Author: "University of Catania, Italy" - Searchworks@Jio Institute Digital Library Search Results

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2,347 results on '"University of Catania, Italy"'

1. Stress Echo 2020 - The International Stress Echo Study (SE2020)

Author: Institute of Clinical Physiology, CNR, Pisa,Italy, Salerno Hospital, Italy, Monaldi Hospital, Napoli, Italy, University of Pisa, Italy, San Luca Hospital, Lucca, Italy, Careggi University Hospital, Florence, Italy, Federico II University, San Carlo Public Hospital, Potenza, Italy, Royal Brompton & Harefield NHS Foundation Trust, Ospedale dell'Angelo, Venezia-Mestre, University of Parma, Hospital Clinics, Trieste, Italy, Federal University of Rio Grande do Sul, Hospital San José, Criciuma, Brasil, Hospital San Vicente de Paulo, Passo Fundo, Brasil, University of Belgrade, University of Szeged, Hungary, Elisabeth Hospital, Hodmezovasarhely, Hungary, Sandro Pertini Hospital, Rome, Italy, Hospital Clinics, Bari, Italy, Ospedale Nottola, Siena, Italy, University of Catania, Italy, Medika Cardiocenter, Saint Petersburg, Russian Federation, Acibadem City Clinic Tokuda Hospital, Investigaciones Medicas, Buenos Aires, Argentina, Tomsk National Research Scientific Centre of Russian Academy of Sciences, Tomsk, Russian Federation, Instituto Nacional de Cardiología Mexico City, Mexico, and Hamad Medical Corporation, Heart Hospital -Doha-Qatar
Published: 2021

2. The Neighbourhood Policy of the European Union

Author: Barbara Lippert, Deputy Director of the Institut für Europäische Politik (IEP), Berlin,and lecturer at Humboldt University, Berlin, Germany, Iris Kempe, Senior research fellow, Center for Applied Policy Research, Munich,Germany., Petr Kratochvííl, Deputy Director, Institute of International Relations, Prague, CzechRepublic, Fulvio Attinà, Professor of International Relations and Jean Monnet Chair of EuropeanUnion Politics, University of Catania, Italy, and Cemal Karakas, Peace Research Institute Frankfurt (PRIF), Germany
Published: 2007
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3. Optical properties and conformations of asymmetric polyamides derived from optically active trans -1,2-cyclopropanedicarboxylic acid For a preliminary communication, see Overberger and Shimokawa. 1 This is the 24th in a series of papers concerned with the synthesis and properties of asymmetric polymers; for the previous paper in this series, see Montaudo and Overberger. 2

Author: Department of Chemistry and the Macromolecular Research Center, The University of Michigan, Ann Arbor, Michigan 48109, Institute of Industrial Chemistry, University of Catania, Italy, Overberger, C.G., Shimokawa, Y., Montaudo, G., Department of Chemistry and the Macromolecular Research Center, The University of Michigan, Ann Arbor, Michigan 48109, Institute of Industrial Chemistry, University of Catania, Italy, Overberger, C.G., Shimokawa, Y., and Montaudo, G.
Abstract: Optical properties and conformations, in solution, of optically active polyamides derived from (+)(S)- trans -1,2-cyclopropanedicarboxylic acid with secondary diamines such as trans -2,5-dimethylpiperazine (DMPIP), piperazine (PIP), or N, N???-dimethylethylenediamine (DMED) have been investigated and compared with the corresponding diamide model compounds. The results suggest that the rigid DMPIP and PIP polyamides may exist in ordered conformations in 2,2,2-trifluoroethanol (TFE) and tetramethylene sulfone (TMS), while reversible conformational transitions to highly extended forms may be induced by the addition of methanesulfonic acid (MSA). In MSA/TMS mixtures, a change in the optical properties, and thus possibly in the conformations, can be observed around 0.5 mole fraction of MSA. A study of CD at higher temperature indicates that the conformations of the DMPIP and PIP polymides tend to be randomized on heating in TMS and probably also in MSA. No evidence for salt effects on conformation has been observed. Possible ordered conformations have been proposed.
Published: 2006

4. Definition and clinical variability of SHANK3-related Phelan-McDermid syndrome

Author: Michael Schön, Pablo Lapunzina, Julián Nevado, Teresa Mattina, Cecilia Gunnarsson, Kinga Hadzsiev, Chiara Verpelli, Thomas Bourgeron, Sarah Jesse, Conny M.A. van Ravenswaaij-Arts, Raoul C. Hennekam, General Paediatrics, APH - Quality of Care, Universität Ulm - Ulm University [Ulm, Allemagne], Hospital Universitario La Paz, CIBER de Enfermedades Raras (CIBERER), University of Catania [Italy], Linköping University (LIU), University of Pecs, Istituto di Neuroscienze - Institute of Neuroscience [Milan, Italy] (CNR), Università degli Studi di Milano = University of Milan (UNIMI)-Consiglio Nazionale delle Ricerche [Milano] (CNR), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Deutsches Zentrum für Neurodegenerative Erkrankungen [Ulm] (DZNE), German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), University of Groningen [Groningen], VU University Medical Center [Amsterdam], This study has been supported by the European Reference Network on Rare Congenital Malformations and Rare Intellectual Disability (ERN-ITHACA) represented by Klea Vyshka. Funding was also obtained from the European Union’s Horizon 2020 research and innovation program under the EJP RD COFUND-EJP N° 825575., and This publication has been supported by the European Reference Network on Rare Congenital Malformations and Rare Intellectual Disability (ERN-ITHACA). ERN-ITHACA is partly co-funded by the Health Program of the European Union. We thank for the comprehensive help of Klea Vyshka from ERN-ITHACA. We thank the American guideline consortium for discussions and support.
Subjects: Genotype-phenotype correlation, 22q13 deletion syndrome, Clinical trials, SHANK3, Genetics, Natural history, Phelan-McDermid syndrome, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], PMS, General Medicine, Genetics (clinical)
Abstract: International audience; Phelan-McDermid syndrome (PMS) is an infrequently described syndrome that presents with a disturbed development, neurological and psychiatric characteristics, and sometimes other comorbidities. As part of the development of European medical guidelines we studied the definition, phenotype, genotype-phenotype characteristics, and natural history of the syndrome. The number of confirmed diagnoses of PMS in different European countries was also assessed and it could be concluded that PMS is underdiagnosed. The incidence of PMS in European countries is estimated to be at least 1 in 30,000. Next generation sequencing, including analysis of copy number variations, as first tier in diagnostics of individuals with intellectual disability will likely yield a larger number of individuals with PMS than presently known. A definition of PMS by its phenotype is at the present not possible, and therefore PMS-SHANK3 related is defined by the presence of SHANK3 haploinsufficiency, either by a deletion involving region 22q13.2–33 or a pathogenic/likely pathogenic variant in SHANK3. In summarizing the phenotype, we subdivided it into that of individuals with a 22q13 deletion and that of those with a pathogenic/likely pathogenic SHANK3 variant. The phenotype of individuals with PMS is variable, depending in part on the deletion size or whether only a variant of SHANK3 is present. The core phenotype in the domains development, neurology, and senses are similar in those with deletions and SHANK3 variants, but individuals with a SHANK3 variant more often are reported to have behavioural disorders and less often urogenital malformations and lymphedema. The behavioural disorders may, however, be a less outstanding feature in individuals with deletions accompanied by more severe intellectual disability. Data available on the natural history are limited. Results of clinical trials using IGF-1, intranasal insulin, and oxytocin are available, other trials are in progress. The present guidelines for PMS aim at offering tools to caregivers and families to provide optimal care to individuals with PMS.
Published: 2023
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5. Équilibres, stabilité et sensibilité d'un système robotique de manipulation aérienne soumis à incertitudes des paramètres

Author: Gabellieri, Chiara, Tognon, Marco, Sanalitro, Dario, Franchi, Antonio, Robotics and Mechatronics, University of Twente, Institut National de Recherche en Informatique et en Automatique (Inria), University of Catania [Italy], Laboratoire d'analyse et d'architecture des systèmes (LAAS), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), and Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)
Subjects: Cooperative Aerial Manipulation Aerial Systems: Mechanics and Control Motion Control, Motion Control, FOS: Electrical engineering, electronic engineering, information engineering, [INFO.INFO-RB]Computer Science [cs]/Robotics [cs.RO], Systems and Control (eess.SY), Cooperative Aerial Manipulation, Electrical Engineering and Systems Science - Systems and Control, Aerial Systems: Mechanics and Control
Abstract: This work studies how parametric uncertainties affect the cooperative manipulation of a cable-suspended beam-shaped load by means of two aerial robots not explicitly communicating with each other. In particular, the work sheds light on the impact of the uncertain knowledge of the model parameters available to an established communication-less force-based controller. First, we find the closed-loop equilibrium configurations in the presence of the aforementioned uncertainties, and then we study their stability. Hence, we show the fundamental role played in the robustness of the load attitude control by the internal force induced in the manipulated object by non-vertical cables. Furthermore, we formally study the sensitivity of the attitude error to such parametric variations, and we provide a method to act on the load position error in the presence of the uncertainties. Eventually, we validate the results through an extensive set of numerical tests in a realistic simulation environment including underactuated aerial vehicles and sagging-prone cables, and through hardware experiments.
Published: 2023

6. A new recycling technique for the waste tires reuse

Author: Ferrante, Margherita [Environmental and Food Hygiene Laboratories (LIAA), Department of Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania (Italy)]
Published: 2017
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7. Le niveau de biodiversité végétale des prairies modifie les processus digestifs, le microbiote ruminal et des fèces des vaches laitières et la composition du lait

Author: Musati, M., Coppa, M., Delbès, Céline, Verdier-Metz, Isabelle, Popova, Milka, Niderkorn, Vincent, Bouchon, Matthieu, Farizon, Yves, F., Enjalbert, M, Renna, C, Lussiana, Natalello, Antonino, Martin, Bruno, Ferlay, Anne, Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Catania [Italy], Unité Mixte de Recherche sur le Fromage (UMRF), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Unité Expérimentale Systèmes d'Elevage de Ruminants de Moyenne Montagne (Herbipôle), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Tissus animaux, nutrition, digestion, écosystème et métabolisme (TANDEM), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT), Università degli studi di Torino = University of Turin (UNITO), INRAE, and Institut de l'Elevage
Subjects: [SDV]Life Sciences [q-bio]
Abstract: Séance : Alimentation; International audience; To study the interactions between the plant biodiversity of pastures, ruminants, their microbiota and their products, an in vivo and in vitro experiment was carried out in the spring 2018. After a 5-week adaptation period on a common plot, 2 groups of 7 dairy cows were led for 4 weeks on 2 plots with contrasting levels of plant biodiversity: LD (19 species, mainly grasses) and HD (56 species, mostly dicots). Samples of grass selected by the cows (simulated bites), rumen fluid, faeces, and milk were taken at the end of the experimental periods, respectively. Milk production and protein and fat concentration were similar between treatments. The grass from group HD was more fibrous and had a higher total tannin content. Grass total fatty acids (FA) and C18:3 n-3 contents were higher for LD. Total gas production during in vitro ruminal fermentation of HD grass was lower compared to LD, this being probably due to the inhibition of bacterial proliferation by tannins, which also protected the digestion of the dry matter of the HD group compared to LD. Ruminal fluid of HD cows differed from that of LD cows by a lower concentration of total FA but a higher proportion of polyunsaturated fatty acids (PUFA). This suggests a less complete biohydrogenation of dietary PUFA induced by tannins. The β-diversity, which considers the equipartition of species, showed differences between the bacterial and fungal communities of the ruminal liquid and the faeces of the cows between the 2 treatments. The FA profile of milk from LD cows is distinguished by a higher concentration of C18:2 c9t11. Moreover, the quantity of C18:3 n-3 is not significantly different between the treatments, despite the marked differences on grass. The lower total FA and n-3 content of the grass from the HD group could have been compensated by the protective role of tannins in the rumen.; Pour étudier les interactions entre la biodiversité végétale des prairies, les ruminants, leur microbiote et leurs produits, des expérimentations in vivo et in vitro ont été menées au printemps 2018. Après une période d’adaptation de 5 semaines sur une parcelle commune, 2 lots de 7 vaches laitières ont été conduits pendant 4 semaines sur 2 parcelles présentant des niveaux de biodiversité végétale contrastés : LD (diversité flaible,19 espèces, beaucoup des graminées) et HD (diversité élevée 56 espèces, beaucoup des dicotylédones). Des prélèvements d’herbe sélectionnés par les vaches (bouchées simulées), de liquide ruminal, de fèces et de lait ont été réalisés en fin de période d’adaptation, et en fin de période expérimentale. La production laitière et les taux protéique et butyreux était similaires entre les lots. L'herbe du lot HD était plus fibreuse et avait une teneur en tanins totaux plus élevée. La teneur en acides gras (AG) totaux de l’herbe, et en C18:3 n3, était plus élevée pour LD. La production totale de gaz lors de la fermentation ruminale in vitro de l’herbe HD était plus faible par rapport à LD, ceci étant probablement dû à l’inhibition de l’activité bactérienne par les tanins, qui ont également protégé la digestion de la matière sèche (MS) du lot HD par rapport au lot LD. Le liquide ruminal des vaches HD a présenté une concentration plus faible en AG totaux mais une proportion plus élevée en acides gras polyinsaturés (AGPI). Cela suggère une biohydrogénation moins complète des AGPI alimentaires induite par les tanins. La β-diversité, qui considère l’équipartition des espèces, a montré des différences entre des communautés bactériennes et fongiques du liquide ruminal et des fèces des vaches entre les 2 lots. Le profil en AG du lait des vaches LD se distingue par une concentration plus importante en C18:2 c9t11. Par contre, la quantité de C18:3 n-3 n’est pas significativement différente entre les lots, malgré les différences marquées sur l’herbe. Le contenu en AG totaux et en n-3 plus faible de l’herbe du lot HD, pourrait avoir été compensé par l’effet protecteur des tanins dans le rumen.
Published: 2022

8. Invasiveness, biology, ecology, and management of the fall armyworm, Spodoptera frugiperda

Author: Kenis, Marc, Benelli, Giovanni, Biondi, Antonio, Calatayud, Paul-André, Day, Roger, Desneux, Nicolas, Harrison, Rhett, Kriticos, Darren, Rwomushana, Ivan, van den Berg, Johnnie, Verheggen, François, Zhang, Yong-Jun, Agboyi, Lakpo Koku, Ahissou, Régis Besmer, Ba, Malick, Bernal, Julio, Nègre, Nicolas, CABI DELEMONT CHE, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), University of Pisa - Università di Pisa, University of Catania [Italy], Evolution, génomes, comportement et écologie (EGCE), Institut de Recherche pour le Développement (IRD)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre for Agricultural and Biosciences International (CABI), Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), Center for International Forestry Research (CIFOR), Consultative Group on International Agricultural Research [CGIAR] (CGIAR), CSIRO Entomology, Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), North-West University [South Aftrica] (NWU), Université de Liège, Chinese Academy of Agricultural Sciences (CAAS), cabi, Université Polytechnique Nazi Boni Bobo-Dioulasso (UNB), International Crops Research Institute for the Semi-Arid Tropics [Niger] (ICRISAT), International Crops Research Institute for the Semi-Arid Tropics [Inde] (ICRISAT), Consultative Group on International Agricultural Research [CGIAR] (CGIAR)-Consultative Group on International Agricultural Research [CGIAR] (CGIAR), Université du Texas, Diversité, Génomes & Interactions Microorganismes - Insectes [Montpellier] (DGIMI), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Montpellier (UM), Foreign, Commonwealth and Development Office (FCDO) , UK, Netherlands Government, European Commission Directorate-General for International Cooperation and Development (DEVCO), Swiss Agency for Development and Cooperation (SDC) through the Plantwise+ programme, and Ministry of Agriculture, Czech Republic MZE-RO0418
Subjects: biopesticides, integrated pest management, Insect Science, Noctuidae, [SDV]Life Sciences [q-bio], genomics, biological control, globalization, invasive species
Abstract: Early access; International audience; The fall armyworm (FAW), Spodoptera frugiperda (JE Smith, 1797), is a serious pest of several crops, particularly maize and other cereals. It has long been known as a pest in the Americas and has invaded most of Africa and parts of the Middle East, Asia, and Australia in the last six years. Its new status as an invasive species causing serious damage in many regions worldwide has highlighted the need for better understanding and has generated much research. In this article, we provide a comprehensive review of FAW covering its (i) taxonomy, biology, ecology, genomics, and microbiome, (ii) worldwide status and geographic spread, (iii) potential for geographic expansion and quarantine measures in place, and (iv) management including monitoring, sampling, forecasting, biological control, biopesticides, agroecological strategies, chemical control, insecticide resistance, effects of insecticides on natural enemies, as well as conventional and transgenic resistant cultivars. We conclude with recommendations for research to enhance the sustainable management of FAW in invaded regions.
Published: 2022
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9. ScenaLand: a simple methodology for developing land use and management scenarios

Author: Amandine Valérie Pastor, Joao Pedro Nunes, Rossano Ciampalini, Haithem Bahri, Mohamed Annabi, Mohamed Chikhaoui, Armand Crabit, Stéphane Follain, Jan Jacob Keizer, Jérôme Latron, Feliciana Licciardello, Laurène Marien, Insaf Mekki, Mariano Moreno de las Heras, Antonio J. Molina, Mustapha Naimi, Mohamed Sabir, Sandra Valente, Damien Raclot, Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Technologies et Méthodes pour les Agricultures de demain (UMR ITAP), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Centre for Ecology - Evolution and Environmental Changes (cE3c), Universidade de Lisboa = University of Lisbon (ULISBOA), Wageningen University and Research [Wageningen] (WUR), Università degli Studi di Firenze = University of Florence (UniFI), Université de Carthage - University of Carthage, Institut Agronomique et Vétérinaire Hassan II (IAV Hassan II), Gestion de l'Eau, Acteurs, Usages (UMR G-EAU), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut de Recherche pour le Développement (IRD)-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Agroécologie [Dijon], Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon, University of Aveiro, Institute of Environmental Assessment and Water Research (IDAEA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), University of Catania [Italy], University King Juan Carlos [Madrid], University of Barcelona, Polytechnical University of Valencia, Ecole Nationale Forestière d'Ingénieurs du Maroc [Salé] (ENFI), Centre for Environmental and Marine Studies [Aveiro] (CESAM), Universidade de Aveiro, and Repositório da Universidade de Lisboa
Subjects: Soil Physics and Land Management, Land use and management scenarios, Global and Planetary Change, Narrative, Ecology, Soil and water conservation techniques, Life Science, Water Systems and Global Change, Land degradation, Bodemfysica en Landbeheer, [SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study, Experts
Abstract: Scenarios serve science by testing the sensitivity of a system and/or society to adapt to the future. In this study, we present a new land use scenario methodology called ScenaLand. This methodology aims to develop plausible and contrasting land use and management (LUM) scenarios, useful to explore how LUM (e.g. soil and water conservation techniques) may affect ecosystem services under global change in a wide range of environments. ScenaLand is a method for constructing narrative and spatially explicit land use scenarios that are useful for end-users and impact modellers. This method is innovative because it merges literature and expert knowledge, and its low data requirement makes it easy to be implemented in the context of inter-site comparison, including global change projections. ScenaLand was developed and tested on six different Mediterranean agroecological and socioeconomic contexts during the MASCC research project (Mediterranean agricultural soil conservation under global change). The method first highlights the socioeconomic trends of each study site including emerging trends such as new government laws, LUM techniques through a qualitative survey addressed to local experts. Then, the method includes a ranking of driving factors, a matrix about land use evolution, and soil and water conservation techniques. ScenaLand also includes a framework to develop narratives along with two priority axes (contextualized to environmental protection vs. land productivity in this study). In the context of this research project, four contrasting scenarios are proposed: S1 (business-as-usual), S2 (market-oriented), S3 (environmental protection), and S4 (sustainable). Land use maps are then built with the creation of LUM allocation rules based on agroecological zoning. ScenaLand resulted in a robust and easy method to apply with the creation of 24 contrasted scenarios. These scenarios come not only with narratives but also with spatially explicit maps that are potentially used by impact modellers and other end-users. The last part of our study discusses the way the method can be implemented including a comparison between sites and the possibilities to implement ScenaLand in other contexts., This work and the postdoctoral grant of AV Pastor benefits from the financial support of the MASCC project through ARIMNET2, an ERA-NET funded by the European Union’s Seventh Framework Program for research, technological development and demonstration under grant agreement no. 618127. In addition, MMH is beneficiary of a Serra Hunter fellowship (UB-LE-9055) funded by the Generalitat de Catalunya. JJK received the financial support through CESAM (UIDP/50017/2020 + UIDB/50017/2020 + LA/P/0094/2020), from FCT/MCTES through national funds (OE). The authors would like to thank Marie Castellazi for her valuable contribution and shared experience in building land use scenarios, Dominique Rollain for his valuable contribution to the Roujan scenarios and Francesc Gallart for his valuable contribution to the Can Vila study case. We would like to thank all the other persons that contributed to the related surveys. Finally, we would like to send our homage to Dr Yves Le- Bissonnais, a brilliant researcher in the erosion discipline and coauthor of this research article who passed away in 2021.
Published: 2022
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10. How Geography and Climate Shaped the Genomic Diversity of Italian Local Cattle and Sheep Breeds

Author: Gabriele Senczuk, Andrea Criscione, Salvatore Mastrangelo, Filippo Biscarini, Donata Marletta, Fabio Pilla, Denis Laloë, Roberta Ciampolini, Università degli Studi del Molise = University of Molise (UNIMOL), University of Catania [Italy], Università degli studi di Palermo - University of Palermo, Istituto di Biologia e Biotecnologia Agraria, National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Génétique Animale et Biologie Intégrative (GABI), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Pisa - Università di Pisa, European Project: 817580,GenRes Bridge, Senczuk G., Criscione A., Mastrangelo S., Biscarini F., Marletta D., Pilla F., Laloe D., and Ciampolini R.
Subjects: sheep, General Veterinary, redundancy analysis, cilmate, geography, Settore AGR/17 - Zootecnica Generale E Miglioramento Genetico, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, cattle, redundancy analysi, Animal Science and Zoology, genome, climate
Abstract: International audience; Understanding the relationships among geography, climate, and genetics is increasingly important for animal farming and breeding. In this study, we examine these inter-relationships in the context of local cattle and sheep breeds distributed along the Italian territory. To this aim, we used redundancy analysis on genomic data from previous projects combined with geographical coordinates and corresponding climatic data. The effect of geographic factors (latitude and longitude) was more important in sheep (26.4%) than that in cattle (13.8%). Once geography had been partialled out of analysis, 10.1% of cattle genomic diversity and 13.3% of that of sheep could be ascribed to climatic effects. Stronger geographic effects in sheep can be related to a combination of higher pre-domestication genetic variability together with biological and productive specificities. Climate alone seems to have had less impact on current genetic diversity in both species, even if climate and geography are greatly confounded. Results confirm that both species are the result of complex evolutionary histories triggered by interactions between human needs and environmental conditions.
Published: 2022
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11. A new regularity criterion of weak solutions to the 3D micropolar fluid flows in terms of the pressure

