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1. Benefits associated with the standing position during visual search tasks

Author

Cédrick T. Bonnet, Tarkeshwar Singh, Jose A. Barela, Université de Lille, CNRS, CHU Lille, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab], Pennsylvania State University [Penn State], Universidade de São Paulo = University of São Paulo [USP], Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Pennsylvania State University (Penn State), Penn State System, and Universidade de São Paulo = University of São Paulo (USP)

Subjects
[SCCO]Cognitive science, Postural sway, Sitting position · Standing position, Task performance, Selectivity of attention, Young adults, General Neuroscience
Abstract

International audience; The literature on postural control highlights that task performance should be worse in challenging dual tasks than in a single task because the brain has limited attentional resources. Instead, in the context of visual tasks, we assumed that i) performance in a visual search task should be better when standing than when sitting and ii) when standing, postural control should be better when searching than performing the control task. 32 and 16 young adults participated in studies 1 and 2, respectively. They performed three visual tasks (searching to locate targets, free-viewing and fixating a stationary cross) displayed in small images (visual angle: 22°) either when standing or when sitting. Task performance, eye, head, upper back, lower back and center of pressure displacements were recorded. In both studies, task performance in searching was as good (and clearly not worse) when standing as when sitting. Sway magnitude was smaller during the search task (vs. other tasks) when standing but not when sitting. Hence, only when standing, postural control was adapted to perform the challenging search task. When exploring images, and especially so in the search task, participants rotated their head instead of their eyes as if they used an eye-centered strategy. Remarkably in Study 2, head rotation was greater when sitting than when standing. Overall, we consider that variability in postural control was not detrimental but instead useful to facilitate visual task performance. When sitting, this variability may be lacking, thus requiring compensatory movements.

Published
2022

2. Empirical formulation for multiple groups of primary biological ice nucleating particles from field observations over Amazonia

Author

Vaughan T. J. Phillips, Cindy E. Morris, Paul J. DeMott, Susannah M. Burrows, Sachin Patade, Bettina Weber, Fábio Luiz Teixeira Gonçalves, Christopher Pöhlker, Pierre Amato, Jann Schrod, Heinz Bingemer, Carl Alwmark, Daniel A. Knopf, Paulo Artaxo, Department of Physical Geography and Ecosystem Science [Lund], Lund University [Lund], Institut de Chimie de Clermont-Ferrand (ICCF), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Institute for Atmospheric and Environmental Sciences [Frankfurt/Main] (IAU), Goethe-University Frankfurt am Main, Atmospheric Sciences and Global Change Division, Pacific Northwest National Laboratory (PNNL), Department of Atmospheric Science [Fort Collins], Colorado State University [Fort Collins] (CSU), Departamento de Ciencias Atmosfericas [São Paulo], Instituto de Astronomia, Geofísica e Ciências Atmosféricas [São Paulo] (IAG), Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP), Institute for Terrestrial and Planetary Atmospheres [Stony Brook] (ITPA), School of Marine and Atmospheric Sciences [Stony Brook] (SoMAS), Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY)-Stony Brook University [SUNY] (SBU), State University of New York (SUNY)-State University of New York (SUNY), Unité de Pathologie Végétale (PV), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Geology [Lund], Universidade de São Paulo = University of São Paulo (USP), Multiphase Chemistry Department [Mainz], Max Planck Institute for Chemistry (MPIC), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Karl-Franzens-Universität Graz, Swedish Research Council (‘Vetenskapsradet’), German Federal Ministry of Education and Research (BMBF contracts 01LB1001A, 01LK1602A and 01LK1602B), U.S. National Science Foundation Award #1660486, NASA award NNX17AJ12G, Deutsche Forschungsgemeinschaft (DFG) under the Research Unit FOR 1525 (INUIT), Max Planck Society, Brazilian Ministério da Ciência, Tecnologia e Inovação (MCTI/FINEP contract 01.11.01248.00), Amazon State University (UEA), FAPEAM, LBA/INPA, SDS/CEUC/RDS-Uatumã, U.S. Department of Energy, Office of Science (BER), Atmospheric System Research (DE-SC0018929, DE-SC0016370, DE-SC0020006), European Project: 603445,EC:FP7:ENV,FP7-ENV-2013-two-stage,BACCHUS(2013), Universidade de São Paulo (USP)-Universidade de São Paulo (USP), Universidade de São Paulo (USP), Karl-Franzens-Universität [Graz, Autriche], and University of Graz

Subjects
[PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], Atmospheric Science, Detritus, 010504 meteorology & atmospheric sciences, Atmospheric models, biology, Amazon rainforest, medicine.disease_cause, Atmospheric sciences, biology.organism_classification, 01 natural sciences, Soot, 010305 fluids & plasmas, Aerosol, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Algae, FLORESTAS TROPICAIS, Pollen, 0103 physical sciences, medicine, Ice nucleus, Environmental science, [MATH]Mathematics [math], 0105 earth and related environmental sciences, Amazonie
Abstract

To resolve the various types of biological ice nuclei (IN) with atmospheric models, an extension of the empirical parameterization (EP) (Phillips et al. 2008; 2013) is proposed to predict the active IN from multiple groups of primary biological aerosol particles (PBAPs). Our approach is to utilize coincident observations of PBAP sizes, concentrations, biological composition, and ice-nucleating ability. The parameterization organizes the PBAPs into five basic groups: fungal spores, bacteria, pollen, viral particles, plant/animal detritus, algae, and their respective fragments. This new biological component of the EP was constructed by fitting predicted concentrations of PBAP IN to those observed at the Amazon Tall Tower Observatory (ATTO) site located in the central Amazon. The fitting parameters for pollen and viral particles, plant/animal detritus, which are much less active as IN than fungal and bacterial groups, are constrained based on their ice nucleation activity from the literature. The parameterization has empirically derived dependencies on the surface area of each group (except algae), and the effects of variability in their mean sizes and number concentrations are represented via their influences on the surface area. The concentration of active algal IN is estimated from literature-based measurements.Predictions of this new biological component of the EP are consistent with previous laboratory and field observations not used in its construction. The EP scheme was implemented in a 0D parcel model. It confirms that biological IN account for most of the total IN activation at temperatures warmer than −20°C and at colder temperatures dust and soot become increasingly more important to ice nucleation.

Published
2021

3. Persistent postoperative ascites successfully identified and treated with laparoscopic indocyanine green fluorescence

Author

Rodrigo Fernandes, Jesus Paula Carvalho, Ulysses Ribeiro, Andre Lopes, Cristina Anton, Alexandre Silva e Silva, Eric Leblanc, INSERM, Université de Lille, Universidade de São Paulo = University of São Paulo [USP], Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192, Universidade de São Paulo = University of São Paulo (USP), Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 (PRISM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)

Subjects
Indocyanine Green, medicine.medical_specialty, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Urology, Pelvis, 03 medical and health sciences, Lymphocele, Postoperative Complications, 0302 clinical medicine, Chylous ascites, Ascites, medicine, Humans, Coloring Agents, Chylous Ascites, Aorta, Ovarian Neoplasms, 030219 obstetrics & reproductive medicine, business.industry, Optical Imaging, Obstetrics and Gynecology, Cytoreduction Surgical Procedures, Middle Aged, medicine.disease, Lymphatic system, Oncology, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Lymph Node Excision, Female, Lymphadenectomy, medicine.symptom, Ovarian cancer, business, Complication, Indocyanine green fluorescence
Abstract

International audience; Lymphatic ascites after a lymphadenectomy due to disruption of lymphatic vessels is a complication reported to happen in 2.7% of those procedures.1–3 There are several types of lymphatic leakage reported in the literature such as lymphorrhea, lymphocele, lymphatic ascites, chylous ascites, and lymphatic fistula. Medical treatment is the primary treatment of choice and has been reported to cure ascites in 66% to 77% of cases.1 Surgical treatment to identify the leakage site should not be considered as the first choice and is reserved if medical treatment fails to solve it.1 4 Indocyanine green (ICG) and fluorescence imaging (FI) have been vastly used for different purposes including sentinel lymph node identification for different types of cancer, retina evaluation, and organ perfusion before resection. In addition, ICG and FI have potential to solve contemporary problems in gynecologic oncology and may be used to evaluate perfusion of colorectal anastomosis or uterine perfusion after radical trachelectomy.5 6 In this video we present a case where ICG and FI were used to help identify the precise site of lymphatic leakage and successfully solve it. Different from previous authors who published ICG interdigital foot injection, we demonstrate an alternative application at the proximal part of the thigh.7A 59-year-old woman diagnosed with high-grade serous ovarian carcinoma FIGO stage IIIC, underwent upfront debulking surgery with total hysterectomy, bilateral adnexectomy, omentectomy, and partial lymphadenectomy in another hospital.The patient was referred to our institution and underwent six cycles of chemotherapy with carboplatin-paclitaxel, however she persisted with enlarged pelvic and para-aortic lymph nodes, suspicious for secondary involvement without any other sites of metastasis. We decided to perform systematic pelvic and para-aortic lymphadenectomy. A few days after the surgery the patient developed ascites confirmed by the clinical aspect and biochemical evaluation of the fluid.Conservative treatment consisting of parenteral nutrition, a low-fat diet with medium-chain triglycerides, and several percutaneous drainages were unsuccessful. Then we decided to perform laparoscopy, ICG, and FI to fix the leakage.During the procedure 1.2 liters of lymphatic ascites were drained. An injection of 1 mL of ICG in three sites of the proximal part of both thighs was performed and after 10 min the use of near infrared fluorescence successfully identified the active leakage site. Several metal clips were used to stop the leakage.After surgery the patient was discharged with no further complications. Long-term follow-up demonstrated no more ascites.The use of laparoscopy and ICG subcutaneous injection appears as a promising technique to identify active lymphatic leakage and treat it surgically. The injection of ICG to the thigh appears to be an alternative to interdigital foot injection.

Published
2020

4. The Forest Effects on the Isotopic Composition of Rainfall in the Northwestern Amazon Basin

Author

Renato Campello Cordeiro, Jhan Carlo Espinoza, Angela Ampuero, Valdir F. Novello, Nicola M. Stríkis, Francisco W. Cruz, Hubert B. Vonhof, James Apaéstegui, Victor C. Mayta, Mathias Vuille, Abdelfettah Sifeddine, V. Azevedo, Veridiana Teixeira de Souza Martins, Universidade Federal Fluminense [Rio de Janeiro] (UFF), Instituto Geofísico del Perú (IGP), Department of Atmospheric and Environmental Sciences [Albany] (DAES), University at Albany [SUNY], State University of New York (SUNY)-State University of New York (SUNY), Instituto de Geociências [São Paulo], Universidade de São Paulo = University of São Paulo (USP), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Max Planck Institute for Chemistry (MPIC), Max-Planck-Gesellschaft, Departamento de Ciencias Atmosfericas [São Paulo], Instituto de Astronomia, Geofísica e Ciências Atmosféricas [São Paulo] (IAG), Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP), Variabilité à long terme du climat de l'océan (VALCO), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), ANR-18-MPGA-0008,AMANECER,Connexion Amazone - Andes(2018), Universidade de São Paulo (USP), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Universidade de São Paulo (USP)-Universidade de São Paulo (USP), Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut de Recherche pour le Développement (IRD)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Institut de Recherche pour le Développement (IRD)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)

Subjects
Atmospheric Science, geography, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, Amazon rainforest, Speleothem, [PHYS.PHYS.PHYS-GEO-PH]Physics [physics]/Physics [physics]/Geophysics [physics.geo-ph], 15. Life on land, 010502 geochemistry & geophysics, 01 natural sciences, Isotopic composition, DEUTÉRIO, Geophysics, 13. Climate action, Space and Planetary Science, Earth and Planetary Sciences (miscellaneous), Environmental science, Precipitation, Physical geography, Holocene, 0105 earth and related environmental sciences, Amazon basin
Abstract

International audience; In the Amazon basin, intense precipitation recycling across the forest significantly modifies the isotopic composition of rainfall (δ18O, δD). In the tropical hydrologic cycle, such an effect can be identified through deuterium excess (dxs), yet it remains unclear what environmental factors control dxs, increasing the uncertainty of dxs‐based paleoclimate reconstructions. Here we present a 4‐year record of the isotopic composition of rainfall, monitored in the northwestern Amazon basin. We analyze the isotopic variations as a function of the air mass history, based on atmospheric back trajectory analyses, satellite observations of precipitation upstream, leaf area index, and simulated moisture recycling along the transport pathway. We show that the precipitation recycling in the forest exerts a significant control on the isotopic composition of precipitation in the northwestern Amazon basin, especially on dxs during the dry season (r = 0.71). Applying these observations to existing speleothem and pollen paleorecords, we conclude that winter precipitation increased after the mid‐Holocene, as the expansion of the forest allowed for more moisture recycling. Therefore, forest effects should be considered when interpreting paleorecords of past precipitation changes.

Published
2020

5. 5-Hydroxymethylfurfural and Furfural Base-Free Oxidation over AuPd Embedded Bimetallic Nanoparticles

Author

Cleber Wanderlei Liria, Camila P. Ferraz, Liane M. Rossi, M. Teresa Machini, Renato Froidevaux, Natalia J. S. Costa, Robert Wojcieszak, Franck Dumeignil, Erico Teixeira-Neto, Ângela A. Teixeira-Neto, Joëlle Thuriot-Roukos, Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, Universidade de São Paulo (USP), Institut Charles Viollette (ICV) - ULR 7394 (ICV), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)2014/10824-3 2017/03235-02014/15159-8, Laboratório Nacional de Nanotecnologia, CNPEM, Institute of Chemistry, University of São Paulo, University of São Paulo (USP), Institut Charles Viollette (ICV) - EA 7394 (ICV), Université d'Artois (UA)-Institut National de la Recherche Agronomique (INRA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille, Unité de Catalyse et de Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Ecole Centrale de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Universidade de São Paulo = University of São Paulo [USP], and Institut Charles Viollette (ICV) - EA 7394 [ICV]

Subjects
Nanoparticle, 02 engineering and technology, 010402 general chemistry, Furfural, lcsh:Chemical technology, 01 natural sciences, 7. Clean energy, Catalysis, Metal, lcsh:Chemistry, chemistry.chemical_compound, base-free, [CHIM]Chemical Sciences, lcsh:TP1-1185, Partial oxidation, Physical and Theoretical Chemistry, Bimetallic strip, ComputingMilieux_MISCELLANEOUS, bimetallic nanoparticles, biomass, Chemistry, green oxidation, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, 021001 nanoscience & nanotechnology, 0104 chemical sciences, 3. Good health, embedded catalysts, Chemical engineering, lcsh:QD1-999, visual_art, visual_art.visual_art_medium, Leaching (metallurgy), 0210 nano-technology, Selectivity, BIOMASSA
Abstract

The heterogeneous catalytic partial oxidation of alcohols and aldehydes in the liquid phase usually needs the addition of a homogeneous base, which in turn makes the products&rsquo, recovery cumbersome, and can further induce undesired side reactions. In the present work, we propose the use of novel catalysts based on metallic Au, Pd and bimetallic AuPd nanoparticles embedded in a titanosilicate matrix. The as-prepared catalysts showed good efficiency in the base-free partial oxidation of furfural and 5-hydroxymethylfurfural. Au4Pd1@SiTi catalyst showed high selectivity (78%) to monoacids (namely, 5-formyl-2-furancarboxylic acid and 5-hydroxymethyl-2-furancarboxylic acid) at 50% 5-hydroxymethylfurfural (HMF) conversion. The selectivity even reached 83% in the case of furfural oxidation to furoic acid (at 50% furfural conversion). The performances of the catalysts strongly depended on the Au&ndash, Pd ratio, with an optimal value of 4:1. The pH of the solution was always below 3.5 and no leaching of metals was observed, confirming the stabilization of the metal nanoparticles within the titanosilicate host matrix.

