Author: "University of Hertfordshire [Hatfield] (UH)" - Searchworks@Jio Institute Digital Library Search Results

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201 results on '"University of Hertfordshire [Hatfield] (UH)"'

1. Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collaboration with the ESC Council on Valvular Heart Disease

Author: Diana A. Gorog, Erik Lerkevang Grove, Dariusz Dudek, Andrea Rubboli, Julinda Mehilli, Jurriën M. ten Berg, Gemma Vilahur, Julia Grapsa, Lucia Torracca, Bianca Rocca, Adam Witkowski, Anna Sonia Petronio, Eric Van Belle, Patrizio Lancellotti, Jean-Philippe Collet, Dirk Sibbing, Martine Gilard, Bernard Chevalier, Cardiologie, RS: Carim - B04 Clinical thrombosis and Haemostasis, St. Antonius Hospital [Nieuwegein], Ludwig-Maximilians-Universität München [LMU], German Center for Cardiovascular Research [DZHK], Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] [Unicatt], Institut Coeur Poumon [CHU Lille], Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires [RNMCD - U1011], Hôpital Privé Jacques Cartier [Massy], CHU Pitié-Salpêtrière [AP-HP], Groupe Action, Hôpital de la Cavale Blanche, Université de Brest [UBO], Imperial College London, University of Hertfordshire [Hatfield] [UH], Aarhus University Hospital, Centre Hospitalier Universitaire de Liège [CHU-Liège], University of Pisa - Università di Pisa, Hospital de la Santa Creu i Sant Pau, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University [Maastricht], Ludwig-Maximilians-Universität München (LMU), German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), CHU Lille, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 (RNMCD), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Jagiellonian University - Medical College (JUMC), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Maria Cecilia Hospital [Cotignola], Université de Brest (UBO), University of Hertfordshire [Hatfield] (UH), Guy's and St Thomas' NHS Foundation Trust [London, UK], Centre Hospitalier Universitaire de Liège (CHU-Liège), and National Institute of Cardiology [Varsovie, Pologne]
Subjects: medicine.medical_specialty, Percutaneous, Consensus, Settore BIO/14 - FARMACOLOGIA, [SDV]Life Sciences [q-bio], Heart Valve Diseases, 030204 cardiovascular system & hematology, Lower risk, law.invention, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Antithrombotic treatment, Transcatheter aortic valve implantation, Aged, Aortic Valve, Fibrinolytic Agents, Humans, Treatment Outcome, Aortic Valve Stenosis, Heart Valve Prosthesis Implantation, Thrombosis, Randomized controlled trial, law, Internal medicine, Antithrombotic, medicine, 030212 general & internal medicine, Adverse effect, Aortic Valve/surgery, ANTIPLATELET THERAPY, business.industry, Fibrinolytic Agents/therapeutic use, valvular heart disease, Thrombosis/drug therapy, medicine.disease, Stenosis, Aortic Valve Stenosis/drug therapy, Transcatheter Aortic Valve Replacement/adverse effects, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: Transcatheter aortic valve implantation (TAVI) is effective in older patients with symptomatic severe aortic stenosis, while the indication has recently broadened to younger patients at lower risk. Although thromboembolic and bleeding complications after TAVI have decreased over time, such adverse events are still common. The recommendations of the latest 2017 ESC/EACTS Guidelines for the management of valvular heart disease on antithrombotic therapy in patients undergoing TAVI are mostly based on expert opinion. Based on recent studies and randomized controlled trials, this viewpoint document provides updated therapeutic insights in antithrombotic treatment during and after TAVI.
Published: 2021

2. Music and Metronomes Differentially Impact Motor Timing in People with and without Parkinson’s Disease: Effects of Slow, Medium, and Fast Tempi on Entrainment and Synchronization Performances in Finger Tapping, Toe Tapping, and Stepping on the Spot Tasks

Author: Yvonne Delevoye-Turrell, Dawn Rose, Laurent Ott, L. E. Annett, Peter Lovatt, Université de Lille, CNRS, CHU Lille, University of Hertfordshire [Hatfield] [UH], Lucerne University of Applied Sciences and Arts [Luzern], Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193, University of Hertfordshire [Hatfield] (UH), Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), and Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: medicine.medical_specialty, Parkinson's disease, Article Subject, business.industry, Beats per minute, Neuroscience (miscellaneous), Metronome, medicine.disease, lcsh:RC346-429, law.invention, [SCCO]Cognitive science, Psychiatry and Mental health, Physical medicine and rehabilitation, Rhythm, Embodied cognition, law, Finger tapping, medicine, Tapping, Neurology (clinical), Entrainment (chronobiology), business, lcsh:Neurology. Diseases of the nervous system, Research Article
Abstract: Introduction. Rhythmic auditory stimulation (RAS) has successfully helped regulate gait for people with Parkinson’s disease. However, the way in which different auditory cues and types of movements affect entrainment, synchronization, and pacing stability has not been directly compared in different aged people with and without Parkinson’s. Therefore, this study compared music and metronomes (cue types) in finger tapping, toe tapping, and stepping on the spot tasks to explore the potential of RAS training for general use. Methods. Participants (aged 18–78 years) included people with Parkinson’s (n = 30, Hoehn and Yahr mean = 1.78), older (n = 26), and younger adult controls (n = 36), as age may effect motor timing. Timed motor production was assessed using an extended synchronization-continuation task in cue type and movement conditions for slow, medium, and fast tempi (81, 116, and 140 mean beats per minute, respectively). Results. Analyses revealed main effects of cue and movement type but no between-group interactions, suggesting no differences in motor timing between people with Parkinson’s and controls. Music supported entrainment better than metronomes in medium and fast tempi, and stepping on the spot enabled better entrainment and less asynchrony, as well as more stable pacing compared to tapping in medium and fast tempi. Age was not confirmed as a factor, and no differences were observed in slow tempo. Conclusion. This is the first study to directly compare how different external auditory cues and movement types affect motor timing. The music and the stepping enabled participants to maintain entrainment once the external pacing cue ceased, suggesting endogenous mechanisms continued to regulate the movements. The superior performance of stepping on the spot suggests embodied entrainment can occur during continuous movement, and this may be related to emergent timing in tempi above 600 ms. These findings can be applied therapeutically to manage and improve adaptive behaviours for people with Parkinson’s.
Published: 2019

3. A general procedure to measure the pacing of body movements timed to music and metronome in younger and older adults

Author: Dawn Rose, Laurent Ott, Ségolène M. R. Guérin, Lucy E. Annett, Peter Lovatt, Yvonne N. Delevoye-Turrell, Université de Lille, CNRS, CHU Lille, University of Hertfordshire [Hatfield] [UH], Lucerne University of Applied Sciences and Arts [Luzern], 415060|||Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 [SCALab], 374570|||Université de Lille, University of Hertfordshire [Hatfield] (UH), Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193 (SCALab)
Subjects: Science, [SCCO.PSYC]Cognitive science/Psychology, Medicine
Abstract: International audience; Abstract Finger-tapping tasks are classically used to investigate sensorimotor synchronization in relation to neutral auditory cues, such as metronomes. However, music is more commonly associated with an entrained bodily response, such as toe tapping, or dancing. Here we report an experimental procedure that was designed to bridge the gap between timing and intervention studies by directly comparing the effects of metronome and musical cue types on motor timing abilities across the three naturalistic voluntary actions of finger tapping, toe tapping, and stepping on the spot as a simplified case of whole body movement. Both pacing cues were presented at slow, medium, and fast tempi. The findings suggested that the task of stepping on the spot enabled better timing performances than tapping both in younger and older adults (75+). Timing performances followed an inverse U shape with best performances observed in the medium tempi that were set close to the spontaneous motor tempo in each movement type. Finally, music provided an entrainment effect in addition to pace setting that enabled better motor timing and greater stability than classically reported using a metronome. By applying time-stamp analyses to kinetic data, we demonstrate that tapping and stepping engage different timing modes. This work details the importance of translational research for a better understanding of motor timing. It offers a simple procedure that strengthens the validity of applying academic work and contributes in knowledge towards a wide range of therapeutic interventions.
Published: 2021

4. The BASES expert statement on the use of music for movement among people with Parkinson’s

Author: Karageorghis, Costas, Rose, Dawn, Annett, Lucy, Bek, Judith, Bottoms, Lindsay, Lovatt, Peter, Poliakof, Ellen, Schultz, Benjamin, Whyatt, Caroline, Young, William, Delevoye, Yvonne, Université de Lille, CNRS, CHU Lille, Brunel University London [Uxbridge], Lucerne University of Applied Sciences and Arts [Luzern], University of Hertfordshire [Hatfield] [UH], University of Manchester [Manchester], University of Melbourne, University of Exeter, Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193, University of Hertfordshire [Hatfield] (UH), Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), and Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SCCO]Cognitive science, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020

5. The 67P/Churyumov-Gerasimenko observation campaign in support of the Rosetta mission

Author: Benoit Carry, M. F. A'Hearn, Sebastien Besse, Michaël Gillon, M. J. Mumma, Galin Borisov, B. Rajkumar, Janet E. Drew, Olga Muñoz, Viktor Afanasiev, Tarik Zegmott, Lucas Paganini, D. Bodewits, Rita Schulz, Emily Kramer, Adam J. McKay, Diane H. Wooden, J. de León, Michael Schmidt, Geraint H. Jones, S. Haque, Andrew McNeill, Fernando Moreno, Sara Faggi, P. J. Gutiérrez, Jérémie Lasue, Aurélie Guilbert-Lepoutre, J. M. Sunshine, Javier Licandro, Zhong-Yi Lin, Pedro Lacerda, Philippe Rousselot, Jose Luis Ortiz, Nicolas Biver, Marco Micheli, J. J. López-Moreno, Matthew M. Knight, Jon Marchant, Detlef Koschny, Dominik R. G. Schleicher, F. Aceituno, Michael S. P. Kelley, Colin Snodgrass, G. P. Tozzi, Michael A. DiSanti, Karen J. Meech, Olivier Hainaut, Alfredo Sota, Niklas J. T. Edberg, Edith Hadamcik, Rene Duffard, Rosita Kokotanekova, Erika L. Gibb, Damien Hutsemekers, E. Ramos, Y. Ramanjooloo, A. Guijarro, Ulrich Hopp, Luisa Lara, Stephen C. Lowry, Tim Lister, Anita L. Cochran, V. Casanova, Pablo Santos-Sanz, J. Kleyna, R. Hedrosa, M. Pajuelo, A. K. Sen, Cyrielle Opitom, Emmanuel Jehin, A. Thompson, Alan Fitzsimmons, Geronimo L. Villanueva, E. J. W. de Mooij, Stefano Bagnulo, C. Ries, Boncho P. Bonev, O. Ivanova, Amy Mainzer, John K. Davies, Blair C. Conn, Anny Chantal Levasseur-Regourd, P. Nikolov, Auni Somero, Nikolai Kiselev, Lori M. Feaga, Maria Monguió, Francisco J. Pozuelos, A. Stinson, M. Delacruz, Björn Davidsson, Jacqueline V. Keane, M. Kluge, Dean C. Hines, Simon F. Green, Jean Manfroid, James Bauer, Silvia Protopapa, M. de Val-Borro, T. Pursimo, Xiaobin Wang, Cecilia Tubiana, Hermann Boehnhardt, Masafumi Yagi, I. Mohammed, Vera Rosenbush, F. Hoyo, Harry Lehto, G. Bergond, B. Yang, Méabh Hyland, Arno Riffeser, Hideaki Fujiwara, Erin L. Ryan, B. Zaprudin, School of Physical Sciences [Milton Keynes], The Open University [Milton Keynes] ( OU ), Department of Astronomy [College Park], University of Maryland [College Park], Instituto de Astrofísica de Andalucía ( IAA ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Special Astrophysical Observatory of the Russian Academy of Sciences ( SAO ), Russian Academy of Sciences [Moscow] ( RAS ), Armagh Observatory [Armagh], Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), Centro Astronómico Hispano Alemán, European Space Astronomy Center ( ESAC ), European Space Agency ( ESA ), Laboratoire d'études spatiales et d'instrumentation en astrophysique ( LESIA ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Max-Planck-Institut für Sonnensystemforschung ( MPS ), Department of Physics [Washington], American University Washington D.C. ( AU ), Institute of Astronomy and National Astronomical Observatory, Bulgarian Academy of Sciences, Joseph Louis LAGRANGE ( LAGRANGE ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Mécanique Céleste et de Calcul des Ephémérides ( IMCCE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université de Lille-Centre National de la Recherche Scientifique ( CNRS ), McDonald Observatory, University of Texas at Austin [Austin], Research School of Astronomy and Astrophysics [Canberra] ( RSAA ), Australian National University ( ANU ), Gemini Observatory [Southern Operations Center], Association of Universities for Research in Astronomy ( AURA ), UK Astronomy Technology Centre ( UK ATC ), Science and Technology Facilities Council ( STFC ), Universidad de La Laguna ( ULL ), Instituto de Astrofisica de Canarias ( IAC ), Astrophysics Research Centre [Belfast] ( ARC ), Queen's University [Belfast] ( QUB ), Catholic University of America, Astrochemistry Laboratory [Greenbelt], NASA Goddard Space Flight Center ( GSFC ), Department of Astrophysical Sciences [Princeton], Princeton University, Institute for Astronomy [Honolulu], University of Hawaii at Manoa ( UHM ), School of Physics, Astronomy and Mathematics [Hatfield], University of Hertfordshire [Hatfield] ( UH ), Swedish Institute of Space Physics [Uppsala] ( IRF ), National Astronomical Observatory of Japan ( NAOJ ), Department of Physics and Astronomy [Columbia], University of Missouri-Columbia, Institut d'Astrophysique et de Géophysique [Liège], Université de Liège, Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules ( UTINAM ), Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), IMPEC - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales ( LATMOS ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), European Southern Observatory ( ESO ), Department of Physics [Trinidad], The University of the West Indies, Space Telescope Science Institute ( STSci ), Ludwig-Maximilians University [Munich] ( LMU ), Astronomical Institute of the Slovak Academy of Sciences, Slovak Academy of Science [Bratislava] ( SAS ), Mullard Space Science Laboratory ( MSSL ), University College of London [London] ( UCL ), Centre for Planetary Sciences [UCL/Birkbeck] ( CPS ), Main Astronomical Observatory of NAS of Ukraine ( MAO ), National Academy of Sciences of Ukraine ( NASU ), Research and Scientific Support Department, ESTEC ( RSSD ), European Space Research and Technology Centre ( ESTEC ), European Space Agency ( ESA ) -European Space Agency ( ESA ), Institut de recherche en astrophysique et planétologie ( IRAP ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Tuorla Observatory, University of Turku, Institute of Astronomy [Taiwan] ( IANCU ), National Central University [Taiwan] ( NCU ), Las Cumbres Observatory ( LCO ), Centre for Astrophysics and Planetary Science [Canterbury] ( CAPS ), University of Kent [Canterbury], Astrophysics Research Institute [Liverpool] ( ARI ), Liverpool John Moores University ( LJMU ), ESA SSA-NEO Coordination Centre, Caribbean Institute of Astronomy ( CARINA ), Pontificia Universidad Católica del Perú ( PUCP ), Nordic Optical Telescope ( NOT ), SETI Institute, Lowell Observatory [Flagstaff], European Space Agency, Scientific Support Office, Assam University, INAF - Osservatorio Astrofisico di Arcetri ( OAA ), Istituto Nazionale di Astrofisica ( INAF ), Key Laboratory for the Structure and Evolution of Celestial Objects, Chinese Academy of Sciences [Beijing] ( CAS ), Yunnan Observatories, Chinese Academy of Sciences [Changchun Branch] ( CAS ), NASA Ames Research Center ( ARC ), Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), University of Maryland System-University of Maryland System, Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Special Astrophysical Observatory of the Russian Academy of Sciences (SAO), Russian Academy of Sciences [Moscow] (RAS), Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Centro Astronómico Hispano Alemán, Observatorio de Calar Alto (CAHA), European Space Astronomy Centre (ESAC), European Space Agency (ESA), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, American University Washington D.C. (AU), Institute of Astronomy of the Bulgarian Academy of Sciences, Bulgarian Academy of Sciences (BAS), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Research School of Astronomy and Astrophysics [Canberra] (RSAA), Australian National University (ANU), Association of Universities for Research in Astronomy (AURA), UK Astronomy Technology Centre (UK ATC), Science and Technology Facilities Council (STFC), Universidad de La Laguna [Tenerife - SP] (ULL), Instituto de Astrofisica de Canarias (IAC), Astrophysics Research Centre [Belfast] (ARC), Queen's University [Belfast] (QUB), NASA Goddard Space Flight Center (GSFC), University of Hawai‘i [Mānoa] (UHM), University of Hertfordshire [Hatfield] (UH), Swedish Institute of Space Physics [Uppsala] (IRF), National Astronomical Observatory of Japan (NAOJ), Department of Physics and Astronomy [Columbia] (Mizzou Physics), University of Missouri [Columbia] (Mizzou), University of Missouri System-University of Missouri System, Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), European Southern Observatory (ESO), Space Telescope Science Institute (STSci), Ludwig-Maximilians-Universität München (LMU), Slovak Academy of Science [Bratislava] (SAS), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), Centre for Planetary Sciences [UCL/Birkbeck] (CPS), Main Astronomical Observatory of NAS of Ukraine (MAO), National Academy of Sciences of Ukraine (NASU), Research and Scientific Support Department, ESTEC (RSSD), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA)-European Space Agency (ESA), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), Las Cumbres Observatory (LCO), Centre for Astrophysics and Planetary Science [Canterbury] (CAPS), Astrophysics Research Institute [Liverpool] (ARI), Liverpool John Moores University (LJMU), Caribbean Institute of Astronomy (CARINA), Pontificia Universidad Católica del Perú (PUCP), Nordic Optical Telescope (NOT), ESA Scientific Support Office, INAF - Osservatorio Astrofisico di Arcetri (OAA), Istituto Nazionale di Astrofisica (INAF), Chinese Academy of Sciences [Beijing] (CAS), Chinese Academy of Sciences [Changchun Branch] (CAS), NASA Ames Research Center (ARC), NASA-California Institute of Technology (CALTECH), Agence Spatiale Européenne = European Space Agency (ESA), Pôle Planétologie du LESIA, Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Agence Spatiale Européenne = European Space Agency (ESA)-Agence Spatiale Européenne = European Space Agency (ESA), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), and Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru (PUCP)
Subjects: Future studies, History, 010504 meteorology & atmospheric sciences, General Mathematics, Comet, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], General Physics and Astronomy, FOS: Physical sciences, Context (language use), 01 natural sciences, Astrobiology, Jupiter, 0103 physical sciences, 010303 astronomy & astrophysics, QC, 0105 earth and related environmental sciences, QB, Earth and Planetary Astrophysics (astro-ph.EP), comet 67P/Churyumov?Gerasimenko, Rosetta, solar system, observational astronomy, ta115, Spacecraft, business.industry, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], General Engineering, Articles, [ SDU.ASTR.EP ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Early results, business, [ SDU.ASTR.SR ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Astrophysics - Earth and Planetary Astrophysics
Abstract: We present a summary of the campaign of remote observations that supported the European Space Agency's Rosetta mission. Telescopes across the globe (and in space) followed comet 67P/Churyumov-Gerasimenko from before Rosetta's arrival until nearly the end of mission in September 2016. These provided essential data for mission planning, large-scale context information for the coma and tails beyond the spacecraft, and a way to directly compare 67P with other comets. The observations revealed 67P to be a relatively `well behaved' comet, typical of Jupiter family comets and with activity patterns that repeat from orbit-to-orbit. Comparison between this large collection of telescopic observations and the in situ results from Rosetta will allow us to better understand comet coma chemistry and structure. This work is just beginning as the mission ends -- in this paper we present a summary of the ground-based observations and early results, and point to many questions that will be addressed in future studies., Comment: Author prepared version; final published version available at journal. 22 pages
Published: 2017

