1,961 results on '"University of Porto, Portugal"'
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2. Home-Based Exercise Program During Neoadjuvant Treatment to Improve Fatigue and Quality of Life in Early HER2-Positive and Triple-Negative Breast Cancer Patients (HoPEx-Breast)
- Author
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Oncology Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), ICBAS-School of Medicine and Biomedical Sciences, University of Porto, Portugal, Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo António, Porto, Portugal, and Rita Carrilho Pichel, MD / PI
- Published
- 2025
3. Repository: 49 Methods and Assignments for Writing Urban Places
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Machado e Moura (ed), Carlos; Center for Studies in Architecture and Urbanism (CEAU), Faculty of Architecture, University of Porto, Portugal, Milián Bernal (ed), Dalia; School of Architecture, Faculty of the Built Environment, Tampere University, Finland, Restrepo Restrepo (ed), Esteban; Department of Arts and Representation Techniques, École Nationale Supérieure d’Architecture de Paris-La Villette, France, Havik (ed), Klaske; Department of Architecture, Faculty of Architecture and the Built Environment, Delft University of Technology, The Netherlands, Niculae (ed), Lorin; Department of Basics of Architectural Design, Faculty of Architecture, Ion Mincu University of Architecture and Urban Planning, Romania, Machado e Moura (ed), Carlos; Center for Studies in Architecture and Urbanism (CEAU), Faculty of Architecture, University of Porto, Portugal, Milián Bernal (ed), Dalia; School of Architecture, Faculty of the Built Environment, Tampere University, Finland, Restrepo Restrepo (ed), Esteban; Department of Arts and Representation Techniques, École Nationale Supérieure d’Architecture de Paris-La Villette, France, Havik (ed), Klaske; Department of Architecture, Faculty of Architecture and the Built Environment, Delft University of Technology, The Netherlands, and Niculae (ed), Lorin; Department of Basics of Architectural Design, Faculty of Architecture, Ion Mincu University of Architecture and Urban Planning, Romania
- Abstract
‘Repository. 49 Methods and Assignments for Writing Urban Places’ offers a set of methods and assignments intended to stimulate new approaches in architecture, urban studies, and other fields of spatial development and to invite creative, often embodied, and sometimes playful engagements with the material and immaterial dimensions of urban places. This Repository collects 49 methods, defined here as systematic procedures, techniques and ways of acting, to explore, examine and discover urban places. Each method is described in a brief text and followed by a direct short assignment. Presented as a clear set of instructions, the assignment encourages and guides the reader to fully or partially explore and employ the method.
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- 2024
4. Study protocol - Determinants of Treatment Success in Chronic Obstructive Pulmonary Disease
- Author
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Araújo, António Duarte, Respiratory Department, H. Sª Oliveira, Guimarães, Portugal. - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. - ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal., Hespanhol, Venceslau Pinto, Department of Pneumology, Centro Hospitalar de S. João, Faculty of Medicine (FMUP), University of Porto, Portugal, Correia-de-Sousa, Jaime, and Community Health, School of Medicine, University of Minho, Braga, Portugal
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COPD ,study protocol ,treatment success - Published
- 2017
5. Monitoring Porto 2006-2008
- Author
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Arenas Parra, Francisco, Sousa Pinto, Isabel, and Interdisciplinary Centre For Marine And Environmental Research (Porto)-University Of Porto, Portugal
- Published
- 2012
- Full Text
- View/download PDF
6. Stades et niveaux de traitement de l’information visuelle
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Invited Seminar (May 1989: University of Porto, Portugal), Kolinsky, Régine, Invited Seminar (May 1989: University of Porto, Portugal), and Kolinsky, Régine
- Abstract
info:eu-repo/semantics/nonPublished
- Published
- 1989
7. Does exergaming drive future physical activity and sport intentions?
- Author
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Pooya Soltani, João Paulo Vilas-Boas, Pedro Figueiredo, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Porto Biomechanics Laboratory (LABIOMEP), University of Porto, Portugal, Department of Physical Education and Sport Sciences, School of Education and Psychology, Shiraz University, Iran, Assistive Technologies Innovation Centre (ATiC), University of Wales Trinity Saint David, UK, Portuguese Football School, Portuguese Football Federation, Portugal, Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University Institute of Maia, ISMAI, Portugal, Universidade do Porto = University of Porto, Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), and Universidade do Porto
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Pleasure ,Applied psychology ,Physical activity ,Affect (psychology) ,enjoyment ,03 medical and health sciences ,0302 clinical medicine ,Humans ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,030212 general & internal medicine ,Applied Psychology ,exercise ,business.industry ,ComputingMilieux_PERSONALCOMPUTING ,Usability ,030229 sport sciences ,game experience ,system usability ,Video Games ,intention ,[INFO.EIAH]Computer Science [cs]/Technology for Human Learning ,Psychology ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Sports - Abstract
We studied how usability and playability of sport exergames affect future intentions of participation in physical activity or actual sport. We employed questionnaires to measure participants' enjoyment, usability, game-experience, and future intentions of physical activity and real sport. We compared the outcomes based on players' gender, previous real-swimming, and exergame experience. Psychological parameters were not different between groups but players without exergame experience enjoyed the game more. Physical activity intentions increased for all participants but not swimming intentions. The limitations of current gaming systems and their effects on players' gaming experience and intentions are discussed. info:eu-repo/semantics/publishedVersion
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- 2020
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- View/download PDF
8. Deeply virtual Compton scattering from gauge/gravity duality
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Djuric, Marko [University of Porto (Portugal)]
- Published
- 2013
- Full Text
- View/download PDF
9. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
- Author
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Emma Nichols, Jaimie D Steinmetz, Stein Emil Vollset, Kai Fukutaki, Julian Chalek, Foad Abd-Allah, Amir Abdoli, Ahmed Abualhasan, Eman Abu-Gharbieh, Tayyaba Tayyaba Akram, Hanadi Al Hamad, Fares Alahdab, Fahad Mashhour Alanezi, Vahid Alipour, Sami Almustanyir, Hubert Amu, Iman Ansari, Jalal Arabloo, Tahira Ashraf, Thomas Astell-Burt, Getinet Ayano, Jose L Ayuso-Mateos, Atif Amin Baig, Anthony Barnett, Amadou Barrow, Bernhard T Baune, Yannick Béjot, Woldesellassie M Mequanint Bezabhe, Yihienew Mequanint Bezabih, Akshaya Srikanth Bhagavathula, Sonu Bhaskar, Krittika Bhattacharyya, Ali Bijani, Atanu Biswas, Srinivasa Rao Bolla, Archith Boloor, Carol Brayne, Hermann Brenner, Katrin Burkart, Richard A Burns, Luis Alberto Cámera, Chao Cao, Felix Carvalho, Luis F S Castro-de-Araujo, Ferrán Catalá-López, Ester Cerin, Prachi P Chavan, Nicolas Cherbuin, Dinh-Toi Chu, Vera Marisa Costa, Rosa A S Couto, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Vanessa De la Cruz-Góngora, Deepak Dhamnetiya, Diana Dias da Silva, Daniel Diaz, Abdel Douiri, David Edvardsson, Michael Ekholuenetale, Iman El Sayed, Shaimaa I El-Jaafary, Khalil Eskandari, Sharareh Eskandarieh, Saman Esmaeilnejad, Jawad Fares, Andre Faro, Umar Farooque, Valery L Feigin, Xiaoqi Feng, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Pietro Ferrara, Irina Filip, Howard Fillit, Florian Fischer, Shilpa Gaidhane, Lucia Galluzzo, Ahmad Ghashghaee, Nermin Ghith, Alessandro Gialluisi, Syed Amir Gilani, Ionela-Roxana Glavan, Elena V Gnedovskaya, Mahaveer Golechha, Rajeev Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Mohammad Rifat Haider, Brian J Hall, Samer Hamidi, Asif Hanif, Graeme J Hankey, Shafiul Haque, Risky Kusuma Hartono, Ahmed I Hasaballah, M Tasdik Hasan, Amr Hassan, Simon I Hay, Khezar Hayat, Mohamed I Hegazy, Golnaz Heidari, Reza Heidari-Soureshjani, Claudiu Herteliu, Mowafa Househ, Rabia Hussain, Bing-Fang Hwang, Licia Iacoviello, Ivo Iavicoli, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Seyed Sina Naghibi Irvani, Hiroyasu Iso, Masao Iwagami, Roxana Jabbarinejad, Louis Jacob, Vardhmaan Jain, Sathish Kumar Jayapal, Ranil Jayawardena, Ravi Prakash Jha, Jost B Jonas, Nitin Joseph, Rizwan Kalani, Amit Kandel, Himal Kandel, André Karch, Ayele Semachew Kasa, Gizat M Kassie, Pedram Keshavarz, Moien AB Khan, Mahalaqua Nazli Khatib, Tawfik Ahmed Muthafer Khoja, Jagdish Khubchandani, Min Seo Kim, Yun Jin Kim, Adnan Kisa, Sezer Kisa, Mika Kivimäki, Walter J Koroshetz, Ai Koyanagi, G Anil Kumar, Manasi Kumar, Hassan Mehmood Lak, Matilde Leonardi, Bingyu Li, Stephen S Lim, Xuefeng Liu, Yuewei Liu, Giancarlo Logroscino, Stefan Lorkowski, Giancarlo Lucchetti, Ricardo Lutzky Saute, Francesca Giulia Magnani, Ahmad Azam Malik, João Massano, Man Mohan Mehndiratta, Ritesh G Menezes, Atte Meretoja, Bahram Mohajer, Norlinah Mohamed Ibrahim, Yousef Mohammad, Arif Mohammed, Ali H Mokdad, Stefania Mondello, Mohammad Ali Ali Moni, Md Moniruzzaman, Tilahun Belete Mossie, Gabriele Nagel, Muhammad Naveed, Vinod C Nayak, Sandhya Neupane Kandel, Trang Huyen Nguyen, Bogdan Oancea, Nikita Otstavnov, Stanislav S Otstavnov, Mayowa O Owolabi, Songhomitra Panda-Jonas, Fatemeh Pashazadeh Kan, Maja Pasovic, Urvish K Patel, Mona Pathak, Mario F P Peres, Arokiasamy Perianayagam, Carrie B Peterson, Michael R Phillips, Marina Pinheiro, Michael A Piradov, Constance Dimity Pond, Michele H Potashman, Faheem Hyder Pottoo, Sergio I Prada, Amir Radfar, Alberto Raggi, Fakher Rahim, Mosiur Rahman, Pradhum Ram, Priyanga Ranasinghe, David Laith Rawaf, Salman Rawaf, Nima Rezaei, Aziz Rezapour, Stephen R Robinson, Michele Romoli, Gholamreza Roshandel, Ramesh Sahathevan, Amirhossein Sahebkar, Mohammad Ali Sahraian, Brijesh Sathian, Davide Sattin, Monika Sawhney, Mete Saylan, Silvia Schiavolin, Allen Seylani, Feng Sha, Masood Ali Shaikh, KS Shaji, Mohammed Shannawaz, Jeevan K Shetty, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Diego Augusto Santos Silva, João Pedro Silva, Renata Silva, Jasvinder A Singh, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Amanda E Smith, Sergey Soshnikov, Emma Elizabeth Spurlock, Dan J Stein, Jing Sun, Rafael Tabarés-Seisdedos, Bhaskar Thakur, Binod Timalsina, Marcos Roberto Tovani-Palone, Bach Xuan Tran, Gebiyaw Wudie Tsegaye, Sahel Valadan Tahbaz, Pascual R Valdez, Narayanaswamy Venketasubramanian, Vasily Vlassov, Giang Thu Vu, Linh Gia Vu, Yuan-Pang Wang, Anders Wimo, Andrea Sylvia Winkler, Lalit Yadav, Seyed Hossein Yahyazadeh Jabbari, Kazumasa Yamagishi, Lin Yang, Yuichiro Yano, Naohiro Yonemoto, Chuanhua Yu, Ismaeel Yunusa, Siddhesh Zadey, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Zhi-Jiang Zhang, Christopher J L Murray, Theo Vos, Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T. T., Al Hamad, H., Alahdab, F., Alanezi, F. M., Alipour, V., Almustanyir, S., Amu, H., Ansari, I., Arabloo, J., Ashraf, T., Astell-Burt, T., Ayano, G., Ayuso-Mateos, J. L., Baig, A. A., Barnett, A., Barrow, A., Baune, B. T., Bejot, Y., Bezabhe, W. M. M., Bezabih, Y. M., Bhagavathula, A. S., Bhaskar, S., Bhattacharyya, K., Bijani, A., Biswas, A., Bolla, S. R., Boloor, A., Brayne, C., Brenner, H., Burkart, K., Burns, R. A., Camera, L. A., Cao, C., Carvalho, F., Castro-de-Araujo, L. F. S., Catala-Lopez, F., Cerin, E., Chavan, P. P., Cherbuin, N., Chu, D. -T., Costa, V. M., Couto, R. A. S., Dadras, O., Dai, X., Dandona, L., Dandona, R., De la Cruz-Gongora, V., Dhamnetiya, D., Dias da Silva, D., Diaz, D., Douiri, A., Edvardsson, D., Ekholuenetale, M., El Sayed, I., El-Jaafary, S. I., Eskandari, K., Eskandarieh, S., Esmaeilnejad, S., Fares, J., Faro, A., Farooque, U., Feigin, V. L., Feng, X., Fereshtehnejad, S. -M., Fernandes, E., Ferrara, P., Filip, I., Fillit, H., Fischer, F., Gaidhane, S., Galluzzo, L., Ghashghaee, A., Ghith, N., Gialluisi, A., Gilani, S. A., Glavan, I. -R., Gnedovskaya, E. V., Golechha, M., Gupta, R., Gupta, V. B., Gupta, V. K., Haider, M. R., Hall, B. J., Hamidi, S., Hanif, A., Hankey, G. J., Haque, S., Hartono, R. K., Hasaballah, A. I., Hasan, M. T., Hassan, A., Hay, S. I., Hayat, K., Hegazy, M. I., Heidari, G., Heidari-Soureshjani, R., Herteliu, C., Househ, M., Hussain, R., Hwang, B. -F., Iacoviello, L., Iavicoli, I., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Irvani, S. S. N., Iso, H., Iwagami, M., Jabbarinejad, R., Jacob, L., Jain, V., Jayapal, S. K., Jayawardena, R., Jha, R. P., Jonas, J. B., Joseph, N., Kalani, R., Kandel, A., Kandel, H., Karch, A., Kasa, A. S., Kassie, G. M., Keshavarz, P., Khan, M. A., Khatib, M. N., Khoja, T. A. M., Khubchandani, J., Kim, M. S., Kim, Y. J., Kisa, A., Kisa, S., Kivimaki, M., Koroshetz, W. J., Koyanagi, A., Kumar, G. A., Kumar, M., Lak, H. M., Leonardi, M., Li, B., Lim, S. S., Liu, X., Liu, Y., Logroscino, G., Lorkowski, S., Lucchetti, G., Lutzky Saute, R., Magnani, F. G., Malik, A. A., Massano, J., Mehndiratta, M. M., Menezes, R. G., Meretoja, A., Mohajer, B., Mohamed Ibrahim, N., Mohammad, Y., Mohammed, A., Mokdad, A. H., Mondello, S., Moni, M. A. A., Moniruzzaman, M., Mossie, T. B., Nagel, G., Naveed, M., Nayak, V. C., Neupane Kandel, S., Nguyen, T. H., Oancea, B., Otstavnov, N., Otstavnov, S. S., Owolabi, M. O., Panda-Jonas, S., Pashazadeh Kan, F., Pasovic, M., Patel, U. K., Pathak, M., Peres, M. F. P., Perianayagam, A., Peterson, C. B., Phillips, M. R., Pinheiro, M., Piradov, M. A., Pond, C. D., Potashman, M. H., Pottoo, F. H., Prada, S. I., Radfar, A., Raggi, A., Rahim, F., Rahman, M., Ram, P., Ranasinghe, P., Rawaf, D. L., Rawaf, S., Rezaei, N., Rezapour, A., Robinson, S. R., Romoli, M., Roshandel, G., Sahathevan, R., Sahebkar, A., Sahraian, M. A., Sathian, B., Sattin, D., Sawhney, M., Saylan, M., Schiavolin, S., Seylani, A., Sha, F., Shaikh, M. A., Shaji, K. S., Shannawaz, M., Shetty, J. K., Shigematsu, M., Shin, J. I., Shiri, R., Silva, D. A. S., Silva, J. P., Silva, R., Singh, J. A., Skryabin, V. Y., Skryabina, A. A., Smith, A. E., Soshnikov, S., Spurlock, E. E., Stein, D. J., Sun, J., Tabares-Seisdedos, R., Thakur, B., Timalsina, B., Tovani-Palone, M. R., Tran, B. X., Tsegaye, G. W., Valadan Tahbaz, S., Valdez, P. R., Venketasubramanian, N., Vlassov, V., Vu, G. T., Vu, L. G., Wang, Y. -P., Wimo, A., Winkler, A. S., Yadav, L., Yahyazadeh Jabbari, S. H., Yamagishi, K., Yang, L., Yano, Y., Yonemoto, N., Yu, C., Yunusa, I., Zadey, S., Zastrozhin, M. S., Zastrozhina, A., Zhang, Z. -J., Murray, C. J. L., Vos, T., Department of Public Health, Clinicum, Helsinki University Hospital Area, Bill & Melinda Gates Foundation, University of Porto (Portugal), Medical Research Council (Reino Unido), Fundação para a Ciência e Tecnologia (Portugal), King College London, University College London Hospitals NHS Foundation Trust, NIHR - Oxford Biomedical Research Centre (Reino Unido), Novo Nordisk Foundation, National Health and Medical Research Council (Australia), Jazan University (Arabia Saudí), Romanian National Authority for Scientific Research and Innovation, Xiamen University Malaysia (Malasia), Wellcome Trust, Fogarty International Center (Estados Unidos), Federal Ministry of Education & Research (Alemania), Ministero della Salute (Italia), Coordenação de Aperfeicoamento de Pessoal de Nível Superior (Brasil), Nichols, E, D Steinmetz, J, Emil Vollset, S, Fukutaki, K, Chalek, J, Abd-Allah, F, Abdoli, A, Abualhasan, A, Abu-Gharbieh, E, Tayyaba Akram, T, Al Hamad, H, Alahdab, F, Mashhour Alanezi, F, Alipour, V, Almustanyir, S, Amu, H, Ansari, I, Arabloo, J, Ashraf, T, Astell-Burt, T, Ayano, G, L Ayuso-Mateos, J, Amin Baig, A, Barnett, A, Barrow, A, T Baune, B, Béjot, Y, M Mequanint Bezabhe, W, Mequanint Bezabih, Y, Srikanth Bhagavathula, A, Bhaskar, S, Bhattacharyya, K, Bijani, A, Biswas, A, Rao Bolla, S, Boloor, A, Brayne, C, Brenner, H, Burkart, K, A Burns, R, Alberto Cámera, L, Cao, C, Carvalho, F, S Castro-de-Araujo, L, Catalá-López, F, Cerin, E, P Chavan, P, Cherbuin, N, Chu, D, Marisa Costa, V, S Couto, R, Dadras, O, Dai, X, Dandona, L, Dandona, R, De la Cruz-Góngora, V, Dhamnetiya, D, Dias da Silva, D, Diaz, D, Douiri, A, Edvardsson, D, Ekholuenetale, M, El Sayed, I, I El-Jaafary, S, Eskandari, K, Eskandarieh, S, Esmaeilnejad, S, Fares, J, Faro, A, Farooque, U, L Feigin, V, Feng, X, Fereshtehnejad, S, Fernandes, E, Ferrara, P, Filip, I, Fillit, H, Fischer, F, Gaidhane, S, Galluzzo, L, Ghashghaee, A, Ghith, N, Gialluisi, A, Amir Gilani, S, Glăvan, I, V Gnedovskaya, E, Golechha, M, Gupta, R, Bala Gupta, V, Kumar Gupta, V, Rifat Haider, M, J Hall, B, Hamidi, S, Hanif, A, J Hankey, G, Haque, S, Kusuma Hartono, R, I Hasaballah, A, Tasdik Hasan, M, Hassan, A, I Hay, S, Hayat, K, I Hegazy, M, Heidari, G, Heidari-Soureshjani, R, Herteliu, C, Househ, M, Hussain, R, Hwang, B, Iacoviello, L, Iavicoli, I, Stephen Ilesanmi, O, M Ilic, I, D Ilic, M, Sina Naghibi Irvani, S, Iso, H, Iwagami, M, Jabbarinejad, R, Jacob, L, Jain, V, Kumar Jayapal, S, Jayawardena, R, Prakash Jha, R, B Jonas, J, Joseph, N, Kalani, R, Kandel, A, Kandel, H, Karch, A, Semachew Kasa, A, M Kassie, G, Keshavarz, P, B Khan, M, Nazli Khatib, M, Ahmed Muthafer Khoja, T, Khubchandani, J, Seo Kim, M, Jin Kim, Y, Kisa, A, Kisa, S, Kivimäki, M, J Koroshetz, W, Koyanagi, A, Anil Kumar, G, Kumar, M, Mehmood Lak, H, Leonardi, M, Li, B, S Lim, S, Liu, X, Liu, Y, Logroscino, G, Lorkowski, S, Lucchetti, G, Lutzky Saute, R, Giulia Magnani, F, Azam Malik, A, Massano, J, Mohan Mehndiratta, M, G Menezes, R, Meretoja, A, Mohajer, B, Mohamed Ibrahim, N, Mohammad, Y, Mohammed, A, H Mokdad, A, Mondello, S, Ali Moni, M, Moniruzzaman, M, Belete Mossie, T, Nagel, G, Naveed, M, C Nayak, V, Neupane Kandel, S, Huyen Nguyen, T, Oancea, B, Otstavnov, N, S Otstavnov, S, O Owolabi, M, Panda-Jonas, S, Pashazadeh Kan, F, Pasovic, M, K Patel, U, Pathak, M, P Peres, M, Perianayagam, A, B Peterson, C, R Phillips, M, Pinheiro, M, A Piradov, M, Dimity Pond, C, H Potashman, M, Hyder Pottoo, F, I Prada, S, Radfar, A, Raggi, A, Rahim, F, Rahman, M, Ram, P, Ranasinghe, P, Laith Rawaf, D, Rawaf, S, Rezaei, N, Rezapour, A, R Robinson, S, Romoli, M, Roshandel, G, Sahathevan, R, Sahebkar, A, Ali Sahraian, M, Sathian, B, Sattin, D, Sawhney, M, Saylan, M, Schiavolin, S, Seylani, A, Sha, F, Ali Shaikh, M, S Shaji, K, Shannawaz, M, K Shetty, J, Shigematsu, M, Il Shin, J, Shiri, R, Augusto Santos Silva, D, Pedro Silva, J, Silva, R, A Singh, J, Yurievich Skryabin, V, Aleksandrovna Skryabina, A, E Smith, A, Soshnikov, S, Elizabeth Spurlock, E, J Stein, D, Sun, J, Tabarés-Seisdedos, R, Thakur, B, Timalsina, B, Roberto Tovani-Palone, M, Xuan Tran, B, Wudie Tsegaye, G, Valadan Tahbaz, S, R Valdez, P, Venketasubramanian, N, Vlassov, V, Thu Vu, G, Gia Vu, L, Wang, Y, Wimo, A, Sylvia Winkler, A, Yadav, L, Hossein Yahyazadeh Jabbari, S, Yamagishi, K, Yang, L, Yano, Y, Yonemoto, N, Yu, C, Yunusa, I, Zadey, S, Sergeevich Zastrozhin, M, Zastrozhina, A, Zhang, Z, L Murray, C, and Vos, T
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Blood Glucose ,EUROPE ,Sociodemographic Factors ,Prevalence forecasts ,Population Dynamics ,UNITED-STATES ,DIAGNOSIS ,Global Health ,Body Mass Index ,Global Burden of Disease ,SDG 3 - Good Health and Well-being ,Risk Factors ,SYSTEMATIC ANALYSIS ,Humans ,METAANALYSIS ,Public, Environmental & Occupational Health ,RISK ,Population ageing ,Public health ,Population Dynamic ,Sociodemographic Factor ,Science & Technology ,Risk Factor ,Smoking ,Public Health, Environmental and Occupational Health ,Dementia forecasts ,Educational Statu ,TRENDS ,3142 Public health care science, environmental and occupational health ,ALZHEIMERS-DISEASE ,INSIGHTS ,Educational Status ,Dementia ,Public aspects of medicine ,RA1-1270 ,Life Sciences & Biomedicine ,MIXED BRAIN PATHOLOGIES ,MIDLIFE ,Human - Abstract