Published
2020

6. Multiscale Electrochemical Study of Welded Al Alloys Joined by Friction Stir Welding

Author

Nadine Pébère, Bernard Tribollet, Caio Palumbo de Abreu, Vincent Vivier, Hercílio Gomes de Melo, Isolda Costa, Laboratoire Interfaces et Systèmes Electrochimiques (LISE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Pesquisas Energéticas e Nucleares [São Paulo] (IPEN/CNEN-SP), Universidade de São Paulo = University of São Paulo (USP)-Comissão National de Energia Nuclear (CNEN), Departamento de Engenharia Metalurgica e de Materiais, Universidade de São Paulo = University of São Paulo (USP), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Comissão National de Energia Nuclear (CNEN)-Universidade de São Paulo (USP), Universidade de São Paulo (USP), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Université Pierre et Marie Curie, Paris 6 - UPMC (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Centro de Ciência e Tecnologia de Materiais - CCTM (IPEN) (BRAZIL), Universidade de São Paulo - USP (BRAZIL), Universidade de São Paulo (USP)-Comissão National de Energia Nuclear (CNEN), and Institut National Polytechnique de Toulouse - INPT (FRANCE)

Subjects
Electrochemical impedance, Materials science, Friction stir welding, 020209 energy, Intermetallic, chemistry.chemical_element, 02 engineering and technology, Welding, Electrolyte, Galvanic coupling, Science des matériaux, [SPI.MAT]Engineering Sciences [physics]/Materials, law.invention, Corrosion, Aluminium, law, Physique Nucléaire Théorique, 0202 electrical engineering, electronic engineering, information engineering, Materials Chemistry, Electrochemistry, Galvanic cell, Friction stir Welding, Physique Nucléaire Expérimentale, Renewable Energy, Sustainability and the Environment, Metallurgy, Aluminium alloys, Galvanic couplings, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Aluminum alloys, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Dielectric spectroscopy, chemistry, [CHIM.OTHE]Chemical Sciences/Other, 0210 nano-technology
Abstract

International audience; Friction stir welding (FSW) is an efficient way to join high strength aluminum alloys. However, FSW generates different microstructural areas in contact that may give rise to galvanic couplings, affecting the corrosion resistance of the assembly. In the present work, a multiscale electrochemical study of the 7475-T651 and 2024-T3 aluminum alloys butt-joined by FSW was carried out. Much lower impedances were associated with the FSW affected zones compared to the two aluminum base metals tested individually. Corrosion of the welded system resulted in the establishment of galvanic coupling, shown by local electrochemical impedance spectroscopy (LEIS) measurements, at which the AA7475 behaves anodically with respect to the AA2024. A Zn deposit was observed on the intermetallic particles of the AA2024 after 24 h of immersion in the electrolyte resulting from the galvanic coupling, which seems to reduce the galvanic coupling effects. Such a behavior in combination with LEIS results allowed a description of the galvanic coupling development between two different aluminum alloys (AA2024-T3 and AA7475-T761) butt-welded by FSW as a function of time from the early stage of immersion.

Published
2017

7. Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin

Author

Silvia Beatriz Boscardin, Tomoko Ishino, Marcio Massao Yamamoto, Olivier Silvie, Rogerio Amino, Sylvie Dartevelle, François Traincard, Masao Yuda, Raquel Hoffmann Panatieri, Joana Tavares, Eduardo Aliprandini, Sabine Thiberge, Infection et Immunité paludéennes - Malaria Infection and Immunity, Institut Pasteur [Paris] (IP), Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto = University of Porto, Instituto de Biologia Molecular e Celular - institute for molecular and cell biology [Porto, Portugal] (IBMC), Department of Parasitology [São Paulo] (IBS), Institute of Biomedical Sciences (ICB/USP), Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP), Centre de Production et Infection des Anophèles (plateforme) - Center for the Production and Infection of Anopheles (platform) (CEPIA), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Ehime University [Matsuyama, Japon], Mie University Graduate School / Faculty of Medicine [Japan], Mie University, Ingénierie des Anticorps (plate-forme) - Antibody Engineering (Platform), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), This work was supported by funds from Institut Pasteur, Paris, the French National Research Agency (grant no. ANR-14-CE16-Im3alaria), the French Government’s ‘Investissement d’Avenir’ program, Laboratoire d’Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (grant no. ANR-10-LABX-62-IBEID) and ‘ParaFrap’ (grant no. ANR-11-LABX-0024), the São Paulo Research Foundation (FAPESP, grant no. 2014/50631-0), the National Council for Scientific and Technological Development (CNPq), the BNP Paribas CIB, the Portuguese Science and Technology Foundation (FCT, grant no. IF/00881/2012/CP0158) and the European Social Fund (Human Potential Operational Programme)., We thank the team of the Centre of Production and Infection of Anopheles, Institut Pasteur, in particular M. Szatanik, C. Thouvenot, S. Golba, J. Pham and A. Lorthiois for providing mosquitoes and P. falciparum SPZs, the team of the Platform of Dynamic Imaging, Institut Pasteur, in particular Dr S. Shorte and M.-A. Nicola for the access to the confocal microscopes and IVIS system, Dr K. Kim from the Albert Einstein College of Medicine for providing the P. yoelii YM GFP-luciferase, Dr V. Nussenzweig from New York University for providing the P. berghei and falciparumnized P. berghei parasites, Dr M. Soares from the Instituto Gulbenkian for providing the JHT−/− mice, Dr P.-M. Lledo and Dr P. Bruhns from the Institut Pasteur for providing, respectively, the C3−/− and the FcRγ−/− mice, the team of the Clinical Investigation and Access to BioResources, in particular M.-N. Ungeheuer for providing the erythrocytes for the P. falciparum culture, Dr P. Baldacci and Dr P. Formaglio for their critical reading of the manuscript., ANR-14-CE16-0030,IM3alaria,Imagerie et amélioration de la protection immunitaire contre le parasite responsable du paludisme.(2014), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-11-LABX-0024,ParaFrap,Alliance française contre les maladies parasitaires(2011), Amino, Rogerio, Appel à projets générique - Imagerie et amélioration de la protection immunitaire contre le parasite responsable du paludisme. - - IM3alaria2014 - ANR-14-CE16-0030 - Appel à projets générique - VALID, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Laboratoires d'excellence - Alliance française contre les maladies parasitaires - - ParaFrap2011 - ANR-11-LABX-0024 - LABX - VALID, Institut Pasteur [Paris], Universidade do Porto, Universidade de São Paulo (USP)-Universidade de São Paulo (USP), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Ehime University [Matsuyama], and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, MESH: Antibodies, Protozoan/pharmacology, Plasmodium berghei, [SDV]Life Sciences [q-bio], Fc receptor, Protozoan Proteins, MESH: Antibodies, Monoclonal/pharmacology, Antibodies, Protozoan, Applied Microbiology and Biotechnology, MESH: Cell Movement/drug effects, Mice, MESH: Protozoan Proteins/immunology, Cell Movement, MESH: Animals, MESH: Plasmodium falciparum/immunology, Skin, MESH: Pore Forming Cytotoxic Proteins/metabolism, MESH: Sporozoites/cytology, biology, Antibodies, Monoclonal, 3. Good health, Circumsporozoite protein, MESH: Sporozoites/immunology, [SDV] Life Sciences [q-bio], [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Sporozoites, MESH: Skin/parasitology, MESH: Plasmodium berghei/immunology, [SDV.IMM.IA] Life Sciences [q-bio]/Immunology/Adaptive immunology, MESH: Plasmodium yoelii/cytology, MESH: Malaria/immunology, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, Antibody, Plasmodium yoelii, Microbiology (medical), Pore Forming Cytotoxic Proteins, [SDV.IMM] Life Sciences [q-bio]/Immunology, medicine.drug_class, Immunology, Plasmodium falciparum, MESH: Plasmodium yoelii/immunology, Monoclonal antibody, complex mixtures, Microbiology, 03 medical and health sciences, parasitic diseases, Genetics, medicine, Animals, MESH: Mice, fungi, Cell Biology, biology.organism_classification, Malaria, 030104 developmental biology, Culicidae, Humoral immunity, biology.protein, MESH: Culicidae, MESH: Female
Abstract

The circumsporozoite protein (CSP) is the major surface protein of malaria sporozoites (SPZs), the motile and invasive parasite stage inoculated in the host skin by infected mosquitoes. Antibodies against the central CSP repeats of different plasmodial species are known to block SPZ infectivity1–5, but the precise mechanism by which these effectors operate is not completely understood. Here, using a rodent Plasmodium yoelii malaria model, we show that sterile protection mediated by anti-P. yoelii CSP humoral immunity depends on the parasite inoculation into the host skin, where antibodies inhibit motility and kill P. yoelii SPZs via a characteristic ‘dotty death’ phenotype. Passive transfer of an anti-repeat monoclonal antibody (mAb) recapitulates the skin inoculation-dependent protection, in a complement- and Fc receptor γ-independent manner. This purified mAb also decreases motility and, notably, induces the dotty death of P. yoelii SPZs in vitro. Cytotoxicity is species-transcendent since cognate anti-CSP repeat mAbs also kill Plasmodium berghei and Plasmodium falciparum SPZs. mAb cytotoxicity requires the actomyosin motor-dependent translocation and stripping of the protective CSP surface coat, rendering the parasite membrane susceptible to the SPZ pore-forming-like protein secreted to wound and traverse the host cell membrane6. The loss of SPZ fitness caused by anti-P. yoelii CSP repeat antibodies is thus a dynamic process initiated in the host skin where SPZs either stop moving7, or migrate and traverse cells to progress through the host tissues7–9 at the eventual expense of their own life. In a rodent malaria model, antibodies against the CSP protein that coats sporozoites lead to Plasmodium yoelii killing in the skin in a process that involves stripping off the CSP coat, rendering parasites susceptible to pore-forming-like proteins.

Published
2018

8. Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

Author

Thiago M. Cunha, Lucas Esteves Cardozo, Florêncio Figueiredo, Konstantina Lyroni, Emilio Hirsch, F. N. Gava, João Santana da Silva, Edecio Cunha-Neto, Renata Sesti-Costa, Christophe Chevillard, Carla D. Lopes, Maria R. C. da Silva, Marcela Davoli-Ferreira, Christos Tsatsanis, José C. Alves-Filho, Fernando Q. Cunha, Fabrício C. Dias, Helder I. Nakaya, Monique Andrade Baron, Amanda Farage Frade, Tiago Medina, Grace K. Silva, University of Minho [Braga], Universidade do Porto = University of Porto, School of Medicine of Ribeirão Preto (FMRP), Universidade de São Paulo = University of São Paulo (USP), Heart Institute (InCor), Universidade de São Paulo = University of São Paulo (USP)-Faculdade de Medicina FMUSP, Yerkes National Primate Research Center [Lawrenceville, GA], Emory University [Atlanta, GA], Theories and Approaches of Genomic Complexity (TAGC), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Genetics, Biology and Biochemistry, Université de Turin, Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa (INESC-ID), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST)-Instituto de Engenharia de Sistemas e Computadores (INESC), ANR-11-LABX-0024,ParaFrap,Alliance française contre les maladies parasitaires(2011), University of Porto, School of Medicine of Ribeirão Preto ( FMRP ), University of São Paulo ( USP ), Heart Institute ( InCor ), Universidade de São Paulo ( USP ) -Faculdade de Medicina FMUSP, Yerkes National Primate Research Centre, Theories and Approaches of Genomic Complexity ( TAGC ), Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Technologies avancées pour le génôme et la clinique ( TAGC ), Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa ( INESC-ID ), Instituto Superior Técnico, Universidade Técnica de Lisboa ( IST ) -Instituto de Engenharia de Sistemas e Computadores ( INESC ), Universidade do Porto, University of São Paulo (USP), Universidade de São Paulo (USP)-Faculdade de Medicina FMUSP, and Faculdade de Medicina FMUSP-Universidade de São Paulo (USP)

Subjects
Chagas Cardiomyopathy, Male, 0301 basic medicine, Chagas disease, Heart disease, Biopsy, [SDV]Life Sciences [q-bio], Cardiomyopathy, General Physics and Astronomy, 030204 cardiovascular system & hematology, Inbred C57BL, Mice, 0302 clinical medicine, [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology, Protozoan infections, Class Ib Phosphatidylinositol 3-Kinase, Myeloid Cells, lcsh:Science, ComputingMilieux_MISCELLANEOUS, Phosphoinositide-3 Kinase Inhibitors, Mice, Knockout, Multidisciplinary, Heart, Middle Aged, Canonical, Up-Regulation, 3. Good health, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Female, Signal transduction, Signal Transduction, Adult, [ SDV.MP.PAR ] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Myocarditis, Knockout, Trypanosoma cruzi, Science, [ SDV.BBM.BM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, Downregulation and upregulation, Quinoxalines, Protozoan infection, parasitic diseases, medicine, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology, [ SDV ] Life Sciences [q-bio], Animal, Myocardium, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Molecular mechanisms, General Chemistry, Disease Models, Animal, Mice, Inbred C57BL, Thiazolidinediones, medicine.disease, biology.organism_classification, 030104 developmental biology, Disease Models, Immunology, MIOCARDIOPATIAS, lcsh:Q
Abstract

Chagas disease is caused by infection with the protozoan Trypanosoma cruzi (T. cruzi) and is an important cause of severe inflammatory heart disease. However, the mechanisms driving Chagas disease cardiomyopathy have not been completely elucidated. Here, we show that the canonical PI3Kγ pathway is upregulated in both human chagasic hearts and hearts of acutely infected mice. PI3Kγ-deficient mice and mutant mice carrying catalytically inactive PI3Kγ are more susceptible to T. cruzi infection. The canonical PI3Kγ signaling in myeloid cells is essential to restrict T. cruzi heart parasitism and ultimately to avoid myocarditis, heart damage, and death of mice. Furthermore, high PIK3CG expression correlates with low parasitism in human Chagas’ hearts. In conclusion, these results indicate an essential role of the canonical PI3Kγ signaling pathway in the control of T. cruzi infection, providing further insight into the molecular mechanisms involved in the pathophysiology of chagasic heart disease., Trypanosoma cruzi infection causes Chagas disease, but mechanisms underlying pathogenesis are unclear. Here, Silva et al. show that canonical PI3Kγ signaling in myeloid cells restricts T. cruzi infection in mice and that high PIK3CG expression correlates with low parasite levels in human Chagas’ hearts.

