsberg, Isabelle Pin, Joost Weyler, Chantal Raherison Semjen, Jesús Martínez-Moratalla, Vivi Schlünssen, Giulia Squillacioti, Dirk Keidel, Nicole Probst-Hensch, Øistein Svanes, Torben Sigsgaard, Rain Jõgi, Pascal Demoly, Mathias Holm, Paul D. Blanc, Antonio Pereira Vega, John Watkins, Mario Olivieri, Amar Mehta, Anne-Elie Carsin, Anna Beckmeyer-Borowko, David Vernez, Thorarinn Gislason, Dan Norbäck, Roel Vermeulen, José Antonio Gullón, Manolis Kogevinas, Geza Benke, A. Sonia Buist, Hans Kromhout, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, Utrecht University [Utrecht], University of Antwerp (UA), Klinikum der Universitat Munchen, Ludwig-Maximilians-Universität München (LMU), German Center for Lung Research, Galdakao Hospital, Complejo Hospitalario Universitario de Albacete, Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM), Hospital Juan Ramón Jiménez, Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de médecine aiguë spécialisée, CHU Grenoble-Hôpital Michallon, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli Studi di Pavia = University of Pavia (UNIPV), Landspitali National University Hospital of Iceland, University of Iceland [Reykjavik], University of Bergen (UiB), Sahlgrenska University Hospital [Gothenburg], Umeå University, Uppsala University, University of Copenhagen = Københavns Universitet (UCPH), Université de Lausanne = University of Lausanne (UNIL), Monash University [Melbourne], Tartu University Hospital [Tartu, Estonia], Sahlgrenska Academy at University of Gothenburg [Göteborg], Aarhus University [Aarhus], Università degli studi di Verona = University of Verona (UNIVR), University of California [San Francisco] (UC San Francisco), University of California (UC), Cardiff University, Università degli studi di Torino = University of Turin (UNITO), Oregon Health and Science University [Portland] (OHSU), Imperial College London, and Herrada, Anthony
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longitudinal studies ,lung function ,occupational disease ,occupational exposure ,spirometry ,Vital Capacity ,Spirometry ,Lung function ,Occupational Exposure ,Occupational Disease ,Longitudinal studies ,VENTILATORY FUNCTION ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,MESH: Occupational Exposure ,Cohort Studies ,0302 clinical medicine ,Forced Expiratory Volume ,Medicine ,030212 general & internal medicine ,Lung ,MESH: Cohort Studies ,Original Research ,RISK ,education.field_of_study ,medicine.diagnostic_test ,WORKERS ,Occupational Diseases ,SWISS ,Occupational exposure ,BURDEN ,Adult ,MESH: Occupational Diseases ,Pulmonary and Respiratory Medicine ,MESH: Bayes Theorem ,Population ,AMERICAN THORACIC SOCIETY ,Occupational disease ,MEDLINE ,MESH: Forced Expiratory Volume ,OBSTRUCTIVE PULMONARY-DISEASE ,03 medical and health sciences ,Environmental health ,Humans ,COPD ,MESH: Lung ,education ,MESH: Humans ,business.industry ,Bayes Theorem ,MESH: Adult ,AIR-POLLUTION ,MESH: Vital Capacity ,medicine.disease ,respiratory tract diseases ,030228 respiratory system ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Human medicine ,business ,FOLLOW-UP - Abstract
International audience; Rationale: Few longitudinal studies have assessed the relationship between occupational exposures and lung-function decline in the general population with a sufficiently long follow-up.Objectives: To examine the potential association in two large cohorts: the ECRHS (European Community Respiratory Health Survey) and the SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults).Methods: General-population samples of individuals aged 18 to 62 were randomly selected in 1991-1993 and followed up approximately 10 and 20 years later. Spirometry (without bronchodilation) was performed at each visit. Coded complete job histories during follow-up visits were linked to a job-exposure matrix, generating cumulative exposure estimates for 12 occupational exposures. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were jointly modeled in linear mixed-effects models, fitted in a Bayesian framework, taking into account age and smoking.Results: A total of 40,024 lung-function measurements from 17,833 study participants were analyzed. We found accelerated declines in FEV1 and the FEV1/FVC ratio for exposure to biological dust, mineral dust, and metals (FEV1 = -15.1 ml, -14.4 ml, and -18.7 ml, respectively; and FEV1/FVC ratio = -0.52%, -0.43%, and -0.36%, respectively; per 25 intensity-years of exposure). These declines were comparable in magnitude with those associated with long-term smoking. No effect modification by sex or smoking status was identified. Findings were similar between the ECRHS and the SAPALDIA cohorts.Conclusions: Our results greatly strengthen the evidence base implicating occupation, independent of smoking, as a risk factor for lung-function decline. This highlights the need to prevent or control these exposures in the workplace.
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- 2021
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15. Regulatory landscape of providing information on newborn screening to parents across Europe
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Franková, Věra, Driscoll, Riona O., Jansen, Marleen E., Loeber, J. Gerard, Kožich, Viktor, Bonham, James, Borde, Patricia, Brincat, Ian, Cheillan, David, Dekkers, Eugenie, Fingerhut, Ralph, Kuš, Iva Bilandžija, Girginoudis, Panagiotis, Groselj, Urh, Hougaard, David, Knapková, Mária, la Marca, Giancarlo, Malniece, Ieva, Nanu, Michaela Iuliana, Nennstiel, Uta, Olkhovych, Nataliia, Oltarzewski, Mariusz, Pettersen, Rolf D., Racz, Gabor, Reinson, Karit, Salimbayeva, Damilya, Songailiene, Jurgita, Vilarinho, Laura, Vogazianos, Marios, Zetterström, Rolf H., Zeyda, Maximilian, Members of the European Society of Human Genetics (ESHG)-EuroGentest Quality Sub-Committee, CarMeN, laboratoire, First Faculty of Medicine Charles University [Prague], National Institute for Public Health and the Environment [Bilthoven] (RIVM), International Society for Neonatal Screening Office [Bilthoven, The Netherlands] (ISNSO), Sheffield Children's NHS Foundation Trust, Mater Dei Hospital [Malta], Hospices Civils de Lyon (HCL), University Children’s Hospital Zurich, University Hospital Centre Zagreb, Partenaires INRAE, Institute of Child Health [Athens, Greece], University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Statens Serum Institute [Copenhagen], Matej Bel University (UMB), Children's University Hospital [Banska Bystrica, Slovakia] (CUH-BB), Azienda Ospedaliero Universitaria A. Meyer [Firenze, Italy], Children's Clinical University Hospital [Riga, Latvia] (CCUH), National Institute for Mother & Child Health [Bucharest, Romania] (NIMCH), Bavarian Health and Food Safety Authority [Oberschleißheim, Germany], National Children's Specialized Hospital 'Okhmatdyt' [Kiev, Ukraine] (NCSHO), National Research Institute of Mother and Child [Warsaw, Poland], Oslo University Hospital [Oslo], University of Szeged [Szeged], Tartu University Hospital [Tartu, Estonia], Scientific centre of Gynaecology, Obstetrics and Perinatology [Almaty, Kazakhstan] (SGOP), International Science and Technology Center [Almaty, Kazakhstan] ( ISTC), Vilnius University [Vilnius], Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal] (INSA), Limassol General Hospital, Karolinska University Hospital [Solna, Sweden] (KUH), Medizinische Universität Wien = Medical University of Vienna, Human genetics, and APH - Quality of Care
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Male ,Parents ,European level ,Best practice ,[SDV]Life Sciences [q-bio] ,MEDLINE ,Disclosure ,Guidelines ,Article ,Public healthcare ,03 medical and health sciences ,Neonatal Screening ,0302 clinical medicine ,Surveys and Questionnaires ,030225 pediatrics ,Genetics ,Humans ,European Union ,Genetic Testing ,030212 general & internal medicine ,Genetics (clinical) ,Medical education ,Newborn screening ,Infant, Newborn ,food and beverages ,Organizational Policy ,3. Good health ,Doenças Genéticas ,Europe ,[SDV] Life Sciences [q-bio] ,Practice Guidelines as Topic ,embryonic structures ,Female ,Sample collection ,Business ,Newborn Screening - Abstract
Newborn screening (NBS) is an important part of public healthcare systems in many countries. The provision of information to parents about NBS is now recognised as an integral part of the screening process. Informing parents on all aspects of screening helps to achieve the benefits, promote trust and foster support for NBS. Therefore, policies and guidelines should exist to govern how the information about NBS is provided to parents, taking into account evidence-based best practices. The purpose of our survey was to explore whether any legally binding provisions, guidelines or recommendations existed pertaining to the provision of information about NBS to parents across Europe. Questions were designed to determine the regulatory process of when, by whom and how parents should be informed about screening. Twenty-seven countries participated in the survey. The results indicated that most countries had some sort of legal framework or guidelines for the provision of information to parents. However, only 37% indicated that the provision of information was required prenatally. The majority of countries were verbally informing parents with the aid of written materials postnatally, just prior to sample collection. Information was provided by a neonatologist, midwife or nurse. A website dedicated to NBS was available for 67% of countries and 89% had written materials about NBS for parents. The survey showed that there is a lack of harmonisation among European countries in the provision of information about NBS and emphasised the need for more comprehensive guidelines at the European level. Institutional support was provided by projects LM2018132 from the Large Infrastructure Projects of the Czech Ministry of Education, PROGRES Q26 from Charles University and RVO VFN 64165 from the Ministry of Health, Czech Republic. Several authors of this publication are members of the European Reference Network for Rare Hereditary Metabolic Disorders (MetabERN)—Project ID No. 739543. info:eu-repo/semantics/publishedVersion
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- 2021
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16. Identification of Papillary Patterns in Human Fingers and Toes on the Basis of General Characteristics
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Aelita Zīle, Annika Lall, Silvia Kaugia, University of Tartu, Estonia, Retired Police Lieutenant Colonel, Estonia, and Rīga Stradiņš University, Faculty of Law, Latvia
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Basis (linear algebra) ,business.industry ,Computer science ,Pattern recognition ,body regions ,papillary ridge patterns of the skin ,general features ,Microsil® ,comparison ,fingers ,Identification (biology) ,Artificial intelligence ,toes ,business - Abstract
The article gives a brief overview of the types of papillary ridge patterns of the skin, their location on the digits of fingers and toes. In this study, the authors of the article aimed to determine whether the papillary ridge patterns of a person’s fingers and toes on the hands and feet of the same side are identical in terms of general characteristics. The methods used were the printing ink imprints on dactyloscopic maps and Microsil® impressions, and the comparison of the obtained impressions. This research is funded by the Latvian-Ukrainian Joint Programme of Scientific and Technological Cooperation Project (2021) "Open Educational Resource: Forensic Science”, Project No. LV-UA/2021/3.
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- 2021
17. Cohort profile : effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort
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Zeitlin, J, Maier, RF, Cuttini, M, Aden, U, Boerch, K, Gadzinowski, J, Jarreau, P-H, Lebeer, J, Norman, M, Pedersen, P, Petrou, S, Pfeil, JM, Toome, L, van Heijst, A, van Reempts, P, Varendi, H, Barros, H, Groups, EPICE and SHIPS Research, Sarrechia, Iemke, EPICE Reseach Group, SHIPS Research Group, Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), DHU Risques Et Grossesse, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Philipps Universität Marburg = Philipps University of Marburg, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Department of Women's and Children's Health [Stockholm, Sweden], Karolinska University Hospital [Stockholm], Copenhagen University Hospital Hvidovre [Hvidovre, Danemark], University of Copenhagen = Københavns Universitet (UCPH), Poznan University of Medical Sciences [Poland] (PUMS), Department of Primary & Interdisciplinary Care, Disability Studies [Antwerpen, Belgium] (Faculty of Medicine), University of Antwerp (UA), Department of Clinical Science, Intervention and Technology [Stockholm, Sweden], Karolinska Institutet [Stockholm], Aalborg University [Denmark] (AAU), Warwick Medical School, University of Warwick [Coventry], Nuffield Department of Primary Care Health Sciences, University of Oxford, University of Oxford, European Foundation for the Care of Newborn Infants [Munich, Germany] (EFCNI), Tallinn Children's Hospital [Tallinn, Estonia], University of Tartu, Radboud University Medical Center [Nijmegen], Antwerp University Hospital [Edegem] (UZA), Study Centre for Perinatal Epidemiology [Brussels, Belgium] (SCPE), Tartu University Hospital [Tartu, Estonia], Instituto de Saúde Pública da Universidade do Porto [Porto, Portugal] (ISPUP), Universidade do Porto = University of Porto, University of Leicester, EPICE and SHIPS Research Group: J Lebeer, P Van Reempts, E Bruneel, E Cloet, A Oostra, E Ortibus, I Sarrechia, K Boerch, L Huusom, P Pedersen, T Weber, L Toome, H Varendi, M Männamaa, P Y Ancel, A Burguet, P H Jarreau, V Pierrat, P Truffert, R F Maier, M Zemlin, B Misselwitz, S Schmidt, L Wohlers, M Cuttini, D Di Lallo, G Ancora, D Baronciani, V Carnielli, I Croci, G Faldella, F Ferrari, F Franco, G Gargano, A van Heijst, C Koopman-Esseboom, J Gadzinowski, J Mazela, A Montgomery, T Pikuła, H Barros, R Costa, L Mendes Graça, M do Céu Machado, C Rodrigues, T Rodrigues, U Aden, A K Edstedt Bonamy, M Norman, E S Draper, E M Boyle, A Fenton, S J Johnson, B N Manktelow, D W A Milligan, S Mader, N Thiele, J M Walz, S Petrou, J Zeitlin, M Bonet, C Bonnet, R El Raffei, A Piedvache, A V Seppanen, PHILIBERT, Marianne, Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Philipps University of Marburg, University of Copenhagen = Københavns Universitet (KU), University of Oxford [Oxford], and Universidade do Porto
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Critical Care ,[SDV]Life Sciences [q-bio] ,Infant, Newborn ,Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] ,Cohort Studies ,Europe ,[SDV] Life Sciences [q-bio] ,Perinatal Care ,Treatment Outcome ,Pregnancy ,Infant, Extremely Premature ,Humans ,Premature Birth ,Female ,Human medicine ,Cohort Profiles ,ComputingMilieux_MISCELLANEOUS - Abstract
Contains fulltext : 220753.pdf (Publisher’s version ) (Open Access)
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- 2020
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18. International severe asthma registry (ISAR): protocol for a global registry
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Eileen Wang, Trung N. Tran, Marianna Alacqua, Todor A. Popov, Ruth Murray, George Christoff, Lauri Lehtimäki, Chris A. Price, Mohsen Sadatsafavi, James Zangrilli, Naeimeh Hosseini, Andrew Menzies-Gow, John Busby, Luis Perez-de-Llano, Mariko Siyue Koh, Unnur S. Bjornsdottir, Guy Brusselle, Paul E Pfeffer, Vibeke Backer, Michael E. Wechsler, Mark Hew, Anke H. Maitland-van der Zee, Peter G. Gibson, Alan Altraja, Lakmini Bulathsinhala, Dora Ludviksdottir, Celeste Porsbjerg, Liam G Heaney, Richard W. Costello, Enrico Heffler, Rupert Jones, Leif Bjermer, Yuji Tohda, Borja G. Cosío, Nikolaos G. Papadopoulos, J. Mark FitzGerald, Giorgio Walter Canonica, Chin Kook Rhee, Victoria Carter, Neva Eleangovan, Takashi Iwanaga, Isha Chaudhry, You Sook Cho, Arnaud Bourdin, Matthew J. Peters, David Price, Thao Le, David A. Jackson, Epidemiology, Pulmonary Medicine, The Lung Centre Vancouver General Hospital, UBC Institute for Heart and Lung Health, Vancouver, BC, AstraZeneca, Gaithersburg, MD, USA, AstraZeneca, Luton, United Kingdom of Great Britain and Northern Ireland., Department of Pulmonary Medicine, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia, Center of Physical Activity Research, Rigshospitalet and Copenhagen University, Copenhagen, Denmark., Department of Respiratory Medicine & Allergology, Skåne University Hospital, Lund, Sweden, Faculty of Medicine, University of Iceland, Reykjavik, Iceland, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Ghent University Hospital, Humanitas Clinical and Research Center [Rozzano, Milan, Italy], Queen's University [Belfast] (QUB), Dipartimento di Scienze Mediche, Università degli studi di Torino (UNITO), Department of Electrical and Computer Engineering [Houston], University of Houston, Royal Brompton Hospital, Lung Division, London, United Kingdom of Great Britain and Northern Ireland., MedScript Ltd, UPC Research Laboratories, Allergy Department, Institute for Nuclear Research and Nuclear Energy (INRNE), Académie des sciences de Bulgarie, Aberystwyth University, Division of Infection and Immunity, School of Medicine [Cardiff], Cardiff University-Institute of Medical Genetics [Cardiff]-Cardiff University-Institute of Medical Genetics [Cardiff], Tampere University, Department of Respiratory medicine, Dermatology and Allergology, Clinical Medicine, Pulmonology, Paediatric Pulmonology, AII - Inflammatory diseases, APH - Personalized Medicine, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, and University of Iceland
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Severe asthma ,Epidemiology ,[SDV]Life Sciences [q-bio] ,Delphi method ,Health informatics ,0302 clinical medicine ,DESIGN ,Health care ,Medicine and Health Sciences ,Protocol ,Registries ,030212 general & internal medicine ,ComputingMilieux_MISCELLANEOUS ,lcsh:R5-920 ,OUTCOMES ,education.field_of_study ,030503 health policy & services ,Pharmacoepidemiology ,Astmi ,3142 Public health care science, environmental and occupational health ,3. Good health ,SAFETY ,Medical emergency ,lcsh:Medicine (General) ,0305 other medical science ,Research Article ,Adult ,Adolescent ,Population ,PHENOTYPES ,Health Informatics ,03 medical and health sciences ,Disease registry ,Skráning gagna ,Pharmacovigilance ,medicine ,Humans ,education ,Disease burden ,TO-TREAT ASTHMA ,MEPOLIZUMAB ,business.industry ,medicine.disease ,Asthma ,EXACERBATIONS ,DEFINITION ,Real-world ,HEALTH-CARE ,business ,COSTS - Abstract
Publisher's version (útgefin grein), Background: Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical features and outcomes of severe asthma in order to facilitate personalised and targeted care. The International Severe Asthma Registry (ISAR) is a multi-country registry project initiated to aid in this endeavour. Methods: ISAR is a multi-disciplinary initiative benefitting from the combined experience of the ISAR Steering Committee (ISC; comprising 47 clinicians and researchers across 29 countries, who have a special interest and/or experience in severe asthma management or establishment and maintenance of severe asthma registries) in collaboration with scientists and experts in database management and communication. Patients (=18 years old) receiving treatment according to the 2018 definitions of the Global Initiative for Asthma (GINA) Step 5 or uncontrolled on GINA Step 4 treatment will be included. Data will be collected on a core set of 95 variables identified using the Delphi method. Participating registries will agree to provide access to and share standardised anonymous patient-level data with ISAR. ISAR is a registered data source on the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance. ISAR's collaborators include Optimum Patient Care, the Respiratory Effectiveness Group (REG) and AstraZeneca. ISAR is overseen by the ISC, REG, the Anonymised Data Ethics and Protocol Transparency Committee and the ISAR operational committee, ensuring the conduct of ethical, clinically relevant research that brings value to all key stakeholders. Conclusions: ISAR aims to offer a rich source of real-life data for scientific research to understand and improve disease burden, treatment patterns and patient outcomes in severe asthma. Furthermore, the registry will provide an international platform for research collaboration in respiratory medicine, with the overarching aim of improving primary and secondary care of adults with severe asthma globally., The International Severe Asthma Registry is conducted by Optimum Patient Care Global Limited, and co-funded by Optimum Patient Care Global Limited and AstraZeneca. ISAR is supported by grants from AstraZeneca and Optimum Patient Care (OPC) Global (a not-for-profit social enterprise). The ISAR steering committee (ISC) was involved in the development of the protocol and is responsible for approving research proposals via a democratic voting process. In addition to 47 clinicians and researchers with an interest and experience in severe asthma, the ISC also includes members of OPC and four medical experts from AstraZeneca. AstraZeneca reviewed the draft before submission; however, decision to submit was made by the authors. Medical writing support was funded by AstraZeneca in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3).
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19. Organization of intensive cardiac care units in Europe: Results of a multinational survey
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C Hassenger, Michael Koutouzis, M Sivagowry Rasalingam, Marek Gierlotka, J Belohlavev, Christophe Beauloye, Nikolaos Nikolaou, Gianni Casella, N Radovanovic, Zaza Iakobishvili, Marija Vavlukis, Eric Bonnefoy, E Trendafilova, M Lettino, Holger Thiele, Diana Tint, L. de Luca, K Daly, François Roubille, I Zakke, S Monteiro, Pranas Šerpytis, R Zukermann, Ahmed Magdy, Toomas Marandi, C Held, Zdravko Babić, Marc J. Claeys, D Arroyo, Alessandro Sionis, Susanna Price, Department of Cardiology, Antwerp University Hospital, Belgium. 2, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Department of Cardiology, Ospedale Maggiore, Italy, Rambam Medical Health Center, Israel., National Center for Scientific Research 'Demokritos' (NCSR), Università degli Studi di Sassari [Sassari] (UNISS), Department of Cardiology, University of Opole, Poland., Heart Institute, Holon Medical Center, Israel., Heart Center Leipzig, University Hospital, Germany, Red Cross General Hospital, Greece, Hospital de la Santa Creu i Sant Pau, Coimbra University Hospital, Portugal, Cliniques Universitaires Saint Luc, UCLouvain, Belgium., Department of Medical Sciences, Uppsala Clinical Research Center, Sweden, ICCO Clinics, Transilvania University, Romania., Pauls Stradins Clinical University Hospital, Latvia, Faculty of Medicine, Vilnius University, Lithuania, University Hospital Centre, Sisters of Mercy, Croatia, 2nd Department of Medicine, Charles University, Czech Republic., National Heart Institution, Egypt., Department of Cardiology, Aarhus University Hospital, Denmark., Teagasc - The Agriculture and Food Development Authority (Teagasc), University College Hospital, Ireland, Hôpital Cantonal Fribourg, Switzerland., PHO University Clinic of Cardiology, Macedonia., Clinical Center of Serbia, Emergency Center, Serbia., ICCU, National Cardiology Hospital, Bulgaria, North Estonia Medical Centre, Department of Cardiology, University of Tartu, Estonia, Department of Cardiology, Rigshospitalet, Denmark, Department of Clinical Medicine, University of Copenhagen, Denmark, Division of Cardiology, San Gerardo Hospital, Italy, Adult Intensive Care Unit, Royal Brompton Hospital, London., Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Intensive Cardiac Care Unit, Hospices Civils de Lyon, France., Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Charles University [Prague] (CU), University of Tartu, University of Copenhagen = Københavns Universitet (UCPH), and MORNET, Dominique
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Heart Diseases ,[SDV]Life Sciences [q-bio] ,education ,030204 cardiovascular system & hematology ,Critical Care and Intensive Care Medicine ,Unit (housing) ,03 medical and health sciences ,0302 clinical medicine ,Patient Admission ,Risk Factors ,acute cardiovascular care ,Surveys and Questionnaires ,Severity of illness ,Medicine ,Humans ,030212 general & internal medicine ,health care economics and organizations ,business.industry ,Intensive cardiac care unit ,General Medicine ,organization ,medicine.disease ,TRENDS ,EVOLUTION ,Europe ,[SDV] Life Sciences [q-bio] ,Intensive Care Units ,Cardiac Care Facilities ,Multinational corporation ,PATTERNS ,Medical emergency ,Human medicine ,admission policy ,Morbidity ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: The present survey aims to describe the intensive cardiac care unit organization and admission policies in Europe. Methods: A total of 228 hospitals (61% academic) from 27 countries participated in this survey. In addition to the organizational aspects of the intensive cardiac care units, including classification of the intensive cardiac care unit levels, data on the admission diagnoses were gathered from consecutive patients who were admitted during a two-day period. Admission policies were evaluated by comparing illness severity with the intensive cardiac care unit level. Gross national income was used to differentiate high-income countries (n=13) from middle-income countries (n=14). Results: A total of 98% of the hospitals had an intensive cardiac care unit: 70% had a level 1 intensive cardiac care unit, 76% had a level 2 intensive cardiac care unit, 51% had a level 3 intensive cardiac care unit, and 60% of the hospitals had more than one intensive cardiac care unit level. High-income countries tended to have more level 3 intensive cardiac care units than middle-income countries (55% versus 41%, p=0.07). A total of 5159 admissions were scored on illness severity: 63% were low severity, 24% were intermediate severity, and 12% were high severity. Patients with low illness severity were predominantly admitted to level 1 intensive cardiac care units, whereas patients with high illness severity were predominantly admitted to level 2 and 3 intensive cardiac care units. A policy mismatch was observed in 12% of the patients; some patients with high illness severity were admitted to level 1 intensive cardiac care units, which occurred more often in middle-income countries, whereas some patients with low illness severity were admitted to level 3 intensive cardiac care units, which occurred more frequently in high-income countries. Conclusion: More than one-third of the admitted patients were considered intermediate or high risk. Although patients with higher illness severity were mostly admitted to high-level intensive cardiac care units, an admission policy mismatch was observed in 12% of the patients; this mismatch was partly related to insufficient logistic intensive cardiac care unit capacity.