Author: Maria Alessandra Ragusa, Michel Théra, Sadek Gala, Thera, Michel, University of Mostaganem, Mostaganem, Algeria, University of Catania [Italy], Université de Limoges (UNILIM), and Federation University Australia Ballarat
Subjects: General Mathematics, 010102 general mathematics, Mathematical analysis, Regularity, three-dimensional micropolar fluid flows. pressure field, [MATH.MATH-OC] Mathematics [math]/Optimization and Control [math.OC], 01 natural sciences, Pressure field, Regularity, Physics::Fluid Dynamics, three-dimensional micropolar fluid flows. pressure field, [MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP], [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], [MATH.MATH-AP] Mathematics [math]/Analysis of PDEs [math.AP], 0101 mathematics, Mathematics
Abstract: This note aims to giving a new regularity criterion for weak solutions to the three-dimensional micropolar fluid flows by imposing a critical growth condition on the field of pressure. Keywords Micropolar fluid flows; · weak solutions; · Pressure criterion · Besov spaces.. Mathematics Subject Classification (2000) 35Q35 · 35B65 · 76D05 In this note we consider the following Cauchy problem (1) for the incompressible micropolar fluid equations in R 3 : ∂ t u − ∆ u + (u · ∇) u + ∇π − ∇ × ω = 0, (1a) ∂ t ω − ∆ ω − ∇∇ · ω + 2ω + (u · ∇)ω − ∇ × u = 0, (1b) ∇ · u = 0, (1c) u(x, 0) = u 0 (x), ω(x, 0) = ω 0 (x), (1d) where u = u(x,t) ∈ R 3 , ω = ω(x,t) ∈ R 3 and π = π (x,t) denote the unknown velocity of the fluid, the micro-rotational velocity of the fluid particles and the unknown scalar pressure of the fluid at the point (x,t) ∈ R 3 × (0, T), respectively, while u 0 , ω 0 are given initial data satisfying ∇ · u = 0 in the sense of distributions. This model for micropolar fluid flows proposed by Eringen [6] enables to consider some physical phenomena that cannot be treated by the classical Navier-Stokes equations for the viscous incompressible fluids, such as for example, the motion of animal blood, muddy fluids, liquid crystals and dilute aqueous polymer solutions, colloidal suspensions, etc. When the micro-rotation effects are neglected or ω = 0, (1) reduces to the in-compressible Navier-Stokes equations, and it is well known that regularity criteria
Published: 2020
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12. On‐line monitoring of extreme values of geometric profiles in finite horizon processes

Author: Philippe Castagliola, Giovanni Celano, University of Catania [Italy], Systèmes Logistiques et de Production (SLP ), Laboratoire des Sciences du Numérique de Nantes (LS2N), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Université de Nantes (UN)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)
Subjects: 0209 industrial biotechnology, Computer science, control chart, generalized extreme value distribution, random Gaussian process, statistical performance, Geometry, control chart, 02 engineering and technology, Finite horizon, statistical performance, Management Science and Operations Research, 01 natural sciences, generalized extreme value distribution, [STAT]Statistics [stat], 010104 statistics & probability, 020901 industrial engineering & automation, random Gaussian process, 0101 mathematics, Line (text file), Safety, Risk, Reliability and Quality, Extreme value theory, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020
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13. Impact of global changes on soil erosion in an Italian basin of mixed pastures (Sicily)

Author: Laurène Marien, Rossano Ciampalini, Feliciana Licciardello, Emanuela Rita Giuffrida, Amandine Valérie Pastor, Frederic Huard, Damien Raclot, Gestion de l'Eau, Acteurs, Usages (UMR G-EAU), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Bureau de Recherches Géologiques et Minières (BRGM) (BRGM)-Institut de Recherche pour le Développement (IRD)-AgroParisTech-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Florence, Università degli Studi di Firenze = University of Florence (UniFI), Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, University of Catania [Italy], Technologies et Méthodes pour les Agricultures de demain (UMR ITAP), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, ELSA RESEARCH GROUP FOR ENVIRONMENTAL LIFECYCLE AND SUSTAINABILITY ASSESSMENT MONTPELLIER FRA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Direction Responsabilité Sociétale et Environnementale (UAR DRSE), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: modelling, pasture, [SDE]Environmental Sciences, land use, agricultural practices, erosion, Global change, climate
Abstract: Soil is an essential natural resource, non-renewable on a human time scale, which is degraded mainly by water erosion, especially in the Mediterranean context. Erosion can cause significant soil losses at the plot and catchment level through the transfer of sediments which, in a framework of global changes (climate and land use), may severely increase in intensity.This study was part of the MASCC/Arimnet2 project, which aimed to assess the vulnerability of Mediterranean agricultural soils to global changes and contribute to the definition of sustainable agricultural conservation strategies for Mediterranean agro-ecosystems. In the challenge of reconciling agricultural production, environmental protection and the effects of climate change, we believe that some trade-offs are possible.We assessed the impact of global change scenarios on soil loss in a mixed pasture watershed in the Cannata basin (Sicily) by 2050, testing strategies to maintain agricultural production and protect soil resources. With the LANDSOIL model, we simulated soil erosion on different climatic (RCP4.5) and land use scenarios derived from a combination of plausible socio-economic conditions. The land use scenarios have been designed according two principal axes: agricultural production and soil conservation. All scenarios tend towards an increase in crops (wheat and orchard) over different degrees represented by the productivity axis. We also adopted a main differentiation between intensive and extensive practices for pasture, and between conventional and conservative practices for wheat and orchard. The simulation results show that climate change can lead to a decrease in erosion. The evolution of erosion is also strongly influenced by land use. Environmental protection and sustainability scenarios limit soil erosion compared to the most productive scenarios which, on the contrary, may result in an increase. Reducing intensive grazing in favor of conservation wheat and arboriculture, increases the cultivated area and can decrease soil erosion by 2050 horizon. The use of a suitable land use scenarios can contribute to environmental protection, sustainability, and provide levers to meet food production requirements. Key wordsGlobal change, climate, erosion, land use, modelling, agricultural practices, pasture.
Published: 2022
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14. ESC guidance for the diagnosis and management of cardiovascular disease during the COVID-19 pandemic: part 1—epidemiology, pathophysiology, and diagnosis

Author: Baigent, Colin, Windecker, Stephan, Andreini, Daniele, Arbelo, Elena, Barbato, Emanuele, Bartorelli, Antonio, Baumbach, Andreas, Behr, Elijah, Berti, Sergio, Bueno, Héctor, Capodanno, Davide, Cappato, Riccardo, Chieffo, Alaide, Collet, Jean-Philippe, Cuisset, Thomas, de Simone, Giovanni, Delgado, Victoria, Dendale, Paul, Dudek, Dariusz, Edvardsen, Thor, Elvan, Arif, González-Juanatey, José, Gori, Mauro, Grobbee, Diederick, Guzik, Tomasz, Halvorsen, Sigrun, Haude, Michael, Heidbuchel, Hein, Hindricks, Gerhard, Ibanez, Borja, Karam, Nicole, Katus, Hugo, Klok, Fredrikus, Konstantinides, Stavros, Landmesser, Ulf, Leclercq, Christophe, Leonardi, Sergio, Lettino, Maddalena, Marenzi, Giancarlo, Mauri, Josepa, Metra, Marco, Morici, Nuccia, Mueller, Christian, Petronio, Anna Sonia, Polovina, Marija, Potpara, Tatjana, Praz, Fabien, Prendergast, Bernard, Prescott, Eva, Price, Susanna, Pruszczyk, Piotr, Rodríguez-Leor, Oriol, Roffi, Marco, Romaguera, Rafael, Rosenkranz, Stephan, Sarkozy, Andrea, Scherrenberg, Martijn, Seferovic, Petar, Senni, Michele, Spera, Francesco, Stefanini, Giulio, Thiele, Holger, Tomasoni, Daniela, Torracca, Lucia, Touyz, Rhian, Wilde, Arthur, Williams, Bryan, Bern University Hospital [Berne] (Inselspital), Centro Cardiologico Monzino [Milano], Dpt di Scienze Cliniche e di Comunità [Milano] (DISCCO), Università degli Studi di Milano = University of Milan (UNIMI)-Università degli Studi di Milano = University of Milan (UNIMI)-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), 'Federico II' University of Naples Medical School, St George's, University of London, Fondazione Toscana Gabriele Monasterio, Hospital Universitario 12 de Octubre [Madrid], Centro Nacional de Investigaciones Cardiovasculares Carlos III [Madrid, Spain] (CNIC), Instituto de Salud Carlos III [Madrid] (ISC), University of Catania [Italy], IRCCS San Raffaele Scientific Institute [Milan, Italie], Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital de la Timone [CHU - APHM] (TIMONE), Leiden University Medical Center (LUMC), Universiteit Leiden, Hasselt University (UHasselt), Jessa Ziekenhuis [Hasselt], Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Oslo University Hospital [Oslo], Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Pontchaillou [Rennes], Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), University College of London [London] (UCL), Università degli Studi di Milano [Milano] (UNIMI)-Università degli Studi di Milano [Milano] (UNIMI)-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [IHU ICAN], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Myocarditis, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV]Life Sciences [q-bio], Pulmonary embolism, ACE2, COVID-19, Heart failure, Thrombosis, Acute coronary syndromes, Arrhythmias, Cardiogenic shock, Biomarkers, Venous thromboembolism
Abstract: International audience; Aims - Since its emergence in early 2020, the novel severe acute respiratory syndrome coronavirus 2 causing coronavirus disease 2019 (COVID-19) has reached pandemic levels, and there have been repeated outbreaks across the globe. The aim of this two-part series is to provide practical knowledge and guidance to aid clinicians in the diagnosis and management of cardiovascular disease (CVD) in association with COVID-19. Methods and results - A narrative literature review of the available evidence has been performed, and the resulting information has been organized into two parts. The first, reported here, focuses on the epidemiology, pathophysiology, and diagnosis of cardiovascular (CV) conditions that may be manifest in patients with COVID-19. The second part, which will follow in a later edition of the journal, addresses the topics of care pathways, treatment, and follow-up of CV conditions in patients with COVID-19. Conclusion - This comprehensive review is not a formal guideline but rather a document that provides a summary of current knowledge and guidance to practicing clinicians managing patients with CVD and COVID-19. The recommendations are mainly the result of observations and personal experience from healthcare providers. Therefore, the information provided here may be subject to change with increasing knowledge, evidence from prospective studies, and changes in the pandemic. Likewise, the guidance provided in the document should not interfere with recommendations provided by local and national healthcare authorities.
Published: 2022
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15. A number‐between‐events control chart for monitoring finite horizon production processes

Author: Nataliya Chukhrova, Philippe CASTAGLIOLA, Giovanni Celano, Arne Johannssen, University of Hamburg, University of Catania [Italy], Conception, Pilotage, Surveillance et Supervision des systèmes (LS2N - équipe CPS3), Laboratoire des Sciences du Numérique de Nantes (LS2N), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), and Nantes Université (Nantes Univ)
Subjects: [STAT]Statistics [stat], finite horizon processes, nite horizon processes, fraction nonconforming, negative hypergeometric control chart, statistical process monitoring, Management Science and Operations Research, control charts, Safety, Risk, Reliability and Quality, control charts, finite horizon processes, fraction nonconforming, negative hypergeometric control chart, number-between-events, statistical process monitoring, number-between-events
Abstract: International audience; In this paper, we present a number-between-events (NBE) control chart for monitoring the fraction nonconforming in nite horizon production (FHP) processes and related specic performance measures. When monitoring fractions nonconforming in FHP processes, the common binomial p-chart has two crucial limitations: the underlying distributional assumptions are violated when dealing with low-volume production and a scarce eciency in the case of processes characterized by a low fraction nonconforming. Thus, an ecient monitoring of FHP processes requires the selection of the correct underlying statistical model: in this case, a distribution from the hypergeometric family of discrete statistical distributions. An ecient statistical monitoring of processes with low fractions nonconforming can be achieved by means of discrete time-between-events (TBE) control charts, which count the number of units up to the appearance of a xed number of nonconforming units in the sample. Here, we present a discrete TBE-chart, denoted as NBE-chart, based on the negative hypergeometric distribution that meets numerous requirements of ecient monitoring of FHP processes. The proposed control chart can be conveniently used for both low-volume and mass production in processes with frequent changeovers.
Published: 2022
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16. A novel approach to β-decay: PANDORA, a new experimental setup for future in-plasma measurements

Author: David Mascali, Domenico Santonocito, Simone Amaducci, Lucio Andò, Vincenzo Antonuccio, Sándor Biri, Alfio Bonanno, Vincenza Piera Bonanno, Stefan Briefi, Maurizio Busso, Luigi Celona, Luigi Cosentino, Sergio Cristallo, Marco Cuffiani, Costantino De Angelis, Giacomo De Angelis, Davide De Salvador, Loreto Di Donato, Jean-Eric Ducret, Aref Eshkevar Vakili, Ursel Fantz, Alessio Galatà, Carmelo Sebastiano Gallo, Santo Gammino, Tommaso Isernia, Hannu Koivisto, Karl-Ludwig Kratz, Risto Kronholm, Marco La Cognata, Silvia Leoni, Andrea Locatelli, Mario Maggiore, Fabio Maimone, Luciana Malferrari, Giorgio Mancini, Laurent Maunoury, Giorgio Sebastiano Mauro, Maria Mazzaglia, Alberto Mengoni, Andrea Miraglia, Bharat Mishra, Mario Musumeci, Daniel Ricardo Napoli, Eugenia Naselli, Fabrizio Odorici, Libero Palladino, Giuseppe Palmisano, Santi Pavone, Salvatore Pennisi, Albino Perego, Angelo Pidatella, Richard Rácz, Riccardo Reitano, Danilo Rifuggiato, Matteo Rinaldi, Antonio Domenico Russo, Filippo Russo, Gaetano Schillaci, Stefano Selleri, Stefano Simonucci, Gino Sorbello, Roberta Spartà, Simone Taioli, Klaus Tinschert, Giuseppe Torrisi, Antonio Trifirò, Sedina Tsikata, Aurora Tumino, Diego Vescovi, Luca Vincetti, ITA, Istituto Nazionale di Fisica Nucleare, Sezione di Catania (INFN), Università degli studi di Catania = University of Catania (Unict), INAF - Osservatorio Astrofisico di Catania (OACT), Istituto Nazionale di Astrofisica (INAF), Institute for Nuclear Research [Budapest] (ATOMKI), Hungarian Academy of Sciences (MTA), Max Planck Institute for Plasma physics (IPP-MPG), Max-Planck-Gesellschaft, Department of Physics and Geology [Perugia], Università degli Studi di Perugia = University of Perugia (UNIPG), Istituto Nazionale di Fisica Nucleare, Sezione di Perugia (INFN, Sezione di Perugia), Istituto Nazionale di Fisica Nucleare (INFN), Istituto Nazionale di Fisica Nucleare, Sezione di Bologna (INFN, Sezione di Bologna), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Università degli Studi di Padova = University of Padua (Unipd), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), University of Jyväskylä (JYU), Institute for Nuclear Chemistry, University of Mainz, GSI Helmholtzzentrum für Schwerionenforschung (GSI), Università degli Studi di Camerino = University of Camerino (UNICAM), University of L'Aquila [Italy] (UNIVAQ), University of Catania [Italy], University of Trento [Trento], Università degli Studi di Pavia = University of Pavia (UNIPV), Laboratori Nazionali di Legnaro (LNL), Università degli studi di Parma = University of Parma (UNIPR), Trento Institute for Fundamental Physics and Applications, Italy, Department of Mathematical and Computer Science, Physical Sciences and Earth Sciences (MIFT), Università degli Studi di Messina = University of Messina (UniMe), Institut de Combustion, Aérothermique, Réactivité et Environnement (ICARE), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Institut des Sciences de l'Ingénierie et des Systèmes (INSIS - CNRS), and Goethe-University Frankfurt am Main
Subjects: plasma diagnostics, astrofysiikka, Plasma trap, General Physics and Astronomy, nucleosynthesis, Beta decay, plasmatekniikka, plasmafysiikka, Plasma diagnostics, ilmaisimet, beta decay, plasma trap, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], ydinfysiikka, Nucleosynthesis
Abstract: International audience; Theoretical predictions as well as experiments performed at storage rings have shown that the lifetimes of β-radionuclides can change significantly as a function of the ionization state. In this paper we describe an innovative approach, based on the use of a compact plasma trap to emulate selected stellar-like conditions. It has been proposed within the PANDORA project (Plasmas for Astrophysics, Nuclear Decay Observation and Radiation for Archaeometry) with the aim to measure, for the first time in plasma, nuclear β-decay rates of radionuclides involved in nuclear-astrophysics processes. To achieve this task, a compact magnetic plasma trap has been designed to reach the needed plasma densities, temperatures, and charge-states distributions. A multi-diagnostic setup will monitor, on-line, the plasma parameters, which will be correlated with the decay rate of the radionuclides. The latter will be measured through the detection of the γ-rays emitted by the excited daughter nuclei following the β-decay. An array of 14 HPGe detectors placed around the trap will be used to detect the emitted γ-rays. For the first experimental campaign three isotopes, 176Lu, 134Cs, and 94Nb, were selected as possible physics cases. The newly designed plasma trap will also represent a tool of choice to measure the plasma opacities in a broad spectrum of plasma conditions, experimentally poorly known but that have a great impact on the energy transport and spectroscopic observations of many astrophysical objects. Status and perspectives of the project will be highlighted in the paper.
Published: 2022
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17. Laser scanner data processing and 3D modeling using a free and open source software

Author: Salvatore, Zito [Dept. of Civil Engineering and Architecture, University of Catania (Italy)]
Published: 2015
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18. Epidemiology of Primary Brain Tumors in the Province of Catania during the 2003-2016 Period

Author: Alessandra Nicoletti, Chaima Chebil, Margherita Ferrante, Farid Boumediene, Antonietta Torrisi, Pierre-Marie Preux, Calogero Edoardo Cicero, Mario Zappia, Antonella Ippolito, Salvatore Sciacca, Alessia Di Prima, Cristina Rascunà, Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Catania [Italy], IOM Ricerca Srl [Catania, Italy], Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
Subjects: Male, medicine.medical_specialty, Epidemiology, 030501 epidemiology, Meningioma, Central Nervous System Neoplasms, 03 medical and health sciences, Primary brain tumors, 0302 clinical medicine, Internal medicine, medicine, Meningeal Neoplasms, Humans, Registries, Survival rate, Survival analysis, business.industry, Brain Neoplasms, Incidence (epidemiology), Incidence, Cancer registry, medicine.disease, Province of Catania, Confidence interval, 3. Good health, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), 0305 other medical science, business, 030217 neurology & neurosurgery, International Classification of Diseases for Oncology
Abstract: Introduction: Primary brain tumors (PBTs) account for approximately 2% of all cancers and are associated with significant morbidity and mortality. However, only few epidemiological studies focus on PBTs in Italy. The aim of this study was to evaluate incidence, temporal trend, and survival rate of all PBTs in the province of Catania during the study period. Methods: All patients diagnosed with PBTs in the province of Catania during the 2003-2016 were identified through the local cancer registry. All cases were classified by histology according to 2007 WHO classification of central nervous system tumors, using the International Classification of Diseases for Oncology, 3rd edition codes. The incidence rate (IR) was calculated for all PBTs and by gender, histology, age-groups, and behavior. Trend analysis was performed using a piecewise log-linear model. Results: A total of 3,819 cases were identified with a female/male ratio of 1.45. The IR for all PBTs was 25.3/100,000 person-years (95% confidence interval 24.5–26.1). Most PBTs were nonmalignant (59.5%, IR = 15.0) with a female predominance. Conversely, malignant tumors (32.4%, IR = 8.2) were more common among men, with a female/male ratio of 0.9. The most frequently reported histology was meningioma (39.0%, IR = 9.8), followed by glioblastoma (11.6%, IR = 2.9). A peak of incidence was found in the 75–84 years age-group, with an IR of 77.6/100,000 person-years. Overall, no increase in incidence was observed along the study period. Conclusions: The IR of PBTs in the province of Catania is close to incidence reported worldwide. Further studies on risk factors are necessary.
Published: 2021
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19. Symmetry-breaking transitions in the early steps of protein self-assembly

Author: Giuseppe Compagnini, Antonio Raudino, Martina Pannuzzo, Carmelo La Rosa, Danilo Milardi, Franca Fraternali, Fabio Lolicato, Birgit Strodel, Human Rezaei, Francesca Collu, Marcello Condorelli, Trang Nhu Do, Ayyalusamy Ramamoorthy, Mikko Karttunen, University of Catania [Italy], Department of Physics [Helsinki], Falculty of Science [Helsinki], University of Helsinki-University of Helsinki, Biochemistry Center Heidelberg (BZH), CNR – Istituto di Biostrutture e Bioimmagini, University of Waterloo [Waterloo], University of Western Ontario (UWO), Istituto Italiano di Tecnologia (IIT), University of Michigan [Ann Arbor], University of Michigan System, King‘s College London, Virologie et Immunologie Moléculaires (VIM (UR 0892)), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute of Complex Systems (ICS), Forschungszentrum Jülich GmbH | Centre de recherche de Juliers, Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Natural Sciences and Engineering Council (NSERC) of Canada, Italian MIUR program PRIN 20157WZM8A, Progetto di Dipartimento 2017–2020, Swiss National Science Foundation, and EU Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant no. 754490
Subjects: 0301 basic medicine, Protein Denaturation, Protein Folding, 030103 biophysics, Amyloid, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Dimer, Biophysics, Peptide, Molecular dynamics, Molecular Dynamics Simulation, Spectrum Analysis, Raman, Intrinsically disordered proteins, Analytical model, Protein Structure, Secondary, Electrolytes, 03 medical and health sciences, chemistry.chemical_compound, ddc:570, Humans, Computer Simulation, Symmetry-breaking, Colloids, Symmetry breaking, chemistry.chemical_classification, Reproducibility of Results, General Medicine, Models, Theoretical, Islet Amyloid Polypeptide, Kinetics, 030104 developmental biology, chemistry, Oligomers, Solvents, Thermodynamics, Protein folding, Self-assembly, Protein Multimerization, Peptides
Abstract: International audience; Protein misfolding and subsequent self-association are complex, intertwined processes, resulting in development of a heterogeneous population of aggregates closely related to many chronic pathological conditions including Type 2 Diabetes Mellitus and Alzheimer’s disease. To address this issue, here, we develop a theoretical model in the general framework of linear stability analysis. According to this model, self-assemblies of peptides with pronounced conformational flexibility may become, under particular conditions, unstable and spontaneously evolve toward an alternating array of partially ordered and disordered monomers. The predictions of the theory were verified by atomistic molecular dynamics (MD) simulations of islet amyloid polypeptide (IAPP) used as a paradigm of aggregation-prone polypeptides (proteins). Simulations of dimeric, tetrameric, and hexameric human-IAPP self-assemblies at physiological electrolyte concentration reveal an alternating distribution of the smallest domains (of the order of the peptide mean length) formed by partially ordered (mainly β-strands) and disordered (turns and coil) arrays. Periodicity disappears upon weakening of the inter-peptide binding, a result in line with the predictions of the theory. To further probe the general validity of our hypothesis, we extended the simulations to other peptides, the Aβ(1–40) amyloid peptide, and the ovine prion peptide as well as to other proteins (SOD1 dimer) that do not belong to the broad class of intrinsically disordered proteins. In all cases, the oligomeric aggregates show an alternate distribution of partially ordered and disordered monomers. We also carried out Surface Enhanced Raman Scattering (SERS) measurements of hIAPP as an experimental validation of both the theory and in silico simulations.
Published: 2020
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20. Ion mobility spectrometry combined with multivariate statistical analysis: revealing the effects of a drug candidate for Alzheimer’s disease on Aβ1-40 peptide early assembly