Published
2018

9. Genetic variants in selenoprotein genes modulate biomarkers of selenium status in 1 response to Brazil nut supplementation (the SU.BRA.NUT study) 2

Author

Donadio, Janaina L. S., Rogero, Marcelo M., Guerra-Shinohara, Elvira M., Barbosa Jr, Fernando, Desmarchelier, Charles, Borel, Patrick, Sneddon, Alan, Hesketh, John, Cozzolino, Silvia M. F., Department of Food and Experimental Nutrition [São Paulo, Brazil], University of São Paulo, Department of Nutrition [São Paulo, Brazil], University of São Paulo (USP), Department of Clinical and Toxicological Analysis [São Paulo, Brazil], Department of Clinical, Toxicological and Bromatological Analysis [Ribeirão Preto, Brazil], University of São Paulo (USP)-Faculty of Pharmaceutical Sciences of Ribeirão Preto, Centre recherche en CardioVasculaire et Nutrition (C2VN), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Rowett Institute of Nutrition & Health [Aberdeen, UK] (Metabolic Health Theme), University of Aberdeen, Institute for Cell and Molecular Biosciences, Newcastle University [Newcastle], Faculty of Pharmaceutical Sciences of Ribeirão Preto-University of São Paulo (USP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), FAPESP 2011/17720-0 2015/10146-8, Universidade de São Paulo = University of São Paulo (USP), Universidade de São Paulo = University of São Paulo (USP)-Faculty of Pharmaceutical Sciences of Ribeirão Preto, and Borel, Patrick

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Selenium, Glutathione peroxidase, Polymorphisms, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Nutrigenetics, SNPs
Abstract

International audience; BACKGROUND:The beneficial effects of selenium (Se) to human health are exerted by selenoproteins, which can be quantified in blood and used as biomarkers of Se status. Different responses of Se biomarkers after supplementation with selenomethionine and sodium selenite have been observed and some of them could be due to genetic polymorphisms, mainly single nucleotide polymorphisms (SNPs). Brazil nuts are known to be the richest natural source of Se.OBJECTIVE:Investigate how genetic variations in selenoprotein genes modulate biomarkers of Se status in response to Brazil nut supplementation.METHODS:The SU.BRA.NUT study was a four month interventional trial which involved healthy volunteers of both genders, selected in University of Sao Paulo. The supplementation was done with one Brazil nut a day for 8 weeks, followed by 8 weeks of washout. Blood samples were collected at 5 time points: baseline, 4 and 8 weeks of supplementation and 4 and 8 weeks of washout for analysis of five biomarkers of Se status - erythrocyte GPx1 (Glutathione Peroxidase 1) activity, plasma GPx3 activity, plasma Se, erythrocyte Se, and plasma selenoprotein P. The gene expression of GPX1, SELENOP, SELENOF and SELENOS was done before and after 8 weeks of supplementation. The volunteers were genotyped for SNPs in GPX1 (rs1050450, rs3811699 and rs1800699), GPX4 (rs713041), SELENOP (rs3877899 and rs7579), SELENOF (rs5845) and SELENOS (rs34713741).RESULTS:A total of 130 volunteers finished the protocol. The concentrations of four biomarkers of Se status increased significantly after 4 and 8 weeks of supplementation, being modulated by gender. In addition, erythrocyte GPx1 activity was associated with rs1050450, rs713041 and rs5845. Plasma Se was associated with rs7579 and selenoprotein P with plasma Se at baseline. Nut supplementation significantly increased GPX1 mRNA expression only in subjects with CC genotype at rs1050450. SELENOP mRNA expression was significantly lower in subjects with GG genotype at rs7579 before and after supplementation.CONCLUSION:Genetic variations in GPX1 and SELENOP genes are associated with different responses of molecular and biochemical biomarkers of Se status after Brazil nut supplementation in healthy Brazilians. The SU.BRA.NUT study was registred at www.clinicaltrials.gov as NCT 03111355.

Published
2018

10. Towards an automatic lidar cirrus cloud retrieval for climate studies

Author

Eliane G. Larroza, Riad Bourayou, Christophe Hoareau, Walter M. Nakaema, Philippe Keckhut, Eduardo Landulfo, Center for Lasers and Applications [São Paulo] (CLA), Instituto de Pesquisas Energéticas e Nucleares [São Paulo] (IPEN/CNEN-SP), Universidade de São Paulo = University of São Paulo (USP)-Comissão National de Energia Nuclear (CNEN)-Universidade de São Paulo = University of São Paulo (USP)-Comissão National de Energia Nuclear (CNEN), Laboratoire de Météorologie Dynamique (UMR 8539) (LMD), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-École des Ponts ParisTech (ENPC)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut Pierre-Simon-Laplace (IPSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP)-Comissão National de Energia Nuclear (CNEN), STRATO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Comissão National de Energia Nuclear (CNEN)-Universidade de São Paulo (USP)-Comissão National de Energia Nuclear (CNEN)-Universidade de São Paulo (USP), Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-École des Ponts ParisTech (ENPC)-École polytechnique (X)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Comissão National de Energia Nuclear (CNEN)-Universidade de São Paulo (USP)

Subjects
Atmospheric Science, Meteorology, 010504 meteorology & atmospheric sciences, [SDE.MCG]Environmental Sciences/Global Changes, Cloud computing, 01 natural sciences, 010309 optics, 0103 physical sciences, lcsh:TA170-171, Air mass, Remote sensing, 0105 earth and related environmental sciences, [PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], Ice crystals, Microphysics, business.industry, Orientation (computer vision), lcsh:TA715-787, lcsh:Earthwork. Foundations, lcsh:Environmental engineering, Lidar, 13. Climate action, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, Trajectory, Environmental science, Cirrus, business
Abstract

This paper presents a methodology to calculate lidar ratios for distinct cirrus clouds that has been developed and implemented for a site located in the Southern Hemisphere. The cirrus cloud lidar data processing aims to consider a large cloud variability and cirrus cloud monitoring through a robust retrieval process. Among cirrus features estimates for complex scenes that lidar systems can provide, we highlight cloud geometrical information and extinction-to-backscatter ratio (known as lidar ratio or LR). In general, direct information on cirrus cloud microphysics is difficult to derive because LR depends on the presence of ice crystals and their properties such as shape, size, composition and orientation of particles. An iterative process to derive a stable LR value has been proposed. One of the keys is to restrict the analysis to conditions allowing accurate multilayer events. This method uses nonparametric statistical approaches to identify stationary periods according to cloud features and variability. Measurements performed in the region of the metropolitan city of São Paulo (MSP) have been used to implement and test the methodology developed for cirrus cloud characterization. Good results are represented by examining specific cases with multilayer cirrus cloud occurrence. In addition to the geometrical parameters obtained, cirrus LR values were calculated for a single day ranging from 19 ± 01 sr to 74 ± 13 sr for 2 observed layers. This large difference in LR can indicate a mixture of ice crystal particles with different sizes and shapes in both layers of the cirrus clouds. Trajectory analyses indicate that both of these cloud layers can be associated with different air mass and should be considered as 2 distinct clouds in climatology.

Published
2018

11. Dietary Patterns in European and Brazilian Adolescents: Comparisons and Associations with Socioeconomic Factors

Author

Frédéric Gottrand, Cinzia Le Donne, Betzabeth Slater, David Jiménez-Pavón, Yannis Manios, Kurt Widhalm, Luis A. Moreno, Alba M Santaliestra-Pasías, Ascensión Marcos, Jara Valtueña, Inge Huybrechts, Manuel J. Castillo, Stefaan De Henauw, Camila Aparecida Borges, Theodora Mouratidou, Dénes Molnár, Inserm, Université de Lille, CHU Lille, Lille Inflammation Research International Center (LIRIC) - U995, Universidade de São Paulo = University of São Paulo [USP], University of Zaragoza - Universidad de Zaragoza [Zaragoza], Centre International de Recherche contre le Cancer - International Agency for Research on Cancer [CIRC - IARC], Medizinische Universität Wien = Medical University of Vienna, Lille Inflammation Research International Center - U 995 [LIRIC], Harokopio University of Athens, Universidad de Cádiz [UCA], Instituto de Física Fundamental [Madrid] [IFF], Spanish National Research Council [CSIC], University of Pecs, Universiteit Gent = Ghent University [UGENT], Ministerio de Ciencia e Innovación (España), Ministerio de Economía y Competitividad (España), Abbott Fund, Ministerio de Educación y Ciencia (España), European Commission, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Universidade de São Paulo = University of São Paulo (USP), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Universidad de Cádiz (UCA), Instituto de Física Fundamental [Madrid] (IFF), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Spanish National Research Council (CSIC), Universidad de Granada = University of Granada (UGR), and Universiteit Gent = Ghent University (UGENT)

Subjects
Male, 0301 basic medicine, Secondary education, Adolescent, Low education, ANÁLISE FATORIAL, [SDV]Life Sciences [q-bio], dietary patterns, Mothers, University level, Developing country, factor analysis, lcsh:TX341-641, adolescents, socioeconomic status, Adolescents, Article, Eating, Fathers, 03 medical and health sciences, Residence Characteristics, Humans, Occupations, Dietary patterns, Socioeconomic status, Principal Component Analysis, 030109 nutrition & dietetics, Nutrition and Dietetics, 4. Education, 1. No poverty, Feeding Behavior, Europe, Geography, Socioeconomic Factors, Adolescent Behavior, Linear Models, Educational Status, Female, Factor analysis, lcsh:Nutrition. Foods and food supply, Brazil, Food Science, Demography
Abstract

Associations between dietary patterns (DP) and socioeconomic factors have been little explored in adolescents. The aim of this study was to identify DP in European and Brazilian adolescents and to investigate their associations with a range of socioeconomic indicators. Adolescents from the HELENA-study and the Household Budget Survey were analyzed. Factor analysis was used to obtain DP. Linear regression was used to examine the association between DP and SES. In Europeans, the Western DP was associated with low education of the mother, high socioeconomic status (boys), older age (boys), and living in cities of the Northern Europe; in Brazilians, the Western DP was associated with high secondary education of the mother, high socioeconomic status and living in Southern areas of the country. The Traditional European DP, in both genders, was associated with high secondary education of the mother and inversely associated with a high socioeconomic status; the Traditional Brazilian DP, was associated with university level education of the mother and older age (boys). The association between DP and socioeconomic factors is relevant for the understanding of food-related practices and highlight the importance of performing a complete assessment of the socioeconomic influence in adolescent’s DP from developed and developing countries., Sources of Funding: the HELENA study received funding from the European Union’s Sixth RTD Framework Programme (Contracts FOOD-CT-2007-036196-2 and FOODCT-2005-007034, respectively). Additional support was received from the Spanish Ministry of Education (AGL2007-29784-E/ALI), Axis-Shield Diagnostics Ltd. (Oslo, Norway), Abbot Científica S.A. (Spain). The HBS was funded by the Ministry of Health of Brazil (agreement number 4652/2005; grant number 25000.202044/2005-16). C.A.B. received a fellowship from the Brazilian Federal Agency (Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior-CAPES) and A.M.S.P received financial support by Fundación Cuenca Villoro (Spain) both for the improvement of higher education. D.J.P was supported by a grant from the Spanish Ministry of Science and Innovation—MINECO (RYC-2014-16938).

Published
2018
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12. Long-Range Transport of Water Channelized through the Southern Subtropical Jet

Author

Hélène Vérèmes, Walter M. Nakaema, Davide Dionisi, Eliane G. Larroza, Philippe Keckhut, Eduardo Landulfo, Jean-Luc Baray, François Ravetta, Sergey Khaykin, Center for Lasers and Applications [São Paulo] (CLA), Instituto de Pesquisas Energéticas e Nucleares [São Paulo] (IPEN/CNEN-SP), Universidade de São Paulo = University of São Paulo (USP)-Comissão National de Energia Nuclear (CNEN)-Universidade de São Paulo = University of São Paulo (USP)-Comissão National de Energia Nuclear (CNEN), STRATO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Météorologie Physique (LaMP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP), Laboratoire de l'Atmosphère et des Cyclones (LACy), Institut national des sciences de l'Univers (INSU - CNRS)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS)-Météo-France, CNR Institute of Atmospheric Sciences and Climate (ISAC), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), TROPO - LATMOS, Universidade de São Paulo (USP)-Comissão National de Energia Nuclear (CNEN)-Universidade de São Paulo (USP)-Comissão National de Energia Nuclear (CNEN), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Météo France-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), and Consiglio Nazionale delle Ricerche (CNR)

Subjects
Convection, Atmospheric Science, 010504 meteorology & atmospheric sciences, Equator, cirrus, lcsh:QC851-999, 010501 environmental sciences, Environmental Science (miscellaneous), Atmospheric sciences, complex mixtures, 01 natural sciences, Troposphere, Altitude, water vapor, Air mass, 0105 earth and related environmental sciences, [PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, subtropical jet, Jet stream, Lidar, 13. Climate action, lcsh:Meteorology. Climatology, Cirrus, sense organs, Geology
Abstract

In this study, an air mass (containing a cirrus cloud) was detected by light detection and ranging (lidar) above S&atilde, o Paulo (Brazil) in June 2007 and tracked around the globe, thanks to Lagrangian calculations as well as ground-based and satellite observations. Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation (CALIPSO) data were also used to provide locations of occurrence of cirrus around the globe and extract their respective macro physical parameters (altitude and temperature). An analysis of the air mass history based on Lagrangian trajectories reveals that water coming from the Equator is channelized through the southern subtropical jet for weeks. In this case, the back-trajectories showed that the cirrus cloud detected at S&atilde, o Paulo was a mixture of air masses from two different locations: (1) the active convective area located around the Equator, with transport into the upper troposphere that promotes cirrus cloud formation, and (2) the South Pacific Ocean, with transport that follows the subtropical jet stream (STJ). Air masses coming from equatorial convective regions are trapped by the jet, which contributes to maintaining the lifetime of the cirrus cloud for a few days. The cloud disappears near the African continent, due to a southern excursion and warmer temperatures, then reappears and is detected again by the lidar system in S&atilde, o Paulo after 12 days. The observed cloud is located at a similar altitude, revealing that sedimentation is small or compensated by radiative uplift.

Published
2018

13. A perspective on the need and current status of efficient sex separation methods for mosquito genetic control

Author

Michelle Cristine Pedrosa, Herve C Bossin, Philippos Aris Papathanos, Kostas Bourtzis, Abdoulaye Diabaté, Amadou Guindo, Frédéric Tripet, Jair F. Virginio, Patric Stephane Epopa, Margareth Lara Capurro, Franck Adama Yao, Mamadou B. Coulibaly, Lakamy Sylla, The Hebrew University of Jerusalem (HUJ), Insect Pest Control Laboratory (IPC laboratory), Food and Agriculture Organization of the United Nations [Rome, Italie] (FAO)-International Atomic Energy Agency [Vienna] (IAEA), Keele University [Keele], Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Biofabrica Moscamed Brazil, Department of Parasitology [São Paulo] (IBS), Institute of Biomedical Sciences (ICB/USP), Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP), Malaria Research and Training Center [Bamako, Mali], Université de Bamako, Centre Muraz [Bobo-Dioulasso, Burkina Faso], FundingPublication costs for this study was provided by the International AtomicEnergy Agency as part of the Coordinated Research Project'Exploringgenetic, molecular, mechanical and behavioural methods of sex separationin mosquitoes', Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), and Universidade de São Paulo (USP)-Universidade de São Paulo (USP)

Subjects
Male, 0301 basic medicine, Sex Determination Analysis, Mosquito Control, Review, Sterile insect technique, 0302 clinical medicine, Mosquito, Aedes, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, biology, 3. Good health, Infectious Diseases, Sex separation, Scale (social sciences), Female, Research program, ANIMAIS PARASITOS, 030231 tropical medicine, Control (management), Gene drive, Genetic control, Genetic sexing strains, Sexing, Mosquito Vectors, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Anopheles, medicine, Animals, Humans, lcsh:RC109-216, Environmental planning, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, business.industry, QH, Gene Drive Technology, biology.organism_classification, medicine.disease, Malaria, 030104 developmental biology, Agriculture, Infertility, Parasitology, business
Abstract

International audience; Major efforts are currently underway to develop novel, complementary methods to combat mosquito-borne diseases. Mosquito genetic control strategies (GCSs) have become an increasingly important area of research on account of their species-specificity, track record in targeting agricultural insect pests, and their environmentally non-polluting nature. A number of programs targeting Aedes and Anopheles mosquitoes, vectors of human arboviruses and malaria respectively, are currently being developed or deployed in many parts of the world. Operationally implementing these technologies on a large scale however, beyond proof-of-concept pilot programs, is hampered by the absence of adequate sex separation methods. Sex separation eliminates females in the laboratory from male mosquitoes prior to release. Despite the need for sex separation for the control of mosquitoes, there have been limited efforts in recent years in developing systems that are fit-for-purpose. In this special issue of Parasites and Vectors we report on the progress of the global Coordinated Research Program on Exploring genetic, molecular, mechanical and behavioural methods for sex separation in mosquitoes that is led by the Insect Pest Control Subprogramme of the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture with the specific aim of building efficient sex separation systems for mosquito species. In an effort to overcome current barriers we briefly highlight what we believe are the three main reasons why progress has been so slow in developing appropriate sex separation systems: the availability of methods that are not scalable, the difficulty of building the ideal genetic systems and, finally, the lack of research efforts in this area.