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20. Auto-antibodies against type I IFNs in patients with life-threatening COVID-19
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Bastard, P., Rosen, L. B., Zhang, Q., Michailidis, E., Hoffmann, H. -H., Zhang, Y., Dorgham, K., Philippot, Q., Rosain, J., Beziat, V., Manry, J., Shaw, E., Haljasmagi, L., Peterson, P., Lorenzo, L., Bizien, L., Trouillet-Assant, S., Dobbs, K., de Jesus, A. A., Belot, A., Kallaste, A., Catherinot, E., Tandjaoui-Lambiotte, Y., Le Pen, J., Kerner, G., Bigio, B., Seeleuthner, Y., Yang, R., Bolze, A., Spaan, A. N., Delmonte, O. M., Abers, M. S., Aiuti, A., Casari, G., Lampasona, V., Piemonti, L., Ciceri, F., Bilguvar, K., Lifton, R. P., Vasse, M., Smadja, D. M., Migaud, M., Hadjadj, J., Terrier, B., Duffy, D., Quintana-Murci, L., van de Beek, D., Roussel, L., Vinh, D. C., Tangye, S. G., Haerynck, F., Dalmau, D., Martinez-Picado, J., Brodin, P., Nussenzweig, M. C., Boisson-Dupuis, S., Rodriguez-Gallego, C., Vogt, G., Mogensen, T. H., Oler, A. J., Gu, J., Burbelo, P. D., Cohen, J. I., Biondi, A., Bettini, L. R., Dangio, M., Bonfanti, P., Rossignol, P., Mayaux, J., Rieux-Laucat, F., Husebye, E. S., Fusco, F., Ursini, M. V., Imberti, L., Sottini, A., Paghera, S., Quiros-Roldan, E., Rossi, C., Castagnoli, R., Montagna, D., Licari, A., Marseglia, G. L., Duval, X., Ghosn, J., Tsang, J. S., Goldbach-Mansky, R., Kisand, K., Lionakis, M. S., Puel, A., Zhang, S. -Y., Holland, S. M., Gorochov, G., Jouanguy, E., Rice, C. M., Cobat, A., Notarangelo, L. D., Abel, L., H. C., Su, Casanova, J. -L., Arias, A. A., Boisson, B., Boucherit, S., Bustamante, J., Chbihi, M., Chen, J., Chrabieh, M., Kochetkov, T., Le Voyer, T., Liu, D., Nemirovskaya, Y., Ogishi, M., Papandrea, D., Patissier, C., Rapaport, F., Roynard, M., Vladikine, N., Woollett, M., Zhang, P., Kashyap, A., Ding, L., Bosticardo, M., Wang, Q., Ochoa, S., Liu, H., Chauvin, S. D., Stack, M., Koroleva, G., Bansal, N., Dalgard, C. L., Snow, A. L., Abad, J., Aguilera-Albesa, S., Akcan, O. M., Darazam, I. A., Aldave, J. C., Ramos, M. A., Nadji, S. A., Alkan, G., Allardet-Servent, J., Allende, L. M., Alsina, L., Alyanakian, M. -A., Amador-Borrero, B., Amoura, Z., Antoli, A., Arslan, S., Assant, S., Auguet, T., Azot, A., Bajolle, F., Baldolli, A., Ballester, M., Feldman, H. B., Barrou, B., Beurton, A., Bilbao, A., Blanchard-Rohner, G., Blanco, I., Blandinieres, A., Blazquez-Gamero, D., Bloomfield, M., Bolivar-Prados, M., Borie, R., Bousfiha, A. A., Bouvattier, C., Boyarchuk, O., Bueno, M. R. P., Agra, J. J. C., Calimli, S., Capra, R., Carrabba, M., Casasnovas, C., Caseris, M., Castelle, M., Castelli, F., de Vera, M. C., Castro, M. V., Chalumeau, M., Charbit, B., Cheng, M. P., Clave, P., Clotet, B., Codina, A., Colkesen, F., Colobran, R., Comarmond, C., Corsico, A. G., Darley, D. R., Dauby, N., Dauger, S., de Pontual, L., Dehban, A., Delplancq, G., Demoule, A., Di Sabatino, A., Diehl, J. -L., Dobbelaere, S., Durand, S., Eldars, W., Elgamal, M., Elnagdy, M. H., Emiroglu, M., Erdeniz, E. H., Aytekin, S. E., Euvrard, R., Evcen, R., Fabio, G., Faivre, L., Falck, A., Fartoukh, M., Faure, M., Arquero, M. F., Flores, C., Francois, B., Fumado, V., Solis, B. G., Gaussem, P., Gil-Herrera, J., Gilardin, L., Alarcon, M. G., Girona-Alarcon, M., Goffard, J. -C., Gok, F., Gonzalez-Montelongo, R., Guerder, A., Gul, Y., Guner, S. N., Gut, M., Halwani, R., Hammarstrom, L., Hatipoglu, N., Hernandez-Brito, E., Holanda-Pena, M. S., Horcajada, J. P., Hraiech, S., Humbert, L., Iglesias, A. D., Inigo-Campos, A., Jamme, M., Arranz, M. J., Jordan, I., Kanat, F., Kapakli, H., Kara, I., Karbuz, A., Yasar, K. K., Keles, S., Demirkol, Y. K., Klocperk, A., Krol, Z. J., Kuentz, P., Kwan, Y. W. M., Lagier, J. -C., Lau, Y. -L., Le Bourgeois, F., Leo, Y. -S., Lopez, R. L., Leung, D., Levin, M., Levy, M., Levy, R., Li, Z., Linglart, A., Lorenzo-Salazar, J. M., Louapre, C., Lubetzki, C., Luyt, C. -E., Lye, D. C., Mansouri, D., Marjani, M., Pereira, J. M., Martin, A., Pueyo, D. M., Marzana, I., Mathian, A., Matos, L. R. B., Matthews, G. V., Mege, J. -L., Melki, I., Meritet, J. -F., Metin, O., Meyts, I., Mezidi, M., Migeotte, I., Millereux, M., Mirault, T., Mircher, C., Mirsaeidi, M., Melian, A. M., Martinez, A. M., Morange, P., Mordacq, C., Morelle, G., Mouly, S., Munoz-Barrera, A., Nafati, C., Neves, J. F., L. F. P., Ng, Medina, Y. N., Cuadros, E. N., Gonzalo Ocejo-Vinyals, J., Orbak, Z., Oualha, M., Ozcelik, T., Hammarstrom, Q. P., Parizot, C., Pascreau, T., Paz-Artal, E., de Diego, R. P., Philippe, A., Philippota, Q., Planas-Serra, L., Ploin, D., Poissy, J., Poncelet, G., Pouletty, M., Quentric, P., Raoult, D., Rebillat, A. -S., Reisli, I., Ricart, P., Richard, J. -C., Rivet, N., Riviere, J. G., Blanch, G. R., Rodrigo, C., Rodriguez-Palmero, A., Romero, C. S., Rothenbuhler, A., Rozenberg, F., del Prado, M. Y. R., Riera, J. S., Sanchez, O., Sanchez-Ramon, S., Schluter, A., Schmidt, M., Schweitzer, C. E., Scolari, F., Sediva, A., Seijo, L. M., Sene, D., Senoglu, S., Seppanen, M. R. J., Ilovich, A. S., Shahrooei, M., Smadja, D., Sobh, A., Moreno, X. S., Sole-Violan, J., Soler, C., Soler-Palacin, P., Stepanovskiy, Y., Stoclin, A., Taccone, F., Tandjaoui-Lambiottea, Y., Taupin, J. -L., Tavernier, S. J., Thumerelle, C., Tomasoni, G., Toubiana, J., Alvarez, J. T., Trouillet-Assanta, S., Troya, J., Tucci, A., Uzunhan, Y., Vabres, P., Valencia-Ramos, J., van Den Rym, A. M., Vandernoot, I., Vatansev, H., Velez-Santamaria, V., Viel, S., Vilain, C., Vilaire, M. E., Vincent, A., Voiriot, G., Vuotto, F., Yosunkaya, A., Young, B. E., Yucel, F., Zannad, F., Zatz, M., Belota, A., Foti, G., Bellani, G., Citerio, G., Contro, E., Pesci, A., Valsecchi, M. 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Cloherty, A, Elbers, P, Fleuren, L, Geerlings, S, Geerts, B, Geijtenbeek, T, Girbes, A, Goorhuis, B, Grobusch, M, Hafkamp, F, Hagens, L, Hamann, J, Harris, V, Hemke, R, Hermans, S, Heunks, L, Hollmann, M, Horn, J, Hovius, J, de Jong, M, Koning, R, van Mourik, N, Nellen, J, Paulus, F, Peters, E, van der Poll, T, Preckel, B, Prins, J, Raasveld, J, Reijnders, T, Schinkel, M, Schultz, M, Schuurman, A, Sigaloff, K, Smit, M, Stijnis, C, Stilma, W, Teunissen, C, Thoral, P, Tsonas, A, van der Valk, M, Veelo, D, Vlaar, A, de Vries, H, van Vugt, M, Joost Wiersinga, W, Wouters, D, Zwinderman, A, Abelb, L, Iuti, F, Muhsen, S, Al-Mulla, F, Anderson, M, Bogunovic, D, Bondarenko, A, Bryceson, Y, Bustamante, C, Butte, M, Chakravorty, S, Christodoulou, J, Cirulli, E, Condino-Neto, A, Cooper, M, Derisi, J, Desai, M, Drolet, B, Espinosa, S, Franco, J, Gregersen, P, Hagin, D, Heath, J, Henrickson, S, Hsieh, E, Imai, K, Itan, Y, Karamitros, T, Kisanda, K, Ku, C, Ling, Y, Lucas, C, Maniatis, T, Marodi, L, Milner, J, Mironska, K, Morio, T, Notarangeloa, L, Novelli, G, Novelli, A, O'Farrelly, C, Okada, S, Planas, A, Prando, C, Pujol, A, Renia, L, Renieri, A, Sancho-Shimizu, V, Sankaran, V, Barrett, K, Turvey, S, Uddin, F, Uddin, M, Vazquez, S, von Bernuth, H, Washington, N, Zawadzki, P, Sua, H, Casanovaa, J, Human genetics of infectious diseases : Mendelian predisposition (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Rockefeller University [New York], National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Tartu, Hospices Civils de Lyon (HCL), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de référence des rhumatismes inflammatoires et maladies auto-immunes systémiques rares de l’enfant / National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children [Lyon] (RAISE), Lyon Immunopathology Federation (LIFe), Tartu University Hospital [Tartu, Estonia], Hôpital Foch [Suresnes], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires (H&P), UFR SMBH-Université Sorbonne Paris Nord, Helix [San Mateo, CA], University Medical Center [Utrecht], IRCCS Ospedale San Raffaele [Milan, Italy], Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Yale University School of Medicine, Innovations thérapeutiques en hémostase (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Immunogenetics of pediatric autoimmune diseases (Equipe Inserm U1163), Centre National de Référence Maladies auto-immunes Systémiques Rares [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université de Paris (UP), Immunologie Translationnelle - Translational Immunology lab, Institut Pasteur [Paris], Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Chaire Génomique humaine et évolution, Collège de France (CdF (institution)), Amsterdam Neuroscience [Pays-Bas], Vrije Universiteit Amsterdam [Amsterdam] (VU)-University of Amsterdam [Amsterdam] (UvA)-VU University Medical Center [Amsterdam], McGill University Health Center [Montreal] (MUHC), Garvan Institute of Medical Research [Darlinghurst, Australia], University of New South Wales [Sydney] (UNSW), Ghent University Hospital, Hospital Universitario Mutua de Terrassa, Universitat de Barcelona (UB), Institut d’Investigació Germans Trias i Pujol = Germans Trias i Pujol Research Institute (IGTP), Universitat de Vic-Universitat Central de Catalunya, España, Institució Catalana de Recerca i Estudis Avançats (ICREA), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Howard Hughes Medical Institute [New York] (HHMI), Howard Hughes Medical Institute (HHMI)-New York University School of Medicine, NYU System (NYU)-NYU System (NYU)-Rockefeller University [New York]-Columbia University Irving Medical Center (CUIMC), Hospital Universitario de Gran Canaria Dr Negrin, University Fernando Pessoa - UFP, Centre National de Recherche en Génomique Humaine (CNRGH), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Aarhus University Hospital, Aarhus University [Aarhus], Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Fondazione MBBM-Ospedale [Monza, Italie], San Gerardo Hospital, Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Anesthésie réanimation [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), University of Bergen (UiB), Haukeland University Hospital, Consiglio Nazionale delle Ricerche [Napoli] (CNR), Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia [Brescia], Università degli Studi di Brescia [Brescia], Università degli Studi di Pavia, Fondazione IRCCS Policlinico San Matteo, CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université de Paris - UFR Médecine Paris Nord [Santé] (UP Médecine Paris Nord), Service d'Immunologie [CHU Pitié-Salpétrière], Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), UM1 HG006504/HG/NHGRI NIH HHS/United States, P01 AI138938/AI/NIAID NIH HHS/United States, U19 AI111825/AI/NIAID NIH HHS/United States, U24 HG008956/HG/NHGRI NIH HHS/United States, MR/S032304/1/MRC_/Medical Research Council/United Kingdom, UKRI Future Leader's Fellowship, The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, The Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, the Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the French National Research Agency (ANR) under the Investments for the Future program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project (ANRS-COV05), the Square Foundation, Grandir – Fonds de solidarité pour l’enfance, the SCOR Corporate Foundation for Science, the Institut Institut National de la Santé et de la Recherche Médicale (INSERM), and the University of Paris. Samples from San Raffaele Hospital were obtained through the Covid-BioB project and by healthcare personnel of San Raffaele Hospital, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) clinical laboratory and clinical research unit, funded by the Program Project COVID-19 OSR-UniSR and Fondazione Telethon. The French COVID Cohort Study Group was sponsored by INSERM and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). The Cov-Contact Cohort was supported by the REACTing consortium, the French Ministry of Health, and the European Commission (RECOVER WP 6). The Milieu Intérieur Consortium was supported by the French Government’s Investissement d’Avenir program, Laboratoire d’Excellence Milieu Intérieur grant (ANR-10-LABX-69-01) (primary investigators: L.Q.-M. and D.Du.). The Simoa experiment was supported by the PHRC-20-0375 COVID-19 grant 'DIGITAL COVID' (primary investigator: G.G.). S.G.T. is supported by a Leadership 3 Investigator Grant awarded by the National Health and Medical Research Council of Australia and a COVID19 Rapid Response Grant awarded by UNSW Sydney. C.R.-G. and colleagues were supported by the Instituto de Salud Carlos III (COV20_01333 and COV20_01334, Spanish Ministry of Science and Innovation RTC-2017-6471-1, AEI/FEDER, UE) and Cabildo Insular de Tenerife (CGIEU0000219140 and 'Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19'). S.T.-A. and A.B. were supported by ANR-20-COVI-0064 (primary investigator: A.Be.). This work is supported by the French Ministry of Health 'Programme Hospitalier de Recherche Clinique Inter regional 2013,' by the Contrat de Plan Etat-Lorraine and FEDER Lorraine, and by a public grant overseen by the French National Research Agency (ANR) as part of the second Investissements d’Avenir program FIGHT-HF (reference no. ANR-15-RHU-0004) and by the French PIA project 'Lorraine Université d’Excellence' (reference no. ANR-15-IDEX-04-LUE) (45), and biobanking is performed by the Biological Resource Center Lorrain BB-0033-00035. This study was supported by the Fonds IMMUNOV, for Innovation in Immunopathology, by a grant from the Agence National de la Recherche (ANR-flash Covid19 'AIROCovid' to F.R.-L.), and by the FAST Foundation (French Friends of Sheba Tel Hashomer Hospital). Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1, a George Mason University Fast Grant, and the G. Harold and Leila Y. Mathers Charitable Foundation. The Amsterdam UMC Covid-19 Biobank was supported by grants from the Amsterdam Corona Research Fund, the Dr. C.J. Vaillant Fund, and the Netherlands Organization for Health Research and Development [ZonMw, NWO-Vici-Grant (grant no. 918·19·627 to D.v.d.B.)]. This work was also supported by the Division of Intramural Research of the National Institute of Dental Craniofacial Research and the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by Regione Lombardia, Italy (project 'Risposta immune in pazienti con COVID-19 e comorbidita'). The opinions and assertions expressed herein are those of the author(s) and do not necessarily reflect the official policy or position of the Uniformed Services University or the Department of Defense. J.H. holds an Institut Imagine M.D.-Ph.D. fellowship from the Fondation Bettencourt Schueller. J.R. is supported by the INSERM Ph.D. program ('poste d’accueil Inserm'). P.Ba. was supported by the French Foundation for Medical Research (FRM, EA20170638020) and the M.D.-Ph.D. program of the Imagine Institute (with the support of the Fondation Bettencourt-Schueller). We thank the Association 'Turner et vous' for their help and support. Sample processing at IrsiCaixa was possible thanks to the crowdfunding initiative YoMeCorono. D.C.V. is supported by the Fonds de la recherche en santé du Québec clinician-scientist scholar program. K.K. was supported by the Estonian Research Council grant PUT1367. We thank the GEN-COVID Multicenter Study (https://sites.google.com/dbm.unisi.it/gen-covid). We thank the NIAID Office of Cyber Infrastructure and Computational Biology, Bioinformatics and Computational Biosciences Branch (contract no. HHSN316201300006W/HHSN27200002 to MSC, Inc.), the Operations Engineering Branch for developing the HGRepo system to enable streamlined access to the data, and the NCI Advanced Biomedical Computational Science (ABCS) for data transformation support. Biomedical Advanced Research and Development Authority was supported under contract no. HHSO10201600031C (to J.H.). Financial support was provided by the National Institute of Allergy and Infectious Diseases (NIAID) K08AI135091, the Burroughs Wellcome Fund CAMS, the Clinical Immunology Society, and the American Academy of Allergy, Asthma, and Immunology, We thank the patients, their families, and healthy donors for placing their trust in us. We thank the French Incontinentia pigmenti association for their help and support. We thank Y. Nemirovskaya, D. Papandrea, M. Woollett, D. Liu, C. Rivalain, and C. Patissier for administrative assistance, D. Kapogiannis (National Institute on Aging) for providing healthy donor samples, and S. Xirasager, J. Barnett, X. Cheng, S. Weber, J. Danielson, B. Garabedian, and H. Matthews for their assistance in this study. We also thank R. Apps, B. Ryan, and Y. Belkaid of the CHI for their assistance. We thank the CRB-Institut Jérôme Lejeune, CRB-BioJeL, Paris, France, for their assistance. We thank M. C. García Guerrero, I. Erkizia, E. Grau, M. Massanella from IrsiCaixa AIDS Research Institute, Badalona, Spain, and J. Guitart from the Department of Clinical Genetics, University Hospital Germans Trias i Pujol, Badalona, Spain, for providing samples. We also thank J. Dalmau from IrsiCaixa for assistance, HGID Lab, NIAID-USUHS Immune Response to COVID Group, COVID Clinicians, COVID-STORM Clinicians, Imagine COVID Group, French COVID Cohort Study Group, The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank, COVID Human Genetic, CoV-Contact Cohort: Loubna Alavoine, Karine K. A. Amat, Sylvie Behillil, Julia Bielicki, Patricia Bruijning, Charles Burdet, Eric Caumes, Charlotte Charpentier, Bruno Coignard, Yolande Costa, Sandrine Couffin-Cadiergues, Florence Damond, Aline Dechanet, Christelle Delmas, Diane Descamps, Xavier Duval, Jean-Luc Ecobichon, Vincent Enouf, Hélène Espérou, Wahiba Frezouls, Nadhira Houhou, Emila Ilic-Habensus, Ouifiya Kafif, John Kikoine, Quentin Le Hingrat, David Lebeaux, Anne Leclercq, Jonathan Lehacaut, Sophie Letrou, Bruno Lina, Jean-Christophe Lucet, Denis Malvy, Pauline Manchon, Milica Mandic, Mohamed Meghadecha, Justina Motiejunaite, Mariama Nouroudine, Valentine Piquard, Andreea Postolache, Caroline Quintin, Jade Rexach, Layidé Roufai, Zaven Terzian, Michael Thy, Sarah Tubiana, Sylvie van der Werf, Valérie Vignali, Benoit Visseaux, Yazdan Yazdanpanah, COVID Human Genetic Effort: Laurent Abel, Alessandro Aiuti, Saleh Al Muhsen, Fahd Al-Mulla, Mark S. Anderson, Andrés Augusto Arias, Hagit Baris Feldman, Dusan Bogunovic, Alexandre Bolze, Anastasiia Bondarenko, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Carlos D. Bustamante, Manish Butte, Giorgio Casari, Samya Chakravorty, John Christodoulou, Elizabeth Cirulli, Antonio Condino-Neto, Megan A. Cooper, Clifton L. Dalgard, Joseph L. DeRisi, Murkesh Desai, Beth A. Drolet, Sara Espinosa, Jacques Fellay, Carlos Flores, Jose Luis Franco, Peter K. Gregersen, Filomeen Haerynck, David Hagin, Rabih Halwani, Jim Heath, Sarah E. Henrickson, Elena Hsieh, Kohsuke Imai, Yuval Itan, Timokratis Karamitros, Kai Kisand, Cheng-Lung Ku, Yu-Lung Lau, Yun Ling, Carrie L. Lucas, Tom Maniatis, Davoud Mansouri, Laszlo Marodi, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Trine Mogensen, Tomohiro Morio, Lisa F. P. Ng, Luigi D. Notarangelo, Giuseppe Novelli, Antonio Novelli, Cliona O'Farrelly, Satoshi Okada, Tayfun Ozcelik, Rebeca Perez de Diego, Anna M. Planas, Carolina Prando, Aurora Pujol, Lluis Quintana-Murci, Laurent Renia, Alessandra Renieri, Carlos Rodríguez-Gallego, Vanessa Sancho-Shimizu, Vijay Sankaran, Kelly Schiabor Barrett, Mohammed Shahrooei, Andrew Snow, Pere Soler-Palacín, András N. Spaan, Stuart Tangye, Stuart Turvey, Furkan Uddin, Mohammed J. Uddin, Diederik van de Beek, Sara E. Vazquez, Donald C. Vinh, Horst von Bernuth, Nicole Washington, Pawel Zawadzki, Helen C. Su, Jean-Laurent Casanova, Amsterdam UMC Covid-19 Biobank: Michiel van Agtmael, Anna Geke Algera, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije Bomers, Lieuwe Bos, Michela Botta, Justin de Brabander, Godelieve Bree, Matthijs C. Brouwer, Sanne de Bruin, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Paul Elbers, Lucas Fleuren, Suzanne Geerlings, Bart Geerts, Theo Geijtenbeek, Armand Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura Hagens, Jorg Hamann, Vanessa Harris, Robert Hemke, Sabine M. Hermans, Leo Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Niels van Mourik, Jeaninne Nellen, Frederique Paulus, Edgar Peters, Tom van der Poll, Benedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom Reijnders, Michiel Schinkel, Marcus J. Schultz, Alex Schuurman, Kim Sigaloff, Marry Smit, Cornelis S. Stijnis, Willemke Stilma, Charlotte Teunissen, Patrick Thoral, Anissa Tsonas, Marc van der Valk, Denise Veelo, Alexander P. J. Vlaar, Heder de Vries, Michèle van Vugt, W. Joost Wiersinga, Dorien Wouters, A. H. (Koos) Zwinderman, Diederik van de Beek, HGID Lab: Andrés Augusto Arias, Bertrand Boisson, Soraya Boucherit, Jacinta Bustamante, Marwa Chbihi, Jie Chen, Maya Chrabieh, Tatiana Kochetkov, Tom Le Voyer, Dana Liu, Yelena Nemirovskaya, Masato Ogishi, Dominick Papandrea, Cécile Patissier, Franck Rapaport, Manon Roynard, Natasha Vladikine, Mark Woollett, Peng Zhang, NIAID-USUHS Immune Response to COVID Group: Anuj Kashyap, Li Ding, Marita Bosticardo, Qinlu Wang, Sebastian Ochoa, Hui Liu, Samuel D. Chauvin, Michael Stack, Galina Koroleva, Neha Bansal, Clifton L. Dalgard, Andrew L. Snow, COVID Clinicians: Jorge Abad, Sergio Aguilera-Albesa, Ozge Metin Akcan, Ilad Alavi Darazam, Juan C. Aldave, Miquel Alfonso Ramos, Seyed Alireza Nadji, Gulsum Alkan, Jerome Allardet-Servent, Luis M. Allende, Laia Alsina, Marie-Alexandra Alyanakian, Blanca Amador-Borrero, Zahir Amoura, Arnau Antolí, Sevket Arslan, Sophie Assant, Terese Auguet, Axelle Azot, Fanny Bajolle, Aurélie Baldolli, Maite Ballester, Hagit Baris Feldman, Benoit Barrou, Alexandra Beurton, Agurtzane Bilbao, Geraldine Blanchard-Rohner, Ignacio Blanco, Adeline Blandinières, Daniel Blazquez-Gamero, Marketa Bloomfield, Mireia Bolivar-Prados, Raphael Borie, Ahmed A. Bousfiha, Claire Bouvattier, Oksana Boyarchuk, Maria Rita P. Bueno, Jacinta Bustamante, Juan José Cáceres Agra, Semra Calimli, Ruggero Capra, Maria Carrabba, Carlos Casasnovas, Marion Caseris, Martin Castelle, Francesco Castelli, Martín Castillo de Vera, Mateus V. Castro, Emilie Catherinot, Martin Chalumeau, Bruno Charbit, Matthew P. Cheng, Père Clavé, Bonaventura Clotet, Anna Codina, Fatih Colkesen, Fatma Colkesen, Roger Colobran, Cloé Comarmond, Angelo G. Corsico, David Dalmau, David Ross Darley, Nicolas Dauby, Stéphane Dauger, Loic de Pontual, Amin Dehban, Geoffroy Delplancq, Alexandre Demoule, Antonio Di Sabatino, Jean-Luc Diehl, Stephanie Dobbelaere, Sophie Durand, Waleed Eldars, Mohamed Elgamal, Marwa H. Elnagdy, Melike Emiroglu, Emine Hafize Erdeniz, Selma Erol Aytekin, Romain Euvrard, Recep Evcen, Giovanna Fabio, Laurence Faivre, Antonin Falck, Muriel Fartoukh, Morgane Faure, Miguel Fernandez Arquero, Carlos Flores, Bruno Francois, Victoria Fumadó, Francesca Fusco, Blanca Garcia Solis, Pascale Gaussem, Juana Gil-Herrera, Laurent Gilardin, Monica Girona Alarcon, Mónica Girona-Alarcón, Jean-Christophe Goffard, Funda Gok, Rafaela González-Montelongo, Antoine Guerder, Yahya Gul, Sukru Nail Guner, Marta Gut, Jérôme Hadjadj, Filomeen Haerynck, Rabih Halwani, Lennart Hammarström, Nevin Hatipoglu, Elisa Hernandez-Brito, María Soledad Holanda-Peña, Juan Pablo Horcajada, Sami Hraiech, Linda Humbert, Alejandro D. Iglesias, Antonio Íñigo-Campos, Matthieu Jamme, María Jesús Arranz, Iolanda Jordan, Fikret Kanat, Hasan Kapakli, Iskender Kara, Adem Karbuz, Kadriye Kart Yasar, Sevgi Keles, Yasemin Kendir Demirkol, Adam Klocperk, Zbigniew J. Król, Paul Kuentz, Yat Wah M. Kwan, Jean-Christophe Lagier, Yu-Lung Lau, Fleur Le Bourgeois, Yee-Sin Leo, Rafael Leon Lopez, Daniel Leung, Michael Levin, Michael Levy, Romain Lévy, Zhi Li, Agnes Linglart, José M. Lorenzo-Salazar, Céline Louapre, Catherine Lubetzki, Charles-Edouard Luyt, David C. Lye, Davood Mansouri, Majid Marjani, Jesus Marquez Pereira, Andrea Martin, David Martínez Pueyo, Javier Martinez-Picado, Iciar Marzana, Alexis Mathian, Larissa R. B. Matos, Gail V. Matthews, Julien Mayaux, Jean-Louis Mège, Isabelle Melki, Jean-François Meritet, Ozge Metin, Isabelle Meyts, Mehdi Mezidi, Isabelle Migeotte, Maude Millereux, Tristan Mirault, Clotilde Mircher, Mehdi Mirsaeidi, Abián Montesdeoca Melián, Antonio Morales Martinez, Pierre Morange, Clémence Mordacq, Guillaume Morelle, Stéphane Mouly, Adrián Muñoz-Barrera, Cyril Nafati, João Farela Neves, Lisa F. P. Ng Yeray Novoa Medina, Esmeralda Nuñez Cuadros, J. Gonzalo Ocejo-Vinyals, Zerrin Orbak, Mehdi Oualha, Tayfun Özçelik, Qiang Pan Hammarström, Christophe Parizot, Tiffany Pascreau, Estela Paz-Artal, Rebeca Pérez de Diego, Aurélien Philippe, Quentin Philippot, Laura Planas-Serra, Dominique Ploin, Julien Poissy, Géraldine Poncelet, Marie Pouletty, Paul Quentric, Didier Raoult, Anne-Sophie Rebillat, Ismail Reisli, Pilar Ricart, Jean-Christophe Richard, Nadia Rivet, Jacques G. Rivière, Gemma Rocamora Blanch, Carlos Rodrigo, Carlos Rodriguez-Gallego, Agustí Rodríguez-Palmero, Carolina Soledad Romero, Anya Rothenbuhler, Flore Rozenberg, Maria Yolanda Ruiz del Prado, Joan Sabater Riera, Oliver Sanchez, Silvia Sánchez-Ramón, Agatha Schluter, Matthieu Schmidt, Cyril E. Schweitzer, Francesco Scolari, Anna Sediva, Luis M. Seijo, Damien Sene, Sevtap Senoglu, Mikko R. J. Seppänen, Alex Serra Ilovich, Mohammad Shahrooei, David Smadja, Ali Sobh, Xavier Solanich Moreno, Jordi Solé-Violán, Catherine Soler, Pere Soler-Palacín, Yuri Stepanovskiy, Annabelle Stoclin, Fabio Taccone, Yacine Tandjaoui-Lambiotte, Jean-Luc Taupin, Simon J. Tavernier, Benjamin Terrier, Caroline Thumerelle, Gabriele Tomasoni, Julie Toubiana, Josep Trenado Alvarez, Sophie Trouillet-Assant, Jesús Troya, Alessandra Tucci, Matilde Valeria Ursini, Yurdagul Uzunhan, Pierre Vabres, Juan Valencia-Ramos, Ana Maria Van Den Rym, Isabelle Vandernoot, Hulya Vatansev, Valentina Vélez-Santamaria, Sébastien Viel, Cédric Vilain, Marie E. Vilaire, Audrey Vincent, Guillaume Voiriot, Fanny Vuotto, Alper Yosunkaya, Barnaby E. Young, Fatih Yucel, Faiez Zannad, Mayana Zatz, Alexandre Belot, COVID-STORM Clinicians: Giuseppe Foti, Giacomo Bellani, Giuseppe Citerio, Ernesto Contro, Alberto Pesci, Maria Grazia Valsecchi, Marina Cazzaniga, Imagine COVID Group: Christine Bole-Feysot, Stanislas Lyonnet, Cécile Masson, Patrick Nitschke, Aurore Pouliet, Yoann Schmitt, Frederic Tores, Mohammed Zarhrate, French COVID Cohort Study Group: Laurent Abel, Claire Andrejak, François Angoulvant, Delphine Bachelet, Romain Basmaci, Sylvie Behillil, Marine Beluze, Dehbia Benkerrou, Krishna Bhavsar, François Bompart, Lila Bouadma, Maude Bouscambert, Mireille Caralp, Minerva Cervantes-Gonzalez, Anissa Chair, Alexandra Coelho, Camille Couffignal, Sandrine Couffin-Cadiergues, Eric D’ortenzio, Charlene Da Silveira, Marie-Pierre Debray, Dominique Deplanque, Diane Descamps, Mathilde Desvallées, Alpha Diallo, Alphonsine Diouf, Céline Dorival, François Dubos, Xavier Duval, Philippine Eloy, Vincent V. E. Enouf, Hélène Esperou, Marina Esposito-Farese, Manuel Etienne, Nadia Ettalhaoui, Nathalie Gault, Alexandre Gaymard, Jade Ghosn, Tristan Gigante, Isabelle Gorenne, Jérémie Guedj, Alexandre Hoctin, Isabelle Hoffmann, Salma Jaafoura, Ouifiya Kafif, Florentia Kaguelidou, Sabina Kali, Antoine Khalil, Coralie Khan, Cédric Laouénan, Samira Laribi, Minh Le, Quentin Le Hingrat, Soizic Le Mestre, Hervé Le Nagard, François-Xavier Lescure, Yves Lévy, Claire Levy-Marchal, Bruno Lina, Guillaume Lingas, Jean Christophe Lucet, Denis Malvy, Marina Mambert, France Mentré, Noémie Mercier, Amina Meziane, Hugo Mouquet, Jimmy Mullaert, Nadège Neant, Marion Noret, Justine Pages, Aurélie Papadopoulos, Christelle Paul, Nathan Peiffer-Smadj, Ventzislava Petrov-Sanchez, Gilles Peytavin, Olivier Picone, Oriane Puéchal, Manuel Rosa-Calatrava, Bénédicte Rossignol, Patrick Rossignol, Carine Roy, Marion Schneider, Caroline Semaille, Nassima Si Mohammed, Lysa Tagherset, Coralie Tardivon, Marie-Capucine Tellier, François Téoulé, Olivier Terrier, Jean-François Timsit, Théo Treoux, Christelle Tual, Sarah Tubiana, Sylvie van der Werf, Noémie Vanel, Aurélie Veislinger, Benoit Visseaux, Aurélie Wiedemann, Yazdan Yazdanpanan, The Milieu Intérieur Consortium: Laurent Abel, Andres Alcover, Hugues Aschard, Kalla Astrom, Philippe Bousso, Pierre Bruhns, Ana Cumano, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Serge Hercberg, Olivier Lantz, Hugo Mouquet, Etienne Patin, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Matthew L. Albert, Darragh Duffy, Lluis Quintana-Murci, ANR-10-IAHU-0001,Imagine,Institut Hospitalo-Universitaire