Background: Given the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study aimed to improve on previous forecasts of dementia prevalence by producing country-level estimates and incorporating information on selected risk factors. Methods: We forecasted the prevalence of dementia attributable to the three dementia risk factors included in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 (high body-mass index, high fasting plasma glucose, and smoking) from 2019 to 2050, using relative risks and forecasted risk factor prevalence to predict GBD risk-attributable prevalence in 2050 globally and by world region and country. Using linear regression models with education included as an additional predictor, we then forecasted the prevalence of dementia not attributable to GBD risks. To assess the relative contribution of future trends in GBD risk factors, education, population growth, and population ageing, we did a decomposition analysis. Findings: We estimated that the number of people with dementia would increase from 57·4 (95% uncertainty interval 50·4-65·1) million cases globally in 2019 to 152·8 (130·8-175·9) million cases in 2050. Despite large increases in the projected number of people living with dementia, age-standardised both-sex prevalence remained stable between 2019 and 2050 (global percentage change of 0·1% [-7·5 to 10·8]). We estimated that there were more women with dementia than men with dementia globally in 2019 (female-to-male ratio of 1·69 [1·64-1·73]), and we expect this pattern to continue to 2050 (female-to-male ratio of 1·67 [1·52-1·85]). There was geographical heterogeneity in the projected increases across countries and regions, with the smallest percentage changes in the number of projected dementia cases in high-income Asia Pacific (53% [41-67]) and western Europe (74% [58-90]), and the largest in north Africa and the Middle East (367% [329-403]) and eastern sub-Saharan Africa (357% [323-395]). Projected increases in cases could largely be attributed to population growth and population ageing, although their relative importance varied by world region, with population growth contributing most to the increases in sub-Saharan Africa and population ageing contributing most to the increases in east Asia. Interpretation: Growth in the number of individuals living with dementia underscores the need for public health planning efforts and policy to address the needs of this group. Country-level estimates can be used to inform national planning efforts and decisions. Multifaceted approaches, including scaling up interventions to address modifiable risk factors and investing in research on biological mechanisms, will be key in addressing the expected increases in the number of individuals affected by dementia. F Carvalho and E F Fernandes acknowledge support from the University of Porto (UID/MULTI/04378/2019 and UID/QUI/50006/2019 with funding from FCT/MCTES through national funds). L F S Castro-de-Araujo acknowledges support from the Medical Research Council (London; grant number MC_PC_MR/T03355X/1). V M Costa acknowledges her grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória (DL57/2016/CP1334/CT0006). A Douiri acknowledges support from the NIHR Applied Research Collaboration (ARC) South London at King’s College Hospital NHS Foundation Trust and the Royal College of Physicians, as well as the support from the NIHR Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. N Ghith acknowledges her salary as a postdoc is covered by a grant to her research group provided by Novo Nordisk Foundation. V K Gupta and V B Gupta acknowledge funding support from National Health and Medical Research Council (NHMRC), Australia. S Haque acknowledges support from Jazan University, Saudi Arabia, for providing access to the Saudi Digital Library for this study. C Herteliu is partially supported by a grant of the Romanian National Authority for Scientific Research and Innovation (CNDS-UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0084). Y J Kim was supported by the Research Management Centre, Xiamen University, Malaysia (No. XMUMRF/2020-C6/ITCM/0004). M Kivimäki was supported by the MRC (S011676) and the Wellcome Trust (221854/Z/20/Z). M Kumar acknowledges support from Fogarty International Center (K43 TW010716-04). S Lorkowski acknowledges institutional support from the Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig (Germany; German Federal Ministry of Education and Research, grant agreement number 01EA1808A). S Mondello was supported by the Italian Ministry of Health (GR-2013-02354960). A Raggi acknowledges support from a grant from the Italian Ministry of Health (Ricerca Corrente, Fondazione Istituto Neurologico C. Besta, Linea – Outcome Research: dagli Indicatori alle Raccomandazioni Cliniche). D A S Silva acknowledges support from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brasil (CAPES; Finance Code 001 / CAPES-PRINT). J P Silva acknowledges support from the Applied Molecular Biosciences Unit (UCIBIO; grant number UIDB/04378/2020), supported through Portuguese national funds via FCT/MCTES. Sí
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- 2021
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10. Dynamic off-centering of Cr3+ ions and short-range magneto-electric clusters in CdCr2S4
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Araujo, Joao [University of Porto, Portugal]
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- 2012
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11. Understanding the role played by Fe on the tuning of magnetocaloric effect in Tb5Si2Ge2
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Araujo, Joao [University of Porto, Portugal]
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- 2011
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12. Index integral representations for connection between cartesian, cylindrical, and spheroidal systems
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Yakubovich, Semyon [University of Porto, Portugal]
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- 2011
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13. The Influence of Virtual Reality Head-Mounted Displays on Balance Outcomes and Training Paradigms: A Systematic Review
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Pooya Soltani, Renato Andrade, Centre for the Analysis of Motion, Entertainment Research and Applications (CAMERA), Department of Computer Science, Department of Health, University of Bath (CAMERA), Department of Physical Education and Sport Sciences, School of Education and Psychology, Shiraz University, and Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Porto Biomechanics Laboratory (LABIOMEP), University of Porto, Portugal
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medicine.medical_specialty ,[SDV]Life Sciences [q-bio] ,Posture ,Psychological intervention ,Scopus ,Somatosensory ,Optical head-mounted display ,02 engineering and technology ,Review ,Virtual reality ,somatosensory ,[SHS]Humanities and Social Sciences ,03 medical and health sciences ,lcsh:GV557-1198.995 ,0302 clinical medicine ,Physical medicine and rehabilitation ,head-mounted display (HMD) ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,gender ,[INFO]Computer Science [cs] ,Head-mounted display ,posture (MeSH) ,Reliability (statistics) ,ComputingMilieux_MISCELLANEOUS ,older adults ,Balance (ability) ,lcsh:Sports ,vestibular ,business.industry ,020207 software engineering ,Usability ,balance ,Vestibular ,Sports and Active Living ,visual ,Visual ,Psychology ,business ,030217 neurology & neurosurgery ,Fall prevention - Abstract
Background: Falls are the leading causes of (non)fatal injuries in older adults. Recent research has developed interventions that aim to improve balance in older adults using virtual reality (VR).Purpose: We aimed to investigate the validity, reliability, safety, feasibility, and efficacy of head mounted display (HMD) systems for assessing and training balance in older adults.Methods: We searched EBSCOhost, Scopus, Web of Science, and PubMed databases until 1 September 2020 to find studies that used HMD systems for assessing or training balance. The methodological quality was assessed using a modified version of Downs and Black. We also appraised the risk of bias using Risk of Bias Assessment tool for Non-randomized Studies (RoBANS).Results: A total of 19 articles (637 participants) were included for review. Despite heterogenous age ranges and clinical conditions across studies, VR HMD systems were valid to assess balance and could be useful for fall prevention and for improving postural control and gait patterns. These systems also have the capacity to differentiate healthy and balance-impaired individuals. During VR versions of traditional balance tests, older adults generally acquire a cautious behavior and take more time to complete the tasks.Conclusion: VR HMD systems can offer ecologically valid scenarios to assess and train functional balance and can be used alone or in addition to other interventions. New norms and protocols should be defined according to participants' age, health status, and severity of their illness when using VR HMD systems for balance assessment and training. For safe and feasible training, attention must be given to display type, VR elements and scenarios, duration of exposure, and system usability. Due to high risk of bias and overall poor quality of the studies, further research is needed on the effectiveness of HMD VR training in older adults.
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- 2021
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14. On the orthogonality of the MacDonald s functions
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Yakubovich, Semyon [University of Porto, Portugal]
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- 2009
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15. Allies of the Order: Guilt-Projecting Witticism and Moral Discredit through Fantastic Non-Human Appearances Referring to Religious Others
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Maria Vittoria Spissu, Michael Conrad, University of Zurich (Switzerland), Luís Ferro, Faculty of Architecture from the University of Porto (Portugal), Borja Franco Llopis, Universidad Nacional de Educación a Distancia (UNED), Madrid (Spain), Rubén Gregori, University of Valencia (Spain), Alessandra Mascia, University of Fribourg (Switzerland), April L. Najjaj, Texas A&M University – San Antonio (United States of America), Maria Portmann, University of Zurich / State of Valais (Switzerland), Catherine Schaller, Perret University of Fribourg (Switzerland), Maria Portmann, and Maria Vittoria Spissu
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Alterità, manoscritti miniati, marginalia, crociate, predicazione, propaganda religiosa, ebrei, musulmani - Abstract
Il saggio presenta una ricerca effettuata sulle comparse di figure dissonanti, fantastiche, mostruose, nelle pagine dei libri miniati fiamminghi e inglesi, comparandone l'ideazione con quella delle sculture aggettanti, in chiese e edifici pubblici, specie del mondo iberico, ugualmente contraddistinte da un aspetto ibrido e perturbante, lungo le vie dei pellegrinaggi e della predicazione. Lo studio incrocia l'analisi stilistica e compositiva con la letteratura mistica, moraleggiante e apocalittica, con i trattati spirituali e gli scritti, relativi alle apologie delle crociate, per identificare la connessione tra attributi e elementi grotteschi e che rimandano al mondo animale e difetti fisici e morali, riferiti in maniera combinatoria a ebrei e musulmani (ma anche ad abitanti immaginari di paesi remoti e altri mondi) tra Medioevo e prima età moderna. Lo studio infine riflette sulla politica delle immagini, legata alla raffigurazione della marginalità (religiosa e sociale) tra meraviglia, satira e discredito, in relazione con le vicende storiche che hanno interessato la raffigurazione dell'altro in Europa, in immagini di propaganda e in consonanti proiezioni appartenenti alla devozione privata. Sottoposto a doppio referaggio cieco. The essay reconsiders mixed anthropomorphic, mythological and animal figures that were depicted on the margins of French and English illuminated manuscripts or sculpted in Spanish Romanesque churches. Taking in consideration the state of research that shows that physical troubles and moral disorders were considered together, the author reconsiders with an interdisciplinary methodology, the questions of the upside-down world and the monsters. It is an anthropological and visual analysis showing that such images were not only used as apotropaic items, but also associated with non-Christian cultures, in order to criticize the potential social and religious disorder caused by the Jews and Muslims at that time. The essay compares illustrations with medieval texts, either religious or profane, in order to underline the context of the creation of such figures and their use within the propaganda for the Crusades at that time. It also reconsiders the question of the visual construction of a Christian ‘self’ vs. the diversity of the representations of ‘otherness’. The study has been extended to include an analysis of physical deformity and anatomical diseases, using as example animals and moral pollution of the ‘other’. Such a context had a great impact on the ‘disguised’ or ‘erased’ image of the Jews, the Muslims and the Black people in medieval and early modern art, on the margins of manuscripts and in religious architecture at that time, because of their animal-like depiction, which enhanced a negative interpretation of their religious ‘otherness’. The chapter explores how the process of stigmatization involves effects of surprise and wonder, as well as contempt and discredit, dwelling on how the artistic invention of non-human and post-human figures has been charged with solving political and social problems and disorders, providing support not only for religious propaganda, but also for attempts at moral normalization. This publication has been peer reviewed (double blind).
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- 2020
16. Profiles of youth citizenship orientations: the role of the school, neighbourhood, family and peers contexts
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Elvira Cicognani, Iana Tzankova, Gabriele Prati, Peter Noack, Katharina Eckstein, Branje S. (Utrecht University, The Netherlands), Mena-Matos, P. (University of Porto, Portugal), and Elvira Cicognani, Iana Tzankova, Gabriele, Prati, Peter Noack, Katharina Eckstein
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citizenship, participation, adolescents, distrust towards politics, political interest, longitudinal research - Abstract
Studies on youth participation tend to characterize youth as either active “good citizens” or as passive and alienated. It has been argued, however, that low levels of youth political activity are not necessarily indicative of complete disengagement from societal affairs but could be accompanied by interest and latent involvement stemming from a standby/monitorial attitude or from an attitude of distrust and need of critical supervising. A series of research, using a person-centered approach, will be presented with the aim to examine patterns of citizenship orientations among youth identified by manifest participation (civic and political activity), latent engagement (political interest) and one’s position toward institutional politics (institutional trust and external political efficacy). All analyzed data was collected through a two-wave questionnaire within the European-funded H2020 research project CATCH-EyoU. The proposed classification was analyzed in a sample of 1732 late adolescents and young adults (15–30 years old) from Italy, as well as in a cross-national longitudinal sample of 1943 upper secondary school students (15–19 years old) from Italy, Germany, Sweden, Greece and the Czech Republic. The results identify profiles of different levels of engagement, each characterized by either satisfied or dissatisfied attitude towards political institutions. The findings highlight the prevalence of latent engagement and the different faces political distrust may assume, including in different forms of participation (political, civic, online and activist). Moreover, the results explore how membership in the groups can be longitudinally influenced by socio-demographic characteristics and perceived contextual features related to school, neighbourhood, family and peers. Family background, democratic school climate, school participation and critical reflection at school were found to determine differences in the likelihood of adopting specific citizenship orientations among youth.
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- 2020
17. Music Technology with Swing
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ARAMAKI, Mitsuko, Davies, Matthew, Kronland Martinet, Richard, Ystad, Sølvi, Perception, Représentations, Image, Son, Musique (PRISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Ecole supérieure d'Art d'Aix en Provence (ESA AIX), Institute for Systems and Computer Engineering, Technology and Science [Porto] (INESC TEC), Sound and Music Computing Group at INESC TEC, Faculty of Engineering, University of Porto, Portugal, PRISM (AMU-CNRS), Marseille, Aramaki, M., Davies, M.E.P., Kronland-Martinet, R., Ystad, S., Hofmann, A., and Aix Marseille Université (AMU)-Ecole supérieure d'Art d'Aix en Provence (ESA AIX)-Centre National de la Recherche Scientifique (CNRS)
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[SHS.MUSIQ]Humanities and Social Sciences/Musicology and performing arts ,Auditory guidance ,Musicology ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Musical HCIs ,Classification ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,Music Information Retrieval ,Virtual and Augmented Reality ,[INFO.INFO-SD]Computer Science [cs]/Sound [cs.SD] ,Moltimodal perception ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2018
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18. 'Holding the Dream': Women’s Favorite Reading Matter in a Portuguese Prison
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Paula Sequeiros and University of Coimbra, Portugal University of Porto, Portugal
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media_common.quotation_subject ,lcsh:HM401-1281 ,Prison ,050905 science studies ,Romance Novel ,Entertainment ,Social group ,Reflexivity ,Reading (process) ,Ethnography ,Women ,Sociology ,Popular Romance ,Imprisonment ,Prison Libraries ,media_common ,Cultural Tastes ,4. Education ,Light Literature ,05 social sciences ,General Social Sciences ,Gender studies ,language.human_language ,Female Prisons ,lcsh:Sociology (General) ,Reading ,language ,0509 other social sciences ,Portuguese ,050904 information & library sciences - Abstract
The reading practices of women, mediated by a prison library in Portugal, constituted an interesting case study. In Santa Cruz do Bispo prison, female prisoners were increasingly aged and excluded from social groups, less literate, and educated. Many were first-time library users and some were beginning readers. This research aimed to understand their reading practices and preferences, their self-assigned meanings, and the roles of reading in prison. Having become aware that industrial literature romance novels were the most requested items, a critical comparative analysis of the three most requested titles was contrasted with readers’ favorite passages to foster a deeper understanding of their preferences and sustain an integrated analysis. Furthermore, a consensualized definition of a “good read” is presented. The results from ethnography and interviews to readers and staff are analyzed taking into account class, gender, ethnicity, age, occupation, and education of the detainees. Conclusions address the fact that although the prison’s educational service and imprisonment conditions propitiated an increase in reading generally, the library was oriented by educational targets and irresponsive to certain demands expressed by readers. Secondly, women readers were using the available top-selling romance novels to sustain their introspective and prospective work, while reckoning with their past and planning for their future. In addition to this reflexive stance, escapist entertainment and knowledge building were important reading purposes.