6. The EChO science case

Author: Tinetti, G., Drossart, P., Eccleston, P., Hartogh, P., Isaak, K., Linder, M., Lovis, C., Micela, G., Olliver, M., Puig, L., Ribas, I., De Sio, A., Frith, J., Justtanot, K., Showman, A., Alard, C., Yurchenko, S. N., Parviainen, H., Fouqué, P., Oliva, E., Bordé, P., Balado, A., Varley, R., Di Giorgio, A., Griffin, M., Maillard, J. P., Maggio, A., Lellouch, E., Strazzulla, G., Villaver, E., Griffith, C., Stamper, R., Amado, P. J., Rezac, L., Laken, B., Hargrave, P., Orton, G., Thompson, S., Morales, J. C., Wright, G., Massi, F., Lundgaard Rasmussen, I., Altieri, F., Covino, E., Coustenis, A., Moses, J., Lithgow Bertelloni, C., Demangeon, O., Fletcher, L., Morales Calderón, M., Lo Cicero, U., López Puertas, M., Capria, M. T., Danielski, C., Luntzer, A., Bulgarelli, A., González Hernández, J., Jacquemoud, S., MacTavish, C., Mall, U., Christian Jessen, N., Sanromá, E., Femenía Castella, B., Rocchetto, M., Miles Paez, P., Allard, F., Aylward, A., Leconte, J., Palla, F., White, G., Malaguti, G., Cavarroc, C., Lammer, H., Leto, G., Batista, V., Adybekian, V., Readorn, K., Polichtchouk, I., Petrov, R., García Piquer, A., Pancrazzi, M., Gómez Leal, I., Israelian, G., Rebolo López, R., Peralta, J., Giro, E., Tecsa, M., Haigh, J., Moro Martín, A., Pezzuto, S., Piskunov, N., Agnor, C., Hollis, M., Radioti, A., De Kok, R., Gear, W., Eymet, V., Achilleos, N., Koskinen, T., Maurin, A. S., Rank Lüftinger, T., Barlow, M., Figueira, P., Affer, L., Viti, S., Machado, P., Vakili, F., Burston, R., González Merino, B., Dominic, C., Dorfi, E., Smith, A., Sitek, P., Sánchez Lavega, A., Kerschbaum, F., Hoogeeven, R., Ballerini, P., Filacchione, G., Rodler, F., Stixrude, L., Parmentier, V., Del Val Borro, M., Vandenbussche, B., Tingley, B. W., Deeg, H. J., Tabernero, H. M., Shore, S., Fossey, S., Alonso Floriano, F. J., Santos, N., Tozzi, A., Kipping, D., Maruquette, J. B., Trifoglio, M., Scandaratio, G., Scuderi, S., Hébrard, E., Lodieu, N., Forget, F., Gustin, J., Poretti, E., Murgas Alcaino, F., Sicardy, B., Stiepen, A., Hubert, B., Grodent, D., Magnes, W., Tennyson, J., Temple, J., Galand, M., Barton, E. J., Winter, B., Valdivieso, M. L., Cordier, D., Heredero, R. L., Barrado, D., Mueller Wodarg, I., Giani, E., Correira, A., Widemann, T., Ward Thompson, D., Montañés Rodríguez, P., Moya Bedon, A., Venot, O., Prinja, R., Pinfield, D., Waldmann, I., Morello, G., Lim, T., Pallé, E., Waters, R., Wawer, P., Lognonné, P., Pietrzak, R., Fernández Hernández, Maite, Winek, W., Andersen, A., Monteiro, M., Liu, S. J., Rengel, M., Tanga, P., Yelle, R., Barstow, J. K., Maldonado, J., Irshad, R., Nelson, R., Colomé, J., De Witt, J., Lanza, N., Glasse, A., Coudé du Foresto, V., Branduardi Raymont, G., Beaulieu, J. P., Claudi, R., García López, Ramón, Eales, S., López Valverde, M. A., Turrini, D., Vinatier, S., Crook, J., Damasso, M., Ramos Zapata, G., Kovács, G., Banaszkiewicz, M., Focardi, M., Mauskopf, P., Guedel, M., Rebordao, J., Stolarski, M., Adriani, A., Norgaard Nielsen, H. U., Selig, A., Peña Ramírez, K. Y., Schmider, F. X., Baffa, C., Piccioni, G., Pantin, E., Bowles, N., Hornstrup, A., Pilat Lohinger, E., Buchhave, L. A., Soret, L., Börne, P., López Morales, M., Medvedev, A., Gesa, L., Jones, H., Pérez Hoyos, S., Gerard, J. C., Bellucci, G., Morais, H., Álvarez Iglesias, C. A., Abe, L., Pinsard, F., Tessenyi, M., Blecka, M., Wawrzaszk, A., Middleton, K., Martín Torres, J., Cho, J., Berry, D., Rataj, M., Schrader, J. R., Scholz, A., Watkins, C., Abreu, M., Testi, L., Decin, L., Sánz Forcada, J., Sozzetti, A., Lagage, P. O., Ade, P., Alcala, J., Sousa, S., Espinoza Contreras, M., Swinyard, B., Dobrijévic, M., Sánchez Béjar, V. J., Krupp, N., Bakos, G., Chamberlain, S., Chadney, J., Brown, L., Iro, N., Montalto, M., Sethenadh, J., Bouy, H., Ottensamer, R., Kehoe, T., Doel, P., Delgado Mena, E., Read, P., Coates, A., Cecchi Pestellini, C., Guillot, T., Budaj, J., Selsis, F., Jarchow, C., Del Vecchio, C., Cassan, A., Burleigh, M. R., Pagano, I., Ray, T., Gambicorti, L., Biondi, D., Cerulli, R., Ciaravella, A., Watson, D., Deroo, P., Collura, A., Graczyk, R., North, C., Ramos, A. A., Waltham, D., Montes, D., Gianotti, F., Thrastarson, H., Cockell, C., Pace, E., Bryson, I., Gómez, H., Esposito, M., Azzollini, R., Allende Prieto, C., Gillon, M., Fabrizio, N., Rickman, H., Rees, J. M., Pascale, E., Luzzi, D., Bonford, B., Cole, R., Gizon, L., Licandro Goldaracena, J., Agundez, M., Lahav, O., Zapatero Osorio, M. R., Gaulme, P., Encrenaz, T., Heyrovsky, D., Guàrdia, J., Prisinzano, L., Terenzi, L., Swain, M., Grassi, D., Eiroa, C., Maxted, P., Kerins, E., Yung, Y., Irwin, P., Herrero, E., Guio, P., Boisse, I., Claret, A., Kervella, P., Heiter, U., Bézard, B., Cabral, A., Michaut, C., Giuranna, M., Hersant, F., Hueso, R., Savini, G., Snellen, I. A., Charnoz, S., Jones, G., Belmonte Avilés, J. A., Barber, R. J., Wisniowski, T., Morgante, G., University College of London [London] (UCL), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), INAF - Osservatorio Astronomico di Palermo (OAPa), Istituto Nazionale di Astrofisica (INAF), Laboratoire des technologies de la microélectronique (LTM), Université Joseph Fourier - Grenoble 1 (UJF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Dpto. de Organización de Empresas, Escuela Técnica Superior de Ingeniería Industrial de Barcelona, Universitat Politècnica de Catalunya [Barcelona] (UPC), Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Physics and Astronomy [Leicester], University of Leicester, U.S. Army Research Laboratory [Adelphi, MD] (ARL), United States Army (U.S. Army), Royal Observatory Edinburgh (ROE), University of Edinburgh, Departamento de Fisica [Aveiro], Universidade de Aveiro, SRON Netherlands Institute for Space Research (SRON), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Department of Planetary Sciences [Tucson], University of Arizona, Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Lunar and Planetary Laboratory [Tucson] (LPL), Space Research Institute of Austrian Academy of Sciences (IWF), Austrian Academy of Sciences (OeAW), The Samuel Roberts Noble Foundation, Center for Human-Computer Interaction (HCI), Virginia Tech [Blacksburg], Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Centre for Astrophysics Research [Hatfield], University of Hertfordshire [Hatfield] (UH), ECLIPSE 2015, Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Physics and Astronomy [UCL London], Laboratoire de Physique Atmosphérique et Planétaire (LPAP), Université de Liège, Centro de Astronomia e Astrofísica da Universidade de Lisboa (CAAUL), Universidade de Lisboa = University of Lisbon (ULISBOA), Department of Physics and Astronomy [Uppsala], Uppsala University, Space Research Centre of Polish Academy of Sciences (CBK), Polska Akademia Nauk = Polish Academy of Sciences (PAN), Institute for Control Engineering of Machine Tools and Manufacturing Units (ISW), University of Stuttgart, Institute for Control Engineering of Machine Tools and Manufacturing Units (ISW), Department of Atmospheric, Oceanic and Planetary Physics [Oxford] (AOPP), University of Oxford, Mullard Space Science Laboratory (MSSL), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut Curie [Paris], Instituut voor Sterrenkunde [Leuven], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Centre for Behaviour and Evolution, Institute of Neuroscience, Newcastle University [Newcastle], foreign laboratories (FL), CERN [Genève], STFC Rutherford Appleton Laboratory (RAL), Science and Technology Facilities Council (STFC), Estrutura de Missão para a Extensão da Plataforma Continental, Estrutura de Missão para a Extensão para a Extensão da Plataforma Continental, Centre for Planetary Sciences [UCL/Birkbeck] (CPS), Queen Mary University of London (QMUL), Institut d'Astrophysique de Paris (IAP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Dark Cosmology Centre (DARK), Niels Bohr Institute [Copenhagen] (NBI), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH)-Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Computational Science and Engineering Department [Daresbury] (STFC), Science & Technologie Facilities Council, Departamento de Astrofisica [Madrid], Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Calar Alto Observatory, Centro Astronómico Hispano-Alemán, Department of Geoscience, Nelson Mandela University [Port Elizabeth], African Earth Observatory Network - Earth Stewardship Science Research Institute (AEON-ESSRI), Animal Genetics, Teagasc - The Agriculture and Food Development Authority (Teagasc), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Instituto Nacional de Engenharia, Tecnologia e Inovacao (INETI), Université Pierre et Marie Curie - Paris 6 (UPMC), CEA- Saclay (CEA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Università di Salerno - Dipartimento di Matematica, Università degli Studi di Salerno = University of Salerno (UNISA), Department of Genetics, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC)-Carolina Center for the Genome Sciences, Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Department of Molecular Medicine, Università degli Studi di Padova = University of Padua (Unipd), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), ASP 2015, Laboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux (L3AB), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Institute for Astronomy [Vienna], University of Vienna [Vienna], Institut de génétique et microbiologie [Orsay] (IGM), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Deutsches Forschungszentrum für Künstliche Intelligenz GmbH = German Research Center for Artificial Intelligence (DFKI), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Centro de Astrofísica da Universidade do Porto (CAUP), Universidade do Porto = University of Porto, Dipartimento di Matematica 'Ulisse Dini', Università degli Studi di Firenze = University of Florence (UniFI), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Université de Rennes (UR), Imperial College London, Laboratoire Hippolyte Fizeau (FIZEAU), School of Physics and Astronomy [Cardiff], Cardiff University, Institut d'Astrophysique et de Géophysique [Liège], Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), University of Bradford, Instituto Universitario de Electroquimica, Universidad de Alicante, Centre de recherche en éducation de Nantes (CREN), Le Mans Université (UM)-Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN), Departamento de Fisica Aplicada [Bilbao], Universidad del Pais Vasco / Euskal Herriko Unibertsitatea [Espagne] (UPV/EHU), NASA Goddard Space Flight Center (GSFC), Onsala Space Observatory (OSO), Chalmers University of Technology [Göteborg], Los Alamos National Laboratory (LANL), Osserv Astrofis Catania, Ist Nazl Astrofis, Centre d'Etude de l'Energie Nucléaire (SCK-CEN), Institut de Physique du Globe de Paris (IPGP (UMR_7154)), Institut national des sciences de l'Univers (INSU - CNRS)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Consejo Super Invest Cient, Inst Astrofis Andalucia, ES-18080 Granada, Spain, Department of Rheumatology (LEIDEN - Rhumato), Leiden University Medical Center (LUMC), Universiteit Leiden-Universiteit Leiden, Department of Rheumatology (COIMBRA - Rhumato), Universidade de Coimbra [Coimbra], Centre Scientifique et Technique du Bâtiment (CSTB), INAF - Osservatorio Astrofisico di Arcetri (OAA), Université de Bordeaux (UB), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique des gaz et des plasmas (LPGP), Pontificia Universidad Católica de Chile (UC), Department of Computer Science [Verona] (UNIVR | DI), Università degli studi di Verona = University of Verona (UNIVR), IEB-UNIVERSITY OF BARCELONA, Departamento de Física e Astronomia [Porto] (DFA/FCUP), Faculdade de Ciências da Universidade do Porto (FCUP), Universidade do Porto = University of Porto-Universidade do Porto = University of Porto, Thüringer Landessternwarte Tautenburg (TLS), Bremer Institut für Produktion und Logistik GmbH (BIBA), Universität Bremen, INAF - Osservatorio Astrofisico di Catania (OACT), Plasmon Nano-optics, Institut de Ciencies Fotoniques [Castelldefels] (ICFO), Royal Holloway [University of London] (RHUL), Hong Kong Government Environmental Protection Department, Water Policy and Science Group, National Space Agencies, Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Max Planck Institute for Solar System Research (MPS), European Space Agency (ESA), European Space Agency, Université Joseph Fourier - Grenoble 1 (UJF)-Commissariat à l'Énergie Atomique et aux Énergies Alternatives (CEA) - Grenoble-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Samuel Roberts Noble Foundation, Inc., Universidade de Lisboa (ULISBOA), Polska Akademia Nauk (PAN), University of Oxford [Oxford], Max-Planck-Institut für Sonnensystemforschung (MPS), Institut Curie, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Nelson Mandela Metropolitan University [Port Elizabeth, South Africa], AEON-ESSRI African Earth Observatory Network — Earth Stewardship Science Research Institute, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Instituto Nacional de Engenharia, Tecnologia e Inovacco (INETI), Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Université Francois Rabelais [Tours], Institut Français du Cheval et de l'Equitation, Università degli Studi di Salerno (UNISA), IRTA, Laboratoire d'astrophysique de l'observatoire de Besançon (LAOB), Universita degli Studi di Padova, Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Deutsches Forschungszentrum für Künstliche Intelligenz GmbH (DFKI), Universidade do Porto [Porto], Università degli Studi di Firenze [Firenze], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Department of Earth Sciences, University College London, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Centre interdisciplinaire de recherche, culture, éducation, formation, travail (CIRCEFT), Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), Station biologique, Centre National de la Recherche Scientifique (CNRS), Dipartimento di Informatica [Verona], Università degli Studi di Verona, Departamento de Física e Astronomia [Porto], UMR5116, Centre Émile Durkheim (CED), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Clinica Neurologica, Università degli Studi di Perugia (UNIPG), Rebordao, J. [0000-0002-7418-0345], Kerschbaum, F. [0000-0001-6320-0980], Abreu, M. [0000-0002-0716-9568], Tabernero, H. [0000-0002-8087-4298], López Puertas, M. [0000-0003-2941-7734], Jacquemoud, S. [0000-0002-1500-5256], Tennyson, J. [0000-0002-4994-5238], Focardi, M. [0000-0002-3806-4283], Leto, G. [0000-0002-0040-5011], Lodieu, N. [0000-0002-3612-8968], Tinetti, G. [0000-0001-6058-6654], Sanroma, E. [0000-0001-8859-7937], Poretti, E. [0000-0003-1200-0473], Deeg, H. [0000-0003-0047-4241], Grassi, D. [0000-0003-1653-3066], Piccioni, G. [0000-0002-7893-6808], Ribas, I. [0000-0002-6689-0312], Coates, A. [0000-0002-6185-3125], García Ramón, J. [0000-0002-8204-6832], Bouy, H. [0000-0002-7084-487X[, Lognonne, P. [0000-0002-1014-920X], Demangeon, O. [0000-0001-7918-0355], Morales, J. C. [0000-0003-0061-518X], Ray, T. [0000-0002-2110-1068], Guio, P. [0000-0002-1607-5862], Tanga, P. [0000-0002-2718-997X], Prisinzano, L. [0000-0002-8893-2210], Barstow, J. [0000-0003-3726-5419], Balado, A. [0000-0003-4268-2516], Lithgow Bertelloni, C. [0000-0003-0924-6587], Barton, E. [0000-0001-5945-9244], Delgado, M. E. [0000-0003-4434-2195], Affer, L. [0000-0001-5600-3778], Ciaravella, A. [0000-0002-3127-8078], Barrado Navascues, D. [0000-0002-5971-9242], Figueira, P. [0000-0001-8504-283X], Covino, E. [0000-0002-6187-6685], Venot, O. [0000-0003-2854-765X], Cabral, A. [0000-0002-9433-871X], Watson, D. [0000-0002-4465-8264], Morales Calderon, M. [0000-0001-9526-9499], Ward Thompson, D. [0000-0003-1140-2761], Rebolo, R. [0000-0003-3767-7085], López Valverde, M. A. [0000-0002-7989-4267], Gillon, M. [0000-0003-1462-7739], Morgante, G. [0000-0001-9234-7412], Zapatero Osorio, M. R. [0000-0001-5664-2852], Bulgarelli, A. [0000-0001-6347-0649], Pena Ramírez, K. [0000-0002-5855-401X], Galand, M. [0000-0001-5797-914X], Pancrazzi, M. [0000-0002-3789-2482], Malaguti, G. [0000-0001-9872-3378], Sánchez Lavega, A. [0000-0001-7234-7634], Waldmann, I. [0000-0002-4205-5267], Kovacs, G. [0000-0002-2365-2330], Guillot, T. [0000-0002-7188-8428], Turrini, D. [0000-0002-1923-7740], Altieri, F. [0000-0002-6338-8300], Bellucci, G. [0000-0003-0867-8679], Baffa, C. [0000-0002-4935-100X], Olivia, E. [0000-0002-9123-0412], Selsis, F. [0000-0001-9619-5356], Scuderi, Salvatore [0000-0002-8637-2109], Hersant, F. [0000-0002-2687-7500], Gear, W. [0000-0001-6789-6196], Damasso, M. [0000-0001-9984-4278], Tizzi, A. [0000-0002-6725-3825], Pinfield, D. [0000-0002-7804-4260], Kipping, D. [0000-0002-4365-7366], Maldonado, J. [0000-0002-4282-1072], Pace, E. [0000-0001-5870-1772], Burleigh, M. [0000-0003-0684-7803], Monteiro, M. [0000-0001-5644-0898], Pilat Lohinger, E. [0000-0002-5292-1923], Chadney, J. [0000-0002-5174-2114], Moro Martín, A. [0000-0001-9504-8426], Claret, A. [0000-0002-4045-8134], Gómez, H. [0000-0003-3398-0052], Maldonado, J. [0000-0002-2218-5689], Michaut, C. [0000-0002-2578-0117], Hornstrup, A. [0000-0002-3363-0936], Scholz, A. [0000-0001-8993-5053], Irwin, P. [0000-0002-6772-384X], Bezard, B. [0000-0002-5433-5661], López Heredero, R. [0000-0002-2197-8388], Sanz Forcada, J. [0000-0002-1600-7835], Danielski, C. [0000-0002-3729-2663], Sousa, S. [0000-0001-9047-2965], Medved, A. [0000-0003-2713-8977], Bakos, G. [0000-0001-7204-6727], Ade, P. [0000-0002-5127-0401], Vandenbussche, B. [0000-0002-1368-3109], Martín Torres, J. [0000-0001-6479-2236], Correira, A. [0000-0002-8946-8579], Haigh, J. [0000-0001-5504-4754], Scandariato, G. [0000-0003-2029-0626], Guedel, M. [0000-0001-9818-0588], Sánchez Bejar, V. [0000-0002-5086-4232], Rodríguez, P. [0000-0002-6855-9682], Piskunov, N. [0000-0001-5742-7767], Adibekyan, V. [0000-0002-0601-6199], Pérez Hoyos, S. [0000-0001-9797-4917], Kervella, P. [0000-0003-0626-1749], Pascale, E. [0000-0002-3242-8154], Claudi, R. [0000-0001-7707-5105], Filacchione, G. [0000-0001-9567-0055], Rickman, H. [0000-0002-9603-6619], Amado, P. J. [0000-0002-8388-6040], Maggio, A. [0000-0001-5154-6108], Agundez, M. [0000-0003-3248-3564], Montes, D. [0000-0002-7779-238X], Fletcher, L. [0000-0001-5834-9588], Stixrude, L. [0000-0003-3778-2432], Morais, M. H. [0000-0001-5333-2736], Hueso, R. [0000-0003-0169-123X], Yurchenko, S. [0000-0001-9286-9501], Rataj, M. [0000-0002-2978-9629], Pérez Hoyos, S. [0000-0002-2587-4682], Santos, N. [0000-0003-4422-2919], Peralta, J. [0000-0002-6823-1695], Budaj, J. [0000-0002-9125-7340], Barlow, M. [0000-0002-3875-1171], Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École des Ponts ParisTech (ENPC)-École polytechnique (X)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Universidade do Porto, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), University of Verona (UNIVR), Universidade do Porto-Universidade do Porto, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université de Nantes - UFR Lettres et Langages (UFRLL), Université de Nantes (UN)-Université de Nantes (UN)-Le Mans Université (UM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris)-Centre National de la Recherche Scientifique (CNRS)-École des Ponts ParisTech (ENPC)-École polytechnique (X)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Firenze = University of Florence [Firenze], COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, University College of London [London] ( UCL ), Laboratoire d'études spatiales et d'instrumentation en astrophysique ( LESIA ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Max Planck Institute for Solar System Research ( MPS ), School of Physics & Astronomy, European Space Agency ( ESA ), INAF - Osservatorio Astronomico di Palermo ( OAPa ), Istituto Nazionale di Astrofisica ( INAF ), Laboratoire des technologies de la microélectronique ( LTM ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation ( IMEP-LAHC ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -Institut National Polytechnique de Grenoble ( INPG ) -Université Savoie Mont Blanc ( USMB [Université de Savoie] [Université de Chambéry] ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Universidad Politécnica de Cataluña, U.S. Army Research Laboratory [Adelphi, MD] ( ARL ), United States Army ( U.S. Army ), Royal Observatory Edinburgh ( ROE ), SRON Netherlands Institute for Space Research ( SRON ), Laboratoire de Météorologie Dynamique (UMR 8539) ( LMD ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -École polytechnique ( X ) -École des Ponts ParisTech ( ENPC ) -Centre National de la Recherche Scientifique ( CNRS ) -Département des Géosciences - ENS Paris, École normale supérieure - Paris ( ENS Paris ) -École normale supérieure - Paris ( ENS Paris ), Joseph Louis LAGRANGE ( LAGRANGE ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Observatoire de la Côte d'Azur, Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Lunar and Planetary Laboratory [Tucson], Space Research Institute of Austrian Academy of Sciences ( IWF ), Austrian Academy of Sciences ( OeAW ), Centre de Recherche Astrophysique de Lyon ( CRAL ), École normale supérieure - Lyon ( ENS Lyon ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Center for Human-Computer Interaction ( HCI ), Istituto di Astrofisica e Planetologia Spaziali ( IAPS ), University of Hertfordshire [Hatfield] ( UH ), Laboratoire d'Astrophysique de Bordeaux [Pessac] ( LAB ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Atmosphérique et Planétaire ( LPAP ), Centro de Astronomia e Astrofísica da Universidade de Lisboa ( CAAUL ), Universidade de Lisboa ( ULISBOA ), Space Research Centre [Warsaw] ( CBK ), Polska Akademia Nauk ( PAN ), Department of Atmospheric, Oceanic and Planetary Physics [Oxford] ( AOPP ), Mullard Space Science Laboratory ( MSSL ), Max-Planck-Institut für Sonnensystemforschung ( MPS ), Institut de Recherches sur les lois Fondamentales de l'Univers ( IRFU ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Instituut voor Sterrenkunde, Katholieke Universiteit Leuven ( KU Leuven ), foreign laboratories ( FL ), STFC Rutherford Appleton Laboratory ( RAL ), Science and Technology Facilities Council ( STFC ), Centre for Planetary Sciences [UCL/Birkbeck] ( CPS ), Queen Mary University of London ( QMUL ), Institut d'Astrophysique de Paris ( IAP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Dark Cosmology Center, Niels Bohr Institute, University of Copenhagen ( KU ), Computational Science and Engineering Department [Daresbury] ( STFC ), LAEX, Depto. Astrofísica, Centro de Astrobiología, Nelson Mandela Metropolitan University, Nelson Mandela Metropolitan University [Port Elizabeth, South Africa]-Nelson Mandela Metropolitan University [Port Elizabeth, South Africa], Teagasc, Laboratoire d'Astrophysique de Marseille ( LAM ), Aix Marseille Université ( AMU ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National d'Etudes Spatiales ( CNES ) -Centre National de la Recherche Scientifique ( CNRS ), Fraunhofer-Institute for Applied Solid-State Physics (IAF), Centro de Astrobiologia [Madrid] ( CAB ), Instituto Nacional de Técnica Aeroespacial ( INTA ) -Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), Instituto Nacional de Engenharia, Tecnologia e Inovacco ( INETI ), INETI, Université Pierre et Marie Curie - Paris 6 ( UPMC ), Physiologie de la reproduction et des comportements [Nouzilly] ( PRC ), Institut National de la Recherche Agronomique ( INRA ) -Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique ( CNRS ), Università degli Studi di Salerno ( UNISA ), The University of North Carolina at Chapel Hill-Carolina Center for the Genome Sciences, Laboratoire d'astrophysique de l'observatoire de Besançon ( LAOB ), Université de Franche-Comté ( UFC ), Universita degli Studi di Padova = University of Padua = Université de Padoue, Institut d'astrophysique spatiale ( IAS ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux ( L3AB ), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Observatoire aquitain des sciences de l'univers ( OASU ), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Laboratoire d'Astrophysique de Bordeaux [Pessac] ( LAB ), Université de Bordeaux ( UB ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ), Institut de génétique et microbiologie [Orsay] ( IGM ), Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Deutsches Forschungszentrum für Künstliche Intelligenz GmbH ( DFKI ), Consejo Nacional de Investigaciones Científicas y Técnicas ( CONICET ), Centro de Astrofísica da Universidade do Porto ( CAUP ), Institut Universitaire de France ( IUF ), Ministère de l'Éducation nationale, de l’Enseignement supérieur et de la Recherche ( M.E.N.E.S.R. ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ), Laboratoire Hippolyte Fizeau ( FIZEAU ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de la Côte d'Azur, Istituto di Fisica dello Spazio Interplanetario CNR (IFSI), Laboratoire de l'Accélérateur Linéaire ( LAL ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de recherche en éducation de Nantes ( CREN ), Université de Nantes ( UN ), Universidad del Pais Vasco / Euskal Herriko Unibertsitatea ( UPV/EHU ), NASA Goddard Space Flight Center ( GSFC ), Onsala Space Observatory ( OSO ), Los Alamos National Laboratory ( LANL ), Centre d'Etude de l'Energie Nucléaire ( SCK-CEN ), Institut de Physique du Globe de Paris ( IPGP ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -IPG PARIS-Université Paris Diderot - Paris 7 ( UPD7 ) -Université de la Réunion ( UR ) -Centre National de la Recherche Scientifique ( CNRS ), Instituto de Astrofísica de Andalucía ( IAA ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Department of Rheumatology ( LEIDEN - Rhumato ), Department of Rheumatology ( COIMBRA - Rhumato ), Centre Scientifique et Technique du Bâtiment ( CSTB ), INAF - Osservatorio Astrofisico di Arcetri ( OAA ), Centre interdisciplinaire de recherche, culture, éducation, formation, travail ( CIRCEFT ), Université Paris 8 Vincennes-Saint-Denis ( UP8 ) -Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Institut national des sciences de l'Univers ( INSU - CNRS ) -IPG PARIS-Université Paris Diderot - Paris 7 ( UPD7 ) -Université de la Réunion ( UR ) -Centre National de la Recherche Scientifique ( CNRS ), Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de physique des gaz et des plasmas ( LPGP ), Pontificia Universidad Católica de Chile, Thüringer Landessternwarte Tautenburg ( TLS ), BIBA Bremer Institut für Produktion und Logistik GmbH, Centre Émile Durkheim ( CED ), Université de Bordeaux ( UB ) -Sciences Po-Centre National de la Recherche Scientifique ( CNRS ) -Université de Bordeaux ( UB ) -Sciences Po-Centre National de la Recherche Scientifique ( CNRS ), INAF - Osservatorio Astrofisico di Catania ( OACT ), Institut de Ciencies Fotoniques [Castelldefels] ( ICFO ), Università di Perugia, Royal Holloway [University of London] ( RHUL ), and Low Energy Astrophysics (API, FNWI)
Subjects: Astrofísica, Solar System, Computer science, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], HOT-JUPITER ATMOSPHERES, 7. Clean energy, Space missions, law.invention, Astronomi, astrofysik och kosmologi, Planet, law, Observatory, Astronomy, Astrophysics and Cosmology, Transit (astronomy), Atmospheric science, Exoplanets, IR astronomy, Spectroscopy, Astronomy and Astrophysics, Space and Planetary Science, QC, QB, Eclipse, Earth and Planetary Astrophysics (astro-ph.EP), education.field_of_study, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], [ SDU.ASTR.EP ] Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Exoplanet, GIANT PLANETS, Physical Sciences, ENERGY-BALANCE, Astrophysics::Earth and Planetary Astrophysics, Population, MU-M, FOS: Physical sciences, F500, Astronomy & Astrophysics, Telescope, INFRARED-EMISSION-SPECTRUM, education, [ SDU.ASTR ] Sciences of the Universe [physics]/Astrophysics [astro-ph], EXTRASOLAR PLANET ATMOSPHERE, Science & Technology, Astronomy, EXOPLANET HD 189733B, HUBBLE-SPACE-TELESCOPE, Astronomía, TRANSMISSION SPECTROSCOPY, 0201 Astronomical And Space Sciences, 13. Climate action, WATER-VAPOR, astro-ph.EP, Astrophysics - Earth and Planetary Astrophysics
Abstract: The discovery of almost 2000 exoplanets has revealed an unexpectedly diverse planet population. Observations to date have shown that our Solar System is certainly not representative of the general population of planets in our Milky Way. The key science questions that urgently need addressing are therefore: What are exoplanets made of? Why are planets as they are? What causes the exceptional diversity observed as compared to the Solar System? EChO (Exoplanet Characterisation Observatory) has been designed as a dedicated survey mission for transit and eclipse spectroscopy capable of observing a large and diverse planet sample within its four-year mission lifetime. EChO can target the atmospheres of super-Earths, Neptune-like, and Jupiter-like planets, in the very hot to temperate zones (planet temperatures of 300K-3000K) of F to M-type host stars. Over the next ten years, several new ground- and space-based transit surveys will come on-line (e.g. NGTS, CHEOPS, TESS, PLATO), which will specifically focus on finding bright, nearby systems. The current rapid rate of discovery would allow the target list to be further optimised in the years prior to EChO's launch and enable the atmospheric characterisation of hundreds of planets. Placing the satellite at L2 provides a cold and stable thermal environment, as well as a large field of regard to allow efficient time-critical observation of targets randomly distributed over the sky. A 1m class telescope is sufficiently large to achieve the necessary spectro-photometric precision. The spectral coverage (0.5-11 micron, goal 16 micron) and SNR to be achieved by EChO, thanks to its high stability and dedicated design, would enable a very accurate measurement of the atmospheric composition and structure of hundreds of exoplanets., Comment: 50 pages, 30 figures. Experimental Astronomy
Published: 2015