Imagine(2010), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-20-COVI-0003,GENCOVID,Identification des défauts monogéniques de l'immunité responsables des formes sévères de COVID-19 chez les patients précédemment en bonne santé(2020), ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), ANR-20-COVI-0064,IFN-COVID19,Etude de la régulation de la réponse interferon de type I dans le control de l'infection par SARS-Cov2 et sa pathogènese(2020), ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), ANR-15-IDEX-0004,LUE,Isite LUE(2015), ANR-20-COVI-0022,AIROCovid19,Analyse Omics de la réponse immune aigue au cours de l'infection à Covid19: rationnel moléculaire pour un traitement ciblé(2020), Howard Hughes Medical Institute, Rockefeller University, National Institutes of Health (US), National Center for Advancing Translational Sciences (US), George Mason University, National Human Genome Research Institute (US), Agence Nationale de la Recherche (France), Fondation pour la Recherche Médicale, Pershing Square Foundation, Institut National de la Santé et de la Recherche Médicale (France), Université de Paris, Fondazione Telethon, Ministère des Solidarités et de la Santé (France), European Commission, National Health and Medical Research Council (Australia), University of New South Wales (Australia), Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Cabildo de Tenerife, Fondation Bettencourt Schueller, Estonian Research Council, Rosen, Lindsey B., Michailidis, Eleftherios, Haljasmägi, Liis, Spaan, András N., Quintana-Murci, Lluis, Beek, Diederik van der, Vinh, Donald C., Tangye, Stuart G., Martínez-Picado, Javier, Brodin, Peter, Nussenzweig, Michel C., Rodríguez-Gallego, Carlos, Mogensen, Trine, Oler, Andrew J., Burbelo, Peter D., Husebye, Eystein S., Children's Hospital, HUS Children and Adolescents, Clinicum, Department of Medicine, Neurology, AII - Infectious diseases, ANS - Neuroinfection & -inflammation, Infectious diseases, ACS - Pulmonary hypertension & thrombosis, Intensive Care Medicine, ACS - Microcirculation, ACS - Heart failure & arrhythmias, Anesthesiology, ACS - Diabetes & metabolism, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Yale School of Medicine [New Haven, Connecticut] (YSM), Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis (IThEM - U1140), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Paris Cité (UPCité), Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Collège de France - Chaire Génomique humaine et évolution, Garvan Institute of medical research, Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), San Gerardo Hospital of Monza, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Università degli Studi di Brescia = University of Brescia (UniBs), Università degli Studi di Pavia = University of Pavia (UNIPV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, UFR Médecine [Santé] - Université Paris Cité (UFR Médecine UPCité), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Modeling & analysis for medical imaging and Diagnosis (MYRIAD), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Virologie (CNRS-UMR3569), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and J. Guitart from the Department of Clinical Genetics, University Hospital Germans Trias i Pujol, Badalona, Spain, for providing samples. We also thank J. Dalmau from IrsiCaixa for assistance HGID Lab, NIAID-USUHS Immune Response to COVID Group, COVID Clinicians, COVID-STORM Clinicians, Imagine COVID Group, French COVID Cohort Study Group, The Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank, COVID Human Genetic CoV-Contact Cohort: Loubna Alavoine, Karine K. A. Amat, Sylvie Behillil, Julia Bielicki, Patricia Bruijning, Charles Burdet, Eric Caumes, Charlotte Charpentier, Bruno Coignard, Yolande Costa, Sandrine Couffin-Cadiergues, Florence Damond, Aline Dechanet, Christelle Delmas, Diane Descamps, Xavier Duval, Jean-Luc Ecobichon, Vincent Enouf, Hélène Espérou, Wahiba Frezouls, Nadhira Houhou, Emila Ilic-Habensus, Ouifiya Kafif, John Kikoine, Quentin Le Hingrat, David Lebeaux, Anne Leclercq, Jonathan Lehacaut, Sophie Letrou, Bruno Lina, Jean-Christophe Lucet, Denis Malvy, Pauline Manchon, Milica Mandic, Mohamed Meghadecha, Justina Motiejunaite, Mariama Nouroudine, Valentine Piquard, Andreea Postolache, Caroline Quintin, Jade Rexach, Layidé Roufai, Zaven Terzian, Michael Thy, Sarah Tubiana, Sylvie van der Werf, Valérie Vignali, Benoit Visseaux, Yazdan Yazdanpanah COVID Human Genetic Effort: Laurent Abel, Alessandro Aiuti, Saleh Al Muhsen, Fahd Al-Mulla, Mark S. Anderson, Andrés Augusto Arias, Hagit Baris Feldman, Dusan Bogunovic, Alexandre Bolze, Anastasiia Bondarenko, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Carlos D. Bustamante, Manish Butte, Giorgio Casari, Samya Chakravorty, John Christodoulou, Elizabeth Cirulli, Antonio Condino-Neto, Megan A. Cooper, Clifton L. Dalgard, Joseph L. DeRisi, Murkesh Desai, Beth A. Drolet, Sara Espinosa, Jacques Fellay, Carlos Flores, Jose Luis Franco, Peter K. Gregersen, Filomeen Haerynck, David Hagin, Rabih Halwani, Jim Heath, Sarah E. Henrickson, Elena Hsieh, Kohsuke Imai, Yuval Itan, Timokratis Karamitros, Kai Kisand, Cheng-Lung Ku, Yu-Lung Lau, Yun Ling, Carrie L. Lucas, Tom Maniatis, Davoud Mansouri, Laszlo Marodi, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Trine Mogensen, Tomohiro Morio, Lisa F. P. Ng, Luigi D. Notarangelo, Giuseppe Novelli, Antonio Novelli, Cliona O'Farrelly, Satoshi Okada, Tayfun Ozcelik, Rebeca Perez de Diego, Anna M. Planas, Carolina Prando, Aurora Pujol, Lluis Quintana-Murci, Laurent Renia, Alessandra Renieri, Carlos Rodríguez-Gallego, Vanessa Sancho-Shimizu, Vijay Sankaran, Kelly Schiabor Barrett, Mohammed Shahrooei, Andrew Snow, Pere Soler-Palacín, András N. Spaan, Stuart Tangye, Stuart Turvey, Furkan Uddin, Mohammed J. Uddin, Diederik van de Beek, Sara E. Vazquez, Donald C. Vinh, Horst von Bernuth, Nicole Washington, Pawel Zawadzki, Helen C. Su, Jean-Laurent Casanova Amsterdam UMC Covid-19 Biobank: Michiel van Agtmael, Anna Geke Algera, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije Bomers, Lieuwe Bos, Michela Botta, Justin de Brabander, Godelieve Bree, Matthijs C. Brouwer, Sanne de Bruin, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Paul Elbers, Lucas Fleuren, Suzanne Geerlings, Bart Geerts, Theo Geijtenbeek, Armand Girbes, Bram Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura Hagens, Jorg Hamann, Vanessa Harris, Robert Hemke, Sabine M. Hermans, Leo Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Niels van Mourik, Jeaninne Nellen, Frederique Paulus, Edgar Peters, Tom van der Poll, Benedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom Reijnders, Michiel Schinkel, Marcus J. Schultz, Alex Schuurman, Kim Sigaloff, Marry Smit, Cornelis S. Stijnis, Willemke Stilma, Charlotte Teunissen, Patrick Thoral, Anissa Tsonas, Marc van der Valk, Denise Veelo, Alexander P. J. Vlaar, Heder de Vries, Michèle van Vugt, W. Joost Wiersinga, Dorien Wouters, A. H. (Koos) Zwinderman, Diederik van de Beek HGID Lab: Andrés Augusto Arias, Bertrand Boisson, Soraya Boucherit, Jacinta Bustamante, Marwa Chbihi, Jie Chen, Maya Chrabieh, Tatiana Kochetkov, Tom Le Voyer, Dana Liu, Yelena Nemirovskaya, Masato Ogishi, Dominick Papandrea, Cécile Patissier, Franck Rapaport, Manon Roynard, Natasha Vladikine, Mark Woollett, Peng Zhang NIAID-USUHS Immune Response to COVID Group: Anuj Kashyap, Li Ding, Marita Bosticardo, Qinlu Wang, Sebastian Ochoa, Hui Liu, Samuel D. Chauvin, Michael Stack, Galina Koroleva, Neha Bansal, Clifton L. Dalgard, Andrew L. Snow COVID Clinicians: Jorge Abad, Sergio Aguilera-Albesa, Ozge Metin Akcan, Ilad Alavi Darazam, Juan C. Aldave, Miquel Alfonso Ramos, Seyed Alireza Nadji, Gulsum Alkan, Jerome Allardet-Servent, Luis M. Allende, Laia Alsina, Marie-Alexandra Alyanakian, Blanca Amador-Borrero, Zahir Amoura, Arnau Antolí, Sevket Arslan, Sophie Assant, Terese Auguet, Axelle Azot, Fanny Bajolle, Aurélie Baldolli, Maite Ballester, Hagit Baris Feldman, Benoit Barrou, Alexandra Beurton, Agurtzane Bilbao, Geraldine Blanchard-Rohner, Ignacio Blanco, Adeline Blandinières, Daniel Blazquez-Gamero, Marketa Bloomfield, Mireia Bolivar-Prados, Raphael Borie, Ahmed A. Bousfiha, Claire Bouvattier, Oksana Boyarchuk, Maria Rita P. Bueno, Jacinta Bustamante, Juan José Cáceres Agra, Semra Calimli, Ruggero Capra, Maria Carrabba, Carlos Casasnovas, Marion Caseris, Martin Castelle, Francesco Castelli, Martín Castillo de Vera, Mateus V. Castro, Emilie Catherinot, Martin Chalumeau, Bruno Charbit, Matthew P. Cheng, Père Clavé, Bonaventura Clotet, Anna Codina, Fatih Colkesen, Fatma Colkesen, Roger Colobran, Cloé Comarmond, Angelo G. Corsico, David Dalmau, David Ross Darley, Nicolas Dauby, Stéphane Dauger, Loic de Pontual, Amin Dehban, Geoffroy Delplancq, Alexandre Demoule, Antonio Di Sabatino, Jean-Luc Diehl, Stephanie Dobbelaere, Sophie Durand, Waleed Eldars, Mohamed Elgamal, Marwa H. Elnagdy, Melike Emiroglu, Emine Hafize Erdeniz, Selma Erol Aytekin, Romain Euvrard, Recep Evcen, Giovanna Fabio, Laurence Faivre, Antonin Falck, Muriel Fartoukh, Morgane Faure, Miguel Fernandez Arquero, Carlos Flores, Bruno Francois, Victoria Fumadó, Francesca Fusco, Blanca Garcia Solis, Pascale Gaussem, Juana Gil-Herrera, Laurent Gilardin, Monica Girona Alarcon, Mónica Girona-Alarcón, Jean-Christophe Goffard, Funda Gok, Rafaela González-Montelongo, Antoine Guerder, Yahya Gul, Sukru Nail Guner, Marta Gut, Jérôme Hadjadj, Filomeen Haerynck, Rabih Halwani, Lennart Hammarström, Nevin Hatipoglu, Elisa Hernandez-Brito, María Soledad Holanda-Peña, Juan Pablo Horcajada, Sami Hraiech, Linda Humbert, Alejandro D. Iglesias, Antonio Íñigo-Campos, Matthieu Jamme, María Jesús Arranz, Iolanda Jordan, Fikret Kanat, Hasan Kapakli, Iskender Kara, Adem Karbuz, Kadriye Kart Yasar, Sevgi Keles, Yasemin Kendir Demirkol, Adam Klocperk, Zbigniew J. Król, Paul Kuentz, Yat Wah M. Kwan, Jean-Christophe Lagier, Yu-Lung Lau, Fleur Le Bourgeois, Yee-Sin Leo, Rafael Leon Lopez, Daniel Leung, Michael Levin, Michael Levy, Romain Lévy, Zhi Li, Agnes Linglart, José M. Lorenzo-Salazar, Céline Louapre, Catherine Lubetzki, Charles-Edouard Luyt, David C. Lye, Davood Mansouri, Majid Marjani, Jesus Marquez Pereira, Andrea Martin, David Martínez Pueyo, Javier Martinez-Picado, Iciar Marzana, Alexis Mathian, Larissa R. B. Matos, Gail V. Matthews, Julien Mayaux, Jean-Louis Mège, Isabelle Melki, Jean-François Meritet, Ozge Metin, Isabelle Meyts, Mehdi Mezidi, Isabelle Migeotte, Maude Millereux, Tristan Mirault, Clotilde Mircher, Mehdi Mirsaeidi, Abián Montesdeoca Melián, Antonio Morales Martinez, Pierre Morange, Clémence Mordacq, Guillaume Morelle, Stéphane Mouly, Adrián Muñoz-Barrera, Cyril Nafati, João Farela Neves, Lisa F. P. Ng Yeray Novoa Medina, Esmeralda Nuñez Cuadros, J. Gonzalo Ocejo-Vinyals, Zerrin Orbak, Mehdi Oualha, Tayfun Özçelik, Qiang Pan Hammarström, Christophe Parizot, Tiffany Pascreau, Estela Paz-Artal, Rebeca Pérez de Diego, Aurélien Philippe, Quentin Philippot, Laura Planas-Serra, Dominique Ploin, Julien Poissy, Géraldine Poncelet, Marie Pouletty, Paul Quentric, Didier Raoult, Anne-Sophie Rebillat, Ismail Reisli, Pilar Ricart, Jean-Christophe Richard, Nadia Rivet, Jacques G. Rivière, Gemma Rocamora Blanch, Carlos Rodrigo, Carlos Rodriguez-Gallego, Agustí Rodríguez-Palmero, Carolina Soledad Romero, Anya Rothenbuhler, Flore Rozenberg, Maria Yolanda Ruiz del Prado, Joan Sabater Riera, Oliver Sanchez, Silvia Sánchez-Ramón, Agatha Schluter, Matthieu Schmidt, Cyril E. Schweitzer, Francesco Scolari, Anna Sediva, Luis M. Seijo, Damien Sene, Sevtap Senoglu, Mikko R. J. Seppänen, Alex Serra Ilovich, Mohammad Shahrooei, David Smadja, Ali Sobh, Xavier Solanich Moreno, Jordi Solé-Violán, Catherine Soler, Pere Soler-Palacín, Yuri Stepanovskiy, Annabelle Stoclin, Fabio Taccone, Yacine Tandjaoui-Lambiotte, Jean-Luc Taupin, Simon J. Tavernier, Benjamin Terrier, Caroline Thumerelle, Gabriele Tomasoni, Julie Toubiana, Josep Trenado Alvarez, Sophie Trouillet-Assant, Jesús Troya, Alessandra Tucci, Matilde Valeria Ursini, Yurdagul Uzunhan, Pierre Vabres, Juan Valencia-Ramos, Ana Maria Van Den Rym, Isabelle Vandernoot, Hulya Vatansev, Valentina Vélez-Santamaria, Sébastien Viel, Cédric Vilain, Marie E. Vilaire, Audrey Vincent, Guillaume Voiriot, Fanny Vuotto, Alper Yosunkaya, Barnaby E. Young, Fatih Yucel, Faiez Zannad, Mayana Zatz, Alexandre Belot COVID-STORM Clinicians: Giuseppe Foti, Giacomo Bellani, Giuseppe Citerio, Ernesto Contro, Alberto Pesci, Maria Grazia Valsecchi, Marina Cazzaniga Imagine COVID Group: Christine Bole-Feysot, Stanislas Lyonnet, Cécile Masson, Patrick Nitschke, Aurore Pouliet, Yoann Schmitt, Frederic Tores, Mohammed Zarhrate French COVID Cohort Study Group: Laurent Abel, Claire Andrejak, François Angoulvant, Delphine Bachelet, Romain Basmaci, Sylvie Behillil, Marine Beluze, Dehbia Benkerrou, Krishna Bhavsar, François Bompart, Lila Bouadma, Maude Bouscambert, Mireille Caralp, Minerva Cervantes-Gonzalez, Anissa Chair, Alexandra Coelho, Camille Couffignal, Sandrine Couffin-Cadiergues, Eric D’ortenzio, Charlene Da Silveira, Marie-Pierre Debray, Dominique Deplanque, Diane Descamps, Mathilde Desvallées, Alpha Diallo, Alphonsine Diouf, Céline Dorival, François Dubos, Xavier Duval, Philippine Eloy, Vincent V. E. Enouf, Hélène Esperou, Marina Esposito-Farese, Manuel Etienne, Nadia Ettalhaoui, Nathalie Gault, Alexandre Gaymard, Jade Ghosn, Tristan Gigante, Isabelle Gorenne, Jérémie Guedj, Alexandre Hoctin, Isabelle Hoffmann, Salma Jaafoura, Ouifiya Kafif, Florentia Kaguelidou, Sabina Kali, Antoine Khalil, Coralie Khan, Cédric Laouénan, Samira Laribi, Minh Le, Quentin Le Hingrat, Soizic Le Mestre, Hervé Le Nagard, François-Xavier Lescure, Yves Lévy, Claire Levy-Marchal, Bruno Lina, Guillaume Lingas, Jean Christophe Lucet, Denis Malvy, Marina Mambert, France Mentré, Noémie Mercier, Amina Meziane, Hugo Mouquet, Jimmy Mullaert, Nadège Neant, Marion Noret, Justine Pages, Aurélie Papadopoulos, Christelle Paul, Nathan Peiffer-Smadj, Ventzislava Petrov-Sanchez, Gilles Peytavin, Olivier Picone, Oriane Puéchal, Manuel Rosa-Calatrava, Bénédicte Rossignol, Patrick Rossignol, Carine Roy, Marion Schneider, Caroline Semaille, Nassima Si Mohammed, Lysa Tagherset, Coralie Tardivon, Marie-Capucine Tellier, François Téoulé, Olivier Terrier, Jean-François Timsit, Théo Treoux, Christelle Tual, Sarah Tubiana, Sylvie van der Werf, Noémie Vanel, Aurélie Veislinger, Benoit Visseaux, Aurélie Wiedemann, Yazdan Yazdanpanan The Milieu Intérieur Consortium: Laurent Abel, Andres Alcover, Hugues Aschard, Kalla Astrom, Philippe Bousso, Pierre Bruhns, Ana Cumano, Caroline Demangel, Ludovic Deriano, James Di Santo, Françoise Dromer, Gérard Eberl, Jost Enninga, Jacques Fellay, Ivo Gomperts-Boneca, Milena Hasan, Serge Hercberg, Olivier Lantz, Hugo Mouquet, Etienne Patin, Sandra Pellegrini, Stanislas Pol, Antonio Rausell, Lars Rogge, Anavaj Sakuntabhai, Olivier Schwartz, Benno Schwikowski, Spencer Shorte, Frédéric Tangy, Antoine Toubert, Mathilde Touvier, Marie-Noëlle Ungeheuer, Matthew L. Albert, Darragh Duffy, Lluis Quintana-Murci, Bastard, Paul [0000-0002-5926-8437], Rosen, Lindsey B. [0000-0001-5894-3878], Zhang, Qian [0000-0002-9040-3289], Michailidis, Eleftherios [0000-0002-9907-4346], Dorgham, Karim [0000-0001-9539-3203], Béziat, Vivien [0000-0002-4020-824X], Manry, Jérémy [0000-0001-5998-2051], Shaw, Elana [0000-0001-9265-8026], Haljasmägi, Liis [0000-0001-7162-9808], Peterson, Pärt [0000-0001-6755-791X], Lorenzo, Lazaro [0000-0001-6648-8684], Bizien, Lucy [0000-0001-9163-9122], Trouillet-Assant, Sophie [0000-0001-6439-4705], Dobbs, Kerry [0000-0002-3432-3137], Belot, Alexandre [0000-0003-4902-5332], Kallaste, Anne [0000-0002-7492-667X], Tandjaoui-Lambiotte, Yacine [0000-0003-1123-4788], Le Pen, Jeremie [0000-0001-7025-9526], Kerner, Gaspard [0000-0003-0146-9428], Bigio, Benedetta [0000-0001-7291-5638], Yang, Rui [0000-0003-4427-2158], Bolze, Alexandre [0000-0001-7399-2766], Spaan, András N. [0000-0001-5981-7259], Aiuti, Alessandro [0000-0002-5398-1717], Lampasona, Vito [0000-0001-5162-8445], Piemonti, Lorenzo [0000-0002-2172-2198], Bilguvar, Kaya [0000-0002-7313-7652], Migaud, Mélanie [0000-0003-3062-1214], Hadjadj, Jérome [0000-0002-2520-3272], Terrier, Benjamin [0000-0001-6612-7336], Duffy, Darragh [0000-0002-8875-2308], Quintana-Murci, Lluis [0000-0003-2429-6320], Beek, Diederik van der [0000-0002-4571-044X], Roussel, Lucie [0000-0001-5355-702X], Vinh, Donald C. [0000-0003-1347-7767], Tangye, Stuart G. [0000-0002-5360-5180], Dalmau, David [0000-0003-1936-478X], Martínez-Picado, Javier [0000-0002-4916-2129], Brodin, Peter [0000-0002-8103-0046], Nussenzweig, Michel C. [0000-0003-0592-8564], Boisson-Dupuis, Stéphanie [0000-0002-7115-116X], Rodríguez-Gallego, Carlos [0000-0002-4344-8644], Mogensen, Trine [0000-0002-1853-9704], Oler, Andrew J. [0000-0002-6310-0434], Burbelo, Peter D. [0000-0003-1717-048X], Cohen, Jeffrey [0000-0003-0238-7176], Bettini, Laura Rachele [0000-0002-0280-1704], Bonfanti, Paolo [0000-0001-7289-8823], Rieux-Laucat, Frédéric [0000-0001-7858-7866], Husebye, Eystein S. [0000-0002-7886-2976], Castagnoli, Riccardo [0000-0003-0029-9383], Licari, Amelia [0000-0002-1773-6482], Vougny, Marie-Christine, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Instituts Hospitalo-Universitaires - Institut Hospitalo-Universitaire Imagine - - Imagine2010 - ANR-10-IAHU-0001 - IAHU - VALID, Laboratoires d'excellence - GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE - - MILIEU INTERIEUR2010 - ANR-10-LABX-0069 - LABX - VALID, ISITE - Isite LUE - - LUE2015 - ANR-15-IDEX-0004 - IDEX - VALID, Combattre l'insuffisance cardiaque - - FIGHT-HF2015 - ANR-15-RHUS-0004 - RHUS - VALID, Etude de la régulation de la réponse interferon de type I dans le control de l'infection par SARS-Cov2 et sa pathogènese - - IFN-COVID192020 - ANR-20-COVI-0064 - COVID-19 - VALID, Analyse Omics de la réponse immune aigue au cours de l'infection à Covid19: rationnel moléculaire pour un traitement ciblé - - AIROCovid192020 - ANR-20-COVI-0022 - COVID-19 - VALID, Identification des défauts monogéniques de l'immunité responsables des formes sévères de COVID-19 chez les patients précédemment en bonne santé - - GENCOVID2020 - ANR-20-COVI-0003 - COVID-19 - VALID, Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière] (DMIIC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Université Paris Cité - UFR Médecine [Santé] (UPCité UFR Médecine), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Howard Hughes Medical Institute (HHMI)-Rockefeller University [New York]-Columbia University Irving Medical Center (CUIMC)-New York University School of Medicine, NYU System (NYU)-NYU System (NYU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'anesthésiologie et soins intensifs [CHU Pitié-Salpêtrière], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université, Paris Diderot - Paris 7 - UFR Lettres, Arts, Langues, Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Service d'immunologie [CHU Pitié-Salpétrière], Funding: The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the French National Research Agency (ANR) under the 'Investments for the Future' program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project, ANRS-COV05, the Square Foundation, Grandir - Fonds de solidarité pour l’enfance, the SCOR Corporate Foundation for Science, Institut Institut National de la Santé et de la Recherche Médicale (INSERM) and the University of Paris. Samples from San Raffaele Hospital were obtained within the Covid-BioB project and healthcare personnel of San Raffaele Hospital, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) clinical lab and clinical research Unit, funded by the Program Project COVID-19 OSR-UniSR and Fondazione Telethon. The French COVID Cohort study group was sponsored by Inserm and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). The Cov-Contact Cohort was supported by the REACTing consortium, the French Ministry of Health, and the European Commission (RECOVER WP 6). The 'Milieu Intérieur' cohort was supported by was supported by the French Government’s Investissement d’Avenir Program, Laboratoire d’Excellence 'Milieu Intérieur' Grant (ANR-10-LABX-69-01) (PI: L Quintana-Murci & D Duffy). The Simoa experiment was supported by the PHRC-20-0375 COVID-19 grant 'DIGITAL COVID' (PI: G Gorochov). SGT is supported by a Leadership 3 Investigator Grant awarded by the National Health and Medical Research Council of Australia, and a COVID19 Rapid Response Grant awarded by UNSW Sydney. CRG and colleagues were supported by Instituto de Salud Carlos III (COV20_01333 and COV20_01334, Spanish Ministry of Science and Innovation -RTC-2017-6471-1, AEI/FEDER, UE), and Cabildo Insular de Tenerife (CGIEU0000219140 and 'Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19'). SA and AB were supported by ANR-20-COVI-0064 (PI: A Belot). This work is supported by the French Ministry of Health 'Programme Hospitalier de Recherche Clinique Inter regional 2013', by the Contrat de Plan Etat-Lorraine and FEDER Lorraine, and a public grant overseen by the French National Research Agency (ANR) as part of the second 'Investissements d’Avenir' program FIGHT-HF (reference: ANR-15-RHU-0004) and by the French PIA project 'Lorraine Université d’Excellence', reference ANR-15-IDEX-04-LUE (45) and biobanking is performed by the Biological Resource Center Lorrain BB-0033-00035. This study was supported by the Fonds IMMUNOV, for Innovation in Immunopathology and by a grant from the Agence National de la Recherche (ANR-flash Covid19 'AIROCovid' to FRL), and by the FAST Foundation (French Friends of Sheba Tel Hashomer Hospital). Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1, a George Mason University Fast Grant, and the G. Harold and Leila Y. Mathers Charitable Foundation. The Amsterdam UMC Covid-19 Biobank was supported by grants of the Amsterdam Corona Research Fund, Dr. C.J. Vaillant Fund, and Netherlands Organization for Health Research and Development (ZonMw, NWO-Vici-Grant [grant number 918·19·627 to DvdB]. This work was also supported by the Division of Intramural Research of the National Institute of Dental Craniofacial Research and National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by Regione Lombardia, Italy (project 'Risposta immune in pazienti con COVID-19 e comorbidita'). The opinions and assertions expressed herein are those of the author(s) and do not necessarily reflect the official policy or position of the Uniformed Services University or the Department of Defense. JH holds an Institut Imagine MD-PhD fellowship from the Fondation Bettencourt Schueller. JR is supported by the Inserm PhD program ('poste d’accueil Inserm'). PB was supported by the French Foundation for Medical Research (FRM, EA20170638020) and the MD-PhD program of the Imagine Institute (with the support of the Fondation Bettencourt-Schueller). We thank the Association 'Turner et vous' for their help and support. Sample processing at IrsiCaixa was possible thanks to the crowdfunding initiative YoMeCorono. DCV is supported by the Fonds de la recherche en santé du Québec clinician-scientist scholar program. K. Kisand was supported by the Estonian Research Council grant PUT1367. We thank the GEN-COVID Multicenter Study (https://sites.google.com/dbm.unisi.it/gen-covid). We thank the NIAID Office of Cyber Infrastructure and Computational Biology, Bioinformatics and Computational Biosciences Branch (Contract HHSN316201300006W/HHSN27200002 to MSC, Inc) and Operations Engineering Branch for developing the HGRepo system to enable streamlined access to the data and the NCI Advanced Biomedical Computational Science (ABCS) for data transformation support., The Milieu Intérieur Consortium : Laurent Abel 1, Andres Alcover 2, Hugues Aschard 2, Kalla Astrom 3, Philippe Bousso 2, Pierre Bruhns 2, Ana Cumano 2, Caroline Demangel 2, Ludovic Deriano 2, James Di Santo 2, Françoise Dromer 2, Gérard Eberl 2, Jost Enninga 2, Jacques Fellay 4, Ivo Gomperts-Boneca 2, Milena Hasan 2, Serge Hercberg 5, Olivier Lantz 6, Hugo Mouquet 2, Etienne Patin 2, Sandra Pellegrini 2, Stanislas Pol 7, Antonio Rausell 8, Lars Rogge 2, Anavaj Sakuntabhai 2, Olivier Schwartz 2, Benno Schwikowski 2, Spencer Shorte 2, Frédéric Tangy 2, Antoine Toubert 9, Mathilde Touvier 10, Marie-Noëlle Ungeheuer 2, Matthew L. Albert 11*, Darragh Duffy 2*, Lluis Quintana-Murci 2* - 1INSERM U1163, University of Paris, Imagine Institute, Paris, France. 2Pasteur Institute, Paris, France. 3Lund University, Lund, Sweden. 4EPFL, Lausanne, Switzerland. 5Université Paris 13, Paris, France. 6Curie Institute, Paris, France. 7Cochin Hospital, Paris, France. 8INSERM UMR 1163 – Institut Imagine, Paris, France. 9Hôpital Saint-Louis, Paris, France. 10Sorbonne Paris Nord University, Inserm U1153, Inrae U1125, Cnam, Nutritional Epidemiology Research Team (EREN), Bobigny, France. 11In Sitro, San Francisco, CA, USA. *Co-coordinators of The Milieu Intérieur Consortium. Additional information can be found at: www.milieuinterieur.fr/en., Amsterdam UMC Covid-19 Biobank Michiel van Agtmael1, Anna Geke Algera2, Frank van Baarle2, Diane Bax3, Martijn Beudel4, Harm Jan Bogaard5, Marije Bomers1, Lieuwe Bos2, Michela Botta2, Justin de Brabander6, Godelieve Bree6, Matthijs C. Brouwer4, Sanne de Bruin2, Marianna Bugiani7, Esther Bulle2, Osoul Chouchane1, Alex Cloherty3, Paul Elbers2, Lucas Fleuren2, Suzanne Geerlings1, Bart Geerts8, Theo Geijtenbeek9, Armand Girbes2, Bram Goorhuis1, Martin P. Grobusch1, Florianne Hafkamp9, Laura Hagens2, Jorg Hamann10, Vanessa Harris1, Robert Hemke11, Sabine M. Hermans1, Leo Heunks2, Markus W. Hollmann8, Janneke Horn2, Joppe W. Hovius1, Menno D. de Jong12, Rutger Koning4, Niels van Mourik2, Jeaninne Nellen1, Frederique Paulus2, Edgar Peters1, Tom van der Poll1, Benedikt Preckel8, Jan M. Prins1, Jorinde Raasveld2, Tom Reijnders1, Michiel Schinkel1, Marcus J. Schultz2, Alex Schuurman13, Kim Sigaloff1, Marry Smit2, Cornelis S. Stijnis1, Willemke Stilma2, Charlotte Teunissen14, Patrick Thoral2, Anissa Tsonas2, Marc van der Valk1, Denise Veelo8, Alexander P. J. Vlaar15, Heder de Vries2, Michèle van Vugt1, W. Joost Wiersinga1, Dorien Wouters16, A. H. (Koos) Zwinderman17, Diederik van de Beek18* 1Department of Infectious Diseases, Amsterdam UMC, Amsterdam, Netherlands. 2Department of Intensive Care, Amsterdam UMC, Amsterdam, Netherlands. 3Experimental Immunology, Amsterdam UMC, Amsterdam, Netherlands. 4Department of Neurology, Amsterdam UMC, Amsterdam Neuroscience, Amsterdam, Netherlands. 5Department of Pulmonology, Amsterdam UMC, Amsterdam, Netherlands. 6Department of Infectious Diseases, Amsterdam UMC, Amsterdam, Netherlands. 7Department of Pathology, Amsterdam UMC, Amsterdam, Netherlands. 8Department of Anesthesiology, Amsterdam UMC, Amsterdam, Netherlands. 9Department of Experimental Immunology, Amsterdam UMC, Amsterdam, Netherlands. 10Amsterdam UMC, Netherlands Biobank Core Facility, Amsterdam UMC, Amsterdam, Netherlands. 11Department of Radiology, Amsterdam UMC, Amsterdam, Netherlands. 12Department of Medical Microbiology, Amsterdam UMC, Amsterdam, Netherlands. 13Department of Internal Medicine, Amsterdam UMC, Amsterdam, Netherlands. 14Neurochemical Laboratory, Amsterdam UMC, Amsterdam, Netherlands. 15Deparment of Intensive Care, Amsterdam UMC, Amsterdam, Netherlands. 16Department of Clinical Chemistry, Amsterdam UMC, Amsterdam, Netherlands. 17Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Amsterdam, Netherlands. 18Department of Neurology, Amsterdam UMC, Amsterdam, Netherlands. *Leader of the AMC consortium., COVID Human Genetic Effort Laurent Abel1, Alessandro Aiuti2, Saleh Al Muhsen3, Fahd Al-Mulla4, Mark S. Anderson5, Andrés Augusto Arias6, Hagit Baris Feldman7, Dusan Bogunovic8, Alexandre Bolze9, Anastasiia Bondarenko10, Ahmed A. Bousfiha11, Petter Brodin12, Yenan Bryceson12, Carlos D. Bustamante13, Manish Butte14, Giorgio Casari15, Samya Chakravorty16, John Christodoulou17, Elizabeth Cirulli9, Antonio Condino-Neto18, Megan A. Cooper19, Clifton L. Dalgard20, Joseph L. DeRisi21, Murkesh Desai22, Beth A. Drolet23, Sara Espinosa24, Jacques Fellay25, Carlos Flores26, Jose Luis Franco27, Peter K. Gregersen28, Filomeen Haerynck29, David Hagin30, Rabih Halwani31, Jim Heath32, Sarah E. Henrickson33, Elena Hsieh34, Kohsuke Imai35, Yuval Itan8, Timokratis Karamitros36, Kai Kisand37, Cheng-Lung Ku38, Yu-Lung Lau39, Yun Ling40, Carrie L. Lucas41, Tom Maniatis42, Davoud Mansouri43, Laszlo Marodi44, Isabelle Meyts45, Joshua D. Milner46, Kristina Mironska47, Trine Mogensen48, Tomohiro Morio49, Lisa F. P. Ng50, Luigi D. Notarangelo51, Giuseppe Novelli52, Antonio Novelli53, Cliona O'Farrelly54, Satoshi Okada55, Tayfun Ozcelik56, Rebeca Perez de Diego57, Anna M. Planas58, Carolina Prando59, Aurora Pujol60, Lluis Quintana-Murci61, Laurent Renia62, Alessandra Renieri63, Carlos Rodríguez-Gallego64, Vanessa Sancho-Shimizu65, Vijay Sankaran66, Kelly Schiabor Barrett9, Mohammed Shahrooei67, Andrew Snow68, Pere Soler-Palacín69, András N. Spaan70, Stuart Tangye71, Stuart Turvey72, Furkan Uddin73, Mohammed J. Uddin74, Diederik van de Beek75, Sara E. Vazquez76, Donald C. Vinh77, Horst von Bernuth78, Nicole Washington9, Pawel Zawadzki79, Helen C. Su51*, Jean-Laurent Casanova80* 1INSERM U1163, University of Paris, Imagine Institute, Paris, France. 