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- 2018
19. Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants
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Ezzati, M. and Zhou, B. and Bentham, J. and Di Cesare, M. and Bixby, H. and Danaei, G. and Hajifathalian, K. and Taddei, C. and Carrillo-Larco, R.M. and Djalalinia, S. and Khatibzadeh, S. and Lugero, C. and Peykari, N. and Zhang, W.Z. and Bennett, J. and Bilano, V. and Stevens, G.A. and Cowan, M.J. and Riley, L.M. and Chen, Z. and Hambleton, I.R. and Jackson, R.T. and Kengne, A.P. and Khang, Y.-H. and Laxmaiah, A. and Liu, J. and Malekzadeh, R. and Neuhauser, H.K. and Sorić, M. and Starc, G. and Sundström, J. and Woodward, M. and Abarca-Gómez, L. and Abdeen, Z.A. and Abu-Rmeileh, N.M. and Acosta-Cazares, B. and Adams, R.J. and Aekplakorn, W. and Afsana, K. and Aguilar-Salinas, C.A. and Agyemang, C. and Ahmad, N.A. and Ahmadvand, A. and Ahrens, W. and Ajlouni, K. and Akhtaeva, N. and Al-Raddadi, R. and Ali, M.M. and Ali, O. and Alkerwi, A. and Aly, E. and Amarapurkar, D.N. and Amouyel, P. and Amuzu, A. and Andersen, L.B. and Anderssen, S.A. and Ängquist, L.H. and Anjana, R.M. and Ansong, D. and Aounallah-Skhiri, H. and Araújo, J. and Ariansen, I. and Aris, T. and Arlappa, N. and Arveiler, D. and Aryal, K.K. and Aspelund, T. and Assah, F.K. and Assunção, M.C.F. and Avdicová, M. and Azevedo, A. and Azizi, F. and Babu, B.V. and Bahijri, S. and Balakrishna, N. and Bamoshmoosh, M. and Banach, M. and Bandosz, P. and Banegas, J.R. and Barbagallo, C.M. and Barceló, A. and Barkat, A. and Barros, A.J.D. and Barros, M.V. and Bata, I. and Batieha, A.M. and Batyrbek, A. and Baur, L.A. and Beaglehole, R. and Romdhane, H.B. and Benet, M. and Benson, L.S. and Bernabe-Ortiz, A. and Bernotiene, G. and Bettiol, H. and Bhagyalaxmi, A. and Bharadwaj, S. and Bhargava, S.K. and Bi, Y. and Bikbov, M. and Bista, B. and Bjerregaard, P. and Bjertness, E. and Bjertness, M.B. and Björkelund, C. and Blokstra, A. and Bo, S. and Bobak, M. and Boeing, H. and Boggia, J.G. and Boissonnet, C.P. and Bongard, V. and Borchini, R. and Bovet, P. and Braeckman, L. and Brajkovich, I. and Branca, F. and Breckenkamp, J. and Brenner, H. and Brewster, L.M. and Bruno, G. and Bueno-de-Mesquita, H.B. and Bugge, A. and Burns, C. and Bursztyn, M. and de León, A.C. and Cacciottolo, J. and Cai, H. and Cameron, C. and Can, G. and Cândido, A.P.C. and Capuano, V. and Cardoso, V.C. and Carlsson, A.C. and Carvalho, M.J. and Casanueva, F.F. and Casas, J.-P. and Caserta, C.A. and Chamukuttan, S. and Chan, A.W. and Chan, Q. and Chaturvedi, H.K. and Chaturvedi, N. and Chen, C.-J. and Chen, F. and Chen, H. and Chen, S. and Cheng, C.-Y. and Dekkaki, I.C. and Chetrit, A. and Chiolero, A. and Chiou, S.-T. and Chirita-Emandi, A. and Chirlaque, M.-D. and Cho, B. and Cho, Y. and Christofaro, D.G. and Chudek, J. and Cifkova, R. and Cinteza, E. and Claessens, F. and Clays, E. and Concin, H. and Cooper, C. and Cooper, R. and Coppinger, T.C. and Costanzo, S. and Cottel, D. and Cowell, C. and Craig, C.L. and Crujeiras, A.B. and Cruz, J.J. and D'Arrigo, G. and d'Orsi, E. and Dallongeville, J. and Damasceno, A. and Dankner, R. and Dantoft, T.M. and Dauchet, L. and Davletov, K. and De Backer, G. and De Bacquer, D. and de Gaetano, G. and De Henauw, S. and de Oliveira, P.D. and De Smedt, D. and Deepa, M. and Dehghan, A. and Delisle, H. and Deschamps, V. and Dhana, K. and Di Castelnuovo, A.F. and Dias-da-Costa, J.S. and Diaz, A. and Dickerson, T.T. and Do, H.T.P. and Dobson, A.J. and Donfrancesco, C. and Donoso, S.P. and Döring, A. and Dorobantu, M. and Doua, K. and Drygas, W. and Dulskiene, V. and Džakula, A. and Dzerve, V. and Dziankowska-Zaborszczyk, E. and Eggertsen, R. and Ekelund, U. and El Ati, J. and Elliott, P. and Elosua, R. and Erasmus, R.T. and Erem, C. and Eriksen, L. and Eriksson, J.G. and Escobedo-de la Peña, J. and Evans, A. and Faeh, D. and Fall, C.H. and Farzadfar, F. and Felix-Redondo, F.J. and Ferguson, T.S. and Fernandes, R.A. and Fernández-Bergés, D. and Ferrante, D. and Ferrari, M. and Ferreccio, C. and Ferrieres, J. and Finn, J.D. and Fischer, K. and Föger, B. and Foo, L.H. and Forslund, A.-S. and Forsner, M. and Fouad, H.M. and Francis, D.K. and Franco, M.C. and Franco, O.H. and Frontera, G. and Fuchs, F.D. and Fuchs, S.C. and Fujita, Y. and Furusawa, T. and Gaciong, Z. and Galvano, F. and Garcia-de-la-Hera, M. and Gareta, D. and Garnett, S.P. and Gaspoz, J.-M. and Gasull, M. and Gates, L. and Geleijnse, J.M. and Ghasemian, A. and Ghimire, A. and Giampaoli, S. and Gianfagna, F. and Gill, T.K. and Giovannelli, J. and Goldsmith, R.A. and Gonçalves, H. and Gonzalez-Gross, M. and González-Rivas, J.P. and Gorbea, M.B. and Gottrand, F. and Graff-Iversen, S. and Grafnetter, D. and Grajda, A. and Grammatikopoulou, M.G. and Gregor, R.D. and Grodzicki, T. and Grøntved, A. and Grosso, G. and Gruden, G. and Grujic, V. and Gu, D. and Guan, O.P. and Gudmundsson, E.F. and Gudnason, V. and Guerrero, R. and Guessous, I. and Guimaraes, A.L. and Gulliford, M.C. and Gunnlaugsdottir, J. and Gunter, M. and Gupta, P.C. and Gupta, R. and Gureje, O. and Gurzkowska, B. and Gutierrez, L. and Gutzwiller, F. and Hadaegh, F. and Halkjær, J. and Hardy, R. and Kumar, R.H. and Hata, J. and Hayes, A.J. and He, J. and He, Y. and Hendriks, M.E. and Henriques, A. and Cadena, L.H. and Herrala, S. and Heshmat, R. and Hihtaniemi, I.T. and Ho, S.Y. and Ho, S.C. and Hobbs, M. and Hofman, A. and Dinc, G.H. and Horimoto, A.R. and Hormiga, C.M. and Horta, B.L. and Houti, L. and Howitt, C. and Htay, T.T. and Htet, A.S. and Htike, M.M.T. and Hu, Y. and Huerta, J.M. and Huisman, M. and Husseini, A.S. and Huybrechts, I. and Hwalla, N. and Iacoviello, L. and Iannone, A.G. and Ibrahim, M.M. and Wong, N.I. and Ikeda, N. and Ikram, M.A. and Irazola, V.E. and Islam, M. and al-Safi Ismail, A. and Ivkovic, V. and Iwasaki, M. and Jacobs, J.M. and Jaddou, H. and Jafar, T. and Jamrozik, K. and Janszky, I. and Jasienska, G. and Jelaković, A. and Jelaković, B. and Jennings, G. and Jeong, S.-L. and Jiang, C.Q. and Joffres, M. and Johansson, M. and Jokelainen, J.J. and Jonas, J.B. and Jørgensen, T. and Joshi, P. and Jóźwiak, J. and Juolevi, A. and Jurak, G. and Jureša, V. and Kaaks, R. and Kafatos, A. and Kajantie, E.O. and Kalter-Leibovici, O. and Kamaruddin, N.A. and Karki, K.B. and Kasaeian, A. and Katz, J. and Kauhanen, J. and Kaur, P. and Kavousi, M. and Kazakbaeva, G. and Keil, U. and Boker, L.K. and Keinänen-Kiukaanniemi, S. and Kelishadi, R. and Kemper, H.C.G. and Kengne, A.P. and Kerimkulova, A. and Kersting, M. and Key, T. and Khader, Y.S. and Khalili, D. and Khateeb, M. and Khaw, K.-T. and Kiechl-Kohlendorfer, U. and Kiechl, S. and Killewo, J. and Kim, J. and Kim, Y.-Y. and Klumbiene, J. and Knoflach, M. and Kolle, E. and Kolsteren, P. and Korrovits, P. and Koskinen, S. and Kouda, K. and Kowlessur, S. and Koziel, S. and Kriemler, S. and Kristensen, P.L. and Krokstad, S. and Kromhout, D. and Kruger, H.S. and Kubinova, R. and Kuciene, R. and Kuh, D. and Kujala, U.M. and Kulaga, Z. and Kumar, R.K. and Kurjata, P. and Kusuma, Y.S. and Kuulasmaa, K. and Kyobutungi, C. and Laatikainen, T. and Lachat, C. and Lam, T.H. and Landrove, O. and Lanska, V. and Lappas, G. and Larijani, B. and Laugsand, L.E. and Bao, K.L.N. and Le, T.D. and Leclercq, C. and Lee, J. and Lee, J. and Lehtimäki, T. and León-Muñoz, L.M. and Levitt, N.S. and Li, Y. and Lilly, C.L. and Lim, W.-Y. and Lima-Costa, M.F. and Lin, H.-H. and Lin, X. and Lind, L. and Linneberg, A. and Lissner, L. and Litwin, M. and Lorbeer, R. and Lotufo, P.A. and Lozano, J.E. and Luksiene, D. and Lundqvist, A. and Lunet, N. and Lytsy, P. and Ma, G. and Ma, J. and Machado-Coelho, G.L.L. and Machi, S. and Maggi, S. and Magliano, D.J. and Magriplis, E. and Majer, M. and Makdisse, M. and Malhotra, R. and Rao, K.M. and Malyutina, S. and Manios, Y. and Mann, J.I. and Manzato, E. and Margozzini, P. and Marques-Vidal, P. and Marques, L.P. and Marrugat, J. and Martorell, R. and Mathiesen, E.B. and Matijasevich, A. and Matsha, T.E. and Mbanya, J.N. and Posso, A.J.M.D. and McFarlane, S.R. and McGarvey, S.T. and McLachlan, S. and McLean, R.M. and McLean, S.B. and McNulty, B.A. and Mediene-Benchekor, S. and Medzioniene, J. and Meirhaeghe, A. and Meisinger, C. and Menezes, A.B. and Menon, G.R. and Meshram, I.I. and Metspalu, A. and Meyer, H.E. and Mi, J. and Mikkel, K. and Miller, J.C. and Minderico, C.S. and Miquel, J.F. and Miranda, J.J. and Mirrakhimov, E. and Mišigoj-Durakovic, M. and Modesti, P.A. and Mohamed, M.K. and Mohammad, K. and Mohammadifard, N. and Mohan, V. and Mohanna, S. and Yusoff, M.F.M.D. and Møllehave, L.T. and Møller, N.C. and Molnár, D. and Momenan, A. and Mondo, C.K. and Monyeki, K.D.K. and Moon, J.S. and Moreira, L.B. and Morejon, A. and Moreno, L.A. and Morgan, K. and Moschonis, G. and Mossakowska, M. and Mostafa, A. and Mota, J. and Motlagh, M.E. and Motta, J. and Msyamboza, K.P. and ThetMu, T. and Muiesan, M.L. and Müller-Nurasyid, M. and Murphy, N. and Mursu, J. and Musil, V. and Nabipour, I. and Nagel, G. and Naidu, B.M. and Nakamura, H. and Námešná, J. and Nang, E.K. and Nangia, V.B. and Narake, S. and Nauck, M. and Navarrete-Muñoz, E.M. and Ndiaye, N.C. and Neal, W.A. and Nenko, I. and Neovius, M. and Nervi, F. and Nguyen, C.T. and Nguyen, N.D. and Nguyen, Q.N. and Nguyen, Q.V. and Nieto-Martínez, R.E. and Niiranen, T.J. and Ning, G. and Ninomiya, T. and Nishtar, S. and Noale, M. and Noboa, O.A. and Noorbala, A.A. and Norat, T. and Noto, D. and Al Nsour, M. and O'Reilly, D. and Oda, E. and Oehlers, G. and Oh, K. and Ohara, K. and Olinto, M.T.A. and Oliveira, I.O. and Omar, M.A. and Onat, A. and Ong, S.K. and Ono, L.M. and Ordunez, P. and Ornelas, R. and Osmond, C. and Ostojic, S.M. and Ostovar, A. and Otero, J.A. and Overvad, K. and Owusu-Dabo, E. and Paccaud, F.M. and Padez, C. and Pahomova, E. and Pajak, A. and Palli, D. and Palmieri, L. and Pan, W.-H. and Panda-Jonas, S. and Panza, F. and Papandreou, D. and Park, S.-W. and Parnell, W.R. and Parsaeian, M. and Patel, N.D. and Pecin, I. and Pednekar, M.S. and Peer, N. and Peeters, P.H. and Peixoto, S.V. and Peltonen, M. and Pereira, A.C. and Peters, A. and Petersmann, A. and Petkeviciene, J. and Pham, S.T. and Pigeot, I. and Pikhart, H. and Pilav, A. and Pilotto, L. and Pitakaka, F. and Piwonska, A. and Plans-Rubió, P. and Polašek, O. and Porta, M. and Portegies, M.L.P. and Pourshams, A. and Poustchi, H. and Pradeepa, R. and Prashant, M. and Price, J.F. and Puder, J.J. and Puiu, M. and Punab, M. and Qasrawi, R.F. and Qorbani, M. and Bao, T.Q. and Radic, I. and Radisauskas, R. and Rahman, M. and Raitakari, O. and Raj, M. and Rao, S.R. and Ramachandran, A. and Ramos, E. and Rampal, L. and Rampal, S. and Rangel Reina, D.A. and Redon, J. and Reganit, P.M. and Ribeiro, R. and Riboli, E. and Rigo, F. and Rinke de Wit, T.F. and Ritti-Dias, R.M. and Robinson, S.M. and Robitaille, C. and Rodríguez-Artalejo, F. and Rodriguez-Perez, M.C. and Rodríguez-Villamizar, L.A. and Rojas-Martinez, R. and Romaguera, D. and Ronkainen, K. and Rosengren, A. and Roy, J.G.R. and Rubinstein, A. and Ruiz-Betancourt, B.S. and Rutkowski, M. and Sabanayagam, C. and Sachdev, H.S. and Saidi, O. and Sakarya, S. and Salanave, B. and Martinez, E.S. and Salmerón, D. and Salomaa, V. and Salonen, J.T. and Salvetti, M. and Sánchez-Abanto, J. and Sans, S. and Santos, D.A. and Santos, I.S. and Santos, R.N. and Santos, R. and Saramies, J.L. and Sardinha, L.B. and Sarganas, G. and Sarrafzadegan, N. and Saum, K.-U. and Savva, S. and Scazufca, M. and Schargrodsky, H. and Schipf, S. and Schmidt, C.O. and Schöttker, B. and Schultsz, C. and Schutte, A.E. and Sein, A.A. and Sen, A. and Senbanjo, I.O. and Sepanlou, S.G. and Sharma, S.K. and Shaw, J.E. and Shibuya, K. and Shin, D.W. and Shin, Y. and Si-Ramlee, K. and Siantar, R. and Sibai, A.M. and Silva, D.A.S. and Simon, M. and Simons, J. and Simons, L.A. and Sjöström, M. and Skovbjerg, S. and Slowikowska-Hilczer, J. and Slusarczyk, P. and Smeeth, L. and Smith, M.C. and Snijder, M.B. and So, H.-K. and Sobngwi, E. and Söderberg, S. and Solfrizzi, V. and Sonestedt, E. and Song, Y. and Sørensen, T.I.A. and Soric, M. and Jérome, C.S. and Soumare, A. and Staessen, J.A. and Stathopoulou, M.G. and Stavreski, B. and Steene-Johannessen, J. and Stehle, P. and Stein, A.D. and Stergiou, G.S. and Stessman, J. and Stieber, J. and Stöckl, D. and Stocks, T. and Stokwiszewski, J. and Stronks, K. and Strufaldi, M.W. and Sun, C.-A. and Sung, Y.-T. and Suriyawongpaisal, P. and Sy, R.G. and Tai, E.S. and Tammesoo, M.-L. and Tamosiunas, A. and Tan, E.J. and Tang, X. and Tanser, F. and Tao, Y. and Tarawneh, M.R. and Tarqui-Mamani, C.B. and Tautu, O.-F. and Taylor, A. and Theobald, H. and Theodoridis, X. and Thijs, L. and Thuesen, B.H. and Tjonneland, A. and Tolonen, H.K. and Tolstrup, J.S. and Topbas, M. and Topór-Madry, R. and Tormo, M.J. and Torrent, M. and Traissac, P. and Trichopoulos, D. and Trichopoulou, A. and Trinh, O.T.H. and Trivedi, A. and Tshepo, L. and Tulloch-Reid, M.K. and Tullu, F. and Tuomainen, T.-P. and Tuomilehto, J. and Turley, M.L. and Tynelius, P. and Tzourio, C. and Ueda, P. and Ugel, E.E. and Ulmer, H. and Uusitalo, H.M.T. and Valdivia, G. and Valvi, D. and van der Schouw, Y.T. and Van Herck, K. and Van Minh, H. and van Rossem, L. and Van Schoor, N.M. and van Valkengoed, I.G.M. and Vanderschueren, D. and Vanuzzo, D. and Vatten, L. and Vega, T. and Velasquez-Melendez, G. and Veronesi, G. and Verschuren, W.M.M. and Verstraeten, R. and Victora, C.G. and Viet, L. and Viikari-Juntura, E. and Vineis, P. and Vioque, J. and Virtanen, J.K. and Visvikis-Siest, S. and Viswanathan, B. and Vlasoff, T. and Vollenweider, P. and Voutilainen, S. and Wade, A.N. and Wagner, A. and Walton, J. and Wan Bebakar, W.M. and Wan Mohamud, W.N. and Wanderley, R.S., Jr. and Wang, M.-D. and Wang, Q. and Wang, Y.X. and Wang, Y.-W. and Wannamethee, S.G. and Wareham, N. and Wedderkopp, N. and Weerasekera, D. and Whincup, P.H. and Widhalm, K. and Widyahening, I.S. and Wiecek, A. and Wijga, A.H. and Wilks, R.J. and Willeit, J. and Willeit, P. and Williams, E.A. and Wilsgaard, T. and Wojtyniak, B. and Wong-McClure, R.A. and Wong, J.Y.Y. and Wong, T.Y. and Woo, J. and Wu, A.G. and Wu, F.C. and Wu, S. and Xu, H. and Yan, W. and Yang, X. and Ye, X. and Yiallouros, P.K. and Yoshihara, A. and Younger-Coleman, N.O. and Yusoff, A.F. and Zainuddin, A.A. and Zambon, S. and Zampelas, A. and Zdrojewski, T. and Zeng, Y. and Zhao, D. and Zhao, W. and Zheng, W. and Zheng, Y. and Zhu, D. and Zhussupov, B. and Zimmermann, E. and Cisneros, J.Z. and NCD Risk Factor Collaboration (NCD-RisC), Imperial College London, London, W2 1PG, United Kingdom, Imperial College London, United Kingdom, University of Kent, United Kingdom, Middlesex University, United Kingdom, Harvard TH Chan School of Public Health, United States, Cleveland Clinic, United States, Universidad Peruana Cayetano Heredia, Peru, Tehran University of Medical Sciences, Iran, Ministry of Health and Medical Education, Iran, Brandeis University, United States, Mulago Hospital, Uganda, Uganda Heart Institute, Uganda, World Health Organization, Switzerland, University of Oxford, United Kingdom, The University of the West Indies, Barbados, University of Auckland, New Zealand, South African Medical Research Council, South Africa, Seoul National University, South Korea, National Institute of Nutrition, India, Capital Medical University Beijing An Zhen Hospital, China, Robert Koch Institute, Germany, German Center for Cardiovascular Research, Germany, University of Zagreb, Croatia, University of Ljubljana, Slovenia, Uppsala University, Sweden, University of New South Wales, Australia, Caja Costarricense de Seguro Social, Costa Rica, Al-Quds University, Palestine, Birzeit University, Palestine, Instituto Mexicano del Seguro Social, Mexico, The University of Adelaide, Australia, Mahidol University, Thailand, BRAC, Bangladesh, Instituto Nacional de Ciencias Médicas y Nutricion, Mexico, University of Amsterdam, Netherlands, Ministry of Health Malaysia, Malaysia, Non- Communicable Diseases Research Center, Iran, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Germany, National Center for Diabetes and Endocrinology, Jordan, Kazakh National Medical University, Kazakhstan, King Abdulaziz University, Saudi Arabia, Universiti Malaysia Sabah, Malaysia, Luxembourg Institute of Health, Luxembourg, World Health Organization Regional Office for the Eastern Mediterranean, Egypt, Bombay Hospital and Medical Research Centre, India, Lille University and Hospital, France, London School of Hygiene and Tropical Medicine, United Kingdom, Western Norway University of Applied Sciences, Norway, Norwegian School of Sport Sciences, Norway, Bispebjerg and Frederiksberg Hospitals, Denmark, Madras Diabetes Research Foundation, India, Komfo Anokye Teaching Hospital, Ghana, National Institute of Public Health, Tunisia, Universidade do Porto, Portugal, Norwegian Institute of Public Health, Norway, Strasbourg University and Hospital, France, Nepal Health Research Council, Nepal, University of Iceland, Iceland, University of Yaoundé 1, Cameroon, Federal University of Pelotas, Brazil, Regional Authority of Public Health, Banska Bystrica, Slovakia, University of Porto Medical School, Portugal, Shahid Beheshti University of Medical Sciences, Iran, Indian Council of Medical Research, India, University of Science and Technology, Yemen, Medical University of Lodz, Poland, Medical University of Gdansk, Poland, Universidad Autónoma de Madrid, Spain, University of Palermo, Italy, Pan American Health Organization, United States, Université Mohammed V de Rabat, Morocco, University of Pernambuco, Brazil, Dalhousie University, Canada, Jordan University of Science and Technology, Jordan, University of Sydney, Australia, University Tunis El Manar, Tunisia, CAFAM University Foundation, Colombia, University of Utah School of Medicine, United States, Lithuanian University of Health Sciences, Lithuania, University of São Paulo, Brazil, BJ Medical College, India, Chirayu Medical College, India, SL Jain Hospital, India, Shanghai Jiao-Tong University School of Medicine, China, Ufa Eye Research Institute, Russian Federation, University of Southern Denmark, Denmark, University of Greenland, Greenland, University of Oslo, Norway, University of Gothenburg, Sweden, National Institute for Public Health and the Environment, Netherlands, University of Turin, Italy, University College London, United Kingdom, German Institute of Human Nutrition, Germany, Universidad de la República, Uruguay, CEMIC, Argentina, Toulouse University School of Medicine, France, University Hospital of Varese, Italy, Ministry of Health, Seychelles, University of Lausanne, Switzerland, Ghent University, Belgium, Universidad Central de Venezuela, Venezuela, Bielefeld University, Germany, German Cancer Research Center, Germany, Cork Institute of Technology, Ireland, Hadassah-Hebrew University Medical Center, Israel, Universidad de La Laguna, Spain, University of Malta, Malta, Vanderbilt University, United States, Canadian Fitness and Lifestyle Research Institute, Canada, Istanbul University, Turkey, Universidade Federal de Juiz de Fora, Brazil, Cardiologia di Mercato S. Severino, Italy, Karolinska Institutet, Sweden, University of Porto, Portugal, Santiago de Compostela University, Spain, Associazione Calabrese di Epatologia, Italy, India Diabetes Research Foundation, India, Duke-NUS Medical School, Singapore, National Institute of Medical Statistics, India, Academia Sinica, Taiwan, Capital Institute of Pediatrics, China, Duke University, United States, Kailuan General Hospital, China, The Gertner Institute for Epidemiology and Health Policy Research, Israel, University of Bern, Switzerland, Ministry of Health and Welfare, Taiwan, Victor Babes University of Medicine and Pharmacy Timisoara, Romania, Murcia Regional Health Council, Spain, Seoul National University College of Medicine, South Korea, Korea Centers for Disease Control and Prevention, South Korea, Universidade Estadual Paulista, Brazil, Medical University of Silesia, Poland, Charles University in Prague, Czech Republic, Carol Davila University of Medicine and Pharmacy, Romania, Katholieke Universiteit Leuven, Belgium, Agency for Preventive and Social Medicine, Austria, University of Southampton, United Kingdom, IRCCS Istituto Neurologico Mediterraneo Neuromed, Italy, Institut Pasteur de Lille, France, CIBEROBN, Spain, National Council of Research, Italy, Universidade Federal de Santa Catarina, Brazil, Eduardo Mondlane University, Mozambique, Bispebjerg and Frederiksberg Hospital, Denmark, Lille University Hospital, France, Erasmus Medical Center Rotterdam, Netherlands, University of Montreal, Canada, French Public Health Agency, France, Universidade do Vale do Rio dos Sinos, Brazil, National Council of Scientific and Technical Research, Argentina, National Institute of Nutrition, Viet Nam, University of Queensland, Australia, Istituto Superiore di Sanità, Italy, Universidad de Cuenca, Ecuador, Helmholtz Zentrum München, Germany, Ministère