7. Quality of life measurement in rosacea. Position statement of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

Author: P. V. Chernyshov, A. Y. Finlay, L. Tomas‐Aragones, M. Steinhoff, L. Manolache, N. Pustisek, C. Dessinioti, A. Svensson, S. E. Marron, A. Bewley, C. Salavastru, B. Dréno, A. Suru, D. Koumaki, D. Linder, A. W. M. Evers, D. Abeni, M. Augustin, S. S. Salek, A. Nassif, V. Bettoli, J. С. Szepietowski, C. C. Zouboulis, Université de Kiev, Cardiff University, University of Zaragoza - Universidad de Zaragoza [Zaragoza], Hamad Medical Corporation [Doha, Qatar], Weill Cornell Medicine [Qatar], Qatar University, Weill Cornell Medicine [Cornell University], Cornell University [New York], Dali Medical, Partenaires INRAE, Children’s Hospital Srebrnjak [Zagreb, Croatia], University of Athens Medical School [Athens], Skane University Hospital [Malmo], Lund University [Lund], Royo Villanova Hospital, Whipps Cross University Hospital, University of Medicine and Pharmacy 'Carol Davila' Bucharest (UMPCD), Immunology and New Concepts in ImmunoTherapy (INCIT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), University of Crete [Heraklion] (UOC), Medical University of Graz, Universiteit Leiden, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] (UKE), University of Hertfordshire [Hatfield] (UH), Institut Pasteur [Paris] (IP), Università degli Studi di Ferrara = University of Ferrara (UniFE), Wrocław Medical University, and Medizinische Hochschule Brandenburg Theodor Fontane / Brandenburg Medical School Theodor-Fontane (MHB Theodor Fontane)
Subjects: Infectious Diseases, [SDV]Life Sciences [q-bio], Dermatology
Abstract: The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient-Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa (ARHS) do not recommend the use of any generic instrument as a single method of Health Related (HR) QoL assessment in rosacea, except when comparing quimp (quality of life impairment) in rosacea patients with that in other non-dermatologic skin diseases and/or healthy controls. The EADV TFs on QoL and Patient-Oriented Outcomes and ARHS recommend the use of the dermatology-specific HRQoL instrument the Dermatology Life Quality Index (DLQI) and the rosacea-specific HRQoL instrument RosaQoL in rosacea patients. The DLQI minimal clinically important difference may be used as a marker of clinical efficacy of the treatment and DLQI score banding of 0 or 1 corresponding to no effect on patients' HRQoL could be an important treatment goal. This information may be added to consensuses and guidelines for rosacea.
Published: 2023

8. Ultracool dwarfs in Gaia DR3

Author: L. M. Sarro, A. Berihuete, R. L. Smart, C. Reylé, D. Barrado, M. García-Torres, W. J. Cooper, H. R. A. Jones, F. Marocco, O. L. Creevey, R. Sordo, C. A. L. Bailer-Jones, P. Montegriffo, R. Carballo, R. Andrae, M. Fouesneau, A. C. Lanzafame, F. Pailler, F. Thévenin, A. Lobel, L. Delchambre, A. J. Korn, A. Recio-Blanco, M. S. Schultheis, F. De Angeli, N. Brouillet, L. Casamiquela, G. Contursi, P. de Laverny, P. García-Lario, G. Kordopatis, Y. Lebreton, E. Livanou, A. Lorca, P. A. Palicio, I. Slezak-Oreshina, C. Soubiran, A. Ulla, H. Zhao, University of Cadiz, INAF - Osservatorio Astrofisico di Torino (OATo), Istituto Nazionale di Astrofisica (INAF), Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules (UMR 6213) (UTINAM), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), OSU-THETA - Observatoire des Sciences de l'Univers - Terre Homme Environnement Temps Astronomie (OSU-THETA), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), European Space Astronomy Centre (ESAC), Agence Spatiale Européenne = European Space Agency (ESA), Centre for Astrophysics Research [Hatfield], University of Hertfordshire [Hatfield] (UH), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Padova (OAPD), INAF - Osservatorio Astronomico di Bologna (OABO), Max Planck Institute for Astronomy (MPIA), Max-Planck Institute for Astronomy, Konigstuhl 17, D-69117, Heidelberg, Germany, Centre National d'Études Spatiales [Toulouse] (CNES), Royal Observatory of Belgium [Brussels] (ROB), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut de Physique de Rennes (IPR), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Earth and Planetary Astrophysics (astro-ph.EP), stars, pre-main sequence, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, methods, Astrophysics - Solar and Stellar Astrophysics, Astronomi, astrofysik och kosmologi, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Astrophysics of Galaxies (astro-ph.GA), low-mass, Hertzsprung-Russell and C-M diagrams, Astronomy, Astrophysics and Cosmology, late-type, statistical, Solar and Stellar Astrophysics (astro-ph.SR), Astrophysics - Earth and Planetary Astrophysics, brown dwarfs
Abstract: Aims. In this work we use the Gaia DR3 set of ultracool dwarf candidates and complement the Gaia spectrophotometry with additional photometry in order to characterise its global properties. This includes the inference of the distances, their locus in the Gaia colour-absolute magnitude diagram and the (biased through selection) luminosity function in the faint end of the Main Sequence. We study the overall changes in the Gaia RP spectra as a function of spectral type. We study the UCDs in binary systems, attempt to identify low-mass members of nearby young associations, star forming regions and clusters, and analyse their variability properties. Results. We detect 57 young, kinematically homogeneous groups some of which are identified as well known star forming regions, associations and clusters of different ages. We find that the primary members of 880 binary systems with a UCD belong mainly to the thin and thick disk components of the Milky Way. We identify 1109 variable UCDs using the variability tables in the Gaia archive, 728 of which belong to the star forming regions defined by HMAC. We define two groups of variable UCDs with extreme bright or faint outliers. Conclusions. The set of sources identified as UCDs in the Gaia archive contains a wealth of information that will require focused follow-up studies and observations. It will help to advance our understanding of the nature of the faint end of the Main Sequence and the stellar/substellar transition., Accepted by Astronomy and Astrophysics. 29 pages, 20 figures plus 3 appendices
Published: 2023

9. 'The People's Summit': A case for lived experience of food environments as a critical source of evidence to inform the follow-up to the 2021 UN Food Systems Summit

Author: M. Spires, J. Battersby, N. Cohen, M. Daivadanam, K.M. Demmler, D. Mattioni, R. Pradeilles, C. Thompson, C. Turner, C. Venegas Hargous, S. Wertheim-Heck, W. Wills, C. Hawkes, City University of London, University of Cape Town, City University of New York [New York] (CUNY), Uppsala University, Global Alliance for Improved Nutrition (GAIN), University of Pisa - Università di Pisa, Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) (UMR MoISA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), University of Hertfordshire [Hatfield] (UH), University of Greenwich, Deakin University, Burwood, Australia, Deakin University [Burwood], Wageningen University and Research [Wageningen] (WUR), and Food and Agriculture Organization of the United Nations [Rome, Italie] (FAO)
Subjects: Participatory research, Milieubeleid, Nutrition and Dietetics, UN Food Systems Summit, Ecology, Food policy, Public Health, Global Health, Social Medicine and Epidemiology, WASS, Environmental Policy, Näringslära, Lived experience research, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Life Science, Safety, Risk, Reliability and Quality, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Safety Research, Food Science
Abstract: International audience
Published: 2023

10. Chronos: A NIR spectroscopic galaxy survey to probe the most fundamental stages of galaxy evolution

Author: Stéphane Charlot, Anna Pasquali, Jonathan Bland-Hawthorn, Christopher J. Conselice, Stephen Serjeant, Andrew M. Hopkins, James Dunlop, Gustavo Bruzual, Thomas D. Kitching, Rogier A. Windhorst, Simon P. Driver, Sugata Kaviraj, Ignacio Ferreras, Ofer Lahav, Ray M. Sharples, Mark Cropper, Joseph Silk, F. La Barbera, University College of London [London] (UCL), Instituto de Astrofisica de Canarias (IAC), Universidad de La Laguna [Tenerife - SP] (ULL), Mullard Space Science Laboratory (MSSL), Duke University [Durham], The University of Sydney, Universidad Nacional Autónoma de México (UNAM), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Manchester [Manchester], The University of Western Australia (UWA), University of Edinburgh, Macquarie University, University of Hertfordshire [Hatfield] (UH), INAF - Osservatorio Astronomico di Capodimonte (OAC), Istituto Nazionale di Astrofisica (INAF), UniversitätsKlinikum Heidelberg, The Open University [Milton Keynes] (OU), University of Oxford [Oxford], Johns Hopkins University (JHU), and Arizona State University [Tempe] (ASU)
Subjects: Physics, Stellar kinematics, COSMIC cancer database, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], 010308 nuclear & particles physics, Near-infrared spectroscopy, Continuum (design consultancy), Instrumentation:spectrographs, Galaxies: evolution, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Galaxies: formation, 01 natural sciences, Redshift, Galaxy, Physical cosmology, Space and Planetary Science, 0103 physical sciences, Galaxy formation and evolution, Space vehicles: instruments, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Telescopes
Abstract: We propose a dedicated, ultra-deep spectroscopic survey in the near infrared (NIR), that will target a mass-limited sample of galaxies during two of the most fundamental epochs of cosmic evolution: the formation of the first galaxies (at z $\gtrsim $ ≳ 6; cosmic dawn), and at the peak of galaxy formation activity (at redshift z$\sim $ ∼ 1–3; cosmic noon). By way of NIR observations (λ= 0.8–2μ m), it is possible to study the UV Lyman-α region in the former, and the optical rest-frame in the latter, allowing us to extract fundamental observables such as gas and stellar kinematics, chemical abundances, and ages, providing a unique legacy database covering these two crucial stages of cosmic evolution. The need to work in the NIR at extremely low flux levels makes a ground-based approach unfeasible due to atmospheric emission and absorption. Only with the largest facilities of the future (e.g. ELT) will be possible to observe a reduced set of targets, comprising at most of order thousands of galaxies. Likewise, from space, the small field of view of JWST and its use as a general purpose facility will yield a rather small set of high quality NIR spectra of distant galaxies (in the thousands, at best). Our project (codename ) aims to produce $\sim $ ∼ 1 million high quality spectra, with a high S/N in the continuum, where information about the underlying stellar populations is encoded. The main science drivers are: The connection between the star formation history and the mass assembly history. The role of AGN and supernova feedback in shaping the formation histories of galaxies, with a quantitative estimate of quenching timescales. The formation of the first galaxies. The source of reionization. Evolution of the metallicity-mass relation, including [α/Fe] and individual abundances. Precision cosmology through detailed studies of the “baryon physics” of galaxy formation, probing the power spectrum over scales k$\sim $ ∼ 1 Mpc− 1.
Published: 2021

11. Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis

Author: James M Gwinnutt, Sam Norton, Kimme L Hyrich, Mark Lunt, Bernard Combe, Nathalie Rincheval, Adeline Ruyssen-Witrand, Bruno Fautrel, Daniel F McWilliams, David A Walsh, Elena Nikiphorou, Patrick D W Kiely, Adam Young, Jacqueline R Chipping, Alex MacGregor, Suzanne M M Verstappen, Gestionnaire, HAL Sorbonne Université 5, University of Manchester [Manchester], King‘s College London, Manchester University NHS Foundation Trust (MFT), Université de Montpellier (UM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service de Rhumatologie [CHU Pitié Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Pharmacoépidémiologie et évaluation des soins [iPLesp] (PEPITES), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), University of Nottingham, UK (UON), St George’s University Hospitals, University of Hertfordshire [Hatfield] (UH), and University of East Anglia [Norwich] (UEA)
Subjects: Inflammation, [SDV]Life Sciences [q-bio], Pain, Antirheumatic Agents/therapeutic use, Severity of Illness Index, Biomedical Research Centre, Arthritis, Rheumatoid, [SDV] Life Sciences [q-bio], Disability Evaluation, Rheumatology, Arthritis, Rheumatoid/drug therapy, Pain/drug therapy, Antirheumatic Agents, Inflammation/drug therapy, Humans, Fatigue/drug therapy, Female, Pharmacology (medical), Prospective Studies, Arthritis Research Campaign National Pain Centre, Medical Science, Fatigue
Abstract: Objectives To identify groups of people with RA with different disability trajectories over 10 years, despite comparable levels of inflammation. Methods Data for this analysis came from three European prospective cohort studies of people with RA [Norfolk Arthritis Register (NOAR), Early RA Network (ERAN), Étude et Suivi des Polyarthrites Indifférenciées Récentes (ESPOIR)]. Participants were assessed regularly over 8 (ERAN) to 10 (NOAR/ESPOIR) years. Inclusion criteria were: recruited after 1 January 2000, Results This analysis included 2500 people with RA (NOAR: 1000, ESPOIR: 766, ERAN: 734). ESPOIR included more women and the participants were younger [mean (standard deviation) age: NOAR: 57.1 (14.6), ESPOIR: 47.6 (12.5), ERAN: 56.8 (13.8); women: NOAR: 63.9%, ESPOIR: 76.9%, ERAN: 69.1%). Within each cohort, two pairs of trajectories following the hypothesized pattern (comparable DAS28-2Cs but different HAQs) were identified. Higher pain, fatigue and depressive symptoms were associated with increased odds of being in the high HAQ trajectories. Conclusion Excess disability is persistent in RA. Controlling inflammation may not be sufficient to alleviate disability in all people with RA, and effective pain, fatigue and mood management may be needed in some groups to improve long-term function.
Published: 2022

12. Mere end lugtesans - COVID-19 er associeret med svær påvirkning af lugtesansen, smagssansen og mundfølelsen

Author: Parma, Valentina, Ohla, Kathrin, Veldhuizen, Maria G, Niv, Masha Y, Kelly, Christine E, Bakke, Alyssa J, Cooper, Keiland W, Bouysset, Cédric, Pirastu, Nicola, Dibattista, Michele, Kaur, Rishemjit, Liuzza, Marco Tullio, Pepino, Marta Y, Schöpf, Veronika, Pereda-Loth, Veronica, Olsson, Shannon B, Gerkin, Richard C, Rohlfs Domínguez, Paloma, Albayay, Javier, Farruggia, Michael C, Bhutani, Surabhi, Fjaeldstad, Alexander W, Kumar, Ritesh, Menini, Anna, Bensafi, Moustafa, Sandell, Mari, Konstantinidis, Iordanis, Di Pizio, Antonella, Genovese, Federica, Öztürk, Lina, Thomas-Danguin, Thierry, Frasnelli, Johannes, Boesveldt, Sanne, Saatci, Özlem, Saraiva, Luis R, Lin, Cailu, Golebiowski, Jérôme, Hwang, Liang-Dar, Ozdener, Mehmet Hakan, Guàrdia, Maria Dolors, Laudamiel, Christophe, Ritchie, Marina, Havlícek, Jan, Pierron, Denis, Roura, Eugeni, Navarro, Marta, Nolden, Alissa A, Lim, Juyun, Whitcroft, Katherine L, Colquitt, Lauren R, Ferdenzi, Camille, Brindha, Evelyn V, Altundag, Aytug, Macchi, Alberto, Nunez-Parra, Alexia, Patel, Zara M, Fiorucci, Sébastien, Philpott, Carl M, Smith, Barry C, Lundström, Johan N, Mucignat, Carla, Parker, Jane K, van den Brink, Mirjam, Schmuker, Michael, Fischmeister, Florian Ph S, Heinbockel, Thomas, Shields, Vonnie D C, Faraji, Farhoud, Santamaría, Enrique, Fredborg, William E A, Morini, Gabriella, Olofsson, Jonas K, Jalessi, Maryam, Karni, Noam, D’Errico, Anna, Alizadeh, Rafieh, Pellegrino, Robert, Meyer, Pablo, Huart, Caroline, Chen, Ben, Soler, Graciela M, Alwashahi, Mohammed K, Welge-Lüssen, Antje, Freiherr, Jessica, de Groot, Jasper H B, Klein, Hadar, Okamoto, Masako, Singh, Preet Bano, Hsieh, Julien W, Abdulrahman, Olagunju, Dalton, Pamela, Yan, Carol H, Voznessenskaya, Vera V, Chen, Jingguo, Sell, Elizabeth A, Walsh-Messinger, Julie, Archer, Nicholas S, Koyama, Sachiko, Deary, Vincent, Roberts, S Craig, Yanık, Hüseyin, Albayrak, Samet, Nováková, Lenka Martinec, Croijmans, Ilja, Mazal, Patricia Portillo, Moein, Shima T, Margulis, Eitan, Mignot, Coralie, Mariño, Sajidxa, Georgiev, Dejan, Kaushik, Pavan K, Malnic, Bettina, Wang, Hong, Seyed-Allaei, Shima, Yoluk, Nur, Razzaghi-Asl, Sara, Justice, Jeb M, Restrepo, Diego, Reed, Danielle R, Hummel, Thomas, Munger, Steven D, Hayes, John E, Indústries Alimentàries, Qualitat i Tecnologia Alimentària, Tecnologia Alimentària, Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association, Mersin University, The Hebrew University of Jerusalem (HUJ), AbScent, Pennsylvania State University (Penn State), Penn State System, University of California [Irvine] (UC Irvine), University of California (UC), Université Côte d'Azur (UCA), University of Edinburgh, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Central Scientific Instruments Organisation (CSIR), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), University of Illinois at Urbana-Champaign [Urbana], University of Illinois System, Medizinische Universität Wien = Medical University of Vienna, Groupement scientifique de Biologie et de Medecine Spatiale (GSBMS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES), Tata Institute for Fundamental Research (TIFR), Arizona State University [Tempe] (ASU), Universidad de Extremadura - University of Extremadura (UEX), Università degli Studi di Padova = University of Padua (Unipd), Yale School of Medicine [New Haven, Connecticut] (YSM), San Diego State University (SDSU), Aarhus University [Aarhus], University of Hertfordshire [Hatfield] (UH), Scuola Internazionale Superiore di Studi Avanzati / International School for Advanced Studies (SISSA / ISAS), Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Turku, Aristotle University of Thessaloniki, Leibniz-Institute for Food Systems Biology at the Technical University of Munich, Monell Chemical Senses Center, Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Montréal (UdeM), Wageningen University and Research Centre (WUR), Medical Science University, Sidra Medicine [Doha, Qatar], Institut de Chimie de Nice (ICN), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), University of Southern Queensland (USQ), Institut de Recerca i Tecnologia Agroalimentàries = Institute of Agrifood Research and Technology (IRTA), DreamAir Llc, Charles University [Prague] (CU), Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Massachusetts System (UMASS), Oregon State University (OSU), Ear Institute, UCL, Lyon Neuroscience Research center, Karunya University, Biruni University, Assi Sette Llaghi Varese, Stanford School of Medicine [Stanford], Stanford Medicine, Stanford University-Stanford University, University of East Anglia [Norwich] (UEA), California Department of Food and Agriculture (CDFA), Unité mixte de recherche interactions plantes-microorganismes, Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Maastricht University [Maastricht], Institute for Biology - Neurobiology, Freie Universität Berlin, Karl-Franzens-Universität Graz, Howard University College of Medicine, Towson University, University of California [San Diego] (UC San Diego), Proteomics, Center for Applied Medical Research (CIMA), Stockholm University, University of Gastronomic Sciences, Iran University of Medical Sciences, Goethe Universität Frankfurt, University of Tennessee, IBM T.J. Watson Research Center, Université libre de Bruxelles (ULB), Guangzhou Medical University, Buenos Aires University and GEOG (Grupo de Estudio de Olfato y Gusto), Sultan Qaboos University (SQU), Federal University of Technology of Akure (FUTA), A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences [Moscow] (RAS), Hospital of Xi'an Jiaotong University, University of Pennsylvania, University of Dayton, CSIRO Agriculture and Food (CSIRO), Indiana University [Bloomington], Indiana University System, University of Northumbria at Newcastle [United Kingdom], University of Stirling, Middle East Technical University [Ankara] (METU), Utrecht University [Utrecht], Instituto Universitario del Hospital Italiano [Buenos Aires, Argentina], Institute for Research in Fundamental Sciences [Tehran] (IPM), Hebrew University of Jerusalem, Technische Universität Dresden = Dresden University of Technology (TU Dresden), Terrazas del Club Hipico, University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Tata Institute of Fundamental Research [Bangalore], Universidade de São Paulo = University of São Paulo (USP), University of Florida [Gainesville] (UF), University of Colorado Anschutz [Aurora], Center for Smell and Taste, Department of Food Science, Pennsylvania State University., Julien, Sabine, Tıp Fakültesi, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service d'oto-rhino-laryngologie, Department of Food and Nutrition, Senses and Food, Research Center Jülich, University of California [Irvine] (UCI), University of California, Università degli studi di Bari Aldo Moro (UNIBA), Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), University of Extremadura, University of Padova, Yale University School of Medicine, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, University of Helsinki, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institute of Agrifood Research and Technology (IRTA), Universita degli Studi di Padova, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Karl-Franzens-Universität [Graz, Autriche], University of California San Diego Health, University of Brussels, University of Pennsylvania [Philadelphia], Tata Institute of Fundamental Research, University of São Paulo (USP), UCL - SSS/IONS - Institute of NeuroScience, FSE Campus Venlo, and RS: FSE UCV
Subjects: Male, Taste, Physiology, Smagstab, Audiology, AcademicSubjects/SCI01180, Settore BIO/09 - Fisiologia, Behavioral Neuroscience, chemistry.chemical_compound, Olfaction Disorders, Taste Disorders, 0302 clinical medicine, RATINGS, Hyposmia, Surveys and Questionnaires, CHEMOSENSITIVITY, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Viral, PALADAR, 030223 otorhinolaryngology, Sensory Science and Eating Behaviour, media_common, TASTE, US NATIONAL-HEALTH, [SDV.IDA] Life Sciences [q-bio]/Food engineering, Middle Aged, Biological Sciences, 16. Peace & justice, Sensory Systems, 3. Good health, Smell, GCCR Group Author, ddc:540, Smell loss, Female, Original Article, medicine.symptom, Corrigendum, Coronavirus Infections, olfaction, Adult, somatosensation, medicine.medical_specialty, 663/664, Coronavirus disease 2019 (COVID-19), OLFACTORY DISORDERS, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), media_common.quotation_subject, Pneumonia, Viral, head and neck surgery, Aged, Betacoronavirus, COVID-19, Humans, Pandemics, SARS-CoV-2, Self Report, Somatosensory Disorders, Young Adult, Anosmia, Sensory system, Olfaction, 03 medical and health sciences, Chemesthesis, Physiology (medical), Perception, medicine, Neurology & Neurosurgery, Behaviour Change and Well-being, business.industry, R-PACKAGE, 3112 Neurosciences, Pneumonia, Parosmia, COMPONENT, Smagssans, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Sensoriek en eetgedrag, chemistry, Lugtetab, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, 030217 neurology & neurosurgery, Lugtesans
Abstract: Correction: Chemical Senses, Volume 46, 2021, bjab050, https://doi.org/10.1093/chemse/bjab050 Published: 08 December 2021 Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change +/- 100) revealed a mean reduction of smell (-79.7 +/- 28.7, mean +/- standard deviation), taste (-69.0 +/- 32.6), and chemesthetic (-37.3 +/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis.The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.
Published: 2020