2San Raffaele Telethon Institute for Gene Therapy, IRCCS Ospedale San Raffaele, Milan, Italy. 3King Saud University, Riyadh, Saudi Arabia. 4Dasman Diabetes Institute, Department of Genetics and Bioinformatics, Dasman, Kuwait. 5University of California, San Francisco, San Francisco, CA, USA. 6Universidad de Antioquia, Group of Primary Immunodeficiencies, Antioquia, Colombia. 7The Genetics Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 8Icahn School of Medicine at Mount Sinai, New York, NY, USA. 9Helix, San Mateo, CA, USA. 10Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine. 11Clinical Immunology Unit, Pediatric Infectious Disease Department, Faculty of Medicine and Pharmacy, Averroes University Hospital, LICIA Laboratoire d'immunologie clinique, d'inflammation et d'allergie, Hassann Ii University, Casablanca, Morocco. 12Karolinska Institute, Stockholm, Sweden. 13Stanford University, Stanford, CA, USA. 14University of California, Los Angeles, CA, USA. 15Medical Genetics, IRCCS Ospedale San Raffaele, Milan, Italy. 16Department of Pediatrics and Children’s Healthcare of Atlanta, Emory University, Atlanta, GA, USA. 17Murdoch Children's Research Institute, Victoria, Australia. 18University of São Paulo, São Paulo, Brazil. 19Washington University School of Medicine, St. Louis, MO, USA. 20The American Genome Center, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 21University of California San Francisco, Chan Zuckerberg Biohub, San Francisco, CA, USA. 22Bai Jerbai Wadia Hospital for Children, Mumbai, India. 23 School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. 24Instituto Nacional de Pediatria (National Institute of Pediatrics), Mexico City, Mexico. 25Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland. 26Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Canarian Health System, Santa Cruz de Tenerife, Spain. 27University of Antioquia, Medellín, Colombia. 28Feinstein Institute for Medical Research, Northwell Health USA, Manhasset, NY, USA. 29Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Edegem, Belgium. 30The Genetics Institute Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 31Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates. 32Institute for Systems Biology, Seattle, WA, USA. 33Children's Hospital of Philadelphia, Philadelphia, PA, USA. 34Anschutz Medical Campus, Aurora, CO, USA. 35Riken, Tokyo, Japan. 36Hellenic Pasteur Institute, Athens, Greece. 37University of Tartu, Tartu, Estonia. 38Chang Gung University, Taoyuan County, Taiwan. 39The University of Hong Kong, Hong Kong, China. 40Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. 41Yale School of Medicine, New Haven, CT, USA. 42New York Genome Center, New York, NY, USA. 43Shahid Beheshti University of Medical Sciences, Tehran, Iran. 44Semmelweis University Budapest, Budapest, Hungary. 45KU Leuven, Department of Immunology, Microbiology and Transplantation, Leuven, Belgium. 46Columbia University Medical Center, New York, NY, USA. 47University Clinic for Children's Diseases, Skopje, North Macedonia. 48Aarhus University, Aarhus, Denmark. 49Tokyo Medical & Dental University Hospital, Tokyo, Japan. 50Singapore Immunology Network, Singapore. 51National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 52Department of Biomedicine and Prevention, University of Rome 'Tor Vergata,' Rome, Italy. 53Bambino Gesù Children's Hospital, Rome, Italy. 54Trinity College, Dublin, Ireland. 55Hiroshima University, Hiroshima, Japan. 56Bilkent University, Ankara, Turkey. 57Laboratory of Immunogenetics of Human Diseases, Innate Immunity Group, IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain. 58IIBB-CSIC, IDIBAPS, Barcelona, Spain. 59Faculdades Pequeno Príncipe e Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil. 60Neurometabolic Diseases Laboratory, IDIBELL - Hospital Duran I Reynals, Catalan Institution for Research and Advanced Studies (ICREA), CIBERER U759, ISCiii Madrid Spain, Barcelona, Spain. 61Institut Pasteur (CNRS UMR2000) and Collège de France, Paris, France. 62Infectious Diseases Horizontal Technology Center and Singapore Immunology Network, Agency for Science Technology (A*STAR), Singapore. 63Medical Genetics, University of Siena, Italy, Genetica Medica, Azienda Ospedaliero-Universitaria Senese, GEN-COVID Multicenter Study, Italy. 64Hospital Universitario de Gran Canaria Dr Negrín, Canarian Health System, Canary Islands, Spain. 65Imperial College London, London, UK. 66Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. 67Saeed Pathobiology and Genetic Laboratory, Tehran, Iran. 68Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA. 69Hospital Universitari Vall d'Hebron, Barcelona, Spain. 70University Medical Center Utrecht, Amsterdam, Netherlands. 71Garvan Institute of Medical Research, Sydney, Australia. 72The University of British Columbia, Vancouver, Canada. 73Holy Family Red Crescent Medical College, Centre for Precision Therapeutics, NeuroGen Children's Healthcare, Genetics and Genomic Medicine Centre, NeuroGen Children's Healthcare, Dhaka, Bangladesh. 74Mohammed Bin Rashid University of Medicine and Health Sciences, College of Medicine, Dubai, United Arab Emirates, The Centre for Applied Genomics, Department of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada. 75Amsterdam UMC, University of Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam, Netherlands. 76University of California, San Francisco, San Francisco, CA, USA. 77McGill University Health Centre, Montreal, Canada. 78Charité - Berlin University Hospital Center, Berlin, Germany. 79Molecular Biophysics Division, Faculty of Physics, A. Mickiewicz University, Uniwersytetu Poznanskiego 2, Poznań, Poland. 80The Rockefeller University, Howard Hughes Medical Institute, Necker Hospital, New York, NY, USA. *Leaders of the COVID Human Genetic Effort., ANR-10-LABX-0062,IBEID,Biologie Intégrative des Maladies Infectieuses Emergentes(2011), ANR-10-LABX-0020,NUMEV,Digital and Hardware Solutions and Modeling for the Environement and Life Sciences(2010), European Project: 101003589, H2020-SC1-PHE-CORONAVIRUS-2020,RECOVER(2020), Pulmonary medicine, Medical Microbiology and Infection Prevention, Internal medicine, Intensive care medicine, APH - Quality of Care, and Özçelik, Tayfun
- Subjects
Male ,COVID19 ,Immunoglobulin G ,DISEASE ,MESH: Antibodies, Neutralizing ,0302 clinical medicine ,MESH: Interferon alpha-2 ,80 and over ,Medicine ,Asymptomatic Infections ,MESH: Immunoglobulin G ,Aged, 80 and over ,0303 health sciences ,MESH: Middle Aged ,COVID Clinicians ,MESH: Case-Control Studies ,3. Good health ,Settore MED/03 ,030220 oncology & carcinogenesis ,MESH: Critical Illness ,Interferon Type I ,Science & Technology - Other Topics ,Viral disease ,MESH: Pandemics ,[SDV.IMM] Life Sciences [q-bio]/Immunology ,Critical Illness ,Immunology ,Pneumonia, Viral ,Interferon alpha-2 ,HGID Lab ,03 medical and health sciences ,Betacoronavirus ,Genetics ,Humans ,MESH: SARS-CoV-2 ,COVID Human Genetic Effort ,Aged ,Autoantibodies ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,MESH: Humans ,Science & Technology ,CYTOKINES ,MESH: Adult ,Pneumonia ,medicine.disease ,Antibodies, Neutralizing ,COVID-STORM Clinicians ,MESH: Pneumonia, Viral ,Case-Control Studies ,NIAID-USUHS Immune Response to COVID Group ,MESH: Female ,MESH: Interferon Type I ,MESH: Coronavirus Infections ,CHRONIC MUCOCUTANEOUS CANDIDIASIS ,[SDV.GEN] Life Sciences [q-bio]/Genetics ,medicine.disease_cause ,Autoimmunity ,CoV-Contact Cohort ,MESH: Aged, 80 and over ,[SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] ,Medicine and Health Sciences ,MESH: Autoantibodies ,MESH: COVID-19 ,Online ,Viral ,Chronic mucocutaneous candidiasis ,Imagine COVID Group ,Amsterdam UMC Covid-19 Biobank ,Neutralizing ,Research Articles ,MESH: Aged ,Multidisciplinary ,biology ,Middle Aged ,Multidisciplinary Sciences ,Milieu Intérieur Consortium ,MESH: Betacoronavirus ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Female ,medicine.symptom ,Coronavirus Infections ,Research Article ,Sciences exactes et naturelles ,Adult ,INTERFERON ,General Science & Technology ,PROTEINS ,French COVID Cohort Study Group ,MESH: Asymptomatic Infections ,COVID-19 ,Pandemics ,SARS-CoV-2 ,Asymptomatic ,Antibodies ,[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,030304 developmental biology ,Phenocopy ,business.industry ,R-Articles ,Autoantibody ,GAMMA ,MESH: Male ,3121 General medicine, internal medicine and other clinical medicine ,ANTIBODIES ,biology.protein ,3111 Biomedicine ,business - Abstract
HGID Lab Andrés Augusto Arias1,3, Bertrand Boisson1,2, Soraya Boucherit2, Jacinta Bustamante1,2, Marwa Chbihi2, Jie Chen1, Maya Chrabieh2, Tatiana Kochetkov1, Tom Le Voyer2, Dana Liu1, Yelena Nemirovskaya1, Masato Ogishi1, Dominick Papandrea1, Cécile Patissier2, Franck Rapaport1, Manon Roynard2, Natasha Vladikine2, Mark Woollett1, Peng Zhang1 1St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University. 2Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children. 3School of Microbiology and Group of Primary Immunodeficiencies, University of Antioquia UdeA, Medellin, Colombia., NIAID-USUHS Immune Response to COVID Group Anuj Kashyap1, Li Ding1, Marita Bosticardo1, Qinlu Wang2, Sebastian Ochoa1, Hui Liu1, Samuel D. Chauvin3, Michael Stack1, Galina Koroleva4, Neha Bansal5, Clifton L. Dalgard6,7, Andrew L. Snow8 1Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. 2Bioinformatics and Computational Biosciences Branch, NIAID Office of Cyber Infrastructure and Computational Biology, NIAID, NIH, Bethesda, MD, USA. 3Laboratory of Immune System Biology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA. 4NIH Center for Human Immunology, NIH, Bethesda, MD, USA. 5Multiscale Systems Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA. 6PRIMER, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 7Department of Anatomy, Physiology & Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 8Department of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA., COVID Clinicians Jorge Abad1, Sergio Aguilera-Albesa2, Ozge Metin Akcan3, Ilad Alavi Darazam4, Juan C. Aldave5, Miquel Alfonso Ramos6, Seyed Alireza Nadji7, Gulsum Alkan8, Jerome Allardet-Servent9, Luis M. Allende10, Laia Alsina11, Marie-Alexandra Alyanakian12, Blanca Amador-Borrero13, Zahir Amoura14, Arnau Antolí15, Sevket Arslan16, Sophie Assant17, Terese Auguet18, Axelle Azot19, Fanny Bajolle20, Aurélie Baldolli21, Maite Ballester22, Hagit Baris Feldman23, Benoit Barrou24, Alexandra Beurton25, Agurtzane Bilbao26, Geraldine Blanchard-Rohner27, Ignacio Blanco1, Adeline Blandinières28, Daniel Blazquez-Gamero29, Marketa Bloomfield30, Mireia Bolivar-Prados31, Raphael Borie32, Ahmed A. Bousfiha33, Claire Bouvattier34, Oksana Boyarchuk35, Maria Rita P. Bueno36, Jacinta Bustamante20, Juan José Cáceres Agra37, Semra Camli38, Ruggero Capra39, Maria Carrabba40, Carlos Casasnovas41, Marion Caseris42, Martin Castelle43, Francesco Castelli44, Martín Castillo de Vera45, Mateus V. Castro36, Emilie Catherinot46, Martin Chalumeau47, Bruno Charbit48, Matthew P. Cheng49, Père Clavé31, Bonaventura Clotet50, Anna Codina51, Fatih Colkesen52, Fatma Colkesen53, Roger Colobran 54, Cloé Comarmond55, Angelo G. Corsico56, David Dalmau57, David Ross Darley58, Nicolas Dauby59, Stéphane Dauger60, Loic de Pontual61, Amin Dehban62, Geoffroy Delplancq63, Alexandre Demoule64, Antonio Di Sabatino65, Jean-Luc Diehl66, Stephanie Dobbelaere67, Sophie Durand68, Waleed Eldars69, Mohamed Elgamal70, Marwa H. Elnagdy71, Melike Emiroglu72, Emine Hafize Erdeniz73, Selma Erol Aytekin74, Romain Euvrard75, Recep Evcen76, Giovanna Fabio40, Laurence Faivre77, Antonin Falck42, Muriel Fartoukh78, Morgane Faure79, Miguel Fernandez Arquero80, Carlos Flores81, Bruno Francois82, Victoria Fumadó83, Francesca Fusco84, Blanca Garcia Solis85, Pascale Gaussem86, Juana Gil-Herrera87, Laurent Gilardin88, Monica Girona Alarcon89, Mónica Girona-Alarcón89, Jean-Christophe Goffard90, Funda Gok91, Rafaela González-Montelongo92, Antoine Guerder93, Yahya Gul94, Sukru Nail Guner94, Marta Gut95, Jérôme Hadjadj96, Filomeen Haerynck97, Rabih Halwani98, Lennart Hammarström99, Nevin Hatipoglu100, Elisa Hernandez-Brito101, María Soledad Holanda-Peña102, Juan Pablo Horcajada103, Sami Hraiech104, Linda Humbert105, Alejandro D. Iglesias106, Antonio Íñigo-Campos92, Matthieu Jamme107, María Jesús Arranz108, Iolanda Jordan109, Fikret Kanat110, Hasan Kapakli111, Iskender Kara112, Adem Karbuz113, Kadriye Kart Yasar114, Sevgi Keles115, Yasemin Kendir Demirkol116, Adam Klocperk117, Zbigniew J. Król118, Paul Kuentz119, Yat Wah M. Kwan120, Jean-Christophe Lagier121, Yu-Lung Lau122, Fleur Le Bourgeois60, Yee-Sin Leo123, Rafael Leon Lopez124, Daniel Leung122, Michael Levin125, Michael Levy60, Romain Lévy20, Zhi Li48, Agnes Linglart126, José M. Lorenzo-Salazar92, Céline Louapre127, Catherine Lubetzki127, Charles-Edouard Luyt128, David C. Lye129, Davood Mansouri130, Majid Marjani131, Jesus Marquez Pereira132, Andrea Martin133, David Martínez Pueyo134, Javier Martinez-Picado135, Iciar Marzana136, Alexis Mathian14, Larissa R. B. Matos36, Gail V. Matthews137, Julien Mayaux138, Jean-Louis Mège139, Isabelle Melki140, Jean-François Meritet141, Ozge Metin142, Isabelle Meyts143, Mehdi Mezidi144, Isabelle Migeotte145, Maude Millereux146, Tristan Mirault147, Clotilde Mircher68, Mehdi Mirsaeidi148, Abián Montesdeoca Melián149, Antonio Morales Martinez150, Pierre Morange151, Demence Mordacq105, Guillaume Morelle152, Stéphane Mouly13, Adrián Muñoz-Barrera92, Cyril Nafati153, João Farela Neves154, Lisa F. P. Ng155, Yeray Novoa Medina156, Esmeralda Nuñez Cuadros157, J. Gonzalo Ocejo-Vinyals158, Zerrin Orbak159, Mehdi Oualha20, Tayfun Özçelik160, Qiang Pan Hammarström161, Christophe Parizot138, Tiffany Pascreau162, Estela Paz-Artal163, Sandra Pellegrini48, Rebeca Pérez de Diego85, Aurélien Philippe164, Quentin Philippot78, Laura Planas-Serra165, Dominique Ploin166, Julien Poissy167, Géraldine Poncelet42, Marie Pouletty168, Paul Quentric138, Didier Raoult139, Anne-Sophie Rebillat68, Ismail Reisli169, Pilar Ricart170, Jean-Christophe Richard171, Nadia Rivet28, Jacques G. Rivière172, Gemma Rocamora Blanch15, Carlos Rodrigo1, Carlos Rodriguez-Gallego173, Agustí Rodríguez-Palmero174, Carolina Soledad Romero175, Anya Rothenbuhler176, Flore Rozenberg177, Maria Yolanda Ruiz del Prado178, Joan Sabater Riera15, Oliver Sanchez179, Silvia Sánchez-Ramón180, Agatha Schluter165, Matthieu Schmidt181, Cyril E. Schweitzer182, Francesco Scolari183, Anna Sediva184, Luis M. Seijo185, Damien Sene13, Sevtap Senoglu114, Mikko Seppänen186, Alex Serra Ilovich187, Mohammad Shahrooei62, David Smadja188, Ali Sobh189, Xavier Solanich Moreno15, Jordi Solé-Violán190, Catherine Soler191, Pere Soler-Palacín133, Yuri Stepanovskiy192, Annabelle Stoclin193, Fabio Taccone145, Yacine Tandjaoui-Lambiotte194, Jean-Luc Taupin195, Simon J. Tavernier196, Benjamin Terrier197, Caroline Thumerelle105, Gabriele Tomasoni198, Julie Toubiana47, Josep Trenado Alvarez199, Sophie Trouillet-Assant200, Jesús Troya201, Alessandra Tucci202, Matilde Valeria Ursini84, Yurdagul Uzunhan203, Pierre Vabres204, Juan Valencia-Ramos205, Ana Maria Van Den Rym85, Isabelle Vandernoot206, Hulya Vatansev207, Valentina Vélez-Santamaria41, Sébastien Viel166, Cédric Vilain208, Marie E. Vilaire68, Audrey Vincent34, Guillaume Voiriot209, Fanny Vuotto105, Alper Yosunkaya91, Barnaby E. Young123, Fatih Yucel210, Faiez Zannad211, Mayana Zatz36, Alexandre Belot212* 1University Hospital and Research Institute “Germans Trias i Pujol”, Badalona, Spain. 2Navarra Health Service Hospital, Pamplona, Spain. 3Division of Pediatric Infectious Diseases, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. 4Department of Infectious Diseases, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru. 6Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat Spain. 7Virology Research Center, National institutes of Tuberculosis and Lung diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 8Division of Pediatric Infectious Diseases, Faculty of Medicine, Selcuk University, Konya, Turkey. 9Intensive care unit, Hôpital Européen, Marseille, France. 10Immunology Department, University Hospital 12 de Octubre. Research Institute imas12. Complutense University, Madrid, Spain. 11Hospital Sant Joan de Déu, Barcelona, Spain. 12Department of Biological Immunology, Necker Hospital for Sick Children, APHP and INEM, Paris, France. 13Internal medicine department, Hôpital Lariboisière, APHP; Université de Paris, Paris, France. 14Internal medicine department, Pitié-Salpétrière Hospital, Paris, France. 15Hospital Universitari de Bellvitge, Barcelona, Spain. 16Division of Clinical Immunology and Allergy, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. 17Joint Research Unit, Hospices Civils de Lyon-bio Mérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Lyon, France. 18Hospital U. de Tarragona Joan XXIII. Universitat Rovira i Virgili (URV). IISPV, Tarragona, Spain. 19Private practice, Paris, France. 20Necker Hospital for Sick Children, AP-HP, Paris, France. 21Department of Infectious Diseases, CHU de Caen, Caen, France. 22Consorcio Hospital General Universitario, Valencia, Spain. 23The Genetics Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 24Dept Urology, Nephrology, Transplantation, APHP-SU, Sorbonne Université, INSERM U 1082, Paris, France. 25Service de Médecine Intensive–Réanimation et Pneumologie, APHP Hôpital Pitié–Salpêtrière, Paris, France. 26Cruces University Hospital, Bizkaia, Spain. 27Paediatric Immunology and Vaccinology Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland. 28Hematology, Georges Pompidou Hospital, APHP, Paris, France. 29Pediatric Infectious Diseases Unit. Instituto de Investigación 12 de Octubre (imas12). Hospital Universitario 12 de Octubre, Madrid, Spain. 30Department of Immunology, Motol University Hospital, 2nd Faculty of Medicine, Charles University, Department of Pediatrics, Thomayer’s Hospital, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. 31Centro de Investigación Biomédica en Red de Enfermedades Hepàticas y Digestivas (Ciberehd). Hospital de Mataró, Consorci Sanitari del Maresme, Mataró, Spain. 32Service de Pneumologie, Hopital Bichat, APHP, Paris, France. 33Clinical immunology unit, pediatric infectious disease departement, Faculty of Medicine and Pharmacy, Averroes University Hospital. LICIA Laboratoire d'immunologie clinique, d'inflammation et d'allergie, Hassann Ii University, Casablanca, Morocco. 34Endocrinology unit, APHP Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, France. 35Department of Children's Diseases and Pediatric Surgery, I.Horbachevsky Ternopil National Medical University, Ternopil, Ukraine. 36Human Genome and stem-cell research center- University of São Paulo, São Paulo, Brazil. 37Hospital Insular, Las Palmas de Gran Canaria, Spain. 38Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Konya State Hospital, Konya, Turkey. 39MS Center, Spedali Civili, Brescia, Italy. 40Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. 41Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain. 42Hopital Robert Debré, Paris, France. 43Pediatric Immuno-hematology Unit, Necker Enfants Malades Hospital, AP-HP, Paris, France. 44Department of Infectious and Tropical Diseases, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. 45Doctoral Health Care Center, Canarian Health System, Las Palmas de Gran Canaria, Spain. 46Hôpital Foch, Suresnes, France. 47Necker Hospital for Sick Children, Paris University, AP-HP, Paris, France. 48Pasteur Institute, Paris, France. 49McGill University Health Centre, Montreal, Canada. 50University Hospital and Research Institute “Germans Trias i Pujol”, IrsiCaixa AIDS Research Institute, UVic-UCC, Badalona, Spain. 51Clinical Biochemistry, Pathology, Paediatric Neurology and Molecular Medicine Departments and Biobank, Institut de Recerca Sant Joan de Déu and CIBERER-ISCIII, Esplugues, Spain. 52Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. 53Department of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey. 54Hospital Universitari Vall d’Hebron, Barcelona, Spain. 55Pitié-Salpêtrière Hospital, Paris, France. 56Respiratory Diseases Division, IRCCS Policlinico San Matteo Foundation and University of Pavia, Pavia, Italy. 57Fundació Docència i Recerca Mútua Terrassa, Barcelona, Spain. 58UNSW Medicine, St Vincent's Clinical School; Department of Thoracic Medicine, St Vincent's Hospital Darlinghurst, Sidney, Australia. 59CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium. 60Pediatric Intensive Care Unit, Robert-Debré University Hospital, APHP, Paris, France. 61Sorbonne Paris Nord, Hôpital Jean Verdier, APHP, Bondy, France. 62Specialized Immunology Laboratory of Dr. Shahrooei, Sina Medical Complex, Ahvaz, Iran. 63Centre de génétique humaine, CHU Besançon, Besançon, France. 64Sorbonne Université médecine and APHP Sorbonne université site Pitié-Salpêtrière, Paris, France. 65Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy. 66Intensive Care unit, Georges Pompidou Hospital, APHP, Paris, France. 67Department of Pneumology, AZ Delta, Roeselare, Belgium. 68Institut Jérôme Lejeune, Paris, France. 69Department of Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. 70Department of Chest, Faculty of Medicine, Mansoura University, Mansoura, Egypt. 71Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. 72Faculty of Medicine, Division of Pediatric Infectious Diseases, Selcuk University, Konya, Turkey. 73Division of Pediatric Infectious Diseases, Ondokuz Mayıs University, Samsun, Turkey. 74Necmettin Erbakan University, Meram Medical Faculty, Division of Pediatric Allergy and Immunology, Konya, Turkey. 75Centre Hospitalier Fleyriat, Bourg-en-Bresse, France. 76Division of Clinical Immunology and Allergy, Department of Internal Medicine, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. 77Centre de Génétique, CHU Dijon, Dijon, France. 78APHP Tenon Hospital, Paris, France. 79Sorbonne Universités, UPMC University of Paris, Paris, France. 80Department of Clinical Immunology, Hospital Clínico San Carlos, Madrid, Spain. 81Genomics Division, Instituto Tecnológico y de Energías Renovables (ITER), Santa Cruz de Tenerife, Spain; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain; Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, San Cristóbal de La Laguna, Spain. 82CHU Limoges and Inserm CIC 1435 & UMR 1092, Limoges, France. 83Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Déu, Barcelona, Spain; Institut de Recerca Sant Joan de Déu, Spain; Universitat de Barcelona (UB), Barcelona, Spain. 84Institute of Genetics and Biophysics ‘Adriano Buzzati-Traverso’, IGB-CNR, Naples, Italy. 85Laboratory of Immunogenetics of Human Diseases, IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain. 86Hematology, APHP, Hopital Européen Georges Pompidou and Inserm UMR-S1140, Paris, France. 87Hospital General Universitario and Instituto de Investigación Sanitaria "Gregorio Marañón", Madrid, Spain. 88Bégin military Hospital, Bégin, France. 89Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Barcelona, Spain. 90Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. 91Division of Critical Care Medicine, Department of Anesthesiology and Reanimation, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. 92Genomics Division, Instituto Tecnológico y de Energías Renovables (ITER), Santa Cruz de Tenerife, Spain. 93Assistance Publique Hôpitaux de Paris, Paris, France. 94Division of Allergy and Immunology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. 95CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST); Universitat Pompeu Fabra (UPF), Barcelona, Spain. 96Department of Internal Medicine, National Reference Center for Rare Systemic Autoimmune Diseases, AP-HP, APHP-CUP, Hôpital Cochin, Paris, France. 97Ghent University Hospital, Ghent, Belgium. 98Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE. 99Department of Biosciences and Nutrition, SE14183, Huddinge, Karolinska Institutet, Stockholm, Sweden. 100Pediatric Infectious Diseases Unit, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 101Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. 102IntensivenCare Unit. Marqués de Valdecilla Hospital, Santander, Spain. 103Hospital del Mar, Parc de Salut Mar, Barcelona, Spain. 104Intensive care unit, APHM, Marseille, France. 105CHU Lille, Lille, France. 106Department of Pediatrics, Columbia University, New York, NY, USA. 107Centre hospitalier intercommunal Poissy Saint Germain en Laye, Poissy, France. 108Division of Respiratory Diseases, Fundació Docència i Recerca Mútua Terrassa, Barcelona, Spain. 109Hospital Sant Joan de Déu, Kids Corona Platfform, Barcelona, Spain. 110Selcuk University, Faculty of Medicine, Chest Diseases Department, Konya, Turkey. 111Division of Allergy and Immunology, Balikesir Ataturk City Hospital, Balikesir, Turkey. 112Division of Critical Care Medicine, Selcuk University, Faculty of Medicine, Konya, Turkey. 113Division of Pediatric Infectious Diseases, Prof. Dr. Cemil Tascıoglu City Hospital, Istanbul, Turkey. 114Departments of Infectious Diseases and Clinical Microbiology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. 115Meram Medical Faculty, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. 116Health Sciences University, Umraniye Education and Research Hospital, Istanbul, Turkey. 117Department of Immunology, 2nd Faculty of Medicine, Charles University and University Hospital in Motol, Prague, Czech Republic. 118Central Clinical Hospital of Ministry of the Interior and Administration in Warsaw, Warsaw, Poland. 119Oncobiologie Génétique Bioinformatique, PC Bio, CHU Besançon, Besançon, France. 120Paediatric Infectious Disease Unit, Hospital Authority Infectious Disease Center, Princess Margaret Hospital, Hong Kong (Special Administrative Region), China. 121Aix Marseille Univ, IRD, MEPHI, IHU Méditerranée Infection, Marseille, France. 122Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, China. 123National Centre for Infectious Diseases, Singapore. 124Hospital Universitario Reina Sofía, Cordoba, Spain. 125Imperial College, London, England. 126Endocrinology and diabetes for children, AP-HP, Bicêtre Paris-Saclay hospital, Le Kremlin-Bicêtre, France. 127Neurology unit, APHP Pitié-Salpêtrière Hospital, Paris University, Paris, France. 128Intensive care unit, APHP Pitié-Salpêtrière Hospital, Paris University, Paris, France. 129National Centre for Infectious Diseases; Tan Tock Seng Hospital; Yong Loo Lin School of Medicine; Lee Kong Chian School of Medicine, Singapore. 130Department of Clinical Immunology and Infectious Diseases, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 131Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. 132Hospital Sant Joan de Déu and University of Barcelona, Barcelona, Spain. 133Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Vall d'Hebron Research Institute, Vall d’Hebron Barcelona Hospital Campus. Universitat Autònoma de Barcelona (UAB), Barcelona, Spain. 134Hospital Universitari Mutua de Terrassa, Universitat de Barcelona, Barcelona, Spain. 135IrsiCaixa AIDS Research Institute, ICREA, UVic-UCC, Research Institute “Germans Trias i Pujol”, Badalona, Spain. 136Department of Laboratory, Cruces University Hospital, Barakaldo, Bizkaia, Spain. 137University of New South Wales, Australia. 138APHP Pitié-Salpêtrière Hospital, Paris, France. 139Aix-Marseille University, APHM, Marseille, France. 140Robert Debré Hospital, Paris, France. 141APHP Cohin Hospital, Paris, France. 142Necmettin Erbakan University Meram Faculty of Medicine Department of Pediatric Infectious Diseases, Konya, Turkey. 143University Hospitals Leuven, Leuven, Belgium. 144Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Lyon, France. 