Author: Serena Lazzaro, Lieke Lamont, Nina Ogrinc, Giuseppe Pappalardo, Ron M. A. Heeren, Graziella Vecchio, National Research Council [Catania], The Maastricht Multimodal Molecular Imaging Institute, University of Catania [Italy], and SALZET, Michel
Subjects: Spectrometry, Mass, Electrospray Ionization, Multivariate statistics, Ion-mobility spectrometry, [SDV]Life Sciences [q-bio], Alzheimer’s disease (AD), Peptide, 02 engineering and technology, Mass spectrometry, Multivariate statistical analysis (MVA), 01 natural sciences, Biochemistry, Amyloid β-peptide oligomers, Electrospray ionization-ion mobility-mass spectrometry (ESI-IM-MS), Analytical Chemistry, Alzheimer Disease, Tandem Mass Spectrometry, Ion Mobility Spectrometry, Humans, chemistry.chemical_classification, Amyloid beta-Peptides, Drug discovery, 010401 analytical chemistry, 021001 nanoscience & nanotechnology, Peptide Fragments, In vitro, 3. Good health, 0104 chemical sciences, [SDV] Life Sciences [q-bio], Drug development, chemistry, Multivariate Analysis, 0210 nano-technology, Alzheimer's disease (AD) . Amyloid ?-peptide oligomers . Electrospray ionization-ion mobility-mass spectrometry (ESI-IM-MS) . Multivariate statistical analysis (MVA), Research Paper, Conjugate
Abstract: Inhibition of the initial stages of amyloid-β peptide self-assembly is a key approach in drug development for Alzheimer’s disease, in which soluble and highly neurotoxic low molecular weight oligomers are produced and aggregate in the brain over time. Here we report a high-throughput method based on ion mobility mass spectrometry and multivariate statistical analysis to rapidly select statistically significant early-stage species of amyloid-β1-40 whose formation is inhibited by a candidate theranostic agent. Using this method, we have confirmed the inhibition of a Zn-porphyrin-peptide conjugate in the early self-assembly of Aβ40 peptide. The MS/MS fragmentation patterns of the species detected in the samples containing the Zn-porphyrin-peptide conjugate suggested a porphyrin-catalyzed oxidation at Met-35(O) of Aβ40. We introduce ion mobility MS combined with multivariate statistics as a systematic approach to perform data analytics in drug discovery/amyloid research that aims at the evaluation of the inhibitory effect on the Aβ early assembly in vitro models at very low concentration levels of Aβ peptides. Electronic supplementary material The online version of this article (10.1007/s00216-019-02030-7) contains supplementary material, which is available to authorized users.
Published: 2019
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21. Oral nomegestrol acetate and transdermal 17-beta-estradiol for preventing post-partum relapses in multiple sclerosis: The POPARTMUS study

Author: Martine El-Etr, Jérôme De Seze, Patrick Hautecoeur, Françoise Durand-Dubief, Jean Pelletier, Etienne-Emile Baulieu, Francesco Patti, David-Axel Laplaud, L. Gignoux, Maria Trojano, Emmanuelle Le Page, Sandra Vukusic, Pierre Clavelou, Luca Durelli, Iuliana Ionescu, David Brassat, Eric Berger, Catherine Cornu, Laurent Remontet, Nadine Bossard, Giovanni Castelnovo, Marc Debouverie, François Cotton, Olivier Heinzlef, Romain Marignier, Thibault Moreau, Christine Lebrun-Frenay, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL), Observatoire Français de la Sclérose En Plaques [Lyon] (OFSEP), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Service Hospitalo-Universitaire de Pharmacologie et Toxicologie - Lyon (SHUPT Lyon), Service de Biostatistiques [Lyon], Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Neuroradiologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Università degli studi di Torino = University of Turin (UNITO), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Neuro-Dol (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Strasbourg, Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pôle Neurosciences [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Assistance Publique - Hôpitaux de Marseille (APHM), Unité de Recherche Clinique de la Côte d’Azur (URRIS UR2CA), Centre Hospitalier Universitaire de Nice (CHU Nice)-Université Côte d'Azur (UCA), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Service de Neurologie [CHU Nimes] (Pôle NIRR), Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Service de Neurologie [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Département de neurologie [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHI Poissy-Saint-Germain, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), University of Catania [Italy], Petites Molécules de neuroprotection, neurorégénération et remyélinisation, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Association Européenne contre les Leucodystrophies, Myelin Project, Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques, Programme Hospitalier de Recherche Clinique 2005, Ministère des Affaires Sociales et de la Santé, Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Torino (UNITO), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pôle neurosciences [Hôpital de Purpan - Toulouse], CHU Toulouse [Toulouse], Unité de Recherche Clinique de la Côte d’Azur [Nice] (URRIS UR2CA), Université Côte d'Azur (UCA), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neurologie[Lille], Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Università degli studi di Bari Aldo Moro (UNIBA), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL)
Subjects: Nomegestrol acetate, medicine.medical_specialty, relapses, Norpregnadienes, [SDV]Life Sciences [q-bio], Relapse rate, progesterone, Gastroenterology, sex hormones, Multiple sclerosis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, Recurrence, Internal medicine, estradiol, Medicine, Humans, Post partum, Transdermal, business.industry, Postpartum Period, post-partum, Megestrol, medicine.disease, 17 beta estradiol, 3. Good health, Neurology, chemistry, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, 030215 immunology
Abstract: Background: Sex steroids could explain the course of multiple sclerosis (MS) in pregnancy. Objective: To compare the annualized relapse rate (ARR) 12 weeks post-partum in women treated with nomegestrol acetate (NOMAc) and 17-beta-estradiol (E2) versus placebo. Methods: POPARTMUS is a randomized, proof-of-concept trial in women with MS, receiving oral NOMAc 10 mg/day and transdermal estradiol 75 µg/week, or placebo. Results: Recruitment was stopped prematurely due to slow inclusions ( n = 202). No treatment effect was observed on ARR after 12 weeks (sex steroids = 0.90 (0.58–1.39), placebo = 0.97 (0.63–1.50) ( p = 0.79)). Conclusion: POPARTMUS failed showing efficacy of a NOMAc–E2 combination in preventing post-partum relapses.
Published: 2021
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22. Analysis and Design of Bessel Beam Launchers: Transverse Polarization

Author: Santi C. Pavone, Mauro Ettorre, Massimiliano Casaletti, Matteo Albani, University of Catania [Italy], Institut d'Électronique et des Technologies du numéRique (IETR), Université de Nantes (UN)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Laboratoire Génie électrique et électronique de Paris (GeePs), CentraleSupélec-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Siena = University of Siena (UNISI), Université de Nantes (UN)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), and Nantes Université (NU)-Université de Rennes 1 (UR1)
Subjects: Diffraction, Physics, Radial line slot array (RLSA), Field (physics), business.industry, Aperture, Nondiffractive beams, Astrophysics::Instrumentation and Methods for Astrophysics, RLSA, Bessel beams, Polarization (waves), non-diffractive beams, symbols.namesake, Transverse plane, [SPI]Engineering Sciences [physics], Optics, circular polarization, Bessel beam, symbols, near-field focusing, Electrical and Electronic Engineering, business, Bessel function, Beam (structure)
Abstract: International audience; In this paper, we present a theoretical analysis, one design and fabrication of a limited-diffractive planar Bessel beam launcher, that exhibits a zeroth order Bessel profile in the transverse electric field component with respect to the z-propagation axis. The launcher is designed by synthesizing a finite zeroth order, first kind Hankel aperture distribution, polarized along a fixed polarization unit vector. The field radiated by such an aperture distribution is derived by following an approximate model based on geometric theory of diffraction, thus allowing to highlight the relevant wave constituents involved in transverse Bessel beam generation, also including the effect of aperture truncation on the radiated beam. Moreover, the theoretical analysis has been profitably applied to the design of a circularpolarized planar transverse Bessel beam launcher by means of a slotted radial waveguide. A prototype of right-handed circular polarized (RHCP) transverse Bessel beam launcher has been then fabricated at f = 30 GHz. The measured transverse electric field component shows a satisfactory agreement with full-wave numerical simulations. IEEE
Published: 2021
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23. Toxoplasma gondii and multiple sclerosis: A systematic review and meta-analysis

Author: Alessandra Nicoletti, Pierre-Marie Preux, Francesca Elsa Allibrio, Loretta Giuliano, Calogero Edoardo Cicero, Jaime Luna, University of Catania [Italy], Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
Subjects: medicine.medical_specialty, Multiple Sclerosis, Protective factor, Toxoplasma gondii, Antibodies, Protozoan, hygiene hypothesis, 03 medical and health sciences, Global population, 0302 clinical medicine, Hygiene hypothesis, Risk Factors, Seroepidemiologic Studies, Internal medicine, parasitic diseases, Medicine, Humans, 030304 developmental biology, parasitic infections, 0303 health sciences, biology, business.industry, Multiple sclerosis, Odds ratio, biology.organism_classification, medicine.disease, Confidence interval, 3. Good health, meta-analysis, Neurology, Meta-analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), business, Toxoplasma, 030217 neurology & neurosurgery, Toxoplasmosis
Abstract: International audience; Background and purpose: According to the hygiene hypothesis, infections by agents such as parasites have a protective role against the risk of developing multiple sclerosis (MS). Among parasites, Toxoplasma gondii, an intracellular parasite, showed evidence of a protective effect. This study was undertaken to summarize the available evidence on the association between T. gondii infection and MS. Methods: A systematic review of all the available articles published up to November 2020 has been conducted independently by two investigators in the following databases: PubMed, Scopus, Lissa, and SciELO. The association between T. gondii infection and MS has been pooled with a random effects model. Results: From 562 articles, seven were included in the systematic review and meta-analysis for a global population of 752 MS cases and 1282 controls. T. gondii infection was associated with MS with a pooled odds ratio of 0.68 (95% confidence interval = 0.50-0.93). Conclusions: The available evidence supports the hypothesis that T. gondii infection represents a protective factor against the development of MS.
Published: 2021
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24. Phosphonodithioester-amine coupling in water: a fast reaction to modify the surface of liposomes

Author: Paul-Alain Jaffrès, Dany Jeanne Dit Fouque, Aurélien Dupont, Mathieu Berchel, Montassar Khalil, Aurore Fraix, Salvatore Sortino, Antony Memboeuf, Chimie, Electrochimie Moléculaires et Chimie Analytique (CEMCA), Université de Brest (UBO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO), University of Catania [Italy], Biosit : biologie, santé, innovation technologique (SFR UMS CNRS 3480 - INSERM 018), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: liposomes, réaction dans l’eau, [SDV]Life Sciences [q-bio], Kinetics, education, Phospholipid, 010402 general chemistry, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Reaction rate constant, Amphiphile, [CHIM]Chemical Sciences, Physical and Theoretical Chemistry, réaction click, amphiphiles, Liposome, no metal, reaction in water, sans métal, 010405 organic chemistry, Organic Chemistry, food and beverages, Combinatorial chemistry, 0104 chemical sciences, Coupling (electronics), chemistry, click chemistry, Click chemistry, Amine gas treating
Abstract: International audience; The incorporation of lipophilic phosphonodithioesters in phospholipid formulations generates clickable liposomes that react with amines. The kinetics of this metal free phosphonodithioester-amine coupling (PAC) on liposomes in water is reported and can be classified as a fast reaction with a second order rate constant of k ≈ 8 × 102 M-1 s-1. The PAC reaction represents a versatile strategy to functionalize liposomes.
Published: 2021
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25. Collective flow properties of intermediate mass fragments and isospin effects in fragmentation at Fermi energies

Author: Di Toro, M. [Laboratori Nazionali del Sud INFN, Catania, Italy and Physics and Astronomy Department, University of Catania (Italy)]
Published: 2013
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26. Development of a portable hypoxia chamber for ultra-high dose rate laser-driven proton radiobiology applications

Author: D. Gwynne, Stephen J. McMahon, David Carroll, Giuliana Milluzzo, H. Padda, Kevin M. Prise, Boris Odlozilik, Domenico Doria, Marco Borghesi, Hamad Ahmed, Giada Petringa, G.A.P. Cirrone, Paul McKenna, Satyabrat Karr, Lorenzo Romagnani, Pankaj Chaudhary, Roberto Catalano, James Green, Aaron Alejo, Carla Maiorino, Aaron McMurray, Nicola Booth, Francesco P Cammaratta, Queen's University [Belfast] (QUB), Laboratoire pour l'utilisation des lasers intenses (LULI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Fisica Nucleare (INFN), Istituto Nazionale di Fisica Nucleare, Sezione di Catania (INFN), Università degli studi di Catania = University of Catania (Unict), University of Catania [Italy], Laboratori Nazionali del Sud (LNS), and the European Union’s Horizon 2020 research and innovation program under the Marie Sklowdowska-Curie grant agreement no 754507
Subjects: Radiobiology, Materials science, Proton, DNA repair, law.invention, RC0254, SDG 3 - Good Health and Well-being, law, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], medicine, Humans, Radiology, Nuclear Medicine and imaging, Hypoxia, DNA/radiation effects, Lasers, DNA, Hypoxia (medical), Laser, Oxygen, Oncology, Laser-driven protons, Biophysics, medicine.symptom, Protons, Dose rate, Ultra-high dose rate
Abstract: Background There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect observed in FLASH radiotherapy, where particles are delivered at 40–1000 Gy/s. Furthermore, the development of laser-driven accelerators now enables radiobiology experiments in extreme regimes where dose rates can exceed 109 Gy/s, and predicted oxygen depletion effects on cellular response can be tested. Access to appropriate experimental enviroments, allowing measurements under controlled oxygenation conditions, is a key requirement for these studies. We report on the development and application of a bespoke portable hypoxia chamber specifically designed for experiments employing laser-driven sources, but also suitable for comparator studies under FLASH and conventional irradiation conditions. Materials and methods We used oxygen concentration measurements to test the induction of hypoxia and the maintenance capacity of the chambers. Cellular hypoxia induction was verified using hypoxia inducible factor-1α immunostaining. Calibrated radiochromic films and GEANT-4 simulations verified the dosimetry variations inside and outside the chambers. We irradiated hypoxic human skin fibroblasts (AG01522B) cells with laser-driven protons, conventional protons and reference 225 kVp X-rays to quantify DNA DSB damage and repair under hypoxia. We further measured the oxygen enhancement ratio for cell survival after X-ray exposure in normal fibroblast and radioresistant patient- derived GBM stem cells. Results Oxygen measurements showed that our chambers maintained a radiobiological hypoxic environment for at least 45 min and pathological hypoxia for up to 24 h after disconnecting the chambers from the gas supply. We observed a significant reduction in the 53BP1 foci induced by laser-driven protons, conventional protons and X-rays in the hypoxic cells compared to normoxic cells at 30 min post-irradiation. Under hypoxic irradiations, the Laser-driven protons induced significant residual DNA DSB damage in hypoxic AG01522B cells compared to the conventional dose rate protons suggesting an important impact of these extremely high dose-rate exposures. We obtained an oxygen enhancement ratio (OER) of 2.1 ± 0.1 and 2.5 ± 0.1 respectively for the AG01522B and patient-derived GBM stem cells for X-ray irradiation using our hypoxia chambers. Conclusion We demonstrated the design and application of portable hypoxia chambers for studying cellular radiobiological endpoints after exposure to laser-driven protons at ultra-high dose, conventional protons and X-rays. Suitable levels of reduced oxygen concentration could be maintained in the absence of external gassing to quantify hypoxic effects. The data obtained provided indication of an enhanced residual DNA DSB damage under hypoxic conditions at ultra-high dose rate compared to the conventional protons or X-rays.
Published: 2021
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27. Correction to: Thermal biology of Tuta absoluta: demographic parameters and facultative diapause

Author: Philippe Béarez, Mateus R. Campos, Luigi Ponti, Andrew Paul Gutierrez, Edwige Amiens-Desneux, Antonio Biondi, Nicolas Desneux, Abhijin Adiga, Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), Agenzia Nazionale per le nuove Tecnologie, l’energia e lo sviluppo economico sostenibile (ENEA), University of California [Berkeley], University of California, University of Catania [Italy], and The University of Virginia
Subjects: 0106 biological sciences, Entomology, Facultative, Ecology, Ecology (disciplines), [SDV]Life Sciences [q-bio], Biology, Diapause, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Computer Science::Digital Libraries, 010602 entomology, Tuta absoluta, Agronomy and Crop Science, ComputingMilieux_MISCELLANEOUS
Abstract: Formula, Equation 2 and the table 3 are published incorrectly in the original publication of the article. The correct version of the article is given below
Published: 2021
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28. Clinical-Instrumental patterns of neurodegeneration in Essential Tremor: A data-driven approach

Author: Alessandra Nicoletti, Joseph Jankovic, Loretta Giuliano, Calogero Edoardo Cicero, Mario Zappia, Clara Grazia Chisari, Roberta Terranova, Pierre-Marie Preux, Marco Davì, Antonina Luca, Claudio Terravecchia, Cristina Rascunà, Giovanni Mostile, IRCCS Associazione Oasi Maria SS, Institute for Research on Mental Retardation and Brain Aging, Troina (EN), Italy, University of Catania [Italy], University of Palermo, Italy, Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), and Baylor College of Medecine
Subjects: 0301 basic medicine, Retinal degeneration, Male, medicine.medical_specialty, Head tremor, Timed up and go test, Retina, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, 80 and over, Neurologic, Medicine, Humans, Cognitive Dysfunction, Gait Disorders, Cognitive decline, Neurodegeneration, Tomography, Gait Disorders, Neurologic, Aged, Aged, 80 and over, Essential tremor, Optical coherence tomography, business.industry, Neuropsychology, Cognition, Neurodegenerative Diseases, medicine.disease, Action tremor, Gait, 030104 developmental biology, Neurology, Optical Coherence, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Tomography, Optical Coherence
Abstract: Introduction Essential Tremor (ET) is increasingly recognized as a complex disorder with additional clinical signs other than tremor. It is still unknown whether a unique pathophysiologic or neurodegenerative process underlies progression and prognosis of the disease. The aim of the study was to identify ET phenotypes through a clinical-instrumental data-driven approach and to characterize possible patterns of neurodegeneration. Methods ET patients were categorized using spatio-temporal and kinematic variables related to mobility and dynamic stability processed by motion transducers. Differences between the identified groups in clinical-demographic variables, neuropsychological performances and retinal parameters by Optical Coherence Tomography (OCT) segmentation analysis were tested. Results Twenty-five ET patients were studied. Based on clustering of kinematic and spatio-temporal gait parameters, two independent groups were identified: cluster “A” (N = 15) and cluster “B” (N = 10). Compared to group A, group B had overall worse performance in mobility, especially on turning tasks. Identified clusters did not differ in terms of age, age at onset and disease duration. Patients in group B had more head tremor and more severe action tremor in the upper limbs as compared to group A, demonstrating also worse performances on cognitive assessments. Based on OCT analysis, group B presented a reduced thickness of the retinal inner layer as compared to group A, suggesting underlying neurodegenerative processes. Conclusions The presence of gait and mobility impairment, associated with midline tremor, cognitive decline and retinal degeneration suggests a subtype of ET associated with neurodegeneration.
Published: 2021
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29. Trends in molecular diagnosis and diversity studies for phytosanitary regulated Xanthomonas