Published
2018

14. Influence of probe size for local electrochemical impedance measurements

Author

Vincent Vivier, P. H. Suegama, Isolda Costa, Caio Palumbo de Abreu, Michel Keddam, Hercílio Gomes de Melo, Camila Molena de Assis, Instituto de Pesquisas Energéticas e Nucleares [São Paulo] (IPEN/CNEN-SP), Universidade de São Paulo = University of São Paulo (USP)-Comissão National de Energia Nuclear (CNEN), Departamento de Engenharia Metalurgica e de Materiais, Universidade de São Paulo = University of São Paulo (USP), Faculdade de Ciencias Exatas e Tecnologia-UFGD, Rodovia Dourados-Itahum, Laboratoire Interfaces et Systèmes Electrochimiques (LISE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo (USP)-Comissão National de Energia Nuclear (CNEN), and Universidade de São Paulo (USP)

Subjects
Materials science, 020209 energy, General Chemical Engineering, Analytical chemistry, 02 engineering and technology, Parasitic capacitance, 0202 electrical engineering, electronic engineering, information engineering, Electrochemistry, [CHIM]Chemical Sciences, Spectroscopy, Electrical impedance, Local electrochemical impedance, business.industry, Stray capacitance, Probe size, Time constant, 021001 nanoscience & nanotechnology, Dielectric spectroscopy, Local current density, Microelectrode, Frequency domain, Electrode, Optoelectronics, 0210 nano-technology, business, [CHIM.OTHE]Chemical Sciences/Other, Microelectrodes
Abstract

International audience; Local electrochemical impedance spectroscopy (LEIS) is a promising technique for the characterization ofheterogeneous surface reactivity. Significant development of LEIS relies on the improvement of thespatial resolution for reaching the micrometer scale. This work presents the influence of the probe size,especially in the high frequency domain where an inductive-like response ascribed to the stray dielectriccapacitance between the two electrodes of the probe used for performing the local current measurementcan be observed. A detailed analysis of the whole set-up (electrode geometry and measuring device)allows an analytical expression of the impedance for the whole system to be obtained. Based on theanalysis of this expression and on experimental results, two different strategies have been proposed tocancel the HF time constant: a post treatment of the results via a preliminary electrical characterizationof the local probe or the minimization of the electrolyte resistance by measuring the local potential in theclose vicinity of the substrate. Both approaches were shown to be efficient.

Published
2017

15. Multichannel EMG-based estimation of fiber conduction velocity during isometric contraction of patients with different stages of diabetic neuropathy

Author

Marco K. Butugan, Isabel C. N. Sacco, Neli Regina Siqueira Ortega, Ricky Watari, Maria Cecília S. Martins, Vincent Vigneron, Cristina D. Sartor, Physical Therapy, Speech and Occupational Therapy Dept., Polytechnic School [São Paulo], University of São Paulo (USP)-University of São Paulo (USP), Center of Fuzzy Systems in Health, Informatique, Biologie Intégrative et Systèmes Complexes (IBISC), Université d'Évry-Val-d'Essonne (UEVE), and Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP)

Subjects
Male, Diabetic neuropathy, Diabetic polyneuropathies, Biophysics, Neuroscience (miscellaneous), Electromyography, Isometric exercise, Isometric contraction, Biceps, Nerve conduction velocity, Quadriceps Muscle, Diabetic Neuropathies, Fuzzy Logic, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Diabetes mellitus, Humans, Medicine, Muscle, Skeletal, Electrodes, Aged, Muscle fiber, Neural Conduction, medicine.diagnostic_test, business.industry, Peripheral Nervous System Diseases, Anatomy, Middle Aged, medicine.disease, Lower Extremity, Thigh, Case-Control Studies, Neural conduction, Disease Progression, Female, Neurology (clinical), Analysis of variance, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; This study compares muscle fiber conduction velocities estimated using surface electromyography during isometric maximal voluntary contraction in different stages of diabetic neuropathy. Eighty-five adults were studied: 16 non-diabetic individuals and 69 diabetic patients classified into four neuropathy stages, defined by a fuzzy expert system: absent (n = 26), mild (n = 21), moderate (n = 11) and severe (n = 11). Average muscle fiber conduction velocities of gastrocnemius medialis, tibialis anterior, vastus lateralis and biceps femoris were assessed using linear array electrodes, and were compared by ANOVA. Conduction velocities were significantly decreased in the moderate neuropathy group for the vastus lateralis compared to other groups (from 18% to 21% decrease), and were also decreased in all diabetic groups for the tibialis anterior (from 15% to 20% from control group). Not only the distal anatomical localization of the muscle affects the conduction velocity, but also the proportion of muscle fiber type, where the tibialis anterior with greater type I fiber proportion is affected earlier while the vastus lateralis with greater type II fiber proportion is affected in later stages of the disease. Generally, the muscles of the lower limb have different responsiveness to the effects of diabetes mellitus and show a reduction in the conduction velocity as neuropathy progresses.

Published
2014

16. An eosimiid primate of South Asian affinities in the Paleogene of Western Amazonia and the origin of New World monkeys

Author

Marivaux, Laurent, Negri, Francisco, Antoine, Pierre-Olivier, Stutz, Narla, Condamine, Fabien, Kerber, Leonardo, Pujos, François, Santos, Roberto, Alvim, André, Hsiou, Annie, Bissaro Júnior, Marcos, Adami-Rodrigues, Karen, Ribeiro, Ana, Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Universidade Federal do Acre, Cruzeiro Do Sul (UFAC), Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Universidade Federal de Santa Maria = Federal University of Santa Maria [Santa Maria, RS, Brazil] (UFSM), Museu Paraense Emílio Goeldi [Belém, Brésil] (MPEG), Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales [Mendoza] (CONICET-IANIGLA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad Nacional de Cuyo [Mendoza] (UNCUYO), Universidade de Brasilia [Brasília] (UnB), Universidade de São Paulo = University of São Paulo (USP), Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Museu de Ciências Naturais/Seção de Paleontologia, Brazilian Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, 306951/2017-7, 312941/2018-8, 140773/2019-3, 310023/2021-1, and 310948/2021-5, CNPq/MCTI/CONFAP-FAPS PROTAX 22/2020 441626/2020-3, and FAPERGS 21/2551-0000781-8)., Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, COFECUB program Te 924/18, 88881.143095/2017-01)., São Paulo Research Foundation (FAPESP, process 2011/14080-0 and 2019/14153-0)., LabEx CEBA (ANR-10-LABX-25-01, and strategic project EMERGENCE).

Subjects
Teeth, Basal Anthropoidea, Paleobiogeography, [SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/Paleontology, Brazilian Amazonia, Phylogeny, Platyrrhini
Abstract

International audience; Recent fossil discoveries in Western Amazonia revealed that two distinct anthropoid primate clades of African origin colonized South America near the Eocene/Oligocene transition (ca. 34 Ma). Here we describe a diminutive fossil primate from Brazilian Amazonia and suggest that, surprisingly, a third clade of anthropoids was involved in the Paleogene colonization of South America by primates. This new taxon, Ashaninkacebus simpsoni gen. et sp. nov., has strong dental affinities with Asian-African stem anthropoids: the Eosimiiformes. Morphology-based phylogenetic analyses of early Old World anthropoids and extinct and extant New World monkeys (platyrrhines) support relationships of both Ashaninkacebus and Amamria (late middle Eocene, North Africa) to the South Asian Eosimiidae. Afro-Arabia, then a mega-island, played the role of a biogeographic stopover between South Asia and South America for anthropoid primates and hystricognathous rodents. The earliest primates from South America bear little adaptive resemblance to later Oligocene-early Miocene platyrrhine monkeys, and the scarcity of available paleontological data precludes elucidating firmly their affinities with or within Platyrrhini. Nonetheless, these new data shed light on some of their life-history traits, revealing a particularly small body size and a diet consisting primarily of insects and possibly fruit, which would have increased their chances of survival on a natural floating island during this extraordinary over-water trip to South America from Africa. Divergence-time estimates between Old and New World taxa indicate that the transatlantic dispersal(s) could source in the intense flooding events associated with the late middle Eocene climatic optimum (ca. 40.5 Ma) in Western Africa.

Published
2023

17. A interação entre emissões de vegetação e humana e seu efeito na qualidade do ar em São Paulo em um contexto de mudanças climáticas

Author

Ferreira de Brito, Joel, Oliveira, Amauri, Staudt, Michael, Souza, Silvia, Jaffrezo, Jean-Luc, Ynoue, Rita Yuri, Borbon, Agnès, Fornaro, Adalgiza, Centre for Energy and Environment (CERI EE - IMT Nord Europe), Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Nord Europe), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Universidade de São Paulo = University of São Paulo (USP), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Institute of Astronomy, Geophysics and Atmospheric Sciences (IAG), Laboratoire de Météorologie Physique (LaMP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), ANR-20-CE01-0019,BIOMASPplus,Emissions biogéniques, évolution et impact dans la mégapole de São Paulo(2020), and ANR-11-LABX-0005,Cappa,Physiques et Chimie de l'Environnement Atmosphérique(2011)

Subjects
[SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere
Abstract

International audience

Published
2023

18. Phases supergènes de cuirasses ferrugineuses : micro-échantillonnage non destructif et minéralogie avant analyse géochronologique (U–Th) ∕ He

Author

Karina Patricia Prazeres Marques, Thierry Allard, Cécile Gautheron, Benoît Baptiste, Rosella Pinna-Jamme, Guillaume Morin, Ludovic Delbes, Pablo Vidal-Torrado, Escola Superior de Agricultura 'Luiz de Queiroz' (ESALQ), Universidade de São Paulo = University of São Paulo (USP), Minéralogie Environnementale [IMPMC] (IMPMC_MINENV), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Géosciences Paris Saclay (GEOPS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), The São Paulo Research Foundation – FAPESP (grant nos. 2017/20788-2, 2017/22292-4, 2019/10708-7), and ANR-17-CE01-0012,RECA,RElation entre le Changement climatique et formation des lAtérites(2017)

Subjects
Duricrust, [SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry, Geochronology, [CHIM.CRIS]Chemical Sciences/Cristallography, Iron oxides and oxihydroxides, Mineralogy, X-ray diffraction, [SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
Abstract

Interpreting the ages of supergene mineralogical phases in laterite is complex because they consist of polycrystalline mixtures of different phases at the microscopic scale that could be crystalized at different epochs. Among the geochronometers, the (U-Th)/He method on hematite and goethite is more often used, but ages can be difficult to interpret due to phases mixing. To resolve this issue, this study proposes a methodology for performing detailed mineralogical analysis of hematite and goethite single grains prior to their dating using the (U-Th)/He method. Strictly non-destructive mineralogy of single grains is not achievable by classical tools, such as conventional powder XRD (X-ray diffraction; requiring at least some milligrams of powder) or SEM (scanning electron microscopy; that can contaminate the grain by coating or fixing). Therefore, we performed X-ray diffraction patterns of single grains using high-flux X-ray beams from both a rotating anode (XRD_rotat) laboratory diffractometer and a synchrotron beamline (XRD_synch) and compared the results in order to design a method based on XRD_rotat only. For this purpose, two samples from the pisolitic facies of a Brazilian ferruginous duricrust (Alto Paranaíba region, Minas Gerais State, Brazil) were chosen because they presented a usual heterogeneity. Rietveld refinements of the XRD patterns obtained from both XRD_rotat and XRD_synch yielded similar results for the weight percentage ratio of the main phases and mean coherent domain sizes and less similar results for Al substitution rates, thus validating the XRD_rotat approach. No beam damage was observed when increasing X-ray exposure time, neither on XRD patterns nor on (U-Th)/He ages. Hence, sub-millimeter, undisturbed grains can be used to analyze the mineralogy of ferruginous duricrusts by XRD_rotat with a short exposure, and the same grains can subsequently be dated by (U-Th)/He geochronology analysis. The (U-Th)/He dating of pisolitic core and cortex grains also provided meaningful ages: they revealed two evolution phases of the ferruginous duricrust, which occurred at or before the Oligocene for the pisolitic core and middle Miocene for the pisolitic cortex, agreeing with the previous model for the development of pisolites. The mineralogy of single grains selected for dating is helpful for discussing the crystallization ages, and the high-flux XRD approach may be applied to other supergene mineral parageneses used for absolute dating.

Published
2023

19. Evolution of serum cytokine profile after hematopoietic stem cell transplantation in systemic sclerosis patients

Author

Lucas C. M. Arruda, C Deligny, E I Grigore, J.M. van Laar, Fred P.H.T.M. Romijn, J. van Pelt, Z Marjanovic, Laurence Michel, Dominique Farge, Franck Verrecchia, N Levarht, Francette Jean-Louis, J Baraut, Raphaël Porcher, Immunologie, dermatologie, oncologie, Oncodermatologie, immunologie et cellules souches cutanées (IDO (U976 / UMR_S 976)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7), Alloimmunité-Autoimmunité-Transplantation (A2T), Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Biostatistiques [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Klinische Chemie en Laboratoriumgeneeskunde - KCL [Leiden, Pays-Bas], Leiden University Medical Center (LUMC), Center for Cell-based Therapy [Ribeirão Preto, Brazil] (Regional Blood Center), University of São Paulo (USP)-Ribeirão Preto Medical School [Brazil], Department of Biochemistry and Immunology [Ribeirão Preto, Brazil], University of São Paulo (USP)- Ribeirã o Preto Medical School [Ribeirão Preto, Brazil], Department of rheumatology [Leiden, Pays-Bas], Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institute of Cellular Medicine [Newcastle], Newcastle University [Newcastle], This work was supported by Groupe Francophone de Recherche sur la Sclérodermie (GFRS), Association des Sclérodermiques de France (ASF), INSERM, Agence Nationale pour la Recherche, the Délégation Régionale à la Recherche Clinique (DRRC) from the Assistance Publique-Hôpitaux de Paris (AP-HP), the French Ministry of Health (PHRC 1997 AOM 6597–030) and the Etablissement Français des Greffes., Universidade de São Paulo = University of São Paulo (USP)-Ribeirão Preto Medical School [Brazil], Universidade de São Paulo = University of São Paulo (USP)- Ribeirã o Preto Medical School [Ribeirão Preto, Brazil], Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), and maurice, sandrine

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Pathology, T-Lymphocytes, medicine.medical_treatment, Inflammation, [SDV.CAN]Life Sciences [q-bio]/Cancer, Hematopoietic stem cell transplantation, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Fibrosis, Internal medicine, medicine, Journal Article, Humans, Progenitor cell, ComputingMilieux_MISCELLANEOUS, 030203 arthritis & rheumatology, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Transplantation, Scleroderma, Systemic, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Hematology, business.industry, Hematopoietic Stem Cell Transplantation, Middle Aged, medicine.disease, 3. Good health, Treatment Outcome, surgical procedures, operative, 030104 developmental biology, Graft-versus-host disease, Case-Control Studies, Immunology, Cytokines, Female, medicine.symptom, Stem cell, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Evolution of serum cytokine profile after hematopoietic stem cell transplantation in systemic sclerosis patients