145Hôpital Erasme, Brussels, Belgium. 146CH Gonesse, Gonesse, France. 147Vascular Medicine, Georges Pompidou Hospital, APHP, Paris, France. 148Division of Pulmonary and Critical Care, University of Miami, Miami, USA. 149Guanarteme Health Care Center, Canarian Health System, Las Palmas de Gran Canaria, Spain. 150Regional University Hospital of Malaga, Malaga, Spain. 151Aix-Marseille Université, Marseille, France. 152Department of General Paediatrics, Hôpital Bicêtre, AP-HP, University of Paris Saclay, Le Kremlin-Bicêtre, France. 153CHU de La Timone, Marseille, France. 154Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal. 155Infectious Diseases Horizontal Technlogy Centre, A*STAR; Singapore Immunology Network, A*STAR, Singapore. 156Department of Pediatrics, Complejo Hospitalario Universitario Insular-Materno Infantil, Canarian Health System, Las Palmas de Gran Canaria, Spain. 157Regional Universitary Hospital of Malaga, Málaga, Spain. 158Hospital Universitario Marqués de Valdecilla, Santander, Spain. 159Ataturk University Medical Faculty, Erzurum, Turkey. 160Bilkent University, Department of Molecular Biology and Genetics, Ankara, Turkey. 161Department of Laboratory Medicine, Karolinska Institutet, SE14186, Stockholm, Sweden. 162L'Hôpital Foch, Suresnes, France. 163Department of Immunology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain. 164APHP Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, France. 165Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, Barcelona; CIBERER U759, ISCiii Madrid, Spain. 166Hospices Civils de Lyon, Lyon, France. 167Université de Lille, Inserm U1285, CHU Lille, Paris, France. 168Departement of General Pediatrics, University Hospital Robert Debré, APHP, Paris, France. 169Necmettin Erbakan University, Konya, Turkey. 170Germans Trias i Pujol Hospital, Badalona, Spain. 171Medical intensive care unit. Hopital de la Croix-Rousse. Hospices Civils de Lyon, Lyon, France. 172Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d’Hebron, Vall d'Hebron Research Institute, Vall d’Hebron Barcelona Hospital Campus., Barcelona, Spain. 173Department of Immunology, Hospital Universitario de Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain, EU. University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain. 174Neurometabolic Diseases Laboratory, IDIBELL-Hospital Duran i Reynals, Barcelona, Spain. 175Consorcio Hospital General Universitario, Valencia, Spain. 176APHP Hôpitaux Universitaires Paris-Sud, Paris, France. 177Virology unit, Université de Paris, Cohin Hospital, APHP, Paris, France. 178Hospital San Pedro, Logroño, Spain. 179Respiratory medicine, Georges Pompidou Hospital, APHP, Paris, France. 180Dept. Immunology, Hospital Clínico San Carlos, Madrid, Spain. 181Service de Médecine Intensive Réanimation, Institut de Cardiologie, Hopital Pitié-Salpêtrière, Paris, France. 182CHRU de Nancy, Hôpital d'Enfants, Vandoeuvre, France. 183Chair of Nephrology, University of Brescia, Brescia, Italy. 184Department of Immunology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic. 185Clínica Universidad de Navarra, Madrid, Spain. 186HUS Helsinki University Hospital, Children and Adolescents, Rare Disease Center, and Inflammation Center, Adult Immunodeficiency Unit, Majakka, Helsinki, Finland. 187Fundació Docència i Recerca Mútua Terrassa, Terrassa, Spain. 188Hopital Européen Georges Pompidou, Paris, France. 189Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt. 190Critical Care Unit, Hospital Universitario de Gran Canaria Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain. 191CHU de Saint Etienne, Saint-Priest-en-Jarez, France. 192Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine. 193Gustave Roussy Cancer Campus, Villejuif, France. 194Intensive Care Unit, Avicenne Hospital, APHP, Bobigny, France. 195Laboratory of Immunology and Histocompatibility, Saint-Louis Hospital, Paris University, Paris, France. 196Department of Internal Diseases and Pediatrics, Primary Immune Deficiency Research Lab, Centre for Primary Immunodeficiency Ghent, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Ghent, Belgium. 197Department of Internal Medicine, Université de Paris, INSERM, U970, PARCC, F-75015, Paris, France. 198First Division of Anesthesiology and Critical Care Medicine, University of Brescia, ASST Spedali Civili di Brescia, Brescia, Italy. 199Intensive Care Department, Hospital Universitari MutuaTerrassa, Universitat Barcelona, Terrassa, Spain. 200Hospices Civils de Lyon, Lyon Sud Hospital, Lyon, France. 201Infanta Leonor University Hospital, Madrid, Spain. 202Hematology Department, ASST Spedali Civili di Brescia, Brescia, Italy. 203Pneumologie, Hôpital Avicenne, APHP, INSERM U1272, Université Sorbonne Paris Nord, Bobigny, France. 204Dermatology unit, Laboratoire GAD, INSERM UMR1231 LNC, université de Bourgogne, Dijon, France. 205University Hospital of Burgos, Burgos, Spain. 206Center of Human Genetics, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. 207Department of Chest Diseases, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey. 208CHU de Caen, Caen, France. 209Sorbonne Université, Service de Médecine Intensive Réanimation, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France. 210General Intensive Care Unit, Konya Training and Research Hospital, Konya, Turkey. 211CHU de Nancy, Nancy, France. 212University of Lyon, CIRI, INSERM U1111, National referee centre RAISE, Pediatric Rheumatology, HFME, Hospices Civils de Lyon, Lyon, France. *Leader of the COVID-clinicians group., COVID-STORM Clinicians Giuseppe Foti1, Giacomo Bellani1, Giuseppe Citerio1, Ernesto Contro1, Alberto Pesci2, Maria Grazia Valsecchi3, Marina Cazzaniga4 1Department of Emergency, Anesthesia and Intensive Care, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza IT. 2Department of Pneumology, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza IT. 3Center of Bioinformatics and Biostatistics, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza IT. 4Phase I Research Center, School of Medicine and Surgery, University of Milano-Bicocca, San Gerardo Hospital, Monza IT., Imagine COVID Group Christine Bole-Feysot1, Stanislas Lyonnet1*, Cécile Masson1, Patrick Nitschke1, Aurore Pouliet1, Yoann Schmitt1, Frederic Tores1, Mohammed Zarhrate1 1Imagine Institute, Université de Paris, INSERM UMR 1163, Paris, France. *Leader of the Imagine COVID group., French COVID Cohort Study Group Laurent Abel1, Claire Andrejak2, François Angoulvant3, Delphine Bachelet4, Romain Basmaci5, Sylvie Behillil6, Marine Beluze7, Dehbia Benkerrou8, Krishna Bhavsar4, François Bompart9, Lila Bouadma4, Maude Bouscambert10, Mireille Caralp11, Minerva Cervantes-Gonzalez12, Anissa Chair4, Alexandra Coelho13, Camille Couffignal4, Sandrine Couffin-Cardiergues14, Eric D’ortenzio12, Charlene Da Silveira4, Marie-Pierre Debray4, Dominique Deplanque15, Diane Descamps16, Mathilde Desvallées17, Alpha Diallo18, Alphonsine Diouf13, Céline Dorival8, François Dubos19, Xavier Duval4, Philippine Eloy4, Vincent V. E. Enouf20, Hélène Esperou21, Marina Esposito-Farese4, Manuel Etienne22, Nadia Ettalhaoui4, Nathalie Gault4, Alexandre Gaymard10, Jade Ghosn4, Tristan Gigante23, Isabelle Gorenne4, Jérémie Guedj24, Alexandre Hoctin13, Isabelle Hoffmann4, Salma Jaafoura21, Ouifiya Kafif4, Florentia Kaguelidou25, Sabina Kali4, Antoine Khalil4, Coralie Khan17, Cédric Laouénan4, Samira Laribi4, Minh Le4, Quentin Le Hingrat4, Soizic Le Mestre18, Hervé Le Nagard24, François-Xavier Lescure4, Yves Lévy26, Claire Levy-Marchal27, Bruno Lina10, Guillaume Lingas24, Jean Christophe Lucet4, Denis Malvy28, Marina Mambert13, France Mentré4, Noémie Mercier18, Amina Meziane8, Hugo Mouquet20, Jimmy Mullaert4, Nadège Neant24, Marion Noret29, Justine Pages30, Aurélie Papadopoulos21, Christelle Paul18, Nathan Peiffer-Smadja4, Ventzislava Petrov-Sanchez18, Gilles Peytavin4, Olivier Picone31, Oriane Puéchal12, Manuel Rosa-Calatrava10, Bénédicte Rossignol23, Patrick Rossignol32, Carine Roy4, Marion Schneider4, Caroline Semaille12, Nassima Si Mohammed4, Lysa Tagherset4, Coralie Tardivon4, Marie-Capucine Tellier4, François Téoulé8, Olivier Terrier10, Jean-François Timsit4, Théo Treoux4, Christelle Tual33, Sarah Tubiana4, Sylvie van der Werf34, Noémie Vanel35, Aurélie Veislinger33, Benoit Visseaux16, Aurélie Wiedemann26, Yazdan Yazdanpanah36 1Inserm UMR 1163, Paris, France. 2CHU Amiens, France. 3Hôpital Necker, Paris, France. 4Hôpital Bichat, Paris, France. 5Hôpital Louis Mourrier, Colombes, France. 6Institut Pasteur, Paris, France. 7F-CRIN Partners Platform, AP-HP, Université de Paris, Paris, France. 8Inserm UMR 1136, Paris, France. 9Drugs for Neglected Diseases initiative, Geneva, Switzerland. 10Inserm UMR 1111, Lyon, France. 11Inserm Transfert, Paris, France. 12REACTing, Paris, France. 13Inserm UMR 1018, Paris, France. 14Inserm, Pôle Recherche Clinique, France. 15CIC 1403 Inserm-CHU Lille, Paris, France. 16Université de Paris, IAME, INSERM UMR 1137, AP-HP, University hospital Bichat Claude Bernard, Virology, F-75018 Paris, France. 17Inserm UMR 1219, Bordeaux, France. 18ANRS, Paris, France. 19CHU Lille, France. 20Pasteur Institute, Paris, France. 21Inserm sponsor, Paris, France. 22Rouen - SMIT, France. 23FCRIN INI-CRCT, Nancy, France. 24Inserm UMR 1137, Paris, France. 25Centre d'Investigation Clinique, Inserm CIC1426, Hôpital Robert Debré, Paris, France. 26Inserm UMR 955, Créteil, France; Vaccine Research Instiute (VRI), Paris, France. 27F-CRIN INI-CRCT, Paris, France. 28Bordeaux - SMIT, France. 29RENARCI, Annecy, France. 30Hôpital Robert Debré, Paris, France. 31Colombes - Louis Mourier - Gynécologie, France. 32University of Lorraine, Plurithematic Clinical Investigation Centre Inserm CIC-P; 1433, Inserm U1116, CHRU Nancy Hopitaux de Brabois, F-CRIN INI-CRCT; (Cardiovascular and Renal Clinical Trialists), Nancy, France. 33Inserm CIC-1414, Rennes, France. 34Institut Pasteur, UMR 3569 CNRS, Université de Paris, Paris, France. 35hôpital la timone, Marseille, France. 36Paris - Bichat - SMIT, France., The Milieu Intérieur Consortium Laurent Abel1, Andres Alcover2, Hugues Aschard2, Kalla Astrom3, Philippe Bousso2, Pierre Bruhns2, Ana Cumano2, Caroline Demangel2, Ludovic Deriano2, James Di Santo2, Françoise Dromer2, Gérard Eberl2, Jost Enninga2, Jacques Fellay4, Ivo Gomperts-Boneca2, Milena Hasan2, Serge Hercberg5, Olivier Lantz6, Hugo Mouquet2, Etienne Patin2, Sandra Pellegrini2, Stanislas Pol7, Antonio Rausell8, Lars Rogge2, Anavaj Sakuntabhai2, Olivier Schwartz2, Benno Schwikowski2, Spencer Shorte2, Frédéric Tangy2, Antoine Toubert9, Mathilde Touvier10, Marie-Noëlle Ungeheuer2, Matthew L. Albert11*, Darragh Duffy2*, Lluis Quintana-Murci2* 1INSERM U1163, University of Paris, Imagine Institute, Paris, France. 2Pasteur Institute, Paris, France. 3Lund University, Lund, Sweden. 4EPFL, Lausanne, Switzerland. 5Université Paris 13, Paris, France. 6Curie Institute, Paris, France. 7Cochin Hospital, Paris, France. 8INSERM UMR 1163 – Institut Imagine. 9Hôpital Saint-Louis, Paris, France. 10Université Paris 13, Paris, France. 11In Sitro. *Co-coordinators of the Milieu Intérieur Consortium. Additional information can be found at: https://www.pasteur.fr/labex/milieu-interieur., CoV-Contact Cohort Loubna Alavoine1, Karine K. A. Amat2, Sylvie Behillil3, Julia Bielicki4, Patricia Bruijning5, Charles Burdet6, Eric Caumes7, Charlotte Charpentier8, Bruno Coignard9, Yolande Costa1, Sandrine Couffin-Cardièrgues10, Florence Damond8, Aline Dechanet11, Christelle Delmas10, Diane Descamps8, Xavier Duval1, Jean-Luc Ecobichon1, Vincent Enouf3, Hélène Espérou10, Wahiba Frezouls1, Nadhira Houhou11, Emila Ilic-Habensus1, Ouifiya Kafif11, John Kikoine11, Quentin Le Hingrat8, David Lebeaux12, Anne Leclercq1, Jonathan Lehacaut1, Sophie Letrou1, Bruno Lina13, Jean-Christophe Lucet14, Denis Malvy15, Pauline Manchon11, Milica Mandic1, Mohamed Meghadecha16, Justina Motiejunaite17, Mariama Nouroudine1, Valentine Piquard11, Andreea Postolache11, Caroline Quintin1, Jade Rexach1, Layidé Roufai10, Zaven Terzian11, Michael Thy18, Sarah Tubiana1, Sylvie van der Werf3, Valérie Vignali1, Benoit Visseaux8, Yazdan Yazdanpanah14 1Centre d'Investigation Clinique, Inserm CIC 1425, Hôpital Bichat Claude Bernard, APHP, Paris, France. 2IMEA Fondation Léon M'Ba, Paris, France. 3Institut Pasteur, UMR 3569 CNRS, Université de Paris, Paris, France. 4University of Basel Children’s Hospital. 5Julius Center for Health Sciences and Primary Care, Utrecht. 6Université de Paris, IAME, Inserm UMR 1137, F-75018, Paris, France, Hôpital Bichat Claude Bernard, APHP, Paris, France. 7Hôpital Pitiè Salpétriere, APHP, Paris. 8Université de Paris, IAME, INSERM UMR 1137, AP-HP, University hospital Bichat Claude Bernard, Virology, F-75018 Paris, France. 9Santé Publique France, Saint Maurice, France. 10Pole Recherche Clinique, Inserm, Paris France. 11Hôpital Bichat Claude Bernard, APHP, Paris, France. 12APHP, Paris, France. 13Virpath Laboratory, International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France . 14IAME Inserm UMR 1138, Hôpital Bichat Claude Bernard, APHP, Paris, France. 15Service des Maladies Infectieuses et Tropicales; Groupe Pellegrin-Place Amélie-Raba-Léon, BORDEAUX. 16Hôpital Hotel Dieu, APHP, Paris, France. 17ervice des explorations fonctionnelles, Hôpital Bichat- Claude Bernard, APHP, Paris, France. 18Center for Clinical Investigation, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital., Amsterdam UMC Covid-19 Biobank Michiel van Agtmael1, Anne Geke Algera2, Frank van Baarle2, Diane Bax3, Martijn Beudel4, Harm Jan Bogaard5, Marije Bomers1, Lieuwe Bos2, Michela Botta2, Justin de Brabander6, Godelieve Bree6, Matthijs C. Brouwer4, Sanne de Bruin2, Marianna Bugiani7, Esther Bulle2, O. Chouchane1, Alex Cloherty3, Paul Elbers2, Lucas Fleuren2, Suzanne Geerlings1, Bart Geerts8, Theo Geijtenbeek9, Armand Girbes2, Bram Goorhuis1, Martin P. Grobusch1, Florianne Hafkamp9, Laura Hagens2, Jorg Hamann10, Vanessa Harris1, Robert Hemke11, Sabine M. Hermans1, Leo Heunks2, Markus Hollmann8, Janneke Horn2, Joppe W. Hovius1, Menno de Jong12, Rutger Koning4, Mourik van Mourik2, Jeaninne Nellen1, Frederique Paulus2, Edgar Peters1, Tom van der Poll1, Bennedikt Preckel8, Jan M. Prins1, Jorinde Raasveld2, Tom Reijnders1, Michiel Schinkel1, Marcus Schultz2, Alex Schuurman13, Kim Sigaloff1, Marry Smit2, Cornelis S. Stijnis1, Willemke Stilma2, Charlotte Teunissen14, Patrick Thoral2, Anissa Tsonas2, Marc van der Valk1, Denise Veelo8, Alexander P. J. Vlaar15, Heder de Vries2, Michèle van Vugt1, W. Joost Wiersinga1, Dorien Wouters16, A. H. (Koos) Zwinderman17, Diederik van de Beek18* 1Department of Infectious Diseases, Amsterdam UMC, Netherlands. 2Department of Intensive Care, Amsterdam UMC, Netherlands. 3Experimental Immunology, Amsterdam UMC, Netherlands. 4Department of Neurology, Amsterdam UMC, Netherlands. 5Department of Pulmonology, Amsterdam UMC, Netherlands. 6Department of Infectious Diseases, Amsterdam UMC, Netherlands. 7Department of Pathology, Amsterdam UMC, Netherlands. 8Department of Anesthesiology, Amsterdam UMC, Netherlands. 9Department of Experimental Immunology, Amsterdam UMC, Netherlands. 10Amsterdam UMC, THE NETHERLANDS Biobank Core Facility, Amsterdam UMC, Netherlands. 11Department of Radiology, Amsterdam UMC, Netherlands. 12Department of Medical Microbiology, Amsterdam UMC, Netherlands. 13Department of Internal Medicine, Amsterdam UMC, Netherlands. 14Neurochemical Laboratory, Amsterdam UMC, Netherlands. 15Deparment of Intensive Care, Amsterdam UMC, Netherlands. 16Department of Clinical Chemistry, Amsterdam UMC, Netherlands. 17Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC, Netherlands. 18Department of Neurology, Amsterdam UMC, Netherlands. *Leader of the AMC consortium., COVID Human Genetic Effort Laurent Abel1, Alessandro Aiuti2, Saleh Al Muhsen3, Fahd Al-Mulla4, Mark S. Anderson5, Andrés Augusto Arias6, Hagit Baris Feldman7, Dusan Bogunovic8, Alexandre Bolze9, Anastasiia Bondarenko10, Ahmed A. Bousfiha11, Petter Brodin12, Yenan Bryceson12, Carlos D. Bustamante13, Manish Butte14, Giorgio Casari15, Samya Chakravorty16, John Christodoulou17, Elizabeth Cirulli9, Antonio Condino Neto18, Megan A. Cooper19, Clifton L. Dalgard20, Joseph L. DeRisi21, Murkesh Desai22, Beth A. Drolet23, Sara Espinosa24, Jacques Fellay25, Carlos Flores26, Jose Luis Franco27, Peter K. Gregersen28, Filomeen Haerynck29, David Hagin30, Rabih Halwani31, Jim Heath32, Sarah E. Henrickson33, Elena Hsieh34, Kohsuke Imai35, Yuval Itan8, Timokratis Karamitros36, Kai Kisand37, Cheng-Lung Ku38, Yu-Lung Lau39, Yun Ling40, Carrie L. Lucas41, Tom Maniatis42, Davoud Mansouri43, Laszlo Marodi44, Isabelle Meyts45, Joshua Milner46, Kristina Mironska47, Trine Mogensen48, Tomohiro Morio49, Lisa P. Ng50, Luigi D. Notarangelo51, Giuseppe Novelli52, Antonio Novelli53, Cliona O'Farrelly54, Satoshi Okada55, Tayfun Ozcelik56, Rebeca Perez de Diego57, Anna M. Planas58, Carolina Prando59, Aurora Pujol60, Lluis Quintana-Murci61, Laurent Renia62, Alessandra Renieri63, Carlos Rodríguez-Gallego64, Vanessa Sancho-Shimizu65, Vijay Sankaran66, Kelly Schiabor Barrett9, Mohammed Shahrooei67, Andrew Snow68, Pere Soler-Palacín69, András N. Spaan70, Stuart Tangye71, Stuart Turvey72, Furkan Uddin73, Mohammed J. Uddin74, Diederik van de Beek75, Sara E. Vazquez76, Donald C. Vinh77, Horst von Bernuth78, Nicole Washington9, Pawel Zawadzki79, Helen C. Su51*, Jean-Laurent Casanova80* 1INSERM U1163, University of Paris, Imagine Institute, Paris, France. 2San Raffaele Telethon Institute for Gene Therapy, IRCCS Ospedale San Raffaele, Milan, Italy. 3King Saud University, Riyadh, Saudi Arabia. 4Kuwait University, Kuwait City, Kuwait. 5University of California, San Francisco, San Francisco, CA, USA. 6Universidad de Antioquia, Group of Primary Immunodeficiencies, Antioquia, Colombia. 7The Genetics Institute, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 8Icahn School of Medicine at Mount Sinai, New York, NY, USA. 9Helix, San Mateo, CA, USA. 10Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine. 11Clinical immunology unit, pediatric infectious disease departement, Faculty of Medicine and Pharmacy, Averroes University Hospital. LICIA Laboratoire d'immunologie clinique, d'inflammation et d'allergie, Hassann Ii University., Casablanca, Morocco. 12Karolinska Institute, Stockholm, Sweden. 13Stanford University, Stanford, CA, USA. 14University of California, Los Angeles, CA, USA. 15Medical Genetics, IRCCS Ospedale San Raffaele, Milan, Italy. 16Emory, Atlanta, GA, USA. 17Murdoch Children's Research Institute, Victoria, Australia. 18University of São Paulo, São Paulo, Brazil. 19Washington University School of Medicine, St. Louis, MO, USA. 20The American Genome Center; Uniformed Services University of the Health Sciences, Bethesda, MD, USA. 21University of California San Francisco; Chan Zuckerberg Biohub, San Francisco, CA, United States. 22Bai Jerbai Wadia Hospital for Children, Mumbai, India. 23 School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. 24Instituto Nacional de Pediatria (National Institute of Pediatrics), Mexico City, Mexico. 25Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland. 26Research Unit, Hospital Universitario Nuestra Señora de Candelaria, Canarian Health System, Santa Cruz de Tenerife, Spain. 27University of Antioquia, Medellín, Colombia. 28Feinstein Institute for Medical Research, Northwell Health USA, Manhasset, NY, USA. 29Department of Paediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID research lab, Jeffrey Modell Diagnosis and Research Centre, Ghent University Hospital, Edegem, Belgium. 30The Genetics Institute Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. 31Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE. 32Institute for Systems Biology, Seattle, WA, USA. 33Children's Hospital of Philadelphia, Philadelphia, PA, USA. 34Anschutz Medical Campus, Aurora, CO, USA. 35Riken, Tokyo, Japan. 36Hellenic Pasteur Institute, Athens, Greece. 37University of Tartu, Tartu, Estonia. 38Chang Gung University, Taoyuan County, Taiwan. 39The University of Hong Kong, Hong Kong, China. 40Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. 41Yale School of Medicine, New Haven, CT, USA. 42New York Genome Center, New York, NY, USA. 43Shahid Beheshti University of Medical Sciences, Tehran, Iran. 44Semmelweis University Budapest, Budapest, Hungary. 45KU Leuven, Department of Immunology, Microbiology and Transplantation, Leuven, Belgium. 46Columbia University Medical Center, New York, NY, USA. 47University Clinic for Children's Diseases, Skopje, North Macedonia. 48Aarhus University, Aarhus, Denmark. 49Tokyo Medical & Dental University Hospital, Tokyo, Japan. 50Singapore Immunology Network, Singapore. 51National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 52Bambino Gesù Children's Hospital, Rome, Italy; Dept. Biomedicine and Prevention, University of Rome “Tor Vergata”, Rome, Italy. 53Bambino Gesù Children's Hospital, Rome, Italy, Rome, Italy, Italy. 54Trinity College, Dublin, Ireland. 55Hiroshima University, Hiroshima, Japan. 56Bilkent University, Ankara, Turkey. 57Laboratory of Immunogenetics of Human Diseases, Innate Immunity Group, IdiPAZ Institute for Health Research, La Paz Hospital, Madrid 28046, Spain, EU, Madrid, Spain, Spain. 58IIBB-CSIC, IDIBAPS, Barcelona, Spain. 59Faculdades Pequeno Príncipe e Instituto de Pesquisa Pelé Pequeno Príncipe, Curitiba, Brazil. 60Neurometabolic Diseases Laboratory, IDIBELL- Hospital Duran I Reynals; Catalan Institution for Research and Advanced Studies (ICREA); CIBERER U759, ISCiii Madrid Spain, Barcelona, Spain. 61Institut Pasteur (CNRS UMR2000) and Collège de France, Paris, France. 62Infectious Diseases Horizontal Technology Center and Singapore Immunology Network, Agency for Science Technology (A*STAR), Singapore. 63University of Siena, Siena, Italy. 64Hospital Universitario de Gran Canaria Dr Negrín, Canarian Health System, Canary Islands, Spain. 65Imperial College London, London, UK. 66Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. 67Saeed Pathobiology and Genetic Lab, Tehran, Iran. 68Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA. 69Hospital Universitari Vall d'Hebron, Barcelona, Spain. 70University Medical Center Utrecht, Amsterdam, Netherlands. 71Garvan Institute of Medical Research, Sydney, Australia. 72The University of British Columbia, Vancouver, Canada. 73Holy Family Red Crescent Medical College; Centre for Precision Therapeutics, NeuroGen Children's Healthcare; Genetics and Genomic Medicine Centre, NeuroGen Children's Healthcare, Dhaka, Bangladesh. 74Mohammed Bin Rashid University of Medicine and Health Sciences, College of Medicine, Dubai, UAE; The Centre for Applied Genomics, Department of Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, Dhaka, Bangladesh. 75Amsterdam UMC, Amsterdam, Netherlands. 76University of California, San Francisco, San Francisco, CA, United States. 77McGill University Health Centre, Montreal, Canada. 78Charité - Berlin University Hospital Center, Berlin, Germany. 79Molecular Biophysics Division, Faculty of Physics, A. Mickiewicz University, Uniwersytetu Poznanskiego 2, Poznań, Poland. 80Rockefeller University, Howard Hughes Medical Institute, Necker Hospital, New York, NY, USA. *Leaders of the COVID Human Genetic Effort., Interindividual clinical variability in the course of SARS-CoV-2 infection is immense. We report that at least 101 of 987 patients with life-threatening COVID-19 pneumonia had neutralizing IgG auto-Abs against IFN-ω (13 patients), the 13 types of IFN-α (36), or both (52), at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1,227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 were men. A B cell auto-immune phenocopy of inborn errors of type I IFN immunity underlies life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men., The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the French National Research Agency (ANR) under the “Investments for the Future” program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62- IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project, ANRS-COV05, the Square Foundation, Grandir - Fonds de solidarité pour l’enfance, the SCOR Corporate Foundation for Science, Institut Institut National de la Santé et de la Recherche Médicale (INSERM) and the University of Paris. Samples from San Raffaele Hospital were obtained within the Covid-BioB project and healthcare personnel of San Raffaele Hospital, San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) clinical lab and clinical research Unit; funded by the Program Project COVID-19 OSR-UniSR and Fondazione Telethon. The French COVID Cohort study group was sponsored by Inserm and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). The Cov-Contact Cohort was supported by the REACTing consortium, the French Ministry of Health, and the European Commission (RECOVER WP 6). The “Milieu Intérieur” cohort was supported by was supported by the French Government’s Investissement d’Avenir Program, Laboratoire d’Excellence “Milieu Intérieur” Grant (ANR-10-LABX-69-01) (PI: L QuintanaMurci & D Duffy). The Simoa experiment was supported by the PHRC-20-0375 COVID-19 grant “DIGITAL COVID” (PI: G Gorochov). SGT is supported by a Leadership 3 Investigator Grant awarded by the National Health and Medical Research Council of Australia, and a COVID19 Rapid Response Grant awarded by UNSW Sydney. CRG and colleagues were supported by Instituto de Salud Carlos III (COV20_01333 and COV20_01334, Spanish Ministry of Science and Innovation -RTC-2017-6471-1; AEI/FEDER, UE), and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”). SA and AB were supported by ANR-20-COVI-0064 (PI: A Belot). This work is supported by the French Ministry of Health “Programme Hospitalier de Recherche Clinique Inter regional 2013”, by the Contrat de Plan Etat-Lorraine and FEDER Lorraine, and a public grant overseen by the French National Research Agency (ANR) as part of the second “Investissements d’Avenir” program FIGHT-HF (reference: ANR-15-RHU-0004) and by the French PIA project “Lorraine Université d’Excellence”, reference ANR15-IDEX-04-LUE (45) and biobanking is performed by the Biological Resource Center Lorrain BB-0033-00035. This study was supported by the Fonds IMMUNOV, for Innovation in Immunopathology and by a grant from the Agence National de la Recherche (ANR-flash Covid19 “AIROCovid” to FRL), and by the FAST Foundation (French Friends of Sheba Tel Hashomer Hospital). Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1, a George Mason University Fast Grant, and the G. Harold and Leila Y. Mathers Charitable Foundation. The Amsterdam UMC Covid-19 Biobank was supported by grants of the Amsterdam Corona Research Fund, Dr. C.J. Vaillant Fund, and Netherlands Organization for Health Research and Development (ZonMw; NWO-Vici-Grant [grant number 918·19·627 to DvdB]. This work was also supported by the Division of Intramural Research of the National Institute of Dental Craniofacial Research and National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by Regione Lombardia, Italy (project “Risposta immune in pazienti con COVID-19 e comorbidita”). The opinions and assertions expressed herein are those of the author(s) and do not necessarily reflect the official policy or position of the Uniformed Services University or the Department of Defense. JH holds an Institut Imagine MD-PhD fellowship from the Fondation Bettencourt Schueller. JR is supported by the Inserm PhD program (“poste d’accueil Inserm”). PB was supported by the French Foundation for Medical Research (FRM, EA20170638020) and the MD-PhD program of the Imagine Institute (with the support of the Fondation Bettencourt-Schueller). We thank the Association “Turner et vous” for their help and support. Sample processing at IrsiCaixa was possible thanks to the crowdfunding initiative YoMeCorono. DCV is supported by the Fonds de la recherche en santé du Québec clinician-scientist scholar program. K. Kisand was supported by the Estonian Research Council grant PUT1367. We thank the GEN-COVID Multicenter Study (https://sites.google.com/dbm.unisi.it/gen-covid). We thank the NIAID Office of Cyber Infrastructure and Computational Biology, Bioinformatics and Computational Biosciences Branch (Contract HHSN316201300006W/HHSN27200002 to MSC, Inc) and Operations Engineering Branch for developing the HGRepo system to enable streamlined access to the data and the NCI Advanced Biomedical Computational Science (ABCS) for data transformation support.