de la Santé et de la Lutte Contre le Sida, Cote d'Ivoire, The Cardinal Wyszynski Institute of Cardiology, Poland, University of Latvia, Latvia, National Institute of Nutrition and Food Technology, Tunisia, Institut Hospital del Mar d'Investigacions Mèdiques, Spain, University of Stellenbosch, South Africa, Karadeniz Technical University, Turkey, National Institute for Health and Welfare, Finland, Queen's University of Belfast, United Kingdom, University of Zurich, Switzerland, Centro de Salud Villanueva Norte, Spain, The University of the West Indies, Jamaica, Hospital Don Benito-Villanueva de la Serena, Spain, Ministry of Health, Argentina, Council for Agricultural Research and Economics, Italy, Pontificia Universidad Católica de Chile, Chile, University of Manchester, United Kingdom, University of Tartu, Estonia, Universiti Sains Malaysia, Malaysia, Umeå University, Sweden, Dalarna University, Sweden, Federal University of São Paulo, Brazil, Hospital Universitario Son Espases, Spain, Hospital de Clinicas de Porto Alegre, Brazil, Universidade Federal do Rio Grande do Sul, Brazil, Kindai University, Japan, Kyoto University, Japan, Medical University of Warsaw, Poland, University of Catania, Italy, CIBER en Epidemiología y Salud Pública, Spain, University of KwaZulu-Natal, South Africa, Geneva University Hospitals, Switzerland, Australian Bureau of Statistics, Australia, Wageningen University, Netherlands, B P Koirala Institute of Health Sciences, Nepal, University of Insubria, Italy, Ministry of Health, Israel, The Andes Clinic of Cardio-Metabolic Studies, Venezuela, National Institute of Hygiene, Epidemiology and Microbiology, Cuba, Université de Lille 2, France, Institute for Clinical and Experimental Medicine, Czech Republic, Children'sMemorial Health Institute, Poland, Alexander Technological Educational Institute, Greece, Jagiellonian University Medical College, Poland, Azienda Ospedaliera Universitaria Policlinico Vittorio Emanuele, Italy, University of Novi Sad, Serbia, National Center of Cardiovascular Diseases, China, Singapore Eye Research Institute, Singapore, Icelandic Heart Association, Iceland, Universidad Icesi, Colombia, King's College London, United Kingdom, International Agency for Research on Cancer, France, Healis-Sekhsaria Institute for Public Health, India, Eternal Heart Care Centre and Research Institute, India, University of Ibadan, Nigeria, Children's Memorial Health Institute, Poland, Institute for Clinical Effectiveness and Health Policy, Argentina, Danish Cancer Society Research Centre, Denmark, Kyushu University, Japan, Tulane University, United States, Chinese Center for Disease Control and Prevention, China, Academic Medical Center of University of Amsterdam, Netherlands, National Institute of Public Health, Mexico, Oulu University Hospital, Finland, Chronic Diseases Research Center, Iran, University of Hong Kong, Hong Kong, The Chinese University of Hong Kong, Hong Kong, University of Western Australia, Australia, Celal Bayar University, Turkey, Heart Institute, Brazil, Fundación Oftalmológica de Santander, Colombia, University of Oran 1, Algeria, Independent Public Health Specialist, Myanmar, Ministry of Health, Myanmar, Peking University, China, VU University Medical Center and VU University, Netherlands, American University of Beirut, Lebanon, Cairo University, Egypt, National Institute of Health and Nutrition, Japan, Aga Khan University, Pakistan, UHC Zagreb, Croatia, Niigata University, Japan, Hadassah University Medical Center, Israel, Duke- NUS Medical School, Singapore, Norwegian University of Science and Technology, Norway, University of Zagreb School of Medicine, Croatia, Heart Foundation, Australia, National Health Insurance Service, South Korea, Guangzhou 12th Hospital, China, Simon Fraser University, Canada, Ruprecht-Karls- University of Heidelberg, Germany, Research Centre for Prevention and Health, Denmark, World Health Organization Country Office, India, Czestochowa University of Technology, Poland, University of Crete, Greece, Universiti Kebangsaan Malaysia, Malaysia, Johns Hopkins Bloomberg School of Public Health, United States, University of Eastern Finland, Finland, National Institute of Epidemiology, India, University of Münster, Germany, Israel Center for Disease Control, Israel, Research Institute for Primordial Prevention of Noncommunicable Disease, Iran, VU University Medical Center, Netherlands, Kyrgyz State Medical Academy, Kyrgyzstan, Research Institute of Child Nutrition, Germany, University of Cambridge, United Kingdom, Medical University of Innsbruck, Austria, Muhimbili University of Health and Allied Sciences, Tanzania, National Cancer Center, South Korea, Institute of Tropical Medicine, Belgium, Tartu University Clinics, Estonia, Ministry of Health and Quality of Life, Mauritius, Polish Academy of Sciences Anthropology Unit in Wroclaw, Poland, University of Zürich, Switzerland, University of Groningen, Netherlands, North-West University, South Africa, National Institute of Public Health, Czech Republic, University of Jyväskylä, Finland, Amrita Institute of Medical Sciences, India, All India Institute of Medical Sciences, India, African Population and Health Research Center, Kenya, Ministerio de Salud Pública, Cuba, Sahlgrenska Academy, Sweden, Endocrinology and Metabolism Research Center, Iran, Food and Agriculture Organization of the United Nations, Italy, National University of Singapore, Singapore, Tampere University Hospital, Finland, University of Cape Town, South Africa, West Virginia University, United States, Oswaldo Cruz Foundation Rene Rachou Research Institute, Brazil, National Taiwan University, Taiwan, University of Chinese Academy of Sciences, China, University Medicine Greifswald, Germany, Consejería de Sanidad Junta de Castilla y León, Spain, University of Uppsala, Sweden, Universidade Federal de Ouro Preto, Brazil, The Jikei University School of Medicine, Japan, National Research Council, Italy, Baker Heart and Diabetes Institute, Australia, Agricultural University of Athens, Greece, Hospital Israelita Albert Einstein, Brazil, Shiraz University of Medical Sciences, Iran, Institute of Internal and Preventive Medicine, Russian Federation, Harokopio University, Greece, University of Otago, New Zealand, University of Padova, Italy, Lausanne University Hospital, Switzerland, CIBERCV, Spain, Emory University, United States, UiT The Arctic University of Norway, Norway, Cape Peninsula University of Technology, South Africa, Gorgas Memorial Institute of Health Studies, Panama, Brown University, United States, University of Edinburgh, United Kingdom, Statistics Canada, Canada, University College Dublin, Ireland, Institut National de la Santé et de la Recherche Médicale, France, Lusófona University, Portugal, Universita' degli Studi di Firenze, Italy, Ain Shams University, Egypt, Hypertension Research Center, Iran, University of Pécs, Hungary, Seoul National University Children's Hospital, South Korea, University Medical Science, Cuba, Universidad de Zaragoza, Spain, RCSI Dublin, Ireland, La Trobe University, Australia, International Institute of Molecular and Cell Biology, Poland, Ahvaz Jundishapur University of Medical Sciences, Iran, Gorgas Memorial Institute of Public Health, Panama, World Health Organization Country Office, Malawi, Department of Public Health, Myanmar, University of Brescia, Italy, Bushehr University of Medical Sciences, Iran, Ulm University, Germany, Kobe University, Japan, Suraj Eye Institute, India, University Medicine of Greifswald, Germany, INSERM, France, National Institute of Hygiene and Epidemiology, Viet Nam, The University of Pharmacy and Medicine of Ho Chi Minh City, Viet Nam, Hanoi Medical University, Viet Nam, National Hospital of Endocrinology, Viet Nam, Miami Veterans Affairs Healthcare System, United States, University of Turku Tyks, Finland, Heartfile, Pakistan, Eastern Mediterranean Public Health Network, Jordan, Tachikawa General Hospital, Japan, Academic Hospital of Paramaribo, Suriname, Ministry of Health, Brunei Darussalam, University of Madeira, Portugal, MRC Lifecourse Epidemiology Unit, United Kingdom, Aarhus University, Denmark, Kwame Nkrumah University of Science and Technology, Ghana, Institute for Social and Preventive Medicine, Switzerland, University of Coimbra, Portugal, Cancer Prevention and Research Institute, Italy, Ruprecht-Karls-University of Heidelberg, Germany, IRCCS Casa Sollievo della Sofferenza, Italy, Zayed University, United Arab Emirates, Catholic University of Daegu, South Korea, Jivandeep Hospital, India, University Hospital Centre Zagreb, Croatia, University Medical Center Utrecht, Netherlands, Vietnam National Heart Institute, Viet Nam, University of Sarajevo, Bosnia and Herzegovina, Cardiovascular Prevention Centre Udine, Italy, Ministry of Health and Medical Services, Solomon Islands, Public Health Agency of Catalonia, Spain, University of Split, Croatia, Digestive Oncology Research Center, Iran, Digestive Disease Research Institute, Iran, Alborz University of Medical Sciences, Iran, Ministry of Health, Viet Nam, University of Turku, Finland, Universiti Putra Malaysia, Malaysia, University of Malaya, Malaysia, University of Valencia, Spain, University of the Philippines, Philippines, Minas Gerais State Secretariat for Health, Brazil, Health Center San Agustín, Spain, PharmAccess Foundation, Netherlands, Universidade Nove de Julho, Brazil, Public Health Agency of Canada, Canada, Canarian Health Service, Spain, Universidad Industrial de Santander, Colombia, Instituto Nacional de Salud Pública, Mexico, Sitaram Bhartia Institute of Science and Research, India, Marmara University, Turkey, CIBER de Epidemiología y Salud Pública, Spain, University of Helsinki, Finland, National Institute of Health, Peru, Catalan Department of Health, Spain, Universidade de Lisboa, Portugal, University of Sao Paulo Clinics Hospital, Brazil, South Karelia Social and Health Care District, Finland, Isfahan Cardiovascular Research Center, Iran, Research and Education Institute of Child Health, Cyprus, Hospital Italiano de Buenos Aires, Argentina, Lagos State University College of Medicine, Nigeria, The University of Tokyo, Japan, Samsung Medical Center, South Korea, Federal University of Santa Catarina, Brazil, St Vincent's Hospital, Australia, Academic Medical Center Amsterdam, Netherlands, University of Bari, Italy, Lund University, Sweden, University of Copenhagen, Denmark, Institut Régional de Santé Publique, Benin, University of Bordeaux, France, University of Leuven, Belgium, Bonn University, Germany, Sotiria Hospital, Greece, National Institute of Public Health- National Institute of Hygiene, Poland, Fu Jen Catholic University, Taiwan, Ministry of Health, Jordan, Health Service of Murcia, Spain, IB-SALUT Area de Salut de Menorca, Spain, Institut de Recherche pour le Développement, France, Hellenic Health Foundation, Greece, GovernmentMedical College, India, Sefako Makgatho Health Science University, South Africa, Addis Ababa University, Ethiopia, Dasman Diabetes Institute, Kuwait, Ministry of Health, New Zealand, Universidad Centro-Occidental Lisandro Alvarado, Venezuela, University of Tampere Tays Eye Center, Finland, Utrecht University, Netherlands, Hanoi University of Public Health, Viet Nam, Amsterdam Public Health Research Institute, Netherlands, Universidade Federal de Minas Gerais, Brazil, Finnish Institute of Occupational Health, Finland, Universidad Miguel Hernandez, Spain, North Karelian Center for Public Health, Finland, University of the Witwatersrand, South Africa, University of Strasbourg, France, Institute for Medical Research, Malaysia, Xinjiang Medical University, China, Capital Medical University, China, St George's, University of London, United Kingdom, Medical University of Vienna, Austria, Universitas Indonesia, Indonesia, National Institute of Public Health-National Institute of Hygiene, Poland, Institute of Food and Nutrition Development of Ministry of Agriculture, China, Children's Hospital of Fudan University, China, University of Cyprus, Cyprus, Universiti Teknologi MARA, Malaysia, Inner Mongolia Medical University, China, Universidad Politécnica de Madrid, Spain, State University of Montes Claros, Brazil, and University of Limpopo, South Africa
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sense organs - Abstract
Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probittransformed) prevalence of raised blood pressure and age-group- and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the highincome Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups. © The Author(s) 2018.
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- 2018
20. Proceedings of the 13the symposium on Computer Music Multidisciplinary Research, 'Music Technology with Swing'
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Kronland-Martinet, Richard, Ystad, Sølvi, Aramaki, Mitsuko, Perception, Représentations, Image, Son, Musique (PRISM), Aix Marseille Université (AMU)-Ecole supérieure d'Art d'Aix en Provence (ESA AIX)-Centre National de la Recherche Scientifique (CNRS), INESC TEC , Faculty of Engineering , University of Porto, Portugal et PRISM, AMU-CNRS, France, R. Kronland-Martinet, S. Ystad, and M. Aramaki
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[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph] ,[INFO.INFO-SD]Computer Science [cs]/Sound [cs.SD] ,[INFO.INFO-DS]Computer Science [cs]/Data Structures and Algorithms [cs.DS] ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,[INFO.INFO-HC]Computer Science [cs]/Human-Computer Interaction [cs.HC] ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] - Abstract
International audience; CMMR 2017 represents 13th edition of the symposium series, with the first taking place in Montpellier, France in 2003. 2017 also marks a return back to Europe after the 2016 edition in São Paulo, Brazil, but maintains a strong link with 2016, via the Portuguese language.CMMR 2017 is jointly organised by the Sound and Music Computing Group at INESC TEC together with the Orquestra Jazz de Matosinhos and AMU-CNRS-PRISM.
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- 2017
21. Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting
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C. Marquette, François Lux, Eric Allémann, Éva Tóth, Mireille Dumoulin, Laurence Heinrich-Balard, Olivier Tillement, Pascaline Rivory, Maria João Saraiva, Jean-François Morfin, Jonathan Pansieri, Nathalie Martine Stransky-Heilkron, Marie Plissonneau, Vincent Forge, Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Nano-H S.A.S, Nano-H S.A.S, 38070 Saint Quentin Fallavier, France, Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), School of Pharmaceutical Sciences, Université de Genève = University of Geneva (UNIGE), Laboratoire d'Enzymologie et Repliement des Protéines, Centre d'Ingénierie des Protéines, Université de Liège, Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Centre de biophysique moléculaire (CBM), Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Inovação e Investigação em Saúde (I3S), University of Porto, Portugal, Molecular Neurobiology Group, IBMC - Institute for Molecular & Cell Biology, University of Porto, 4150-180 Porto, Portugal., GON, Nathalie, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University of Geneva [Switzerland], Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA), and Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)
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0301 basic medicine ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Medicine (miscellaneous) ,Nanoparticle ,Amylin ,Peptide ,Gadolinium ,Plaque, Amyloid ,Multimodal Imaging ,chemistry.chemical_compound ,Amyloid disease ,Mice ,General Materials Science ,chemistry.chemical_classification ,ddc:615 ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Aniline Compounds ,biology ,Brain ,Immunohistochemistry ,Islet Amyloid Polypeptide ,[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,amyloid imaging ,Materials science ,Amyloid ,Biomedical Engineering ,[SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics ,Bioengineering ,Development ,03 medical and health sciences ,Alzheimer Disease ,Animals ,Humans ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Amyloid beta-Peptides ,PIB ,amyloidoses ,gadolinium-based nanoparticles ,Single-Domain Antibodies ,Combinatorial chemistry ,In vitro ,nanobody ,Transthyretin ,Thiazoles ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,030104 developmental biology ,chemistry ,Diabetes Mellitus, Type 2 ,biology.protein ,Biophysics ,Nanoparticles ,Pittsburgh compound B ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Aim: Gadolinium-based nanoparticles were functionalized with either the Pittsburgh compound B or a nanobody (B10AP) in order to create multimodal tools for an early diagnosis of amyloidoses. Materials & methods: The ability of the functionalized nanoparticles to target amyloid fibrils made of β-amyloid peptide, amylin or Val30Met-mutated transthyretin formed in vitro or from pathological tissues was investigated by a range of spectroscopic and biophysics techniques including fluorescence microscopy. Results: Nanoparticles functionalized by both probes efficiently interacted with the three types of amyloid fibrils, with KD values in 10 micromolar and 10 nanomolar range for, respectively, Pittsburgh compound B and B10AP nanoparticles. Moreover, they allowed the detection of amyloid deposits on pathological tissues. Conclusion: Such functionalized nanoparticles could represent promising flexible and multimodal imaging tools for the early diagnostic of amyloid diseases, in other words, Alzheimer's disease, Type 2 diabetes mellitus and the familial amyloidotic polyneuropathy.
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- 2017
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22. QualityMatters: How and under what conditions does quality in early education and care matter? A study across four European countries
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Joana Cadima, University of Porto, Portugal, and Faculdade de Psicologia e de Ciências da Educação
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jakość systemu ECEC ,Process (engineering) ,business.industry ,media_common.quotation_subject ,Public relations ,Child development ,lcsh:Education (General) ,Variation (linguistics) ,Political science ,cross-country ,przegląd międzynarodowy ,Quality (business) ,European commission ,interakcje nauczyciel-dziecko ,lcsh:L7-991 ,business ,Function (engineering) ,teacher-child interactions ,ECEC quality ,media_common - Abstract
QualityMatters, an extension of a European Commission funded study, the CARE project, intends to examine whether the quality of teacher-child interactions varies as a function of particular classroom features (e.g., types of activities, content, and grouping), to answer the overarching question: how and under what conditions does quality in early education and care matter? Through a cross-cultural process-oriented approach, the researchers in QualityMatters will capitalize on the variation in the ECEC systems present in 4 European countries (Finland, Netherlands, Poland, Portugal) to examine the complex relations of teachers’ choices regarding the activity and teacher-child interactions. The project will examine the extent to which children’s classroom interactions with teachers vary across activity settings, while taking into consideration country specifications regarding structural regulations. While much of the ECEC research has examined process and structural quality as separated constructs, QualityMatters will look at aspects at the intersection of process and structure, likely to be relevant for child development and learning. QualityMatters to kontynuacja projektu CARE finansowanego przez Komisję Europejską. Celem projektu jest zbadanie, czy jakość interakcji między nauczycielem i dzieckiem jest różna w zależności od poszczególnych cech charakteryzujących klasę (np. rodzaje aktywności, treści i grup), aby znaleźć odpowiedź na nadrzędne pytanie: w jaki sposób i w jakich warunkach jakość w zakresie wczesnej edukacji i opieki ma znaczenie? Dzięki międzykulturowemu podejściu zorientowanemu na proces naukowcy zaangażowani w QualityMatters wykorzystają różnorodność systemów ECEC obecnych w 4 krajach europejskich (Finlandia, Holandia, Polska, Portugalia) w celu zbadania złożonych relacji, związanych z wyborami dokonywanymi przez nauczycieli w zakresie działalności i interakcji między nauczycielem a dzieckiem. W naszym projekcie przeanalizujemy zakres, w jakim interakcje dzieci w klasie z nauczycielami różnią się w zależności od warunków aktywności, biorąc pod uwagę specyfikacje krajowe dotyczące przepisów strukturalnych. Podczas gdy znaczna część badań dotyczących ECEC traktowała jakość strukturalną i procesową jako oddzielne konstrukty, QualityMatters przeanalizuje aspekty w miejscu krzyżowania się procesów i struktur, które prawdopodobnie okażą się istotne dla rozwoju dziecka i uczenia się.