Published
2016

20. Genome sequence of Aedes aegypti, a major arbovirus vector

Author

Sergio Verjovski-Almeida, James E. Galagan, Ryan C. Kennedy, Zhiyong Xi, Jason R. Miller, Eric Eisenstadt, Kyanne R. Reidenbach, Robert V. Bruggner, Yu-Hui Rogers, Hadi Quesneville, Doreen Werner, Owen White, Alexander S. Raikhel, Mario Stanke, J. Spencer Johnston, Diane D. Lovin, Evgenia V. Kriventseva, Ian T. Paulsen, Kathryn S. Campbell, Norman H. Lee, Ewan Birney, Karyn Megy, Hean Koo, David Kulp, Shelby L. Bidwell, Jingsong Zhu, Philip Montgomery, Paolo Amedeo, Yongmei Zhao, Chinnappa D. Kodira, Javier Costas, Michael C. Schatz, Steven P. Sinkins, Claire M. Fraser-Liggett, Martin Shumway, Kurt LaButti, Akio Mori, Brendan J. Loftus, Manfred Grabherr, Eric O. Stinson, Frank H. Collins, Zhijian Jake Tu, Monique R. Coy, Matt Crawford, Janice P. Vanzee, William M. Gelbart, Joshua Orvis, Peter Arensburger, Chunhong Mao, Evgeny M. Zdobnov, Saul A. Kravitz, Suely Lopes Gomes, David DeCaprio, David G. Hogenkamp, Daniel Lawson, Dennis L. Knudson, David W. Severson, George Dimopoulos, Marcelo B. Soares, Sinéad B. O'Leary, Peter W. Atkinson, David M. Jaffe, Becky deBruyn, Martin Hammond, Ana L. T. O. Nascimento, Jim Biedler, Stefan Wyder, Jose M. C. Tubio, Bruce W. Birren, Catherine A. Hill, Chad Nusbaum, Eduardo Lee, Song Li, Susan E. Brown, Jennifer R. Wortman, James R. Hogan, Hamza El-Dorry, Qi Zhao, Linda Hannick, Carlos Frederico Martins Menck, Vishvanath Nene, Jonathan Crabtree, Steven L. Salzberg, Michael H. Holmes, Maria de Fatima Bonaldo, Quinghu Ren, Mihaela Pertea, Charles Roth, Evan Mauceli, Karin Eiglmeier, Horacio Naveira, Brian J. Haas, Qiandong Zeng, Neil F. Lobo, Jennifer R. Schneider, The Institute for Genomic Research, The Institute for Genomic Research, Rockville, European Bioinformatics Institute [Hinxton] ( EMBL-EBI ), European Molecular Biology Laboratory [Hinxton], Broad Institute of MIT and Harvard ( BROAD INSTITUTE ), Broad Institute of MIT and Harvard, Virginia Polytechnic Institute and State University [Blacksburg], University College Dublin [Dublin] ( UCD ), Bloomberg School of Public Health, Johns Hopkins University ( JHU ) -Bloomberg School of Public Health, University of Geneva Medical School, Swiss Institute of Bioinformatics-University of Geneva Medical School, University of Notre Dame ( UND ), Harvard University [Cambridge], College of Agricultural Sciences Colorado State University, Colorado State University [Fort Collins] ( CSU ) -College of Agricultural Sciences, Northwestern University [Evanston], University of California [Riverside] ( UCR ), Department of Atmospheric, Oceanic and Planetary Physics [Oxford] ( AOPP ), University of Oxford [Oxford], Purdue University [West Lafayette], Centro Nacional de Genotipado Fundación Pública Galega de Medicina Xenómica Hospital Clínico Universitario de Santiago, Centro Nacional de Genotipado-Fundación Pública Galega de Medicina Xenómica-Hospital Clínico Universitario de Santiago, Institut Pasteur [Paris], Universidade de Sao Paulo Instituto de Quimica, Universidade de São Paulo ( USP ) -Instituto de Quimica, Texas A&M University [College Station], Joint Technology Center, University of Massachusetts [Amherst] ( UMass Amherst ), Universidade de Sao Paulo, Institute of Biomedical Sciences, Universidade de São Paulo ( USP ) -Institute of Biomedical Sciences, Instituto Butantan [São Paulo], Universidade da Coruña, University of Maryland [College Park], Institut Jacques Monod ( IJM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), University of California [Santa Cruz] ( UCSC ), Complexo Hospitalario Universitario de Santiago, Universität Göttingen, Georg-August-Universität Göttingen, George Washington University Medical Center, George Washington University ( GW ), The Institute for Genomic Research (TIGR), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], University College Dublin [Dublin] (UCD), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne (UNIL)-Université de Lausanne (UNIL)-University of Geneva Medical School, University of Notre Dame [Indiana] (UND), Colorado State University [Fort Collins] (CSU)-College of Agricultural Sciences, University of California [Riverside] (UCR), University of California, Department of Atmospheric, Oceanic and Planetary Physics [Oxford] (AOPP), Universidade de São Paulo (USP)-Instituto de Quimica, University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS), Universidade de São Paulo (USP)-Institute of Biomedical Sciences (ICB/USP), Universidade de São Paulo (USP), University of Maryland System, Institut Jacques Monod (IJM (UMR_7592)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), University of California [Santa Cruz] (UCSC), Georg-August-University [Göttingen], The George Washington University (GW), George Washington University (GW), Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL)-University of Geneva Medical School, Harvard University, University of California [Riverside] (UC Riverside), University of California (UC), University of Oxford, Institut Pasteur [Paris] (IP), Universidade de São Paulo = University of São Paulo (USP)-Instituto de Quimica, Universidade de São Paulo = University of São Paulo (USP)-Institute of Biomedical Sciences (ICB/USP), Universidade de São Paulo = University of São Paulo (USP), University of California [Santa Cruz] (UC Santa Cruz), Georg-August-University = Georg-August-Universität Göttingen, Zdobnov, Evgeny, and Wyder, Stefan

Subjects
0106 biological sciences, Male, Transcription, Genetic, Genome, Insect, transposons, receptors, Genes, Insect, Aedes/ genetics/metabolism, MESH: Genes, Insect, Yellow Fever/prevention & control/transmission, MESH: Base Sequence, 01 natural sciences, Dengue/prevention & control/transmission, MESH: Protein Structure, Tertiary, MESH: Arboviruses, MESH : Insect Vectors, MESH: Insect Proteins, MESH : Anopheles gambiae, MESH: Animals, MESH : Arboviruses, insects, MESH: Yellow Fever, superfamily, ddc:616, 0303 health sciences, Anopheles, MESH : Genes, Insect, 3. Good health, yellow-fever mosquito, anopheles-gambiae, drosophila-melanogaster, expression, evolution, organization, Drosophila melanogaster, MESH: DNA Transposable Elements, [ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Multigene Family, Public Health, MESH : Protein Structure, Tertiary, MESH: Sex Characteristics, Molecular Sequence Data, MESH : Multigene Family, MESH: Sex Determination (Genetics), MESH : Sex Determination (Genetics), Arbovirus, Article, 03 medical and health sciences, Species Specificity, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], MESH: Anopheles gambiae, Yellow Fever, MESH: Species Specificity, Humans, MESH: Humans, MESH: Molecular Sequence Data, fungi, MESH : Humans, MESH : Sex Characteristics, Membrane Transport Proteins, Sex Determination Processes, medicine.disease, Insect Vectors, Protein Structure, Tertiary, Sex Determination (Genetics), MESH: Multigene Family, MESH: Female, MESH : Sequence Analysis, DNA, MESH: Sequence Analysis, DNA, Drosophila melanogaster/genetics, MESH : Molecular Sequence Data, Odorant binding, Insect Proteins/genetics, Anopheles gambiae, MESH: Dengue, Genome, MESH: Membrane Transport Proteins, Dengue, MESH : Membrane Transport Proteins, Aedes, Insect Vectors/ genetics/metabolism, MESH : Drosophila melanogaster, MESH : Female, Membrane Transport Proteins/genetics, Genetics, MESH : Insect Proteins, Sex Characteristics, Multidisciplinary, MESH: Synteny, MESH: Aedes, MESH : Genome, Insect, MESH : DNA Transposable Elements, Insect Proteins, Female, Orthologous Gene, MESH : Male, MESH : Dengue, Aedes aegypti, MESH: Insect Vectors, Biology, 010603 evolutionary biology, Synteny, MESH: Drosophila melanogaster, Protein Structure, Tertiary/genetics, MESH : Yellow Fever, parasitic diseases, medicine, MESH : Species Specificity, Animals, 030304 developmental biology, MESH : Aedes, Base Sequence, MESH: Genome, Insect, MESH: Transcription, Genetic, MESH : Synteny, MESH : Transcription, Genetic, Sequence Analysis, DNA, biology.organism_classification, MESH: Male, DNA Transposable Elements, MESH : Base Sequence, MESH : Animals, Arboviruses, Anopheles gambiae/genetics/metabolism
Abstract

We present a draft sequence of the genome of Aedes aegypti , the primary vector for yellow fever and dengue fever, which at ∼1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae . Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of ∼4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster . Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of ∼2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.

Published
2016

21. A new species of Chryxus Champion, with taxonomic notes on other species of the genus (Hemiptera, Heteroptera, Reduviidae, Chryxinae)

Author

Hélcio R. Gil-Santana, John M. Leavengood Jr., Jean-Michel Bérenger, David dos Santos Martins, Jader Oliveira, Instituto Oswaldo Cruz / Oswaldo Cruz Institute [Rio de Janeiro] (IOC), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Universidade de São Paulo = University of São Paulo (USP), and Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP)

Subjects
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Insecta, Arthropoda, Reduvoidea, Panama, female and male genitalia, Chryxus, Assassin bugs, Biota, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Chryxinae, Hemiptera, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Animalia, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Animal Science and Zoology, Guyana, Reduviidae, Ecology, Evolution, Behavior and Systematics
Abstract

Chryxus garcetebarrettisp. nov. from Paraguay is described, taxonomical notes on C. bahianus Gil-Santana, Costa & Marques, 2007 and C. tomentosus Champion, 1899 are provided; the latter species is recorded from French Guiana for the first time; a redescription of the genus Chryxus Champion, 1899 and an updated key for the genera and species of Chryxinae are presented.

Published
2022

22. Specific force map for smart machining applications with rotating tools

Author

Sughosh Deshpande, Maria Clara Coimbra Gonçalves, Anna Carla Araujo, Pierre Lagarrigue, Yann Landon, Institut Clément Ader (ICA), Institut Supérieur de l'Aéronautique et de l'Espace (ISAE-SUPAERO)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-IMT École nationale supérieure des Mines d'Albi-Carmaux (IMT Mines Albi), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and Universidade de São Paulo = University of São Paulo (USP)

Subjects
specific coefficients, monitoring, axial drilling, cutting forces, Material identification, Mechanical Engineering, helical milling, [SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph], Industrial and Manufacturing Engineering
Abstract

International audience; Industry 4.0 is the need of the hour in current global market scenario and all the processes are moving towards automation and smart manufacturing. In machining, smart techniques implementation depends on developing a database for decision-making, which is the case for stack drilling in aerospace industry. In this application, choosing one optimal condition for several materials is a challenge due to their different machinability. Hence, material identification techniques are suitable approaches for adapting the cutting parameters in real time, which improves tool life, hole quality and productivity. In that regard, the goal of the present paper is to create a specific force data map for axial drilling and circular milling processes based on its experimental force and power measurements. To do that, experiments were separately carried out on Titanium and Aluminium workpieces in a range of cutting speed and feed conditions. The results show that specific cutting and feed forces for each material can be identified on distinct regions of the map, without thresholds overlapping. Given that, these maps can be used as a signature to distinguish two metallic materials in real time machining. In this case, the specific data points at the interface layers may offer advantage to accurately identify tool position unlike monitoring gradient of feed forces while drilling stacked materials. Therefore, smart machining techniques seeking cutting parameters optimization can be implemented for a particular material.

Published
2022

23. $$\textbf{E}\times \textbf{B}$$ Drift Particle Transport in Tokamaks

Author

L.A. Osorio-Quiroga, G.C. Grime, M. Roberto, R.L. Viana, Y. Elskens, I.L. Caldas, Instituto de Fisica da Universidade de São Paulo (IFUSP), Universidade de São Paulo = University of São Paulo (USP), Instituto Tecnológico de Aeronáutica [São José dos Campos] (ITA), instituto de fisica, universidade federal do Parana, Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), CNPq, CAPES, FAPESP, COFECUB, and CAPES/COFECUB Complex dynamics of plasmas Ph908/18 / 4027QA

Subjects
[PHYS]Physics [physics], General Physics and Astronomy
Abstract

10 pages, 9 figures, 1 table. Published in Brazilian Journal of Physics; International audience; In tokamaks, modification of the plasma profiles can reduce plasma transport, improving particle confinement. However, this improvement is still not completely understood. In this work, we consider a drift wave test particle model to investigate the influence of the electric and magnetic field profiles on plasma transport. Test particle orbits subjected to ExB drift are numerically integrated and their transport coefficient is obtained. We conclude that sheared profiles reduce particle transport, even for high amplitude perturbations. In particular, nonmonotonic electric and magnetic fields produce shearless transport barriers, which are particularly resistant to perturbations and reduce even more the transport coefficient.