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- 2020
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21. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study
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Valeria Bellisario, Anne-Elie Carsin, Cecilie Svanes, Chantal Raherison, Bénédicte Leynaert, Elaine Fuertes, Stefano Guerra, José Luis Sánchez Ramos, Emmanuel Schaffner, Joachim Heinrich, Thorarinn Gislason, Nicole Probst-Hensch, Christer Janson, Medea Imboden, Isabelle Pin, Josep M. Antó, Pascal Demoly, Jesús Martínez-Moratalla, Kjell Torén, José Antonio Gullón, Isa Cerveri, Francisco Gómez Real, Bertil Forsberg, Joost Weyler, Anna Beckmeyer-Borowko, Silvia Pascual, Dirk Keidel, Rain Jõgi, Dennis Nowak, Margareta Emtner, Seraina Caviezel, Simone Accordini, Wasif Raza, Judith Garcia-Aymerich, Shyamali C. Dharmage, Deborah Jarvis, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, University Hospital Basel [Basel], Imperial College London, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Helmholtz Zentrum München = German Research Center for Environmental Health, German Centre for Lung Research, Partenaires INRAE, School of Medicine [University of Melbourne], University of Melbourne, Haukeland University Hospital, University of Bergen (UiB), Universiteit Antwerpen = University of Antwerpen [Antwerpen], Ludwig Maximilian University [Munich] (LMU), Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM), Respiratory Department, Hospital Universitario San Agustín (HUSA), Universidad de Huelva, Swiss Tropical and Public Health Institute [Basel], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Sorbonne Université (SU), IRCCS 'San Matteo' Hospital Foundation [Pavie, Italie], Università degli Studi di Pavia = University of Pavia (UNIPV), University Hospital of Verona, Landspitali National University Hospital of Iceland, Göteborgs Universitet (GU), Uppsala University Hospital, University of Tartu, Umeå University, Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Galdakao Hospital, University of Arizona, Melbourne School of Population and Global Health [Melbourne], Universitat Pompeu Fabra [Barcelona] (UPF), Salvy-Córdoba, Nathalie, Helmholtz-Zentrum München (HZM), University of Turin, Universiteit Antwerpen [Antwerpen], Universidad de Castilla-La Mancha (UCLM), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), University of Pavia, Department of Pulmonary Medicine, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Medical Research Council (MRC), and Commission of the European Communities
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Male ,DISORDER ,Cardiac & Cardiovascular Systems ,Cross-sectional study ,Epidemiology ,Vital Capacity ,Respiratory System ,ACTIVITY QUESTIONNAIRE ,Disease ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,DISEASE ,0302 clinical medicine ,Forced Expiratory Volume ,Prevalence ,Prospective Studies ,030212 general & internal medicine ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,Prospective cohort study ,Lung ,Body mass index ,RISK ,medicine.diagnostic_test ,Middle Aged ,IMPAIRMENT ,Respiratory Function Tests ,3. Good health ,Europe ,LUNG-FUNCTION ,medicine.anatomical_structure ,Lung function ,Physical activity ,Restrictive spirometry pattern ,Female ,Life Sciences & Biomedicine ,[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology ,MESH: Exercise / physiology ,Lung / physiopathology ,Lung Diseases, Obstructive / physiopathology ,Obesity / epidemiology ,Spirometry / adverse effects ,NATIONAL-HEALTH ,Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,Restrictive Spirometry Pattern ,Body Mass Index ,Lung Function ,Physical Activity ,1102 Cardiovascular Medicine And Haematology ,EVENTS ,03 medical and health sciences ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Internal medicine ,medicine ,Humans ,Lung Diseases, Obstructive ,Obesity ,Exercise ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Science & Technology ,business.industry ,MORTALITY ,1103 Clinical Sciences ,medicine.disease ,Cross-Sectional Studies ,030228 respiratory system ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Cardiovascular System & Cardiology ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Human medicine ,business - Abstract
Introduction: Restrictive spirometry pattern is an under-recognised disorder with a poor morbidity and mortality prognosis. We compared physical activity levels between adults with a restrictive spirometry pattern and with normal spirometry. Methods: Restrictive spirometry pattern was defined as a having post-bronchodilator FEV1/FVC ≥ Lower Limit of Normal and a FVC
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- 2019
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22. Pharmacological treatment of asthma in a cohort of adults during a 20-year period : results from the European Community Respiratory Health Survey I, II and III
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Christer Janson, Simone Accordini, Lucia Cazzoletti, Isa Cerveri, Sebastien Chanoine, Angelo Corsico, Diogenes Seraphim Ferreira, Judith Garcia-Aymerich, David Gislason, Rune Nielsen, Ane Johannessen, Rain Jogi, Andrei Malinovschi, Jesús Martinez-Moratalla Rovira, Alessandro Marcon, Isabelle Pin, Jennifer Quint, Valerie Siroux, Enrique Almar, Valeria Bellisario, Karl A. Franklin, José A. Gullón, Mathias Holm, Joachim Heinrich, Dennis Nowak, José Luis Sánchez-Ramos, Joost J. Weyler, Deborah Jarvis, The members of the ECRHS I scientific team., P. Burney, S. Chinn, C. Luczynska, D. Jarvis, E. Lai, P. Vermeire, H. Kesteloot, J. Bousquet, D. Nowak, J. Prichard, R. de Marco, B. Rijcken, J.M. Anto, J. Sunyer, J. Alves, G. Boman, N. Nielsen, P. Paoletti, M. Abramson, J. Kutin, F. van Bastelaer, R. Jõgi, A. Taytard, I. Pin, C. Pison, F. Neukirch, R. Liard, J. Knani, H-E. Wichmann, J. Heinrich, H. Magnussen, T. Gislason, D. Gislason, A. Marinoni, I. Cerveri, M. Bugiani, C. Bucca, C. Romano, L. Cascio, C. Campello, J. Droste, M. Kerkhof, A. Gulsvik, E. Omenaas, J. Martinez-Moratalla, E. Almar, A. Mateos, M. Arévalo, A. Sánchez, M. Vizcaya, X. Aguilar, A. Teixidó, J.M. Antó, M. Kogevinas, F. Burgos, J. Castellsagué, J. Roca, JB. Soriano, A. Tobías, N. Muiñozguren, J. Ramos González, A. Capelastegui, J. Maldonado Pérez, A. Pereira, J. Sánchez, J. Quiros, I. Huerta, F. Payo, N. Lindholm, P. Plaschke, C. Janson, E. Björnsson, L. Rosenhall, E. Norrman, B. Lundbäck, U. Ackermann-Liebrich, N. Küenzli, A. Perruchoud, M. Burr, J. Layzell, R. Hall, B. Harrison, The members of the ECRHS II scientific team., J. Knox, M. Wjst, N. Kuenzli, E.H. Walters, J. Raven, J. Weyler, M. van Sprundel, V. Nelen, A. Soon, C. Raherison, J. Ferran-Quentin, B. Leynaert, M. Zureik, P.J. Bousquet, C. Frye, I. Meyer, E. Bjornsson, K.B. Jörundsdóttir, S. Villani, M. Ponzio, F. Frigerio, M. Comelli, M. Grassi, A. Corsico, R. Bono, P. Piccioni, E. Caria, A. Carosso, E. Migliore, G. Castiglioni, G. Verlato, E. Zanolin, S. Accordini, A. Poli, V. Lo Cascio, M. Ferrari, I. Cazzoletti, C. Svanes, B. Laerum, J. Martinez-Moratalla Rovira, C. Boix, G. González, J.M. Ignacio García, J. Solera, J. Damián, J.P. Zock, X. Basagaña, A. Jaen, C. Acosta, N. Muñozguren, J. Ramos, I. Urrutia, U. Aguirre, J. Maldonado, J.L. Sanchez, A. de la Vega, L. Palenciano, J. Azofra, A. Cañada, K. Toren, L. Lillienberg, A.C. Olin, B. Balder, A. Pfeifer-Nilsson, R. Sundberg, D. Norback, G. Wieslander, M. Gunnbjornsdottir, M. Soderberg, K.A. Franklin, B. Lundback, B. Forsberg, L. Nystrom, B. Dibbert, M. Hazenkamp, M. Brutsche, D. Seaton, The members of the ECRHS III scientific team., M. Tumilty, J. Potts, T. Gislasson, T. Rochat, B. Leyneart, G. Benke, S. Dharmage, B. Thompson, S. Kaushik, M. Matheson, H. Bentouhami, H. Orru, P.O. Girodet, V. Siroux, J. Ferran, J.L. Cracowski, P. Demoly, A. Bourdin, I. Vachier, D. Soussan, D. Courbon, C. Neukirch, L. Alavoine, X. Duval, I. Poirier, E. Becker, G. Woelke, O. Manuwald, A-M. Kirsten, B. Benediktsdottir, E.S. Arnardottir, M. Clausen, G. Gudmundsson, L. Gudmundsdottir, H. Palsdottir, K. Olafsdottir, S. Sigmundsdottir, K. Bara-Jörundsdottir, A. Grosso, F. Albicini, E. Gini, E.M. Di Vincenzo, V. Ronzoni, F. Campanella, M. Gnesi, F. Manzoni, L. Rossi, O. Ferraro, R. Tassinari, V. Bellisario, G. Trucco, L. Calciano, L. Cazzoletti, A.M. Fratta Pasini, F. Locatelli, P. Marchetti, A. Marcon, E. Montoli, G. Nguyen, M. Olivieri, C. Papadopoulou, C. Posenato, G. Pesce, P. Vallerio, H.M. Boezen, A. Johannessen, T. Skorge, F. Gomez Real, S. García, A. Núñez, P. López, R. Sánchez, E. Mancebo, J-M. Antó, J. Garcia-Aymerich, A.E. Carsin, C. Sanjuas, S. Guerra, B. Jacquemin, P. Davdand Galdakao, S. Pascual, J. Antonio Maldonado, J.L. Sánchez, L. Palacios, N. Sánchez, M. Fernández, B. Robles, K. Torén, M. Holm, J-L. Kim, A-C. Olin, A. Dahlman-Höglund, L. Braback, L. Modig, B. Järvholm, K.A. Bertilsson, H. Franklin, C. Wahlgreen, B. Andersson, U. Spetz Nystrom, G.M. Bodinaa Lund, K. Nisser, N.M. Probst-Hensch, N. Künzli, D. Stolz, C. Schindler, J.M. Gaspoz, E. Zemp Stutz, M. Adam, C. Autenrieth, I. Curjuric, J. Dratva, A. Di Pasquale, R. Ducret-Stich, E. Fischer, L. Grize, A. Hensel, D. Keidel, A. Kumar, M. Imboden, N. Maire, A. Mehta, H. Phuleria, M. Ragettli, M. Ritter, E. Schaffner, G.A. Thun, A. Ineichen, T. Schikowski, M. Tarantino, M. Tsai, S. Kapur, R. Newson, N. Innes, A. Wilson, Uppsala University, National Heart and Lung Institute [London] (NHLI), Royal Brompton and Harefield NHS Foundation Trust-Imperial College London, University of Verona (UNIVR), University of Pavia, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Monash University [Melbourne], Universidade Federal do Parana [Curitiba] (UFPR), Universidade Federal do Paraná (UFPR), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Landspitali National University Hospital of Iceland, Haukeland University Hospital, University of Bergen (UiB), Tartu University Hospital [Tartu, Estonia], Complejo Hospitalario Universitario de Albacete, University of Castilla-La Mancha (UCLM), Service de chirurgie pédiatrique [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Université Grenoble Alpes (UGA), Service of the Health Delegation of Albacete [Albacete, Spain], University of Turin, Umeå University, Universidad Nacional de San Agustín (UNSA), University of Gothenburg (GU), Ludwig Maximilian University [Munich] (LMU), Helmholtz-Zentrum München (HZM), Melbourne School of Population and Global Health [Melbourne], University of Melbourne, German Center for Lung Research - DZL [Munich, Germany], Universidad de Huelva, University of Antwerp (UA), Medical Research Council (MRC), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Università degli studi di Verona = University of Verona (UNIVR), Università degli Studi di Pavia = University of Pavia (UNIPV), Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM), Università degli studi di Torino = University of Turin (UNITO), Helmholtz Zentrum München = German Research Center for Environmental Health, and Siroux, Valérie
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Pulmonary and Respiratory Medicine ,Pediatrics ,medicine.medical_specialty ,European community ,Period (gene) ,Respiratory Medicine and Allergy ,MEDLINE ,lcsh:Medicine ,ECRHS ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Pharmacological treatment ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,Respiratory health ,Asthma ,Lungmedicin och allergi ,Asthma, treatment, ECRHS ,treatment ,business.industry ,lcsh:R ,Original Articles ,medicine.disease ,3. Good health ,030228 respiratory system ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Cohort ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with the regular use of inhaled corticosteroid (ICS) treatment. Changes in the use of medication were determined in 4617 randomly selected subjects, while changes in adults with persistent asthma were analysed in 369 participants. The study compares data from three surveys in 24 centres in 11 countries. The use of ICSs increased from 1.7% to 5.9% in the general population and the regular use of ICSs increased from 19% to 34% among persistent asthmatic subjects. The proportion of asthmatic subjects reporting asthma attacks in the last 12 months decreased, while the proportion that had seen a doctor in the last 12 months remained unchanged (42%). Subjects with asthma who had experienced attacks or had seen a doctor were more likely to use ICSs on a regular basis. Although ICS use has increased, only one-third of subjects with persistent asthma take ICSs on a regular basis. Less than half had seen a doctor during the last year. This indicates that underuse of ICSs and lack of regular healthcare contacts remains a problem in the management of asthma., Despite increased ICS use, only 34% of subjects with persistent asthma take ICSs on a regular basis
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- 2019
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23. Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
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Ezzati, M. and Zhou, B. and Bentham, J. and Di Cesare, M. and Bixby, H. and Danaei, G. and Hajifathalian, K. and Taddei, C. and Carrillo-Larco, R.M. and Djalalinia, S. and Khatibzadeh, S. and Lugero, C. and Peykari, N. and Zhang, W.Z. and Bennett, J. and Bilano, V. and Stevens, G.A. and Cowan, M.J. and Riley, L.M. and Chen, Z. and Hambleton, I.R. and Jackson, R.T. and Kengne, A.P. and Khang, Y.-H. and Laxmaiah, A. and Liu, J. and Malekzadeh, R. and Neuhauser, H.K. and Sorić, M. and Starc, G. and Sundström, J. and Woodward, M. and Abarca-Gómez, L. and Abdeen, Z.A. and Abu-Rmeileh, N.M. and Acosta-Cazares, B. and Adams, R.J. and Aekplakorn, W. and Afsana, K. and Aguilar-Salinas, C.A. and Agyemang, C. and Ahmad, N.A. and Ahmadvand, A. and Ahrens, W. and Ajlouni, K. and Akhtaeva, N. and Al-Raddadi, R. and Ali, M.M. and Ali, O. and Alkerwi, A. and Aly, E. and Amarapurkar, D.N. and Amouyel, P. and Amuzu, A. and Andersen, L.B. and Anderssen, S.A. and Ängquist, L.H. and Anjana, R.M. and Ansong, D. and Aounallah-Skhiri, H. and Araújo, J. and Ariansen, I. and Aris, T. and Arlappa, N. and Arveiler, D. and Aryal, K.K. and Aspelund, T. and Assah, F.K. and Assunção, M.C.F. and Avdicová, M. and Azevedo, A. and Azizi, F. and Babu, B.V. and Bahijri, S. and Balakrishna, N. and Bamoshmoosh, M. and Banach, M. and Bandosz, P. and Banegas, J.R. and Barbagallo, C.M. and Barceló, A. and Barkat, A. and Barros, A.J.D. and Barros, M.V. and Bata, I. and Batieha, A.M. and Batyrbek, A. and Baur, L.A. and Beaglehole, R. and Romdhane, H.B. and Benet, M. and Benson, L.S. and Bernabe-Ortiz, A. and Bernotiene, G. and Bettiol, H. and Bhagyalaxmi, A. and Bharadwaj, S. and Bhargava, S.K. and Bi, Y. and Bikbov, M. and Bista, B. and Bjerregaard, P. and Bjertness, E. and Bjertness, M.B. and Björkelund, C. and Blokstra, A. and Bo, S. and Bobak, M. and Boeing, H. and Boggia, J.G. and Boissonnet, C.P. and Bongard, V. and Borchini, R. and Bovet, P. and Braeckman, L. and Brajkovich, I. and Branca, F. and Breckenkamp, J. and Brenner, H. and Brewster, L.M. and Bruno, G. and Bueno-de-Mesquita, H.B. and Bugge, A. and Burns, C. and Bursztyn, M. and de León, A.C. and Cacciottolo, J. and Cai, H. and Cameron, C. and Can, G. and Cândido, A.P.C. and Capuano, V. and Cardoso, V.C. and Carlsson, A.C. and Carvalho, M.J. and Casanueva, F.F. and Casas, J.-P. and Caserta, C.A. and Chamukuttan, S. and Chan, A.W. and Chan, Q. and Chaturvedi, H.K. and Chaturvedi, N. and Chen, C.-J. and Chen, F. and Chen, H. and Chen, S. and Cheng, C.-Y. and Dekkaki, I.C. and Chetrit, A. and Chiolero, A. and Chiou, S.-T. and Chirita-Emandi, A. and Chirlaque, M.-D. and Cho, B. and Cho, Y. and Christofaro, D.G. and Chudek, J. and Cifkova, R. and Cinteza, E. and Claessens, F. and Clays, E. and Concin, H. and Cooper, C. and Cooper, R. and Coppinger, T.C. and Costanzo, S. and Cottel, D. and Cowell, C. and Craig, C.L. and Crujeiras, A.B. and Cruz, J.J. and D'Arrigo, G. and d'Orsi, E. and Dallongeville, J. and Damasceno, A. and Dankner, R. and Dantoft, T.M. and Dauchet, L. and Davletov, K. and De Backer, G. and De Bacquer, D. and de Gaetano, G. and De Henauw, S. and de Oliveira, P.D. and De Smedt, D. and Deepa, M. and Dehghan, A. and Delisle, H. and Deschamps, V. and Dhana, K. and Di Castelnuovo, A.F. and Dias-da-Costa, J.S. and Diaz, A. and Dickerson, T.T. and Do, H.T.P. and Dobson, A.J. and Donfrancesco, C. and Donoso, S.P. and Döring, A. and Dorobantu, M. and Doua, K. and Drygas, W. and Dulskiene, V. and Džakula, A. and Dzerve, V. and Dziankowska-Zaborszczyk, E. and Eggertsen, R. and Ekelund, U. and El Ati, J. and Elliott, P. and Elosua, R. and Erasmus, R.T. and Erem, C. and Eriksen, L. and Eriksson, J.G. and Escobedo-de la Peña, J. and Evans, A. and Faeh, D. and Fall, C.H. and Farzadfar, F. and Felix-Redondo, F.J. and Ferguson, T.S. and Fernandes, R.A. and Fernández-Bergés, D. and Ferrante, D. and Ferrari, M. and Ferreccio, C. and Ferrieres, J. and Finn, J.D. and Fischer, K. and Föger, B. and Foo, L.H. 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Latvia, Latvia, National Institute of Nutrition and Food Technology, Tunisia, Institut Hospital del Mar d'Investigacions Mèdiques, Spain, University of Stellenbosch, South Africa, Karadeniz Technical University, Turkey, National Institute for Health and Welfare, Finland, Queen's University of Belfast, United Kingdom, University of Zurich, Switzerland, Centro de Salud Villanueva Norte, Spain, The University of the West Indies, Jamaica, Hospital Don Benito-Villanueva de la Serena, Spain, Ministry of Health, Argentina, Council for Agricultural Research and Economics, Italy, Pontificia Universidad Católica de Chile, Chile, University of Manchester, United Kingdom, University of Tartu, Estonia, Universiti Sains Malaysia, Malaysia, Umeå University, Sweden, Dalarna University, Sweden, Federal University of São Paulo, Brazil, Hospital Universitario Son Espases, Spain, Hospital de Clinicas de Porto Alegre, Brazil, Universidade Federal do Rio Grande do Sul, Brazil, Kindai University, Japan, Kyoto University, Japan, Medical University of Warsaw, Poland, University of Catania, Italy, CIBER en Epidemiología y Salud Pública, Spain, University of KwaZulu-Natal, South Africa, Geneva University Hospitals, Switzerland, Australian Bureau of Statistics, Australia, Wageningen University, Netherlands, B P Koirala Institute of Health Sciences, Nepal, University of Insubria, Italy, Ministry of Health, Israel, The Andes Clinic of Cardio-Metabolic Studies, Venezuela, National Institute of Hygiene, Epidemiology and Microbiology, Cuba, Université de Lille 2, France, Institute for Clinical and Experimental Medicine, Czech Republic, Children'sMemorial Health Institute, Poland, Alexander Technological Educational Institute, Greece, Jagiellonian University Medical College, Poland, Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele, Italy, University of Novi Sad, Serbia, National Center of Cardiovascular Diseases, China, Singapore Eye Research Institute, Singapore, Icelandic Heart Association, Iceland, Universidad Icesi, Colombia, King's College London, United Kingdom, International Agency for Research on Cancer, France, Healis-Sekhsaria Institute for Public Health, India, Eternal Heart Care Centre and Research Institute, India, University of Ibadan, Nigeria, Children's Memorial Health Institute, Poland, Institute for Clinical Effectiveness and Health Policy, Argentina, Danish Cancer Society Research Centre, Denmark, Kyushu University, Japan, Tulane University, United States, Chinese Center for Disease Control and Prevention, China, Academic Medical Center of University of Amsterdam, Netherlands, National Institute of Public Health, Mexico, Oulu University Hospital, Finland, Chronic Diseases Research Center, Iran, University of Hong Kong, Hong Kong, The Chinese University of Hong Kong, Hong Kong, University of Western Australia, Australia, Celal Bayar University, Turkey, Heart Institute, Brazil, Fundación Oftalmológica de Santander, Colombia, University of Oran 1, Algeria, Independent Public Health Specialist, Myanmar, Ministry of Health, Myanmar, Peking University, China, VU University Medical Center and VU University, Netherlands, American University of Beirut, Lebanon, Cairo University, Egypt, National Institute of Health and Nutrition, Japan, Aga Khan University, Pakistan, UHC Zagreb, Croatia, Niigata University, Japan, Hadassah University Medical Center, Israel, Duke- NUS Medical School, Singapore, Norwegian University of Science and Technology, Norway, University of Zagreb School of Medicine, Croatia, Heart Foundation, Australia, National Health Insurance Service, South Korea, Guangzhou 12th Hospital, China, Simon Fraser University, Canada, Ruprecht-Karls- University of Heidelberg, Germany, Research Centre for Prevention and Health, Denmark, World Health Organization Country Office, India, Czestochowa University of Technology, Poland, University of Crete, Greece, Universiti Kebangsaan Malaysia, Malaysia, Johns Hopkins Bloomberg School of Public Health, United States, University of Eastern Finland, Finland, National Institute of Epidemiology, India, University of Münster, Germany, Israel Center for Disease Control, Israel, Research Institute for Primordial Prevention of Noncommunicable Disease, Iran, VU University Medical Center, Netherlands, Kyrgyz State Medical Academy, Kyrgyzstan, Research Institute of Child Nutrition, Germany, University of Cambridge, United Kingdom, Medical University of Innsbruck, Austria, Muhimbili University of Health and Allied Sciences, Tanzania, National Cancer Center, South Korea, Institute of Tropical Medicine, Belgium, Tartu University Clinics, Estonia, Ministry of Health and Quality of Life, Mauritius, Polish Academy of Sciences Anthropology Unit in Wroclaw, Poland, University of Zürich, Switzerland, University of Groningen, Netherlands, North-West University, South Africa, National Institute of Public Health, Czech Republic, University of Jyväskylä, Finland, Amrita Institute of Medical Sciences, India, All India Institute of Medical Sciences, India, African Population and Health Research Center, Kenya, Ministerio de Salud Pública, Cuba, Sahlgrenska Academy, Sweden, Endocrinology and Metabolism Research Center, Iran, Food and Agriculture Organization of the United Nations, Italy, National University of Singapore, Singapore, Tampere University Hospital, Finland, University of Cape Town, South Africa, West Virginia University, United States, Oswaldo Cruz Foundation Rene Rachou Research Institute, Brazil, National Taiwan University, Taiwan, University of Chinese Academy of Sciences, China, University Medicine Greifswald, Germany, Consejería de Sanidad Junta de Castilla y León, Spain, University of Uppsala, Sweden, Universidade Federal de Ouro Preto, Brazil, The Jikei University School of Medicine, Japan, National Research Council, Italy, Baker Heart and Diabetes Institute, Australia, Agricultural University of Athens, Greece, Hospital Israelita Albert Einstein, Brazil, Shiraz University of Medical Sciences, Iran, Institute of Internal and Preventive Medicine, Russian Federation, Harokopio University, Greece, University of Otago, New Zealand, University of Padova, Italy, Lausanne University Hospital, Switzerland, CIBERCV, Spain, Emory University, United States, UiT The Arctic University of Norway, Norway, Cape Peninsula University of Technology, South Africa, Gorgas Memorial Institute of Health Studies, Panama, Brown University, United States, University of Edinburgh, United Kingdom, Statistics Canada, Canada, University College Dublin, Ireland, Institut National de la Santé et de la Recherche Médicale, France, Lusófona University, Portugal, Universita' degli Studi di Firenze, Italy, Ain Shams University, Egypt, Hypertension Research Center, Iran, University of Pécs, Hungary, Seoul National University Children's Hospital, South Korea, University Medical Science, Cuba, Universidad de Zaragoza, Spain, RCSI Dublin, Ireland, La Trobe University, Australia, International Institute of Molecular and Cell Biology, Poland, Ahvaz Jundishapur University of Medical Sciences, Iran, Gorgas Memorial Institute of Public Health, Panama, World Health Organization Country Office, Malawi, Department of Public Health, Myanmar, University of Brescia, Italy, Bushehr University of Medical Sciences, Iran, Ulm University, Germany, Kobe University, Japan, Suraj Eye Institute, India, University Medicine of Greifswald, Germany, INSERM, France, National Institute of Hygiene and Epidemiology, Viet Nam, The University of Pharmacy and Medicine of Ho Chi Minh City, Viet Nam, Hanoi Medical University, Viet Nam, National Hospital of Endocrinology, Viet Nam, Miami Veterans Affairs Healthcare System, United States, University of Turku Tyks, Finland, Heartfile, Pakistan, Eastern Mediterranean Public Health Network, Jordan, Tachikawa General Hospital, Japan, Academic Hospital of Paramaribo, Suriname, Ministry of Health, Brunei Darussalam, University of Madeira, Portugal, MRC Lifecourse Epidemiology Unit, United Kingdom, Aarhus University, Denmark, Kwame Nkrumah University of Science and Technology, Ghana, Institute for Social and Preventive Medicine, Switzerland, University of Coimbra, Portugal, Cancer Prevention and Research Institute, Italy, Ruprecht-Karls-University of Heidelberg, Germany, IRCCS Casa Sollievo della Sofferenza, Italy, Zayed University, United Arab Emirates, Catholic University of Daegu, South Korea, Jivandeep Hospital, India, University Hospital Centre Zagreb, Croatia, University Medical Center Utrecht, Netherlands, Vietnam National Heart Institute, Viet Nam, University of Sarajevo, Bosnia and Herzegovina, Cardiovascular Prevention Centre Udine, Italy, Ministry of Health and Medical Services, Solomon Islands, Public Health Agency of Catalonia, Spain, University of Split, Croatia, Digestive Oncology Research Center, Iran, Digestive Disease Research Institute, Iran, Alborz University of Medical Sciences, Iran, Ministry of Health, Viet Nam, University of Turku, Finland, Universiti Putra Malaysia, Malaysia, University of Malaya, Malaysia, University of Valencia, Spain, University of the Philippines, Philippines, Minas Gerais State Secretariat for Health, Brazil, Health Center San Agustín, Spain, PharmAccess Foundation, Netherlands, Universidade Nove de Julho, Brazil, Public Health Agency of Canada, Canada, Canarian Health Service, Spain, Universidad Industrial de Santander, Colombia, Instituto Nacional de Salud Pública, Mexico, Sitaram Bhartia Institute of Science and Research, India, Marmara University, Turkey, CIBER de Epidemiología y Salud Pública, Spain, University of Helsinki, Finland, National Institute of Health, Peru, Catalan Department of Health, Spain, Universidade de Lisboa, Portugal, University of Sao Paulo Clinics Hospital, Brazil, South Karelia Social and Health Care District, Finland, Isfahan Cardiovascular Research Center, Iran, Research and Education Institute of Child Health, Cyprus, Hospital Italiano de Buenos Aires, Argentina, Lagos State University College of Medicine, Nigeria, The University of Tokyo, Japan, Samsung Medical Center, South Korea, Federal University of Santa Catarina, Brazil, St Vincent's Hospital, Australia, Academic Medical Center Amsterdam, Netherlands, University of Bari, Italy, Lund University, Sweden, University of Copenhagen, Denmark, Institut Régional de Santé Publique, Benin, University of Bordeaux, France, University of Leuven, Belgium, Bonn University, Germany, Sotiria Hospital, Greece, National Institute of Public Health- National Institute of Hygiene, Poland, Fu Jen Catholic University, Taiwan, Ministry of Health, Jordan, Health Service of Murcia, Spain, IB-SALUT Area de Salut de Menorca, Spain, Institut de Recherche pour le Développement, France, Hellenic Health Foundation, Greece, GovernmentMedical College, India, Sefako Makgatho Health Science University, South Africa, Addis Ababa University, Ethiopia, Dasman Diabetes Institute, Kuwait, Ministry of Health, New Zealand, Universidad Centro-Occidental Lisandro Alvarado, Venezuela, University of Tampere Tays Eye Center, Finland, Utrecht University, Netherlands, Hanoi University of Public Health, Viet Nam, Amsterdam Public Health Research Institute, Netherlands, Universidade Federal de Minas Gerais, Brazil, Finnish Institute of Occupational Health, Finland, Universidad Miguel Hernandez, Spain, North Karelian Center for Public Health, Finland, University of the Witwatersrand, South Africa, University of Strasbourg, France, Institute for Medical Research, Malaysia, Xinjiang Medical University, China, Capital Medical University, China, St George's, University of London, United Kingdom, Medical University of Vienna, Austria, Universitas Indonesia, Indonesia, National Institute of Public Health-National Institute of Hygiene, Poland, Institute of Food and Nutrition Development of Ministry of Agriculture, China, Children's Hospital of Fudan University, China, University of Cyprus, Cyprus, Universiti Teknologi MARA, Malaysia, Inner Mongolia Medical University, China, Universidad Politécnica de Madrid, Spain, State University of Montes Claros, Brazil, and University of Limpopo, South Africa
- Subjects
sense organs - Abstract
Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups. © The Author(s) 2018.
- Published
- 2018
24. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
- Author
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and Cisneros, J.Z. and Zhu, D. and Eggertsen, R. and NCD Risk Factor Collaboration (NCD-RisC), Imperial College London, United Kingdom, Middlesex University, United Kingdom, World Health Organization, Switzerland, University of California, Berkeley, United States, Tufts University, United States, Universidad Peruana Cayetano Heredia, Peru, Tehran University of Medical Sciences, Iran, Brandeis University, United States, Mulago Hospital, Uganda, Yale University, United States, University of Lausanne, Switzerland, Ministry of Health, Seychelles, National Center for Cardiovascular Diseases, China, National Institute of Health and Nutrition, Japan, University of Auckland, New Zealand, Simon Fraser University, Canada, South African Medical Research Council, South Africa, National Institute for Health and Welfare, Finland, University of Hong Kong, Hong Kong, National Institute of Nutrition, India, Capital Medical University Beijing An Zhen Hospital, China, Robert Koch Institute, Germany, Uppsala University, Sweden, London School of Hygiene and Tropical Medicine, United Kingdom, University of Zagreb, Croatia, University of Sydney, Australia, University of Oxford, United Kingdom, Caja Costarricense de Seguro Social, Costa Rica, Al-Quds University, Palestine, Qatar University, Qatar, Birzeit University, Palestine, Instituto Mexicano del Seguro Social, Mexico, The University of Adelaide, Australia, Mahidol University, Thailand, BRAC, Bangladesh, Instituto Nacional de Ciencias Médicas y Nutricion, Mexico, University of Amsterdam, Netherlands, Non-Communicable Diseases Research Center, Iran, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Germany, Ministry of Health, Saudi Arabia, Ministry of Health, Kuwait, World Health Organization Regional Office for the Eastern Mediterranean, Egypt, Luxembourg Institute of Health, Luxembourg, Lille University and Hospital, France, Sogn and Fjordane University College, Norway, Norwegian School of Sport Sciences, Norway, Bispebjerg and Frederiksberg Hospitals, Denmark, Madras Diabetes Research Foundation, India, Komfo Anokye Teaching Hospital, Ghana, National Institute of Public Health, Tunisia, University of Porto, Portugal, Norwegian Institute of Public Health, Norway, Ministry of Health Malaysia, Malaysia, Nepal Health Research Council, Nepal, Strasbourg University and Hospital, France, University of Yaoundé 1, Cameroon, Federal University of Pelotas, Brazil, Regional Authority of Public Health, Banska Bystrica, Slovakia, University of Porto Medical School, Portugal, Shahid Beheshti University of Medical Sciences, Iran, Indian Council of Medical Research, India, King Abdulaziz University, Saudi Arabia, Medical University of Gdansk, Poland, Universidad Autónoma de Madrid, Spain, University of Palermo, Italy, Pan American Health Organization, United States, Université Mohammed V de Rabat, Morocco, University of Pernambuco, Brazil, Dalhousie University, Canada, Jordan University of Science and Technology, Jordan, University Tunis El Manar, Tunisia, University Medical Science, Cuba, University of Utah School of Medicine, United States, Lithuanian University of Health Sciences, Lithuania, University of São Paulo, Brazil, B J Medical College, India, Chirayu Medical College, India, SL Jain Hospital, India, Shanghai Jiao-Tong University School of Medicine, China, Ufa Eye Research Institute, Russian Federation, University of Southern Denmark, Denmark, University of Greenland, Greenland, University of Oslo, Norway, University of Gothenburg, Sweden, National Institute for Public Health and the Environment, Netherlands, University of Turin, Italy, University College London, United Kingdom, German Institute of Human Nutrition, Germany, Universidad de la República, Uruguay, CEMIC, Argentina, Toulouse University School of Medicine, France, Ghent University, Belgium, Universidad Central de Venezuela, Venezuela, Bielefeld University, Germany, German Cancer Research Center, Germany, Cork Institute of Technology, Ireland, Hadassah-Hebrew University Medical Center, Israel, Universidad de La Laguna, Spain, University of Malta, Malta, Canadian Fitness and Lifestyle Research Institute, Canada, Istanbul University, Turkey, Universidade Federal de Juiz de Fora, Brazil, Cardiologia di Mercato S Severino, Italy, Karolinska Institutet, Sweden, Santiago de Compostela University, Spain, Associazione Calabrese di Epatologia, Italy, India Diabetes Research Foundation, India, Duke-NUS Medical School, Singapore, National Institute of Medical Statistics, India, Academia Sinica, Taiwan, Capital Institute of Pediatrics, China, Duke University, United States, Kailuan General Hospital, China, The Gertner Institute for Epidemiology and Health Policy Research, Israel, Lausanne University Hospital, Switzerland, Ministry of Health and Welfare, Taiwan, Victor Babeș University of Medicine and Pharmacy Timisoara, Romania, Seoul National University College of Medicine, South Korea, Korea Centers for Disease Control and Prevention, South Korea, Medical University of Silesia, Poland, Charles University in Prague, Czech Republic, Katholieke Universiteit Leuven, Belgium, Agency for Preventive and Social Medicine, Austria, University of Southampton, United Kingdom, IRCCS Istituto Neurologico Mediterraneo Neuromed, Italy, Institut Pasteur de Lille, France, Westmead University of Sydney, Australia, CIBEROBN, Spain, National Council of Research, Italy, Federal University of Santa Catarina, Brazil, Eduardo Mondlane University, Mozambique, Research Centre for Prevention and Health, Denmark, Lille University Hospital, France, Erasmus Medical Center Rotterdam, Netherlands, University of Montreal, Canada, French Public Health Agency, France, Universidade do Vale do Rio dos Sinos, Brazil, National Council of Scientific and Technical Research, Argentina, National Institute of Nutrition, Viet Nam, University of Queensland, Australia, Istituto Superiore di Sanità, Italy, Universidad de Cuenca, Ecuador, Helmholtz Zentrum München, Germany, Ministère de la Santé et de la Lutte Contre le Sida, Cote d'Ivoire, The Cardinal Wyszynski Institute of Cardiology, Poland, University of Latvia, Latvia, Medical University of Łodz, Poland, National Institute of Nutrition and Food Technology, Tunisia, Institut Hospital del Mar d'Investigacions Mèdiques, Spain, University of Stellenbosch, South Africa, Karadeniz Technical University, Turkey, The Queen's University of Belfast, United Kingdom, University of Zurich, Switzerland, Centro de Salud Villanueva Norte, Spain, The University of the West Indies, Jamaica, Hospital Don Benito-Villanueva de la Serena, Spain, Ministry of Health, Argentina, Council for Agricultural Research and Economics, Italy, Pontificia Universidad Católica de Chile, Chile, University of Manchester, United Kingdom, University of Tartu, Estonia, Universiti Sains Malaysia, Malaysia, Umeå University, Sweden, Dalarna University, Sweden, Stanford University, United States, Federal University of São Paulo, Brazil, Hospital Universitario Son Espases, Spain, Hospital de Clinicas de Porto Alegre, Brazil, Universidade Federal do Rio Grande do Sul, Brazil, Kindai University, Japan, Kyoto University, Japan, Medical University of Warsaw, Poland, University of KwaZulu-Natal, South Africa, Geneva University Hospitals, Switzerland, CIBER en Epidemiología y Salud Pública, Spain, Australian Bureau of Statistics, Australia, Murcia Regional Health Council, Spain, Wageningen University, Netherlands, Endocrinology and Metabolism Research Institute, Iran, B P Koirala Institute of Health Sciences, Nepal, University of Insubria, Italy, Ministry of Health, Israel, Universidad Politécnica de Madrid, Spain, The Andes Clinic of Cardio-Metabolic Studies, Venezuela, Université de Lille 2, France, Institute for Clinical and Experimental Medicine, Czech Republic, The Children's Memorial Health Institute, Poland, Jagiellonian University Medical College, Poland, University of Novi Sad, Serbia, Singapore Eye Research Institute, Singapore, University of Iceland, Iceland, Universidad Icesi, Colombia, State University of Montes Claros, Brazil, King's College London, United Kingdom, Icelandic Heart Association, Iceland, Healis-Sekhsaria Institute for Public Health, India, University of Ibadan, Nigeria, Institute for Clinical Effectiveness and Health Policy, Argentina, Danish Cancer Society Research Centre, Denmark, The University of the West Indies, Barbados, Kyushu University, Japan, Tulane University, United States, Academic Medical Center Amsterdam, Netherlands, National Institute of Public Health, Mexico, Universitas Indonesia, Indonesia, Oulu University Hospital, Finland, Chronic Diseases Research Center, Iran, The Chinese University of Hong Kong, Hong Kong, University of Western Australia, Australia, Celal Bayar University, Turkey, Fundación Oftalmológica de Santander, Colombia, Universidade Federal de Pelotas, Brazil, University of Oran 1, Algeria, University of Public Health, Myanmar, Ministry of Health, Myanmar, Peking University, China, International Agency for Research on Cancer, France, American University of Beirut, Lebanon, Cairo University, Egypt, Aga Khan University, Pakistan, UHC Zagreb, Croatia, Niigata University, Japan, Hadassah University Medical Center, Israel, Norwegian University of Science and Technology, Norway, University of Zagreb School of Medicine, Croatia, Guangzhou 12th Hospital, China, Ruprecht-Karls-University of Heidelberg, Germany, World Health Organization Country Office, India, University of Ljubljana, Slovenia, University of Crete, Greece, Universiti Kebangsaan Malaysia, Malaysia, Johns Hopkins Bloomberg School of Public Health, United States, University of Eastern Finland, Finland, National Institute of Epidemiology, India, University of Münster, Germany, Israel Center for Disease Control, Israel, Research Institute for Primordial Prevention of Non-Communicable Disease, Iran, VU University Medical Center, Netherlands, Research Institute of Child Nutrition, Germany, Seoul National University, South Korea, University of Cambridge, United Kingdom, Medical University of Innsbruck, Austria, Muhimbili University of Health and Allied Sciences, Tanzania, National Cancer Center, South Korea, Institute of Tropical Medicine, Belgium, Tartu University Clinics, Estonia, Polish Academy of Sciences Anthropology Unit in Wroclaw, Poland, University of Groningen, Netherlands, North-West University, South Africa, National Institute of Public Health, Czech Republic, University of Jyväskylä, Finland, Amrita Institute of Medical Sciences, India, All India Institute of Medical Sciences, India, African Population and Health Research Center, Kenya, Ministerio de Salud Pública, Cuba, Sahlgrenska Academy, Sweden, Endocrinology and Metabolism Research Center, Iran, Food and Agriculture Organization, Italy, National University of Singapore, Singapore, Tampere University Hospital, Finland, Universiti Putra Malaysia, Malaysia, University of Cape Town, South Africa, West Virginia University, United States, Oswaldo Cruz Foundation Rene Rachou Research Institute, Brazil, National Taiwan University, Taiwan, University of Chinese Academy of Sciences, China, University Medicine Greifswald, Germany, Consejería de Sanidad Junta de Castilla y León, Spain, Universidade do Porto, Portugal, University of Uppsala, Sweden, Universidade Federal de Ouro Preto, Brazil, The Jikei University School of Medicine, Japan, National Research Council, Italy, Baker IDI Heart and Diabetes Institute, Australia, Hospital Israelita Albert Einstein, Brazil, Institute of Internal and Preventive Medicine, Russian Federation, Harokopio University, Greece, University of Otago, New Zealand, University of Padova, Italy, Emory University, United States, UiT The Arctic University of Norway, Norway, Cape Peninsula University of Technology, South Africa, Gorgas Memorial Institute of Health Studies, Panama, Brown University, United States, University of Edinburgh, United Kingdom, University College Dublin, Ireland, Penang Medical College, Malaysia, Institut National de la Santé et de la Recherche Médicale, France, Ain Shams University, Egypt, Hypertension Research Center, Iran, University of Pécs, Hungary, University of Limpopo, South Africa, Universidad de Zaragoza, Spain, RCSI Dublin, Ireland, International Institute of Molecular and Cell Biology, Poland, Ahvaz Jundishapur University of Medical Sciences, Iran, Gorgas Memorial Institute of Public Health, Panama, University of Brescia, Italy, Ulm University, Germany, Institute of Public Health, Malaysia, Kobe University, Japan, Suraj Eye Institute, India, INSERM, France, The University of Pharmacy and Medicine of Ho Chi Minh City, Viet Nam, Hanoi Medical University, Viet Nam, Universidad Centro-Occidental Lisandro Alvarado, Venezuela, Heartfile, Pakistan, Eastern Mediterranean Public Health Network, Jordan, Aarhus University, Denmark, Kwame Nkrumah University of Science and Technology, Ghana, Institute for Social and Preventive Medicine, Switzerland, University of Coimbra, Portugal, Cancer Prevention and Research Institute, Italy, University of Bari, Italy, Zayed University, United Arab Emirates, University Medical Center Utrecht, Netherlands, Public Health Agency of Canada, Canada, Heart Institute, Brazil, National Institute of Hygiene, Epidemiology and Microbiology, Cuba, Vietnam National Heart Institute, Viet Nam, Federal Ministry of Health, Bosnia and Herzegovina, Cardiovascular Prevention Centre Udine, Italy, University of New South Wales, Australia, Public Health Agency of Catalonia, Spain, University of Split, Croatia, Alborz University of Medical Sciences, Iran, Turku University Hospital, Finland, Julius Centre University of Malaya, Malaysia, University of Valencia, Spain, University of the Philippines, Philippines, Minas Gerais State Secretariat for Health, Brazil, Health Center San Agustín, Spain, PharmAccess Foundation, Netherlands, Canarian Health Service, Spain, Universidad Industrial de Santander, Colombia, Instituto Nacional de Salud Pública, Mexico, University of Madeira, Portugal, Sitaram Bhartia Institute of Science and Research, India, Marmara University, Turkey, University of Helsinki, Finland, National Institute of Health, Peru, Catalan Department of Health, Spain, Universidade de Lisboa, Portugal, University of Sao Paulo Clinics Hospital, Brazil, South Karelia Social and Health Care District, Finland, Robert Koch Institut, Germany, Isfahan Cardiovascular Research Center, Iran, Research and Education Institute of Child Health, Cyprus, Hospital Italiano de Buenos Aires, Argentina, Lagos State University College of Medicine, Nigeria, Digestive Diseases Research Institute, Iran, The University of Tokyo, Japan, St Vincent's Hospital, Australia, Lund University, Sweden, University of Copenhagen, Denmark, Institut Régional de Santé Publique, Benin, University of Bordeaux, France, University of Leuven, Belgium, Heart Foundation, Australia, Bonn University, Germany, Sotiria Hospital, Greece, National Institute of Public Health-National Institute of Hygiene, Poland, Fu Jen Catholic University, Taiwan, Ministry of Health, Jordan, IB-SALUT Area de Salut de Menorca, Spain, Institut de Recherche pour le Développement, France, Harvard T H Chan School of Public Health, United States, Hellenic Health Foundation, Greece, Government Medical College, India, Sefako Makgatho Health Science University, South Africa, Dasman Diabetes Institute, Kuwait, Ministry of Health, New Zealand, University of Tampere Tays Eye Center, Finland, Centro di Prevenzione Cardiovascolare Udine, Italy, Universidade Federal de Minas Gerais, Brazil, Finnish Institute of Occupational Health, Finland, Universidad Miguel Hernandez, Spain, Centre for Research in Environmental Epidemiology, Spain, University of the Witwatersrand, South Africa, University of Strasbourg, France, University College Cork, Ireland, Institute for Medical Research, Malaysia, Xinjiang Medical University, China, Beijing Tongren Hospital, China, St George's, University of London, United Kingdom, Medical University of Vienna, Austria, Institute of Food and Nutrition Development of Ministry of Agriculture, China, Children's Hospital of Fudan University, China, Chinese Center for Disease Control and Prevention, China, University of Cyprus, Cyprus, Ministry of Health, Malaysia, and Inner Mongolia Medical University, China
- Abstract
Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings We pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. In 2015, central and eastern Europe, sub-Saharan Africa, and south Asia had the highest blood pressure levels. Prevalence of raised blood pressure decreased in high-income and some middle-income countries; it remained unchanged elsewhere. The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries. The global increase in the number of adults with raised blood pressure is a net effect of increase due to population growth and ageing, and decrease due to declining age-specific prevalence. Interpretation During the past four decades, the highest worldwide blood pressure levels have shifted from high-income countries to low-income countries in south Asia and sub-Saharan Africa due to opposite trends, while blood pressure has been persistently high in central and eastern Europe. Funding Wellcome Trust. © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license
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- 2017
25. Involuntary outsiders or those just taking time off? Young people who are not in education, employment or training in Estonia
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Kairi Kasearu, Dagmar Kutsar, Avo Trumm, Grotowska-Leder, Jolanta, Rokicka, Ewa, University of Tartu, Estonia, Kairi Kasearu Doktor socjologii, wykładowca na Uniwersytecie w Tartu. Jej zainteresowania badawcze koncentrują się wokół rodziny i polityki rodzinnej, w tym struktur rodziny i relacji międzypokoleniowych. Doctor of sociology, a lecturer of Sociology at the University of Tartu in Estonia. Her research interests are family and family policies, i.e. family structures and intergenerational relations., Dagmar Kutsar Profesor polityki społecznej Uniwersytetu w Tartu w Estonii. Jej zainteresowania badawcze dotyczą problematyki rodziny i dzieciństwa oraz polityki społecznej. Jest członkiem Komitetu Nauk Społecznych Europejskiej Fundacji Nauki. Professor of social policy at the University of Tartu in Estonia. Her research interests are family, childhood and welfare research and policies. She is a member of a Standing Committee of Social Sciences of the European Science Foundation and member of the Executive Committee., and Avo Trumm Doktor sociologii na Uniwersytecie w Tartu. Jego zainteresowania badawcze dotyczą polityki społecznej, ubóstwa i wykluczenia społecznego. Doctor of sociology, a lecturer of Sociology at the University of Tartu in Estonia. His research interests are poverty and social exclusion and social policy.