Author: Catara, Vittoria, Cubero, Jaime, Pothier, Joël F., Bosis, Eran, Bragard, Claude, Đermić, Edyta, Holeva, Maria C., Jacques, Marie-Agnès, Petter, Francoise, Pruvost, Olivier, Robène, Isabelle, Studholme, David J., Tavares, Fernando, Vicente, Joana G., Koebnik, Ralf, Costa, Joana, Università degli Studi di Catania, Agencia Estatal de Investigación (España), European Commission, University of Zurich, Scottish Government, Catara, Vittoria, Cubero, Jaime, Pothier, Joël F., Bosis, Eran, Bragard, Claude, Đermić, Edyta, Holeva, Maria C., Jacques, Marie-Agnès, Petter, Francoise, Pruvost, Olivier, Robène, Isabelle, Studholme, David J., Tavares, Fernando, Vicente, Joana G., Koebnik, Ralf, Costa, Joana, University of Catania [Italy], Department of Agriculture, Food and Environment, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria = National Institute for Agricultural and Food Research and Technology (INIA), Zürich University of Applied Sciences (ZHAW), ORT Braude College [Karmiel, Israel], Earth and Life Institute [Louvain-La-Neuve] (ELI), Université Catholique de Louvain = Catholic University of Louvain (UCL), Faculty of Agriculture [Zagreb] (UNIZG), University of Zagreb, Benaki Phytopathological Institute, Institut de Recherche en Horticulture et Semences (IRHS), Université d'Angers (UA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), European and Mediterranean Plant Protection Organization - Organisation Européenne et Méditerranéenne pour la Protection des Plantes (EPPO), Peuplements végétaux et bioagresseurs en milieu tropical (UMR PVBMT), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université de La Réunion (UR)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), University of Exeter, Biosciences, College of Life and Environmental Sciences, Faculdade de Ciências da Universidade do Porto (FCUP), Universidade do Porto, Centro de Investigacão em Biodiversidade e Recursos Genéticos (CIBIO), Fera Science Ltd, Plant Health Institute of Montpellier (UMR PHIM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), University of Coimbra [Portugal] (UC), Centre for Functional Ecology, Instituto Pedro Nunes (IPN), J.C. (Joana Costa) acknowledges R&D Unit Center for Functional Ecology-Science for People and the Planet (CFE), with reference UIDB/04004/2020, financed by FCT/MCTES through national funds (PIDDAC). V.C. acknowledges support of the University of Catania PIA.CE.RI. 2020–2022Linea 2-Research Project MEDIT-ECO. J.C. acknowledges support from AEI by RTI 2018-096018-R-C31 and FEDER. O.P. and I.R. acknowledge the European Union (ERDF, EAFRD) and Réunion regional council for support. J.F.P. acknowledges support from the Department of Life Sciences and Facility Management of the Zurich University of Applied Sciences (ZHAW) in Wädenswil. D.J.S. and J.G.V. also acknowledge joint funding by a grant from BBSRC, NERC, Defra, and the Scottish Government, under the Strategic Priorities Fund Plant Bacterial Diseases programme under the project ‘Xanthomonas plants diseases: mitigating existing, emerging and future threats to UK agriculture’ (BB/T010916/1 and BB/T010908/1). The APC was funded by COST (European Cooperation inScience and technology)., Benaki Phytopathological Institute (BPI), Université d'Angers (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Universidade do Porto = University of Porto, Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université de Montpellier (UM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Centre for Functional ecology, and UCL - SST/ELI/ELIM - Applied Microbiology
Subjects: Xanthomonas, QH301-705.5, Review, molecular methods, Maladie des plantes, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Diagnostic, Biology (General), H20 - Maladies des plantes, Regulated non-quarantine pests, 572: Biochemie, Biotechnologie végétale, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Maladie bactérienne, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, quarantine pests, Molecular methods, Quarantine pests, 579: Mikrobiologie, Mesure phytosanitaire, regulated non-quarantine pests
Abstract: 30 Pág. Departamento de Protección Vegetal (INIA), Bacteria in the genus Xanthomonas infect a wide range of crops and wild plants, with most species responsible for plant diseases that have a global economic and environmental impact on the seed, plant, and food trade. Infections by Xanthomonas spp. cause a wide variety of non-specific symptoms, making their identification difficult. The coexistence of phylogenetically close strains, but drastically different in their phenotype, poses an added challenge to diagnosis. Data on future climate change scenarios predict an increase in the severity of epidemics and a geographical expansion of pathogens, increasing pressure on plant health services. In this context, the effectiveness of integrated disease management strategies strongly depends on the availability of rapid, sensitive, and specific diagnostic methods. The accumulation of genomic information in recent years has facilitated the identification of new DNA markers, a cornerstone for the development of more sensitive and specific methods. Nevertheless, the challenges that the taxonomic complexity of this genus represents in terms of diagnosis together with the fact that within the same bacterial species, groups of strains may interact with distinct host species demonstrate that there is still a long way to go. In this review, we describe and discuss the current molecular-based methods for the diagnosis and detection of regulated Xanthomonas, taxonomic and diversity studies in Xanthomonas and genomic approaches for molecular diagnosis., J.C. (Joana Costa) acknowledges R&D Unit Center for Functional Ecology-Science for People and the Planet (CFE), with reference UIDB/04004/2020, financed by FCT/MCTES through national funds (PIDDAC). V.C. acknowledges support of the University of Catania PIA.CE.RI. 2020–2022 Linea 2-Research Project MEDIT-ECO. J.C. acknowledges support from AEI by RTI2018-096018-R-C31 and FEDER. O.P. and I.R. acknowledge the European Union (ERDF, EAFRD) and Réunion regional council for support. J.F.P. acknowledges support from the Department of Life Sciences and Facility Management of the Zurich University of Applied Sciences (ZHAW) in Wädenswil. D.J.S. and J.G.V. also acknowledge joint funding by a grant from BBSRC, NERC, Defra, and the Scottish Government, under the Strategic Priorities Fund Plant Bacterial Diseases programme under the project ‘Xanthomonas plants diseases: mitigating existing, emerging and future threats to UK agriculture’ (BB/T010916/1 and BB/T010908/1). The APC was funded by COST (European Cooperation in Science and technology).
Published: 2021
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30. Mortality following Clostridioides difficile infection in Europe

Author: Czepiel, Jacek, Krutova, Marcela, Mizrahi, Assaf, Khanafer, Nagham, Enoch, David A., Patyi, Márta, Deptuła, Aleksander, Agodi, Antonella, Nuvials, Xavier, Pituch, Hanna, Wójcik-Bugajska, Małgorzata, Filipczak-Bryniarska, Iwona, Brzozowski, Bartosz, Krzanowski, Marcin, Konturek, Katarzyna, Fedewicz, Marcin, Michalak, Mateusz, Monpierre, Lorra, Vanhems, Philippe, Gouliouris, Theodore, Jurczyszyn, Artur, Goldman-Mazur, Sarah, Wultańska, Dorota, Kuijper, Ed J., Skupień, Jan, Biesiada, Grażyna, Garlicki, Aleksander, Universitat Autònoma de Barcelona, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Charles University [Prague] (CU), ESCMID Study Group for Clostridioides Difficile (ESGCD), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groupe Hospitalier Paris Saint-Joseph (hpsj), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Addenbrooke's Hospital, Cambridge University NHS Trust, Bács-Kiskun County Teaching Hospital, Nicolaus Copernicus University [Toruń], University of Catania [Italy], Vall d'Hebron University Hospital [Barcelona], Medical University of Warsaw - Poland, University Hospital of Cracow/Szpital Uniwersytecki w Krakowie [Poland] (SUK), Józef Babinski Hospital, Ludwik Rydygier Hospital, Leiden University Medical Center (LUMC), Universiteit Leiden, Rijksinstituut voor Volksgezondheid en Milieu (RIVM), Institut Català de la Salut, [Czepiel J] Department of Infectious and Tropical Diseases, Jagiellonian University Medical College, Krakow, Poland. [Krutova M] Department of Medical Microbiology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic. ESCMID Study Group for Clostridioides Difficile (ESGCD), Basel, Switzerland. [Mizrahi A] ESCMID Study Group for Clostridioides Difficile (ESGCD), Basel, Switzerland. Service de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France. Institut Micalis UMR 1319, Université Paris-Saclay, INRAe, AgroParisTech, Châtenay Malabry, France. [Khanafer N] ESCMID Study Group for Clostridioides Difficile (ESGCD), Basel, Switzerland. Unité d’Hygiène, Epidémiologie et Prévention, Groupement Hospitalier Centre, Hospices Civils de Lyon, Lyon, France. Centre International de Recherche en Infectiologie (CIRI), Public Health, Epidemiology and Evolutionary Ecology of Infectious Diseases (PHE3ID), Université de Lyon, Lyon, France. [Enoch DA] Clinical Microbiology & Public Health Laboratory, Public Health England, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK. [Patyi M] Hygienic Department, Bács-Kiskun County Teaching Hospital, Bács-Kiskun, Hungary. [Nuvials X] Servei de Medicina Intensiva, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de recerca SODIR, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Casal, Bérengère
Subjects: 0301 basic medicine, genetic structures, Clostridioides difficile infection, [SDV]Life Sciences [q-bio], Antibiotics, técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de casos y controles [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Logistic regression, Biochemistry, chemistry.chemical_compound, 0302 clinical medicine, Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Clostridium Infections [DISEASES], risk factors, Pharmacology (medical), 030212 general & internal medicine, Co-morbidities, General Pharmacology, Toxicology and Pharmaceutics, Outcome, Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Case-Control Studies [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Clostridi - Europa, [SDV] Life Sciences [q-bio], Infectious Diseases, Absolute neutrophil count, outcome, localizaciones geográficas::Europa (continente) [DENOMINACIONES GEOGRÁFICAS], Microbiology (medical), medicine.medical_specialty, infecciones bacterianas y micosis::infecciones bacterianas::infecciones por bacterias grampositivas::infecciones por Clostridium [ENFERMEDADES], medicine.drug_class, 030106 microbiology, Malignancy, Geographic Locations::Europe [GEOGRAPHICALS], Microbiology, Cachexia, 03 medical and health sciences, Internal medicine, Other subheadings::Other subheadings::Other subheadings::/mortality [Other subheadings], medicine, Mortality, Creatinine, Clostridioides Clostridioides difficile infection, Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad [Otros calificadores], business.industry, lcsh:RM1-950, Case-control study, medicine.disease, mortality, co-morbidities, lcsh:Therapeutics. Pharmacology, chemistry, Risk factors, co–morbidities, Malalties bacterianes - Estudi de casos, business, Clostridioides, malignancy
Abstract: We aimed to describe the clinical presentation, treatment, outcome and report on factors associated with mortality over a 90-day period in Clostridioides difficile infection (CDI). Descriptive, univariate, and multivariate regression analyses were performed on data collected in a retrospective case-control study conducted in nine hospitals from seven European countries. A total of 624 patients were included, of which 415 were deceased (cases) and 209 were still alive 90 days after a CDI diagnosis (controls). The most common antibiotics used previously in both groups were β-lactams, previous exposure to fluoroquinolones was significantly (p = 0.0004) greater in deceased patients. Multivariate logistic regression showed that the factors independently related with death during CDI were older age, inadequate CDI therapy, cachexia, malignancy, Charlson Index, long-term care, elevated white blood cell count (WBC), C-reactive protein (CRP), bacteraemia, complications, and cognitive impairment. In addition, older age, higher levels of WBC, neutrophil, CRP or creatinine, the presence of malignancy, cognitive impairment, and complications were strongly correlated with shortening the time from CDI diagnosis to death. CDI prevention should be primarily focused on hospitalised elderly people receiving antibiotics. WBC, neutrophil count, CRP, creatinine, albumin and lactate levels should be tested in every hospitalised patient treated for CDI to assess the risk of a fatal outcome.
Published: 2021
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31. Accuracy of the PARIS score and PCI complexity to predict ischemic events in patients treated with very thin stents in unprotected left main or coronary bifurcations

Author: Mario Bo, Ferdinando Varbella, Wojciech Wańha, Ovidio De Filippo, Giuseppe Venuti, Federico Conrotto, Bernardo Cortese, Carlo Di Mario, Filippo Figini, Guglielmo Gallone, Nicola Ryan, Francesco Piroli, Iván J. Núñez-Gil, Saverio Muscoli, Imad Sheiban, Mauro Pennacchi, Andrea Rognoni, Javier Escaned, Alessio Mattesini, Francesco Burzotta, Zenon Huczek, Gaetano M. De Ferrari, Daniela Trabattoni, Wojciech Wojakowski, Imori Yoichi, Pier Paolo Bocchino, Andrea Montabone, Giorgio Quadri, Francesco Costa, Fabrizio D'Ascenzo, Giacomo Boccuzzi, Davide Capodanno, Enrico Cerrato, Gérard Helft, Grzegorz Smolka, Radosław Parma, Cristina Rolfo, Alaide Chieffo, Satoru Mitomo, Università degli studi di Torino = University of Turin (UNITO), Università degli Studi di Messina = University of Messina (UniMe), University of Catania [Italy], University of Rome 'Tor Vergeta', Università degli Studi di Roma Tor Vergata [Roma], IRCCS Ospedale San Raffaele [Milan, Italy], Nippon Medical School [Tokyo, Japon], Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Ospedale di Rivoli [Rivoli, Italy] (OR), Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain] (IdISSC), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Medical University of Silesia (SUM), Medical University of Warsaw - Poland, Ospedale San Giovanni Bosco [Turin, Italy] (OSGB), University Hospital 'Maggiore della Carità' [Novara, Italy], Clinica Pederzoli [Peschiera del Garda, Italy] (CP), Careggi University Hospital [Florence, Italie], ASST Fatebenefratelli-Sacco [Milan, Italy], Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC), and Lesnik, Philippe
Subjects: medicine.medical_specialty, medicine.medical_treatment, left main, [SDV]Life Sciences [q-bio], Coronary Artery Disease, risk stratification, 030204 cardiovascular system & hematology, 03 medical and health sciences, Percutaneous Coronary Intervention, 0302 clinical medicine, Risk Factors, Internal medicine, Humans, Medicine, Radiology, Nuclear Medicine and imaging, In patient, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, Target lesion revascularization, Framingham Risk Score, business.industry, bifurcation, dual antiplatelet therapy, Percutaneous coronary intervention, Stent, Drug-Eluting Stents, General Medicine, medicine.disease, [SDV] Life Sciences [q-bio], Treatment Outcome, surgical procedures, operative, Conventional PCI, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Cardiology, Stents, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, Mace
Abstract: International audience; Background: The PARIS risk score (PARIS-rs) and percutaneous coronary intervention complexity (PCI-c) predict clinical and procedural residual ischemic risk following PCI. Their accuracy in patients undergoing unprotected left main (ULM) or bifurcation PCI has not been assessed.Methods: The predictive performances of the PARIS-rs (categorized as low, intermediate, and high) and PCI-c (according to guideline-endorsed criteria) were evaluated in 3,002 patients undergoing ULM/bifurcation PCI with very thin strut stents.Results: After 16 (12-22) months, increasing PARIS-rs (8.8% vs. 14.1% vs. 27.4%, p < .001) and PCI-c (15.2% vs. 11%, p = .025) were associated with higher rates of major adverse cardiac events ([MACE], a composite of death, myocardial infarction [MI], and target vessel revascularization), driven by MI/death for PARIS-rs and target lesion revascularization/stent thrombosis for PCI-c (area under the curves for MACE: PARIS-rs 0.60 vs. PCI-c 0.52, p-for-difference < .001). PCI-c accuracy for MACE was higher in low-clinical-risk patients; while PARIS-rs was more accurate in low-procedural-risk patients. ≥12-month dual antiplatelet therapy (DAPT) was associated with a lower MACE rate in high PARIS-rs patients, (adjusted-hazard ratio 0.42 [95% CI: 0.22-0.83], p = .012), with no benefit in low to intermediate PARIS-rs patients. No incremental benefit with longer DAPT was observed in complex PCI.Conclusions: In the setting of ULM/bifurcation PCI, the residual ischemic risk is better predicted by a clinical risk estimator than by PCI complexity, which rather appears to reflect stent/procedure-related events. Careful procedural risk estimation is warranted in patients at low clinical risk, where PCI complexity may substantially contribute to the overall residual ischemic risk.
Published: 2021
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32. COVID‐19 Associated Thrombosis and Coagulopathy: Review of the Pathophysiology and Implications for Antithrombotic Management

Author: Ortega‐Paz, Luis, Capodanno, Davide, Montalescot, Gilles, Angiolillo, Dominick, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), University of Catania [Italy], Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and University of Florida [Gainesville] (UF)
Subjects: Pharmacology, myocardial infarction, endothelium, anticoagulant therapy, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, SARS-CoV-2, platelets, Anticoagulants, Thrombosis COVID-19, Coronary Artery Disease, thrombosis, antiplatelet therapy
Abstract: International audience; Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which has posed a significant threat to global health. Although the infection is frequently asymptomatic or associated with mild symptoms, in a small proportion of patients it can produce an intense inflammatory and prothrombotic state that can lead to acute respiratory distress syndrome, multiple organ failure, and death. Angiotensinconverting enzyme 2 (ACE2), highly expressed in the respiratory system, has been identified as a functional receptor for SARS-CoV-2. Notably, ACE2 is also expressed in the cardiovascular system and there are multiple cardiovascular implications of COVID-19. Cardiovascular risk factors and cardiovascular disease have been associated with severe manifestations and poor prognosis in patients with COVID-19. Importantly, patients with COVID-19 may have thrombotic and coagulation abnormalities promoting a hypercoagulable state, resulting in an increased rate of thrombotic and thromboembolic events. This review will describe the pathophysiology of the cardiovascular involvement following infection by SARS-CoV-2, with a focus on thrombotic and thromboembolic manifestations and implications for antithrombotic management.
Published: 2021
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33. Appendix A to Chapter 1 Introduction

Author: Lange, Manfred A., Llasat, Maria Carmen, Snoussi, Maria, Graves, Arnault, Tellier, Julien Le, Queralt, Arnau, Vagliasindi, Grazia Maria, Cramer W, Guiot J, Marini K, The Cyprus Institute, Nicosia, Cyprus, University of Barcelona, Barcelona, Spain, Faculté des Sciences de Rabat, Université Mohammed V, Rabat, Union for the Mediterranean, Barcelona, Spain, United Nations Environment Programme / Mediterranean Action Plan (UNEP/MAP) – Barcelona Convention Secretariat, Athens, Greece, Advisory Council for the Sustainable Development of Catalonia of the Government of Catalonia (CADS), Barcelona, Spain, and University of Catania [Italy]
Subjects: [SDE]Environmental Sciences, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2021