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- 2017
23. Consensus Statement of the European Urology Association and the European Urogynaecological Association on the Use of Implanted Materials for Treating Pelvic Organ Prolapse and Stress Urinary Incontinence
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Frank Van der Aa, Alfredo L. Milani, Jean Nicolas Cornu, Heinz Koelbl, John Heesakkers, Mohamed Abdel-Fattah, Xavier Deffieux, Manfred P. Wirth, Salvador Arlandis, Stefano Salvatore, Ricarda M. Bauer, Christopher R. Chapple, Fiona C. Burkhard, Alfons Gunnemann, Gert Naumann, David Castro-Diaz, Walter Artibani, Sheila MacNeil, Maria Gyhagen, Jan Deprest, Francesco Montorsi, Linda Cardozo, Jan-Paul W. R. Roovers, Tufan Tarcan, Karl-Dietrich Sievert, Francisco Cruz, Sheffield Teaching Hospitals National Health Service Foundation Trust, Instituto de Inovação e Investigação em Saúde (I3S), University of Porto, Portugal, Molecular Neurobiology Group, IBMC - Institute for Molecular & Cell Biology, University of Porto, 4150-180 Porto, Portugal., service de gynécologie hôpital Antoine Béclère Paris, Reinier de Graaf Hospital, Hospital La Fe [Valencia, Spain], Azienda ospedaliera universitaria integrata di Verona [Italy], University Hospital of the Ludwig-Maximilians University, University of Bern [Bern, Switzerland] (University Hospital Bern ), King's College Hospital (KCH), Hospital Universitario De Canarias, Service d'urologie [Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Normandie Université (NU)-Normandie Université (NU), University Hospitals Leuven [Leuven], Georg-August-University [Göttingen], Södra Älvsborgs Hospital [Borås], University College of Borås, Radboudumc Nijmegen [The Netherlands], Medizinische Universität Wien = Medical University of Vienna, University of Sheffield [Sheffield], Helios Klinikum [Erfurt], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), Vita-Salute San Raffaele University and Center for Translational Genomics and Bioinformatics, Paracelsus Medizinische Privatuniversität = Paracelsus Medical University (PMU), Marmara University [Kadıköy - İstanbul], Department of urology, Università Vita-Salute San Raffaele, Universitätsklinikum Carl Gustav Carus, University of Aberdeen, Chapple, Christopher R., Cruz, Francisco, Deffieux, Xavier, Milani, Alfredo L., Arlandis, Salvador, Artibani, Walter, Bauer, Ricarda M., Burkhard, Fiona, Cardozo, Linda, Castro-Diaz, David, Cornu, Jean Nicola, Deprest, Jan, Gunnemann, Alfon, Gyhagen, Maria, Heesakkers, John, Koelbl, Heinz, Macneil, Sheila, Naumann, Gert, Roovers, Jan-Paul W. R., Salvatore, Stefano, Sievert, Karl-Dietrich, Tarcan, Tufan, Van der Aa, Frank, Montorsi, Francesco, Wirth, Manfred, and Abdel-Fattah, Mohamed
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Male ,Stress incontinence ,Time Factors ,Urinary Incontinence, Stress ,030232 urology & nephrology ,Urinary incontinence ,Urologic Surgical Procedure ,[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,Abdominal wall ,0302 clinical medicine ,Urinary Incontinence, Stre ,Societies, Medical ,030219 obstetrics & reproductive medicine ,Chronic pain ,3. Good health ,Europe ,medicine.anatomical_structure ,Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] ,Treatment Outcome ,Consensus statement ,Vagina ,Urologic Surgical Procedures ,Female ,medicine.symptom ,Polypropylene ,Human ,medicine.medical_specialty ,Consensus ,Urologic Surgical Procedures, Male ,Time Factor ,Urology ,Consensu ,Polypropylenes ,Prosthesis Design ,Pelvic Organ Prolapse ,Sling (weapon) ,03 medical and health sciences ,medicine ,Humans ,Suburethral Sling ,Mesh ,Suburethral Slings ,Stress urinary incontinence ,business.industry ,Surgical Mesh ,medicine.disease ,Surgery ,Pelvic organ prolapse ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Surgical mesh ,Gynecology ,business - Abstract
Context: Surgical nonautologous meshes have been used for several decades to repair abdominal wall herniae. Implantable materials have been adopted for the treatment of female and male stress urinary incontinence (SUI) and female pelvic organ prolapse (POP). Objective: A consensus review of existing data based on published meta-analyses and reviews. Evidence acquisition: This document summarises the deliberations of a consensus group meeting convened by the European Association of Urology (EAU) and the European Urogynecological Association, to explore the current evidence relating to the use of polypropylene (PP) materials used for the treatment of SUI and POP, with reference to the 2016 EAU guidelines (European Association of Urology 2016), the European Commission's SCENIHR report on the use of surgical meshes (SCENIHR 2015), other available high-quality evidence, guidelines, and national recommendations. Evidence synthesis: Current data suggest that the use of nonautologous durable materials in surgery has well-established benefits but significant risks, which are specific to the condition and location they are used for. Various graft-related complications have been described-such as infection, chronic pain including dyspareunia, exposure in the vagina, shrinkage, erosion into other organs of xenografts, synthetic PP tapes (used in SUI), and meshes (used in POP)-which differ from the complications seen with abdominal herniae. Conclusions: When considering surgery for SUI, it is essential to evaluate the available options, which may include synthetic midurethral slings (MUSs) using PP tapes, bulking agents, colposuspension, and autologous sling surgery. The use of synthetic MUSs for surgical treatment of SUI in both male and female patients has good efficacy and acceptable morbidity. Synthetic mesh for POP should be used only in complex cases with recurrent prolapse in the same compartment and restricted to those surgeons with appropriate training who are working in multidisciplinary referral centres. Patient summary: Synthetic slings can be safely used in the surgical treatment of stress incontinence in both male and female patients. Patients need to be aware of the alternative therapy and potential risks and complications of this therapy. Synthetic mesh for treating prolapse should be used only in complex cases with recurrent prolapse in specialist referral centres. (C) 2017 European Association of Urology. Published by Elsevier B.V. All rights reserved
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- 2017
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24. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
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Zhou, B. and Bentham, J. and Di Cesare, M. and Bixby, H. and Danaei, G. and Cowan, M.J. and Paciorek, C.J. and Singh, G. and Hajifathalian, K. and Bennett, J.E. and Taddei, C. and Bilano, V. and Carrillo-Larco, R.M. and Djalalinia, S. and Khatibzadeh, S. and Lugero, C. and Peykari, N. and Zhang, W.Z. and Lu, Y. and Stevens, G.A. and Riley, L.M. and Bovet, P. and Elliott, P. and Gu, D. and Ikeda, N. and Jackson, R.T. and Joffres, M. and Kengne, A.P. and Laatikainen, T. and Lam, T.H. and Laxmaiah, A. and Liu, J. and Miranda, J.J. and Mondo, C.K. and Neuhauser, H.K. and Sundström, J. and Smeeth, L. and Sorić, M. and Woodward, M. and Ezzati, M. and Abarca-Gómez, L. and Abdeen, Z.A. and Rahim, H.A. and Abu-Rmeileh, N.M. and Acosta-Cazares, B. and Adams, R. and Aekplakorn, W. and Afsana, K. and Aguilar-Salinas, C.A. and Agyemang, C. and Ahmadvand, A. and Ahrens, W. and Al Raddadi, R. and Al Woyatan, R. and Ali, M.M. and Alkerwi, A. and Aly, E. and Amouyel, P. and Amuzu, A. and Andersen, L.B. and Anderssen, S.A. and Ängquist, L. and Anjana, R.M. and Ansong, D. and Aounallah-Skhiri, H. and Araújo, J. and Ariansen, I. and Aris, T. and Arlappa, N. and Aryal, K. and Arveiler, D. and Assah, F.K. and Assunção, M.C.F. and Avdicová, M. and Azevedo, A. and Azizi, F. and Babu, B.V. and Bahijri, S. and Balakrishna, N. and Bandosz, P. and Banegas, J.R. and Barbagallo, C.M. and Barceló, A. and Barkat, A. and Barros, A.J.D. and Barros, M.V. and Bata, I. and Batieha, A.M. and Baur, L.A. and Beaglehole, R. and Romdhane, H.B. and Benet, M. and Benson, L.S. and Bernabe-Ortiz, A. and Bernotiene, G. and Bettiol, H. and Bhagyalaxmi, A. and Bharadwaj, S. and Bhargava, S.K. and Bi, Y. and Bikbov, M. and Bjerregaard, P. and Bjertness, E. and Björkelund, C. and Blokstra, A. and Bo, S. and Bobak, M. and Boeing, H. and Boggia, J.G. and Boissonnet, C.P. and Bongard, V. and Braeckman, L. and Brajkovich, I. and Branca, F. and Breckenkamp, J. and Brenner, H. and Brewster, L.M. and Bruno, G. and Bueno-de-Mesquita, H.B. and Bugge, A. and Burns, C. and Bursztyn, M. and de León, A.C. and Cacciottolo, J. and Cameron, C. and Can, G. and Cândido, A.P.C. and Capuano, V. and Cardoso, V.C. and Carlsson, A.C. and Carvalho, M.J. and Casanueva, F.F. and Casas, J.-P. and Caserta, C.A. and Chamukuttan, S. and Chan, A.W. and Chan, Q. and Chaturvedi, H.K. and Chaturvedi, N. and Chen, C.-J. and Chen, F. and Chen, H. and Chen, S. and Chen, Z. and Cheng, C.-Y. and Dekkaki, I.C. and Chetrit, A. and Chiolero, A. and Chiou, S.-T. and Chirita-Emandi, A. and Cho, B. and Cho, Y. and Chudek, J. and Cifkova, R. and Claessens, F. and Clays, E. and Concin, H. and Cooper, C. and Cooper, R. and Coppinger, T.C. and Costanzo, S. and Cottel, D. and Cowell, C. and Craig, C.L. and Crujeiras, A.B. and Cruz, J.J. and D'Arrigo, G. and d'Orsi, E. and Dallongeville, J. and Damasceno, A. and Dankner, R. and Dantoft, T.M. and Dauchet, L. and De Backer, G. and De Bacquer, D. and de Gaetano, G. and De Henauw, S. and De Smedt, D. and Deepa, M. and Dehghan, A. and Delisle, H. and Deschamps, V. and Dhana, K. and Di Castelnuovo, A.F. and Dias-da-Costa, J.S. and Diaz, A. and Dickerson, T.T. and Do, H.T.P. and Donfrancesco, C. and Dobson, A.J. and Donoso, S.P. and Döring, A. and Doua, K. and Drygas, W. and Dulskiene, V. and Džakula, A. and Dzerve, V. and Dziankowska-Zaborszczyk, E. and Ekelund, U. and El Ati, J. and Ellert, U. and Elosua, R. and Erasmus, R.T. and Erem, C. and Eriksen, L. and Escobedo-de la Peña, J. and Evans, A. and Faeh, D. and Fall, C.H. and Farzadfar, F. and Felix-Redondo, F.J. and Ferguson, T.S. and Fernández-Bergés, D. and Ferrante, D. and Ferrari, M. and Ferreccio, C. and Ferrieres, J. and Finn, J.D. and Fischer, K. and Föger, B. and Foo, L.H. and Forslund, A.-S. and Forsner, M. and Fortmann, S.P. and Fouad, H.M. and Francis, D.K. and do Carmo Franco, M. and Franco, O.H. and Frontera, G. and Fuchs, F.D. and Fuchs, S.C. and Fujita, Y. and Furusawa, T. and Gaciong, Z. and Gareta, D. and Garnett, S.P. and Gaspoz, J.-M. and Gasull, M. and Gates, L. and Gavrila, D. and Geleijnse, J.M. and Ghasemian, A. and Ghimire, A. and Giampaoli, S. and Gianfagna, F. and Giovannelli, J. and Goldsmith, R.A. and Gonçalves, H. and Gross, M.G. and González Rivas, J.P. and Gottrand, F. and Graff-Iversen, S. and Grafnetter, D. and Grajda, A. and Gregor, R.D. and Grodzicki, T. and Grøntved, A. and Gruden, G. and Grujic, V. and Guan, O.P. and Gudnason, V. and Guerrero, R. and Guessous, I. and Guimaraes, A.L. and Gulliford, M.C. and Gunnlaugsdottir, J. and Gunter, M. and Gupta, P.C. and Gureje, O. and Gurzkowska, B. and Gutierrez, L. and Gutzwiller, F. and Hadaegh, F. and Halkjær, J. and Hambleton, I.R. and Hardy, R. and Harikumar, R. and Hata, J. and Hayes, A.J. and He, J. and Hendriks, M.E. and Henriques, A. and Cadena, L.H. and Herqutanto and Herrala, S. and Heshmat, R. and Hihtaniemi, I.T. and Ho, S.Y. and Ho, S.C. and Hobbs, M. and Hofman, A. and Dinc, G.H. and Hormiga, C.M. and Horta, B.L. and Houti, L. and Howitt, C. and Htay, T.T. and Htet, A.S. and Hu, Y. and Huerta, J.M. and Husseini, A.S. and Huybrechts, I. and Hwalla, N. and Iacoviello, L. and Iannone, A.G. and Ibrahim, M.M. and Ikram, M.A. and Irazola, V.E. and Islam, M. and Ivkovic, V. and Iwasaki, M. and Jacobs, J.M. and Jafar, T. and Jamrozik, K. and Janszky, I. and Jasienska, G. and Jelakovic, B. and Jiang, C.Q. and Johansson, M. and Jonas, J.B. and Jørgensen, T. and Joshi, P. and Juolevi, A. and Jurak, G. and Jureša, V. and Kaaks, R. and Kafatos, A. and Kalter-Leibovici, O. and Kamaruddin, N.A. and Kasaeian, A. and Katz, J. and Kauhanen, J. and Kaur, P. and Kavousi, M. and Kazakbaeva, G. and Keil, U. and Boker, L.K. and Keinänen-Kiukaanniemi, S. and Kelishadi, R. and Kemper, H.C.G. and Kersting, M. and Key, T. and Khader, Y.S. and Khalili, D. and Khang, Y.-H. and Khaw, K.-T. and Kiechl, S. and Killewo, J. and Kim, J. and Klumbiene, J. and Kolle, E. and Kolsteren, P. and Korrovits, P. and Koskinen, S. and Kouda, K. and Koziel, S. and Kristensen, P.L. and Krokstad, S. and Kromhout, D. and Kruger, H.S. and Kubinova, R. and Kuciene, R. and Kuh, D. and Kujala, U.M. and Kula, K. and Kulaga, Z. and Krishna Kumar, R. and Kurjata, P. and Kusuma, Y.S. and Kuulasmaa, K. and Kyobutungi, C. and Lachat, C. and Landrove, O. and Lanska, V. and Lappas, G. and Larijani, B. and Laugsand, L.E. and Le Nguyen Bao, K. and Le, T.D. and Leclercq, C. and Lee, J. and Lee, J. and Lehtimäki, T. and Rampal, L. and León-Muñoz, L.M. and Levitt, N.S. and Li, Y. and Lilly, C.L. and Lim, W.-Y. and Lima-Costa, M.F. and Lin, H.-H. and Lin, X. and Linneberg, A. and Lissner, L. and Litwin, M. and Lorbeer, R. and Lotufo, P.A. and Lozano, J.E. and Luksiene, D. and Lundqvist, A. and Lunet, N. and Lytsy, P. and Ma, G. and Ma, J. and Machado-Coelho, G.L.L. and Machi, S. and Maggi, S. and Magliano, D.J. and Majer, M. and Makdisse, M. and Malekzadeh, R. and Malhotra, R. and Rao, K.M. and Malyutina, S. and Manios, Y. and Mann, J.I. and Manzato, E. and Margozzini, P. and Marques-Vidal, P. and Marrugat, J. and Martorell, R. and Mathiesen, E.B. and Matijasevich, A. and Matsha, T.E. and Mbanya, J.C.N. and McDonald Posso, A.J. and McFarlane, S.R. and McGarvey, S.T. and McLachlan, S. and McLean, R.M. and McNulty, B.A. and MdKhir, A.S. and Mediene-Benchekor, S. and Medzioniene, J. and Meirhaeghe, A. and Meisinger, C. and Menezes, A.M.B. and Menon, G.R. and Meshram, I.I. and Metspalu, A. and Mi, J. and Mikkel, K. and Miller, J.C. and Miquel, J.F. and Mišigoj-Durakovic, M. and Mohamed, M.K. and Mohammad, K. and Mohammadifard, N. and Mohan, V. and Mohd Yusoff, M.F. and Møller, N.C. and Molnár, D. and Momenan, A. and Monyeki, K.D.K. and Moreira, L.B. and Morejon, A. and Moreno, L.A. and Morgan, K. and Moschonis, G. and Mossakowska, M. and Mota, J. and Mostafa, A. and Motlagh, M.E. and Motta, J. and Muiesan, M.L. and Müller-Nurasyid, M. and Murphy, N. and Mursu, J. and Musil, V. and Nagel, G. and Naidu, B.M. and Nakamura, H. and Námešná, J. and Nang, E.E.K. and Nangia, V.B. and Narake, S. and Navarrete-Muñoz, E.M. and Ndiaye, N.C. and Neal, W.A. and Nenko, I. and Nervi, F. and Nguyen, N.D. and Nguyen, Q.N. and Nieto-Martínez, R.E. and Niiranen, T.J. and Ning, G. and Ninomiya, T. and Nishtar, S. and Noale, M. and Noboa, O.A. and Noorbala, A.A. and Norat, T. and Noto, D. and Al Nsour, M. and O'Reilly, D. and Oh, K. and Olinto, M.T.A. and Oliveira, I.O. and Omar, M.A. and Onat, A. and Ordunez, P. and Osmond, C. and Ostojic, S.M. and Otero, J.A. and Overvad, K. and Owusu-Dabo, E. and Paccaud, F.M. and Padez, C. and Pahomova, E. and Pajak, A. and Palli, D. and Palmieri, L. and Panda-Jonas, S. and Panza, F. and Papandreou, D. and Parnell, W.R. and Parsaeian, M. and Pecin, I. and Pednekar, M.S. and Peer, N. and Peeters, P.H. and Peixoto, S.V. and Pelletier, C. and Peltonen, M. and Pereira, A.C. and Pérez, R.M. and Peters, A. and Petkeviciene, J. and Pham, S.T. and Pigeot, I. and Pikhart, H. and Pilav, A. and Pilotto, L. and Pitakaka, F. and Plans-Rubió, P. and Polakowska, M. and Polašek, O. and Porta, M. and Portegies, M.L.P. and Pourshams, A. and Pradeepa, R. and Prashant, M. and Price, J.F. and Puiu, M. and Punab, M. and Qasrawi, R.F. and Qorbani, M. and Radic, I. and Radisauskas, R. and Rahman, M. and Raitakari, O. and Raj, M. and Rao, S.R. and Ramachandran, A. and Ramos, E. and Rampal, S. and Rangel Reina, D.A. and Rasmussen, F. and Redon, J. and Reganit, P.F.M. and Ribeiro, R. and Riboli, E. and Rigo, F. and Rinke de Wit, T.F. and Ritti-Dias, R.M. and Robinson, S.M. and Robitaille, C. and Rodríguez-Artalejo, F. and del Cristo Rodriguez-Perez, M. and Rodríguez-Villamizar, L.A. and Rojas-Martinez, R. and Rosengren, A. and Rubinstein, A. and Rui, O. and Ruiz-Betancourt, B.S. and Russo Horimoto, A.R.V. and Rutkowski, M. and Sabanayagam, C. and Sachdev, H.S. and Saidi, O. and Sakarya, S. and Salanave, B. and Martinez, E.S. and Salmerón, D. and Salomaa, V. and Salonen, J.T. and Salvetti, M. and Sánchez-Abanto, J. and Sans, S. and Santos, D. and Santos, I.S. and dos Santos, R.N. and Santos, R. and Saramies, J.L. and Sardinha, L.B. and Margolis, G.S. and Sarrafzadegan, N. and Saum, K.-U. and Savva, S.C. and Scazufca, M. and Schargrodsky, H. and Schneider, I.J. and Schultsz, C. and Schutte, A.E. and Sen, A. and Senbanjo, I.O. and Sepanlou, S.G. and Sharma, S.K. and Shaw, J.E. and Shibuya, K. and Shin, D.W. and Shin, Y. and Siantar, R. and Sibai, A.M. and Santos Silva, D.A. and Simon, M. and Simons, J. and Simons, L.A. and Sjöström, M. and Skovbjerg, S. and Slowikowska-Hilczer, J. and Slusarczyk, P. and Smith, M.C. and Snijder, M.B. and So, H.-K. and Sobngwi, E. and Söderberg, S. and Solfrizzi, V. and Sonestedt, E. and Song, Y. and Sørensen, T.I.A. and Jérome, C.S. and Soumare, A. and Staessen, J.A. and Starc, G. and Stathopoulou, M.G. and Stavreski, B. and Steene-Johannessen, J. and Stehle, P. and Stein, A.D. and Stergiou, G.S. and Stessman, J. and Stieber, J. and Stöckl, D. and Stocks, T. and Stokwiszewski, J. and Stronks, K. and Strufaldi, M.W. and Sun, C.-A. and Sung, Y.-T. and Suriyawongpaisal, P. and Sy, R.G. and Tai, E.S. and Tammesoo, M.-L. and Tamosiunas, A. and Tang, L. and Tang, X. and Tao, Y. and Tanser, F. and Tarawneh, M.R. and Tarqui-Mamani, C.B. and Taylor, A. and Theobald, H. and Thijs, L. and Thuesen, B.H. and Tjonneland, A. and Tolonen, H.K. and Tolstrup, J.S. and Topbas, M. and Topór-Madry, R. and Tormo, M.J. and Torrent, M. and Traissac, P. and Trichopoulos, D. and Trichopoulou, A. and Trinh, O.T.H. and Trivedi, A. and Tshepo, L. and Tulloch-Reid, M.K. and Tuomainen, T.-P. and Tuomilehto, J. and Turley, M.L. and Tynelius, P. and Tzourio, C. and Ueda, P. and Ugel, E. and Ulmer, H. and Uusitalo, H.M.T. and Valdivia, G. and Valvi, D. and van der Schouw, Y.T. and Van Herck, K. and van Rossem, L. and van Valkengoed, I.G.M. and Vanderschueren, D. and Vanuzzo, D. and Vatten, L. and Vega, T. and Velasquez-Melendez, G. and Veronesi, G. and Verschuren, W.M.M. and Verstraeten, R. and Victora, C.G. and Viet, L. and Viikari-Juntura, E. and Vineis, P. and Vioque, J. and Virtanen, J.K. and Visvikis-Siest, S. and Viswanathan, B. and Vollenweider, P. and Voutilainen, S. and Vrdoljak, A. and Vrijheid, M. and Wade, A.N. and Wagner, A. and Walton, J. and Wan Mohamud, W.N. and Wang, M.