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Estonia ,unemployment ,outsider ,młodzież ,NEET ,wykluczeni ,Demographic economics ,Psychology ,Training (civil) ,young people - Abstract
Artykuł jest omówieniem sytuacji osób młodych, które nie uczestniczą w systemie edukacyjnym, nie są zatrudnieni i nie uczestniczą w szkoleniach w Estoni. Autorzy artykułu zadają pytania o przyczyny ich wypadnięcia z normalnego przebiegu tranzycji do niezależnej dorosłości. Wykorzystując dane Estonian Labour Force Survey (2011) oraz 15 wywiadów swobodnych z poszukiwaną listą dyspozycji przeprowadzonych w 2012 r., autorzy wskazują na wewnętrzne zróżnicowanie sytuacji tej grupy młodych: oprócz osób będących niedobrowolnymi outsiderami, wskazują grupę młodych, którzy wycofali się z własnego wyboru. Obie grupy są jednak wykluczone ze społecznych mechanizmów i regulacji, stąd wymagają społecznej i politycznej uwagi. Udostępnienie publikacji Wydawnictwa Uniwersytetu Łódzkiego finansowane w ramach projektu „Doskonałość naukowa kluczem do doskonałości kształcenia”. Projekt realizowany jest ze środków Europejskiego Funduszu Społecznego w ramach Programu Operacyjnego Wiedza Edukacja Rozwój; nr umowy: POWER.03.05.00-00-Z092/17-00.
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- 2013
- Full Text
- View/download PDF
26. Sprawozdanie o stanie gospodarki Estonii oraz postępach w zakresie budowy wielosektorowego modelu estońskiej gospodarki
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Grassini, Maurizio, Paas, Tiiu, University of Florence, Italy, and University of Tartu, Estonia
- Abstract
W opracowaniu przedstawiono rozwój gospodarki Estonii w ostatnich latach w świetle danych International Institute of Management Development (IMD) World Competitiveness Yearbook (WCY) oraz wskaźnika wzrostu konkurencyjności szacowanego przez Światowe Forum Ekonomiczne. Estonia jawi się jako najbardziej konkurencyjny pośród europejskich krajów postsocjalistycznych. Gospodarka Estonii opiera się na wolności ekonomicznej i otwartości. Do szybkiego rozwoju tego bałtyckiego kraju przyczyniły się liberalizacja gospodarki, wsparcie finansowe Unii Europejskiej oraz duża ilość bezpośrednich inwestycji zagranicznych. Obecnie estońska polityka finansowa i dtug publiczny w pełni odpowiada kryteriom strefy euro. Wprowadzenie tej waluty jest jed nym z priorytetów rządu, i można się spodziewać, że w najbliższym okresie stanie się faktem. Druga część opracowania zawiera opis makroekonomicznego, wielosektorowego modelu gospodarki Estonii w jego obecnym kształcie. Powstaje on w ramach współpracy naukowej pomiędzy Uniwersytetem Tartu i Uniwersytetem Florenckim. Model ten korzysta z podejścia INFORUM. Pomimo, że dostępność danych dla Estonii jest wciąż niewielka (jak to zresztą jest w przypadku wielu nowych członów UE, wprowadzających dopiero standardy Eurostatu), udało się oszacować bloki równań opisujące udziały importu oraz wydajność pracy. Bloki te zostały włączone do modelu, opartego na tablicy input-output. Wyniki symulacji otrzymane przy zastosowaniu scenariusza zaproponowanego przez estońskie ministerstwo gospodarki wskazuje możliwości wykorzystania tego typu podejścia modelowego dla celów polityki ekonomicznej. Zadanie pt. „Digitalizacja i udostępnienie w Cyfrowym Repozytorium Uniwersytetu Łódzkiego kolekcji czasopism naukowych wydawanych przez Uniwersytet Łódzki” nr 885/P-DUN/2014 zostało dofinansowane ze środków MNiSW w ramach działalności upowszechniającej naukę.
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- 2006
27. Do probiotic preparations for humans really have efficacy?
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Gianfranco Donelli, Andrew B. Onderdonk, Marika Mikelsaar, Veronica Lazar, and University of Tartu, Estonia
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medicine.drug_class ,Antibiotics ,infectious diarrhea ,intestinal microbial ecology ,Inflammatory bowel disease ,lcsh:Microbial ecology ,Microbiology ,law.invention ,Probiotic ,mono-strain probiotics, multi-strains probiotics, multi-species probiotics, intestinal microbial ecology, infectious diarrhea, antibiotic treatment, Helicobacter pylori, Clostridium difficile infections, inflammatory bowel disease, irritable bowel syndrom ,Immune system ,inflammatory bowel disease ,law ,medicine ,multispecies probiotics ,mono-strain probiotics ,Irritable bowel syndrome ,irritable bowel syndrome ,Helicobacter pylori ,biology ,Antimicrobial ,medicine.disease ,biology.organism_classification ,Clostridium difficile infections ,Diarrhea ,multistrain probiotics ,antibiotic treatment ,Immunology ,lcsh:QR100-130 ,medicine.symptom - Abstract
Microbial ecology studies have provided convincing evidence for the crosstalk between members of the autochthonous microbiota and the host immune system. The tight interrelationship between microbiota and host mucosal cells are mediated by microbial metabolites that are responsible for bacterial cell-to-cell communication by quorum-sensing mechanisms and also through the activation of eukaryotic cells following secretion of host defensins and modulation of cytokine expression profiles. All these host functions can be positively influenced by probiotic bacteria of human origin. However, few requirements for evaluating these strains for use in humans have been set according to their composition and metabolic activity. In this article, we have reported the scientific data published to date on the advantages of either mono- or multispecies probiotic products based on the outcome of the most significant clinical trials. According to published clinical trials, the efficacy of probiotic intervention for infectious or antimicrobial treatment-induced diarrhea, caused by different opportunistic bacterial or viral pathogens, was 48%. The probiotic preparations’ efficacy for silencing the clinical symptoms of IBS was 75% and for attenuating the inflammatory response during IBD was 83% whereas multistrain probiotics appear to have better efficacy. Keywords: mono-strain probiotics; multistrain probiotics; multispecies probiotics; intestinal microbial ecology; infectious diarrhea; antibiotic treatment; Helicobacter pylori; Clostridium difficile infections; inflammatory bowel disease; irritable bowel syndrome (Published: 6 December 2011) Citation: Microbial Ecology in Health & Disease 2011, 22 : 10128 - DOI: 10.3402/mehd.v22i0.10128 This article has been commented on by Tore Midtvedt, Editor-in-Chief. Please follow this link http://www.microbecolhealthdis.net/index.php/mehd/article/view/11620 to read his Editorial Remarks
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- 2011
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28. TEACHERS' CONCEPTIONS ON ENVIRONMENT AND GMO IN TWELVE EUROPEAN COUNTRIES
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Pierre Clément, Jérémy Castéra, Charline Laurent, Silvia Caravita, Anna-Liisa Rauma-Kosonen, Attila Varga, Jurga Turcinaviciene, Elwira Samonek-Miciuk, Adrienne Kozan-Naumescu, Paul Pace, Kai Pata, Nicos Valanides, Franz Bogner, Graça Carvalho, Clément, Pierre, Biohead-Citizen (n° 506015, FP6, Priority 7: 'Biology, Health and Environmental Education for better - INCOMING, S. Dolinšek & T. Lyons, Sciences et Société, Historicité, Éducation et Pratiques (EA S2HEP), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Apprentissage, Didactique, Evaluation, Formation (ADEF), Aix Marseille Université (AMU), Istituto di Scienze e Tecnologie della Cognizione del C.N.R, Rome, Italie, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), University of Joensuu, Finland, National Institute for Public Education, Hungary, Vilnius University [Vilnius], University of Lublin, Poland, Babes-Bolyai University [Cluj-Napoca] (UBB), University of Malta [Malta], University of Tartu, University of Cyprus = Université de Chypre, Universität Bayreuth, Centro de Investigação em Estudos da Criança (CIEC), Universidade do Minho = University of Minho [Braga], European Project, École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Consiglio Nazionale delle Ricerche [Roma] (CNR), University of Tartu, Estonia, University of Cyprus, Cyprus, and Universidade do Minho
- Subjects
[SDV.EE]Life Sciences [q-bio]/Ecology, environment ,Europe ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,[SDV.EE] Life Sciences [q-bio]/Ecology, environment ,teachers ,GMO ,[SHS.EDU]Humanities and Social Sciences/Education ,Environmental Education ,[SHS.EDU] Humanities and Social Sciences/Education ,values ,conceptions ,[SDV.GEN] Life Sciences [q-bio]/Genetics - Abstract
International audience; We analyze the conceptions of 4248 teachers on Environment and GMO (Genetically Modified Organisms), in 12 European countries: Cyprus, Estonia, Finland, France, Germany, Hungary, Italy, Lithuania, Malta, Poland, Portugal, Romania. Most of the differences between teachers' conceptions are observed inside each country. Some of them (related to preservation or utilization of Environment) significantly differentiate the 12 countries. Biology teachers have more knowledge on GMO and more opinions pro- GMO than their colleagues. Female teachers are significantly more anti-GMO than their male colleagues. More a teacher studied at University, more he or she thinks that the resources of our planet are limited.
29. Association Between Self-Perceived Stress and Cryptogenic Ischemic Stroke in Young Adults: A Case-Control Study.
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Kutal S, Tulkki LJ, Sarkanen T, Redfors P, Jood K, Nordanstig A, Yeşilot N, Sezgin M, Ylikotila P, Zedde M, Junttola U, Fromm A, Ryliskiene K, Licenik R, Ferdinand P, Jatužis D, Kõrv L, Kõrv J, Pezzini A, Sinisalo J, Lehto M, Gerdts E, Autere J, Fonseca AC, Waje-Andreassen U, Von Sarnowski B, Sairanen T, Tatlisumak T, Huhtakangas J, Jäkälä P, Putaala J, and Martinez-Majander N
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- Humans, Female, Male, Adult, Case-Control Studies, Young Adult, Adolescent, Middle Aged, Risk Factors, Stress, Psychological epidemiology, Stress, Psychological psychology, Ischemic Stroke epidemiology, Ischemic Stroke psychology
- Abstract
Background and Objectives: Psychosocial stress is a potentially modifiable risk factor of early-onset ischemic stroke, with limited evidence suggesting a stronger association between stress and cryptogenic ischemic stroke (CIS) compared with strokes of known etiology. We aimed to explore the association between self-perceived stress and CIS, with subgroup analyses stratified by sex and age., Methods: Young patients aged 18-49 years with a first-ever CIS and sex-matched and age-matched stroke-free controls from 19 European centers were included. Self-perceived stress was assessed using a modified version of the Perceived Stress Scale (PSS). Scores were categorized into low (0-13), moderate (14-26), and high (27-40) perceived stress. Conditional logistic regression-adjusted for age, level of education, traditional risk factors (hypertension, cardiovascular diseases, diabetes mellitus, heavy alcohol consumption, current smoking, obesity, diet, depression, and physical inactivity), and migraine with aura (MA)-was used to assess independent association between self-perceived stress and CIS., Results: Altogether, 426 patients (median age 41 years; 47.7% women) and 426 controls were included. Patients were more often at least moderately stressed compared with controls (46.2% vs 33.3%, p < 0.001). In the entire study population, higher self-perceived stress as a discrete measure was independently associated with CIS: adjusted odds ratio (OR) 1.04 per point increase; 95% CI 1.01-1.07. Categorical PSS score analysis showed an independent association between moderate stress and CIS (OR 1.47; 95% CI 1.00-2.14), but not with high stress (2.62; 0.81-8.45). In sex-specific analysis, higher stress as a discrete measure was associated with CIS in women (1.06; 1.02-1.11), but not in men (1.02; 0.97-1.07). Moderate stress was associated with CIS in women (1.78; 1.07-2.96), but not in men (1.06; 0.58-1.96). When stratified by age, higher stress as a discrete measure was significantly associated with CIS only in patients aged 18-39 years (1.06; 1.00-1.11)., Discussion: Self-perceived stress was strongly correlated with an increased risk of early-onset CIS, even after robust adjustment for cardiovascular risk factors and MA. These findings highlight the need for further investigation into the mechanisms by which stress may contribute to the risk of CIS. Possibility of recall bias should be considered when interpreting the results., Trial Registration Information: Clinical trial registration number: NCT01934725.
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- 2025
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30. Assessment of the Spiritual Needs of People With Amyotrophic Lateral Sclerosis and Their Caregivers.
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Brandstötter C, Büssing A, Eham M, Littger B, Lorenzl S, Memmel M, Paal P, and Bublitz SK
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Context: Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disorder which poses multidimensional burden to patients and caregivers., Objectives: This study aimed to investigate spiritual needs in people with Amyotrophic Lateral Sclerosis (pALS) and their closest caregivers, and to identify factors which may contribute to these needs., Methods: Spiritual needs were assessed based on the Spiritual Needs Questionnaire (SpNQ) as part of a longitudinal cohort study in pALS and their closest caregivers who were included in a multiprofessional pilot project for ALS in Southern Germany with a focus on neuropalliative care., Results: About 61 pALS and 52 caregivers were assessed for their spiritual needs. We show that both pALS and their caregivers maintain stable and distinct spiritual needs over time, irrespective of age, gender, care setting, or perceived level of loneliness. While pALS emphasize generativity and inner peace needs, caregivers primarily focus on finding inner peace, which they value even more than pALS., Conclusions: Both pALS and their caregivers have strong unmet spiritual, and particularly nonreligious needs, which should be regularly assessed by the interprofessional team. Documenting these needs is the initial step in the spiritual care process, which requires a collaborative response from the interprofessional team. All healthcare professionals involved in ALS care should be attuned to the potential for unmet spiritual needs in patients and their caregivers. Early identification of these needs can facilitate the initiation of appropriate support processes., (Copyright © 2025 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2025
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31. The PAZ domain of Aedes aegypti Dicer 2 is critical for accurate and high-fidelity size determination of virus-derived small interfering RNAs.
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Reuter M, Parry RH, McDonald M, Gestuveo RJ, Arif R, Khromykh AA, Brennan B, Varjak M, Castello A, Redecke L, Schnettler E, and Kohl A
- Abstract
The exogenous siRNA (exo-siRNA) pathway is a critical RNA interference response involved in controlling arbovirus replication in mosquito cells. It is initiated by the detection of viral long double-stranded RNA (dsRNA) by the RNase III enzyme Dicer 2 (Dcr2), which is processed into predominantly 21 nucleotide (nt) virus-derived small interfering RNAs, or vsiRNAs that are taken up by the Argonaute 2 (Ago2) protein to target viral single-stranded RNAs. The detailed understanding of Dicer structure, function and domains owes much to studies outside the context of viral infection and studies in model organisms, and as such how Dcr2 domains contribute to detecting viral dsRNA to mount antiviral responses in infected mosquito cells remains less well understood. Here, we used a Dcr2 reconstitution system in Aedes aegypti derived Dcr2 KO cells to assess the contribution of the PAZ domain to induction of the exo-siRNA pathway following infection with Semliki Forest virus (SFV; Togaviridae, Alphavirus). Amino acids critical for PAZ activity were identified, and loss of PAZ function affected the production of 21 nt vsiRNAs -with enrichment of 22 nt SFV-derived small RNAs observed- and silencing activity. This study establishes PAZ domain's functional contribution to Dcr2 processing of viral dsRNA to 21 nt vsiRNAs., (Published by Cold Spring Harbor Laboratory Press for the RNA Society.)
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- 2025
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32. Prolactin levels increased by physical exercise correlate with platelet monoamine oxidase activity: Evidence linking platelet MAO with serotonin release capacity.
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Harro J, Eensoo D, Suvi S, Timpmann S, and Ööpik V
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- Humans, Male, Adult, Young Adult, Aldosterone blood, Aldosterone metabolism, Hydrocortisone blood, Hydrocortisone metabolism, Monoamine Oxidase blood, Monoamine Oxidase metabolism, Serotonin blood, Serotonin metabolism, Prolactin blood, Blood Platelets metabolism, Exercise physiology
- Abstract
Objective: Lower platelet monoamine oxidase (MAO) activity has consistently been associated with excessive risk-taking and general psychiatric vulnerability. How this peripheral measure can represent presumably centrally regulated complex behaviours is not clear but platelet MAO activity has been suggested to reflect the capacity of serotonin release in the brain. Secretion of prolactin is in part under serotonergic control and indicates serotonin release capacity., Methods: We have assessed release of prolactin and other exercise-induced hormones in response to strenuous physical exercise in twenty male subjects and examined its association with platelet MAO activity as measured radioenzymatically., Results: Increase in prolactin levels was positively correlated with platelet MAO activity. Levels of cortisol, growth hormone and aldosterone were also raised by exercise, but these increases were not associated with platelet MAO activity. Unexpectedly, aldosterone levels before exercise were also in a positive correlation with platelet MAO activity., Conclusion: The finding that exercise-induced prolactin release is associated with MAO activity in platelets indirectly supports the notion that platelet MAO activity is a marker of central serotonin release capacity., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 Elsevier B.V. All rights reserved.)
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- 2025
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33. Personality nuances and cognition: A multi-cohort and multi-method approach.
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Stephan Y, Sutin AR, Mõttus R, Luchetti M, Aschwanden D, and Terracciano A
- Abstract
There is substantial evidence for an association between the Five-Factor Model personality domains and cognition across adulthood. Examining the items that compose each of the five domains, known as nuances, can provide novel insight into the aspects of the traits most connected to cognitive outcomes. This study tested the association between personality nuances and cognition (memory performance, subjective memory, informant-rated cognition) in five community-based cohorts. Participants (N > 28,000, age range: 32-104 years) were administered the Midlife Development Inventory (MIDI) to assess personality nuances, immediate and recall tasks to assess memory performance, and a subjective memory measure. Ratings of cognitive functioning from a knowledgeable informant were available in two samples. There was a strong pattern of replicability between personality items and cognitive outcomes across samples and cognitive measures. Meta-analyses indicated that higher neuroticism nuances (particularly the nervous and worry items) were related to lower memory performance, worse subjective memory, and worse informant-rated cognition. Higher conscientiousness (particularly the organized and responsible items), extraversion (particularly the active item), and openness (particularly the intelligent item) nuances were consistently associated with better memory performance, better subjective memory, and better informant-rated cognition across samples. To a lesser extent, higher agreeableness nuances (helpful, warm, sympathetic) were associated with better memory and subjective memory. This research adds to the existing literature by providing novel evidence of replicable associations between personality nuances and cognition., Competing Interests: Declaration of competing interest None., (Copyright © 2025 Elsevier Ltd. All rights reserved.)
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- 2025
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34. Navigating Climate Change: Exploring the Dynamics Between Plant-Soil Microbiomes and Their Impact on Plant Growth and Productivity.
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Muhammad M, Wahab A, Waheed A, Hakeem KR, Mohamed HI, Basit A, Toor MD, Liu YH, Li L, and Li WJ
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- Agriculture methods, Crops, Agricultural growth & development, Crops, Agricultural microbiology, Plants microbiology, Rhizosphere, Climate Change, Soil Microbiology, Microbiota, Plant Development
- Abstract
Understanding the intricate interplay between plant and soil microbiomes and their effects on plant growth and productivity is vital in a rapidly changing climate. This review explores the interconnected impacts of climate change on plant-soil microbiomes and their profound effects on agricultural productivity. The ongoing rise in global temperatures, shifting precipitation patterns and extreme weather events significantly affect the composition and function of microbial communities in the rhizosphere. Changes in microbial diversity and activity due to rising temperatures impact nutrient cycling, microbial enzyme synthesis, soil health and pest and disease management. These changes also influence the dynamics of soil microbe communities and their capability to promote plant health. As the climate changes, plants' adaptive capacity and microbial partners become increasingly crucial for sustaining agriculture. Mitigating the adverse effects of climate change on plant growth and agricultural productivity requires a comprehensive understanding of the interconnected mechanisms driving these processes. It highlights various strategies for mitigating and adapting to environmental challenges, including soil management, stress-tolerant crops, cover cropping, sustainable land and water management, crop rotation, organic amendments and the development of climate-resilient crop varieties. It emphasises the need for further exploration of plant-soil microbiomes within the broader context of climate change. Promising mitigation strategies, including precision agriculture and targeted microbiome modifications, offer valuable pathways for future research and practical implementation of global food security and climate change., (© 2025 John Wiley & Sons Ltd.)
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- 2025
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35. Parsing reward sensitivity reveals distinct relationships with energy intake, metabolic markers, physical activity and fitness.
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Kiive E, Katus U, Eensoo D, Villa I, Mäestu J, Veidebaum T, and Harro J
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- Humans, Adolescent, Male, Female, Adult, Longitudinal Studies, Young Adult, Blood Pressure physiology, Estonia, Physical Fitness physiology, Physical Fitness psychology, Biomarkers blood, Triglycerides blood, Exercise physiology, Exercise psychology, Reward, Energy Intake physiology
- Abstract
Rewards are rewarding owing to their hedonic or metabolic value. Individual differences in sensitivity to rewards are predictive of mental health problems but may reflect variation in metabolic types. We have assessed the association of two distinguishable aspects of reward sensitivity, openness to rewards (the striving towards multiple rewards) and insatiability by reward (the strong pursuit and fixation to a particular reward), with measures of metabolism and activity in a longitudinal study of representative birth cohort samples. We used data of the Estonian Children Personality Behaviour and Health Study (original n = 1238) collected at age 15, 18 and 25. Reward sensitivity and physical activity were self-reported during a laboratory visit, when also blood sampling, measurement of blood pressure, height and weight, aerobic exercise testing and the diet interview, after the participants had kept food diary, took place. In the younger cohort, physical activity was also assessed by accelerometry at age 18 and 25. Across adolescence and young adulthood, openness to rewards was positively associated with physical activity and negatively with blood pressure and serum levels of glucose, insulin and cholesterol levels. In contrast, insatiability by reward was positively associated with serum triglyceride levels and negatively with energy intake and cardiorespiratory fitness. In conclusion, the two facets of reward sensitivity have a fairly different association with a variety of metabolic and health-related measures. This may explain the variable findings in literature, and suggests that individual differences in reward sensitivity are part of a complex physiological variability, including energy expenditure profiles.
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- 2025
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36. Impact of land conversion on environmental conditions and methane emissions from a tropical peatland.
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Wong GX, Hirata R, Hirano T, Kiew F, Waili JW, Mander Ü, Soosaar K, and Melling L
- Abstract
Tropical peatlands are significant sources of methane (CH₄), but their contribution to the global CH₄ budget remains poorly quantified due to the lack of long-term, continuous and high-frequency flux measurements. To address this gap, we measured net ecosystem CH
4 exchange (NEE-CH4 ) using eddy covariance technique throughout the conversion of a tropical peat swamp forest to an oil palm plantation. This encompassed the periods before, during and after conversion periods from 2014 to 2020, during which substantial environmental shifts were observed. Draining the peatland substantially lowered mean monthly groundwater levels from -20.0 ± 14.2 cm before conversion to -102.3 ± 31.6 cm during conversion and increased slightly to -96.5 ± 19.3 cm after conversion. Forest removal increased mean monthly soil temperature by 2.3 to 3.1 °C, reducing net radiation (Rn ) and raising vapor pressure deficit (VPD). Following the tree removal, controlled burning temporarily warmed air temperature by 8 °C, increased VPD and significantly attenuated Rn , resulting in negative values owing to radiation interception by smoke and increased surface warming. Contrary to expectations that drainage would lower CH4 emissions, the site remained a consistent net source, with even higher emissions observed during and after conversion. The mean monthly NEE-CH4 during conversion (23.3 ± 8.6 mg C m-2 d-1 ) was about 2-times higher than before conversion (12.1 ± 5.3 mg C m-2 d-1 ) and about 1.5-times higher than after conversion (16.3 ± 4.1 mg C m-2 d-1 ). The heightened CH4 release is likely attributable to emissions from drainage ditches, underscoring their significant role in post-conversion CH4 dynamics. Despite its short duration, controlled burning substantially elevated NEE-CH4 , ranging from 0.04 to 0.91 mg C m-2 s-1 . Our findings highlight the substantial impact of land conversion on peatland CH4 dynamics, emphasizing the need for accurate flux measurements across various conversion stages to refine global CH4 budgets., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 Elsevier B.V. All rights reserved.)- Published
- 2025
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37. Diagnostic Features of Childhood Apraxia of Speech: A Survey Study of Estonian, Finnish, and Lithuanian Speech-Language Pathologists.