34. Determinants of therapeutic lag in multiple sclerosis

Author: Tomas Kalincik, Marc Girard, Corinne Pottier, Murat Terzi, Jean Pelletier, Oliver Gerlach, Julie Prevost, Dana Horakova, Francois Grand'Maison, Raed Alroughani, Guillermo Izquierdo, Francesco Patti, Federico Frascoli, Maria Trojano, Franco Granella, Pamela A. McCombe, Charles B Malpas, Recai Turkoglu, Aurélie Ruet, Jonathan Ciron, Tünde Csépány, Nicolas Maubeuge, Helmut Butzkueven, Pierre Clavelou, Tamara Castillo Trivino, Marco Onofrj, Jean Philippe Camdessanche, Pierre Labauge, Vincent Van Pesch, Pierre Grammond, Abir Wahab, Roberto Bergamaschi, Aysun Soysal, Diana Ferraro, Bertrand Bourre, Olivier Gout, Jeannette Lechner-Scott, Sara Eichau, Emmanuelle Leray, Alexis Montcuquet, Pierre Duquette, Olivier Casez, Youssef Sidhom, Patrizia Sola, Bart Van Wijmeersch, Izanne Roos, Gilles Edan, Serkan Ozakbas, David Laplaud, Sandra Vukusic, Abdullatif Al Khedr, Céline Labeyrie, Philippe Cabre, Eric Thouvenot, Céline Louapre, Romain Casey, Alessandra Lugaresi, Riadh Gouider, Alasdair Coles, Eric Berger, Ivania Patry, Gerardo Iuliano, Elisabetta Cartechini, Cavit Boz, Karolina Hankiewicz, Eva Havrdova, Eduardo Aguera-Morales, J William L Brown, Jérôme De Seze, Bruno Stankoff, Olivier Heinzlef, Gilles Defer, Alexandre Prat, Chantal Nifle, Maria José Sá, Marc Debouverie, Daniele Spitaleri, Aude Maurousset, Thibault Moreau, Christine Lebrun-Frenay, Hélène Zéphir, University of Melbourne, Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Collectif de recherche handicap, autonomie et société inclusive (CoRHASI), Swinburne University of Technology [Melbourne], Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospices Civils de Lyon (HCL), Charles University [Prague], Università degli studi di Catania [Catania], Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Università degli Studi di Modena e Reggio Emilia (UNIMORE), University of Queensland [Brisbane], Monash University [Clayton], UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de neurologie, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Charles University [Prague] (CU), Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), University of Bari Aldo Moro (UNIBA), University of Catania [Italy], Hospital Virgen Macarena, Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), CHU Toulouse [Toulouse], INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA)-Hôpital de Hautepierre [Strasbourg]-Nouvel Hôpital Civil de Strasbourg, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Lille, Fernando Pessoa University, Azienda Ospedaleria Universitaria di Modena, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Universitaire de Nice (CHU Nice), Karadeniz Technical University (KTU), Università degli Studi di Macerata = University of Macerata (UNIMC), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), University of Newcastle [Australia] (UoN), Zuyderland Hospital [Heerlen, The Netherlands], Ondokuz Mayis University, University of Parma = Università degli studi di Parma [Parme, Italie], Amiri hospital, University of Salerno (UNISA), Université Catholique de Louvain = Catholic University of Louvain (UCL), Hasselt University (UHasselt), San Giuseppe Moscati Hospital [Avellino, Italie], Bakirkoy Matern & Childrens State Hosp, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Universidad de Córdoba [Cordoba], Hospital Donostia, CHU Clermont-Ferrand, Hôpital de la Timone [CHU - APHM] (TIMONE), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHI Poissy-Saint-Germain, Université de la Manouba [Tunisie] (UMA), University of Debrecen, Hôpital Charles Nicolle [Rouen], CHU Amiens-Picardie, CHU de la Martinique [Fort de France], CHU Limoges, CHU Henri Mondor, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Centre Hospitalier Sud Francilien, CH Evry-Corbeil, Centre Hospitalier de Saint-Denis [Ile-de-France], Centre Hospitalier René Dubos [Pontoise], This study was supported by the EDMUS Foundation and NHMRC [1140766,1129189, 1157717]. IR is supported by a MSIF-ARSEP McDonald fellowship grantand a Melbourne Research Scholarship. The MSBase Foundation is a not-for-profitorganization that receives support from Biogen, Novartis, Merck, Roche, Teva andSanofi Genzyme. The study was conducted separately and apart from the guidanceof the sponsors. The Observatoire Français de la Sclérose en Plaques (OFSEP) issupported by a grant provided by the French State and handled by the 'AgenceNationale de la Recherche,' within the framework of the 'Investments for the Future'program, under the reference ANR-10-COHO-002, by the Eugène Devic EDMUSFoundation against multiple sclerosis and by the ARSEP Foundation., ANR-10-COHO-0002,OFSEP,Observatoire Français de la Sclérose en Plaques(2010), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Roos I., Leray E., Frascoli F., Casey R., Brown J.W.L., Horakova D., Havrdova E.K., Debouverie M., Trojano M., Patti F., Izquierdo G., Eichau S., Edan G., Prat A., Girard M., Duquette P., Onofrj M., Lugaresi A., Grammond P., Ciron J., Ruet A., Ozakbas S., De Seze J., Louapre C., Zephir H., Sa M.J., Sola P., Ferraro D., Labauge P., Defer G., Bergamaschi R., Lebrun-Frenay C., Boz C., Cartechini E., Moreau T., Laplaud D., Lechner-Scott J., Grand'Maison F., Gerlach O., Terzi M., Granella F., Alroughani R., Iuliano G., Van Pesch V., Van Wijmeersch B., Spitaleri D.L.A., Soysal A., Berger E., Prevost J., Aguera-Morales E., McCombe P., Castillo Trivino T., Clavelou P., Pelletier J., Turkoglu R., Stankoff B., Gout O., Thouvenot E., Heinzlef O., Sidhom Y., Gouider R., Csepany T., Bourre B., Al Khedr A., Casez O., Cabre P., Montcuquet A., Wahab A., Camdessanche J.-P., Maurousset A., Patry I., Hankiewicz K., Pottier C., Maubeuge N., Labeyrie C., Nifle C., Coles A., Malpas C.B., Vukusic S., Butzkueven H., Kalincik T., Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Università degli studi di Catania = University of Catania (Unict), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg], Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), University of Newcastle [Callaghan, Australia] (UoN), Ondokuz Mayis University (OMU), Università degli studi di Parma = University of Parma (UNIPR), Universidad de Córdoba = University of Córdoba [Córdoba], University of Debrecen Egyetem [Debrecen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), CHU Henri Mondor [Créteil], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Registrie, Male, medicine.medical_specialty, Treatment response, Pediatrics, Neurology, Lag, [SDV]Life Sciences [q-bio], Aucun, multiple sclerosis, 03 medical and health sciences, Disability Evaluation, 0302 clinical medicine, Multiple Sclerosis, Relapsing-Remitting, Recurrence, medicine, Humans, Treatment effect, Disabled Persons, Registries, 030304 developmental biology, 0303 health sciences, business.industry, Multiple sclerosis, Delayed onset, medicine.disease, 3. Good health, Clinical neurology, therapeutic lag, multiple sclerosi, Disease Progression, Disabled Person, Observational study, Female, observational study, Neurology (clinical), business, 030217 neurology & neurosurgery, Human
Abstract: International audience; Objective: To explore the associations of patient and disease characteristics with the duration of therapeutic lag for relapses and disability progression.Background: Therapeutic lag represents the delay from initiation of therapy to attainment of full treatment effect. Understanding the determinants of therapeutic lag provides valuable information for personalised choice of therapy in multiple sclerosis (MS).Design/Methods: Data from MSBase, a multinational MS registry, and OFSEP, the French national registry, were used. Patients diagnosed with MS, minimum 1-year exposure to MS treatment, minimum 3-year pre-treatment follow up and yearly review were included in the analysis. By studying incidence of relapses and 6-month confirmed disability progression, the duration of therapeutic lag was calculated by identifying the first local minimum of the first derivative after treatment start in subgroups stratified by patient and disease characteristics. Pairwise analyses of univariate predictors were performed. Combinations of determinants that consistently drove differences in therapeutic lag in pair by pair analyses were included in the final model.Results: Baseline EDSS, ARR and sex were associated with duration of therapeutic lag on disability progression in univariate and pairwise bivariable analyses. In the final model, therapeutic lag was 27.8 weeks shorter in females with ARR6 compared to those with EDSS>=6 (26.6, 18.2–34.9 vs 54.3, 47.2–61.5). Baseline EDSS, ARR, sex and MS phenotype were associated with duration of therapeutic lag on relapses in univariate analyses. Pairwise bivariable analyses of the pairs of determinants suggested ependently associated with therapeutic lag. In the final model, therapeutic lag was shortest in those with RRMS and EDSS
Published: 2021
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35. Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Author: Phillips, Helen R. P., Bach, Elizabeth M., Bartz, Marie L. C., Bennett, Joanne M., Beugnon, Rémy, Briones, Maria J. I., Brown, George G., Ferlian, Olga, Gongalsky, Konstantin B., Guerra, Carlos A., König-Ries, Birgitta, Krebs, Julia J., Orgiazzi, Alberto, Ramirez, Kelly S., Russell, David J., Schwarz, Benjamin, Wall, Diana H., Brose, Ulrich, Decaëns, Thibaud, Lavelle, Patrick, Loreau, Michel, Mathieu, Jérôme, Mulder, Christian, van der Putten, Wim H., Rillig, Matthias C., Thakur, Madhav P., de Vries, Franciska T., Wardle, David A., Ammer, Christian, Ammer, Sabine, Arai, Miwa, Ayuke, Fredrick O., Baker, Geoff H., Baretta, Dilmar, Barkusky, Dietmar, Beauséjour, Robin, Bedano, Jose C., Birkhofer, Klaus, Blanchart, Eric, Blossey, Bernd, Bolger, Thomas, Bradley, Robert L., Brossard, Michel, Burtis, James C., Capowiez, Yvan, Cavagnaro, Timothy R., Choi, Amy, Clause, Julia, Cluzeau, Daniel, Coors, Anja, Crotty, Felicity V., Crumsey, Jasmine M., Dávalos, Andrea, Cosín, Darío J. Díaz, Dobson, Annise M., Domínguez, Anahí, Duhour, Andrés Esteban, van Eekeren, Nick, Emmerling, Christoph, Falco, Liliana B., Fernández, Rosa, Fonte, Steven J., Fragoso, Carlos, Franco, André L. C., Fusilero, Abegail, Geraskina, Anna P., Gholami, Shaieste, González, Grizelle, Gundale, Michael J., López, Mónica Gutiérrez, Hackenberger, Branimir K., Hackenberger, Davorka K., Hernández, Luis M., Hirth, Jeff R., Hishi, Takuo, Holdsworth, Andrew R., Holmstrup, Martin, Hopfensperger, Kristine N., Lwanga, Esperanza Huerta, Huhta, Veikko, Hurisso, Tunsisa T., Iannone III, Basil V., Iordache, Madalina, Irmler, Ulrich, Ivask, Mari, Jesús, Juan B., Johnson-Maynard, Jodi L., Joschko, Monika, Kaneko, Nobuhiro, Kanianska, Radoslava, Keith, Aidan M., Kernecker, Maria L., Koné, Armand W., Kooch, Yahya, Kukkonen, Sanna T., Lalthanzara, H., Lammel, Daniel R., Lebedev, Iurii M., Le Cadre, Edith, Lincoln, Noa K., López-Hernández, Danilo, Loss, Scott R., Marichal, Raphael, Matula, Radim, Minamiya, Yukio, Moos, Jan Hendrik, Moreno, Gerardo, Morón-Ríos, Alejandro, Motohiro, Hasegawa, Muys, Bart, Neirynck, Johan, Norgrove, Lindsey, Novo, Marta, Nuutinen, Visa, Nuzzo, Victoria, Mujeeb Rahman, P., Pansu, Johan, Paudel, Shishir, Pérès, Guénola, Pérez-Camacho, Lorenzo, Ponge, Jean-François, Prietzel, Jörg, Rapoport, Irina B., Rashid, Muhammad Imtiaz, Rebollo, Salvador, Rodríguez, Miguel Á., Roth, Alexander M., Rousseau, Guillaume X., Rozen, Anna, Sayad, Ehsan, van Schaik, Loes, Scharenbroch, Bryant, Schirrmann, Michael, Schmidt, Olaf, Schröder, Boris, Seeber, Julia, Shashkov, Maxim P., Singh, Jaswinder, Smith, Sandy M., Steinwandter, Michael, Szlavecz, Katalin, Talavera, José Antonio, Trigo, Dolores, Tsukamoto, Jiro, Uribe-López, Sheila, de Valença, Anne W., Virto, Iñigo, Wackett, Adrian A., Warren, Matthew W., Webster, Emily R., Wehr, Nathaniel H., Whalen, Joann K., Wironen, Michael B., Wolters, Volkmar, Wu, Pengfei, Zenkova, Irina V., Zhang, Weixin, Cameron, Erin K., Eisenhauer, Nico, German Centre for Integrative Biodiversity Research (iDiv), Leipzig University, Saint Mary's University [Halifax], Colorado State University [Fort Collins] (CSU), University of Coimbra [Portugal] (UC), Martin-Luther-University Halle-Wittenberg, University of Canberra, Universidade de Vigo, Embrapa Forestry, Brazilian Agricultural Research Corporation (Embrapa), A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences [Moscow] (RAS), Lomonosov Moscow State University (MSU), Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], European Commission - Joint Research Centre [Ispra] (JRC), Netherlands Institute of Ecology (NIOO-KNAW), University of Freiburg [Freiburg], Department of Biometry and Environmental System Analysis, Albert-Ludwigs-Universität Freiburg, Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Institut d'écologie et des sciences de l'environnement de Paris (iEES Paris ), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Station d'Ecologie Théorique et Expérimentale (SETE), Centre National de la Recherche Scientifique (CNRS)-Fédération de Recherche Agrobiosciences, Interactions et Biodiversité (FR AIB), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Catania [Italy], Wageningen University and Research [Wageningen] (WUR), Freie Universität Berlin, Institute for Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam [Amsterdam] (UvA), Asian School of the Environment (ASE), Nanyang Technological University [Singapour], Georg-August-University = Georg-August-Universität Göttingen, National Agriculture and Food Research Organization (NARO), University of Nairobi (UoN), Commonwealth Scientific and Industrial Research Organisation [Canberra] (CSIRO), Santa Catarina State University (UDESC), Leibniz-Zentrum für Agrarlandschaftsforschung = Leibniz Centre for Agricultural Landscape Research (ZALF), Université de Sherbrooke (UdeS), National University of Río Cuarto = Universidad Nacional de Río Cuarto (UNRC), Brandenburg University of Technology [Cottbus – Senftenberg] (BTU), Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Cornell University [New York], University College Dublin [Dublin] (UCD), Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Adelaide, University of Toronto, Ecologie et biologie des interactions (EBI), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), ECT Oekotoxikologie GmbH, Institute of Biological, Environmental and Rural Sciences (IBERS), Biotechnology and Biological Sciences Research Council (BBSRC)-Aberystwyth University, Royal Agricultural University (RAU), University of Georgia [USA], State University of New York (SUNY), Department of Biodiversity, Ecology and Evolution [Madrid], Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Yale University [New Haven], Universidad Nacional de Luján [Buenos Aires], Louis Bolk Institute (LBI), Trier University, Animal Biodiversity and Evolution, Institute of Evolutionary Biology (IBE), Department of Soil and Crop Sciences [Fort Collins], Biodiversity and Systematic Network, Instituto de Ecología A.C., Department of Biology [Fort Collins], Department of Biological Science and Environmental Studies, University of the Philippines - Mindanao, Faculty of Bioscience Engineering - Laboratory of Environmental Toxicology and Aquatic Ecology, Universiteit Gent = Ghent University [Belgium] (UGENT), Center for Forest Ecology and Productivity (RAS), Razi University of Kermanshah, USDA Forest Service, Department of Forest Ecology and Management, Swedish University of Agricultural Sciences (SLU), Josip Juraj Strossmayer University of Osijek, Agriculture engineering, Agroecology Postgraduate Program, Maranhão State University, Agriculture Victoria (AgriBio), Kyushu University [Fukuoka], Minnesota Pollution Control Agency, Department of Bioscience [Aarhus], Northern Kentucky University, Departamento de Agricultura, Sociedad y Ambiente, EI Colegio de la Frontera Sur (ECOSUR), Consejo Nacional de Ciencia y Tecnología [Mexico] (CONACYT)-Consejo Nacional de Ciencia y Tecnología [Mexico] (CONACYT), Soil Physics and Land Management Group, University of Jyväskylä (JYU), College of Agriculture, Environmental and Human Sciences, Lincoln University of Missouri, School of Forest Resources and Conservation [Gainesville] (UF|IFAS|FFGS), Institute of Food and Agricultural Sciences [Gainesville] (UF|IFAS), University of Florida [Gainesville] (UF)-University of Florida [Gainesville] (UF), Banat University of Agricultural Sciences and Veterinary Medicine (USAMVBT), Christian-Albrechts University of Kiel, Tallinn University of Technology (TTÜ), University of Idaho [Moscow, USA], Faculty of Food and Agricultural Sciences, Fukushima University, Matej Bel University (UMB), UK Centre for Ecology & Hydrology, Natural Environment Research Council (NERC), Université Nangui Abrogoua (UNA), Faculty of Natural Resources and Marine Sciences [Tarbiat], Tarbiat Modares University [Tehran], Natural Resources Institute Finland (LUKE), Department of Zoology, Pachhunga University College, Skolkovo Institute of Science and Technology [Moscow] (Skoltech), Sol Agro et hydrosystème Spatialisation (SAS), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-INSTITUT AGRO Agrocampus Ouest, University of Hawai'i [Honolulu] (UH), Universidad Central de Venezuela (UCV), Instituto de Zoología y Ecología Tropical (IZET), Oklahoma State University [Stillwater] (OSU), Agrosystèmes Biodiversifiés (UMR ABSys), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Czech University of Life Sciences Prague (CZU), Tochigi Prefectural Museum, Thuenen-Institute of Biodiversity, Thuenen-Institute of Organic Farming, University of Extremadura, INDEHESA, Forestry School, Conservación de la Biodiversidad, El Colegio de la Frontera Sur, Doshisha University [Kyoto], Department of Earth and Environmental Sciences [Leuven-Heverlee], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Research Institute for Nature and Forest (INBO), School of Agricultural, Forest and Food Sciences, Bern University of Applied Sciences (BFH), Natural Area Consultants, Department of Zoology, PSMO College, CSIRO Marine and Atmospheric Research (CSIRO-MAR), Adaptation et diversité en milieu marin (AD2M), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Phipps Conservatory and Botanical Gardens (PHIPPS), Universidad de Alcalá - University of Alcalá (UAH), Forest Ecology and Restoration Group, Department of Life Sciences, Mécanismes Adaptatifs et Evolution (MECADEV), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Department of Ecology and Ecosystem Management, Geobotany, Tembotov Institute of Ecology of Mountain Territories, Russian Academy of Sciences, King Abdulaziz University, Center of Excellence in Environmental Studies, Global Change Ecology and Evolution Research Groupp (GloCEE), Department of Life Sciences, University of Alcalá, University of Minnesota [Twin Cities] (UMN), University of Minnesota System, Postgraduate Program in Biodiversity and Conservation, Federal University of Maranhão, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), College of Natural Resources, University of Wisconsin, The Morton Arboretum, Department Engineering for Crop Production, Leibniz Institute for Agricultural Engineering and Bioeconomy (ATB), School of Agriculture and Food Science, UCD School of Geography, UCD Earth Institute, University College, Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Institute of Geoecology, Leopold Franzens Universität Innsbruck - University of Innsbruck, European Academy Bozen/Bolzano (EURAC), Institute for Alpine Environment, European Academy of Bozen-Bolzano (EURAC), Institute of Physicochemical and Biological Problems in Soil Science, RAS, Institute of Mathematical Problems in Biology (IMPB RAS), Post Graduate Department of Zoology, Khalsa College Amritsar, Morton K. Blaustein Department of Earth and Planetary Sciences [Baltimore], Johns Hopkins University (JHU), Universidad de La Laguna [Tenerife - SP] (ULL), Kochi University, Juárez Autonomous University of Tabasco, Nanotechnology Engineering, Multidisciplinary Academic Division of Jalpa de Méndez, Food & Agriculture, WWF-Netherlands, Universidad Pública de Navarra [Espagne] = Public University of Navarra (UPNA), Department of Soil, Water and Climate, University of Minnesota System-University of Minnesota System, Earth Innovation Institute, University of California [Davis] (UC Davis), University of California (UC), Department of Natural Resources and Environmental Management, University of Hawaii, McGill University = Université McGill [Montréal, Canada], Natural resource sciences, The Nature Conservancy, Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Southwest Minzu University [Chengdu], Institute of Industrial Ecology Problems of the North of the Kola Science Center of RAS, Henan Agricultural University, Faculty of Biological and Environmental Sciences [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, H.R.P.P., B.K-R., and the sWorm workshops were supported by the sDiv [Synthesis Centre of the German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig (DFG FZT 118)]. H.R.P.P., O.F. and N.E. acknowledge funding by the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement no. 677232 to NE). K.S.R. and W.H.v.d.P. were supported by ERC-ADV grant 323020 to W.H.v.d.P. Also supported by iDiv (DFG FZT118) Flexpool proposal 34600850 (C.A.G. and N.E.), the Academy of Finland (285882) and the Natural Sciences and Engineering Research Council of Canada (postdoctoral fellowship and RGPIN-2019-05758) (E.K.C.), German Federal Ministry of Education and Research (01LO0901A) (D.J.R.), ERC-AdG 694368 (M.R.), the TULIP Laboratory of Excellence (ANR-10-LABX-41) (M.L), and the BBSRC David Phillips Fellowship to F.T.d.V. (BB/L02456X/1). In addition, data collection was funded by the Russian Foundation for Basic Research (12-04-01538-a, 12-04-01734-a, 14-44-03666-r_center_a, 15-29-02724-ofi_m, 16-04-01878-a 19-05-00245, 19-04-00-609-a), Tarbiat Modares University, Aurora Organic Dairy, UGC(NERO) (F. 1-6/Acctt./NERO/2007-08/1485), Natural Sciences and Engineering Research Council (RGPIN-2017-05391), Slovak Research and Development Agency (APVV-0098-12), Science for Global Development through Wageningen University, Norman Borlaug LEAP Programme and International Atomic Energy Agency (IAEA), Sao Paulo Research Foundation - FAPESP (12/22510-8), Oklahoma Agricultural Experiment Station, INIA - Spanish Agency (SUM 2006-00012-00-0), Royal Canadian Geographical Society, Environmental Protection Agency (Ireland) (2005-S-LS-8), University of Hawai'i at Manoa (HAW01127H, HAW01123M), European Union FP7 (FunDivEurope, 265171, ROUTES 265156), U.S. Department of the Navy, Commander Pacific Fleet (W9126G-13-2-0047), Science and Engineering Research Board (SB/SO/AS-030/2013) Department of Science and Technology, New Delhi, India, Strategic Environmental Research and Development Program (SERDP) of the U.S. Department of Defense (RC-1542), Maranhao State Research Foundation (FAPEMA 03135/13, 02471/17), Coordination for the Improvement of Higher Education Personnel (CAPES 3281/2013), Ministry of Education, Youth and Sports of the Czech Republic (LTT17033), Colorado Wheat Research Foundation, Zone Atelier Alpes, French National Research Agency (ANR-11-BSV7-0020, ANR-09-STRA-0002, ANR 06 BIODIV 0009), Austrian Science Fund (P16027, T441), Landwirtschaftliche Rentenbank Frankfurt am Main, Welsh Government and the European Agricultural Fund for Rural Development (Project Ref. A AAB 62 03 qA731606), SEPAQ, Ministry of Agriculture and Forestry of Finland, Science Foundation Ireland (EEB0061), University of Toronto (Faculty of Forestry), National Science and Engineering Research Council of Canada, Haliburton Forest & Wildlife Reserve, NKU College of Arts & Sciences Grant, osterreichische Forschungsforderungsgesellschaft (837393 and 837426), Mountain Agriculture Research Unit of the University of Innsbruck, Higher Education Commission of Pakistan, Kerala Forest Research Institute, Peechi, Kerala, UNEP/GEF/TSBF-CIAT Project on Conservation and Sustainable Management of Belowground Biodiversity, Ministry of Agriculture and Forestry of Finland, Complutense University of Madrid/European Union FP7 project BioBio (FPU UCM 613520), GRDC, AWI, LWRRDC, DRDC, CONICET (National Scientific and Technical Research Council) and FONCyT (National Agency of Scientific and Technological Promotion) (PICT, PAE, PIP), Universidad Nacional de Lujan y FONCyT (PICT 2293 (2006)), Fonds de recherche sur la nature et les technologies du Quebec (131894), Deutsche Forschungsgemeinschaft (SCHR1000/3-1, SCHR1000/6-1, 6-2 (FOR 1598), WO 670/7-1, WO 670/7-2, & SCHA 1719/1-2), CONACYT (FONDOS MIXTOS TABASCO/PROYECTO11316), NSF (DGE-0549245, DGE-0549245, DEB-BE-0909452, NSF1241932, LTER Program DEB-97-14835), Institute for Environmental Science and Policy at the University of Illinois at Chicago, Dean's Scholar Program at UIC, Garden Club of America Zone VI Fellowship in Urban Forestry from the Casey Tree Endowment Fund, J.E. Weaver Competitive Grant from the Nebraska Chapter of The Nature Conservancy, The College of Liberal Arts and Sciences at Depaul University, Elmore Hadley Award for Research in Ecology and Evolution from the UIC Dept. of Biological Sciences, Spanish CICYT (AMB96-1161, REN2000-0783/GLO, REN2003-05553/GLO, REN2003-03989/GLO, CGL2007-60661/BOS), Yokohama National University, MEXT KAKENHI (25220104), Japan Society for the Promotion of Science KAKENHI (25281053, 17KT0074, 25252026), ADEME (0775C0035), Ministry of Science, Innovation and Universities of Spain (CGL2017-86926-P), Syngenta Philippines, UPSTREAM, LTSER (Val Mazia/Matschertal), Marie Sklodowska Curie Postdoctoral Fellowship (747607), National Science & Technology Base Resource Survey Project of China (2018FY100306), McKnight Foundation (14-168), Program of Fundamental Researches of Presidium of Russian Academy of Sciences (AAAA-A18-118021490070-5), Brazilian National Council for Scientific and Technological Development (CNPq 310690/2017-0, 404191/2019-3, 307486/2013-3), French Ministry of Foreign and European Affairs, Bavarian Ministry for Food, Agriculture and Forestry (Project No B62), INRA AIDY project, MIUR PRIN 2008, Idaho Agricultural Experiment Station, Estonian Science Foundation, Ontario Ministry of the Environment, Canada, Russian Science Foundation (16-17-10284), National Natural Science Foundation of China (41371270), Australian Research Council (FT120100463), USDA Forest Service-IITF. Open Access funding enabled and organized by Projekt DEAL., ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010), ANR-11-BSV7-0020,METABAR,Metacode-barre ADN pour une nouvelle génération de suivi de la biodiversité(2011), ANR-09-STRA-0002,FORGECO,Du diagnostic à l'action: créer les conditions d'une gestion integrée et viable des écosystèmes forestiers sur les territoires(2009), ANR-06-BDIV-0009,AMAZ_BD,Biodiversité des paysages amazoniens. Déterminants socio-économiques et productio de biens et services écosystèmiques(2006), European Project: 677232,H2020,ERC-2015-STG,ECOWORM(2016), European Project: 323020,EC:FP7:ERC,ERC-2012-ADG_20120314,SPECIALS(2013), European Project: 265171,EC:FP7:ENV,FP7-ENV-2010,FUNDIVEUROPE(2010), European Project: 265156,EC:FP7:ENV,FP7-ENV-2010,ROUTES(2011), European Project: ERC-2015-AdG 694368, European Project: 227161,EC:FP7:KBBE,FP7-KBBE-2008-2B,BIOBIO(2009), Terrestrial Ecology (TE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Department of Natural Resources & The Environment [CALS], College of Agriculture and Life Sciences [Cornell University] (CALS), Cornell University [New York]-Cornell University [New York], Department of Entomology [CALS], Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Universiteit Gent = Ghent University (UGENT), Kyushu University, Universidad de Extremadura - University of Extremadura (UEX), Adaptation et diversité en milieu marin (ADMM), Institut national des sciences de l'Univers (INSU - CNRS)-Station biologique de Roscoff (SBR), Faculty of Biological and Environmental Sciences, Organismal and Evolutionary Biology Research Programme, Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa. ISFOOD - Institute for Innovation and Sustainable Development in Food Chain, Universidad Pública de Navarra. Departamento de Ciencias, Nafarroako Unibertsitate Publikoa. Zientziak Saila, Global Soil Biodiversity Initiative and School of Global Environmental Sustainability, Colorado State University, Universidade Positivo, Senckenberg Museum for Natural History Görlitz, Department of Soil Zoology, Université Paul-Valéry - Montpellier 3 (UPVM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Station d'écologie théorique et expérimentale (SETE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), University of Göttingen - Georg-August-Universität Göttingen, Centre of Biodiversity and Sustainable Land Use, Department of Silviculture and Forest Ecology of the Temperate Zones, Georg-August-University [Göttingen], Faculty of Forest Sciences and Forest Ecology, Institute for Agro-Environmental Sciences, Rwanda Institute for Conservation Agriculture (RICA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), UCD School of Biology & Environmental Science, UCD Earth Institute, University College Dublin, School of Agriculture, Food and Wine, Waite Research Institute, Faculty of Forestry, University of Toronto, Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Centre National de la Recherche Scientifique (CNRS), Aberystwyth University, Odum School of Ecology, Department of Biological Sciences, SUNY Cortland, Yale School Forestry & Environment Studies, Ciencias Básicas, Instituto de Ecología y Desarrollo Sustentable -INEDES, Universidad Nacional de Lujan, Université Nangui Abrogoua, Tarbiat Modaras University, AGROCAMPUS OUEST, Oklahoma State University [Stillwater], Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Centre International de Hautes Etudes Agronomiques Méditerranéennes - Institut Agronomique Méditerranéen de Montpellier (CIHEAM-IAMM), Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Centre International de Hautes Études Agronomiques Méditerranéennes (CIHEAM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Department of Animal Biology (Zoology area), Science Faculty, University of La Laguna, University of California, Justus-Liebig-University [Gießen, Germany], University of Helsinki, HELEN R. P. PHILLIPS, German Centre for Integrative Biodiversity Research, ERIN K. CAMERON, Saint Mary’s University, NICO EISENHAUER, German Centre for Integrative Biodiversity Research, Leipzig University., Wageningen University, JOSÉ ANTONIO TALAVERA, University of La Laguna, DOLORES TRIGO, University Complutense of Madrid, JIRO TSUKAMOTO, Kochi University, SHEILA URIBE-LÓPEZ, Juárez Autonomous University of Tabasco, ANNE W. DE VALENÇA, Unit Food & Agriculture, WWF-Netherlands, IÑIGO VIRTO, Universidad Pública de Navarra, ADRIAN A. WACKETT, University of Minnesota, MATTHEW W. WARREN, Earth Innovation Institute, WEIXIN ZHANG, Henan University, DANIEL CLUZEAU, Université de Rennes, ANJA COORS, ECT Oekotoxikologie GmbH, FELICITY V. CROTTY, Aberystwyth Universtiy, Royal Agricultural University, JASMINE M. CRUMSEY, University of Georgia, Saint Marys University, ELIZABETH M. BACH, Colorado State University, MARIE L. C. BARTZ, Universidade Positivo, University of Coimbra, JOANNE M. BENNETT, German Centre for Integrative Biodiversity Research, Martin Luther University Halle-Wittenberg, RÉMY BEUGNON, German Centre for Integrative Biodiversity Research, MARIA J. I. BRIONES, Universidad de Vigo, GEORGE GARDNER BROWN, CNPF, OLGA FERLIAN, German Centre for Integrative Biodiversity Research, KONSTANTIN B. GONGALSKY, Russian Academy of Sciences, Lomonosov Moscow State University, CARLOS A. GUERRA, German Centre for Integrative Biodiversity Research, BIRGITTA KÖNIG-RIES, German Centre for Integrative Biodiversity Research, Friedrich Schiller University, JULIA J. KREBS, German Centre for Integrative Biodiversity Research, ALBERTO ORGIAZZI, European Commission, Joint Research Centre, KELLY S. RAMIREZ, Netherlands Institute of Ecology, DAVID J. RUSSELL, Senckenberg Museum for Natural History Görlitz, BENJAMIN SCHWARZ, University of Freiburg, DIANA H. WALL, Colorado State University, ULRICH BROSE, German Centre for Integrative Biodiversity Research, Friedrich Schiller University Jena, THIBAUD DECAËNS, Univ Paul Valéry Montpellier, PATRICK LAVELLE, Institut d’Ecologie et des Sciences de l’Environnement, MICHEL LOREAU, Theoretical and Experimental Ecology Station, JÉRÔME MATHIEU, Institute of Ecology and Environmental Sciences of Paris, Institut d’Ecologie et des Sciences de l’Environnement de Paris, CHRISTIAN MULDER, University of Catania, WIM H. VAN DER PUTTEN, Netherlands Institute of Ecology, MATTHIAS C. RILLIG, Freie Universität Berlin, MADHAV P. THAKUR, Netherlands Institute of Ecology, FRANCISKA T. DE VRIES, University of Amsterdam, DAVID A. WARDLE, Nanyang Technological University, CHRISTIAN AMMER, University of Göttingen, SABINE AMMER, University of Göttingen, MIWA ARAI, National Agriculture and Food Research Organization, FREDRICK O. AYUKE, University of Nairobi, Rwanda Institute for Conservation Agriculture, GEOFF H. BAKER, Health & Biosecurity, DILMAR BARETTA, Santa Catarina State University, DIETMAR BARKUSKY, Leibniz Centre for Agricultural Landscape Research, ROBIN BEAUSÉJOUR, Université de Sherbrooke, JOSE C. BEDANO, National University of Rio Cuarto, KLAUS BIRKHOFER, Brandenburg University of Technology, ERIC BLANCHART, Institut Agro, BERND BLOSSEY, Cornell University, THOMAS BOLGER, University College Dublin, ROBERT L. BRADLEY, Université de Sherbrooke, MICHEL BROSSARD, Institut Agro, JAMES C. BURTIS, Cornell University, YVAN CAPOWIEZ, Site Agroparc, TIMOTHY R. CAVAGNARO, The University of Adelaide, AMY CHOI, University of Toronto, JULIA CLAUSE, Université de Poitiers, ANDREA DÁVALOS, SUNY Cortland, DARÍO J. DÍAZ COSÍN, University Complutense of Madrid, ANNISE M. DOBSON, Yale University, ANAHÍ DOMÍNGUEZ, National University of Rio Cuarto, ANDRÉS ESTEBAN DUHOUR, Universidad Nacional de Luján, NICK VAN EEKEREN, Louis Bolk Institute, CHRISTOPH EMMERLING, University of Trier, LILIANA B. FALCO, Universidad Nacional de Luján, ROSA FERNÁNDEZ, Institute of Evolutionary Biology, STEVEN J. FONTE, Colorado State University, CARLOS FRAGOSO, Institute of Ecology A.C., ANDRÉ L. C. FRANCO, Colorado State University, ABEGAIL FUSILERO, University of the Philippines Mindanao, Ghent University, ANNA P. GERASKINA, Center for Forest Ecology and Productivity RAS, SHAIESTE GHOLAMI, Razi University, GRIZELLE GONZÁLEZ, International Institute of Tropical Forestry, MICHAEL J. GUNDALE, Swedish University of Agricultural Sciences, MÓNICA GUTIÉRREZ LÓPEZ, University Complutense of Madrid, BRANIMIR K. HACKENBERGER, University of Osijek, DAVORKA K. HACKENBERGER, University of Osijek, LUIS M. HERNÁNDEZ, Maranhão State University, JEFF R. HIRTH, Department of Jobs, Precincts and Regions, Agriculture Victoria, TAKUO HISHI, Kyushu University, ANDREW R. HOLDSWORTH, Minnesota Pollution Control Agency, MARTIN HOLMSTRUP, Aarhus University, KRISTINE N. HOPFENSPERGER, Northern Kentucky University, ESPERANZA HUERTA LWANGA, El Colegio de la Frontera Sur, Wageningen University & Research, VEIKKO HUHTA, University of Jyväskylä, TUNSISA T. HURISSO, Colorado State University, Lincoln University of Missouri, BASIL V. IANNONE III, University of Florida, MADALINA IORDACHE, University of Agricultural Sciences and Veterinary Medicine of Banat 'King Michael the 1st of Romania', ULRICH IRMLER, University of Kiel, MARI IVASK, Tallinn University of Technology, JUAN B. JESÚS, University Complutense of Madrid, JODI L. JOHNSON-MAYNARD, University of Idaho, MONIKA JOSCHKO, Leibniz Centre for Agricultural Landscape Research, NOBUHIRO KANEKO, Fukushima University, RADOSLAVA KANIANSKA, Matej Bel University, AIDAN M. KEITH, Leibniz Centre for Agricultural Landscape Research, MARIA L. KERNECKER, Leibniz Centre for Agricultural Landscape Research, ARMAND W. KONÉ, Université Nangui Abrogoua, YAHYA KOOCH, Tarbiat Modares University, SANNA T. KUKKONEN, Natural Resources Institute Finland, H. LALTHANZARA, Pachhunga University College, DANIEL R. LAMMEL, Freie Universität Berlin, IURII M. LEBEDEV, Russian Academy of Sciences, M.V. Lomonosov Moscow State University, Skolkovo Institute of Science and Technology, EDITH LE CADRE, Institut Agro, NOA K. LINCOLN, University of Hawai’i at Manoa, DANILO LÓPEZ-HERNÁNDEZ, Universidad Central de Venezuela, SCOTT R. LOSS, Oklahoma State University, RAPHAEL MARICHAL, Univ Montpellier, RADIM MATULA, Czech University of Life Sciences Prague, YUKIO MINAMIYA, Tochigi Prefectural Museum, JAN HENDRIK MOOS, Thuenen-Institute of Biodiversity, GERARDO MORENO, University of Extremadura, ALEJANDRO MORÓN-RÍOS, El Colegio de la Frontera Sur, HASEGAWA MOTOHIRO, Doshisha University, BART MUYS, Department of Earth & Environmental Sciences, Division of Forest, Nature and Landscape, JOHAN NEIRYNCK, Research Institute for Nature and Forest, LINDSEY NORGROVE, Bern University of Applied Sciences, MARTA NOVO, University Complutense of Madrid, VISA NUUTINEN, Natural Resources Institute Finland, VICTORIA NUZZO, Natural Area Consultants, P. MUJEEB RAHMAN, PSMO College, JOHAN PANSU, CSIRO Ocean and Atmosphere, Sorbonne Université, SHISHIR PAUDEL, Oklahoma State University, Phipps Conservatory and Botanical Gardens, GUÉNOLA PÉRÈS, CNRS-Université de Rennes, Institut Agro, LORENZO PÉREZ CAMACHO, University of Alcalá, JEAN-FRANÇOIS PONGE, Muséum National d’Histoire Naturelle, JÖRG PRIETZEL, Technical University of Munich, IRINA B. RAPOPORT, Russian Academy of Sciences, MUHAMMAD IMTIAZ RASHID, King Abdulaziz University, SALVADOR REBOLLO, University of Alcalá, MIGUEL Á. RODRÍGUEZ, University of Alcalá, ALEXANDER M. ROTH, University of Minnesot, Friends of the Mississippi River, GUILLAUME X. ROUSSEAU, Maranhão State University, Federal University of Maranhão, ANNA ROZEN, University of Wisconsin, EHSAN SAYAD, Razi University, LOES VAN SCHAIK, Wageningen University & Research, BRYANT SCHARENBROCH, University of Wisconsin, MICHAEL SCHIRRMANN, Leibniz Institute for Agricultural Engineering and Bioeconomy, OLAF SCHMIDT, University College Dublin, Agriculture and Food Science Centre, BORIS SCHRÖDER, Technische Universität Braunschweig, JULIA SEEBER, University of Innsbruck, MAXIM P. SHASHKOV, Russian Academy of Sciences, JASWINDER SINGH, Khalsa College Amritsar, SANDY M. SMITH, University of Toronto, MICHAEL STEINWANDTER, Institute for Alpine Environment, KATALIN SZLAVECZ, Johns Hopkins University, EMILY R. WEBSTER, University of California, NATHANIEL H. WEHR, University of Hawaii, JOANN K. WHALEN, Natural Resource Sciences, McGill University, MICHAEL B. WIRONEN, The Nature Conservancy, VOLKMAR WOLTERS, Animal Ecology, Justus Liebig University, PENGFEI WU, Southwest Minzu University, IRINA V. ZENKOVA, Institute of North Industrial Ecology Problems, Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), and Technical University of Munich (TUM)
Subjects: Data Descriptor, Distribuição Geográfica, Plan_S-Compliant-OA, Soil, Biomass, biodiversity, Diversity, Ecology, Biodiversidade, Biodiversity, eliöyhteisöt, maaperäeliöstö, PE&RC, Computer Science Applications, Multidisciplinary Sciences, Biogeography, international, 1181 Ecology, evolutionary biology, Ecosystem engineers, Science & Technology - Other Topics, Statistics, Probability and Uncertainty, Information Systems, Statistics and Probability, lierot, Science, Invertebrados, Library and Information Sciences, [SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study, Ecology and Environment, Education, eliömaantiede, [SDV.EE.ECO]Life Sciences [q-bio]/Ecology, environment/Ecosystems, Minhoca, Serviço ambiental, BIODIVERSITY CHANGE, Life Science, Ecosystem services, Earthworms, Datasets, Animals, Spatial distribution, Community ecology, Oligochaeta, Laboratorium voor Nematologie, Ecosystem, 1172 Environmental sciences, biogeography, Science & Technology, LAND-USE, Biology and Life Sciences, PLATFORM, Bodemfysica en Landbeheer, Ecología, Ecossistema, biodiversiteetti, Soil Physics and Land Management, Solo, Biologia do Solo, maaperäeläimistö, 570 Life sciences, biology, eartworm, abundance, biomass, diversity, Laboratory of Nematology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, COMMUNITIES, community ecology
Abstract: Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ecological groups. This global dataset contains 10,840 sites, with 184 species, from 60 countries and all continents except Antarctica. The data were obtained from 182 published articles, published between 1973 and 2017, and 17 unpublished datasets. Amalgamating data into a single global database will assist researchers in investigating and answering a wide variety of pressing questions, for example, jointly assessing aboveground and belowground biodiversity distributions and drivers of biodiversity change., Measurement(s) earthworm communities • Abundance • organic material • Diversity • environmental properties Technology Type(s) digital curation Factor Type(s) location Sample Characteristic - Organism Lumbricina Sample Characteristic - Environment soil Sample Characteristic - Location global Machine-accessible metadata file describing the reported data: 10.6084/m9.figshare.13399118
Published: 2021
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36. Insect-Inspired Robots: Bridging Biological and Artificial Systems