-D. and Wang, Q. and Wang, Y.X. and Wannamethee, S.G. and Wareham, N. and Wederkopp, N. and Weerasekera, D. and Whincup, P.H. and Widhalm, K. and Widyahening, I.S. and Wijga, A.H. and Wiecek, A. and Wilks, R.J. and Willeit, J. and Willeit, P. and Williams, E.A. and Wilsgaard, T. and Wojtyniak, B. and Wong, T.Y. and Wong-McClure, R.A. and Woo, J. and Wu, A.G. and Wu, F.C. and Wu, S.L. and Xu, H. and Yan, W. and Yang, X. and Ye, X. and Yiallouros, P.K. and Yoshihara, A. and Younger-Coleman, N.O. and Yusoff, A.F. and Yusoff, M.F.M. and Zambon, S. and Zdrojewski, T. and Zeng, Y. and Zhao, D. and Zhao, W. and Zheng, Y. and Zimmermann, E. and Cisneros, J.Z. and Zhu, D. and Eggertsen, R. and NCD Risk Factor Collaboration (NCD-RisC), Imperial College London, United Kingdom, Middlesex University, United Kingdom, World Health Organization, Switzerland, University of California, Berkeley, United States, Tufts University, United States, Universidad Peruana Cayetano Heredia, Peru, Tehran University of Medical Sciences, Iran, Brandeis University, United States, Mulago Hospital, Uganda, Yale University, United States, University of Lausanne, Switzerland, Ministry of Health, Seychelles, National Center for Cardiovascular Diseases, China, National Institute of Health and Nutrition, Japan, University of Auckland, New Zealand, Simon Fraser University, Canada, South African Medical Research Council, South Africa, National Institute for Health and Welfare, Finland, University of Hong Kong, Hong Kong, National Institute of Nutrition, India, Capital Medical University Beijing An Zhen Hospital, China, Robert Koch Institute, Germany, Uppsala University, Sweden, London School of Hygiene and Tropical Medicine, United Kingdom, University of Zagreb, Croatia, University of Sydney, Australia, University of Oxford, United Kingdom, Caja Costarricense de Seguro Social, Costa Rica, Al-Quds University, Palestine, Qatar University, Qatar, Birzeit University, Palestine, Instituto Mexicano del Seguro Social, Mexico, The University of Adelaide, Australia, Mahidol University, Thailand, BRAC, Bangladesh, Instituto Nacional de Ciencias Médicas y Nutricion, Mexico, University of Amsterdam, Netherlands, Non-Communicable Diseases Research Center, Iran, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Germany, Ministry of Health, Saudi Arabia, Ministry of Health, Kuwait, World Health Organization Regional Office for the Eastern Mediterranean, Egypt, Luxembourg Institute of Health, Luxembourg, Lille University and Hospital, France, Sogn and Fjordane University College, Norway, Norwegian School of Sport Sciences, Norway, Bispebjerg and Frederiksberg Hospitals, Denmark, Madras Diabetes Research Foundation, India, Komfo Anokye Teaching Hospital, Ghana, National Institute of Public Health, Tunisia, University of Porto, Portugal, Norwegian Institute of Public Health, Norway, Ministry of Health Malaysia, Malaysia, Nepal Health Research Council, Nepal, Strasbourg University and Hospital, France, University of Yaoundé 1, Cameroon, Federal University of Pelotas, Brazil, Regional Authority of Public Health, Banska Bystrica, Slovakia, University of Porto Medical School, Portugal, Shahid Beheshti University of Medical Sciences, Iran, Indian Council of Medical Research, India, King Abdulaziz University, Saudi Arabia, Medical University of Gdansk, Poland, Universidad Autónoma de Madrid, Spain, University of Palermo, Italy, Pan American Health Organization, United States, Université Mohammed V de Rabat, Morocco, University of Pernambuco, Brazil, Dalhousie University, Canada, Jordan University of Science and Technology, Jordan, University Tunis El Manar, Tunisia, University Medical Science, Cuba, University of Utah School of Medicine, United States, Lithuanian University of Health Sciences, Lithuania, University of São Paulo, Brazil, B J Medical College, India, Chirayu Medical College, India, SL Jain Hospital, India, Shanghai Jiao-Tong University School of Medicine, China, Ufa Eye Research Institute, Russian Federation, University of Southern Denmark, Denmark, University of Greenland, Greenland, University of Oslo, Norway, University of Gothenburg, Sweden, National Institute for Public Health and the Environment, Netherlands, University of Turin, Italy, University College London, United Kingdom, German Institute of Human Nutrition, Germany, Universidad de la República, Uruguay, CEMIC, Argentina, Toulouse University School of Medicine, France, Ghent University, Belgium, Universidad Central de Venezuela, Venezuela, Bielefeld University, Germany, German Cancer Research Center, Germany, Cork Institute of Technology, Ireland, Hadassah-Hebrew University Medical Center, Israel, Universidad de La Laguna, Spain, University of Malta, Malta, Canadian Fitness and Lifestyle Research Institute, Canada, Istanbul University, Turkey, Universidade Federal de Juiz de Fora, Brazil, Cardiologia di Mercato S Severino, Italy, Karolinska Institutet, Sweden, Santiago de Compostela University, Spain, Associazione Calabrese di Epatologia, Italy, India Diabetes Research Foundation, India, Duke-NUS Medical School, Singapore, National Institute of Medical Statistics, India, Academia Sinica, Taiwan, Capital Institute of Pediatrics, China, Duke University, United States, Kailuan General Hospital, China, The Gertner Institute for Epidemiology and Health Policy Research, Israel, Lausanne University Hospital, Switzerland, Ministry of Health and Welfare, Taiwan, Victor Babeș University of Medicine and Pharmacy Timisoara, Romania, Seoul National University College of Medicine, South Korea, Korea Centers for Disease Control and Prevention, South Korea, Medical University of Silesia, Poland, Charles University in Prague, Czech Republic, Katholieke Universiteit Leuven, Belgium, Agency for Preventive and Social Medicine, Austria, University of Southampton, United Kingdom, IRCCS Istituto Neurologico Mediterraneo Neuromed, Italy, Institut Pasteur de Lille, France, Westmead University of Sydney, Australia, CIBEROBN, Spain, National Council of Research, Italy, Federal University of Santa Catarina, Brazil, Eduardo Mondlane University, Mozambique, Research Centre for Prevention and Health, Denmark, Lille University Hospital, France, Erasmus Medical Center Rotterdam, Netherlands, University of Montreal, Canada, French Public Health Agency, France, Universidade do Vale do Rio dos Sinos, Brazil, National Council of Scientific and Technical Research, Argentina, National Institute of Nutrition, Viet Nam, University of Queensland, Australia, Istituto Superiore di Sanità, Italy, Universidad de Cuenca, Ecuador, Helmholtz Zentrum München, Germany, Ministère de la Santé et de la Lutte Contre le Sida, Cote d'Ivoire, The Cardinal Wyszynski Institute of Cardiology, Poland, University of Latvia, Latvia, Medical University of Łodz, Poland, National Institute of Nutrition and Food Technology, Tunisia, Institut Hospital del Mar d'Investigacions Mèdiques, Spain, University of Stellenbosch, South Africa, Karadeniz Technical University, Turkey, The Queen's University of Belfast, United Kingdom, University of Zurich, Switzerland, Centro de Salud Villanueva Norte, Spain, The University of the West Indies, Jamaica, Hospital Don Benito-Villanueva de la Serena, Spain, Ministry of Health, Argentina, Council for Agricultural Research and Economics, Italy, Pontificia Universidad Católica de Chile, Chile, University of Manchester, United Kingdom, University of Tartu, Estonia, Universiti Sains Malaysia, Malaysia, Umeå University, Sweden, Dalarna University, Sweden, Stanford University, United States, Federal University of São Paulo, Brazil, Hospital Universitario Son Espases, Spain, Hospital de Clinicas de Porto Alegre, Brazil, Universidade Federal do Rio Grande do Sul, Brazil, Kindai University, Japan, Kyoto University, Japan, Medical University of Warsaw, Poland, University of KwaZulu-Natal, South Africa, Geneva University Hospitals, Switzerland, CIBER en Epidemiología y Salud Pública, Spain, Australian Bureau of Statistics, Australia, Murcia Regional Health Council, Spain, Wageningen University, Netherlands, Endocrinology and Metabolism Research Institute, Iran, B P Koirala Institute of Health Sciences, Nepal, University of Insubria, Italy, Ministry of Health, Israel, Universidad Politécnica de Madrid, Spain, The Andes Clinic of Cardio-Metabolic Studies, Venezuela, Université de Lille 2, France, Institute for Clinical and Experimental Medicine, Czech Republic, The Children's Memorial Health Institute, Poland, Jagiellonian University Medical College, Poland, University of Novi Sad, Serbia, Singapore Eye Research Institute, Singapore, University of Iceland, Iceland, Universidad Icesi, Colombia, State University of Montes Claros, Brazil, King's College London, United Kingdom, Icelandic Heart Association, Iceland, Healis-Sekhsaria Institute for Public Health, India, University of Ibadan, Nigeria, Institute for Clinical Effectiveness and Health Policy, Argentina, Danish Cancer Society Research Centre, Denmark, The University of the West Indies, Barbados, Kyushu University, Japan, Tulane University, United States, Academic Medical Center Amsterdam, Netherlands, National Institute of Public Health, Mexico, Universitas Indonesia, Indonesia, Oulu University Hospital, Finland, Chronic Diseases Research Center, Iran, The Chinese University of Hong Kong, Hong Kong, University of Western Australia, Australia, Celal Bayar University, Turkey, Fundación Oftalmológica de Santander, Colombia, Universidade Federal de Pelotas, Brazil, University of Oran 1, Algeria, University of Public Health, Myanmar, Ministry of Health, Myanmar, Peking University, China, International Agency for Research on Cancer, France, American University of Beirut, Lebanon, Cairo University, Egypt, Aga Khan University, Pakistan, UHC Zagreb, Croatia, Niigata University, Japan, Hadassah University Medical Center, Israel, Norwegian University of Science and Technology, Norway, University of Zagreb School of Medicine, Croatia, Guangzhou 12th Hospital, China, Ruprecht-Karls-University of Heidelberg, Germany, World Health Organization Country Office, India, University of Ljubljana, Slovenia, University of Crete, Greece, Universiti Kebangsaan Malaysia, Malaysia, Johns Hopkins Bloomberg School of Public Health, United States, University of Eastern Finland, Finland, National Institute of Epidemiology, India, University of Münster, Germany, Israel Center for Disease Control, Israel, Research Institute for Primordial Prevention of Non-Communicable Disease, Iran, VU University Medical Center, Netherlands, Research Institute of Child Nutrition, Germany, Seoul National University, South Korea, University of Cambridge, United Kingdom, Medical University of Innsbruck, Austria, Muhimbili University of Health and Allied Sciences, Tanzania, National Cancer Center, South Korea, Institute of Tropical Medicine, Belgium, Tartu University Clinics, Estonia, Polish Academy of Sciences Anthropology Unit in Wroclaw, Poland, University of Groningen, Netherlands, North-West University, South Africa, National Institute of Public Health, Czech Republic, University of Jyväskylä, Finland, Amrita Institute of Medical Sciences, India, All India Institute of Medical Sciences, India, African Population and Health Research Center, Kenya, Ministerio de Salud Pública, Cuba, Sahlgrenska Academy, Sweden, Endocrinology and Metabolism Research Center, Iran, Food and Agriculture Organization, Italy, National University of Singapore, Singapore, Tampere University Hospital, Finland, Universiti Putra Malaysia, Malaysia, University of Cape Town, South Africa, West Virginia University, United States, Oswaldo Cruz Foundation Rene Rachou Research Institute, Brazil, National Taiwan University, Taiwan, University of Chinese Academy of Sciences, China, University Medicine Greifswald, Germany, Consejería de Sanidad Junta de Castilla y León, Spain, Universidade do Porto, Portugal, University of Uppsala, Sweden, Universidade Federal de Ouro Preto, Brazil, The Jikei University School of Medicine, Japan, National Research Council, Italy, Baker IDI Heart and Diabetes Institute, Australia, Hospital Israelita Albert Einstein, Brazil, Institute of Internal and Preventive Medicine, Russian Federation, Harokopio University, Greece, University of Otago, New Zealand, University of Padova, Italy, Emory University, United States, UiT The Arctic University of Norway, Norway, Cape Peninsula University of Technology, South Africa, Gorgas Memorial Institute of Health Studies, Panama, Brown University, United States, University of Edinburgh, United Kingdom, University College Dublin, Ireland, Penang Medical College, Malaysia, Institut National de la Santé et de la Recherche Médicale, France, Ain Shams University, Egypt, Hypertension Research Center, Iran, University of Pécs, Hungary, University of Limpopo, South Africa, Universidad de Zaragoza, Spain, RCSI Dublin, Ireland, International Institute of Molecular and Cell Biology, Poland, Ahvaz Jundishapur University of Medical Sciences, Iran, Gorgas Memorial Institute of Public Health, Panama, University of Brescia, Italy, Ulm University, Germany, Institute of Public Health, Malaysia, Kobe University, Japan, Suraj Eye Institute, India, INSERM, France, The University of Pharmacy and Medicine of Ho Chi Minh City, Viet Nam, Hanoi Medical University, Viet Nam, Universidad Centro-Occidental Lisandro Alvarado, Venezuela, Heartfile, Pakistan, Eastern Mediterranean Public Health Network, Jordan, Aarhus University, Denmark, Kwame Nkrumah University of Science and Technology, Ghana, Institute for Social and Preventive Medicine, Switzerland, University of Coimbra, Portugal, Cancer Prevention and Research Institute, Italy, University of Bari, Italy, Zayed University, United Arab Emirates, University Medical Center Utrecht, Netherlands, Public Health Agency of Canada, Canada, Heart Institute, Brazil, National Institute of Hygiene, Epidemiology and Microbiology, Cuba, Vietnam National Heart Institute, Viet Nam, Federal Ministry of Health, Bosnia and Herzegovina, Cardiovascular Prevention Centre Udine, Italy, University of New South Wales, Australia, Public Health Agency of Catalonia, Spain, University of Split, Croatia, Alborz University of Medical Sciences, Iran, Turku University Hospital, Finland, Julius Centre University of Malaya, Malaysia, University of Valencia, Spain, University of the Philippines, Philippines, Minas Gerais State Secretariat for Health, Brazil, Health Center San Agustín, Spain, PharmAccess Foundation, Netherlands, Canarian Health Service, Spain, Universidad Industrial de Santander, Colombia, Instituto Nacional de Salud Pública, Mexico, University of Madeira, Portugal, Sitaram Bhartia Institute of Science and Research, India, Marmara University, Turkey, University of Helsinki, Finland, National Institute of Health, Peru, Catalan Department of Health, Spain, Universidade de Lisboa, Portugal, University of Sao Paulo Clinics Hospital, Brazil, South Karelia Social and Health Care District, Finland, Robert Koch Institut, Germany, Isfahan Cardiovascular Research Center, Iran, Research and Education Institute of Child Health, Cyprus, Hospital Italiano de Buenos Aires, Argentina, Lagos State University College of Medicine, Nigeria, Digestive Diseases Research Institute, Iran, The University of Tokyo, Japan, St Vincent's Hospital, Australia, Lund University, Sweden, University of Copenhagen, Denmark, Institut Régional de Santé Publique, Benin, University of Bordeaux, France, University of Leuven, Belgium, Heart Foundation, Australia, Bonn University, Germany, Sotiria Hospital, Greece, National Institute of Public Health-National Institute of Hygiene, Poland, Fu Jen Catholic University, Taiwan, Ministry of Health, Jordan, IB-SALUT Area de Salut de Menorca, Spain, Institut de Recherche pour le Développement, France, Harvard T H Chan School of Public Health, United States, Hellenic Health Foundation, Greece, Government Medical College, India, Sefako Makgatho Health Science University, South Africa, Dasman Diabetes Institute, Kuwait, Ministry of Health, New Zealand, University of Tampere Tays Eye Center, Finland, Centro di Prevenzione Cardiovascolare Udine, Italy, Universidade Federal de Minas Gerais, Brazil, Finnish Institute of Occupational Health, Finland, Universidad Miguel Hernandez, Spain, Centre for Research in Environmental Epidemiology, Spain, University of the Witwatersrand, South Africa, University of Strasbourg, France, University College Cork, Ireland, Institute for Medical Research, Malaysia, Xinjiang Medical University, China, Beijing Tongren Hospital, China, St George's, University of London, United Kingdom, Medical University of Vienna, Austria, Institute of Food and Nutrition Development of Ministry of Agriculture, China, Children's Hospital of Fudan University, China, Chinese Center for Disease Control and Prevention, China, University of Cyprus, Cyprus, Ministry of Health, Malaysia, and Inner Mongolia Medical University, China
- Abstract
Background Raised blood pressure is an important risk factor for cardiovascular diseases and chronic kidney disease. We estimated worldwide trends in mean systolic and mean diastolic blood pressure, and the prevalence of, and number of people with, raised blood pressure, defined as systolic blood pressure of 140 mm Hg or higher or diastolic blood pressure of 90 mm Hg or higher. Methods For this analysis, we pooled national, subnational, or community population-based studies that had measured blood pressure in adults aged 18 years and older. We used a Bayesian hierarchical model to estimate trends from 1975 to 2015 in mean systolic and mean diastolic blood pressure, and the prevalence of raised blood pressure for 200 countries. We calculated the contributions of changes in prevalence versus population growth and ageing to the increase in the number of adults with raised blood pressure. Findings We pooled 1479 studies that had measured the blood pressures of 19·1 million adults. Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. Mean systolic and mean diastolic blood pressure decreased substantially from 1975 to 2015 in high-income western and Asia Pacific countries, moving these countries from having some of the highest worldwide blood pressure in 1975 to the lowest in 2015. Mean blood pressure also decreased in women in central and eastern Europe, Latin America and the Caribbean, and, more recently, central Asia, Middle East, and north Africa, but the estimated trends in these super-regions had larger uncertainty than in high-income super-regions. By contrast, mean blood pressure might have increased in east and southeast Asia, south Asia, Oceania, and sub-Saharan Africa. In 2015, central and eastern Europe, sub-Saharan Africa, and south Asia had the highest blood pressure levels. Prevalence of raised blood pressure decreased in high-income and some middle-income countries; it remained unchanged elsewhere. The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries. The global increase in the number of adults with raised blood pressure is a net effect of increase due to population growth and ageing, and decrease due to declining age-specific prevalence. Interpretation During the past four decades, the highest worldwide blood pressure levels have shifted from high-income countries to low-income countries in south Asia and sub-Saharan Africa due to opposite trends, while blood pressure has been persistently high in central and eastern Europe. Funding Wellcome Trust. © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license
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- 2017
25. O historii i wolności: ‘rewizjonizm’ Bronisława Baczki
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Helder Mendes Baiao, University of Lausanne, and Dr. Helder Mendes Baiao (University of Lausanne) achieved a PhD in Switzerland at University of Lausanne under Professor François Rosset’s supervision. His PhD is entitled Citizen Dreams. Myths and Utopias in the 18th-Century French-speaking Switzerland. During 2015-2016, Dr. Mendes Baiao was a Research Fellow at University of Durham (UK) where he worked under Dr. Thomas Wynn’s supervision for the Voltaire Foundation. He has just started a postdoc research at University of Porto (Portugal) entitled Presence of Portugal in 18th-Century French literature. His fields of research are related to utopian thought, Jean-Jacques Rousseau and the history of the Imaginary.