Published
2023

24. Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

Author

Qing Li, Jieyi Chen, Pierre Faux, Miguel Eduardo Delgado, Betty Bonfante, Macarena Fuentes-Guajardo, Javier Mendoza-Revilla, J. Camilo Chacón-Duque, Malena Hurtado, Valeria Villegas, Vanessa Granja, Claudia Jaramillo, William Arias, Rodrigo Barquera, Paola Everardo-Martínez, Mirsha Sánchez-Quinto, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Caio C. Silva de Cerqueira, Tábita Hünemeier, Virginia Ramallo, Sijie Wu, Siyuan Du, Andrea Giardina, Soumya Subhra Paria, Mahfuzur Rahman Khokan, Rolando Gonzalez-José, Lavinia Schüler-Faccini, Maria-Cátira Bortolini, Victor Acuña-Alonzo, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Winston Rojas, Francisco Rothhammer, Nicolas Navarro, Sijia Wang, Kaustubh Adhikari, Andrés Ruiz-Linares, Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University [Shanghai]-Collaborative Innovation Center for Genetics and Development, CAS Key Laboratory of Computational Biology, Chinese Academy of Sciences [Beijing] (CAS)-University of Chinese Academy of Sciences [Beijing] (UCAS)-Shanghai Institute of Nutrition and Health, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), División Antropología [La Plata] (DA), Facultad de Ciencias Naturales y Museo [La Plata] (FCNyM), Universidad Nacional de la Plata [Argentine] (UNLP)-Universidad Nacional de la Plata [Argentine] (UNLP), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Departamento de Tecnología Médica, Universidad de Tarapaca, Laboratorios de Investigación y Desarrollo (LID), Universidad Peruana Cayetano Heredia (UPCH), Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Division of Vertebrates and Anthropology, The Natural History Museum [London] (NHM), Laboratorio de Genética Molecular, Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Molecular Genetics Laboratory, National School of Anthropology and History [Mexico City, Mexico] (NSAH), Department of Archaeogenetics [Jena] (DAG), Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Forensic Science, Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Unidad de Genomica de Poblaciones Aplicada a la Salud, Scientific Police of São Paulo State [Ourinhos, Brazil], Departamento de Genética e Biologia Evolutiva, Universidade de São Paulo = University of São Paulo (USP), Departamento de Genética, Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), Instituto Patagónico de Ciencias Sociales y Humanas, School of Mathematics and Statistics [Milton Keynes], Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), Facultad de Medicina & Instituto de Alta Investigacion, Universidad de Tarapaca-Universidade de Chile, Biogéosciences [UMR 6282] (BGS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL), Centre for Biodiversity and Environment Research, Department of Genetics, Evolution and Environment, University College of London [London] (UCL), the National Natural Science Foundation of China (#31771393), the Scientific and Technology Committee of Shanghai Municipality (18490750300), Ministry of Science and Technology of China (2020YFE0201600), Shanghai Municipal Science and Technology Major Project (2017SHZDZX01) and the 111 Project (B13016), the Leverhulme Trust (F/07 134/DF), BBSRC (BB/I021213/1), Universidad de Antioquia (CODI sostenibilidad de grupos 2013- 2014 and MASO 2013-2014), Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (Apoio a Núcleos de Excelência Program), Fundação de Aperfeiçoamento de Pessoal de Nível Superior and the National Institute of Dental and Craniofacial Research (R01-DE027023, U01-DE020078, R01-DE016148, X01-HG007821), Santander Research & Scholarship Award. B.B. is supported by a doctoral scholarship from Ecole Doctorale 251 Aix-Marseille Université., and ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011)

Subjects
MESH: Neanderthals, MESH: Cell Differentiation, MESH: Humans, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, MESH: Nose, Medicine (miscellaneous), Sitios de Carácter Cuantitativo, Quantitative trait, Genome-wide association studies, General Biochemistry, Genetics and Molecular Biology, Estudio de Asociación del Genoma Completo, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, MESH: Genome-Wide Association Study, MESH: Animals, General Agricultural and Biological Sciences, MESH: Mice
Abstract

e report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value

Published
2023

25. Aspergillus fumigatus Can Display Persistence to the Fungicidal Drug Voriconazole

Author

Jennifer Scott, Clara Valero, Álvaro Mato-López, Ian J. Donaldson, Alejandra Roldán, Harry Chown, Norman Van Rhijn, Rebeca Lobo-Vega, Sara Gago, Takanori Furukawa, Alma Morogovsky, Ronen Ben Ami, Paul Bowyer, Nir Osherov, Thierry Fontaine, Gustavo H. Goldman, Emilia Mellado, Michael Bromley, Jorge Amich, University of Manchester [Manchester], Universidade de São Paulo = University of São Paulo (USP), Instituto de Salud Carlos III [Madrid] (ISC), Tel Aviv University (TAU), Biologie et Pathogénicité fongiques - Fungal Biology and Pathogenicity (BPF), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade Federal de São Paulo, J.A. is funded by an Atracción de Talento Modalidad 1 (020-T1/BMD-200) contract of the Madrid Regional Government. J.S. has been funded by a BSAC Scholarship (bsac-2016-0049). C.V. was funded by FAPESP (2108/00715-3 and 2020/01131-5). G.H.G. has been funded by FAPESP (2016/07870-9 and 2021/04977-5), CNPq (301058/2019-9 and 404735/2018-5) and by the NIH/NIAID (grant R01AI153356). S.G. was cofunded by the NIHR Manchester Research Centre and the Fungal Infection Trust., Comunidad de Madrid (España), São Paulo Research Foundation, National Council for Scientific and Technological Development (Brasil), and NIH - National Institute of Allergy and Infectious Diseases (NIAID) (Estados Unidos)

Subjects
Microbiology (medical), Antifungal persistence, General Immunology and Microbiology, Ecology, Physiology, Aspergillus fumigatus, [SDV]Life Sciences [q-bio], Drug response, drug response, antifungal persistence, Cell Biology, Infectious Diseases, Treatment failure, Genetics, voriconazole, Voriconazole, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, treatment failure
Abstract

Aspergillus fumigatus is a filamentous fungus that can infect the lungs of patients with immunosuppression and/or underlying lung diseases. The mortality associated with chronic and invasive aspergillosis infections remain very high, despite availability of antifungal treatments. In the last decade, there has been a worrisome emergence and spread of resistance to the first-line antifungals, the azoles. The mortality caused by resistant isolates is even higher, and patient management is complicated as the therapeutic options are reduced. Nevertheless, treatment failure is also common in patients infected with azole-susceptible isolates, which can be due to several non-mutually exclusive reasons, such as poor drug absorption. In addition, the phenomena of tolerance or persistence, where susceptible pathogens can survive the action of an antimicrobial for extended periods, have been associated with treatment failure in bacterial infections, and their occurrence in fungal infections already proposed. Here, we demonstrate that some isolates of A. fumigatus display persistence to voriconazole. A subpopulation of the persister isolates can survive for extended periods and even grow at low rates in the presence of supra-MIC of voriconazole and seemingly other azoles. Persistence cannot be eradicated with adjuvant drugs or antifungal combinations and seemed to reduce the efficacy of treatment for certain individuals in a Galleria mellonella model of infection. Furthermore, persistence implies a distinct transcriptional profile, demonstrating that it is an active response. We propose that azole persistence might be a relevant and underestimated factor that could influence the outcome of infection in human aspergillosis. Importance: The phenomena of antibacterial tolerance and persistence, where pathogenic microbes can survive for extended periods in the presence of cidal drug concentrations, have received significant attention in the last decade. Several mechanisms of action have been elucidated, and their relevance for treatment failure in bacterial infections demonstrated. In contrast, our knowledge of antifungal tolerance and, in particular, persistence is still very limited. In this study, we have characterized the response of the prominent fungal pathogen Aspergillus fumigatus to the first-line therapy antifungal voriconazole. We comprehensively show that some isolates display persistence to this fungicidal antifungal and propose various potential mechanisms of action. In addition, using an alternative model of infection, we provide initial evidence to suggest that persistence may cause treatment failure in some individuals. Therefore, we propose that azole persistence is an important factor to consider and further investigate in A. fumigatus. J.A. is funded by an Atracción de Talento Modalidad 1 (020-T1/BMD-200) contract of the Madrid Regional Government. J.S. has been funded by a BSAC Scholarship (bsac-2016-0049). C.V. was funded by FAPESP (2108/00715-3 and 2020/01131-5). G.H.G. hasbeen funded by FAPESP (2016/07870-9 and 2021/04977-5), CNPq (301058/2019-9 and404735/2018-5) and by the NIH/NIAID (grant R01AI153356). S.G. was cofunded by the NIHR Manchester Research Centre and the Fungal Infection Trust. Sí

Published
2023

26. New Cretaceous crickets of the subfamilies Nemobiinae and Podoscirtinae (Orthoptera, Grylloidea: Trigonidiidae, Oecanthidae) attest the antiquity of these clades

Author

Laure Desutter-Grandcolas, Hugo Josse, Marie Laurent, Lucas Denadai de Campos, Sylvain Hugel, Carmen Soriano, André Nel, Vincent Perrichot, Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Muséum national d'Histoire naturelle (MNHN), Géosciences Rennes (GR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Instituto de Biociencias, Departamento de Zoologia, Universidade de São Paulo = University of São Paulo (USP), Institut des Neurosciences Cellulaires et Intégratives (INCI), and Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
taxonomy, Insecta, Ensifera, amber, [SDU]Sciences of the Universe [physics], evolutionary studies, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Geology, calibration, [SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/Paleontology, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy
Abstract

Fossils are more and more used in phylogenetic evolutionary studies either for clade calibration, or as terminals in a dataset including morphological characters. The strength of these methodological advances relies however on the quality and completeness of the fossil record. For crickets (Insecta, Orthoptera, Gryllidea), few ancient (pre-Cenozoic) well-preserved fossils are known, except for isolated wings often classified in purely fossil groups and a few fossils found in Cretaceous amber. Here, we present two remarkable fossils from mid-Cretaceous amber of France, that were imaged using X-ray synchrotron microtomography and exhibit an exquisite preservation allowing description with a precision similar to that of extant taxa. Palaeonemobius occidentalis Laurent and Desutter-Grandcolas, gen. nov., sp. nov. and Picogryllus carentonensis Josse and Desutter-Grandcolas, gen. nov., sp. nov. are the oldest representatives of the Nemobiinae and Podoscirtinae subfamilies of the Trigonidiidae and Oecanthidae families respectively. P. carentonensis Josse and Desutter-Grandcolas, gen. nov., sp. nov. is also the smallest adult male with a full stridulatory apparatus ever documented in crickets (body length 3.3 mm), and the first taxon of the cricket clade for which male genitalia can be partly described. We discuss the significance of Cretaceous fossils of crickets for future evolutionary studies of this clade.

Published
2023

27. Search for dark-matter–Nucleon interactions via Migdal effect with DarkSide-50

Author

Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Campos, M. D., Canci, N., Caravati, M., Cargioli, N., Cariello, M., Carlini, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., D’Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., D’Incecco, M., Dionisi, C., Dordei, F., Downing, M., D’Urso, D., Fairbairn, M., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G. K., Goretti, A. M., Grilli di Cortona, G., Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B. R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hungerford, E. V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C. L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I. N., Mapelli, L. P., Mari, S. M., Maricic, J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V. N., Musico, P., Nozdrina, A. O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Pocar, A., Poehlmann, D. M., Pordes, S., Poudel, S. S., Pralavorio, P., Price, D. D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sandford, E., Sands, W., Sanfilippo, S., Savarese, C., Schlitzer, B., Semenov, D. A., Shchagin, A., Sheshukov, A., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M. M., Xiao, X., Yang, C., Zuzel, G., Royal Holloway [University of London] (RHUL), Universidade de São Paulo = University of São Paulo (USP), Pacific Northwest National Laboratory (PNNL), University of South Dakota [Vermillion] (USD), Istituto Nazionale di Fisica Nucleare [Pisa] (INFN), Istituto Nazionale di Fisica Nucleare (INFN), Fermi National Accelerator Laboratory (Fermilab), Istituto Nazionale di Fisica Nucleare [Sezione di Roma 1] (INFN), Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari (INFN, Sezione di Cagliari), Università degli studi di Genova = University of Genoa (UniGe), Università degli Studi di Cagliari = University of Cagliari (UniCa), Princeton University, Istituto Nazionale di Fisica Nucleare, Sezione di Genova (INFN, Sezione di Genova), King‘s College London, Laboratori Nazionali del Gran Sasso (LNGS), University of Naples Federico II = Università degli studi di Napoli Federico II, Virginia Tech [Blacksburg], D.V. Skobeltsyn Institute of Nuclear Physics (SINP), Lomonosov Moscow State University (MSU), Università degli Studi di Milano = University of Milan (UNIMI), Saint Petersburg Nuclear Physics Institute RAS, St Petersburg Nuclear Physics Institute, University of Massachusetts System (UMASS), Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Physics, Princeton University (DPPU), INFN Frascati, Institute of Molecular Genetics of National Research Centre «Kurchatov Institute» [Moscow, Russia], Russian Academy of Sciences [Moscow] (RAS), Institute of High Energy Physics [Beijing] (IHEP), Chinese Academy of Sciences [Changchun Branch] (CAS), Università degli Studi di Enna ' KORE ' = Kore University of Enna, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), University of Houston [Clear Lake], Black Hills State University, Nicolaus Copernicus Astronomical Cente (AstroCeNT), Joint Institute for Nuclear Research (JINR), University of Houston, Belgorod National Research University, University of California (UC), University of Hawai'i [Hilo], Laboratoire National Henri Becquerel (LNHB), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département d'instrumentation Numérique (DIN (CEA-LIST)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Università degli Studi di Perugia = University of Perugia (UNIPG), Istituto Nazionale di Fisica Nucleare, Sezione di Catania (INFN), Università degli studi di Catania = University of Catania (Unict), University of Massachusetts [Amherst] (UMass Amherst), University of California [Davis] (UC Davis), University of Manchester [Manchester], Università degli Studi di Roma Tor Vergata [Roma], Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), DarkSide Collaboration, Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Campos, M. D., Canci, N., Caravati, M., Cargioli, N., Cariello, M., Carlini, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., D’Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., D’Incecco, M., Dionisi, C., Dordei, F., Downing, M., D’Urso, D., Fairbairn, M., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G. K., Goretti, A. M., Grilli di Cortona, G., Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B. R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hungerford, E. V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C. L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I. N., Mapelli, L. P., Mari, S. M., Maricic, J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V. N., Musico, P., Nozdrina, A. O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Pocar, A., Poehlmann, D. M., Pordes, S., Poudel, S. S., Pralavorio, P., Price, D. D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sandford, E., Sands, W., Sanfilippo, S., Savarese, C., Schlitzer, B., Semenov, D. A., Shchagin, A., Sheshukov, A., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M. M., Xiao, X., Yang, C., and Zuzel, G.

Subjects
instrumentation, electrons, General Physics and Astronomy, dark matter direct detection, dark matter mass, radioactivity, ionization, Dark matter, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], particle interaction, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], electron final state, ionizing radiation, signal processing, experimental results
Abstract

Dark matter elastic scattering off nuclei can result in the excitation and ionization of the recoiling atom through the so-called Migdal effect. The energy deposition from the ionization electron adds to the energy deposited by the recoiling nuclear system and allows for the detection of interactions of sub-GeV/c2 mass dark matter. We present new constraints for sub-GeV/c2 dark matter using the dual-phase liquid argon time projection chamber of the DarkSide-50 experiment with an exposure of (12 306±184) kg d. The analysis is based on the ionization signal alone and significantly enhances the sensitivity of DarkSide-50, enabling sensitivity to dark matter with masses down to 40 MeV/c2. Furthermore, it sets the most stringent upper limit on the spin independent dark matter nucleon cross section for masses below 3.6 GeV/c2.

Published
2023

28. Galectin-3 Blockade Inhibits Cardiac Inflammation and Fibrosis in Experimental Hyperaldosteronism and HypertensionNovelty and Significance

Author

Martinez-Martinez, Ernesto, Calvier, Laurent, Fernández-Celis, Amaya, Rousseau, Elodie, Jurado-López, Raquel, Rossoni, Luciana, Jaisser, Frederic, Zannad, Faiez, Rossignol, Patrick, Cachofeiro, Victoria, López-Andrés, Natalia, Fundación Miguel Servet, Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Instituto de Investigación Sanitaria Gregorio Marañón [Madrid, Spain] ( IiSGM), Universidade de Sao Paulo, Institute of Biomedical Sciences, Universidade de São Paulo (USP)-Institute of Biomedical Sciences (ICB/USP), Universidade de São Paulo (USP), Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC-Nancy, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy]-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade de São Paulo = University of São Paulo (USP)-Institute of Biomedical Sciences (ICB/USP), Universidade de São Paulo = University of São Paulo (USP), and Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE)

Subjects
aldosterone, hypertension, MESH: Humans, MESH: Rats, fibrosis, MESH: Mineralocorticoid Receptor Antagonists, MESH: Rats, Wistar, galectin 3, MESH: Mice, Knockout, MESH: Galectin 3, MESH: Hypertension, MESH: Male, MESH: Hyperaldosteronism, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, inflammation, MESH: Mice, Inbred C57BL, MESH: Myocarditis, MESH: Fibroblasts, MESH: Spironolactone, MESH: Fibrosis, MESH: Animals, MESH: Disease Models, Animal, MESH: Mice, MESH: Rats, Inbred WKY, MESH: Cells, Cultured
Abstract

International audience; Hypertensive cardiac remodeling is accompanied by molecular inflammation and fibrosis, 2 mechanisms that finally affect cardiac function. At cardiac level, aldosterone promotes inflammation and fibrosis, although the precise mechanisms are still unclear. Galectin-3 (Gal-3), a β-galactoside-binding lectin, is associated with inflammation and fibrosis in the cardiovascular system. We herein investigated whether Gal-3 inhibition could block aldosterone-induced cardiac inflammation and fibrosis and its potential role in cardiac damage associated with hypertension. Aldosterone-salt-treated rats presented hypertension, cardiac inflammation, and fibrosis that were prevented by the pharmacological inhibition of Gal-3 with modified citrus pectin. Cardiac inflammation and fibrosis presented in spontaneously hypertensive rats were prevented by modified citrus pectin treatment, whereas Gal-3 blockade did not modify blood pressure levels. In the absence of blood pressure modifications, Gal-3 knockout mice were resistant to aldosterone-induced cardiac inflammation. In human cardiac fibroblasts, aldosterone increased Gal-3 expression via its mineralocorticoid receptor. Gal-3 and aldosterone enhanced proinflammatory and profibrotic markers, as well as metalloproteinase activities in human cardiac fibroblasts, effects that were not observed in Gal-3-silenced cells treated with aldosterone. In experimental hyperaldosteronism, the increase in Gal-3 expression was associated with cardiac inflammation and fibrosis, alterations that were prevented by Gal-3 blockade independently of blood pressure levels. These data suggest that Gal-3 could be a new molecular mechanism linking cardiac inflammation and fibrosis in situations with high-aldosterone levels, such as hypertension.