Author: Ilya Brodoline, Julien Dupeyroux, Xiaofeng Xiong, Poramate Manoonpong, Julien Serres, Stéphane Viollet, Luca Patané, Paolo Arena, University of Southern Denmark (SDU), Vidyasirimedhi Institute of Science and Technology, University of Messina, Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU), Delft University of Technology (TU Delft), Centre National de la Recherche Scientifique (CNRS), University of Catania [Italy], This work was funded with the help of the Centre National de la Recherche Scientifique (CNRS) in the framework of the MiMiC-ANT project subsidized by the PEPS INSIS 2020 'Ingénierieinspirée par la nature' program. P.M. acknowledges support from the Human Frontier Science Program under grant agreement no. RGP0002/2017, from Vidyasirimedhi Institute of Science andTechnology (VISTEC) research funding on Bio-inspired Robotics. X.X. acknowledges support from the Brødrene Hartmanns and Thomas B. Thriges under grant agreements A36775 and 7648-2106., Vidyasirimedhi Institute of Science and Technology [Thaïlande] (VISTEC), and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: biomimetism, Bionics, biomimicry, Insecta, This review article aims to address common research questions in hexapod robotics. How can we build intelligent autonomous hexapod robots that can exploit their biomechanics, This review article aims to address common research questions in hexapod robotics. How can we build intelligent autonomous hexapod robots that can exploit their biomechanics, morphology, and computational systems, to achieve autonomy, adaptability, and energy efficiency comparable to small living creatures, such as insects? Are insects good models for building such intelligent hexapod robots because they are the only animals with six legs? This review article is divided into three main sections to address these questions, as well as to assist roboticists in identifying relevant and future directions in the field of hexapod robotics over the next decade. After an introduction in section (1), the sections will respectively cover the following three key areas: (2) biomechanics focused on the design of smart legs, (3) locomotion control, and (4) high-level cognition control. These interconnected and interdependent areas are all crucial to improving the level of performance of hexapod robotics in terms of energy efficiency, terrain adaptability, autonomy, and operational range. We will also discuss how the next generation of bioroboticists will be able to transfer knowledge from biology to robotics and vice versa, such as insects? Are insects good models for building such intelligent hexapod robots because they are the only animals with six legs? This review article is divided into three main sections to address these questions, Review, Biochemistry, Field (computer science), Biomimetism, Analytical Chemistry, [SPI]Engineering Sciences [physics], 0302 clinical medicine, Human–computer interaction, morphology, as well as to assist roboticists in identifying relevant and future directions in the field of hexapod robotics over the next decade. After an introduction in section (1), Instrumentation, media_common, 0303 health sciences, Robotics, Legged robotics, Atomic and Molecular Physics, and Optics, Biomechanical Phenomena, and computational systems, and energy efficiency comparable to small living creatures, biorobotics, to achieve autonomy, legged robotics, Locomotion, Exploit, and (4) high-level cognition control. These interconnected and interdependent areas are all crucial to improving the level of performance of hexapod robotics in terms of energy efficiency, media_common.quotation_subject, terrain adaptability, TP1-1185, hexapod, Adaptability, [SPI.AUTO]Engineering Sciences [physics]/Automatic, Biomimicry, Biorobotics, Hexapod, 03 medical and health sciences, the sections will respectively cover the following three key areas: (2) biomechanics focused on the design of smart legs, Animals, Electrical and Electronic Engineering, autonomy, 030304 developmental biology, business.industry, Chemical technology, [SCCO.NEUR]Cognitive science/Neuroscience, adaptability, and operational range. We will also discuss how the next generation of bioroboticists will be able to transfer knowledge from biology to robotics and vice versa, Robot, Artificial intelligence, bionics, business, 030217 neurology & neurosurgery
Abstract: International audience; This review article aims to address common research questions in hexapod robotics. How can we build intelligent autonomous hexapod robots that can exploit their biomechanics, morphology,and computational systems, to achieve autonomy, adaptability, and energy efficiency comparable to small living creatures, such as insects? Are insects good models for building such intelligenthexapod robots because they are the only animals with six legs? This review article is divided into three main sections to address these questions, as well as to assist roboticists in identifying relevant and future directions in the field of hexapod robotics over the next decade. After an introduction in section (1), the sections will respectively cover the following three key areas: (2) biomechanics focused on the design of smart legs; (3) locomotion control; and (4) high-level cognition control. These interconnected and interdependent areas are all crucial to improving the level of performance ofhexapod robotics in terms of energy efficiency, terrain adaptability, autonomy, and operational range. We will also discuss how the next generation of bioroboticists will be able to transfer knowledge from biology to robotics and vice versa.
Published: 2021
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37. Recent advances toward the sustainable management of invasive Xylosandrus ambrosia beetles

Author: You Li, Daniel Carrillo, Davide Rassati, Nicolas Meurisse, J.P. Egonyu, Christopher M. Ranger, Peter H. W. Biedermann, Antonio Biondi, Louela A. Castrillo, Lukasz L. Stelinski, Hisashi Kajimura, Antonio Gugliuzzo, Naoto Kamata, Jason B. Oliver, Roanne Sutherland, Jiri Hulcr, Khalid Haddi, Giovanna Tropea Garzia, Hervé Jactel, Mark G. Wright, D. Gallego, Universidad de Alicante. Departamento de Ecología, University of Catania [Italy], University of Freiburg [Freiburg], University of Florida [Gainesville] (UF), United States Department of Agriculture (USDA), International Centre of Insect Physiology and Ecology (ICIPE), ICIPE, Universidad de Alicante, Federal University of Lavras, Biodiversité, Gènes & Communautés (BioGeCo), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Nagoya City University [Nagoya, Japan], The University of Tokyo (UTokyo), New Zealand Forest Research Institute, SCION, Tennessee State University, USDA Agricultural Research Service [Maricopa, AZ] (USDA), DAFNAE, Universita degli Studi di Padova, and University of Hawai‘i [Mānoa] (UHM)
Subjects: 0106 biological sciences, Integrated pest management, Ambrosia fungi, Biological pest control, 010603 evolutionary biology, 01 natural sciences, Invasive species, Xyleborini, Forest health, biology, business.industry, Agroforestry, Xylosandrus compactus, fungi, Pest control, Ecología, 15. Life on land, biology.organism_classification, Scolytinae, 010602 entomology, Curculionidae, [SDE]Environmental Sciences, business, Agronomy and Crop Science
Abstract: We provide an overview of both traditional and innovative control tools for management of three Xylosandrus ambrosia beetles (Coleoptera: Curculionidae: Scolytinae), invasive species with a history of damage in forests, nurseries, orchards and urban areas. Xylosandrus compactus, X. crassiusculus and X. germanus are native to Asia, and currently established in several countries around the globe. Adult females bore galleries into the plant xylem inoculating mutualistic ambrosia fungi that serve as food source for the developing progeny. Tunneling activity results in chewed wood extrusion from entry holes, sap outflow, foliage wilting followed by canopy dieback, and branch and trunk necrosis. Maintaining plant health by reducing physiological stress is the first recommendation for long-term control. Baited traps, ethanol-treated bolts, trap logs and trap trees of selected species can be used to monitor Xylosandrus species. Conventional pest control methods are mostly ineffective against Xylosandrus beetles because of the pests’ broad host range and rapid spread. Due to challenges with conventional control, more innovative control approaches are being tested, such as the optimization of the push–pull strategy based on specific attractant and repellent combinations, or the use of insecticide-treated netting. Biological control based on the release of entomopathogenic and mycoparasitic fungi, as well as the use of antagonistic bacteria, has yielded promising results. However, these technologies still require validation in real field conditions. Overall, we suggest that management efforts should primarily focus on reducing plant stress and potentially be combined with a multi-faceted approach for controlling Xylosandrus damage. This research was supported by the University of Catania (Project Emergent Pests and Pathogens and Relative Sustainable Strategies - 5A722192113; PhD fellowship to AG). P.H.W.B. was supported by the German Research Foundation (DFG Emmy Noether Grant BI 1956/1–1). Funding to MGW: USDA-NIFA, ARS and APHIS; ISDA Hatch; Hawaii Dept. of Agriculture. JH and YL were funded by the USDA APHIS and USDA Forest Service. HK was partially supported by Japan Society for the Promotion of Science (Grant-in-Aid for Scientific Research, KAKENHI, Nos. 18KK0180, 19H02994 and 20H03026). KH was partially supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes, Brazil; Finance code 001). Open access funding provided by Università degli Studi di Catania within the CRUI-CARE Agreement.
Published: 2021
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38. Prevalence of idiopathic REM behavior disorder: a systematic review and meta-analysis

Author: Loretta Giuliano, Alessandra Nicoletti, Pierre-Marie Preux, Mario Zappia, Jaime Luna, Calogero Edoardo Cicero, University of Catania [Italy], Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, and Université de Limoges (UNILIM)
Subjects: medicine.medical_specialty, Population, prevalence, Subgroup analysis, REM Sleep Behavior Disorder, REM sleep behavior disorder, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, Epidemiology, medicine, Humans, education, 030304 developmental biology, REM behavior disorder, 0303 health sciences, education.field_of_study, business.industry, Ecological study, medicine.disease, Confidence interval, 3. Good health, meta-analysis, Sample size determination, Meta-analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, epidemiology, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract: Study Objectives To provide an overall estimate of the prevalence of idiopathic REM Sleep Behavior Disorder (iRBD). Methods Two investigators have independently searched the PubMed and Scopus databases for population-based studies assessing the prevalence of iRBD. Data about type of diagnosis (polysomnographic diagnosis, defined iRBD [dRBD]; clinical diagnosis, probable RBD [pRBD]), continent, age range of the screened population, quality of the studies, sample size, screening questionnaires, and strategies have been gathered. A random-effect model was used to estimate the pooled prevalence. Heterogeneity was investigated with subgroup analysis and meta-regression. Results From 857 articles found in the databases, 19 articles were selected for the systematic review and meta-analysis. According to the type of diagnosis, five studies identified dRBD cases given a pooled prevalence of 0.68% (95% confidence interval [CI] 0.38–1.05) without significant heterogeneity (Cochran’s Q p = 0.11; I2 = 46.43%). Fourteen studies assessed the prevalence of pRBD with a pooled estimate of 5.65% (95% CI 4.29–7.18) and a significant heterogeneity among the studies (Cochran’s Q p < 0.001; I2 = 98.21%). At the subgroup analysis, significant differences in terms of prevalence were present according to the quality of the studies and, after removing two outlaying studies, according to the continents and the screening questionnaire used. Meta-regression did not identify any significant effect of the covariates on the pooled estimates. Conclusion Prevalence estimates of iRBD are significantly impacted by diagnostic level of certainty. Variations in pRBD prevalence are due to methodological differences in study design and screening questionnaires employed.
Published: 2021
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39. COVID-19-related echocardiographic patterns of cardiovascular dysfunction in critically ill patients: A systematic review of the current literature