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‘Revisionism’ ,Enlightenment ,rewolucja ,Jean-Jacques Rousseau ,marksizm ,Warsaw School of history of Ideas ,rewizjonizm’ ,revolution ,Leszek Kołakowski ,utopia ,Oświecenie ,Marxism ,Bronisław Baczko ,Warszawska Szkoła Historii Idei - Abstract
The ‘Warsaw School of History of Ideas’ is the name given to a ‘revisionist think tank’ which was led by the historian Bronisław Baczko from 1956 to 1968 in Communist Poland. This group reunited scholars like Leszek Kołakowski or Krzysztof Pomian around questions related to political believes, theological conceptions or utopian thought. Expelled from the University, B. Baczko left Poland and seek shelter in Geneva where he became a Professor of history of Ideas and historiography. In his new home, he developed an original vision on Enlightenment and the French Revolution ‘Warszawska Szkoła Historii Idei’ to nazwa nadana ‘rewizjonistycznemu think tankowi’ w komunistycznej Polsce, któremu od 1956 do 1968 przewodził historyk Bronisław Baczko. Do grupy tej należeli badacze tacy jak Leszek Kołakowski czy Krzysztof Pomian, dyskutujący takie zagadnienia, jak przekonania polityczne, pojęcia teologiczne czy myśl utopijna. Wyrzucony z Uniwersytetu, Baczko opuścił Polskę i schronił się w Genewie, gdzie został profesorem historii idei i historiografii. W swoim nowym domu wypracował oryginalna wizję Oświecenia i Rewolucji Francuskiej. Publikacja została sfinansowana ze środków Ministerstwa Nauki i Szkolnictwa Wyższego w ramach programu Narodowego Programu Rozwoju Humanistyki przyznanych na podstawie decyzji 0014/NPRH4/H3b/83/2016 - projekt „Przygotowanie i publikacja dwóch anglojęzycznych numerów monograficznych Internetowego Magazynu Filozoficznego HYBRIS” (3bH 15 0014 83).
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- 2017
26. Scientific Workflow Scheduling with Provenance Support in Multisite Cloud
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Patrick Valduriez, Ji Liu, Esther Pacitti, Marta Mattoso, Institut de Biologie Computationnelle (IBC), Institut National de la Recherche Agronomique (INRA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Microsoft Research - Inria Joint Centre (MSR - INRIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Microsoft Research Laboratory Cambridge-Microsoft Corporation [Redmond, Wash.], Scientific Data Management (ZENITH), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), COPPE - Instituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia (COPPE-UFRJ), Universidade Federal do Rio de Janeiro [Rio de Janeiro] (UFRJ), Microsoft, Faculty of Engineering of the University of Porto, Portugal, Equipe associée FAPERJ-Inria MUSIC, European Project: 689772,H2020 Pilier Industrial Leadership,H2020-EUB-2015,HPC4E(2015), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Inria Sophia Antipolis - Méditerranée (CRISAM), Instituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia (COPPE-UFRJ), and Universidade Federal do Rio de Janeiro (UFRJ)
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Multisite cloud ,[INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB] ,Database ,Computer science ,business.industry ,Scheduling ,Distributed computing ,ComputingMilieux_PERSONALCOMPUTING ,Scientific workflow ,Cloud computing ,02 engineering and technology ,ACM: C.: Computer Systems Organization/C.1: PROCESSOR ARCHITECTURES/C.1.4: Parallel Architectures/C.1.4.0: Distributed architectures ,computer.software_genre ,Execution time ,Scheduling (computing) ,Workflow ,020204 information systems ,Scientific workflow management system ,0202 electrical engineering, electronic engineering, information engineering ,Workflow scheduling ,020201 artificial intelligence & image processing ,business ,computer ,Workflow management system ,Parallel execution - Abstract
International audience; Recently, some Scientific Workflow Management Systems (SWfMSs) with provenance support (e.g. Chiron) have been deployed in the cloud. However, they typically use a single cloud site. In this paper, we consider a multisite cloud, where the data and computing resources are distributed at different sites (possibly in different regions). Based on a multisite architecture of SWfMS, i.e. multisite Chiron, we propose a multisite task scheduling algorithm that considers the time to generate provenance data. We performed an experimental evaluation of our algorithm using Microsoft Azure multisite cloud and two real-life scientific workflows, i.e. Buzz and Montage. The results show that our scheduling algorithm is up to 49.6% better than baseline algorithms in terms of execution time.
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- 2016
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27. Anti-Helicobacter pylori activities of natural isopentenyloxycinnamyl derivatives from Boronia pinnata
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Valérie Michel, Marie-Christine Prévost, Cécile Ribeiro da Silva, Francesco Epifano, Eliette Touati, Salvatore Genovese, Pathogenèse de Helicobacter, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze del Farmaco, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Microscopie Ultrastructurale (Plate-forme), This work was funded by the OdysseyRe Company. C. Ribeiro da Silva received a fellowship from the Erasmus program for training students from Escola Superior de Biotecnologia, Catholic University of Porto (Portugal) under the EC’s Leonardo program., and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
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Male ,Plant Science ,MESH: Helicobacter pylori/growth & development ,Bacterial growth ,Mice ,MESH: Anti-Bacterial Agents/pharmacology ,Drug Discovery ,MESH: Animals ,MESH: Microbial Sensitivity Tests ,0303 health sciences ,biology ,Chemistry ,MESH: Helicobacter Infections/drug therapy ,Stomach ,General Medicine ,Plant secondary metabolites ,Boronia pinnata ,3. Good health ,Anti-Bacterial Agents ,MESH: Helicobacter pylori/ultrastructure ,medicine.anatomical_structure ,Oxyprenylated derivatives ,MESH: Stomach/microbiology ,MESH: Microscopy, Electron, Scanning ,Microbial Sensitivity Tests ,Helicobacter pylori infection ,Mouse model ,Microbiology ,Helicobacter Infections ,MESH: Cinnamates/pharmacology ,03 medical and health sciences ,MESH: Mice, Inbred C57BL ,In vivo ,Gastric mucosa ,medicine ,MESH: Cinnamates/isolation & purification ,Animals ,MESH: Mice ,Rutaceae ,MESH: Helicobacter Infections/microbiology ,030304 developmental biology ,Pharmacology ,MESH: Rutaceae/chemistry ,Helicobacter pylori ,MESH: Anti-Bacterial Agents/isolation & purification ,030306 microbiology ,biology.organism_classification ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,MESH: Male ,In vitro ,Mice, Inbred C57BL ,Complementary and alternative medicine ,Cinnamates ,Anti-bacterial compounds ,MESH: Helicobacter pylori/drug effects ,[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology ,Microscopy, Electron, Scanning ,Bacterial cellular morphologies - Abstract
International audience; In this study we investigated the anti-Helicobacter pylori activity of four isopentenyloxycinnamyl derivatives from the Australian shrub Boronia pinnata Sm. (Rutaceae), structurally related to boropinic acid: (E)-3-(4-(3-methylbut-2-enyloxy)-3,5-dimethoxyphenyl)acrylaldehyde (1), boropinol C (2), boropinal (3) and boropinol A (4). In vitro growth of H. pylori strains 26695 and B128 was analyzed in liquid culture with increasing doses of these compounds. Bacterial morphology was visualized by scanning electron microscopy. The in vivo effects of the two most efficient molecules that reduced bacterial growth in vitro, compounds 3 and 4, were investigated on H. pylori gastric colonization in the mouse model. The presence of these compounds in the bacterial cultures led to alterations of bacterial surface and flagella. In vivo, both compounds 3 and 4 at 250 microM reduced significantly the ability of H pylori to colonize the gastric mucosa of mice, compared with untreated ones. These data indicate that these natural isopentenyloxycinnamyl derivatives related to boropinic acid can be considered as novel antibacterial agents with anti-H. pylori activity.
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- 2012
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28. A performant low cost wheelchair simulator for rehabilitation planning
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Alexandre Abellard, Fernando Cenal Romero, Patrick Abellard, Mohamed Moncef Ben Khelifa, Pascal Ramanantsizehena, Iadaloharivola Randria, Laboratoire de Biomodélisation et Ingénierie des Handicaps - EA 4322 ( HANDIBIO ), Université de Toulon ( UTLN ), IEEE (Industrial Electronics Society), Society of Instrument and Control Engineers (SICE-Japan), University of Porto (Portugal), Universidad de Sevilla (Spain), Laboratoire de Biomodélisation et Ingénierie des Handicaps - EA 4322 (HANDIBIO), and Université de Toulon (UTLN)
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[ SHS.INFO.AUTR ] Humanities and Social Sciences/Library and information sciences/domain_shs.info.autr ,Rehabilitation ,Wheelchair ,Computer science ,medicine.medical_treatment ,medicine ,[SHS.INFO.AUTR]Humanities and Social Sciences/Library and information sciences/domain_shs.info.autr ,Simulation ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2009
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29. Study of the effect of an electric field on the kinetics of growth of oxide layers controlled by diffusion
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Pereira, Juan Carlos, Peres, Véronique, Lillouch, Fatima, École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT), Université de Lyon, Centre National de la Recherche Scientifique (CNRS), Laboratoire Georges Friedel (LGF-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre Sciences des Processus Industriels et Naturels (SPIN-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Département Procédés de Transformations des Solides et Instrumentation (PTSI-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Vienna University of Technology, Griffith University AUSTRALIA, The University of Newcastle, K.N. Toosi University of Technology, IRAN, and University of Porto, PORTUGAL
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electric fiels ,[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,oxide ,ZrO2 - Abstract
International audience; The metals oxidation kinetics controlled by the diffusion of charged species (ions, vacancy, etc.) has been theoretically treated since the thirties. Some authors, such as Hauffe and Wagner, propose that the gas-oxide interface is electrically negative with respect to the metal-oxide one and that the potential difference between two interfaces is one of the driving forces in oxidation. In this context, the application of an external electric field, which increases or decreases this potential difference, must act as an accelerator or a retarder of the system’s reactivity. However, in the literature the results of effect of an electric field are very different and there is no agreement on its dependence on the nature of the material, the temperature and the oxidizing atmosphere. This work concerns the study of the physico-chemical behavior of a zirconium alloy (Zicaloy-4) during its exposure to high temperature under oxygen and the influence of an external voltage. In this respect, thermogravimetric experiments at 850°C with the application in situ of an electric field were carried out. The general objective is to model the diffusion of charged species in the oxidation process under the influence of an electric field, taking into account chemical and electric potential as driving forces. The results show that a constant voltage (10 Volt) improves mass gain in 20% of the sample pretreated at high temperature under helium. The voltage-free oxidation kinetics exhibit a parabolic regime up to 4 hours in isothermal stage. In contrast, oxidation with electrical potential shows mixed behavior. Optical microscopy reveals that the thickness of the ZrO2 layer is globally greater on the oxidized sample under electrical field. In addition, the negatively polarized face is more oxidized according to theory.
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- 1965
30. A new simple chronic heart failure prognostic index based on five general parameters.
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Hipólito-Reis H, Guimarães C, Elias C, Gouveia R, Madureira S, Reis C, Fonseca AM, Grijó C, Neves A, Matos M, Rocha H, Almeida J, and Lourenço P
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- Humans, Male, Female, Aged, Prognosis, Retrospective Studies, Middle Aged, Follow-Up Studies, Natriuretic Peptide, Brain blood, Chronic Disease, Biomarkers blood, Aged, 80 and over, Glomerular Filtration Rate physiology, Heart Failure blood, Heart Failure mortality, Heart Failure diagnosis, Heart Failure physiopathology
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Background: Prognostic prediction in heart failure (HF) is challenging and no single marker has proven effective. We propose an index based on B-type natriuretic peptide (BNP) and four widely available parameters., Methods: We retrospectively analyzed adult outpatients with chronic HF with systolic dysfunction followed from January 2012 to December 2020. The new proposed index was calculated based on 5 parameters measured at the index visit. BASIC index = (BNP*(age)
2 ) / (serum sodium*hemoglobin*estimated glomerular filtration rate). Patients were followed-up until January 2023; the primary endpoint was all-cause mortality. A receiver operator curve was used to assess the association of the index with outcome; a cut-off was chosen based on the curve. We used a Cox-regression analysis to determine the prognostic value of the index. Adjustments were made considering established prognostic predictors., Results: We studied 1065 patients. Mean age was 71 years, 65.8 % were male, 45.3 % had ischemic HF and 47.2 % had severe systolic dysfunction. During a 47-months median follow-up, 545 patients died (51.2 %). Median BASIC index: 11.7 (3.5-33.7). The area under the curve was 0.73 (0.70-0.76) vs 0.69 (0.66-0.72) for BNP, p < 0.001. The best cut-off value was 9.3; sensitivity = 71.4 %, specificity = 62.3 %, positive predictive value = 66.5 and negative predictive value = 67.5 %. Patients with a BASIC index above 9.3 had a multivariate-adjusted HR of all-cause mortality = 2.70 (2.20-3.22)., Conclusions: The incorporation of age, hemoglobin, serum sodium, glomerular filtration rate and BNP in an index significantly improves prognostic prediction when compared to BNP alone. Patients with a BASIC index above 9.3 have an almost 3-fold higher death-risk., Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare., (Copyright © 2025. Published by Elsevier B.V.)- Published
- 2025
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31. Introducing the Team Card: Enhancing governance for medical Artificial Intelligence (AI) systems in the age of complexity.
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Modise LM, Alborzi Avanaki M, Ameen S, Celi LA, Chen VXY, Cordes A, Elmore M, Fiske A, Gallifant J, Hayes M, Marcelo A, Matos J, Nakayama L, Ozoani E, Silverman BC, and Comeau DS
- Abstract
This paper introduces the Team Card (TC) as a protocol to address harmful biases in the development of clinical artificial intelligence (AI) systems by emphasizing the often-overlooked role of researchers' positionality. While harmful bias in medical AI, particularly in Clinical Decision Support (CDS) tools, is frequently attributed to issues of data quality, this limited framing neglects how researchers' worldviews-shaped by their training, backgrounds, and experiences-can influence AI design and deployment. These unexamined subjectivities can create epistemic limitations, amplifying biases and increasing the risk of inequitable applications in clinical settings. The TC emphasizes reflexivity-critical self-reflection-as an ethical strategy to identify and address biases stemming from the subjectivity of research teams. By systematically documenting team composition, positionality, and the steps taken to monitor and address unconscious bias, TCs establish a framework for assessing how diversity within teams impacts AI development. Studies across business, science, and organizational contexts demonstrate that diversity improves outcomes, including innovation, decision-making quality, and overall performance. However, epistemic diversity-diverse ways of thinking and problem-solving-must be actively cultivated through intentional, collaborative processes to mitigate bias effectively. By embedding epistemic diversity into research practices, TCs may enhance model performance, improve fairness and offer an empirical basis for evaluating how diversity influences bias mitigation efforts over time. This represents a critical step toward developing inclusive, ethical, and effective AI systems in clinical care. A publicly available prototype presenting our TC is accessible at https://www.teamcard.io/team/demo., Competing Interests: Leo Anthony Celi is the Editor-in-Chief of PLOS Digital Health., (Copyright: © 2025 Modise et al.. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2025
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32. The differential impact of processing speed and cognitive flexibility on cognitive emotion regulation strategies and depression.
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Castro D, Lopes P, Araújo AS, Ferreira F, Rodrigues AR, Cardoso J, Ferreira-Santos F, and Ferreira TB
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Introduction: Existing cognitive models for depression propose interactions between cognitive emotion regulation strategies (CERS) and cognitive processes. However, often oversimplify these interactions and do not accommodate the complexity of interactions. We aimed to construct and explore the micro-level properties of a network model that can integrate this complexity of the interactions and explore through computational simulations the differential impact of improvements/deterioration in cognitive flexibility and processing speed in the network., Methods: We used the Leipzig Study for Mind-Body-Emotion Interactions dataset (N = 227). The Trail Making Test assessed processing speed and cognitive flexibility, while depression and CERS were measured using the Hamilton Depression Rating Scale and the Cognitive Emotional Regulation Questionnaire. The network was estimated using the Mixed Graphical Model. Expected influence, bridge expected influence and predictability were explored as micro-level properties. Simulation procedures were done by estimating the expected network activity and comparing it with the baseline network activity., Results: CERS mediated impact of cognitive processes on depression. Processing speed emerges as a mediator with a bridging role, while cognitive flexibility seems to have a more substantial impact in overall connectivity. Rumination, exhibit high centrality, suggesting a pivotal role in the network., Limitations: Use of cross-sectional data, the assessment of depression with HDRS sum-score, as well as the low number of depressed individuals in the sample., Conclusions: The different constituents of the network seem to have different roles in the network. This might have important implications in the future for personalized and preventive interventions., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Daniel Castro reports financial support was provided by Foundation for Science and Technology. Pedro Lopes reports financial support was provided by Foundation for Science and Technology. Ana Sofia Araujo reports financial support was provided by Foundation for Science and Technology. Ana Rita Rodrigues reports financial support was provided by Foundation for Science and Technology. Joana Cardoso reports financial support was provided by Foundation for Science and Technology. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025. Published by Elsevier B.V.)
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- 2025
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33. "ZARPAR"-Educational Program for Cognitive and Behavioral Development: Results of an Experiment to Evaluate Its Impact on Antisocial and Pro-Social Behavior.
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Santos G, Santos M, Farrington DP, da Agra C, Castro J, and Cardoso CS
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- Humans, Male, Child, Female, Social Skills, Portugal, Child Development, Social Behavior, Antisocial Personality Disorder psychology, Executive Function
- Abstract
Using an experimental design and a multi-measure and multi-informant approach, the current study sought to evaluate the impact of the early developmental prevention program "ZARPAR"-an intervention designed as a social and cognitive skills training program, that seeks to promote children's behavioral adjustment. A sample of elementary school children (experimental group n = 37; control group n = 66), attending Portuguese schools, was assessed before and 6 months after the intervention on the program's key-dimensions: behavioral problems, social skills, and executive functioning. Based on parent and teacher reports, the results largely suggested that the intervention had no effect or, for some dimensions, even the existence of negative outcomes. Possible reasons for these results are discussed. The current study highlights that, despite the overwhelmingly positive message about developmental prevention programs, not all interventions work, thus reinforcing the need for rigorous evaluations, in order to enhance the success of future interventions., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2025
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34. Unveiling the Journey to Community Reintegration: Results from a Qualitative Study with Sexual Offenders on Parole.
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Cardoso AR, Quintas J, and Santos G
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After serving a prison sentence, sex offenders embark on a community reintegration process, where they usually face several barriers that might negatively affect their successful return to society. Results from semi-structured interviews conducted with sex offenders revealed that participants perceive the economic difficulties, the nature of the crime, and the stigma as the main social factors hindering their community reintegration process. Additionally, prison and parole support are described as insufficient, lacking focus on the specific needs of the participants to act as an effective help. On the contrary, housing and affective relationships were not perceived as major obstacles to a successful reintegration. These findings highlight the need for policies that promote economic opportunities, reduce stigma, and enhance both prison-based and post-release support to facilitate a more effective reintegration process., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2025
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35. First-Episode Psychosis incidence pre-, during, and post-COVID-19 pandemic: a six-year natural quasi-experimental study in South London.
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Quattrone A, Petkari E, Spinazzola E, Leung PBM, Li Z, Stewart R, Quattrone D, Di Forti M, Murray RM, and Pinto da Costa M
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Background: The COVID-19 pandemic may have been accompanied by an increased exposure to psychosis risk factors. We used a pre-during-post study design to examine variations in the incidence of First-Episode Psychosis (FEP) before, during, and after the COVID-19 pandemic in South London. We hypothesised that FEP rates rose during the pandemic and subsequently returned to pre-pandemic levels., Methods: Using the Clinical Record Interactive Search (CRIS) system, we screened individuals referred for FEP to Early Intervention Services for Psychosis (EISs) of the South London and Maudsley NHS Foundation Trust (SLaM) from 1 March 2018 to 29 February 2024. Population data for the SLaM catchment area were obtained from the Office for National Statistics (ONS). We calculated crude incidence rates and used Poisson regression models to estimate age-sex-ethnicity-adjusted variation in incidence by year (March-to-February) expressed as Incidence Rate Ratios (IRR)., Findings: A total of 3752 individuals experienced FEP during 5,487,858 person-years at risk, with a mean crude incidence of 68.4 per 100,000 person-years (95% CI: 66.2-70.6). The Poisson model showed a deviation from this mean at the peak of the COVID-19 pandemic in 2020/21, with FEP rates rising to 77.5 per 100,000 person-years (95% CI: 71.8-83.2) and similar rates in 2021/22. FEP incidence gradually returned to the pre-pandemic levels in the following years. During the COVID-19 pandemic, individuals of Black ethnicity experienced the greatest FEP increase, with an IRR of 1.45 (95% CI: 1.29-1.61) in 2020/21 and similar ratios in 2021/22. An increase was also observed in Asian individuals, with an IRR of 1.54 (95% CI: 1.20-1.88) in 2021/22, whereas no significant changes in incidence were observed for other ethnic groups across the pre-, during-, and post-pandemic periods., Interpretation: FEP incidence in South London increased during the peak of the COVID-19 pandemic, particularly among Black and Asian individuals., Funding: None., Competing Interests: RS reports receiving an educational grant from Takeda to support a PhD studentship and serving as a staff member for PhD supervision with GSK, all outside the submitted work. DQ reports receiving payments or honoraria for non-promotional lectures from Rovi, outside the submitted work. MDF reports receiving payments or honoraria for non-promotional lectures from Recordati, outside the submitted work. RMM reports consultancy roles on advisory boards for Merck, AbbVie, and Boehringer, and payments or honoraria for non-promotional lectures from Recordati and Viatris, all outside the submitted work. All other authors report no disclosures., (© 2025 The Authors.)