13. GOODS-ALMA 2.0: Source catalog, number counts, and prevailing compact sizes in 1.1 mm galaxies

Author: Gómez-Guijarro, C., Elbaz, D., Xiao, M., Béthermin, M., Franco, M., Magnelli, B., Daddi, E., Dickinson, M., Demarco, R., Inami, H., Rujopakarn, W., Magdis, G.E., Shu, X., Chary, R., Zhou, L., Alexander, D.M., Bournaud, F., Ciesla, L., Ferguson, H.C., Finkelstein, S.L., Finlez, C., Giavalisco, M., Iono, D., Juneau, S., Kartaltepe, J.S., Lagache, G., Le Floc'H, E., Leiton, R., Lin, L., Messias, H., Motohara, K., Mullaney, J., Nagar, N.M., Okumura, K., Pannella, M., Papovich, C., Pope, A., Sargent, M.T., Silverman, J.D., Treister, E., Wang, T., Le Floc’h, E., Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of Hertfordshire [Hatfield] (UH), NSF’s National Optical-Infrared Astronomy Research Laboratory (NOIRLab), Universidad de Concepción - University of Concepcion [Chile], Hiroshima University, Chulalongkorn University [Bangkok], Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Anhui Normal University, California Institute of Technology (CALTECH), Nanjing University (NJU), Durham University, Space Telescope Science Institute (STSci), University of Texas at Austin [Austin], University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS), National Astronomical Observatory of Japan (NAOJ), Rochester Institute of Technology, Département d'Astrophysique (ex SAP) (DAP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Academia Sinica, The University of Tokyo (UTokyo), University of Sheffield [Sheffield], Università degli studi di Trieste = University of Trieste, Texas A&M University System, University of Sussex, Pontificia Universidad Católica de Chile (UC), Univ New South Wales, MERLin Sch Chem Engn, Sydney, NSW 2052, Australia, and We thank G. Pöpping, C. del P. Lagos, and J. A.Zavala for providing the predicted number counts from their models plotted in Fig. 11. M.F. acknowledges the support from STFC (grant number ST/R000905/1). G.E.M. acknowledges the Villum Fonden research grant 13160 ‘Gas to stars, stars to dust: tracing star formation across cosmic time’ and the Cosmic Dawn Center of Excellence funded by the Danish National Research Foundation under the grant No. 140. H.I. acknowledges support from JSPS KAKENHI Grant Number JP19K23462 and JP21H01129. M.T.S. acknowledges support from a Scientific Exchanges visitor fellowship (IZSEZO_202357) from the Swiss National Science Foundation. This papermakes use of the following ALMA data: ADS/JAO.ALMA#2015.1.00543.S and ADS/JAO.ALMA#2017.1.00755.S. ALMA is a partnership of ESO (representing its member states), NSF (USA) and NINS (Japan), together with NRC (Canada), MOST and ASIAA (Taiwan), and KASI (Republic of Korea), in cooperation with the Republic of Chile. The Joint ALMA Observatory is operated by ESO, AUI/NRAO and NAOJ. We are grateful to the anonymous referee, whose comments have been very useful to improving our work
Subjects: submillimeter: galaxies, Cosmology and Nongalactic Astrophysics (astro-ph.CO), Stellar mass, structure [Galaxies], PHYSICAL-PROPERTIES, FOS: Physical sciences, Flux, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, star formation [Galaxies], 01 natural sciences, GMASS ULTRADEEP SPECTROSCOPY, high-redshift [Galaxies], galaxies [Submillimeter], galaxies: high-redshift, 0103 physical sciences, STAR-FORMING GALAXIES, Sensitivity (control systems), Continuum (set theory), DEEP FIELD-SOUTH, MAIN-SEQUENCE, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Effective radius, Physics, DEGREE EXTRAGALACTIC SURVEY, SUBMILLIMETER GALAXIES, 010308 nuclear & particles physics, photometry [Galaxies], Homogeneity (statistics), MASSIVE GALAXIES, Astronomy and Astrophysics, evolution [Galaxies], FAR-INFRARED PROPERTIES, Astrophysics - Astrophysics of Galaxies, Galaxy, Redshift, galaxies: photometry, LUMINOSITY FUNCTION, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), galaxies: star formation, galaxies: structure, Astrophysics::Earth and Planetary Astrophysics, galaxies: evolution, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Submillimeter/millimeter observations of dusty star-forming galaxies with the Atacama Large Millimeter/submillimeter Array (ALMA) have shown that dust continuum emission generally occurs in compact regions smaller than the stellar distribution. However, it remains to be understood how systematic these findings are. Studies often lack homogeneity in the sample selection, target discontinuous areas with inhomogeneous sensitivities, and suffer from modest $uv$ coverage coming from single array configurations. GOODS-ALMA is a 1.1mm galaxy survey over a continuous area of 72.42arcmin$^2$ at a homogeneous sensitivity. In this version 2.0, we present a new low resolution dataset and its combination with the previous high resolution dataset from the survey, improving the $uv$ coverage and sensitivity reaching an average of $��= 68.4��$Jy beam$^{-1}$. A total of 88 galaxies are detected in a blind search (compared to 35 in the high resolution dataset alone), 50% at $S/N_{peak} \geq 5$ and 50% at $3.5 \leq S/N_{peak} \leq 5$ aided by priors. Among them, 13 out of the 88 are optically dark or faint sources ($H$- or $K$-band dropouts). The sample dust continuum sizes at 1.1mm are generally compact, with a median effective radius of $R_{e} = 0"10 \pm 0"05$ (a physical size of $R_{e} = 0.73 \pm 0.29$kpc at the redshift of each source). Dust continuum sizes evolve with redshift and stellar mass resembling the trends of the stellar sizes measured at optical wavelengths, albeit a lower normalization compared to those of late-type galaxies. We conclude that for sources with flux densities $S_{1.1mm} > 1$mJy, compact dust continuum emission at 1.1mm prevails, and sizes as extended as typical star-forming stellar disks are rare. The $S_{1.1mm} < 1$mJy sources appear slightly more extended at 1.1mm, although they are still generally compact below the sizes of typical star-forming stellar disks., Accepted by A&A. 30 pages, 18 figures
Published: 2022

14. GOODS-ALMA 2.0:Starbursts in the main sequence reveal compact star formation regulating galaxy evolution prequenching

Author: C. Gómez-Guijarro, D. Elbaz, M. Xiao, V. I. Kokorev, G. E. Magdis, B. Magnelli, E. Daddi, F. Valentino, M. T. Sargent, M. Dickinson, M. Béthermin, M. Franco, A. Pope, B. S. Kalita, L. Ciesla, R. Demarco, H. Inami, W. Rujopakarn, X. Shu, T. Wang, L. Zhou, D. M. Alexander, F. Bournaud, R. Chary, H. C. Ferguson, S. L. Finkelstein, M. Giavalisco, D. Iono, S. Juneau, J. S. Kartaltepe, G. Lagache, E. Le Floc’h, R. Leiton, L. Leroy, L. Lin, K. Motohara, J. Mullaney, K. Okumura, M. Pannella, C. Papovich, E. Treister, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of Copenhagen = Københavns Universitet (UCPH), Danmarks Tekniske Universitet = Technical University of Denmark (DTU), University of Sussex, Community Science and Data Center, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), University of Hertfordshire [Hatfield] (UH), University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS), Universidad de Concepción - University of Concepcion [Chile], Hiroshima University, Chulalongkorn University [Bangkok], Anhui Normal University, Nanjing University (NJU), Durham University, California Institute of Technology (CALTECH), Space Telescope Science Institute (STSci), University of Texas at Austin [Austin], National Astronomical Observatory of Japan (NAOJ), Rochester Institute of Technology, Academia Sinica, The University of Tokyo (UTokyo), University of Sheffield [Sheffield], Università degli studi di Trieste = University of Trieste, Texas A&M University [College Station], and Pontificia Universidad Católica de Chile (UC)
Subjects: submillimeter: galaxies, SPECTROSCOPIC SURVEY, Cosmology and Nongalactic Astrophysics (astro-ph.CO), SIMILAR-TO 3, MASS-METALLICITY RELATION, INFRARED-EMISSION, structure [Galaxies], FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, star formation [Galaxies], star formation, high-redshift, high-redshift [Galaxies], galaxies [Submillimeter], galaxies: high-redshift, galaxies, evolution, DUST TEMPERATURES, Astrophysics::Solar and Stellar Astrophysics, submillimeter, structure, Astrophysics::Galaxy Astrophysics, FORMING GALAXIES, SUBMILLIMETER GALAXIES, galaxies: fundamental parameters, Astronomy and Astrophysics, evolution [Galaxies], Astrophysics - Astrophysics of Galaxies, ORIGINS DEEP SURVEY, MOLECULAR GAS FRACTIONS, Space and Planetary Science, galaxies: star formation, Astrophysics of Galaxies (astro-ph.GA), fundamental parameters [Galaxies], galaxies: structure, Astrophysics::Earth and Planetary Astrophysics, galaxies: evolution, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], fundamental parameters, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract: Compact star formation appears to be generally common in dusty star-forming galaxies (SFGs). However, its role in the framework set by the scaling relations in galaxy evolution remains to be understood. In this work we follow up on the galaxy sample from the GOODS-ALMA 2.0 survey, an ALMA blind survey at 1.1mm covering a continuous area of 72.42arcmin$^2$ using two array configurations. We derived physical properties, such as star formation rates, gas fractions, depletion timescales, and dust temperatures for the galaxy sample built from the survey. There exists a subset of galaxies that exhibit starburst-like short depletion timescales, but they are located within the scatter of the so-called main sequence of SFGs. These are dubbed starbursts in the main sequence and display the most compact star formation and they are characterized by the shortest depletion timescales, lowest gas fractions, and highest dust temperatures of the galaxy sample, compared to typical SFGs at the same stellar mass and redshift. They are also very massive, accounting for $\sim 60\%$ of the most massive galaxies in the sample ($\log (M_{\rm{*}}/M_{\odot}) > 11.0$). We find trends between the areas of the ongoing star formation regions and the derived physical properties for the sample, unveiling the role of compact star formation as a physical driver of these properties. Starbursts in the main sequence appear to be the extreme cases of these trends. We discuss possible scenarios of galaxy evolution to explain the results drawn from our galaxy sample. Our findings suggest that the star formation rate is sustained in SFGs by gas and star formation compression, keeping them within the main sequence even when their gas fractions are low and they are presumably on the way to quiescence., Accepted by A&A. 26 pages, 13 figures
Published: 2022

15. Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae

Author: Jean-Christophe Simon, Adam Pym, Joanna Mackisack, Alexander Hayward, Pablo Bielza, Kamel Charaabi, John Vontas, Hannah J. Burrack, Chris Bass, Ralf Nauen, Young-Nam Youn, Ilona Stepanyan, Ana Duarte, Fabrice Legeai, Gao Xiwu, Richard H. ffrench-Constant, Christoph T. Zimmer, Kumar Saurabh Singh, Bartlomiej J. Troczka, Guangwei Ren, Alex C.C. Wilson, Stéphanie Robin, Thomas C. Mathers, Christian C. Figueroa, Claudio C. Ramírez, Erick M. G. Cordeiro, Georg Jander, Martin S. Williamson, Ian Denholm, Emanuele Mazzoni, John T. Margaritopoulos, Paul A Umina, Nina V. Voronova, University of Exeter, Escola Superior de Agricultura 'Luiz de Queiroz' (ESALQ), Universidade de São Paulo (USP), John Innes Centre [Norwich], Institut de Génétique, Environnement et Protection des Plantes (IGEPP), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Scalable, Optimized and Parallel Algorithms for Genomics (GenScale), Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-GESTION DES DONNÉES ET DE LA CONNAISSANCE (IRISA-D7), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-CentraleSupélec-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Bretagne Sud (UBS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Technical University of Cartagena (UPTC), North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC), Institut Supérieur de Biotechnologie de Sidi Thabet (ISBST), Université de la Manouba [Tunisie] (UMA), University of Hertfordshire [Hatfield] (UH), Universidad de Talca, Boyce Thompson Institute [Ithaca], Hellenic Agricultural Organization Demeter (HAO Demeter), Università cattolica del Sacro Cuore [Milano] (Unicatt), Bayer Pharma AG [Berlin], Chinese Academy of Agricultural Sciences (CAAS), National Academy of Sciences of the Republic of Armenia [Yerevan] (NAS RA), School of BioSciences [Melbourne], Faculty of Science [Melbourne], University of Melbourne-University of Melbourne, Belarusian State University, Foundation for Research and Technology - Hellas (FORTH), Agricultural University of Athens, Rothamsted Research, University of Miami [Coral Gables], China Agricultural University (CAU), Chungnam National University (CNU), This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 646625), and the Biotechnology and Biological Sciences Research Council (BBSRC) (grant number: BB/S006060/1). Illumina sequencing of clone 126 was funded by Defense Advanced Research Projects Agency (DARPA) agreement HR0011-17-2-0053 to G.J. A.C.C.W. was supported by National Science Foundation Award IOS-1354154. A.H. is supported by a BBSRC David Phillips Fellowship (BB/N020146/1), and T.C.M. by a BBSRC Future Leaders Fellowship (BB/R01227X/1)., European Project: 646625,H2020,ERC-2014-CoG,P450RESIST(2016), Universidade de São Paulo = University of São Paulo (USP), Biotechnology and Biological Sciences Research Council (BBSRC), Université de Rennes (UR)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Universidad Politécnica de Cartagena / Technical University of Cartagena (UPCT), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Rennes 1 (UR1), and Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique)
Subjects: Insecticides, [SDV]Life Sciences [q-bio], Genome, Insect, Myzus persicae, Medicine (miscellaneous), Sequence assembly, Insect, Insecticide Resistance, RESISTÊNCIA GENÉTICA ANIMAL, 0302 clinical medicine, Host races association, Biology (General), Pyrethroid insecticides, Phylogeny, media_common, 0303 health sciences, Aphid, biology, Geography, Sodium channel, food and beverages, Genomics, Plants, Peach-potato aphid, Settore AGR/11 - ENTOMOLOGIA GENERALE E APPLICATA, General Agricultural and Biological Sciences, Agricultural genetics, QH301-705.5, media_common.quotation_subject, Locus (genetics), Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, Evolutionary genetics, Host-Parasite Interactions, Evolution, Molecular, Hemiptera, 03 medical and health sciences, Sequence Homology, Nucleic Acid, Animals, Genetic variation, genome, 030304 developmental biology, Resistance (ecology), Base Sequence, Genetic Variation, 15. Life on land, biology.organism_classification, Evolutionary biology, Aphids, Mutation, Adaptation, 030217 neurology & neurosurgery, Diversity (politics)
Abstract: The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host–plant associations, uncovering the widespread co‐option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites., Singh, Bass and colleagues generate new genomic resources for the aphid crop pest, Myzus persicae, comprising a chromosome-scale genome assembly and resequenced genomes of >100 globally sampled clonal lines. Using this dataset, they uncover both mechanisms underpinning the evolution of insecticide resistance and ecological factors that influence its emergence and spread.
Published: 2021

16. Dispersion of Tracers in the Stable Atmosphere of a Valley Opening onto a Plain

Author: Gabriele Arduini, Chantal Staquet, Charles Chemel, Julian Quimbayo-Duarte, Laboratoire des Écoulements Géophysiques et Industriels [Grenoble] (LEGI ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University of Hertfordshire [Hatfield] (UH), and European Centre for Medium-Range Weather Forecasts (ECMWF)
Subjects: Atmospheric Science, Jet (fluid), Buoyancy, 010504 meteorology & atmospheric sciences, Flow (psychology), Flux, engineering.material, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, 01 natural sciences, Physics::Fluid Dynamics, Atmosphere, Amplitude, 13. Climate action, TRACER, engineering, [PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph], Dispersion (water waves), Geomorphology, ComputingMilieux_MISCELLANEOUS, Physics::Atmospheric and Oceanic Physics, Geology, 0105 earth and related environmental sciences
Abstract: We quantify the impact of a valley-wind system on the transport of passive tracers in the stably-stratified atmosphere of a valley dynamically decoupled from the atmosphere above. The simple configuration of an idealized Alpine-type valley opening onto a plain is considered, for two values of the initial buoyancy frequency and of the valley steepness. The valley-wind system consists of thermally-driven downslope flows that induce a pressure difference between the valley interior and the plain, thereby triggering a down-valley flow. A steady-state regime is eventually reached, at the beginning of which passive tracers are emitted at the valley floor and at different heights above it. The tracer emitted at the valley floor is fully mixed below the height of the maximum speed of the down-valley flow, which behaves like a jet, and remains decoupled from the tracers emitted above. The down-valley flow increases linearly in the along-valley direction y so that, from the conservation of tracer flux, the tracer concentration decays as 1 / y. A simple theoretical model is proposed to fully account for the down-valley flow and tracer behaviour. The tracer concentration emitted at the valley floor also displays marked oscillations, induced by internal gravity waves radiated via a hydraulic-jump process when the downslope flow reaches the valley floor. The amplitude of the oscillations can be as high as 50% of their mean value, implying that averaged values in an urbanized valley may disguise high instantaneous—and potentially harmful-values.
Published: 2019

17. Erratum to: Using a generic definition of cachexia to understand clinical characteristics and mortality in patients with kidney disease receiving haemodialysis: a longitudinal (pilot) study

Author: Mckeaveney, C., Slee, A., Adamson, G., Davenport, A., Farrington, K., Fouque, D., Kalanter-Zadeh, K., Mallett, J., Maxwell, A. P., Mullan, R., Noble, H., O'Donoghue, D., Porter, S., Seres, D. S., Shields, J., Witham, M., Reid, J., University College of London [London] (UCL), University of Ulster, School of Metallurgy and Materials, University of Birmingham [Birmingham], University of Hertfordshire [Hatfield] (UH), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of California [Irvine] (UCI), University of California, Royal Victoria Hospital [Belfast, UK], Queen's University [Belfast] (QUB), Belfast City Hospital, Antrim Area Hospital - Northern Health and Social Care Trust [Antrim, Northern Ireland] (AAH-NHSCT), University of Manchester [Manchester], Bournemouth University [Poole] (BU), New York Presbyterian Hospital, Newcastle University [Newcastle], University of California [Irvine] (UC Irvine), University of California (UC), and CarMeN, laboratoire
Subjects: [SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2021

18. The relationship between Europeanisation and policy styles: a study of agricultural and public health policymaking in three EU Member States

Author: Kelly Parsons, David Barling, Jeroen J. L. Candel, Salma Loudiyi, Public administration and policy group, Wageningen University and Research [Wageningen] (WUR), University of Hertfordshire [Hatfield] (UH), Territoires (Territoires), AgroParisTech-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), and AgroParisTech-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA)
Subjects: medicine.medical_specialty, Public Administration, Sociology and Political Science, WASS, policy regimes, 050601 international relations, food policy, [SHS.DROIT]Humanities and Social Sciences/Law, Europeanisation, Political science, 050602 political science & public administration, medicine, Agricultural policy, agricultural policy, Adaptation pressure, policy styles, business.industry, Public health, Member states, Public Administration and Policy, 05 social sciences, language.human_language, 0506 political science, Agriculture, Political economy, Food policy, language, Bestuurskunde, business
Abstract: International audience; The role of policy styles in policymaking has attracted renewed scholarly interest in recent years. One of the central debates in this literature revolves around the question of how to reconcile archetype national policy styles with considerable differences in modus operandi across policy sectors. A sector-specific feature that is considered a key determinant of the manifestation of archetype national policy styles in the European Union is the degree of Europeanisation of policy sectors. This paper picks up this suggestion by addressing the question of whether and how Europeanisation affects the degree to which features of an archetype national policy style are manifest within a sector. We address this question by exploring sectoral policy styles in agricultural and food-related public health policymaking across three EU Member States: The Netherlands, the United Kingdom (England), and France. Our findings suggest that the degree of Europeanisation of a policy sectordoesprove an important condition that helps to understand the relationship between national and sectoral policy styles. More specifically, Europeanisation has the strongest effect when sectors face a higher adaptation pressure, i.e., when there is a larger misfit between sectoral regimes and EU-induced institutional demands. We suggest various promising avenues of future research on this relationship.
Published: 2021