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Lahtein-Kürsa M, Padrik M, Daniutė S, Kairienė D, Martikainen AL, Vanhala-Haukijärvi M, and Mailend ML
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- Humans, Estonia epidemiology, Lithuania epidemiology, Finland epidemiology, Child, Female, Male, Adult, Surveys and Questionnaires, Middle Aged, Predictive Value of Tests, Speech-Language Pathology methods, Apraxias diagnosis
- Abstract
Purpose: The primary aim of this study was to investigate how speech-language pathologists (SLPs) from Estonia, Finland, and Lithuania rate the significance of different features for diagnosing childhood apraxia of speech (CAS) in their languages., Method: An online survey was conducted among 197 Estonian, Finnish, and Lithuanian SLPs who have worked with children with CAS. The SLPs were asked to rate the significance of 63 features for CAS diagnosis in their respective language. Cross-linguistic patterns in diagnostic features were examined with simple correspondence analysis (SCA) and via descriptive statistics., Results: The ratings revealed six to seven diagnostic features that were considered very significant for CAS diagnosis by the majority of respondents in each country. The SCA highlighted differences between Lithuanian SLPs and Estonian and Finnish SLPs. Some possible language-specific associations were noted, such as palatalization errors for Lithuanian and Estonian and diphthong distortions for Estonian. The respondents from all countries rated highly those features that can easily be applied to most languages (e.g., groping) and gave lower ratings to features that may be influenced by the linguistic structure of different languages (e.g., word stress errors)., Conclusions: Overall, SLPs provided high ratings to CAS features that occur universally across languages, whereas features specific to languages, such as prosody-related errors, were not as highly rated. Several language-specific features were highlighted, providing direction for future research and emphasizing the importance of language-specific considerations in CAS research and diagnosis.
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- 2025
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38. The road to Aha: A recipe for mental breakthroughs.
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Tulver K, Kaup KK, and Aru J
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- Humans, Models, Psychological, Self Concept, Problem Solving physiology
- Abstract
We present a novel framework for understanding the diverse spectrum of mental breakthrough events, ranging from problem-solving insights to profound personal transformations. We propose that these events, while varied in expression and impact, share common underlying mechanisms of representational change. We also hypothesise that the differences in phenomenological intensity can be conceptualized along a continuum. Central to our model are three core components - tension, altered salience, and enhanced flexibility - which we identify as essential prerequisites for significant cognitive restructuring. These components interact within an iterative cycle, influencing both the emergence and nature of insight experiences. Drawing on examples from different fields, we explore how a conflict between existing models can trigger this cycle, wherein mechanisms of attention allocation and relaxation of constraints work in tandem to facilitate the emergence of insights. Furthermore, we propose that the intensity of the "aha-moment" and the breadth of its impact are contingent on how central the conflict is within one's conceptual landscape and the extent to which existing mental models are challenged. Thus, the model accounts for both the subtle, momentary insights in problem-solving and the transformative realizations that reshape core beliefs and self-perception. By synthesising insights from various domains, including psychotherapy, contemplative science, and psychedelic research, we present a theoretical account with broad scope, aiming to shed light on the complex processes that can lead to a wide array of mental breakthroughs, thereby contributing to the understanding of insight phenomena across disciplines., (Copyright © 2025 Elsevier B.V. All rights reserved.)
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- 2025
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39. StarPhase: Comprehensive Phase-Aware Pharmacogenomic Diplotyper for Long-Read Sequencing Data.
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Holt JM, Harting J, Chen X, Baker D, Saunders CT, Kronenberg Z, Gonzaludo N, Yoo B, Hudjashov G, Jõeloo M, Lawlor JMJ, Lim WK, Jamuar SS, Cooper GM, Milani L, Pastinen T, and Eberle MA
- Abstract
Pharmacogenomics is central to precision medicine, informing medication safety and efficacy. Pharmacogenomic diplotyping of complex genes requires full-length DNA sequences and detection of structural rearrangements. We introduce StarPhase, a tool that leverages PacBio HiFi sequence data to diplotype 21 CPIC Level A pharmacogenes and provides detailed haplotypes and supporting visualizations for HLA-A , HLA-B , and CYP2D6 . StarPhase diplotypes have high concordance with benchmarks where 99.5% are either exact matches or minor discrepancies. Manual inspection of the 0.5% mismatches indicates they were correctly called by StarPhase. With StarPhase, we update or correct 26.2% of GeT-RM pharmacogenomic diplotypes. Population distributions from StarPhase mostly reflect those of the All of Us cohort, while also highlighting gaps in existing pharmacogenomic databases that long-read sequencing can fill. With a single HiFi whole genome sequencing assay, StarPhase enables robust PGx diplotyping even as additional pharmacogenes and haplotypes are discovered.
- Published
- 2024
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40. Erectile dysfunction as a predictive indicator of asymptomatic diabetes and prediabetes.
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Becker S, Suija K, Valpas A, Koiranen M, Auvinen J, Uusitalo H, Hussi E, Keinänen-Kiukaanniemi S, Tuomilehto J, and Saramies J
- Subjects
- Humans, Male, Risk Factors, Middle Aged, Prevalence, Time Factors, Incidence, Aged, Odds Ratio, Surveys and Questionnaires, Predictive Value of Tests, Penile Erection, Registries, Primary Health Care, Chi-Square Distribution, Prognosis, Logistic Models, Risk Assessment, Prediabetic State diagnosis, Prediabetic State epidemiology, Prediabetic State blood, Erectile Dysfunction epidemiology, Erectile Dysfunction diagnosis, Erectile Dysfunction blood, Glucose Tolerance Test, Blood Glucose metabolism, Biomarkers blood, Diabetes Mellitus epidemiology, Diabetes Mellitus diagnosis, Diabetes Mellitus blood, Asymptomatic Diseases
- Abstract
Aims: Both erectile dysfunction (ED) and diabetes (DM) are common health problems that share risk factors. The aim of this study was to investigate whether ED can predict glucose metabolism dysfunctions in men at the primary care level., Methods: An 11-year population-based cohort study was conducted in men born between 1933 and 1956. The baseline survey was conducted in 2007-2008, with a follow-up examination 11 years later. The International Index of Erectile Function (IIEF-5) questionnaire was used to assess erectile function. Dysglycemia was evaluated using and a 2-hour oral glucose tolerance test (2hOGTT), in combination with health registry data., Results: At baseline, men with ED but without a history of known DM exhibited a significantly higher prevalence of undetected DM, odds ratio (OR) 4.7 (95 % CI 1.6, 14.4), and preDM, OR 1.9 (1.1, 3.2), compared with men without ED. Over an 11-year follow-up period, a significantly increased cumulative incidence of DM was observed in men who reported symptoms of ED at the start of the study., Conclusions: The symptoms of ED appear to be an early warning sign of existing DM and preDM and predict an increased risk of developing abnormal glucose metabolism in the future., (Copyright © 2024 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.)
- Published
- 2024
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41. D-Dimer in Acute Mesenteric Venous Thrombosis: A Prospective Case-Control International Multicenter Study.
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Acosta S, Blaser AR, Nuzzo A, Soltanzadeh-Naderi Y, Starkopf J, Forbes A, Murruste M, Tamme K, Voomets AL, Koitmäe M, Bala M, Bodnar Z, Casian D, Demetrashvili Z, Biloslavo A, Muñoz-Cruzado VD, Hess B, Kase K, Kirov M, Lindner M, Loudet CI, Damaskos D, and Björck M
- Abstract
Background: Acute mesenteric venous thrombosis (MVT) is rarely suspected as primary diagnosis in emergency departments and still carries an in-hospital mortality rate of above 20%., Objectives: The aim of this study was to find differences in clinical and laboratory markers between patients with acute MVT and a control group of suspected but confirmed as not having any type of acute mesenteric ischaemia (AMI)., Design: Data was retrieved from the AMESI (Acute MESenteric Ischaemia) study. This international, multicenter prospective case-control study from 32 sites collected data on patients with suspected AMI during a 10-month period., Methods: Independent factors associated with acute MVT were evaluated in a multivariable logistic regression analysis and expressed as odds ratios (OR) with 95% confidence intervals (CI)., Results: D-dimer was not significantly higher in MVT (n = 73) compared to non-AMI (n = 287) patients (median 7.0 mg/L vs 4.5 mg/L, P = .092). After entering BMI, atherosclerotic disease, history of venous thromboembolism, CRP, and D-dimer as covariates in a multi-variable logistic regression analysis, absence of atherosclerotic disease (OR 0.096, 95% CI 0.011-0.84; P = .034) and elevated D-dimer (OR 2.59/one SD increment, 95% CI 1.07-6.28; P = .034) were associated with MVT. The discriminative ability of D-dimer for MVT as assessed by area under the curve in the receiver operating characteristics analysis was 0.63 (95% CI 0.49-0.78)., Conclusion: Elevated D-dimer was associated with MVT, but the discriminative ability of D-dimer was poor. There is an urgent need to find a more accurate plasma biomarker for this condition., Trial Registration: NCT05218863 (registered 19.01.2022)., (© The Author(s) 2024.)
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- 2024
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42. Associations of Cardiovascular Health Metrics in Childhood and Adolescence With Arterial Health Indicators in Adolescence: The PANIC Study.
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Kraav J, Zagura M, Viitasalo A, Soininen S, Veijalainen A, Kähönen M, Jürimäe J, Tillmann V, Haapala E, and Lakka T
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- Adolescent, Child, Female, Humans, Male, Adiposity, Age Factors, Blood Glucose metabolism, Body Mass Index, Cross-Sectional Studies, Exercise physiology, Health Status, Heart Disease Risk Factors, Longitudinal Studies, Risk Factors, Blood Pressure physiology, Cardiorespiratory Fitness, Cardiovascular Diseases epidemiology, Cardiovascular Diseases physiopathology, Cardiovascular Diseases diagnosis, Carotid Intima-Media Thickness, Pulse Wave Analysis, Vascular Stiffness physiology
- Abstract
Background: Our aim was to assess the relationships of cardiovascular health metrics, cardiorespiratory fitness, lean mass, and fat percentage with arterial structure and function from childhood to adolescence., Methods and Results: Five hundred four children aged 6 to 9 years were examined in the PANIC (Physical Activity and Nutrition in Children) study at baseline, 2 and 8 years later. The associations of adjusted American Heart Association cardiovascular health metrics (smoking status, body mass index-SD score, moderate-to-vigorous physical activity, diet quality, plasma total cholesterol, systolic blood pressure, plasma glucose categorized into poor, intermediate, and ideal), the American Heart Association cardiovascular health score, cardiorespiratory fitness measured by maximal oxygen uptake in a bicycle exercise test, lean mass and fat percentage with carotid intima-media thickness (cIMT) and pulse wave velocity (PWV) were analyzed cross-sectionally and longitudinally in 277 participants at age 15 to 17 years. Higher American Heart Association cardiovascular health score at baseline was associated with lower PWV at 8-year follow-up (ß, -0.19 [95% CI, -0.32 to -0.05]). Higher body mass index-SD score and systolic blood pressure were associated with higher cIMT (ß, 0.18 [95% CI, 0.05-0.31]); and (ß, 0.13 [95% CI, 0.00-0.25]; respectively) and PWV (ß, 0.20 [95% CI, 0.07-0.34]) and (ß, 0.13 [95% CI, 0.00-0.26]; respectively) at 8-year follow-up. Higher moderate-to-vigorous physical activity was associated with higher cIMT (ß, 0.25 [95% CI, 0.07-0.43]); yet lower PWV (ß, -0.25 [95% CI, -0.44 to -0.06]) at 8-year follow-up. Better cardiorespiratory fitness (ß, 0.29 [95% CI, 0.08-0.51]) and higher lean mass (ß, 0.51 [95% CI, 0.03-0.98]) were associated with higher cIMT after accounting for American Heart Association cardiovascular health score at 8-year follow-up., Conclusions: While our results suggest that higher cardiometabolic risk factors in childhood may exert unfavorable effects on arterial health during adolescence, we demonstrated the complexity of relationships between cardiovascular health metrics and arterial health indicators in childhood and adolescence. We found different associations of cardiovascular health metrics with cIMT and PWV in childhood and adolescence, calling for caution when interpreting the results of various cardiovascular risk factors with measures of arterial health, particularly in youth., Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01803776.
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- 2024
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43. Extending the SUSI peatland simulator to include dissolved organic carbon formation, transport and biodegradation - Proper water management reduces lateral carbon fluxes and improves carbon balance.
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Palviainen M, Pumpanen J, Mosquera V, Hasselquist EM, Laudon H, Ostonen I, Kull A, Wilson FR, Peltomaa E, Könönen M, Launiainen S, Peltola H, Ojala A, and Laurén A
- Subjects
- Soil chemistry, Wetlands, Environmental Monitoring, Carbon Dioxide analysis, Models, Theoretical, Finland, Sweden, Ecosystem, Carbon analysis, Carbon Cycle, Biodegradation, Environmental
- Abstract
Drainage intensity and forest management in peatlands affect carbon dioxide (CO
2 ) emissions to the atmosphere and export of dissolved organic carbon (DOC) to water courses. The peatland carbon (C) balance results from a complex network of ecosystem processes from where lateral C fluxes have typically been ignored. Here, we present a new version of the SUSI Peatland simulator, the first advanced process-based ecosystem model that compiles a full C balance in drained forested peatland including DOC formation, transport and biodegradation. SUSI considers site, stand and terrain characteristics as well as the interactions and feedbacks between ecosystem processes and offers novel ways to evaluate and mitigate adverse environmental impacts with thorough management planning. Here, we extended SUSI by designing and parameterizing a mass-balance based decomposition module (ESOM) based on literature findings and tested the ESOM performance against an independent dataset measured in the laboratory using peat columns collected from Finland, Estonia, Sweden and Ireland. ESOM predicted the CO2 emissions and changes in DOC concentrations with a reasonable accuracy for the peat columns. We applied the new SUSI for drained peatland sites and found that reducing the depth to which ditches are cleaned by 0.3 m decreased the annual DOC export by 34 (17 %), 29 (19 %) and 7 (5 %) kg ha-1 in Finland, Estonia and Sweden, respectively, using typical ditch spacing for these countries. Correspondingly, site annual C sink increased by 305, 409 and 32 kg ha-1 in Finland, Estonia and Sweden, respectively. Our results also indicated that terrain slope can markedly alter the water residence time and consequently DOC biodegradation and export to ditches. We conclude that DOC export can be decreased and site C sink increased by reducing the depth to which ditches are cleaned or by increasing the ditch spacing., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)- Published
- 2024
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44. Association of Hypertension With Early-Onset Cryptogenic Ischemic Stroke by the Presence of Patent Foramen Ovale: A Case-Control Study.
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Putaala J, von Sarnowski B, Schminke U, Busch R, Martinez-Majander N, Ylikotila P, Lautamäki R, Zedde M, Grimaldi T, Sarkanen T, Virtanen M, Ryliskiene K, Zakarkaite D, Tulkki L, Pirinen J, Licenik R, Ferdinand P, Oxley C, Kõrv J, Muda P, Pezzini A, Lombardi CM, Tsivgoulis G, Suihko S, Tolppanen H, Fonseca AC, Martínez-Sánchez P, Amaya Pascasio L, Yesilot N, Elitok A, Waje-Andreassen U, Saeed S, Redfors P, Bech-Hanssen O, Huhtakangas J, Hedman M, Jäkälä P, Sinisalo J, and Gerdts E
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- 2024
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45. Policy as normative influence? On the relationship between parental leave policy and social norms in gender division of childcare across 48 countries.
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Schindler S, Schuster C, Olsson MIT, Froehlich L, Hübner AK, Block K, Van Laar C, Schmader T, Meeussen L, van Grootel S, Croft A, Sun MS, Ainsaar M, Aarntzen L, Adamus M, Anderson J, Atkinson C, Avicenna M, Bąbel P, Barth M, Benson-Greenwald T, Maloku E, Berent J, Bergsieker HB, Biernat M, Birneanu A, Bodinaku B, Bosak J, Bosson J, Branković M, Burkauskas J, Čavojová V, Cheryan S, Choi E, Choi I, Contreras-Ibáñez CC, Coogan A, Danyliuk I, Dar-Nimrod I, Dasgupta N, de Lemus S, Devos T, Diab M, Diekman AB, Efremova M, Eisner L, Eller A, Erentaite R, Fedáková D, Franc R, Gartzia L, Gavreliuc A, Gavreliuc D, Gecaite-Stonciene J, Germano AL, Giovannelli I, Gismondi Diaz R, Gitikhmayeva L, Gizaw AM, Gjoneska B, González OM, González R, Grijalva ID, Güngör D, Gustafsson Sendén M, Hall W, Harb C, Hassan B, Hässler T, Hawi DR, Henningsen L, Hoppe A, Ishii K, Jakšić I, Jasini A, Jurkevičienė J, Kelmendi K, Kirby TA, Kitakaji Y, Kosakowska-Berezecka N, Kozytska I, Kulich C, Kundtová-Klocová E, Kunuroglu F, Aidy CL, Lee A, Lindqvist A, López-López W, Luzvinda L, Maricchiolo F, Martinot D, McNamara RA, Meister A, Melka TL, Mickuviene N, Miranda-Orrego MI, Mkamwa T, Morandini J, Morton T, Mrisho D, Nikitin J, Otten S, Pacilli MG, Page-Gould E, Perandrés-Gómez A, Pizarro J, Pop-Jordanova N, Pyrkosz-Pacyna J, Quta S, Ramis T, Rani N, Redersdorff S, Régner I, Renström EA, Rivera-Rodriguez A, Esmeralda RT, Ryabichenko T, Saab R, Sakata K, Samekin A, Sánchez-Pacheco T, Scheifele C, Schulmeyer MK, Sczesny S, Sirlopú D, Smith-Castro V, Soo K, Spaccatini F, Steele JR, Steffens MC, Sucic I, Vandello J, Velásquez-Díaz LM, Vink M, Vives E, Warkineh TZ, Žeželj I, Zhang X, Zhao X, Koc Y, Kocak ÖE, and Martiny SE
- Abstract
In the present work, we addressed the relationship between parental leave policies and social norms. Using a pre-registered, cross-national approach, we examined the relationship between parental leave policies and the perception of social norms for the gender division of childcare. In this study, 19,259 students (11,924 women) from 48 countries indicated the degree to which they believe childcare is (descriptive norm) and should be (prescriptive norm) equally divided among mothers and fathers. Policies were primarily operationalized as the existence of parental leave options in the respective country. The descriptive and prescriptive norms of equal division of childcare were stronger when parental leave was available in a country - also when controlling for potential confounding variables. Moreover, analyses of time since policy change suggested that policy change may initially affect prescriptive norms and then descriptive norms at a later point. However, due to the cross-sectional nature of the data, drawing causal inferences is difficult., (© 2024 British Psychological Society.)
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- 2024
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46. Phylogenomics and biogeography of sawflies and woodwasps (Hymenoptera, Symphyta).
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Wutke S, Blank SM, Boevé JL, Faircloth BC, Koch F, Linnen CR, Malm T, Niu G, Prous M, Schiff NM, Schmidt S, Taeger A, Vilhelmsen L, Wahlberg N, Wei M, and Nyman T
- Subjects
- Animals, Sequence Analysis, DNA, Bayes Theorem, Phylogeny, Hymenoptera genetics, Hymenoptera classification, Phylogeography
- Abstract
Phylogenomic approaches have recently helped elucidate various insect relationships, but large-scale comprehensive analyses on relationships within sawflies and woodwasps are still lacking. Here, we infer the relationships and long-term biogeographic history of these hymenopteran groups using a large dataset of 354 UCE loci collected from 385 species that represent all major lineages. Early Hymenoptera started diversifying during the Early Triassic ∼249 Ma and spread all over the ancient supercontinent Pangaea. We recovered Xyeloidea as a monophyletic sister group to other Hymenoptera and Pamphilioidea as sister to Unicalcarida. Within the diverse family Tenthredinidae, our taxonomically and geographically expanded taxon sampling highlights the non-monophyly of several traditionally defined subfamilies. In addition, the recent removal of Athalia and related genera from the Tenthredinidae into the separate family Athaliidae is supported. The deep historical biogeography of the group is characterised by independent dispersals and re-colonisations between the northern (Laurasia) and southern (Gondwana) palaeocontinents. The breakup of these landmasses led to ancient vicariance in several Gondwanan lineages, while interchange across the Northern Hemisphere has continued until the Recent. The little-studied African sawfly fauna is likewise a diverse mixture of groups with varying routes of colonization. Our results reveal interesting parallels in the evolution and biogeography of early hymenopterans and other ancient insect groups., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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47. Prospective multicenter study to validate the gastrointestinal dysfunction score (GIDS) in intensive care patients: Study protocol for Part A of the international GUTPHOS study.
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Kouw IWK, Melchers M, Mändul M, Arabi YM, Casaer MP, Cotoia A, Gunst J, Malbrain MLNG, Schaller SJ, Starkopf J, Sundström Rehal M, Reintam Blaser A, and van Zanten ARH
- Subjects
- Adult, Female, Humans, Male, Critical Care methods, Hospital Mortality, Length of Stay, Parenteral Nutrition, Prospective Studies, Reproducibility of Results, Severity of Illness Index, Multicenter Studies as Topic, Critical Illness, Gastrointestinal Diseases, Intensive Care Units
- Abstract
Background: While gastrointestinal (GI) dysfunction is commonly encountered among critically ill patients, a uniform prospectively validated scoring system is lacking. The present study aims to validate the recently developed Gastrointestinal Dysfunction Score (GIDS) in a multicenter, prospective cohort of consecutive adult patients admitted to intensive care units (ICU)., Methods: GUTPHOS is a prospective, multicenter, non-interventional cohort study in which at least 1400 consecutive adult patients (age ≥18 years) admitted to the ICU will be monitored daily for abdominal signs and symptoms of GI dysfunction. The previously developed GIDS constructed from these signs and symptoms will be tested in relation to mortality and duration of ICU dependency and parenteral nutrition (PN) dependency. Between January and June 2024, each participating clinical site will include 50-120 consecutive patients over an eight-week period. Study data will be collected in three phases: baseline data upon ICU admission, daily observations throughout a maximum of 7 days in ICU or until discharge, and a follow-up period of 90 days. The primary outcomes are 28- and 90-day all-cause mortality. Secondary outcomes include ICU and hospital mortality, ICU and hospital length of stay, days alive and free of ICU by day 28 and day 90, days alive and free of hospital by day 28 and day 90, and days alive and free of organ support and PN dependency by day 28., Discussion: The GUTPHOS study will be the first worldwide, multicenter, prospective, observational cohort study to validate the GIDS in adult patients admitted to ICUs against 28- and 90-day mortality. The availability of a validated tool will allow its use in interventional studies that are currently hindered by the lack of a validated measurement tool for GI dysfunction., Clinical Trial Registry: NCT05909722., Competing Interests: Declaration of competing interest IWKK received a Veni Fellowship (2024–2028) through the Dutch Research Council (NWO Talent Program). SJS received grants and non-financial support from Reactive Robotics GmbH (Munich, Germany), ASP GmbH (Attendorn, Germany), STIMIT AG (Biel, Switzerland), ESICM (Geneva, Switzerland), grants, personal fees, and non-financial support from Fresenius Kabi Deutschland GmbH (Bad Homburg, Germany), grants from the Innovationsfond of The Federal Joint Committee (G-BA), personal fees from Springer Verlag GmbH (Vienna, Austria) for educational purposes and Advanz Pharma GmbH (Bielefeld, Germany), non-financial support from national and international societies (and their congress organizers) in the field of anesthesiology and intensive care medicine, outside the submitted work. SJS holds stocks in small amounts from Alphabet Inc., Bayer AG, and Siemens AG; these holdings have not affected any decisions regarding his research or this study. ARHvZ reported receiving honoraria for advisory board meetings, lectures, research, and travel expenses from Abbott, AOP Pharma, Baxter, Cardinal Health, Danone-Nutricia, Fresenius Kabi, GE Healthcare, Medcaptain, Nestlé, PAION, and Rousselot. ARB received speaker or consulting fees from Nutricia and VIPUN Medical. JG is granted a senior clinical investigator fellowship by Research Foundation – Flanders (1842724N) and has obtained research funding through grants from KU Leuven (STG/23/032) and the European Society of Intensive Care Medicine (Fundamental Research Award 2022). MPC has obtained research funding by grants from Research Foundation Flanders, KU Leuven and Department for Innovation of the Flanders Government, and reported receiving consulting fees from Baxter and VIPUN. MLNGM reported receiving honoraria for advisory board meetings, lectures, research, and travel expenses from Getinge, Serenno Medical, Potrero Medical, Sentinel Medical, Baxter, BBraun, Becton Dickinson, ConvaTec, Spiegelberg, Medtronic, MedCaptain, and Holtech Medical, and PeerVoice. He holds stock options for Sentinel, Serenno and Potrero. The other authors declare no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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48. Prospective multicenter study to describe the prevalence, outcomes, and management of phosphate disorders in intensive care patients: Study protocol for part B of the international GUTPHOS study.
- Author
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Melchers M, Kouw IWK, Arabi YM, Casaer MP, Cotoia A, Gunst J, Malbrain MLNG, Schaller SJ, Starkopf J, Rehal MS, Blaser AR, and van Zanten ARH
- Subjects
- Humans, Prospective Studies, Prevalence, Critical Care, Critical Illness, Treatment Outcome, Female, Male, Adult, Intensive Care Units, Phosphates blood, Hyperphosphatemia, Hypophosphatemia epidemiology
- Abstract
Background: Aberrations in blood phosphate (Pi) levels, whether presenting as hypo- or hyperphosphatemia, appear to be associated with clinical complications and adverse outcomes in patients admitted to an intensive care unit (ICU). However, the prevalence of Pi disorders and the association with subsequent factors and organ failures leading to death in ICU patients are poorly described. Despite endeavors to understand the etiology and treatment of low Pi levels from systematic reviews and meta-analyses, the literature lacks comprehensive guidance for managing hypophosphatemia. Hyperphosphatemia, on the other hand, appears to be associated with higher mortality among critically ill patients, yet its prevalence among ICU patients, particularly following phosphate repletion, remains unknown. The present study aims to investigate the prevalence of Pi abnormalities upon ICU admission and their incidence during the first week of ICU stay, the factors associated with Pi alterations, and the effect of phosphate repletion on the normalization of Pi levels, and its associations with clinical outcomes., Methods: This multicentre, prospective, non-interventional cohort study will include at least 1000 consecutive adult ICU patients (≥18 years) as part B of the GUTPHOS study. Sites are eligible if an anticipated minimal inclusion of 50 eligible patients during eight weeks from January 2024 until June 2024 and daily phosphate measurements during the first seven days of ICU stay are expected. All consecutive adult patients admitted to a participating ICU during the recruitment period, lasting up to eight weeks, or up to 120 patients if enrollment reaches that limit earlier, will be included. Study parameters include study site characteristics, patient demographics, daily assessment of Pi levels, Pi-related treatment, feeding details, renal replacement therapy details, the incidence of refeeding-associated hypophosphatemia and administered medication (during the first seven calendar days of ICU stay). There will be a follow-up period of a maximum of 90 days to document 28- and 90-day all-cause mortality as the primary outcome. Multiple logistic regression will be used to assess independent associations with mortality in addition to Receiver Operating Characteristics curves to identify cut-off Pi values associated with mortality and overcorrection. Linear mixed models will be conducted to assess Pi treatment effects. Subgroup analyses will be performed based on Pi abnormalities observed during ICU admission, categorized as normo-, hypo-, hyper-, or mixed, along with its severity (mild, moderate, or severe)., Discussion: The GUTPHOS study will be the first multicentre, prospective observational cohort study to investigate the prevalence, management practices, and consequent outcomes associated with Pi abnormalities during the first week of ICU admission. Its results may bridge the current evidence gap in repletion protocols while establishing the groundwork for a subsequent randomized controlled trial., Clinical Trial Registry: NCT05909722., Competing Interests: Declaration of competing interest IWKK received a Veni Fellowship (2024–2028) through the Dutch Research Council (NWO Talent Program). SJS received grants and non-financial support from Reactive Robotics GmbH (Munich, Germany), ASP GmbH (Attendorn, Germany), STIMIT AG (Biel, Switzerland), ESICM (Geneva, Switzerland), grants, personal fees, and non-financial support from Fresenius Kabi Deutschland GmbH (Bad Homburg, Germany), grants from the Innovationsfond of The Federal Joint Committee (G-BA), personal fees from Springer Verlag GmbH (Vienna, Austria) for educational purposes and Advanz Pharma GmbH (Bielefeld, Germany), non-financial support from national and international societies (and their congress organizers) in the field of anesthesiology and intensive care medicine, outside the submitted work. SJS holds stocks in small amounts from Alphabet Inc., Bayer AG, and Siemens AG; these holdings have not affected any decisions regarding his research or this study. ARHvZ reported receiving honoraria for advisory board meetings, lectures, research, and travel expenses from Abbott, AOP Pharma, Baxter, Cardinal Health, Danone-Nutricia, Fresenius Kabi, GE Healthcare, Medcaptain, Nestlé, PAION, and Rousselot. ARB received speaker or consulting fees from Nutricia and VIPUN Medical and is holding a grant from Estonian Research Council (PRG1255). MPC has obtained research funding by grants from Research Foundation Flanders, KU Leuven and Department for Innovation of the Flanders Government, and reported receiving consulting fees from Baxter and VIPUN. MLNGM reported receiving honoraria for advisory board meetings, lectures, research, and travel expenses from Getinge, Serenno Medical, Potrero Medical, Sentinel Medical, Baxter, BBraun, Becton Dickinson, ConvaTec, Spiegelberg, Medtronic, MedCaptain, and Holtech Medical, and PeerVoice. He holds stock options for Sentinel, Serenno and Potrero. JG is granted a senior clinical investigator fellowship by Research Foundation – Flanders (1842724N), and has obtained research funding by grants from KU Leuven (STG/23/032) and the European Society of Intensive Care Medicine (Fundamental Research Award 2022). The other authors declare no competing interests., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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49. What do the pre-stimulus brain-process markers really mean vis-à-vis the NCC?: A commentary on "Beyond task response-Pre-stimulus activity modulates contents of consciousness" by Northoff, Zilio, and Zhang.
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Bachmann T
- Subjects
- Humans, Consciousness, Brain physiology
- Abstract
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: E-i-C of Consciousness and Cognition (an Elsevier journal). If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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- 2024
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50. Genetic modifiers and ascertainment drive variable expressivity of complex disorders.
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Jensen M, Smolen C, Tyryshkina A, Pizzo L, Banerjee D, Oetjens M, Shimelis H, Taylor CM, Pounraja VK, Song H, Rohan L, Huber E, El Khattabi L, van de Laar I, Tadros R, Bezzina C, van Slegtenhorst M, Kammeraad J, Prontera P, Caberg JH, Fraser H, Banka S, Van Dijck A, Schwartz C, Voorhoeve E, Callier P, Mosca-Boidron AL, Marle N, Lefebvre M, Pope K, Snell P, Boys A, Lockhart PJ, Ashfaq M, McCready E, Nowacyzk M, Castiglia L, Galesi O, Avola E, Mattina T, Fichera M, Bruccheri MG, Mandarà GML, Mari F, Privitera F, Longo I, Curró A, Renieri A, Keren B, Charles P, Cuinat S, Nizon M, Pichon O, Bénéteau C, Stoeva R, Martin-Coignard D, Blesson S, Le Caignec C, Mercier S, Vincent M, Martin C, Mannik K, Reymond A, Faivre L, Sistermans E, Kooy RF, Amor DJ, Romano C, Andrieux J, and Girirajan S
- Abstract
Variable expressivity of disease-associated variants implies a role for secondary variants that modify clinical features. We assessed the effects of modifier variants towards clinical outcomes of 2,252 individuals with primary variants. Among 132 families with the 16p12.1 deletion, distinct rare and common variant classes conferred risk for specific developmental features, including short tandem repeats for neurological defects and SNVs for microcephaly, while additional disease-associated variants conferred multiple genetic diagnoses. Within disease and population cohorts of 773 individuals with the 16p12.1 deletion, we found opposing effects of secondary variants towards clinical features across ascertainments. Additional analysis of 1,479 probands with other primary variants, such as 16p11.2 deletion and CHD8 variants, and 1,084 without primary variants, showed that phenotypic associations differed by primary variant context and were influenced by synergistic interactions between primary and secondary variants. Our study provides a paradigm to dissect the genomic architecture of complex disorders towards personalized treatment., Competing Interests: DECLARATION OF INTERESTS The authors declare no competing interests.
- Published
- 2024
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- View/download PDF
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