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- 2025
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36. Promoting women's careers in life science and medicine: A position paper from the "International Women in Intensive Medicine" network.
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Hamzaoui O, Boissier F, Teixera C, Mascia L, Aragao I, Bahrami S, Delgado MCM, Mellin-Oslen J, Rello J, and Rubulotta F
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Background: Women remain underrepresented and undervalued in leadership roles within scientific and healthcare disciplines, facing persistent gender discrimination and various professional barriers., Methods: This paper presents the main findings and recommendations from the 2023 International Women in Intensive and Critical Care Network (iWIN) Roundtable, which convened a diverse group of experts to discuss equity and inclusiveness for women in their careers., Results: The discussion highlighted three critical themes: social barriers (such as maternal identity and cultural pressures), the need for resilience-building through mentorship/sponsorship and support networks; and practical challenges, including childcare and limited career guidance. To address these issues, the panel proposed developing and empowering women's networks, emphasizing their role in promoting gender equality, fostering diversity, and supporting professional development. A key recommendation is the creation of a digital platform to increase the visibility of women scientists and connect them with opportunities for engagement and leadership. Additionally, the paper underscores the importance of institutional support for flexible work arrangements, mentorship programs, and leadership development initiatives., Conclusions: The proposed strategies aim to not only advance the careers of women in science and healthcare but also to challenge and reshape the stereotypes surrounding who can be a scientist. By providing practical tools and fostering a culture of inclusiveness, these recommendations have the potential to significantly impact the representation of women in these fields and contribute to broader societal change., Competing Interests: Declaration of competing interest The authors have no competing interests to declare in relation to the subject of the manuscript, (Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2025
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37. Effects of impulsivity and emotions on time perception: Laboratory behavioral measures.
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Moreira D, Azeredo A, Leite Â, and Barbosa F
- Abstract
Impulsivity is consistently linked to various problematic behaviors, including aggression, substance abuse, pathological gambling, risky driving, and numerous psychopathological disorders such as attention deficit hyperactivity disorder and personality disorders. This study aims to investigate the relationship between self-reported impulsivity, measured by the Behavioral Inhibition/Behavioral Activation Scales, and emotional states (pleasant, unpleasant, or neutral), in the context of time estimation deviations. A time estimation task was administered to 129 adult participants (88 females) from the community to assess this deviation. The findings reveal that participants underestimated time across all emotional conditions, enhancing our understanding of how impulsivity relates to time perception. Therefore, it is crucial to continue neuropsychophysiological research on impulsivity to explore its causes, manifestations, and connections with other aspects of cognitive and affective functioning. This research will lead to a more precise definition and comprehensive understanding of impulsive behavior., Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2025
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38. Refining risk assessment for intra-abdominal infections in immunocompromised intensive care unit patients. Author's reply.
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Blot S, Deschepper M, and Paiva JA
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- 2025
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39. Advancing Towards a Targeted Surveillance Strategy in Traumatic Brain Injury.
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Moura Gonçalves VT
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- 2025
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40. Synthetic peptides bioactive against phytopathogens have lower impact on some beneficial bacteria: An assessment of peptides biosafety in agriculture.
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Gimranov E, Santos J, Regalado L, Teixeira C, Gomes P, Santos C, and Pereira-Dias L
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- Antimicrobial Peptides pharmacology, Anti-Bacterial Agents pharmacology, Bacteria drug effects, Plant Diseases prevention & control, Plant Diseases microbiology, Biological Control Agents pharmacology, Peptides pharmacology, Microbial Sensitivity Tests, Agriculture methods
- Abstract
The emergence of bacterial resistance and the increasing restrictions on the use of agrochemicals are boosting the search for novel, sustainable antibiotics. Antimicrobial peptides (AMPs) arise as a new generation of antibiotics due to their effectiveness at low doses and biocompatibility. We compared the antimicrobial activity of four promising AMPs (CA-M, BP100, RW-BP100, and 3.1) against a collection of notorious phytopathogens, and quantified their impact on plant beneficial bacteria. Plant growth promoters (PGP) and biological control agents (BCA) were also included to study the feasibility of integrating AMPs with bio-based strategies to mitigate diseases impacts and promote crop production. Flow cytometry and fluorescence microscopy revealed that the AMPs' effects on the membrane integrity of both gram-negative and gram-positive strains were time- and concentration-dependent. Bacterial strains were separated into three groups of susceptibility to the AMPs. Group 1 was represented by the most sensitive, gram-negative phytopathogenic belonging to Xanthomonadales and Pseudomonadales and the gram-positive C. michiganensis subsp. michiganensis. Group 2 encompassed bacteria showing intermediate susceptibility, namely P. carotovorum subsp. carotovorum, P. cerasi, both phytopathogens, as well as the plant growth promoters P. fluorescens and P. putida. Finaly, Group 3 was represented by the bacteria with the lowest susceptibility to AMPs. It included beneficial bacteria (B. zhangzhouensis, B. subtilis, B. safensis, P. azotoformans), a phytopathogen (R. solanacearum), and a strain reported as able to act as both (P. aeruginosa). This work demonstrates that the minimum inhibitory concentrations (MICs) needed to act against the beneficial Bacillus and Pseudomonas strains were higher than those needed to produce bacteriostatic or bactericidal effects on the phytopathogens tested, hence supporting that these AMPs might be environmentally safe antibiotics with low likeliness of disrupting the beneficial microbial communities. The possibility of mixing these AMPs with BCA/PGP, in a combined biocontrol strategy, is also discussed., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 Elsevier Ltd. All rights reserved.)
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- 2025
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41. Direct and transgenerational effects of simvastatin on the metabolism of the amphipod Gammarus locusta.
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Rodrigues JA, Chaves RS, Santos MM, Neuparth T, and Gil AM
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- Animals, Female, Male, Metabolomics, Osmoregulation drug effects, Citric Acid Cycle drug effects, Energy Metabolism drug effects, Amphipoda drug effects, Water Pollutants, Chemical toxicity, Simvastatin toxicity
- Abstract
In this study, untargeted Nuclear Magnetic Resonance (NMR) metabolomics was applied for the first time, to our knowledge, to assess the metabolic impact of direct and transgenerational exposure (F0 and F3 generations, respectively) of amphipods Gammarus locusta to simvastatin (SIM), a pharmaceutical widely prescribed for the treatment of hypercholesterolemia. Results revealed the important gender-dependent nature of each of these effects. Directly exposed males showed enhanced glucose catabolism and tricarboxylic acid (TCA) cycle activity, in tandem with adaptations in osmotic regulation and glyoxylate metabolism. Exposed females exhibited only a small osmoregulatory effect. It is suggested that the response of exposed males may reflect reported high levels of methyl farnesoate hormone (low levels in females) and alterations in apical factors, namely decreased growth. Conversely, transgenerational effects were identified only in females, with impact on energy metabolism (glycolysis and TCA cycle enhancement) and osmoregulatory response. This expresses the ability of female gametes to transmit the effects of direct SIM exposure. Such effects were putatively related to reported delayed maturation and transcriptomic deviations impacting on carbohydrate and lipid metabolisms, possibly specifically engaging phenylalanine/tyrosine and choline in dopamine and choline metabolisms. These findings reflect the importance of untargeted metabolomics in addressing not only direct exposure of contaminants, but also their transgenerational effects, potentially contributing towards improving hazard and risk assessment of biologically active compounds., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)
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- 2025
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42. Evaluating feature importance biases in logistic regression: Recommendations for Robust Statistical Methods. Author's reply.
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Deschepper M, Paiva JA, and Blot S
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- 2025
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43. Intraspecific variation in the feeding habits of short-finned pilot whales based on blubber fatty acid profiles.
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Íñiguez E, Sambolino A, Escánez Pérez A, Marrero Pérez J, Reis DB, Pimentel A, Weyn M, Fernandez M, Cordeiro N, Pérez Pérez JA, Dinis A, Rodríguez González C, and Alves F
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- Animals, Female, Male, Adipose Tissue, Ecosystem, Diet veterinary, Whales, Pilot physiology, Fatty Acids analysis, Fatty Acids metabolism, Feeding Behavior
- Abstract
Understanding trophic interactions in deep-sea ecosystems is challenging and still largely unexplored. Here, fatty acid (FA) profiles were used as biochemical tracers to explore intraspecific feeding specialization in a deep-diving apex predator. The FA profiles of free-ranging short-finned pilot whale (Globicephala macrorhynchus) biopsies from two archipelagos (Canary Islands, n = 30; Madeira Island, n = 25) of the Macaronesia biogeographic region were determined to infer the dietary preferences, ecological adaptations, and population dynamics, considering geographic location, sex, and residency patterns (HIA: highly island-associated vs. "others": visitors or transients). Intraspecific variability (inferred through the representation of PERMANOVA analyses) was observed between HIA groups from the two archipelagos which exhibited distinct trophic niches. The "others" FA profiles largely overlapped with both groups, showing significant differences with HIA from the Canary Islands. This suggests that the "others" travel and forage across a broader area, likely encompassing these archipelagos. The differences between archipelagos were mainly attributed to a higher presence of the FA 20:1n-11 and 22:1n-11 in the animals from the Canary Islands, in contrast with a higher presence of 22:6n-3, 22:5n-3 and 20:5n-3 in the animals from Madeira. These findings suggest that short-finned pilot whales in Madeira may prefer a more pelagic diet, likely leveraging on nocturnal migrations of the Deep Scattering Layer and/or performing wider-ranging movements, while the animals in the Canary Islands may forage closer to the bottom and/or occupy a smaller core area. Overall, this study supports intraspecific feeding specialization by a deep-diving apex predator in two geographically related oceanic archipelagos., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2025
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44. Mortality, functional outcome and health-related quality of life in patients with necrotizing skin- and soft tissue infections in the ICU: Protocol of a multinational prospective cohort study (SKIN-ICU).
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Urbina T, Madsen MB, Hua C, Eckmann C, Elhadi M, Gurjar M, De Pascale G, Zand F, Hästbacka J, Rocca RF, Paiva JA, Mikstacki A, Layese R, Chosidow O, Canoui-Poitrine F, Waele J, and de Prost N
- Abstract
Background: Necrotizing soft tissue infections (NSTI) are rare and life-threatening bacterial infections characterized by necrosis of subcutaneous tissue, fascia, or muscle. Few prospective studies have been conducted. The primary objective is to assess the 90-day mortality rate and to identify prognostic factors in patients with NSTI in an international setting. Secondary objectives are i) to characterize the clinical and microbiological presentation and management; ii) to assess the risk of limb amputation and associated factors; and iii) to assess functional and health-related quality of life (HRQoL) outcomes and associated factors., Methods: We are conducting a multinational, prospective, non-interventional cohort study. We plan to enroll 1,033 consecutive patients admitted to 85 hospitals with surgically proven NSTI between November 2021 and December 2024 in 17 countries over three continents. Data will be collected prospectively on a secure web-based server. The primary outcome measure will be the day-90 mortality. Secondary outcomes include need for limb amputation, the activity of daily living scale and health-related quality of life at day-90 (EQ-5D-5L questionnaire). Baseline characteristics associated with outcomes will be identified by multivariable analyses. Exploratory analyses will be conducted to assess the impact of therapeutic interventions on day-90 mortality and secondary outcomes. The study protocol has been approved by an ethics committee in each participating country., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)
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- 2025
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45. Advances in Diagnosis, Treatment and Prognostic in Aortoiliac Occlusive Disease - A Narrative Review.
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Azevedo M, Nóbrega L, and Rocha-Neves J
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- Humans, Prognosis, Aorta, Abdominal diagnostic imaging, Iliac Artery, Arterial Occlusive Diseases diagnosis, Arterial Occlusive Diseases therapy, Aortic Diseases therapy, Aortic Diseases diagnosis
- Abstract
Background: Aortoiliac disease (AID) is a variant of peripheral artery disease involving the infrarenal aorta and iliac arteries. Similar to other arterial diseases, aortoiliac disease obstructs blood flow through narrowed lumens or by embolization of plaques. AID, when symptomatic, may present with a triad of claudication, impotence, and absence of femoral pulses, a triad also referred as Leriche Syndrome (LS)., Objective: The authors aim to review the available evidence on the management of the aortoiliac occlusive disease and describe its clinical characteristics, diagnosis and treatment management., Methods: A comprehensive review of the literature was carried out to collect data from relevant studies concerning patients with moderate to severe symptomatic aortic occlusive disease. The data was identified by a search using PubMed and Google Scholar with the keywords / MESH terms "aortoiliac occlusive disease". For this study, the authors included papers published in the past two decades, written in English., Results: The diagnosis and evaluation of extensive aortoiliac disease involves several important considerations: vascular imaging plays a fundamental role in confirming the diagnosis of peripheral artery disease (PAD), evaluating the severity and extent of the disease and directing the planning of revascularization procedures. It provides essential information to select the most appropriate treatment modality., Conclusion: Despite successful revascularization, patients are at high risk of mortality and numerous life-threatening complications. Clinical and imagiologic factors may be used for risk stratification in order to select appropriate patients for revascularization and to better counsel patients about expected postoperative outcomes.
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- 2025
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46. Drug use Risks in Portuguese Rural vs Urban Environments: Harm Reduction Challenges in a Progressive Drug Policy Setting.
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de Sousa Pinto MS, Pires CV, de Carvalho HMRM, Pereira CP, da Silva GAP, de Jesus Grilo Carapinha L, Gonçalves FO, and Valente H
- Abstract
Portugal is commonly recognized as one of the best drug policy examples in the world. Nonetheless, contrasts between drug use risks in rural vs urban settings in the country is an understudied topic, even if its specific challenges are commonly affirmed, both by professionals and people who use drugs (PWUD). The aim of this study was to compare rural and urban environments concerning socio-sanitary services availability; illegal drugs availability; risk behaviors related to drug use; stigma associated with illicit drug use; and social support. Additionally, specific harm reduction challenges and recommendations for improvement were explored. A qualitative study with two focus groups involving people who use drugs, outreach workers and local decision-makers was conducted. Distinct scenarios and challenges in both settings were found: In large cities, a significantly higher specialized service coverage than in rural areas was described. In rural settings, a higher number of drug-related risks, higher levels of stigma and lower availability of human and material resources were mentioned, although being associated with higher levels of informal social support and more proximal relationships with harm reduction teams. This study emphasizes the need for a harm reduction paradigm strongly focused on environmental risk determinants, as much as in individual ones.
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- 2025
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47. Effect of dehydration of Syrah grape berries on the aging potential of fortified sweet wines in Ningxia of China.
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Zhang X, Wang K, Wang Q, Shi Z, Oliveira H, Mateus N, and Han F
- Abstract
Many of wines from western China suffer from the short lifespan of aging. This study was conducted to investigate the effects of grape dehydration on aging potential of fortified sweet wines. Compared with the control wine (CK), dehydration significantly raised the sugar, organic acids and acetic esters content of G20 and G40 wines (made by 20 % and 40 % weight loss grapes). Dehydration also enhanced the stability of anthocyanins and the color of wines. After 24 months of aging, G20 had the highest monomeric anthocyanin content, and the variations of a
⁎ , b values were lowest in G40. Furthermore, dehydrated samples presented better aging stability with the improved sensory characteristics such as stronger black fruit fragrance, fuller body and richer aftertaste. In general, Syrah fortified sweet wine provides a new option for high quality wines with stable color, concentrated aroma, rich taste, and high aging potential in Ningxia of China.⁎ and H⁎ ab values were lowest in G40. Furthermore, dehydrated samples presented better aging stability with the improved sensory characteristics such as stronger black fruit fragrance, fuller body and richer aftertaste. In general, Syrah fortified sweet wine provides a new option for high quality wines with stable color, concentrated aroma, rich taste, and high aging potential in Ningxia of China., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2025 The Authors. Published by Elsevier Ltd.)- Published
- 2025
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48. Patients' emotional expressions and clinicians' responses in oncology - From recognition to exploration of concerns.
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Romeiro FB, Pais VG, Humphris G, and Figueiredo-Braga M
- Abstract
Objectives: The objective of this study was to analyze patient's emotional expressions during the consultations and the responses of their oncologists to these expressions., Methods: The study employed a mixed-method, observational, descriptive, and explanatory design. A total of 31 adult patients at different clinical stages, undergoing cancer treatment and 8 oncologists were included. Thirty-one routine outpatient oncology consultations were analyzed, after being transcribed and coded, using the Portuguese version of the Verona Coding Definitions of Emotional Sequences (VR-CoDES)., Results: The oncologists elicited and recognized patients' emotional concerns but they did not explore them in a way that encouraged patients to continue verbalizing their feelings. Oncologists provided more directive and guidance-oriented responses, focusing on cues related to physical pain and symptoms. Multilevel logistic regression analysis modeled the probability of oncologists' responses showing reduction of space in relation to patients' emotional cues/concerns, controlling for clustering and patients' clinical and socio-demographic variables. The type of cue and treatment influenced the oncologists' responses., Conclusions: Communication skills training focused on the ability to better explore patients' emotions may help oncologists to provide more explicit and empathetic responses that validate the emotional content expressed during consultations. Practice Implications: Oncologists do not use the same responses as a standard with patients, thus adjusting them individually., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Unlabelled TableFernanda Bittencourt Romeiro reports financial support was provided by Coordination for the Improvement of Higher Education Personnel – Brazil (CAPES) – Financing Code 001. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2025 The Authors. Published by Elsevier B.V.)
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- 2025
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49. Emotion regulation as a transdiagnostic construct across the spectrum of disordered eating in adolescents: A systematic review.
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Félix S, Gonçalves S, Ramos R, Tavares A, Vaz AR, Machado PPP, and Conceição E
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- Humans, Adolescent, Female, Feeding Behavior psychology, Anorexia Nervosa psychology, Adolescent Behavior psychology, Feeding and Eating Disorders psychology, Emotional Regulation physiology
- Abstract
Objective: This systematic review aimed to understand the role of emotion regulation (ER) across the spectrum of disordered eating behaviors and attitudes in adolescents., Method: A literature search was conducted using the PubMed, Scopus, and Web of Science databases, and 8381 articles were extracted. After removing duplicates and screening, data from 50 articles involving 31,591 participants from 18 countries were included., Results: Consistent associations between difficulties in ER/maladaptive ER and overeating (but not restrictive) behaviors/attitudes were found among adolescents without an eating disorder diagnosis. In contrast, in adolescents with eating disorders, ER difficulties were associated with restrictive-, compensatory- and overeating-type eating disorders. More difficulties in ER were found among adolescents with eating disorder diagnoses (i.e., anorexia nervosa, bulimia nervosa, or binge eating disorder) than among their healthy/normal-weight peers. Nonetheless, difficulties in ER abilities and in the implementation of ER strategies were greater in adolescents with anorexia nervosa or bulimia nervosa than in adolescents with binge eating disorder. Finally, concerning the role of adaptive ER, although fewer adaptive ER strategies were consistently found in adolescents with a diagnosis of anorexia nervosa than in healthy controls, the results in community samples were less consistent., Discussion: Overall, ER was associated with disordered eating behaviors/attitudes and eating disorder diagnoses, supporting the transdiagnostic role of ER in the spectrum of eating psychopathology. Fewer consistent findings were found across the weight spectrum, specifically at the higher end (overweight/obesity). These results highlighted the role of different ER abilities and strategies and the relevance of maladaptive (vs. adaptive) ER in understanding disordered eating. The findings also set the context for developing specific ER-based interventions across the spectrum of disordered eating behaviors and attitudes., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2025
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50. Forensic analysis of an alleged improvised explosive device (IED) from a multidisciplinary perspective: Organisation and outcomes of the ENFSI 2023 exercise.
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Zampa F, Bandey H, Beardah M, Bécue A, Bouzaid E, Branco MJ, Buegler J, Kambosos M, Kneppers ALJ, Kriiska-Maiväli K, Mattei A, and Zatkalikova L
- Subjects
- Humans, Hair chemistry, Dermatoglyphics, Forensic Sciences methods, Explosive Agents, DNA Fingerprinting
- Abstract
Interdisciplinary examination of test materials requires careful consideration of how forensic routines can influence each other. This influence can be direct and obvious, or indirect and subtle. A multidisciplinary collaborative exercise (MdCE) should test a forensic laboratory's ability to account for these difficulties. Therefore, the MdCE should be set up in a way that considers how the applied procedure (i.e., the sequence of forensic disciplines) can impact the outcomes (i.e., the ability to recover traces). Building on lessons learned from a previous experience, this article summarises the concepts, planning, design, preparation, implementation, coordination and evaluation of the ENFSI 2023 Multidisciplinary Collaborative Exercise (2023-MdCE) covering a range of forensic disciplines, specifically DNA, fingerprints, explosives, fibres, and hair morphological analysis. The exercise consisted of a glass jar with black adhesive tape around it, representing an improvised explosive device. The analysis of the results highlighted: a) the importance of a joint preliminary optical examination; b) some critical issues regarding the explosives/fingerprint sampling strategies; c) the potential impact of contact marks that may contain friction ridge detail on items that were different from those deposited by the organiser; d) the importance of avoiding discrepancies in labelling exhibits and/or traces is emphasised as it is related to the communication strategy of scientific forensic results. Additionally, recommendations and suggestions are provided for those who may wish to undertake such a collaborative exercise., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Chartered Society of Forensic Sciences. All rights reserved.)
- Published
- 2025
- Full Text
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