19. Digital Twins of an Organization for Enterprise Modeling

Author: Sabrina Javaid, Heiko Maus, Uwe V. Riss, Christian Jilek, University of Applied Sciences of Eastern Switzerland (FHO), University of Hertfordshire [Hatfield] (UH), Deutsches Forschungszentrum für Künstliche Intelligenz GmbH = German Research Center for Artificial Intelligence (DFKI), Department of Computer Science [Kaiserslautern], Technische Universität Kaiserslautern (TU Kaiserslautern), Jānis Grabis, Dominik Bork, TC 8, and WG 8.1
Subjects: 0209 industrial biotechnology, Process management, Exploit, Knowledge representation and reasoning, business.industry, Business process, Computer science, Context (language use), 02 engineering and technology, Digital Twin of an Organization, Enterprise modelling, Process context, 020901 industrial engineering & automation, Context spaces, 0202 electrical engineering, electronic engineering, information engineering, Information system, 020201 artificial intelligence & image processing, Organizational structure, [INFO]Computer Science [cs], business, Enterprise modeling, Agile software development
Abstract: Part 2:Enterprise Modeling and Enterprise Architecture; International audience; Today’s dynamic business environment requires enterprises to be agile in order to remain competitive. Competition also impacts enterprise modeling (EM) aiming at the systematic development of the enterprise’s business processes, organizational structures, and information systems. Although EM is a mature discipline, organizations still do not exploit the full potential of EM. We suggest, the concept of a Digital Twin of an Organization (DTO) provides a means of digitalization to introduce more agility. A DTO draws upon graph-based, machine readable knowledge representation of enterprise models. In order to run through various scenarios in real time, the DTO approach makes use of Context Spaces that provide the required information semantically structured, which improves the comprehensibility and applicability of the used models. The DTO combines EM with operational reality and, thus, increases the agility of the enterprise.
Published: 2020

20. Using a generic definition of cachexia in patients with kidney disease receiving haemodialysis: a longitudinal (pilot) study

Author: Helen Noble, Adrian Slee, Clare McKeaveney, John Mallett, Kamyar Kalantar-Zadeh, Andrew Davenport, Joanne Shields, Donal O'Donoghue, Ken Farrington, Samuel Porter, Denis Fouque, Alexander P. Maxwell, David S. Seres, Miles D. Witham, Joanne Reid, Gary Adamson, Robert Mullan, CarMeN, laboratoire, University College of London [London] (UCL), University of Ulster, University of Hertfordshire [Hatfield] (UH), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of California [Irvine] (UC Irvine), University of California (UC), Royal Victoria Hospital [Belfast, UK], Queen's University [Belfast] (QUB), Belfast City Hospital, Antrim Area Hospital - Northern Health and Social Care Trust [Antrim, Northern Ireland] (AAH-NHSCT), University of Manchester [Manchester], Bournemouth University [Poole] (BU), New York Presbyterian Hospital, Newcastle University [Newcastle], Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), University of California [Irvine] (UCI), and University of California
Subjects: Male, medicine.medical_specialty, Longitudinal study, Cachexia, phenotype, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030232 urology & nephrology, cachexia, 03 medical and health sciences, 0302 clinical medicine, Weight loss, Renal Dialysis, Internal medicine, medicine, Humans, definition, 030212 general & internal medicine, Longitudinal Studies, Dialysis, Aged, 2. Zero hunger, Aged, 80 and over, Transplantation, Hand Strength, business.industry, Repeated measures design, Longitudinal analysis, longitudinal analysis, Definition, Middle Aged, medicine.disease, 3. Good health, haemodialysis, [SDV] Life Sciences [q-bio], Haemodialysis, Phenotype, Nephrology, Female, Kidney Diseases, Hemodialysis, medicine.symptom, business, Body mass index, Kidney disease
Abstract: Background Research indicates that cachexia is common among persons with chronic illnesses and is associated with increased morbidity and mortality. However, there continues to be an absence of a uniformed disease-specific definition for cachexia in chronic kidney disease (CKD) patient populations. Objective The primary objective was to identify cachexia in patients receiving haemodialysis (HD) using a generic definition and then follow up on these patients for 12 months. Method This was a longitudinal study of adult chronic HD patients attending two hospital HD units in the UK. Multiple measures relevant to cachexia, including body mass index (BMI), muscle mass [mid-upper arm muscle circumference (MUAMC)], handgrip strength (HGS), fatigue [Functional Assessment of Chronic Illness Therapy (FACIT)], appetite [Functional Assessment of Anorexia/Cachexia Therapy (FAACT)] and biomarkers [C-reactive protein (CRP), serum albumin, haemoglobin and erythropoietin resistance index (ERI)] were recorded. Baseline analysis included group differences analysed using an independent t-test, dichotomized values using the χ2 test and prevalence were reported using the Statistical Package for the Social Sciences 24 (IBM, Armonk, NY, USA). Longitudinal analysis was conducted using repeated measures analysis. Results A total of 106 patients (30 females and 76 males) were recruited with a mean age of 67.6 years [standard deviation (SD) 13.18] and dialysis vintage of 4.92 years (SD 6.12). At baseline, 17 patients were identified as cachectic, having had reported weight loss (e.g. >5% for >6 months) or BMI Conclusion Globally, cachexia is a severe but frequently underrecognized problem. This is the first study to apply the defined characteristics of cachexia to a representative sample of patients receiving HD. Further, more extensive studies are required to establish a phenotype of cachexia in advanced CKD.
Published: 2020

21. The influence of entrepreneurial personality on franchisee performance: A cross-cultural analysis

Author: Begoña López-Fernández, Rozenn Perrigot, Olufunmilola (Lola) Dada, Anna Watson, University of Hertfordshire [Hatfield] (UH), Lancaster University, University of Oviedo, Centre de recherche en économie et management (CREM), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), ECO2017-85704-R, Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Normandie Université (NU)-Normandie Université (NU)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Entrepreneurial orientation, media_common.quotation_subject, 05 social sciences, entrepreneurial orientation, franchisee performance, innovative personality, locus of control, proactive personality, entrepreneurial orientation, innovative personality, Locus of control, proactive personality, 0502 economics and business, Cross-cultural, Personality, [SHS.GESTION]Humanities and Social Sciences/Business administration, 050211 marketing, locus of control, Business and International Management, Psychology, Social psychology, 050203 business & management, media_common, franchisee performance
Abstract: International audience; Through a survey-based study of 761 franchisees from four countries, the United States, the United Kingdom, France and Spain – this research examines how a franchisee’s entrepreneurial personality traits affects the financial and relational performance of franchise units. While there is consensus that franchisee characteristics are important for successful franchise networks, there is a long-standing debate within the franchise literature as to the status, and indeed desirability, of franchisees as entrepreneurs. First, we consider how the personality traits of proactivity, innovativeness and locus of control influence the manifestation of entrepreneurial behaviours within the franchise unit, and both the direct and indirect relationships with unit performance. Second, we explore these relationships in two contexts, one associated with high entrepreneurial values (the United States and the United Kingdom) and another with low entrepreneurial values (France and Spain) to determine if the results are consistent across cultures which value entrepreneurship differently. The results suggest that franchisee performance, in terms of both financial performance and relationship quality, are indirectly enhanced by a proactive disposition, mediated by entrepreneurial behaviours. A direct positive relationship was found between locus of control and performance outcomes, but interestingly, franchisees with more innovative personalities performed less well financially. The relationships between franchisee personality, entrepreneurial orientation (EO) and performance were found to be largely consistent across the two cultural groups. © The Author(s) 2020.
Published: 2020

22. GOODS-ALMA: Using IRAC and VLA to probe fainter millimeter galaxies

Author: Neil M. Nagar, M. Franco, Maurilio Pannella, C. Gómez-Guijarro, Laure Ciesla, E. Daddi, Casey Papovich, Stéphanie Juneau, Koryo Okumura, Henry C. Ferguson, Matthieu Béthermin, David Elbaz, Lihwai Lin, Mark Dickinson, Frédéric Bournaud, Mauro Giavalisco, Tao Wang, John D. Silverman, Steven L. Finkelstein, Hanae Inami, L. Zhou, Xinwen Shu, R. T. Coogan, Benjamin Magnelli, Kentaro Motohara, Daisuke Iono, Guilaine Lagache, Georgios E. Magdis, Wiphu Rujopakarn, Alexandra Pope, Corentin Schreiber, Mengyuan Xiao, David M. Alexander, Ricardo Demarco, James Mullaney, Ranga-Ram Chary, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), University of Hertfordshire [Hatfield] (UH), Nanjing University (NJU), Argelander Institute for Astronomy (AlfA), Rheinische Friedrich-Wilhelms-Universität Bonn, University of Oxford, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), National Optical Astronomy Observatory (NOAO), Universidad de Conception, Niels Bohr Institute [Copenhagen] (NBI), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), National Observatory of Athens (NOA), Durham University, University of Sheffield [Sheffield], Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Hiroshima University, Anhui Normal University, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Infrared Processing and Analysis Center (IPAC), California Institute of Technology (CALTECH), Max Planck Institute for Extraterrestrial Physics (MPE), Max-Planck-Gesellschaft, Space Telescope Science Institute (STSci), University of Texas at Austin [Austin], University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS), National Astronomical Observatory of Japan (NAOJ), Graduate University for Advanced Studies [Hayama] (SOKENDAI), Università degli studi di Trieste = University of Trieste, Ludwig-Maximilians-Universität München (LMU), Kavli Institute for the Physics and Mathematics of the Universe [Tokyo] (Kavli IPMU), The University of Tokyo Institutes for Advanced Study (UTIAS), The University of Tokyo (UTokyo)-The University of Tokyo (UTokyo), Chulalongkorn University [Bangkok], National Astronomical Research Institute of Thailand (NARIT), This work was supported by the Programme National Cosmology et Galaxies (PNCG) of CNRS/INSU with INP and IN2P3, co-funded by CEA and CNES., European Project: 648179,H2020,ERC-2014-CoG,ConTExt(2015), European Project: 716762,ClustersXCosmo, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), University of Oxford [Oxford], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), and University of Trieste
Subjects: submillimeter: galaxies, SPECTROSCOPIC SURVEY, TELESCOPE, IMAGER, SCUBA, FOS: Physical sciences, CAMERA, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, star formation [Galaxies], 01 natural sciences, high-redshift [Galaxies], galaxies [Submillimeter], galaxies: high-redshift, 0103 physical sciences, STAR-FORMING GALAXIES, Astrophysics::Solar and Stellar Astrophysics, FIELD, 010303 astronomy & astrophysics, License, Astrophysics::Galaxy Astrophysics, Physics, 010308 nuclear & particles physics, photometry [Galaxies], Astronomy and Astrophysics, galaxies: fundamental parameters, Creative commons, evolution [Galaxies], Astrophysics - Astrophysics of Galaxies, Galaxy, SPITZER, galaxies: photometry, ORIGINS DEEP SURVEY, STELLAR, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), galaxies: star formation, fundamental parameters [Galaxies], Millimeter, Astrophysics::Earth and Planetary Astrophysics, galaxies: evolution, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: In this paper, we extend the source detection in the GOODS-ALMA field (69 arcmin$^2$, rms sensitivity $\sigma$ $\simeq$ 0.18 mJy.beam$^{-1}$), to deeper levels than presented in Franco et al. (2018). Using positional information at 3.6 and 4.5 $\mu$m (from Spitzer-IRAC), we explore the presence of galaxies detected at 1.1 mm with ALMA below our original blind detection limit of 4.8-$\sigma$ at which the number of spurious sources starts to dominate over that of real sources. In this Supplementary Catalog, we find a total of 16 galaxies, including 2 galaxies with no counterpart in HST images (also known as optically-dark galaxies) down to a 5$\sigma$ limiting depth of H = 28.2 AB (HST/WFC3 F160W). This brings the total sample of GOODS-ALMA 1.1 mm sources to 35 galaxies. Galaxies in the new sample cover a wider dynamic range in redshift ($z$ = 0.65 - 4.73), are on average twice as large (1.3 vs 0.65 kpc) and and have lower stellar mass (M$_{\star}^{\rm SC}$ = 7.6$\times$10$^{10}$M$_\odot$ vs M$_{\star}^{\rm MC}$ = 1.2$\times$10$^{11}$M$_\odot$). Although exhibiting larger physical sizes, these galaxies have still far-infrared sizes significantly more compact than inferred from their optical emission. We show that the astrometry of the HST image does not only suffer from a global astrometric shift, as already discussed in previous papers, but also from local shifts. These distortions were artificially introduced in the process of building the mosaic of the GOODS-South HST image. By comparing the positions of almost 400 galaxies detected by HST, Pan-STARRS and ALMA, we create a distortion map which can be used to correct for these astrometric issues., Comment: 18 pages, 13 figures. Accepted for publication in A&A
Published: 2020

23. Acceptability in the Older Population: The Importance of an Appropriate Tablet Size

Author: Yogini Jani, Patrick Leglise, Matthieu Piccoli, Vincent Boudy, Hugues Michelon, Aurélie Le Fur, Thibault Vallet, Mine Orlu, Fabrice Ruiz, Sandra Laribe-Caget, Fang Liu, ClinSearch, Hôpital Sainte Perine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), UCL School of Pharmacy, University College London Hospitals (UCLH), Hôpitaux Universitaires Henri-Mondor, Hôpital Rothschild [AP-HP], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], University of Hertfordshire [Hatfield] (UH), Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1022)), Institut de Chimie du CNRS (INC)-Université de Paris (UP)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), ORANGE, Colette, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)
Subjects: medicine.medical_specialty, medicine, Care homes, Pharmaceutical Science, lcsh:RS1-441, formulation, 02 engineering and technology, CAST (ClinSearch acceptability score test), [SDV.SP.PG] Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology, DYSPHAGIA, 030226 pharmacology & pharmacy, size, Article, Older population, lcsh:Pharmacy and materia medica, 03 medical and health sciences, 0302 clinical medicine, Older patients, acceptability, otorhinolaryngologic diseases, SODF, business.industry, Swallowing Disorders, ADULTS, 021001 nanoscience & nanotechnology, Dysphagia, older population, 3. Good health, [SDV.SP.PG]Life Sciences [q-bio]/Pharmaceutical sciences/Galenic pharmacology, MEDICINES, Physical therapy, medicine.symptom, 0210 nano-technology, Older people, business
Abstract: Presenting many advantages, solid oral dosage forms (SODFs) are widely manufactured and frequently prescribed in older populations regardless of the specific characteristics of patients. Commonly, patients with dysphagia (swallowing disorders) experience difficulties taking SODFs, which may lead to non-adherence or misuse. SODF characteristics (e.g., size, shape, thickness) are likely to influence swallowability. Herein, we used the acceptability reference framework (the ClinSearch acceptability score test (CAST))&mdash, a 3D-map juxtaposing two acceptability profiles&mdash, to investigate the impact of tablet size on acceptability. We collected 938 observer reports on the tablet intake by patients &ge, 65 years in hospitals or care homes. As we might expect, tablets could be classified as accepted in older patients without dysphagia (n = 790), while not in those with swallowing disorders (n = 146). However, reducing the tablet size had a significant impact on acceptability in this subpopulation: tablets &lt, 6.5 mm appeared to be accepted by patients with swallowing disorders. Among the 309 distinct tablets assessed in this study, ranging in size from 4.7 to 21.5 mm, 83% are &ge, 6.5 mm and consequently may be poorly accepted by institutionalized older people and older inpatients suffering from dysphagia. This underlines the need to develop and prescribe medicines with the best adapted characteristics to reach an optimal acceptability in targeted users.
Published: 2020

24. The impact of unresolved magnetic spots on high precision radial velocity measurements

Author: Julien Morin, Pascal Petit, Maksym Lisogorskyi, Ansgar Reiners, Matthew W. Mengel, S. Boro Saikia, Sandra V. Jeffers, Aline A. Vidotto, Hugh R. A. Jones, University of Hertfordshire [Hatfield] (UH), University of Vienna [Vienna], Institut für Astrophysik [Göttingen], Georg-August-University [Göttingen], Laboratoire Univers et Particules de Montpellier (LUPM), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), University of Southern Queensland (USQ), Trinity College Dublin, Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], FOS: Physical sciences, Astrophysics, 01 natural sciences, symbols.namesake, Planet, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), Earth and Planetary Astrophysics (astro-ph.EP), Physics, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], 010308 nuclear & particles physics, Starspot, Astronomy and Astrophysics, Exoplanet, Magnetic field, Radial velocity, Stars, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, symbols, Astrophysics::Earth and Planetary Astrophysics, Doppler effect, Noise (radio), Astrophysics - Earth and Planetary Astrophysics
Abstract: The Doppler method of exoplanet detection has been extremely successful, but suffers from contaminating noise from stellar activity. In this work a model of a rotating star with a magnetic field based on the geometry of the K2 star Epsilon Eridani is presented and used to estimate its effect on simulated radial velocity measurements. A number of different distributions of unresolved magnetic spots were simulated on top of the observed large-scale magnetic maps obtained from eight years of spectropolarimetric observations. The radial velocity signals due to the magnetic spots have amplitudes of up to 10 m s$^{-1}$, high enough to prevent the detection of planets under 20 Earth masses in temperate zones of solar type stars. We show that the radial velocity depends heavily on spot distribution. Our results emphasize that understanding stellar magnetic activity and spot distribution is crucial for detection of Earth analogues., Main text: 7 pages, 3 figures. Appendix: 6 pages, 6 figures. Author name typo corrected. Accepted for publication in MNRAS
Published: 2020

25. Visualizing the invisible: class excursions to ignite children’s enthusiasm for microbes

Author: Esther Garcia Cela, Seth R. Bordenstein, Sharon Sivinski, Max M. Häggblom, Saskia Bindschedler, Pilar Junier, Fengping Wang, Rup Lal, Bonnie K. Baxter, Charles S. Cockell, Brajesh K. Singh, John E. Hallsworth, Nicole S. Webster, Terry J. McGenity, Carol Verheecke-Vaessen, Olga C. Nunes, Nancy P. Keller, Eddy J. Smid, Lisa Y. Stein, Paola Scavone, Corinne Whitby, Lone Gram, Amare Gessesse, Cindy Morris, Max Chavarría, Søren Molin, Cédric Lood, Kenneth N. Timmis, Antoine Danchin, André Antunes, Shuang Jiang Liu, University of Essex, Botswana International University of Science & Technology (BIUST), Queen's University [Belfast] (QUB), University of Hertfordshire [Hatfield] (UH), Cranfield University, Shanghai Jiao Tong University [Shanghai], Universidad de Costa Rica (UCR), Centro Nacional de Innovaciones Biotecnologicas (Cenibiot), National Center of High Technology (CeNAT-CONARE), Rutgers University [Newark], Rutgers University System (Rutgers), Technical University of Denmark [Lyngby] (DTU), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Wageningen University and Research [Wageningen] (WUR), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), SUPA School of Physics and Astronomy [Edinburgh], University of Edinburgh, Chinese Academy of Sciences [Beijing] (CAS), University of Wisconsin-Madison, University of Alberta, Vanderbilt University [Nashville], The Energy and Resources Institute (TERI), Universidade do Porto, Western Sydney University, Australian Institute of Marine Science (AIMS), University of Queensland [Brisbane], Unité de Pathologie Végétale (PV), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute of Biology of the University of Neuchâtel, Université de Neuchâtel (UNINE), Macau University of Science and Technology (MUST), Westminster College, Instituto de Investigaciones Biológicas Clemente Estable [Montevideo] (IIBCE), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Science and Technology Facilities Council. Grant Number: ST/S001425/1, Natural Environment Research Council. Grant Number: NE/S005560/1, Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Universidade do Porto = University of Porto, and DECOGNET, VERONIQUE
Subjects: Adult, Value (ethics), media_common.quotation_subject, [SHS.EDU]Humanities and Social Sciences/Education, [SHS.EDU] Humanities and Social Sciences/Education, education, Bioengineering, Applied Microbiology and Biotechnology, Biochemistry, Levensmiddelenmicrobiologie, Literacy, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Humans, Prealbumin, Life Science, Sociology, microbiologie, Child, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, Children, Curriculum, VLAG, 030304 developmental biology, media_common, sensibilisation, Benzoxazoles, 0303 health sciences, Enthusiasm, Class excursions, 030306 microbiology, business.industry, Flexibility (personality), Amyloidosis, Public relations, Outreach, Microbes, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Action (philosophy), Preparedness, Food Microbiology, business, TP248.13-248.65, Biotechnology
Abstract: We have recently argued that, because microbes have pervasive – often vital – influences on our lives, and that therefore their roles must be taken into account in many of the decisions we face, society must become microbiology‐literate, through the introduction of relevant microbiology topics in school curricula (Timmis et al. 2019. Environ Microbiol 21: 1513‐1528). The current coronavirus pandemic is a stark example of why microbiology literacy is such a crucial enabler of informed policy decisions, particularly those involving preparedness of public‐health systems for disease outbreaks and pandemics. However, a significant barrier to attaining widespread appreciation of microbial contributions to our well‐being and that of the planet is the fact that microbes are seldom visible: most people are only peripherally aware of them, except when they fall ill with an infection. And it is disease, rather than all of the positive activities mediated by microbes, that colours public perception of ‘germs’ and endows them with their poor image. It is imperative to render microbes visible, to give them life and form for children (and adults), and to counter prevalent misconceptions, through exposure to imagination‐capturing images of microbes and examples of their beneficial outputs, accompanied by a balanced narrative. This will engender automatic mental associations between everyday information inputs, as well as visual, olfactory and tactile experiences, on the one hand, and the responsible microbes/microbial communities, on the other hand. Such associations, in turn, will promote awareness of microbes and of the many positive and vital consequences of their actions, and facilitate and encourage incorporation of such consequences into relevant decision‐making processes. While teaching microbiology topics in primary and secondary school is key to this objective, a strategic programme to expose children directly and personally to natural and managed microbial processes, and the results of their actions, through carefully planned class excursions to local venues, can be instrumental in bringing microbes to life for children and, collaterally, their families. In order to encourage the embedding of microbiology‐centric class excursions in current curricula, we suggest and illustrate here some possibilities relating to the topics of food (a favourite pre‐occupation of most children), agriculture (together with horticulture and aquaculture), health and medicine, the environment and biotechnology. And, although not all of the microbially relevant infrastructure will be within reach of schools, there is usually access to a market, local food store, wastewater treatment plant, farm, surface water body, etc., all of which can provide opportunities to explore microbiology in action. If children sometimes consider the present to be mundane, even boring, they are usually excited with both the past and the future so, where possible, visits to local museums (the past) and research institutions advancing knowledge frontiers (the future) are strongly recommended, as is a tapping into the natural enthusiasm of local researchers to leverage the educational value of excursions and virtual excursions. Children are also fascinated by the unknown, so, paradoxically, the invisibility of microbes makes them especially fascinating objects for visualization and exploration. In outlining some of the options for microbiology excursions, providing suggestions for discussion topics and considering their educational value, we strive to extend the vistas of current class excursions and to: (i) inspire teachers and school managers to incorporate more microbiology excursions into curricula; (ii) encourage microbiologists to support school excursions and generally get involved in bringing microbes to life for children; (iii) urge leaders of organizations (biopharma, food industries, universities, etc.) to give school outreach activities a more prominent place in their mission portfolios, and (iv) convey to policymakers the benefits of providing schools with funds, materials and flexibility for educational endeavours beyond the classroom UK Research and Innovation/[ST/S001425/1]/UKRI/Reino Unido Functionality of Urban Soils/[NE/S005560/1]/FUSED/Reino Unido UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA)
Published: 2020
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26. High-resolution, 3D radiative transfer modelling