Published
2015

29. Recent developments in maleic acid synthesis from bio-based chemicals

Author

Robert Wojcieszak, Francesco Santarelli, Renato V. Gonçalves, Sébastien Paul, Franck Dumeignil, Fabrizio Cavani, Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Universidade de São Paulo (USP), Wojcieszak, Robert, Santarelli, Francesco, Paul, Sébastien, Dumeignil, Franck, Cavani, Fabrizio, V Gonçalves, Renato, ENSCL, CNRS, Centrale Lille, Univ. Artois, Université de Lille, Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Alma Mater Studiorum Università di Bologna [Bologna] [UNIBO], Universidade de São Paulo = University of São Paulo [USP], Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Universidade de São Paulo = University of São Paulo (USP)

Subjects
Maleic acid, oxidation, furfural, Maleic anhydride, Bio based, Nanotechnology, [CHIM.CATA]Chemical Sciences/Catalysis, Heterogeneous catalysis, Furfural, Catalysis, chemistry.chemical_compound, maleic anhydride, chemistry, Homogeneous, Furan, Organic chemistry
Abstract

International audience; This review paper presents the current state of the art on maleic acid synthesis from biomass-derived chemicals over homogeneous or heterogeneous catalysts. It is based on the most recent publications on the topic, which are discussed in details with respect to the observed catalytic performances. The recent developments and the technical drawbacks in the gas and the liquid phases are also reported. In addition, recent results on the mechanistic aspect are discussed giving insights into the probable reaction mechanisms depending on the starting molecule (furan, furfural and 5-hydroxymethylfurfural).

Published
2015

30. An 'importance' map of signs and symptoms to classify diabetic polyneuropathy: An exploratory data analysis

Author

Cristina D. Sartor, Eneida Yuri Suda, Isabel C. N. Sacco, Vincent Vigneron, Physical Therapy, Speech and Occupational Therapy Dept., Polytechnic School [São Paulo], University of São Paulo (USP)-University of São Paulo (USP), Informatique, Biologie Intégrative et Systèmes Complexes (IBISC), Université d'Évry-Val-d'Essonne (UEVE), and Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP)

Subjects
Diabetic neuropathy, medicine.medical_treatment, [SDV]Life Sciences [q-bio], data analysis, lcsh:Medicine, Disease, 0302 clinical medicine, Diabetic Neuropathies, middle aged, syndrome delineation, lcsh:Science, Multidisciplinary, foot amputation, adult, disease course, Prognosis, diabetic neuropathy, 3. Good health, aged, female, Disease Progression, disease severity, Symptom Assessment, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Foot (unit), Research Article, medicine.medical_specialty, foot malformation, 030209 endocrinology & metabolism, vibration sense, Article, 03 medical and health sciences, Vibration perception, male, Internal medicine, Diabetes mellitus, callus, medicine, Humans, controlled study, human, clinical indicator, outcome assessment, Models, Statistical, business.industry, lcsh:R, disease association, Tactile perception, medicine.disease, Diabetic foot, major clinical study, foot ulcer, clinical feature, Amputation, Physical therapy, lcsh:Q, business, 030217 neurology & neurosurgery
Abstract

International audience; Aims/Hypothesis: Early diagnosis of diabetic polyneuropathy (DPN) is critical for a good prognosis. We aimed to identify different groups of patients, based on the various common clinical signs and symptoms of DPN, that represent a progressive worsening of the disease before the onset of plantar ulceration or amputation. We also sought to identify the most important DPN-related variables that can discriminate between groups, thus representing the most informative variables for early detection. Methods: In 193 diabetic patients, we assessed 16 DPN-related signs, symptoms, and foot characteristics, based on the literature and the International Consensus on the Diabetic Foot. We used multiple correspondence analysis and the Kohonen algorithm to group the variables into micro and macro-classes and to identify clusters of patients that represent different DPN conditions. Results: Four distinct groups were observed. One group showed no indication of DPN. The remaining groups were characterized by a progressive loss of the vibration perception, without a worsening of symptoms or tactile perception. The 2 intermediate groups presented different aspects of DPN: one showed mostly DPN symptoms and the other showed the incipient vibration impairment, callus and crack formation, and foot arch alteration. The fourth group showed more severe foot and DPN conditions, including ulceration and amputation, absence of vibration and tactile perception (irrespective of how many compromised foot areas), and worse foot deformities and callus and crack formation. Conclusion: Vibration perception was more informative than tactile sensitivity in discriminating early DPN onset because its impairment was evident in more groups. Symptoms and callus and cracks did not discriminate the severity status and should be interpreted in association with other clinical variables. Reconsideration of the current screening techniques is needed to clinically determine the early onset of neuropathy using tactile perception.

Published
2015

31. High N-content holey few-layered graphene electrocatalysts: scalable solvent-less production

Author

Ying Chen, Dan Liu, David Portehault, Weiwei Lei, Si Qin, Science et Ingénierie des Matériaux et Procédés (SIMaP), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Chimie de la Matière Condensée de Paris (site Paris VI) (LCMCP (site Paris VI)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciencias Matematicas e de Computaçao, Instituto de Ciências Mathemàticas e de Computação [São Carlos] (ICMC-USP), Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP), Australian Research Council, Discovery Early Career Researcher Award (DECRA) Research Fellowship, Central Research Grant Scheme (CRGS) from Deakin University, and Universidade de São Paulo (USP)-Universidade de São Paulo (USP)

Subjects
Materials science, Renewable Energy, Sustainability and the Environment, Graphene, Doping, chemistry.chemical_element, Nanotechnology, General Chemistry, Chemical vapor deposition, [CHIM.MATE]Chemical Sciences/Material chemistry, 7. Clean energy, Exfoliation joint, Catalysis, law.invention, chemistry, law, Yield (chemistry), General Materials Science, Graphite, Carbon
Abstract

International audience; Few layered nitrogen doped graphene (NG) attracts great interest in energy storage and conversion applications due to its electronic and catalytic properties. However, its bulk production cannot be envisioned by the current synthetic methods. Here we report a facile, solvent-less, low cost and high yield process for the synthesis of NG. Mechanochemical solid-state exfoliation allows scalable synthesis of holey and crumple nitrogen-doped few-layered graphene from graphite with controlled high concentration N doping and a high surface area through ball-milling. By adjusting the ratio of starting materials, the nitrogen content can be modulated from 4.87 to 17.83 at.%. Furthermore, the types of nitrogen-containing species in few-layered graphene can also be controlled. The resultant NG exhibits superior oxygen reduction reaction performance and more reliable stability than commercial Pt/C catalysts.

Published
2015

32. Functional IL18 polymorphism and susceptibility to Chronic Chagas Disease

Author

Ariana de Melo Borges, Virmondes Rodrigues, Monique Andrade Baron, Cristina Wide Pissetti, Christophe Chevillard, Hui-Tzu Lin Wang, Mario Hiroyuki Hirata, Abílio Fragata, Jorge Kalil, Mariana M Lensi, Charles Mady, Marcelo Ferraz Sampaio, Bruno Saba, Eduardo Antônio Donadi, Gisele de Lima Peixoto, Luciana Gabriel Nogueira, Sandrine Cabantous, José Antonio Marin-Neto, Martino Martinelli, André Schmidt, Paula Buck, Sérgio Siqueira, Laurie Laugier, Amanda Farage Frade, Alexandre C. Pereira, Fabrício Moura Dias, Edecio Cunha-Neto, Barbara Maria Ianni, Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Heart Institute (InCor), Universidade de São Paulo = University of São Paulo (USP)-Faculdade de Medicina FMUSP, School of Medicine of Ribeirão Preto (FMRP), Universidade de São Paulo = University of São Paulo (USP), Cardiologia, Instituto de Cardiologia Dante Pazzanese (IDPC), Laboratory of Immunology, Heart Institute (InCor), University of São Paulo School of Medicine, Division of Clinical Immunology and Allergy, Institute for Investigation in Immunology, iii-INCT, Génétique et immunologie des maladies parasitaires (GIMP), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo (USP)-Faculdade de Medicina FMUSP, University of São Paulo (USP), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
Chagas Cardiomyopathy, Male, Linkage disequilibrium, medicine.medical_specialty, Myocarditis, Immunology, Single-nucleotide polymorphism, Biology, POLIMORFISMO, Biochemistry, Asymptomatic, Polymorphism, Single Nucleotide, Pathogenesis, Cohort Studies, Internal medicine, medicine, Immunology and Allergy, SNP, Humans, Genetic Predisposition to Disease, Molecular Biology, Genetic Association Studies, ComputingMilieux_MISCELLANEOUS, Interleukin-18, Dilated cardiomyopathy, Stroke Volume, Hematology, medicine.disease, 3. Good health, Genotype frequency, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Case-Control Studies, Chronic Disease, Cardiology, Female, medicine.symptom
Abstract

Background Chronic Chagas Disease cardiomyopathy (CCC), a life-threatening inflammatory dilated cardiomyopathy, affects 30% of the approximately 8 million patients infected by Trypanosoma cruzi, the rest of the infected subjects remaining asymptomatic (ASY). The Th1 T cell-rich myocarditis plays a pivotal role in CCC pathogenesis. Local expression of IL-18 in CCC myocardial tissue has recently been described. IL-18 could potentially amplify the process by inducing increased expression of IFN-γ which in turn can increase the production of IL-18, thereby creating a positive feedback mechanism. In order to assess the contribution of the IL-18 to susceptibility to Chronic Chagas Disease, we investigated the association between a single nucleotide polymorphism (SNP) located in the IL-18 gene with the risk of developing Chagas cardiomyopathy. Methods and results We analyzed the rs2043055 marker in the IL18 gene in a cohort of Chagas disease cardiomyopathy patients (n = 849) and asymptomatic subjects (n = 202). We found a significant difference in genotype frequencies among moderate and severe CCC patients with ventricular dysfunction. Conclusions Our analysis suggests that the IL18 rs2043055 polymorphism- or a SNP in tight linkage disequilibrium with it- may contribute to modulating the Chagas cardiomyopathy outcome.

Published
2015

33. Diversification of tiny toads (Bufonidae: Amazophrynella) sheds light on ancient landscape dynamism in Amazonia

Author

Leandro J C L Moraes, Fernanda P Werneck, Alexandre Réjaud, Miguel T Rodrigues, Ivan Prates, Frank Glaw, Philippe J R Kok, Santiago R Ron, Juan C Chaparro, Mariela Osorno-Muñoz, Francisco Dal Vechio, Renato S Recoder, Sérgio Marques-Souza, Rommel R Rojas, Léa Demay, Tomas Hrbek, Antoine Fouquet, Instituto Nacional de Pesquisas da Amazônia (INPA), Evolution et Diversité Biologique (EDB), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], The Natural History Museum [London] (NHM), University of Puerto Rico (UPR), and Universidade Federal do Amazonas

Subjects
[SDV]Life Sciences [q-bio], Ecology, Evolution, Behavior and Systematics
Abstract

Major historical landscape changes have left significant signatures on species diversification. However, how these changes have affected the build-up and maintenance of Amazonia’s megadiversity continues to be debated. Here, we addressed this issue by focusing on the evolutionary history of a pan-Amazonian toad genus that has diversified throughout the Neogene (Amazophrynella). Based on a comprehensive spatial and taxonomic sampling (286 samples, all nominal species), we delimited operational taxonomic units (OTUs) from mitochondrial DNA sequences. We delimited 35 OTUs, among which 13 correspond to nominal species, suggesting a vast underestimation of species richness. Next, we inferred time-calibrated phylogenetic relationships among OTUs based on complete mitogenomic data, which confirmed an ancient divergence between two major clades distributed in eastern and western Amazonia, respectively. Ancestral area reconstruction analyses suggest that the Andean foothills and the Brazilian Shield region represent the ancient core areas for their diversification. These two clades, probably isolated from one other by lacustrine ecosystems in western Amazonia during the Miocene, display a pattern of northward and eastward dispersals throughout the Miocene‒Pliocene. Given the ecological association of Amazophrynella with non-flooded forests, our results reinforce the perception that ancient Amazonian landscape changes had a major impact on the diversification of terrestrial vertebrates.

Published
2022

34. Assessment of the relationship between the MLST genetic diversity of Listeria monocytogenes and growth under selective and non-selective conditions

Author

Rosa Rodrigues de Souza, Carolina, Bergis, Hélène, Ng, Patricia, Guillier, Laurent, Félix, Benjamin, Leclercq, Alexandre, Gnanou-Besse, Nathalie, Laboratoire de sécurité des aliments de Maisons-Alfort (LSAl), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), Universidade de São Paulo = University of São Paulo (USP), Direction de l'Evaluation des Risques (DER), and Institut Pasteur [Paris] (IP)

Subjects
Clonal complex, [SDV]Life Sciences [q-bio], Growth, Listeria monocytogenes, Selective enrichment, Microbiology, MLST, Food Science
Abstract

International audience; Listeria monocytogenes can grow under stressful conditions and contaminate various food categories. Progresss in DNA sequencing-based identification methods, such as multi-locus sequence typing (MLST) now allow for more accurate characterization of pathogens. L. monocytogenes MLST genetic diversity is reflected by the different prevalence of the "clonal complexes" (CCs) in foods or infections. Better understanding of the growth potentials of L. monocytogenes is essential for quantitative risk assessment and efficient detection across CCs genetic diversity. Using optical density measurements taken with an automated spectrophotometer, we compared the maximal growth rate and lag phase of 39 strains from 13 different CCs and various food origins, in 3 broths mimicking stresful food conditions (8 °C, aw 0.95 and pH5) and in ISO Standard enrichment broths (Half Fraser and Fraser). This is important as growth could influence risk through pathogen multiplication in food. Besides, enrichment problems could lead to a lack of detection of some CCs. Despite small differences highlighting natural intraspecific variability, our results show that growth performances of L. monocytogenes strains under the conditions tested in selective and non-selective broth do not appear to be strongly correlated to CCs and cannot explain higher CC "virulence" or prevalence.