Author: Katerina Negri, Filippo Sanfilippo, Angelo Milani, Marinella Astuto, Manuel Ignacio Monge García, Antonio Messina, Antoine Vieillard-Baron, Maurizio Cecconi, Lorenzo Calabrò, Humanitas University [Milan] (Hunimed), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], University of Milan, University of Catania [Italy], Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, and Hôpital Ambroise Paré [AP-HP]
Subjects: Adult, 2019-20 coronavirus outbreak, medicine.medical_specialty, Diastolic function, Coronavirus disease 2019 (COVID-19), Critical Illness, [SDV]Life Sciences [q-bio], Disease, Critical Care and Intensive Care Medicine, Article, SARS-CoV-2, severe disease with the acute respiratory syndrome, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, EF, ejection fraction, Medicine, Prospective Studies, Trial registration, Retrospective Studies, COVID-19, coronavirus disease 2019, GLS, global longitudinal strain, Ejection fraction, SARS-CoV-2, business.industry, Critically ill, Systolic function, COVID-19, 030208 emergency & critical care medicine, Retrospective cohort study, Left ventricle, ICU, intensive care unit, 3. Good health, RV, right ventricle, Critical care, LV, left ventricle, 030228 respiratory system, Sample size determination, Echocardiography, TAPSE, Tricuspid Annular Plane Systolic Excursion, Right ventricle, business
Abstract: International audience; Purpose: Coronavirus disease 2019 (COVID-19) infection may trigger a multi-systemic disease involving different organs. There has been growing interest regarding the harmful effects of COVID-19 on the cardiovascular system. This systematic review aims to systematically analyze papers reporting echocardiographic findings in hospitalized COVID-19 subjects. Materials and methods: We included prospective and retrospective studies reporting echocardiography data in >10 hospitalized adult subjects with COVID-19; from 1st February 2020 to 15th January 2021. Results: The primary electronic search identified 1120 articles. Twenty-nine studies were finally included, enrolling 3944 subjects. Overall the studies included a median of 68.0% (45.5–100.0) of patients admitted to ICU. Ten studies (34.4%) were retrospective, and 20 (68.9%) single-centred. Overall enrolling 1367 subjects, three studies reported normal echocardiographic findings in 49 ± 18% of cases. Seven studies (24.1%) analyzed the association between echocardiographic findings and mortality, mostly related to right ventricular (RV) dysfunction. Conclusions: Data regarding the use of echocardiography on hospitalized, predominantly ICU, COVID-19 patients were retrieved from studies with heterogeneous designs, variable sample sizes, and severity scores. Normal echocardiographic findings were reported in about 50% of subjects, with LVEF usually not affected. Overall, RV dysfunction seems more likely associated with increased mortality. Trial Registration: CRD42020218439.
Published: 2021
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40. Impact of stent thickness on clinical outcomes in small vessel and bifurcation lesions: a RAIN-CARDIOGROUP VII sub-study

Author: Ovidio De Filippo, Wojciech Wańha, Satoru Mitomo, Nicola Ryan, Radosław Parma, Imad Sheiban, Luca Franchin, Giuseppe Venuti, Bernardo Cortese, Francesco Piroli, Gérard Helft, Iván J. Núñez-Gil, Andrea Montabone, Andrea Rognoni, Saverio Muscoli, Yoichi Imori, Zenon Huczek, Giorgio Quadri, Ferdinando Varbella, Daniela Trabattoni, Gaetano M. De Ferrari, Fabrizio D'Ascenzo, Wojciech Wojakowski, Filippo Figini, Università degli studi di Torino = University of Turin (UNITO), Clínico San Carlos University Hospital, Medical University of Silesia (SUM), Nippon Medical School [Tokyo, Japon], Centro Cardiologico Monzino [Milano], Dpt di Scienze Cliniche e di Comunità [Milano] (DISCCO), Università degli Studi di Milano = University of Milan (UNIMI)-Università degli Studi di Milano = University of Milan (UNIMI)-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Medical University of Warsaw - Poland, AOU Policlinico Vittorio-Emanuele [Catania, Italia], University of Catania [Italy], Department of Public Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy, Ospedale San Giovanni Bosco [Turin, Italy] (OSGB), University Hospital 'Maggiore della Carità' [Novara, Italy], Clinica Pederzoli [Peschiera del Garda, Italy] (CP), IRCCS Ospedale San Raffaele [Milan, Italy], Ospedale 'Infermi' di Rimini [Rimini, Italy] (OIR), Azienda Ospedaliero-Universitaria San Luigi Gonzaga/San Luigi Gonzaga University Hospital (SLGUH), Clinica San Carlo [Milan, Italy] (CSC), Institut de cardiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Lesnik, Philippe
Subjects: Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Population, Coronary Artery Disease, 030204 cardiovascular system & hematology, Prosthesis Design, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Risk Factors, Internal medicine, medicine, Clinical endpoint, Humans, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, education, Aged, Retrospective Studies, Aged, 80 and over, education.field_of_study, business.industry, Coronary Thrombosis, Hazard ratio, Stent, General Medicine, Middle Aged, medicine.disease, [SDV] Life Sciences [q-bio], Treatment Outcome, Italy, Conventional PCI, Cardiology, Female, Stents, Small vessel, Cardiology and Cardiovascular Medicine, business, Mace
Abstract: Background The clinical impact of stent strut thickness in coronary bifurcation lesions in small vessels has not been assessed in a real-world population. Methods and results All 506 patients enrolled in the RAIN study, undergoing PCI in a vessel with a diameter 2.5 mm or less were retrospectively evaluated and divided into two groups according to stent strut thickness: 74 μm (n = 206) versus 81 μm (n = 300); 87.1% of the lesions involved bifurcations. TLF [defined as a composite of myocardial infarction (MI) and target lesion revascularization (TLR)] was the primary endpoint, with MACE (a composite of death, MI and TLR), its components and stent thrombosis the secondary endpoint. After 16 (14-18) months, a lower incidence of TLF (4.3 vs. 9.8%, P = 0.026) and ST (1.0 vs. 3.0%, P = 0.042) was seen in the 74 μm group, whereas MACE occurred in 60 of 506 patients, with no statistical difference between the two groups (9.7 vs. 13.3%, P = 0.070). At multivariate analysis, chronic renal failure increased the risk of TLF while thinner strut was an independent protective factor (hazard ratio 0.51, CI 0.17-0.85, P = 0.005). Conclusion In this real-world population, patients being treated for small vessels lesions with thinner strut stents had lower rates of TLF, MI and ST.
Published: 2021
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41. Thermal biology of Tuta absoluta: demographic parameters and facultative diapause

Author: Nicolas Desneux, Abhijin Adiga, Philippe Béarez, Luigi Ponti, Andrew Paul Gutierrez, Antonio Biondi, Edwige Amiens-Desneux, Mateus R. Campos, de Campos, M. R., Bearez, P., Amiens-Desneux, E., Ponti, L., Gutierrez, A. P., Biondi, A., Adiga, A., Desneux, N., Institut Sophia Agrobiotech (ISA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Côte d'Azur (UCA), Casaccia Research Center, Department of Agricultural and Forest Systems Management - Center for the Analysis of Sustainable Agro-ecological Systems, Università della Calabria [Arcavacata di Rende] (Unical), University of California [Berkeley] (UC Berkeley), University of California (UC), University of Catania [Italy], University of Virginia, Project ASCII (FP7 IRSES) 318246, University of Catania 5A722192113, United States Agency for International Development (USAID) AID-OAA-L-15-00001, Center for Sustainable Agricultural Systems, Kensington, CA, USA, European Project: 633999, European Project: 776467,MED-GOLD, Université Nice Sophia Antipolis (... - 2019) (UNS), Università degli Studi della Calabria, University of California [Berkeley], University of California, and University of Virginia [Charlottesville]
Subjects: 0106 biological sciences, Invasive pest, Entomology, Facultative, Phenotypic plasticity, Larva, fungi, Thermal biology, Zoology, Biology, Diapause, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Pupa, 010602 entomology, [SDE]Environmental Sciences, Geographic variation, Tuta absoluta, Temperature thresholds, PEST analysis, Agronomy and Crop Science
Abstract: International audience; The South American tomato pinworm,Tuta absoluta, (SATP) is now a devastating pest worldwide of crops in the family Solanaceae. Most prior studies of SATP's thermal biology were based on populations from tropical regions, and proved unsuitable for explaining its invasion of large areas of the Palearctic. A more holistic approach to the analysis of its thermal biology is essential background for developing models to assess its invasive potential. Our studies found that SATP has lower and upper thermal thresholds(theta(L) = 5.37 degrees C and theta(U)= 35.69 degrees C, respectively) than South American populations used in prior studies (theta(L)= 7.38 degrees C and theta(U)= 33.82 degrees C). Age-specific life tables were used to estimate the effects of temperature on its demographic parameters. Diapause in SATP had not been characterized prior to our study. We found facultative diapause in pupae developing from larvae exposed to relatively low temperatures (i.e., 2 and 5 degrees C) and short-day length for different exposure periods. The strength of diapause was measured as an increase in post-treatment developmental times of pupae (i.e., degree days) that on average were 2.45-3-fold greater than of pupae reared at favorable temperatures. A lower developmental threshold and a facultative diapause increase the invasive potential of SATP in temperate areas. Knowledge of this thermal biology is essential for predicting the potential geographic spread of this pest and to develop management and control strategies.
Published: 2021
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42. Sperm Vitality and Necrozoospermia: Diagnosis, Management, and Results of a Global Survey of Clinical Practice

Author: Yoshiharu Morimoto, Kasonde Bowa, Israel Maldonado Rosas, Marjan Sabbaghian, Ralf Henkel, Juan Manuel Corral Molina, Chak-Lam Cho, Kristian Leisegang, Hisanori Taniguchi, Mohamed Ali Sadighi Gilani, Germar-Michael Pinggera, Sunil Jindal, Christopher Chee Kong Ho, Gianmaria Salvio, Marlon Martinez, Juan Carlos Alvarez, Taha A. Abdel-Meguid, Jean de la Rosette, Taymour Mostafa, Mohamed S. Al-Marhoon, Sava Micic, Ashok Agarwal, Jonathan Ramsay, Samantha B. Schon, Ala'a Farkouh, Kareim Khalafalla, Gian Maria Busetto, Nicholas N. Tadros, Sajal Gupta, Edoardo Pescatori, Gökhan Çeker, Renata Finelli, Ayad Palani, Damayanthi Durairajanayagam, Marcelo Gabriel Rodriguez, Florence Boitrelle, Rupin Shah, Eric Chung, Mohamed Arafa, Ramadan A Saleh, Christina Anagnostopoulou, Shinnosuke Kuroda, Parviz Kavoussi, Shinichiro Fukuhara, Armand Zini, Giovanni M. Colpi, Paraskevi Vogiatzi, Neel Parekh, Hussein Kandil, Tan V. Le, Raghavender Kosgi, Ponco Birowo, Rossella Cannarella, Giancarlo Balercia, Mara Simopoulou, Sijo Parekattil, Ettore Caroppo, Aldo E. Calogero, Mesut Berkan Duran, Osvaldo Rajmil, Amarnath Rambhatla, Haitham Elbardisi, Hyun Jun Park, Saleem Ali Banihani, Fotios Dimitriadis, Edmund Y. Ko, Rakesh Sharma, Cleveland Clinic, CHI Poissy-Saint-Germain, Biologie de la Reproduction, Environnement, Epigénétique & Développement (BREED), École nationale vétérinaire d'Alfort (ENVA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hamad Medical Corporation [Doha, Qatar], Weill Cornell Medicine [Qatar], The Chinese University of Hong Kong [Hong Kong], Henry Ford Health System, Imperial College London, University of the Western Cape, The University of Texas at San Antonio (UTSA), Loma Linda University, Fakih IVF Fertility Center, University of Garmian, Università Politecnica delle Marche [Ancona] (UNIVPM), Cairo University - Faculty of Medicine, Fundació Puigvert [Barcelona, Spain], Jordan University of Science and Technology [Irbid, Jordan], University of Michigan Medical School [Ann Arbor], University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Pham Ngoc Thach Medical University [Ho Chi Minh city, Vietnam] (PNTUM), Faculty of Medicine [Jakarta, Indonesia], Universitas Indonesia [Jakarta, Indonesia], Taylor's University Malaysia, University of Catania [Italy], Hamad medical corporation, McGill University = Université McGill [Montréal, Canada], University of Queensland [Brisbane], Aristotle University of Thessaloniki, Innsbruck Medical University [Austria] (IMU), Università degli Studi di Foggia - University of Foggia, Kansai Medical University, Pusan National University, Hammersmith Hospital NHS Imperial College Healthcare, National and Kapodistrian University of Athens (NKUA), Royan Institute for Reproductive Biomedicine [Tehran, Iran], UNIVERSITY OF SANTO TOMAS MANILA PHL, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Sultan Qaboos University (SQU), Università degli studi di Catania [Catania], Osaka University [Osaka], University of Central Florida [Orlando] (UCF), Minia University, King Abdulaziz University, and Lilavati Hospital and Research Centre
Subjects: Aging, Vitality, 0302 clinical medicine, Pharmacology (medical), TESTICULAR SPERMATOZOA, Andrology, Sperm motility, 0303 health sciences, 030219 obstetrics & reproductive medicine, Spermatozoon, Health Policy, Urology & Nephrology, Spermatozoa, 3. Good health, Psychiatry and Mental health, medicine.anatomical_structure, Asthenozoospermia, EosineYellowish-(YS), Eosine Yellowish-(YS), Life Sciences & Biomedicine, Infertility, medicine.medical_specialty, endocrine system, Urology, Semen, ICSI, PARAMETERS, 03 medical and health sciences, Endocrinology & Metabolism, medicine, Intensive care medicine, 030304 developmental biology, Nigrosin, Science & Technology, SEMINAL PLASMA, business.industry, urogenital system, MALE-INFERTILITY, Public Health, Environmental and Occupational Health, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, medicine.disease, Sperm, VIABILITY, IMMOTILE, Health Care Sciences & Services, Reproductive Medicine, DNA-DAMAGE, SEMEN QUALITY, Etiology, business, HYPOOSMOTIC SWELLING TEST
Abstract: International audience; Sperm vitality testing is a basic semen examination that has been described in the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen from its primary edition, 40 years ago. Several methods can be used to test sperm vitality, such as the eosin-nigrosin (E-N) stain or the hypoosmotic swelling (HOS) test. In the 6th (2021) edition of the WHO Laboratory Manual, sperm vitality assessment is mainly recommended if the total motility is less than 40%. Hence, a motile spermatozoon is considered alive, however, in certain conditions an immotile spermatozoon can also be alive. Therefore, the differentiation between asthenozoospermia (pathological decrease in sperm motility) and necrozoospermia (pathological decrease in sperm vitality) is important in directing further investigation and management of infertile patients. The causes leading to necrozoospermia are diverse and can either be local or general, testicular or extra-testicular. The andrological management of necrozoospermia depends on its etiology. However, there is no standardized treatment available presently and practice varies among clinicians. In this study, we report the results of a global survey to understand current practices regarding the physician order of sperm vitality tests as well as the management practices for necrozoospermia. Laboratory and clinical scenarios are presented to guide the reader in the management of necrozoospermia with the overall objective of establishing a benchmark ranging from the diagnosis of necrozoospermia by sperm vitality testing to its clinical management.
Published: 2021
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43. New records of rare species in the Mediterranean Sea (March 2021)

Author: Santin, Andreu, Aguilar, Ricardo, AKYOL, Okan, BEGBURS, Cenkmen, BENOIT, Laure, Chimienti, Giovanni, Crocetta, Fabio, DALYAN, Cem, DE LA LINDE RUBIO, Antonio, DRAGIČEVIĆ, Branko, Dulčić, Jakov, GIGLIO, Gianni, GÖNÜLAL, Onur, KEBAPCIOGLU, Turhan, KESICI, Nur, Kiparissis, Sotiris, KOUSTENI, Vasiliki, Mancini, Emanuele, Mastrototaro, Francesco, MENUT, Thomas, Montesanto, Federica, Peristeraki, Panagiota, Poursanidis, Dimitris, Renoult, Julien, SÁNCHEZ-TOCINO, Luis, SPERONE, Emilio, TIRALONGO, Francesco, Andreu, Santin, Croatian Science Foundation, Istanbul University, Agencia Estatal de Investigación (España), Institute of Marine Sciences / Institut de Ciències del Mar [Barcelona] (ICM), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), OCEANA, Faculty of Fisheries, Ege University, Akdeniz University, Fisheries Faculty, Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Consorzio Nazionale Interuniversitario per le Scienze del Mare [Rome, Italie] (CoNISma), University of Bari Aldo Moro (UNIBA), Stazione Zoologica Anton Dohrn (SZN), Agencia del Medio Ambiente y Agua de Andalucía, Institute of Oceanography and Fisheries, Department of Biology, Ecology and Earth Sciences [Arcavacata di Rende] (DiBEST), Università della Calabria [Arcavacata di Rende] (Unical), Hellenic Centre for Marine Research (HCMR), Institute of Marine Biological Resources and Inland Waters, Hellenic Center for Marine Research (HCMR), Hellenic Agricultural Organization Demeter (HAO Demeter), National and Kapodistrian University of Athens (NKUA), University of Tuscia, Università degli studi di Bari Aldo Moro (UNIBA), Biotope [Mèze], Foundation for Research and Technology - Hellas (FORTH), Regional Analysis Division (Institute of Applied and Computational Mathematics), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), University of Granada [Granada], University of Catania [Italy], Department of Biological, Geological and Environmental Sciences, University of Catania, Ente Fauna Marina Mediterranea (EFFM), The work carried out by Giovanni Chimienti and Ricardo Aguilar was supported by the International Foundation (IF), the SmileWave Fund, the `Fondation de Bienfaisance du groupe Pictet', the Adessium Foundation, the Stiftung Drittes Millennium and the Italian Ministry of Education, University and Research (PON 2014-2020, grant AIM 1807508-1, Linea 1). Their study has been fully supported by Croatian Science Foundation (HRZZ) under the project IP -2016-06-5251. The work carried out by Onur Gonulal on Distolambrus maltzami was supported by the Scientific Research Projects of Istanbul University, (Project No. FBA-2017-23597). The contribution by Cem Dalyan and Nur Bikem Kesici on Hygophum hygomii is part of a project that was supported by the Research Fund of the Istanbul University (Project No. FBA-2019-29078)., Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Università degli studi della Tuscia [Viterbo], Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Universidad de Granada = University of Granada (UGR), and Università degli studi di Catania = University of Catania (Unict)
Subjects: Mediterranean climate, Environmental Engineering, Lamprey, biology, BIODIVERSITY, DECAPODA, LAMPREY, SPONGES, STRAIT, Taringa, [SDV]Life Sciences [q-bio], Mediterranean spearfish, Lobotes surinamensis, Biodiversity, Aquatic Science, Tripletail, Oceanography, biology.organism_classification, Belone, Mediterranean sea, Lepadogaster lepadogaster, Geography, Decapoda, Sponges, Strait, 14. Life underwater, Ecology, Evolution, Behavior and Systematics
Abstract: 19 pages, 16 figures, 3 tables, This Collective Article presents information on 17 taxa belonging to five (5) Phyla and extending from the Alboran Sea to the Levantine Sea. These new records were found in six (6) different ecoregions as follows: Alboran Sea: Second and easternmost record of the sponge Chalinula nigra in the Mediterranean Sea; Western Mediterranean: first record of the rare gobid Gobius couchi for Spain, based on both morphological and molecular data; new records for the rare ascidian Ciona edwardsi from the Marine Protected Area of Tavolara, Sardinia; several records for four (4) different species of black coral, Antipathella subpinnata, Antipathes dichotoma, Leiopathes glaberrima and Parantipathes larix from the Aeolian Archipelago, all of which are currently threatened and/or protected at a Mediterranean level; the first documented records of the sea lamprey Petromyzon marinus in Calabria, which is considered “Critically Endangered” in Italy; first record in the Tyrrhenian Sea and second record in the Ionian Sea for the crab Ocypode cursor, which seems to be rapidly expanding its distribution range across Italian waters; Adriatic Sea: Additional records of yellowmouth barracuda, Sphyraena viridensis, in the northern Adriatic, which seems to be experimenting a meridionalization process in the region; Aegean Sea: First confirmed record of the iconic gastropod Bursa scrobilator scrobilator in the eastern Mediterranean Sea; an additional record for the vulnerable shark Dalatias licha, also being the largest individual caught in eastern Mediterranean waters till the time of capture; an additional record for the rare crab Distolambrus maltzami, suggesting the species might be more morphologically variable than originally thought; first documented record for the myctophid Hygophum hygomii in both Turkish waters and the north Aegean Sea; additional records for the tuna Katsuwonus pelamis and the sunfish Ranzania laevis in the eastern Mediterranean, pointing out that both species might not be as rare in the area as previously thought; Levantine Sea: additional records for the rare stingray Taeniura grabata in Turkish waters, Their study has been fully supported by Croatian Science Foundation (HRZZ) under the project IP - 2016-06-5251. [...] The work carried out by Onur Gönülal on Distolambrus maltzami was supported by the Scientific Research Projects of Istanbul University, (Project No. FBA-2017-23597). The contribution by Cem Dalyan and Nur Bikem Kesici on Hygophum hygomii is part of a project that was supported by the Research Fund of the Istanbul University (Project No. FBA-2019-29078)., With the institutional support of the ‘Severo OchoaCentre of Excellence’ accreditation (CEX2019-000928-S)
Published: 2021
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44. Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts

Author: Mark Slee, Guillermo Izquierdo, Per Soelberg Soerensen, Karen Schreiber, Alexandre Prat, Francois Grand'Maison, Maria Trojano, Franco Granella, Pierre Duquette, David Laplaud, Elisabeth Maillart, Henrik Kahr Mathiesen, Bassem Yamout, Cavit Boz, Jean Pelletier, Corinne Pottier, Jette L. Frederiksen, Claudia Christina Pfleger, Tomas Kalincik, Olivier Gout, Daniele Spitaleri, Marc Girard, Marco Onofrj, Jérôme De Seze, Helmut Butzkueven, Emmanuelle Leray, Philippe Cabre, Julie Prevost, Abullatif Al-Khedr, Aude Maurousset, Eric Berger, Sifat Sharmin, Ivania Patry, Pamela A. McCombe, Patrizia Sola, Olga Skibina, Diana Ferraro, Pierre Clavelou, Francesco Patti, Finn Sellebjerg, Niels Koch-Henriksen, Alexis Montcuquet, Recai Turkoglu, Romain Casey, Bart Van Wijmeersch, Hélène Zéphir, Pierre Grammond, Dana Horakova, Davide Maimone, Serkan Ozakbas, Céline Labeyrie, Murat Terzi, Aurélie Ruet, Steve Vucic, Jonathan Ciron, Tünde Csépány, Nicolas Maubeuge, Bruno Stankoff, Mathilde Lefort, Katherine Buzzard, Karolina Hankiewicz, Jean-Philippe Camdessanché, Raed Alroughani, Michael Broksgaard Jensen, Pierre Labauge, Olivier Casez, Peter Vestergaard Rasmussen, Bertrand Bourre, Olivier Heinzlef, Gilles Defer, Gilles Edan, Alessandra Lugaresi, Abir Wahab, Melinda Magyari, Anneke van der Walt, Eva Havrdova, Johanna Balslev Andersen, Chantal Nifle, Stephan Bramow, Marc Debouverie, Thibault Moreau, Sandra Vukusic, Christine Lebrun-Frenay, Jeannette Lechner-Scott, Eric Thouvenot, Sharmin S., Lefort M., Andersen J.B., Leray E., Horakova D., Havrdova E.K., Alroughani R., Izquierdo G., Ozakbas S., Patti F., Onofrj M., Lugaresi A., Terzi M., Grammond P., Grand'Maison F., Yamout B., Prat A., Girard M., Duquette P., Boz C., Trojano M., McCombe P., Slee M., Lechner-Scott J., Turkoglu R., Sola P., Ferraro D., Granella F., Prevost J., Maimone D., Skibina O., Buzzard K., Van der Walt A., Van Wijmeersch B., Csepany T., Spitaleri D., Vucic S., Casey R., Debouverie M., Edan G., Ciron J., Ruet A., De Seze J., Maillart E., Zephir H., Labauge P., Defer G., Lebrun-Frenay C., Moreau T., Berger E., Clavelou P., Pelletier J., Stankoff B., Gout O., Thouvenot E., Heinzlef O., Al-Khedr A., Bourre B., Casez O., Cabre P., Montcuquet A., Wahab A., Camdessanche J.-P., Maurousset A., Patry I., Hankiewicz K., Pottier C., Maubeuge N., Labeyrie C., Nifle C., Laplaud D., Koch-Henriksen N., Sellebjerg F.T., Soerensen P.S., Pfleger C.C., Rasmussen P.V., Jensen M.B., Frederiksen J.L., Bramow S., Mathiesen H.K., Schreiber K.I., Magyari M., Vukusic S., Butzkueven H., Kalincik T., University of Melbourne, Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Copenhagen = Københavns Universitet (UCPH), École des Hautes Études en Santé Publique [EHESP] (EHESP), Charles University [Prague] (CU), Amiri hospital, Hospital Virgen Macarena, Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), University of Catania [Italy], G.F. Ingrassia Hospital, Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Institute of Neurological Science of Bologna (IRCCS), Ondokuz Mayis University (OMU), American University of Beirut Faculty of Medicine and Medical Center (AUB), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Karadeniz Technical University (KTU), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), University of Queensland [Brisbane], Royal Brisbane & Women's Hospital [Brisbane, Australia] (RBWH), Flinders University [Adelaide, Australia], University of Newcastle [Callaghan, Australia] (UoN), Azienda Ospedaleria Universitaria di Modena, Università degli studi di Parma = University of Parma (UNIPR), University Hospital Parma, Monash University [Melbourne], The Alfred Hospital, Hasselt University (UHasselt), University of Debrecen Egyetem [Debrecen], San Giuseppe Moscati Hospital [Avellino, Italie], Westmead Hospital [Sydney], Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hospices Civils de Lyon (HCL), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Fondation Eugène Devic EDMUS, Adaptation, mesure et évaluation en santé. Approches interdisciplinaires (APEMAC), Université de Lorraine (UL), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC Strasbourg (Centre d’Investigation Clinique Plurithématique (CIC - P) ), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nouvel Hôpital Civil de Strasbourg-Hôpital de Hautepierre [Strasbourg], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Lille, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Hôpital Pasteur [Nice] (CHU), Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Clermont-Ferrand, Neuro-Dol (Neuro-Dol), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), Hôpital de la Timone [CHU - APHM] (TIMONE), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CHI Poissy-Saint-Germain, Service de neurologie [Amiens], CHU Amiens-Picardie, Service de neurologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Centre Hospitalier Universitaire [Grenoble] (CHU), CHU de la Martinique [Fort de France], Service de Neurologie [CHU Limoges], CHU Limoges, CHU Henri Mondor [Créteil], Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Service de Neurologie [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau, Hôpital Sud Francilien Corbeil Essonne, Centre Hospitalier de Saint-Denis [Ile-de-France], Centre Hospitalier René Dubos [Pontoise], Hôpital de la Milétrie, Centre hospitalier universitaire de Poitiers (CHU Poitiers), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Centre Hospitalier de Versailles André Mignot (CHV), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Aarhus University Hospital, Aalborg University [Denmark] (AAU), University Hospital of Northern Sealand, Rigshospitalet [Copenhagen], Copenhagen University Hospital, The Royal Melbourne Hospital, 1140766, National Health and Medical Research Council, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Copenhagen = Københavns Universitet (KU), Università degli Studi di Bologna, University of Bari Aldo Moro (UNIBA), University of Newcastle [Australia] (UoN), University of Parma = Università degli studi di Parma [Parme, Italie], University of Debrecen, Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Henri Mondor, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Ondokuz Mayis University, Centre de recherche en neurosciences de Lyon (CRNL), Physiopathologie de la Plasticité Neuronale (Neurocentre Magendie - U1215 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Strasbourg (UNISTRA)-Hôpital de Hautepierre [Strasbourg]-Nouvel Hôpital Civil de Strasbourg, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Internationality, Subgroup analysis, Rate ratio, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Natalizumab, Multiple Sclerosis, Relapsing-Remitting, 030225 pediatrics, Internal medicine, Secondary Prevention, Medicine, Humans, Immunologic Factors, Pharmacology (medical), Longitudinal Studies, Registries, 10. No inequality, Expanded Disability Status Scale, business.industry, Proportional hazards model, Fingolimod Hydrochloride, Multiple sclerosis, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, Middle Aged, medicine.disease, Fingolimod, 3. Good health, multiple sclerosis, sex, age, natalizumab, fingolimod, big data, Psychiatry and Mental health, Cohort, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Immunosuppressive Agents, medicine.drug, Follow-Up Studies
Abstract: Introduction: Natalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined. Objective: The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS subgroups defined by the baseline demographic and clinical characteristics of interest. Methods: Patients with RRMS who were given natalizumab or fingolimod were identified in a merged cohort from three international registries. Efficacy outcomes were compared across subgroups based on patients’ sex, age, disease duration, Expanded Disability Status Scale (EDSS) score, and disease and magnetic resonance imaging (MRI) activity 12 months prior to treatment initiation. Study endpoints were number of relapses (analyzed withweighted negative binomial generalized linear model) and 6-month confirmed disability worsening and improvement events (weighted Cox proportional hazards model), recorded during study therapy. Each patient was weighted using inverse probability of treatment weighting based on propensity score. Results: A total of 5148 patients (natalizumab 1989; fingolimod 3159) were included, with a mean ± standard deviation age at baseline of 38 ± 10 years, and the majority (72%) were women. The median on-treatment follow-up was 25 (quartiles 15–41) months. Natalizumab was associated with fewer relapses than fingolimod (incidence rate ratio [IRR]; 95% confidence interval [CI]) in women (0.76; 0.65–0.88); in those aged ≤38 years (0.64; 0.54–0.76); in those withdisease duration ≤7 years (0.63; 0.53–0.76); in those with EDSS score 38 years (1.34; 1.04–1.73); those with disease duration >7 years (1.33; 1.01–1.74); those with EDSS score
Published: 2021
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45. Mitochondrial Fatty Acid β-Oxidation and Resveratrol Effect in Fibroblasts from Patients with Autism Spectrum Disorder

Author: Indrapal Singh, Jean Bastin, Patrick John McCarty, Rita Barone, Fatima Djouadi, Richard E. Frye, Mohammad A. Karim, Antonino Casabona, Amrit Ammanamanchi, Rose Shannon, Renata Rizzo, Leanna Delhey, Gestionnaire, Hal Sorbonne Université, University of Catania [Italy], Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Phoenix Children's Hospital, Arkansas Children's Research Institute, and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)
Subjects: 0301 basic medicine, medicine.medical_specialty, genetic structures, [SDV]Life Sciences [q-bio], Medicine (miscellaneous), autism spectrum disorder, Resveratrol, resveratrol, behavioral disciplines and activities, Article, Mitochondrial fatty acid, 03 medical and health sciences, Social Responsiveness Scale, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, mental disorders, energy metabolism, medicine, In patient, Fibroblast, Beta oxidation, fatty acid oxidation, business.industry, Mean age, medicine.disease, [SDV] Life Sciences [q-bio], 030104 developmental biology, medicine.anatomical_structure, Endocrinology, chemistry, acyl-carnitines, Autism spectrum disorder, Medicine, business, 030217 neurology & neurosurgery
Abstract: Patients with autism spectrum disorder (ASD) may have an increase in blood acyl-carnitine (AC) concentrations indicating a mitochondrial fatty acid β-oxidation (mtFAO) impairment. However, there are no data on systematic mtFAO analyses in ASD. We analyzed tritiated palmitate oxidation rates in fibroblasts from patients with ASD before and after resveratrol (RSV) treatment, according to methods used for the diagnosis of congenital defects in mtFAO. ASD participants (N = 10, 60%, male, mean age (SD) 7.4 (3.2) years) were divided in two age-equivalent groups based on the presence (N = 5) or absence (N = 5) of elevated blood AC levels. In addition, electron transport chain (ETC) activity in fibroblasts and muscle biopsies and clinical characteristics were compared between the ASD groups. Baseline fibroblast mtFAO was not significantly different in patients in comparison with control values. However, ASD patients with elevated AC exhibited significantly decreased mtFAO rates, muscle ETC complex II activity, and fibroblast ETC Complex II/III activity (p &lt, 0.05), compared with patients without an AC signature. RSV significantly increased the mtFAO activity in all study groups (p = 0.001). The highest mtFAO changes in response to RSV were observed in fibroblasts from patients with more severe symptoms on the Social Responsiveness Scale total (p = 0.001) and Awareness, Cognition, Communication and Motivation subscales (all p &lt, 0.01). These findings suggested recognition of an ASD patient subset characterized by an impaired mtFAO flux associated with abnormal blood AC. The study elucidated that RSV significantly increased fibroblast mtFAO irrespective of plasma AC status, and the highest changes to RSV effects on mtFAO were observed in the more severely affected patients.
Published: 2021
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46. Integrating science on Xanthomonadaceae for sustainable plant disease management in Europe

Author: Vittoria Catara, Joana Costa, Ralf Koebnik, Joël F. Pothier, Marie Agnès Jacques, Emilio Stefani, Jens Boch, University of Coimbra [Portugal] (UC), Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Martin-Luther-University Halle-Wittenberg, Department of Life Sciences, Institut de Recherche en Horticulture et Semences (IRHS), Université d'Angers (UA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Catania [Italy], Plant Health Institute of Montpellier (UMR PHIM), and Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)
Subjects: Xanthomonadaceae, 0106 biological sciences, 632: Pflanzenkrankheiten, Schädlinge, Soil Science, Plant Science, 01 natural sciences, 03 medical and health sciences, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Plant Diseases, 030304 developmental biology, 0303 health sciences, biology, business.industry, Disease Management, Plants, biology.organism_classification, Plant disease, Biotechnology, Europe, Editorial, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, 579: Mikrobiologie, business, Agronomy and Crop Science, 010606 plant biology & botany
Abstract: International audience
Published: 2021
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47. Cheese quality from cows given a tannin extract in 2 different grazing seasons

Author: M. Caccamo, Giuseppe Luciano, Antonio Natalello, Ruggero Menci, Bernardo Valenti, Mauro Coppa, Teresa Rapisarda, Isabelle Constant, Vincent Niderkorn, Alessandro Priolo, Antonio Difalco, University of Catania [Italy], Dipartimento di Scienze Agrarie ed Ambientali - Universita Udine (DISA), Università degli Studi di Udine - University of Udine [Italie], Consorzio Ricerca Filiera Lattiero Casearia (CORFILAC), Unité Mixte de Recherche sur les Herbivores - UMR 1213 (UMRH), and VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: [SDV]Life Sciences [q-bio], Pasture, tannin, 03 medical and health sciences, Rumen, Animal science, Cheese, Genetics, Tannin, Animals, Lactation, Dairy cattle, Dry matter, Cheesemaking, grazing season, 030304 developmental biology, 2. Zero hunger, chemistry.chemical_classification, 0303 health sciences, geography, geography.geographical_feature_category, Chemistry, Plant Extracts, dairy cow, 0402 animal and dairy science, cheese quality, 04 agricultural and veterinary sciences, 040201 dairy & animal science, Animal Feed, Diet, Milk, Food security, food quality and human health, Dietary Supplements, Hay, Animal Science and Zoology, Cattle, Female, Seasons, Tannins, Food Science, Polyunsaturated fatty acid
Abstract: International audience; The aim of the present study was to compare the effect of dietary tannins on cow cheese quality in 2 different grazing seasons in the Mediterranean. Two experiments were performed on 14 dairy cows reared in an extensive system. The first experiment took place in the wet season (WS), and the second experiment took place in the dry season (DS). In the WS and DS experiments, cows freely grazed green pasture or dry stubbles, respectively, and the diet was supplemented with pelleted concentrate and hay. In both experiments, the cows were divided into 2 balanced groups: a control group and a group (TAN) receiving 150 g of tannin extract/head per day. After 23 d of dietary treatment, individual milk was collected, processed into individual cheeses, and aged 25 d. Milk was analyzed for chemical composition, color parameters, and cheesemaking aptitude (laboratory cheese yield and milk coagulation properties). Cheese was analyzed for chemical composition, proteolysis, color parameters, rheological parameters, fatty acid profile, and odor-active volatile compounds. Data from the WS and DS experiments were statistically analyzed separately with an analysis of covariance model. In the WS experiment, dietary tannin supplementation had no effect on milk and cheese parameters except for a reduced concentration of 2-heptanone in cheese. In the DS experiment, TAN milk showed lower urea N, and TAN cheese had lower C18:1 trans-10 concentration and n-6:n-3 polyunsaturated fatty acid ratio compared with the control group. These differences are likely due to the effect of tannins on rumen N metabolism and fatty acid biohydrogenation. Dietary tannins may differently affect the quality of cheese from Mediterranean grazing cows according to the grazing season. Indeed, tannin bioactivity on rumen metabolism seems to be enhanced during the dry season, when diet is low in protein and rich in acid detergent fiber and lignin. The supplementation dose used in this study (1% of estimated dry matter intake) had no detrimental effects on cheese yield or cheesemaking parameters. Also, it is unlikely that sensorial characteristics would be affected by this kind of dietary tannin supplementation.
Published: 2021
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48. Binge-like alcohol exposure in adolescence: behavioural, neuroendocrine and molecular evidence of abnormal neuroplasticity … and return

Author: Cesare D’Amico, Martin Kuchar, Giuseppe Tringali, Vincenzo Micale, Salvatore Feo, Gianluca Lavanco, Valentina Castelli, Anna Brancato, Giuseppe Pizzolanti, Carla Cannizzaro, Università degli studi di Palermo - University of Palermo, INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, University of Catania [Italy], Università cattolica del Sacro Cuore [Roma] (Unicatt), University of Chemistry and Technology Prague (UCT Prague), ERAB: The European Foundation for Alcohol Research, Università di Catania, Brancato A., Castelli V., Lavanco G., Tringali G., Micale V., Kuchar M., D'amico C., Pizzolanti G., Feo S., Cannizzaro C., Admin, Oskar, Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), and Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt)
Subjects: Binge alcohol drinking, medicine.medical_specialty, Settore BIO/14 - FARMACOLOGIA, QH301-705.5, Medicine (miscellaneous), Nucleus accumbens, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Dopamine, Dopamine receptor D2, Internal medicine, Neuroplasticity, Medicine, Cannabidiol, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Biology (General), 030304 developmental biology, Dopamine transporter, 0303 health sciences, biology, Tyrosine hydroxylase, business.industry, Dopaminergic, Adolescence, Endocrinology, biology.protein, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Adolescence, Binge alcohol drinking, Cannabidiol, Nucleus accumbens, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: Binge alcohol consumption among adolescents affects the developing neural networks underpinning reward and stress processing in the nucleus accumbens (NAc). This study explores in rats the long-lasting effects of early intermittent exposure to intoxicating alcohol levels at adolescence, on: (1) the response to natural positive stimuli and inescapable stress, (2) stress-axis functionality, and (3) dopaminergic and glutamatergic neuroadaptation in the NAc. We also assess the potential effects of the non-intoxicating phytocannabinoid cannabidiol, to counteract (or reverse) the development of detrimental consequences of binge-like alcohol exposuredimensions. Our results show that adolescent binge-like alcohol exposure alters the sensitivity to positive stimuli, exerts social and novelty-triggered anxiety-like behaviour, and passive stress-coping during early and prolonged withdrawal. In addition, serum corticosterone and hypothalamic and NAc corticotropin-releasing hormone levels progressively increase during withdrawal. Besides, NAc tyrosine hydroxylase levels increase at late withdrawal, while the expression of dopamine transporter, D1 and D2 receptors xpression is dynamically altered during binge and withdrawal. Furthermore, the expression of markers of excitatory postsynaptic signaling —PSD95, Homer-1 and -2 and the activity-regulated spine-morphing proteins Arc, LIM Kinase 1 and FOXP1—increase at late withdrawal. Notably, subchronic cannabidiol, during withdrawal, attenuates social- and novelty-induced aversion and passive stress-coping and rectifies the hyper-responsive stress axis and NAc dopamine and glutamate-related neuroplasticity. Overall, the exposure to binge-like alcohol levels in adolescent rats makes the NAc, during withdrawal, a locus minoris resistentiae as a result of perturbations in neuroplasticity and in stress-axis homeostasis. Cannabidiol holds a promising potential for increasing behavioural, neuroendocrine and molecular resilience against binge-like alcohol level’s harmful effects.
Published: 2021
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49. Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A1 and A2A Receptors

Author: Renata Ciccarelli, Giuseppa Mudò, Patrizia Di Iorio, Roberta Garozzo, Fulvio Plescia, Daniele F. Condorelli, Monica Frinchi, Francisco Ciruela, Natale Belluardo, Valentina Di Liberto, Francesco Caciagli, Vincenzo Verdi, Maria Grillo, Università degli studi di Palermo - University of Palermo, Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Universitat de Barcelona (UB), University of Catania [Italy], University 'G. d'Annunzio' of Chieti-Pescara [Chieti and Pescara, Italy], Frinchi M., Verdi V., Plescia F., Ciruela F., Grillo M., Garozzo R., Condorelli D.F., Di Iorio P., Caciagli F., Ciccarelli R., Belluardo N., Di Liberto V., Mudo' G., Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), and Martinez Rico, Clara
Subjects: Light, Pharmacology, Anxiety, Settore BIO/09 - Fisiologia, Hippocampus, lcsh:Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Receptor, lcsh:QH301-705.5, Spectroscopy, caffeine, 0303 health sciences, Behavior, Animal, General Medicine, Darkness, 3. Good health, Computer Science Applications, adenosine, CCPA, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], A1R, Caffeine, medicine.drug, Receptor, Adenosine A2A, Guanosine, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, medicine, Animals, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Physical and Theoretical Chemistry, Binding site, 2A, Molecular Biology, 030304 developmental biology, Dose-Response Relationship, Drug, Receptor, Adenosine A1, behavior, Organic Chemistry, Cell Membrane, Antagonist, Adenosine, Adenosine receptor, Rats, guanosine, A2AR, lcsh:Biology (General), lcsh:QD1-999, chemistry, 030217 neurology & neurosurgery
Abstract: Acute or chronic administration of guanosine (GUO) induces anxiolytic-like effects, for which the adenosine (ADO) system involvement has been postulated yet without a direct experimental evidence. Thus, we aimed to investigate whether adenosine receptors (ARs) are involved in the GUO-mediated anxiolytic-like effect, evaluated by three anxiety-related paradigms in rats. First, we confirmed that acute treatment with GUO exerts an anxiolytic-like effect. Subsequently, we investigated the effects of pretreatment with ADO or A1R (CPA, CCPA) or A2AR (CGS21680) agonists 10 min prior to GUO on a GUO-induced anxiolytic-like effect. All the combined treatments blocked the GUO anxiolytic-like effect, whereas when administered alone, each compound was ineffective as compared to the control group. Interestingly, the pretreatment with nonselective antagonist caffeine or selective A1R (DPCPX) or A2AR (ZM241385) antagonists did not modify the GUO-induced anxiolytic-like effect. Finally, binding assay performed in hippocampal membranes showed that [3H]GUO binding became saturable at 100&ndash, 300 nM, suggesting the existence of a putative GUO binding site. In competition experiments, ADO showed a potency order similar to GUO in displacing [3H]GUO binding, whereas AR selective agonists, CPA and CGS21680, partially displaced [3H]GUO binding, but the sum of the two effects was able to displace [3H]GUO binding to the same extent of ADO alone. Overall, our results strengthen previous data supporting GUO-mediated anxiolytic-like effects, add new evidence that these effects are blocked by A1R and A2AR agonists and pave, although they do not elucidate the mechanism of GUO and ADO receptor interaction, for a better characterization of GUO binding sites in ARs.
Published: 2020
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50. Introduction

Author: Lange, Manfred, Llasat, Maria, Snoussi, Maria, Graves, Arnault, Le Tellier, Julien, Queralt, Arnau, Vagliasindi, Grazia, The Cyprus Institute, Nicosia, Cyprus, University of Barcelona - UB [Spain], Faculty of Sciences of Rabat, University Mohammed V of Rabat, Rabat, Morocco, Union for the Mediterranean, Barcelona, Spain, United Nations Environment Programme / Mediterranean Action Plan (UNEP/MAP), Advisory Council for the Sustainable Development of Catalonia of the Government of Catalonia (CADS), University of Catania [Italy], Cramer W, Guiot J, and Marini K
Subjects: health care facilities, manpower, and services, education, [SDE]Environmental Sciences, health care economics and organizations
Abstract: First Mediterranean Assessment Report; International audience
Published: 2020

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