Author: A. Nersesian, Suzanne C. Madden, Anthony P. Jones, Jonathan Ivor Davies, Emmanuel M. Xilouris, S. Verstocken, Frédéric Galliano, Sébastien Viaene, Aleksandr V. Mosenkov, Simone Bianchi, Ana Trčka, Christopher J. R. Clark, Wouter Dobbels, Ilse De Looze, Maarten Baes, Viviana Casasola, Pieter De Vis, Sterrenkundig Observatorium, Universiteit Gent, National Technical University of Athens [Athens] (NTUA), National Observatory of Athens (NOA), University of Hertfordshire [Hatfield] (UH), INAF - Osservatorio Astrofisico di Arcetri (OAA), Istituto Nazionale di Astrofisica (INAF), Istituto di Radioastronomia [Bologna] (IRA), Space Telescope Science Institute (STSci), Cardiff University, University College of London [London] (UCL), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), The Central Astronomical Observatory of the Russian Academy of Sciences [Pulkovo], Russian Academy of Sciences [Moscow] (RAS), St Petersburg State University (SPbU), European Project: 606847,EC:FP7:SPA,FP7-SPACE-2013-1,DUSTPEDIA(2014), Universiteit Gent = Ghent University (UGENT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES)
Subjects: M 81, Stellar population, H-ALPHA, Extinction (astronomy), FOS: Physical sciences, FAR-INFRARED EMISSION, galaxies: individual: M 81, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, STAR-FORMATION, Atmospheric radiative transfer codes, 0103 physical sciences, galaxies, Radiative transfer, Astrophysics::Solar and Stellar Astrophysics, NEARBY GALAXIES, individual, EDGE-ON GALAXIES, 010303 astronomy & astrophysics, ISM, Astrophysics::Galaxy Astrophysics, Cosmic dust, Physics, infrared: ISM, Spiral galaxy, 010308 nuclear & particles physics, Star formation, extinction, Astronomy and Astrophysics, TRANSFER CODE, Astrophysics - Astrophysics of Galaxies, DISK-DOMINATED GALAXIES, Galaxy, SPECTRAL ENERGY-DISTRIBUTION, Physics and Astronomy, Space and Planetary Science, radiative transfer, Astrophysics of Galaxies (astro-ph.GA), infrared, Astrophysics::Earth and Planetary Astrophysics, dust, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], STELLAR POPULATION, INTERSTELLAR DUST, galaxies: ISM
Abstract: Interstellar dust absorbs stellar light very efficiently and thus shapes the energetic output of galaxies. Studying the impact of different stellar populations on the dust heating remains hard because it requires decoupling the relative geometry of stars and dust, and involves complex processes as scattering and non-local dust heating. We aim to constrain the relative distribution of dust and stellar populations in the spiral galaxy M81 and create a realistic model of the radiation field that describes the observations. Investigating the dust-starlight interaction on local scales, we want to quantify the contribution of young and old stellar populations to the dust heating. We aim to standardise the setup and model selection of such inverse radiative transfer simulations so this can be used for comparable modelling of other nearby galaxies. We present a semi-automated radiative transfer modelling pipeline that implements the necessary steps such as the geometric model construction and the normalisation of the components through an optimisation routine. We use the Monte Carlo radiative transfer code SKIRT to calculate a self-consistent, panchromatic model of the interstellar radiation field. By looking at different stellar populations independently, we can quantify to what extent different stellar age populations contribute to the dust heating. Our method takes into account the effects of non-local heating. We obtain a realistic 3D radiative transfer model of the face-on galaxy M81. We find that only 50.2\% of the dust heating can be attributed to young stellar populations. We confirm a tight correlation between the specific star formation rate and the heating fraction by young stellar populations, both in sky projection and in 3D, also found for radiative transfer models of M31 and M51. We conclude that... (abridged), 23 pages, 16 figures, accepted for publication in A&A
Published: 2020

27. Characterization of Nano-Mechanical, Surface and Thermal Properties of Hemp Fiber-Reinforced Polycaprolactone (HF/PCL) Biocomposites

Author: Jurgita Zekonyte, Hom Nath Dhakal, Johnny Beaugrand, Sikiru Oluwarotimi Ismail, Zhongyi Zhang, University of Portsmouth, University of Hertfordshire [Hatfield] (UH), Fractionnement des AgroRessources et Environnement (FARE), and Université de Reims Champagne-Ardenne (URCA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Thermogravimetric analysis, Materials science, nanoindentation, 02 engineering and technology, contact angle measurements, 010402 general chemistry, 01 natural sciences, lcsh:Technology, thermal stability, Contact angle, lcsh:Chemistry, chemistry.chemical_compound, Crystallinity, Differential scanning calorimetry, polycaprolactone, General Materials Science, Thermal stability, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Composite material, Instrumentation, Elastic modulus, lcsh:QH301-705.5, Fluid Flow and Transfer Processes, biocomposites, lcsh:T, Process Chemistry and Technology, General Engineering, Nanoindentation, 021001 nanoscience & nanotechnology, hemp fibre, lcsh:QC1-999, 0104 chemical sciences, Computer Science Applications, chemistry, lcsh:Biology (General), lcsh:QD1-999, surface energy, lcsh:TA1-2040, Polycaprolactone, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], 0210 nano-technology, lcsh:Engineering (General). Civil engineering (General), lcsh:Physics, nano-mechanical properties
Abstract: International audience; The quest for sustainable, low-cost and environmental friendly engineering materials has increased the application of natural fiber-reinforced polymer (FRP) composite. This paper experimentally investigates the effects of variable mean hemp fiber (HF) aspect ratios (ARs) of 00 (neat), aspect ratios AR_19, AR_26, AR_30 and AR_38 on nano-mechanical (hardness, modulus, elasticity and plasticity), surface and thermal properties of hemp fiber/polycaprolactone (HF/PCL) biocomposites. These biocomposites were characterized by nanoindentation, contact angle, surface energy, thermogravimetric analysis (TGA), thermal conductivity and differential scanning calorimetry (DSC) techniques. After nanoindentation and thermal conductivity tests, the results obtained evidently show that the HF/PCL sample with aspect ratio (AR_26) recorded optimal values. These values include maximum hardness of approximately 0.107 GPa, elastic modulus of 1.094 GPa, and plastic and elastic works of 1.580 and 1.210 nJ, respectively as well as maximum thermal conductivity of 0.2957 W/mK, when compared with other samples. Similarly, the optimal sample exhibits highest main degradable temperature and degree of crystallinity of 432 ℃ and 60.6%, respectively. Further results obtained for the total surface energies and contact angles of these samples with glycerol and distilled water are significant for their materials selection, design, manufacturing and various applications.
Published: 2020

28. Introducing the NewHorizon simulation: Galaxy properties with resolved internal dynamics across cosmic time

Author: R. S. Beckmann, Julien Devriendt, Hoseung Choi, Sugata Kaviraj, R. A. Jackson, Garreth Martin, Clotilde Laigle, Taysun Kimm, Min-Jung Park, Frédéric Bournaud, Sukyoung K. Yi, Katarina Kraljic, Marta Volonteri, Christophe Pichon, Sebastien Peirani, Yohan Dubois, Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Théorique - UMR CNRS 3681 (IPHT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), World Institute of Kimchi [Gwangju], University of Oxford Astrophysics, University of Hertfordshire [Hatfield] (UH), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), ‎ Seoul Natl Univ, Dept Archaeol, Seoul 08826, South Korea, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Stellar kinematics, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, methods: numerical, 0103 physical sciences, Galaxy formation and evolution, 010303 astronomy & astrophysics, galaxies: kinematics and dynamics, Astrophysics::Galaxy Astrophysics, Physics, COSMIC cancer database, 010308 nuclear & particles physics, Star formation, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, galaxies: general, Galaxy, Redshift, Interstellar medium, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), galaxies: stellar content, Halo, galaxies: evolution, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Hydrodynamical cosmological simulations are increasing their level of realism by considering more physical processes and having greater resolution or larger statistics. However, usually either the statistical power of such simulations or the resolution reached within galaxies are sacrificed. Here, we introduce the NewHorizon project in which we simulate at high resolution a zoom-in region of $\sim(16\,\rm Mpc)^3$ that is larger than a standard zoom-in region around a single halo and is embedded in a larger box. A resolution of up to 34 pc is reached within galaxies; this allows the simulation to capture the multi-phase nature of the interstellar medium and the clumpy nature of the star formation process in galaxies. In this introductory paper, we present several key fundamental properties of galaxies and their black holes, including the galaxy mass function, cosmic star formation rate, galactic metallicities, the Kennicutt-Schmidt relation, the stellar-to-halo mass relation, galaxy sizes, stellar kinematics and morphology, gas content within galaxies and its kinematics, and the black hole mass and spin properties over time. The various scaling relations are broadly reproduced by NewHorizon with some differences with the standard observables. Owing to its exquisite spatial resolution, NewHorizon captures the inefficient process of star formation in galaxies, which evolve over time from being more turbulent, gas rich, and star bursting at high redshift. These high-redshift galaxies are also more compact, and they are more elliptical and clumpier until the level of internal gas turbulence decays enough to allow for the formation of discs. The NewHorizon simulation gives access to a broad range of galaxy formation and evolution physics at low-to-intermediate stellar masses, which is a regime that will become accessible in the near future through surveys such as the LSST., Comment: 29 pages, 28 figures, A&A accepted
Published: 2020
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29. Black hole mergers from dwarf to massive galaxies with the NewHorizon and Horizon-AGN simulations

Author: R. A. Jackson, Christopher J. Conselice, Marta Volonteri, Sukyoung K. Yi, Maxime Trebitsch, Christophe Pichon, R. S. Beckmann, Monica Colpi, Katarina Kraljic, Sébastien Peirani, Yohan Dubois, Garreth Martin, Hugo Pfister, Julien Devriendt, Massimo Dotti, Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Dark Cosmology Centre (DARK), Niels Bohr Institute [Copenhagen] (NBI), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)-Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Dipartimento di Fisica 'Giuseppe Occhialini' = Department of Physics 'Giuseppe Occhialini' [Milano-Bicocca], Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Istituto Nazionale di Fisica Nucleare, Universita Milano-Bicocca (INFN), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB)- Istituto Nazionale di Fisica Nucleare (INFN), Centre for Astronomy and Particle Theory, University of Nottingham, Steward Observatory, University of Arizona, Korea Astronomy and Space Science Institute (KASI), Okayama University, Centre for Astrophysics Research [Hatfield], University of Hertfordshire [Hatfield] (UH), Institute for Astronomy [Edinburgh] (IfA), University of Edinburgh, Max-Planck-Institut für Astronomie (MPIA), Max-Planck-Gesellschaft, Yonsei University Observatory, Oxford Astrophysics, University of Oxford [Oxford], Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Volonteri, M, Pfister, H, Beckmann, R, Dubois, Y, Colpi, M, Conselice, C, Dotti, M, Martin, G, Jackson, R, Kraljic, K, Pichon, C, Trebitsch, M, Yi, S, Devriendt, J, and Peirani, S
Subjects: ACTIVE GALACTIC NUCLEI, Time delays, Population, FOS: Physical sciences, ORBITAL DECAY, FREQUENCY GRAVITATIONAL-WAVES, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, DARK, STAR-FORMATION, Physical cosmology, methods: numerical, Pulsar, 0103 physical sciences, Dynamical friction, education, POST-NEWTONIAN EVOLUTION, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, Astrophysics::Galaxy Astrophysics, Dwarf galaxy, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, ILLUSTRIS PROJECT, education.field_of_study, Quasars: supermassive black hole, 010308 nuclear & particles physics, Gravitational wave, supermassive black holes [quasars], quasars: supermassive black holes, numerical [methods], Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Galaxy, BINARY-SYSTEMS, COSMOLOGICAL SIMULATIONS, gravitational waves, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Astrophysics of Galaxies (astro-ph.GA), GROWTH, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Massive black hole (MBH) coalescences are powerful sources of low-frequency gravitational waves. To study these events in the cosmological context we need to trace the large-scale structure and cosmic evolution of a statistical population of galaxies, from dim dwarfs to bright galaxies. To cover such a large range of galaxy masses, we analyse two complementary simulations: Horizon-AGN with a large volume and low resolution which tracks the high-mass (> 1e7 Msun) MBH population, and NewHorizon with a smaller volume but higher resolution that traces the low-mass (< 1e7 Msun) MBH population. While Horizon-AGN can be used to estimate the rate of inspirals for Pulsar Timing Arrays, NewHorizon can investigate MBH mergers in a statistical sample of dwarf galaxies for LISA, which is sensitive to low-mass MBHs. We use the same method to analyse the two simulations, post-processing MBH dynamics to account for time delays mostly determined by dynamical friction and stellar hardening. In both simulations, MBHs typically merge long after the galaxies do, so that the galaxy morphology at the time of the MBH merger is no longer determined by the galaxy merger from which the MBH merger originated. These time delays cause a loss of high-z MBH coalescences, shifting the peak of the MBH merger rate to z~1-2. This study shows how tracking MBH mergers in low-mass galaxies is crucial to probing the MBH merger rate for LISA and investigate the properties of the host galaxies., MNRAS in press
Published: 2020

30. Pharmacological principles guiding prolonged glucocorticoid treatment in ARDS

Author: Gianfranco Umberto Meduri, George P. Chrousos, Dijillali Annane, Barbara Ruaro, Bernd Meibohm, Bram Rochwerg, Amanda Busby, Marco Confalonieri, The University of Tennessee Health Science Center [Memphis] (UTHSC), Infection et inflammation (2I), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Trieste, University of Athens Medical School [Athens], McMaster University [Hamilton, Ontario], University of Hertfordshire [Hatfield] (UH), The authors thank Professor William J. Jusko, PhD, University at Buffalo School of Pharmacy and Pharmaceutical Sciences for critical review of the manuscript and Barbara Wade for her linguistic advice., Gianfranco Umberto Meduri, Djillali, Annane, Confalonieri, Marco, Chrousos, George P., Bram, Rochwerg, Amanda, Busby, Barbara Ruaro &amp, Bernd, Meibohm, and Ruaro, Barbara
Subjects: ARDS, Hypothalamo-Hypophyseal System, [SDV]Life Sciences [q-bio], Pituitary-Adrenal System, Review, Glucocorticoid receptor, Pharmacology, Critical Care and Intensive Care Medicine, Methylprednisolone, law.invention, 03 medical and health sciences, 0302 clinical medicine, Glucocorticoid, Randomized controlled trial, law, medicine, Receptor affinity, Humans, Glucocorticoids, Dexamethasone, Respiratory Distress Syndrome, Clinical pharmacology, Pharmacodynamic, Acute respiratory distress syndrome, Randomized trial, Duration, business.industry, 030208 emergency & critical care medicine, medicine.disease, 3. Good health, 030228 respiratory system, Pharmacodynamics, business, medicine.drug
Abstract: Current literature addressing the pharmacological principles guiding glucocorticoid (GC) administration in ARDS is scant. This paucity of information may have led to the heterogeneity of treatment protocols and misinterpretation of available findings. GCs are agonist compounds that bind to the GC receptor (GR) producing a pharmacological response. Clinical efficacy depends on the magnitude and duration of exposure to GR. We updated the meta-analysis of randomized trials investigating GC treatment in ARDS, focusing on treatment protocols and response. We synthesized the current literature on the role of the GR in GC therapy including genomic and non-genomic effects, and integrated current clinical pharmacology knowledge of various GCs, including hydrocortisone, methylprednisolone and dexamethasone. This review addresses the role dosage, timing of initiation, mode of administration, duration, and tapering play in achieving optimal response to GC therapy in ARDS. Based on RCTs’ findings, GC plasma concentration–time profiles, and pharmacodynamic studies, optimal results are most likely achievable with early intervention, an initial bolus dose to achieve close to maximal GRα saturation, followed by a continuous infusion to maintain high levels of response throughout the treatment period. In addition, patients receiving similar GC doses may experience substantial between-patient variability in plasma concentrations affecting clinical response. GC should be dose-adjusted and administered for a duration targeting clinical and laboratory improvement, followed by dose-tapering to achieve gradual recovery of the suppressed hypothalamic–pituitary–adrenal (HPA) axis. These findings have practical clinical relevance. Future RCTs should consider these pharmacological principles in the study design and interpretation of findings. Electronic supplementary material The online version of this article (10.1007/s00134-020-06289-8) contains supplementary material, which is available to authorized users.
Published: 2020

31. Performance Analysis of Cell-Free Massive MIMO Systems: A Stochastic Geometry Approach

Author: Marco Di Renzo, Symeon Chatzinotas, Pandelis Kourtessis, Anastasios K. Papazafeiropoulos, John M. Senior, University of Hertfordshire [Hatfield] (UH), Laboratoire des signaux et systèmes (L2S), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Luxembourg [Luxembourg], and National Research Fund, Luxembourg [sponsor]
Subjects: FOS: Computer and information sciences, Computer Networks and Communications, Computer science, Computer Science - Information Theory, stochastic geometry, MIMO, Aerospace Engineering, Duplex (telecommunications), 02 engineering and technology, Topology, heterogeneous networks, 0203 mechanical engineering, Telecommunications link, Cell-free massive MIMO systems, Electrical and Electronic Engineering, Computer Science::Information Theory, Computer science [C05] [Engineering, computing & technology], Information Theory (cs.IT), coverage probability, 020302 automobile design & engineering, Sciences informatiques [C05] [Ingénierie, informatique & technologie], achievable rate, Automotive Engineering, Stochastic geometry, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Communication channel
Abstract: Cell-free (CF) massive multiple-input-multiple-output (MIMO) has emerged as an alternative deployment for conventional cellular massive MIMO networks. Prior works relied on the strong assumption (quite idealized) that the APs are uniformly distributed, and actually, this randomness was considered during the simulation and not in the analysis. However, in practice, ongoing and future networks become denser and increasingly irregular. Having this in mind, we consider that the AP locations are modeled by means of a Poisson point process (PPP) which is a more realistic model for the spatial randomness than a grid or uniform deployment. In particular, by virtue of stochastic geometry tools, we derive both the downlink coverage probability and achievable rate. Notably, this is the only work providing the coverage probability and shedding light on this aspect of CF massive MIMO systems. Focusing on the extraction of interesting insights, we consider small-cells (SCs) as a benchmark for comparison. Among the findings, CF massive MIMO systems achieve both higher coverage and rate with comparison to SCs due to the properties of favorable propagation, channel hardening, and interference suppression. Especially, we showed for both architectures that increasing the AP density results in a higher coverage which saturates after a certain value and increasing the number of users decreases the achievable rate but CF massive MIMO systems take advantage of the aforementioned properties, and thus, outperform SCs. In general, the performance gap between CF massive MIMO systems and SCs is enhanced by increasing the AP density. Another interesting observation concerns that a higher path-loss exponent decreases the rate while the users closer to the APs affect more the performance in terms of the rate., Comment: 14 pages, accepted in IEEE TVT
Published: 2020

32. High-resolution, 3D radiative transfer modelling

Author: Emmanuel M. Xilouris, Pieter De Vis, Jacopo Fritz, Sébastien Viaene, A. Nersesian, Viviana Casasola, Frédéric Galliano, Aleksandr V. Mosenkov, Simone Bianchi, Jonathan Ivor Davies, S. Verstocken, Wouter Dobbels, Ana Trčka, Ilse De Looze, Christopher J. R. Clark, Maud Galametz, Anthony P. Jones, Maarten Baes, Nathalie Ysard, Suzanne C. Madden, National Technical University of Athens [Athens] (NTUA), National Observatory of Athens (NOA), Sterrenkundig Observatorium, Universiteit Gent = Ghent University (UGENT), University of Hertfordshire [Hatfield] (UH), INAF - Osservatorio Astrofisico di Arcetri (OAA), Istituto Nazionale di Astrofisica (INAF), Istituto di Radioastronomia [Bologna] (IRA), Space Telescope Science Institute (STSci), Cardiff University, University College of London [London] (UCL), Instituto de Radioastronomía y Astrofísica (IRyA), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), The Central Astronomical Observatory of the Russian Academy of Sciences [Pulkovo], Russian Academy of Sciences [Moscow] (RAS), St Petersburg State University (SPbU), European Project: 606847,EC:FP7:SPA,FP7-SPACE-2013-1,DUSTPEDIA(2014), Universiteit Gent, Universidad Nacional Autónoma de México (UNAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: INFRARED-EMISSION, Extinction (astronomy), FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, STAR-FORMATION, Luminosity, CENTRAL REGION, Bulge, 0103 physical sciences, Radiative transfer, Astrophysics::Solar and Stellar Astrophysics, NEARBY GALAXIES, EDGE-ON GALAXIES, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, Cosmic dust, Physics, infrared: ISM, Spiral galaxy, ISM [galaxies], 010308 nuclear & particles physics, Star formation, extinction, ISM [infrared], Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Galaxy, SPECTRAL ENERGY-DISTRIBUTION, Physics and Astronomy, Space and Planetary Science, radiative transfer, Astrophysics of Galaxies (astro-ph.GA), MULTIPLE-SCATTERING, CLUMPY MEDIA, dust, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], SPIRAL GALAXIES, INTERSTELLAR DUST, galaxies: ISM
Abstract: Context. Dust in late-type galaxies in the local Universe is responsible for absorbing approximately one third of the energy emitted by stars. It is often assumed that dust heating is mainly attributable to the absorption of ultraviolet and optical photons emitted by the youngest (≤100 Myr) stars. Consequently, thermal re-emission by dust at far-infrared wavelengths is often linked to the star-formation activity of a galaxy. However, several studies argue that the contribution to dust heating by much older stellar populations might be more significant than previously thought. Advances in radiation transfer simulations finally allow us to actually quantify the heating mechanisms of diffuse dust by the stellar radiation field. Aims. As one of the main goals in the DustPedia project, we have developed a framework to construct detailed 3D stellar and dust radiative transfer models for nearby galaxies. In this study, we analyse the contribution of the different stellar populations to the dust heating in four nearby face-on barred galaxies: NGC 1365, M 83, M 95, and M 100. We aim to quantify the fraction directly related to young stellar populations, both globally and on local scales, and to assess the influence of the bar on the heating fraction. Methods. From 2D images we derive the 3D distributions of stars and dust. To model the complex geometries, we used SKIRT, a state-of-the-art 3D Monte Carlo radiative transfer code designed to self-consistently simulate the absorption, scattering, and thermal re-emission by the dust for arbitrary 3D distributions. Results. We derive global attenuation laws for each galaxy and confirm that galaxies of high specific star-formation rate have shallower attenuation curves and weaker UV bumps. On average, 36.5% of the bolometric luminosity is absorbed by dust in our galaxy sample. We report a clear effect of the bar structure on the radial profiles of the dust-heating fraction by the young stellar populations, and the dust temperature. We find that the young stellar populations are the main contributors to the dust heating, donating, on average ∼59% of their luminosity to this purpose throughout the galaxy. This dust-heating fraction drops to ∼53% in the bar region and ∼38% in the bulge region where the old stars are the dominant contributors to the dust heating. We also find a strong link between the heating fraction by the young stellar populations and the specific star-formation rate.
Published: 2020

33. High-resolution, 3D radiative transfer modelling IV. AGN-powered dust heating in NGC 1068

Author: Emmanuel M. Xilouris, Anthony P. Jones, Nathalie Ysard, A. Nersesian, Frédéric Galliano, Christopher J. R. Clark, Simone Bianchi, Ana Trčka, I. De Looze, Maud Galametz, Viviana Casasola, Sébastien Viaene, John K. Davies, S. C. Madden, Jacopo Fritz, Aleksandr V. Mosenkov, Wouter Dobbels, S. Verstocken, Letizia P. Cassarà, Maarten Baes, P. De Vis, University of Hertfordshire [Hatfield] (UH), Sterrenkundig Observatorium, Universiteit Gent = Ghent University (UGENT), National Observatory of Athens (NOA), National Technical University of Athens [Athens] (NTUA), Instituto de Radioastronomía y Astrofísica (IRyA), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), INAF - Osservatorio Astrofisico di Arcetri (OAA), Istituto Nazionale di Astrofisica (INAF), Istituto di Radioastronomia [Bologna] (IRA), Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano (IASF-MI), Space Telescope Science Institute (STSci), Cardiff University, University College of London [London] (UCL), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), The Central Astronomical Observatory of the Russian Academy of Sciences [Pulkovo], Russian Academy of Sciences [Moscow] (RAS), St Petersburg State University (SPbU), European Project: 606847,EC:FP7:SPA,FP7-SPACE-2013-1,DUSTPEDIA(2014), Universiteit Gent, Universidad Nacional Autónoma de México (UNAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: ACTIVE GALACTIC NUCLEI, Active galactic nucleus, Astrophysics::High Energy Astrophysical Phenomena, Extinction (astronomy), FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, galaxies: individual: NGC 1068, 0103 physical sciences, STAR-FORMING GALAXIES, Astrophysics::Solar and Stellar Astrophysics, NEARBY GALAXIES, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, TORUS, Cosmic dust, CALIBRATION, Physics, Spiral galaxy, ISM [galaxies], 010308 nuclear & particles physics, Star formation, extinction, Astronomy and Astrophysics, Quasar, Astrophysics - Astrophysics of Galaxies, Galaxy, Interstellar medium, SPECTRAL ENERGY-DISTRIBUTION, STELLAR, Physics and Astronomy, Space and Planetary Science, individual: NGC 1068 [galaxies], Astrophysics of Galaxies (astro-ph.GA), dust, Astrophysics::Earth and Planetary Astrophysics, SKY SURVEY, EMISSION, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], INTERSTELLAR DUST, galaxies: ISM
Abstract: Dust emission, an important diagnostic of star formation and ISM mass throughout the Universe, can be powered by sources unrelated to ongoing star formation. In the framework of the DustPedia project we have set out to disentangle the radiation of the ongoing star formation from that of the older stellar populations. This is done through detailed, 3D radiative transfer simulations of face-on spiral galaxies. In this particular study, we focus on NGC 1068, which contains an active galactic nucleus (AGN). The effect of diffuse dust heating by AGN (beyond the torus) was so far only investigated for quasars. This additional dust heating source further contaminates the broadband fluxes on which classic galaxy modelling tools rely to derive physical properties. We aim to fit a realistic model to the observations of NGC 1068 and quantify the contribution of the several dust heating sources. Our model is able to reproduce the global spectral energy distribution of the galaxy. It matches the resolved optical and infrared images fairly well, but deviates in the UV and the submm. We find a strong wavelength dependency of AGN contamination to the broadband fluxes. It peaks in the MIR, drops in the FIR, but rises again at submm wavelengths. We quantify the contribution of the dust heating sources in each 3D dust cell and find a median value of 83% for the star formation component. The AGN contribution is measurable at the percentage level in the disc, but quickly increases in the inner few 100 pc, peaking above 90%. This is the first time the phenomenon of an AGN heating the diffuse dust beyond its torus is quantified in a nearby star-forming galaxy. NGC 1068 only contains a weak AGN, meaning this effect can be stronger in galaxies with a more luminous AGN. This could significantly impact the derived star formation rates and ISM masses for such systems., Comment: 18 pages, 11 figures, accepted for publication in A&A
Published: 2020
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34. Hybrid estimator-based harmonic robust grid synchronization technique

Author: Hafiz Ahmed, Mohamed Benbouzid, Miao Lin Pay, Elhoussin Elbouchikhi, Yassine Amirat, Coventry University (UK), Coventry University, University of Hertfordshire [Hatfield] (UH), Institut de Recherche Dupuy de Lôme (IRDL), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Centre National de la Recherche Scientifique (CNRS), Energie et Systèmes Electromécaniques (LABISEN-ESE), Laboratoire ISEN (L@BISEN), and Institut supérieur de l'électronique et du numérique (ISEN)-YNCREA OUEST (YO)-Institut supérieur de l'électronique et du numérique (ISEN)-YNCREA OUEST (YO)
Subjects: Grid voltage, Computer science, 020209 energy, 020208 electrical & electronic engineering, Energy Engineering and Power Technology, Estimator, 02 engineering and technology, Grid synchronization, [SPI]Engineering Sciences [physics], Control theory, Robustness (computer science), Integrator, Harmonics, 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering, Harmonic oscillator, ComputingMilieux_MISCELLANEOUS, DC bias
Abstract: Harmonic robust grid synchronization technique has been studied in this paper. This implies the estimation of phase and frequency of single-phase grid voltage signal. Motivated by recent developments in linear harmonic oscillator based technique, this paper first propose an adaptive observer based solution that has the potential to speed-up the dynamic performance with respect to other generalized integrator type techniques. However, this may decrease the robustness of the proposed technique in the presence of harmonics and or DC bias. To overcome this issue, a hybrid estimator is proposed. This estimator is comprised of a band-pass type pre-loop filter and the initially proposed adaptive observer. Local stability and tuning of the adaptive observer are provided for the nominal case. In the presence of harmonics, small-signal modeling and tuning of the hybrid estimator are provided as well. Finally, hardware-in-the-loop (HIL) comparative experimental results are provided with similar other recently proposed techniques in the literature. Experimental results demonstrate the suitability of the proposed techniques.
Published: 2019

35. The role of mergers in driving morphological transformation over cosmic time

Author: Sugata Kaviraj, Yohan Dubois, Julien Devriendt, Christophe Pichon, Garreth Martin, University of Hertfordshire [Hatfield] (UH), University of Oxford [Oxford], Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institute for Astronomy [Edinburgh] (IfA), University of Edinburgh, and Korea Institute for Advanced Study (KIAS)
Subjects: Physics, education.field_of_study, Stellar mass, 010308 nuclear & particles physics, Population, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Astrophysics - Astrophysics of Galaxies, 01 natural sciences, Galaxy, Accretion (astrophysics), Morphological transformation, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), 0103 physical sciences, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], education, 010303 astronomy & astrophysics, Cosmic time, Astrophysics::Galaxy Astrophysics
Abstract: Understanding the processes that trigger morphological transformation is central to understanding how and why the Universe transitions from being disc-dominated at early epochs to having the morphological mix that is observed today. We use Horizon-AGN, a cosmological hydrodynamical simulation, to perform a comprehensive study of the processes that drive morphological change in massive (M > 10^10 MSun) galaxies over cosmic time. We show that (1) essentially all the morphological evolution in galaxies that are spheroids at z=0 is driven by mergers with mass ratios greater than 1:10, (2) major mergers alone cannot produce today's spheroid population -- minor mergers are responsible for a third of all morphological transformation over cosmic time and are its dominant driver after z~1, (3) prograde mergers trigger milder morphological transformation than retrograde mergers -- while both types of events produce similar morphological changes at z>2, the average change due to retrograde mergers is around twice that due to their prograde counterparts at z~0, (4) remnant morphology depends strongly on the gas fraction of a merger, with gas-rich mergers routinely re-growing discs, and (5) at a given stellar mass, discs do not exhibit drastically different merger histories from spheroids -- disc survival in mergers is driven by acquisition of cold gas (via cosmological accretion and gas-rich interactions) and a preponderance of prograde mergers in their merger histories., Accepted for publication in MNRAS
Published: 2018

36. The applicability of physical optics in the millimetre and sub-millimetre spectral region. Part II: Application to a three-component model of ice cloud and its evaluation against the bulk single-scattering properties of various other aggregate models

Author: Chawn Harlow, Anthony J. Baran, Evelyn Hesse, Hiroshi Ishimoto, Odran Sourdeval, United Kingdom Met Office [Exeter], Leipziger Institut für Meteorologie (LIM), Universität Leipzig, Centre for Atmospheric and Instrumentation Research [Hatfield] (CAIR), and University of Hertfordshire [Hatfield] (UH)
Subjects: Aggregates, Materials science, 010504 meteorology & atmospheric sciences, 01 natural sciences, Light scattering, 010309 optics, Optics, 0103 physical sciences, Sub-millimetre, Voronoi tessellation, Spectroscopy, 0105 earth and related environmental sciences, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Ice cloud, Radiation, Aggregate (composite), Ice crystals, business.industry, Scattering, Ice, Remote sensing, Particle size distribution, Physical optics, Atomic and Molecular Physics, and Optics, Computational physics, Particle-size distribution, Electromagnetic scattering, Single-scattering, business, Voronoi diagram, Microwave
Abstract: International audience; The bulk single-scattering properties of various randomly oriented aggregate ice crystal models are compared and contrasted at a number of frequencies between 89 and 874 GHz. The model ice particles consist of the ten-branched plate aggregate, five-branched plate aggregate, eight-branched hexagonal aggregate, Voronoi ice aggregate, six-branched hollow bullet rosette, hexagonal column of aspect ratio unity, and the ten-branched hexagonal aggregate. The bulk single-scattering properties of the latter two ice particle models have been calculated using the light scattering methods described in Part I, which represent the two most extreme members of an ensemble model of cirrus ice crystals. In Part I, it was shown that the method of physical optics could be combined with the T-matrix at a size parameter of about 18 to compute the bulk integral ice optical properties and the phase function in the microwave to sufficient accuracy to be of practical value. Here, the bulk single-scattering properties predicted by the two ensemble model members and the Voronoi model are shown to generally bound those of all other models at frequencies between 89 and 874 GHz, thus representing a three-component model of ice cloud that can be generally applied to the microwave, rather than using many differing ice particle models. Moreover, the Voronoi model and hollow bullet rosette scatter similarly to each other in the microwave. Furthermore, from the various comparisons, the importance of assumed shapes of the particle size distribution as well as cm-sized ice aggregates is demonstrated.
Published: 2018

37. Energetics of Deep Alpine Valleys in Pooling and Draining Configurations

Author: Chantal Staquet, Charles Chemel, Gabriele Arduini, Laboratoire des Écoulements Géophysiques et Industriels [Grenoble] (LEGI ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University of Hertfordshire [Hatfield] (UH), and National Center of Atmospheric Science
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Atmospheric Science, Heat budget, 010504 meteorology & atmospheric sciences, Planetary boundary layer, 0208 environmental biotechnology, Energetics, Flow (psychology), Pooling, Diabatic, 02 engineering and technology, 01 natural sciences, 020801 environmental engineering, Boundary layer, 13. Climate action, Weather Research and Forecasting Model, Geomorphology, ComputingMilieux_MISCELLANEOUS, Geology, 0105 earth and related environmental sciences
Abstract: The Weather Research and Forecasting Model is used to investigate the nocturnal atmospheric boundary layer in a valley that opens either on a wider valley (draining configuration) or on a narrower valley (pooling configuration). One draining case and three weak to strong pooling cases are considered. Results show that the structure of the nocturnal boundary layer is substantially different for the draining and pooling configurations. Greater pooling corresponds with a deeper and colder boundary layer. Down-valley winds are weaker for pooling and draining configurations than in an equivalent valley opening directly on a plain. For the strong pooling case, an up-valley flow develops from the narrower to the wider valley during the evening transition, affecting the mass budget of the wider valley during that period. Considering the heat budget of the valley system, the contribution of the diabatic processes, when appropriately weighted, hardly varies along the valley axis. Conversely, the contribution of advection varies along the valley axis: it decreases for a pooling configuration and increases for a draining configuration. Consequently, for a pooling configuration, the heat transfer between the valley and the plain is reduced, thereby increasing the temperature difference between them. For the strong pooling case, this temperature difference can be explained by the valley-volume effect once the down-valley flow has developed. This occurs in a valley when the “extra” heat loss within the valley due to the surface sensible heat flux balances the heat input due to advection.
Published: 2017

38. A Novel Reinforcement-Based Paradigm for Children to Teach the Humanoid Kaspar Robot

Author: Luke Jai Wood, Costas S. Tzafestas, Farshid Amirabdollahian, Ben Robins, Kerstin Dautenhahn, Mehdi Khamassi, Gabriella Lakatos, Abolfazl Zaraki, University of Hertfordshire [Hatfield] (UH), Institut cellule souche et cerveau / Stem Cell and Brain Research Institute (U1208 Inserm - UCBL1 / SBRI - USC 1361 INRAE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), School of of Electrical and Computer Engineering [Athens] (School of E.C.E), National Technical University of Athens [Athens] (NTUA), University of Waterloo [Waterloo], Institut des Systèmes Intelligents et de Robotique (ISIR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (MITI ROBAUTISTE and PICS 279521), European Project: 687831,H2020,H2020-ICT-2015,BabyRobot(2016), Gestionnaire, HAL Sorbonne Université 5, and Child-Robot Communication and Collaboration: Edutainment, Behavioural Modelling and Cognitive Development in Typically Developing and Autistic Spectrum Children - BabyRobot - - H20202016-01-01 - 2018-12-31 - 687831 - VALID
Subjects: General Computer Science, Social Psychology, Process (engineering), media_common.quotation_subject, Autism, Control (management), 050105 experimental psychology, Human–robot interaction, 03 medical and health sciences, 0302 clinical medicine, Reinforcement learning, medicine, Autonomous robotics, [INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO], 0501 psychology and cognitive sciences, Electrical and Electronic Engineering, Reinforcement learning algorithm, Reinforcement, media_common, Enthusiasm, business.industry, Teaching, [INFO.INFO-RB] Computer Science [cs]/Robotics [cs.RO], 05 social sciences, Robotics, medicine.disease, Human-Computer Interaction, Philosophy, Control and Systems Engineering, Robot, Children social skills, Artificial intelligence, business, Psychology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract: This paper presents a contribution aiming at testing novel child–robot teaching schemes that could be used in future studies to support the development of social and collaborative skills of children with autism spectrum disorders (ASD). We present a novel experiment where the classical roles are reversed: in this scenario the children are the teachers providing positive or negative reinforcement to the Kaspar robot in order for it to learn arbitrary associations between different toy names and the locations where they are positioned. The objective is to stimulate interaction and collaboration between children while teaching the robot, and also provide them tangible examples to understand that sometimes learning requires several repetitions. To facilitate this game, we developed a reinforcement learning algorithm enabling Kaspar to verbally convey its level of uncertainty during the learning process, so as to better inform the children about the reasons behind its successes and failures. Overall, 30 typically developing (TD) children aged between 7 and 8 (19 girls, 11 boys) and 9 children with ASD performed 25 sessions (16 for TD; 9 for ASD) of the experiment in groups, and managed to teach Kaspar all associations in 2 to 7 trials. During the course of study Kaspar only made rare unexpected associations (2 perseverative errors and 2 win-shifts, within a total of 314 trials), primarily due to exploratory choices, and eventually reached minimal uncertainty. Thus, the robot’s behaviour was clear and consistent for the children, who all expressed enthusiasm in the experiment.
Published: 2019

39. Massive spheroids can form in single minor mergers

Author: Garreth Martin, Clotilde Laigle, R. A. Jackson, Christophe Pichon, Sugata Kaviraj, Yohan Dubois, Julien Devriendt, University of Hertfordshire [Hatfield] (UH), Department of Physics [Oxford], University of Oxford [Oxford], Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of Oxford, École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics, education.field_of_study, Stellar mass, 010308 nuclear & particles physics, Star formation, Population, Spheroid, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Astrophysics - Astrophysics of Galaxies, Galaxy, Morphological transformation, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), 0103 physical sciences, Galaxy formation and evolution, Satellite orbit, education, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, ComputingMilieux_MISCELLANEOUS
Abstract: Understanding how rotationally-supported discs transform into dispersion-dominated spheroids is central to our comprehension of galaxy evolution. Morphological transformation is largely merger-driven. While major mergers can efficiently create spheroids, recent work has highlighted the significant role of other processes, like minor mergers, in driving morphological change. Given their rich merger histories, spheroids typically exhibit large fractions of `ex-situ' stellar mass, i.e. mass that is accreted, via mergers, from external objects. This is particularly true for the most massive galaxies, whose stellar masses typically cannot be attained without a large number of mergers. Here, we explore an unusual population of extremely massive (M* > 10^11 MSun) spheroids, in the Horizon-AGN simulation, which exhibit anomalously low ex-situ mass fractions, indicating that they form without recourse to significant merging. These systems form in a single minor-merger event (with typical merger mass ratios of 0.11 - 0.33), with a specific orbital configuration, where the satellite orbit is virtually co-planar with the disc of the massive galaxy. The merger triggers a catastrophic change in morphology, over only a few hundred Myrs, coupled with strong in-situ star formation. While this channel produces a minority (~5 per cent) of such galaxies, our study demonstrates that the formation of at least some of the most massive spheroids need not involve major mergers -- or any significant merging at all -- contrary to what is classically believed., Accepted for publication in MNRAS, 12 pages, 6 figures
Published: 2019

40. The Bi-objective Periodic Closed Loop Network Design Problem

Author: Elham Jelodari Mamaghani, Soheil Davari, Laboratoire d'Optimisation des Systèmes Industriels (LOSI), Institut Charles Delaunay (ICD), Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Troyes (UTT)-Centre National de la Recherche Scientifique (CNRS), and University of Hertfordshire [Hatfield] (UH)
Subjects: Service (business), 0209 industrial biotechnology, Operations research, Total cost, Computer science, Circular economy, Supply chain, General Engineering, 02 engineering and technology, Computer Science Applications, Network planning and design, Product (business), 020901 industrial engineering & automation, Artificial Intelligence, 0202 electrical engineering, electronic engineering, information engineering, [INFO.INFO-SY]Computer Science [cs]/Systems and Control [cs.SY], 020201 artificial intelligence & image processing, Set (psychology)
Abstract: International audience; Reverse supply chains are becoming a crucial part of retail supply chains given the recent reforms in the consumers’ rights and the regulations by governments. This has motivated companies around the world to adopt zero-landfill goals and move towards circular economy to retain the product’s value during its whole life cycle. However, designing an efficient closed loop supply chain is a challenging undertaking as it presents a set of unique challenges, mainly owing to the need to handle pickups and deliveries at the same time and the necessity to meet the customer requirements within a certain time limit. In this paper, we model this problem as a bi-objective periodic location routing problem with simultaneous pickup and delivery as well as time windows and examine the performance of two procedures, namely NSGA-II and NRGA, to solve it. The goal is to find the best locations for a set of depots, allocation of customers to these depots, allocation of customers to service days and the optimal routes to be taken by a set of homogeneous vehicles to minimise the total cost and to minimise the overall violation from the customers’ defined time limits. Our results show that while there is not a significant difference between the two algorithms in terms of diversity and number of solutions generated, NSGA-II outperforms NRGA when it comes to spacing and runtime.
Published: 2019

41. Predicting the global far-infrared SED of galaxies via machine learning techniques

Author: Maud Galametz, A. Nersesian, Wouter Dobbels, Sébastien Viaene, Jacopo Fritz, Ana Trčka, Viviana Casasola, Frédéric Galliano, Simone Bianchi, Christopher J. R. Clark, Maarten Baes, J. I. Davies, Aleksandr V. Mosenkov, Sterrenkundig Observatorium, Universiteit Gent, University of Hertfordshire [Hatfield] (UH), INAF - Osservatorio Astrofisico di Arcetri (OAA), Istituto Nazionale di Astrofisica (INAF), Cardiff University, INAF - Osservatorio Astronomico di Bologna (OABO), Space Telescope Science Institute (STSci), Instituto de Radioastronomía y Astrofísica (IRyA), Universidad Nacional Autónoma de México (UNAM), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), The Central Astronomical Observatory of the Russian Academy of Sciences [Pulkovo], Russian Academy of Sciences [Moscow] (RAS), St Petersburg State University (SPbU), National Technical University of Athens [Athens] (NTUA), National Observatory of Athens (NOA), European Project: 606847,EC:FP7:SPA,FP7-SPACE-2013-1,DUSTPEDIA(2014), Universiteit Gent = Ghent University (UGENT), Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
Subjects: photometry, Mean squared error, ULTRAVIOLET, PECTRAL ENERGY-DISTRIBUTIONS, Energy balance, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Machine learning, computer.software_genre, 01 natural sciences, Luminosity, infrared: galaxies, galaxies, EXPLORER, MAPS, 0103 physical sciences, 010303 astronomy & astrophysics, ISM, Astrophysics::Galaxy Astrophysics, MISSION, Physics, 010308 nuclear & particles physics, business.industry, Astronomy and Astrophysics, Effective temperature, Astrophysics - Astrophysics of Galaxies, EVOLUTION, Redshift, Galaxy, MODEL, galaxies: photometry, Physics and Astronomy, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Test set, infrared, Spectral energy distribution, Artificial intelligence, SKY SURVEY, EMISSION, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], computer, INTERSTELLAR DUST, galaxies: ISM
Abstract: Dust plays an important role in shaping a galaxy's spectral energy distribution (SED). It absorbs ultraviolet (UV) to near-infrared (NIR) radiation and re-emits this energy in the far-infrared (FIR). The FIR is essential to understand dust in galaxies. However, deep FIR observations require a space mission, none of which are still active today. We aim to infer the FIR emission across six Herschel bands, along with dust luminosity, mass, and effective temperature, based on the available UV to mid-infrared (MIR) observations. We also want to estimate the uncertainties of these predictions, compare our method to energy balance SED fitting, and determine possible limitations of the model. We propose a machine learning framework to predict the FIR fluxes from 14 UV-MIR broadband fluxes. We used a low redshift sample by combining DustPedia and H-ATLAS, and extracted Bayesian flux posteriors through SED fitting. We trained shallow neural networks to predict the far-infrared fluxes, uncertainties, and dust properties. We evaluated them on a test set using a root mean square error (RMSE) in log-space. Our results (RMSE = 0.19 dex) significantly outperform UV-MIR energy balance SED fitting (RMSE = 0.38 dex), and are inherently unbiased. We can identify when the predictions are off, for example when the input has large uncertainties on WISE 22, or when the input does not resemble the training set. The galaxies for which we have UV-FIR observations can be used as a blueprint for galaxies that lack FIR data. This results in a 'virtual FIR telescope', which can be applied to large optical-MIR galaxy samples. This helps bridge the gap until the next FIR mission., 25 pages, 16 figures, accepted by A&A. Interactive figures + jupyter notebooks at https://wdobbels.github.io/FIREnet/
Published: 2019

42. New Horizon: On the Origin of the Stellar Disk and Spheroid of Field Galaxies at z = 0.7

Author: Park, Min-Jung, Yi, Sukyoung, Dubois, Yohan, Pichon, Christophe, Devriendt, Julien, Choi, Hoseung, Volonteri, Marta, Kaviraj, Sugata, Peirani, Sébastien, Kimm, Taysun, Cadiou, Corentin, Joseph Louis LAGRANGE (LAGRANGE), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Cosmologie, Astrophysique Stellaire & Solaire, de Planétologie et de Mécanique des Fluides (CASSIOPEE), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Yonsei University Observatory, Korean Institute of Advanced Studies (KIAS), Korean Institute of Advanced Studies, Department of Physics [Oxford], University of Oxford [Oxford], Institute of Theoretical Astrophysics [Oslo], University of Oslo (UiO), Centre for Astrophysics Research [Hatfield], University of Hertfordshire [Hatfield] (UH), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, and COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Angular momentum, 010504 meteorology & atmospheric sciences, Stellar mass, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Physics, Plane (geometry), Horizon, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Redshift, Galaxy, Accretion (astrophysics), Stars, Space and Planetary Science, [SDU]Sciences of the Universe [physics], Astrophysics of Galaxies (astro-ph.GA), Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: The origin of the disk and spheroid of galaxies has been a key open question in understanding their morphology. Using the high-resolution cosmological simulation, New Horizon, we explore kinematically decomposed disk and spheroidal components of 144 field galaxies with masses greater than $\rm 10^9\,M_{\odot}$ at $z=0.7$. The origins of stellar particles are classified according to their birthplace (in situ or ex situ) and their orbits at birth. Before disk settling, stars form mainly through chaotic mergers between proto-galaxies and become part of the spheroidal component. When disk settling starts, we find that more massive galaxies begin to form disk stars from earlier epochs; massive galaxies commence to develop their disks at $z\sim1-2$, while low-mass galaxies do after $z\sim1$. The formation of disks is affected by accretion as well, as mergers can trigger gas turbulence or induce misaligned gas infall that prevents galaxies from forming co-rotating disk stars. The importance of accreted stars is greater in more massive galaxies, especially in developing massive spheroids. A significant fraction of the spheroids comes from the disk stars that are perturbed, which becomes more important at lower redshifts. Some ($\sim12.5\%$) of our massive galaxies develop counter-rotating disks from the gas infall misaligned with the existing disk plane, which can last for more than a Gyr until they become the dominant component, and flip the angular momentum of the galaxy in the opposite direction. The final disk-to-total ratio of a galaxy needs to be understood in relation to its stellar mass and accretion history. We quantify the significance of the stars with different origins and provide them as guiding values., Comment: Accepted for publication in ApJ. 23 pages with 13 figures
Published: 2019

43. Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants

Author: Graham J.W. King, Yongju Huang, Vinod Kumar, Régine Delourme, Bruce D.L. Fitt, Sophie Paillard, University of Hertfordshire [Hatfield] (UH), Institut de Génétique, Environnement et Protection des Plantes (IGEPP), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-AGROCAMPUS OUEST, Southern Cross University (SCU), BB/I017585/1, Biotechnology and Biological Sciences Research Council, RD-2140021105, AHDB Cereals and Oilseeds, CH0104, Department for Environment, Food and Rural Affairs, UK Government, 5CXXXII, Felix Thornley Cobbold Agricultural Trust, GRA 3/53, Chadacre Agricultural Trust, Institut National de la Recherche Agronomique (INRA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-AGROCAMPUS OUEST, and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)
Subjects: 0106 biological sciences, 0301 basic medicine, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, Leaves, Rapeseed, QTL, Leptosphaeria maculan, Brassica, Plant Science, 01 natural sciences, Geographical Locations, Leptosphaeria maculans, Flowering Plants, Disease Resistance, 2. Zero hunger, education.field_of_study, Multidisciplinary, Plant Anatomy, Eukaryota, food and beverages, Agriculture, Plants, Spring, Europe, Horticulture, Phenotype, Medicine, Seasons, Research Article, quantitative resistance, Science, Quantitative Trait Loci, Blackleg, Population, Plant Pathogens, Crops, Biology, Petiole (botany), 03 medical and health sciences, Ascomycota, Genetics, medicine, education, Plant Diseases, Canker, fungi, Brassica napus, Organisms, Biology and Life Sciences, Plant Pathology, medicine.disease, biology.organism_classification, [SDV.BV.PEP]Life Sciences [q-bio]/Vegetal Biology/Phytopathology and phytopharmacy, Plant Leaves, 030104 developmental biology, Genetic Loci, People and Places, Earth Sciences, Doubled haploidy, Crop Science, 010606 plant biology & botany
Abstract: International audience; Key message: One QTL for resistance against Leptosphaeria maculans growth in leaves of young plants in controlled environments overlapped with one QTL detected in adult plants in field experiments. The fungal pathogen Leptosphaeria maculans initially infects leaves of oilseed rape (Brassica napus) in autumn in Europe and then grows systemically from leaf lesions along the leaf petiole to the stem, where it causes damaging phoma stem canker (blackleg) in summer before harvest. Due to the difficulties of investigating resistance to L. maculans growth in leaves and petioles under field conditions, identification of quantitative resistance typically relies on end of season stem canker assessment on adult plants. To investigate whether quantitative resistance can be detected in young plants, we first selected nine representative DH (doubled haploid) lines from an oilseed rape DY ('Darmor-bzh' × 'Yudal') mapping population segregating for quantitative resistance against L. maculans for controlled environment experiment (CE). We observed a significant correlation between distance grown by L. maculans along the leaf petiole towards the stem (r = 0.91) in CE experiments and the severity of phoma stem canker in field experiments. To further investigate quantitative trait loci (QTL) related to resistance against growth of L. maculans in leaves of young plants in CE experiments, we selected 190 DH lines and compared the QTL detected in CE experiments with QTL related to stem canker severity in stems of adult plants in field experiments. Five QTL for resistance to L. maculans growth along the leaf petiole were detected; collectively they explained 35% of the variance. Two of these were also detected in leaf lesion area assessments and each explained 10-12% of the variance. One QTL on A02 co-localized with a QTL detected in stems of adult plants in field experiments. This suggests that resistance to the growth of L. maculans from leaves along the petioles towards the stems contributes to the quantitative resistance assessed in stems of adult plants in field experiments at the end of the growing season.
Published: 2019

44. Massive star cluster formation and evolution in tidal dwarf galaxies

Author: Florent Renaud, Jeremy Fensch, Elias Brinks, Richard de Grijs, Frédéric Bournaud, Pierre-Alain Duc, Federico Lelli, Bruce G. Elmegreen, Peter M. Weilbacher, Médéric Boquien, Debra Meloy Elmegreen, Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), European Southern Observatory (ESO), Observatoire astronomique de Strasbourg (ObAS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Universidad de Antofagasta, Department of Physics and Astronomy, Vassar College, Vassar College, Computational Biology Center (IBM T.J. Watson Research Center), IBM, University of Hertfordshire [Hatfield] (UH), Macquarie University, Lund Observatory, Lund University [Lund], Leibniz-Institut für Astrophysik Potsdam (AIP), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), and Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: Metallicity, Dark matter, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 0103 physical sciences, galaxies: interactions, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, galaxies: irregular, Astrophysics::Galaxy Astrophysics, Dwarf galaxy, Physics, 010308 nuclear & particles physics, Star formation, Astronomy and Astrophysics, galaxies: dwarf, Astrophysics - Astrophysics of Galaxies, Redshift, Galaxy, Star cluster, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Globular cluster, galaxies: star formation, galaxies: star clusters: general, galaxies: stellar content, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: The formation of globular clusters remains an open debate. Dwarf starburst galaxies are efficient at forming young massive clusters with similar masses as globular clusters and may hold the key to understanding their formation. We study star cluster formation in a tidal debris - including the vicinity of three tidal dwarf galaxies - in a massive gas dominated collisional ring around NGC~5291. These dwarfs have physical parameters which differ significantly from local starbursting dwarfs. They are gas-rich, highly turbulent, have a gas metallicity already enriched up to half-solar, and are expected to be free of dark matter. The aim is to study massive star cluster formation in this as yet unexplored type of environment. We use imaging from the Hubble Space Telescope using broadband filters covering the wavelength range from the near-ultraviolet to the near-infrared. We determine the masses and ages of the cluster candidates by using the spectral energy distribution-fitting code CIGALE, carefully considering age-extinction degeneracy effects on the estimation of the physical parameters. We find that the tidal dwarf galaxies in the ring of NGC 5291 are forming star clusters with an average efficiency of $\sim40\%$, comparable to blue compact dwarf galaxies. We also find massive star clusters for which the photometry suggests that they were formed at the very birth of the tidal dwarf galaxies and have survived for several hundred million years. Therefore our study shows that extended tidal dwarf galaxies and compact clusters may be formed simultaneously. In the specific case observed here, the young star clusters are not massive enough to survive for a Hubble time. However one may speculate that similar objects at higher redshift, with higher star formation rate, might form some of the long lived globular clusters., Accepted for publication in A&A. 19 pages, 17 figures
Published: 2019

45. Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey

Author: A Patwala, Andrew L. Clark, Alan S. Rigby, R. Perveen, Muhammad Rashid, James Nolan, John G.F. Cleland, M. Komajda, Chun Shing Kwok, Mohamed Farag, Ahmad Shoaib, Keele University [Keele], University of Hull [United Kingdom], University of Hertfordshire [Hatfield] (UH), Service de Cardiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), Imperial College London, and University of Glasgow
Subjects: Male, Acute coronary syndrome, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Peripheral edema, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Risk Factors, Surveys and Questionnaires, Internal medicine, medicine, Humans, Hospital Mortality, Registries, 030212 general & internal medicine, Mortality, Aged, Retrospective Studies, Aged, 80 and over, Heart Failure, Original Paper, business.industry, Hazard ratio, Acute heart failure, General Medicine, Middle Aged, Prognosis, medicine.disease, RC666, Pathophysiology, 3. Good health, Europe, Hospitalization, Survival Rate, Clinical trial, Heart failure, Acute Disease, Cardiology, Etiology, Female, Presentation of heart failure, Presentation (obstetrics), medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: Background:\ud Heart failure is heterogeneous in aetiology, pathophysiology and presentation. Despite this diversity, clinical trials of patients hospitalized for HF deal with this problem as a single entity, which may be one reason for repeated failures. \ud \ud Methods: \ud First EuroHeart Failure Survey screened consecutive deaths and discharges of patients with suspected heart failure during 2000-2001. Patients were sorted into seven mutually exclusive hierarchical presentations: 1) with cardiac arrest/ ventricular arrhythmia; 2): with acute coronary syndrome; 3) with rapid atrial fibrillation; 4) with acute breathlessness; 5) with other symptoms/signs such as peripheral oedema ; 6) with stable symptoms and 7) others in whom the contribution of HF to admission was not clear. \ud \ud Results:\ud The 10,701 patients enrolled were classified into the above seven presentations as follows:- 260 (2%), 560 (5%), 799 (8%), 2,479 (24%), 1,040 (10%), 703 (7%), and 4,691 (45%) for which index-admission mortality was 26%, 20%, 10%, 8%, 6%, 6% and 4% respectively. Compared to those in group 7, the hazard ratios for death during the index admission were 4.9 (p=
Published: 2019

46. Impact of Along-Valley Orographic Variations on the Dispersion of Passive Tracers in a Stable Atmosphere

Author: Chantal Staquet, Charles Chemel, Julian Quimbayo-Duarte, Gabriele Arduini, Laboratoire des Écoulements Géophysiques et Industriels [Grenoble] (LEGI ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), University of Hertfordshire [Hatfield] (UH), National Center of Atmospheric Science, and European Centre for Medium-Range Weather Forecasts (ECMWF)
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Flow (psychology), stable atmosphere, 010501 environmental sciences, Environmental Science (miscellaneous), lcsh:QC851-999, Atmospheric sciences, 01 natural sciences, orographic variation, law.invention, Atmosphere, Upstream and downstream (DNA), law, Upstream (networking), Dispersion (water waves), ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Orographic lift, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Computer simulation, passive tracers, 13. Climate action, numerical simulation, Ventilation (architecture), lcsh:Meteorology. Climatology, Geology
Abstract: A numerical model is used to investigate the transport of passive tracers in an idealized Alpine valley during stable wintertime conditions after the evening transition. The valley is composed of an upstream-valley section, which opens on a narrower downstream valley section, which opens onto a plain. The ratio between the valley-floor widths of the upstream and downstream sections is either 4 (simulation P1) or 11.5 (P2). The change in the thermal structure of the atmosphere in the along-valley direction and over the plain leads to the development of an along-valley flow. This flow is up-valley in the upstream section during the first three hours of the P1 simulation, reversing to the down-valley direction afterwards, but remains up-valley during the six hours of the P2 simulation. The effect of wind dynamics on the dispersion of passive scalars is identified by tracking areas prone to stagnation, recirculation, and ventilation using the methodology developed by Allwine and Whiteman (1994). Zones identified as prone to stagnation are consistent with those of high tracer concentration in both simulations. The narrowing of the valley is found to significantly reduce ventilation in the upstream section, an observation quantified by a ventilation efficiency.
Published: 2019

47. The formation and evolution of low-surface-brightness galaxies

Author: Garreth Martin, Sugata Kaviraj, Sébastien Peirani, Yohan Dubois, Christophe Pichon, Adrianne Slyz, R. A. Jackson, Julien Devriendt, Clotilde Laigle, University of Hertfordshire [Hatfield] (UH), Department of Physics [Oxford], University of Oxford, Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), University of Edinburgh, Korea Institute for Advanced Study (KIAS), University of Oxford [Oxford], École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)
Subjects: Population, FOS: Physical sciences, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Luminosity, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], 0103 physical sciences, Galaxy formation and evolution, Astrophysics::Solar and Stellar Astrophysics, Surface brightness, structure, education, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, dwarf, Physics, education.field_of_study, 010308 nuclear & particles physics, formation, Galaxies: evolution, Astronomy and Astrophysics, Astrophysics - Astrophysics of Galaxies, Galaxy, Stars, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA)
Abstract: Our statistical understanding of galaxy evolution is fundamentally driven by objects that lie above the surface-brightness limits of current wide-area surveys (mu ~ 23 mag arcsec^-2). While both theory and small, deep surveys have hinted at a rich population of low-surface-brightness galaxies (LSBGs) fainter than these limits, their formation remains poorly understood. We use Horizon-AGN, a cosmological hydrodynamical simulation to study how LSBGs, and in particular the population of ultra-diffuse galaxies (UDGs; mu > 24.5 mag arcsec^-2), form and evolve over time. For M* > 10^8 MSun, LSBGs contribute 47, 7 and 6 per cent of the local number, mass and luminosity densities respectively (~85/11/10 per cent for M* > 10^7 MSun). Today's LSBGs have similar dark-matter fractions and angular momenta to high-surface-brightness galaxies (HSBGs; mu < 23 mag arcsec^-2), but larger effective radii (x2.5 for UDGs) and lower fractions of dense, star-forming gas (more than x6 less in UDGs than HSBGs). LSBGs originate from the same progenitors as HSBGs at z > 2. However, LSBG progenitors form stars more rapidly at early epochs. The higher resultant rate of supernova-energy injection flattens their gas-density profiles, which, in turn, creates shallower stellar profiles that are more susceptible to tidal processes. After z ~ 1, tidal perturbations broaden LSBG stellar distributions and heat their cold gas, creating the diffuse, largely gas-poor LSBGs seen today. In clusters, ram-pressure stripping provides an additional mechanism that assists in gas removal in LSBG progenitors. Our results offer insights into the formation of a galaxy population that is central to a complete understanding of galaxy evolution, and which will be a key topic of research using new and forthcoming deep-wide surveys., Accepted for publication in MNRAS
Published: 2019

48. Characterisation and source identification of biofluorescent aerosol emissions over winter and summer periods in the United Kingdom

Author: Forde, Elisabeth, Gallagher, Martin, Foot, Virginia E., Sarda-Estève, Roland, Crawford, Ian, Kaye, Paul, Topping, D. O., School of Earth and Environmental Sciences [Manchester] (SEES), University of Manchester [Manchester], Defence Science and Technology Laboratory (Dstl), Ministry of Defence (UK) (MOD), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Chimie Atmosphérique Expérimentale (CAE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of Hertfordshire [Hatfield] (UH), School of Earth, Atmospheric and Environmental Sciences [Manchester] (SEAES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment
Abstract: International audience; Primary biological aerosol particles (PBAPs) are an abundant subset of atmospheric aerosol particles which comprise viruses, bacteria, fungal spores, pollen, and fragments such as plant and animal debris. The abundance and diversity of these particles remain poorly constrained, causing significant uncertainties for modelling scenarios and for understanding the potential implications of these particles in different environments. PBAP concentrations were studied at four different sites in the United Kingdom (Weybourne, Davidstow, Capel Dewi, and Chilbolton) using an ultraviolet light-induced fluorescence (UV-LIF) instrument, the Wide-band Integrated Bioaerosol Spectrometer (WIBS), versions 3 and 4. Using hierarchical agglomerative cluster (HAC) analysis, particles were statistically discriminated. Fluorescent particles and clusters were then analysed by comparing to laboratory data of known particle types, assessing their diurnal variation and examining their relationship to the meteorological variables temperature, relative humidity, wind speed, and wind direction. Using local land cover types, sources of the suspected fluorescent particles and clusters were then identified. Most sites exhibited a wet discharged fungal spore dominance , with the exception of one site, Davidstow, which had higher concentrations of bacteria, suggested to result from the presence of a local dairy factory and farm. Differences were identified as to the sources of wet discharged fungal spores, with particles originating from arable and horticultural land at Chilbolton, and improved grassland areas at Weybourne. Total fluorescent particles at Capel Dewi were inferred to comprise two sources, with bacteria originating from the broadleaf and coniferous woodland and wet discharged fungal spores from nearby improved grassland areas, similar to Weybourne. The use of the HAC method and a higher fluorescence threshold (9 standard deviations instead of 3) produced clusters which were considered to be biological following the complete analysis. More published data and information on the reaction of different speciated biological particle types to fluctuations in meteorological conditions, such as relative humidity and temperature, would aid particle type character-isation in studies such as this.
Published: 2019

49. SDN-enabled MIMO Heterogeneous Cooperative Networks with Flexible Cell Association

Author: Symeon Chatzinotas, Pandelis Kourtessis, Marco Di Renzo, Anastasios K. Papazafeiropoulos, John M. Senior, University of Hertfordshire [Hatfield] (UH), University of Luxembourg [Luxembourg], Centre National de la Recherche Scientifique (CNRS), Laboratoire des signaux et systèmes (L2S), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), and Fonds National de la Recherche Luxembourg
Subjects: FOS: Computer and information sciences, Computer science, Computer Science - Information Theory, Distributed computing, MIMO, Context (language use), stochas- tic geometry, 02 engineering and technology, Base station, Telecommunications link, offloading, 0202 electrical engineering, electronic engineering, information engineering, Wireless, [INFO]Computer Science [cs], Electrical and Electronic Engineering, software-defined networking, business.industry, Multi-antenna heterogeneous networks, Applied Mathematics, Information Theory (cs.IT), 020206 networking & telecommunications, small- cell cooperation, Transmitter power output, Computer Science Applications, [INFO.INFO-IT]Computer Science [cs]/Information Theory [cs.IT], business, Software-defined networking, Heterogeneous network
Abstract: Small-cell densification is a strategy enabling the offloading of users from macro base stations (MBSs), in order to alleviate their load and increase the coverage, especially, for cell-edge users. In parallel, as the network increases in density, the BS cooperation emerges as an efficient design method towards the demands for drastic improvement of the system performance against the detrimental overall interference. In addition, the tiers are enhanced with cell association policies by introducing the concept of the association probability. Above this and motivated by the advantages of cooperation among BSs, the small base stations (SBSs) are enriched with this property in their design. SBS cooperation allows shedding light into its impact on the cell selection rules in multi-antenna HetNets. Under these settings, software-defined networking (SDN) is introduced smoothly to play the leading role in the orchestration of the network. {In particular, heavy operations such as the coordination and the cell association are undertaken by virtue of an SDN controller performing and managing efficiently the corresponding computations due to its centralized adaptability and dynamicity towards the enhancement and potential scalability of the network}. In this context, we derive the coverage probability and the mean achievable rate. Not only we show the outperformance of BS cooperation over uncoordinated BSs, but we also demonstrate that the SBS cooperation enables the admittance of more users from the macro-cell BSs (MBSs). Moreover, we investigate the performance of different transmission techniques, and we identify the optimal bias in each case when SBSs cooperate. Finally, we depict that the SBS densification is beneficial until a specific density value since a further increase does not increase the coverage probability., Comment: Accepted in IEEE TWC
Published: 2019
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50. Dust emissivity and absorption cross section in DustPedia late-type galaxies

Author: Laura Magrini, I. De Looze, J. I. Davies, Maarten Baes, Simone Bianchi, Anthony P. Jones, Sébastien Viaene, S. C. Madden, Viviana Casasola, P. De Vis, Emmanuel M. Xilouris, Edvige Corbelli, Maud Galametz, A. Nersesian, Christopher J. R. Clark, Frédéric Galliano, Wouter Dobbels, Aleksandr V. Mosenkov, Nathalie Ysard, INAF - Osservatorio Astrofisico di Arcetri (OAA), Istituto Nazionale di Astrofisica (INAF), Sterrenkundig Observatorium, Universiteit Gent = Ghent University (UGENT), Space Telescope Science Institute (STSci), Cardiff University, University College of London [London] (UCL), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), The Central Astronomical Observatory of the Russian Academy of Sciences [Pulkovo], Russian Academy of Sciences [Moscow] (RAS), National Observatory of Athens (NOA), University of Hertfordshire [Hatfield] (UH), Universiteit Gent, Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010504 meteorology & atmospheric sciences, Metallicity, Milky Way, INFRARED-EMISSION, Extinction (astronomy), DEPLETIONS, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, MASS, 01 natural sciences, galaxies [infrared], infrared: galaxies, 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Cosmic dust, Physics, Luminous infrared galaxy, ISM [galaxies], extinction, SPECTRAL OBSERVATIONS, Absorption cross section, Astronomy and Astrophysics, KAPPA(D), Astrophysics - Astrophysics of Galaxies, Galaxy, galaxies: photometry, Physics and Astronomy, 13. Climate action, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), photometry [galaxies], Cirrus, ABUNDANCE, Astrophysics::Earth and Planetary Astrophysics, dust, COEFFICIENT, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], METALLICITY, galaxies: ISM, INTERSTELLAR DUST
Abstract: Aims: We compare the far-infrared to sub-millimetre dust emission properties measured in high Galactic latitude cirrus with those determined in a sample of 204 late-type DustPedia galaxies. The aim is to verify if it is appropriate to use Milky Way dust properties to derive dust masses in external galaxies. Methods: We used Herschel observations and atomic and molecular gas masses to estimate the disc-averaged dust emissivity at 250 micrometres, and from this, the absorption cross section per H atom and per dust mass. The emissivity requires one assumption, which is the CO-to-H_2 conversion factor, and the dust temperature is additionally required for the absorption cross section per H atom; yet another constraint on the dust-to-hydrogen ratio D/H, depending on metallicity, is required for the absorption cross section dust mass. Results: We find epsilon(250) = 0.82 +/- 0.07 MJy sr^-1 (1E20 H cm^-2)^-1 for galaxies with 4 < F(250)/F(500) < 5. This depends only weakly on the adopted CO-to-H_2 conversion factor. The value is almost the same as that for the Milky Way at the same colour ratio. Instead, for F(250)/F(500) > 6, epsilon(250) is lower than predicted by its dependence on the heating conditions. The reduction suggests a variation in dust emission properties for spirals of earlier type, higher metallicity, and with a higher fraction of molecular gas. When the standard emission properties of Galactic cirrus are used for these galaxies, their dust masses might be underestimated by up to a factor of two. Values for the absorption cross sections at the Milky Way metallicity are also close to those of the cirrus. Mild trends of the absorption cross sections with metallicity are found, although the results depend on the assumptions made., 13 pages, 6 figures, 2 tables, A&A accepted
Published: 2019

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