Published
2023

35. KDM1A inactivation causes hereditary food-dependent Cushing syndrome

Author

Lucas Bouys, Guillaume Assié, Anna Vaczlavik, Florian Violon, Constantine A. Stratakis, Eric Letouzé, Maria Candida Barisson Villares Fragoso, Patricia Vaduva, Jérôme Bertherat, Marie-Odile North, Mathilde Sibony, Stéphanie Espiard, Rossella Libé, Magalie Haissaguerre, Roberta Armignacco, Bertrand Dousset, Laurence Guignat, Karine Perlemoine, Lionel Groussin, Anne Jouinot, Annabel Berthon, Christopher Ribes, Bruno Ragazzon, Martin Reincke, Fidéline Bonnet, Gaetan Giannone, Eric Pasmant, Igor Tauveron, Philippe Emy, Isadora Pontes Cavalcante, Maxime Barat, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe, Mines Paris - PSL (École nationale supérieure des mines de Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), CHU Pontchaillou [Rennes], CHU Lille, Centre Hospitalier Régional d'Orléans (CHRO), Université de Bordeaux (UB), CHU Bordeaux [Bordeaux], CHU Clermont-Ferrand, Universidade de São Paulo = University of São Paulo (USP), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, ANR-18-CE14-0008,STEROMICS,Steroïdogénomique de l'hypersécrétion des stéroïdes surrénaliens(2018), Admin, Oskar, and APPEL À PROJETS GÉNÉRIQUE 2018 - Steroïdogénomique de l'hypersécrétion des stéroïdes surrénaliens - - STEROMICS2018 - ANR-18-CE14-0008 - AAPG2018 - VALID

Subjects
medicine.medical_treatment, Adrenocortical tumors, ARMC5, Germline, Cushing syndrome, medicine, Humans, Allele, Cushing Syndrome, GIPR, Genetics (clinical), Exome sequencing, Armadillo Domain Proteins, Histone Demethylases, Hyperplasia, business.industry, Adrenalectomy, medicine.disease, Phenotype, KDM1A, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Macronodular Adrenal Hyperplasia, DNA methylation, Cancer research, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Ectopic expression, business
Abstract

International audience; PURPOSE: This study aimed to investigate the genetic cause of food-dependent Cushing syndrome (FDCS) observed in patients with primary bilateral macronodular adrenal hyperplasia (PBMAH) and adrenal ectopic expression of the glucose-dependent insulinotropic polypeptide receptor. Germline ARMC5 alterations have been reported in about 25% of PBMAH index cases but are absent in patients with FDCS. METHODS: A multiomics analysis of PBMAH tissues from 36 patients treated by adrenalectomy was performed (RNA sequencing, single-nucleotide variant array, methylome, miRNome, exome sequencing). RESULTS: The integrative analysis revealed 3 molecular groups with different clinical features, namely G1, comprising 16 patients with ARMC5 inactivating variants; G2, comprising 6 patients with FDCS with glucose-dependent insulinotropic polypeptide receptor ectopic expression; and G3, comprising 14 patients with a less severe phenotype. Exome sequencing revealed germline truncating variants of KDM1A in 5 G2 patients, constantly associated with a somatic loss of the KDM1A wild-type allele on 1p, leading to a loss of KDM1A expression both at messenger RNA and protein levels (P = 1.2 × 10(-12) and P < .01, respectively). Subsequently, KDM1A pathogenic variants were identified in 4 of 4 additional index cases with FDCS. CONCLUSION: KDM1A inactivation explains about 90% of FDCS PBMAH. Genetic screening for ARMC5 and KDM1A can now be offered for most PBMAH operated patients and their families, opening the way to earlier diagnosis and improved management.

Published
2022

36. Are nanomaterials leading to more efficient agriculture? Outputs from 2009 to 2022 research metadata analysis

Author

E. Santos, G. S. Montanha, M. H. F. Gomes, N. M. Duran, C. G. Corrêa, S. L. Z. Romeu, A. E.S. Pereira, J. L. Oliveira, E. Almeida, A. Pérez-de-Luque, S. Ghoshal, C. Santaella, R. de Lima, L. F. Fraceto, H. W. P. Carvalho, Universidade de São Paulo = University of São Paulo (USP), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), Universidade de Lisboa = University of Lisbon (ULISBOA), IFAPA Centro Alameda del Obispo, Instituto Andaluz de Investigación y Formación Agraria y Pesquera (IFAPA), McGill University = Université McGill [Montréal, Canada], Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Faculdade de Engenharia de Sorocaba

Subjects
Materials Science (miscellaneous), [SDE]Environmental Sciences, PLANTAS CULTIVADAS, General Environmental Science
Abstract

International audience; Agriculture is responsible for supplying food, feed, fibres, and an increasing fraction of fuel and raw chemicals for industry. Fulfilling such demands sustainably is one of the major challenges of our time. In this metadata analysis, we offer a quantitative overview of how scientists have been addressing the effects of nanomaterials on plants between 2009 and 2022. The analysis showed that cultivated crops (55%) and plant nutrients (52%) are mostly employed in the studies, pointing to the relevance of these aspects to agriculture. Nevertheless, it also revealed that the concentration of elements as nanomaterials is, generally, more than 2-fold higher than the elemental concentration applied as traditionally formulated fertilisers or those naturally found in soil. Furthermore, the median time span of most studies, i.e., 49 days for plants cultivated in soil, is still quite short compared to annual crop life cycles (90-120 days), and little attention (19% of treatments) has been devoted to soil microorganisms. Also, only a small fraction of experiments (6%) has been carried out under field conditions. Therefore, the data did not allow establishing correlations between effects and experimental parameters, such as concentration range, soil pH, or time of exposure. These observations point to the intricate relationship between our ability to infer conclusions and the experimental design employed. Finally, this comprehensive and up-to-date overview of the effects of nanomaterials in plant systems raises the question of whether nanomaterials will lead to incremental yield gains by replacing current inputs with nanotechnology-based ones, such as the controlled release of fertilizers and pesticides, or it will disrupt agriculture by attacking problems so far not practically addressed, such as hacking plant stress and defence mechanisms or modulating metabolism and photosystems.

Published
2022

37. PDRs4All: A JWST Early Release Science Program on Radiative Feedback from Massive Stars

Author

Olivier Berné, Émilie Habart, Els Peeters, Alain Abergel, Edwin A. Bergin, Jeronimo Bernard-Salas, Emeric Bron, Jan Cami, Emmanuel Dartois, Asunción Fuente, Javier R. Goicoechea, Karl D. Gordon, Yoko Okada, Takashi Onaka, Massimo Robberto, Markus Röllig, Alexander G. G. M. Tielens, Sílvia Vicente, Mark G. Wolfire, Felipe Alarcón, C. Boersma, Amélie Canin, Ryan Chown, Daniel Dicken, David Languignon, Romane Le Gal, Marc W. Pound, Boris Trahin, Thomas Simmer, Ameek Sidhu, Dries Van De Putte, Sara Cuadrado, Claire Guilloteau, Alexandros Maragkoudakis, Bethany R. Schefter, Thiébaut Schirmer, Stéphanie Cazaux, Isabel Aleman, Louis Allamandola, Rebecca Auchettl, Giuseppe Antonio Baratta, Salma Bejaoui, Partha P. Bera, Goranka Bilalbegović, John H. Black, Francois Boulanger, Jordy Bouwman, Bernhard Brandl, Philippe Brechignac, Sandra Brünken, Andrew Burkhardt, Alessandra Candian, Jose Cernicharo, Marin Chabot, Shubhadip Chakraborty, Jason Champion, Sean W. J. Colgan, Ilsa R. Cooke, Audrey Coutens, Nick L. J. Cox, Karine Demyk, Jennifer Donovan Meyer, Cécile Engrand, Sacha Foschino, Pedro García-Lario, Lisseth Gavilan, Maryvonne Gerin, Marie Godard, Carl A. Gottlieb, Pierre Guillard, Antoine Gusdorf, Patrick Hartigan, Jinhua He, Eric Herbst, Liv Hornekaer, Cornelia Jäger, Eduardo Janot-Pacheco, Christine Joblin, Michael Kaufman, Francisca Kemper, Sarah Kendrew, Maria S. Kirsanova, Pamela Klaassen, Collin Knight, Sun Kwok, Álvaro Labiano, Thomas S.-Y. Lai, Timothy J. Lee, Bertrand Lefloch, Franck Le Petit, Aigen Li, Hendrik Linz, Cameron J. Mackie, Suzanne C. Madden, Joëlle Mascetti, Brett A. McGuire, Pablo Merino, Elisabetta R. Micelotta, Karl Misselt, Jon A. Morse, Giacomo Mulas, Naslim Neelamkodan, Ryou Ohsawa, Alain Omont, Roberta Paladini, Maria Elisabetta Palumbo, Amit Pathak, Yvonne J. Pendleton, Annemieke Petrignani, Thomas Pino, Elena Puga, Naseem Rangwala, Mathias Rapacioli, Alessandra Ricca, Julia Roman-Duval, Joseph Roser, Evelyne Roueff, Gaël Rouillé, Farid Salama, Dinalva A. Sales, Karin Sandstrom, Peter Sarre, Ella Sciamma-O’Brien, Kris Sellgren, Matthew J. Shannon, Sachindev S. Shenoy, David Teyssier, Richard D. Thomas, Aditya Togi, Laurent Verstraete, Adolf N. Witt, Alwyn Wootten, Nathalie Ysard, Henning Zettergren, Yong Zhang, Ziwei E. Zhang, Junfeng Zhen, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), University of Western Ontario (UWO), Carl Sagan Center, SETI Institute, University of Michigan [Ann Arbor], University of Michigan System, Analytic and Computational Research, Inc. - Earth Sciences (ACRI-ST), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres (LERMA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatorio Astronomico Nacional, Madrid, Instituto de Física Fundamental [Madrid] (IFF), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universiteit Gent = Ghent University (UGENT), Space Telescope Science Institute (STSci), Physikalisches Institut [Köln], Universität zu Köln = University of Cologne, Meisei University, The University of Tokyo (UTokyo), Leiden Observatory [Leiden], Universiteit Leiden, Johns Hopkins University (JHU), Instituto de Astrofísica e Ciências do Espaço (IASTRO), University of Maryland [College Park], University of Maryland System, NASA Ames Research Center (ARC), Institut de Planétologie et d'Astrophysique de Grenoble (IPAG), Centre National d'Études Spatiales [Toulouse] (CNES)-Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France -Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), Signal et Communications (IRIT-SC), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Institut National Polytechnique (Toulouse) (Toulouse INP), Onsala Space Observatory (OSO), Chalmers University of Technology [Göteborg], Delft University of Technology (TU Delft), Universidade Federal de Itajubá, Bay Area Environmental Research Institute (BAER), Australian Synchrotron [Clayton], INAF - Osservatorio Astrofisico di Catania (OACT), Istituto Nazionale di Astrofisica (INAF), University of Zagreb, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), University of Colorado [Boulder], Institute for Molecules and Materials [Nijmegen], Radboud University [Nijmegen], Wellesley College, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), University of British Columbia (UBC), National Radio Astronomy Observatory [Charlottesville] (NRAO), National Radio Astronomy Observatory (NRAO), European Space Astronomy Centre (ESAC), Agence Spatiale Européenne = European Space Agency (ESA), Harvard-Smithsonian Center for Astrophysics (CfA), Harvard University-Smithsonian Institution, Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Rice University [Houston], Yunnan Observatories, Chinese Academy of Sciences [Changchun Branch] (CAS), Universidad de Chile = University of Chile [Santiago] (UCHILE), University of Virginia, Aarhus University [Aarhus], Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Instituto de Astronomia, Geofísica e Ciências Atmosféricas [São Paulo] (IAG), Universidade de São Paulo = University of São Paulo (USP), San Jose State University [San Jose] (SJSU), European Southern Observatory (ESO), Academia Sinica Institute of Astronomy and Astrophysics (ASIAA), Academia Sinica, Institute of Astronomy of the Russian Academy of Sciences (INASAN), Russian Academy of Sciences [Moscow] (RAS), UK Astronomy Technology Centre (UK ATC), Science and Technology Facilities Council (STFC), Telespazio, Services par satellites, Infrared Processing and Analysis Center (IPAC), California Institute of Technology (CALTECH), University of Missouri [Columbia] (Mizzou), University of Missouri System, Max Planck Institute for Astronomy (MPIA), CAS Key Laboratory of Crust–Mantle Materials and Environments [Hefei], School of Earth and Space Sciences [Hefei], University of Science and Technology of China [Hefei] (USTC)-University of Science and Technology of China [Hefei] (USTC)-Chinese Academy of Sciences [Beijing] (CAS), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), University of California [Berkeley] (UC Berkeley), University of California (UC), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Massachusetts Institute of Technology (MIT), Instituto de Ciencia de Materiales de Madrid (ICMM), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Steward Observatory, University of Arizona, INAF - Osservatorio Astronomico di Cagliari (OAC), United Arab Emirates University (UAEU), National Astronomical Observatory of Japan (NAOJ), Banaras Hindu University [Varanasi] (BHU), University of Amsterdam [Amsterdam] (UvA), Laboratoire de Chimie et Physique Quantiques Laboratoire (LCPQ), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche « Matière et interactions » (FeRMI), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), University of California [San Diego] (UC San Diego), University of Nottingham, UK (UON), Ohio State University [Columbus] (OSU), Space Science Institute [Boulder] (SSI), Stockholm University, Texas State University, Ritter Astrophysical Research Center, University of Toledo, National Sun Yat-Sen University (NSYSU), Star and Planet Formation Laboratory, ITA, USA, GBR, FRA, DEU, ESP, AUS, BEL, BRA, CHL, TWN, HRV, DNK, JPN, IND, NLD, PRT, CHN, RUS, SWE, National Aeronautics and Space Administration (US), University of Maryland, University of Michigan, Centre National de la Recherche Scientifique (France), Centre National D'Etudes Spatiales (France), Natural Sciences and Engineering Research Council of Canada, Ministerio de Ciencia e Innovación (España), German Research Foundation, Japan Society for the Promotion of Science, San José State University Research Foundation, Berné, Olivier, Habart, Émilie, Peeters, Els, Abergel, Alain, Bergin, Edwin A., Bernard-Salas, Jeronimo, Bron, Emeric, Cami, Jan, Dartois, Emmanuel, Fuente, Asunción, Goicoechea, Javier R., Gordon, Karl D., Okada, Yoko, Onaka, Takashi, Robberto, Massimo, Röllig, Markus, Tielens, Alexander G.G.M., Vicente, Sílvia, Wolfire, Mark G., Alarcón, Felipe, Boersma, C., Canin, Amélie, Chown, Ryan, Dicken, Daniel, Le Gal, Romane, Pound, Marc W., Trahin, Boris, Sidhu, Ameek, Van De Putte, Dries, Cuadrado, Sara, Guilloteau, Claire, Maragkoudakis, Alexandros, Schefter, Bethany R., Schirmer, Thiébaut, Aleman, Isabel, Allamandola, Louis, Auchettl, Rebecca, Antonio Baratta, Giuseppe, Bejaoui, Salma, Bera, Partha P., Bilalbegović, Goranka, Black, John H., Boulanger, Francois, Bouwman, Jordy, Brandl, Bernhard, Brünken, Sandra, Burkhardt, Andrew, Candian, Alessandra, Cernicharo, José, Chakraborty, Shubhadip, Champion, Jason, Colgan, Sean W.J., Cooke, Ilsa R., Coutens, Audrey, Cox, Nick L.J., Demyk, Karine, Donovan Meyer, Jennifer, Engrand, Cécile, Foschino, Sacha, Gavilan, Lisseth, Gerin, Maryvonne, Godard, Marie, Gottlieb, Carl A., Guillard, Pierre, Gusdorf, Antoine, Hartigan, Patrick, He, Jinhua, Herbst, Eric, Hornekaer, Liv, Janot-Pacheco, Eduardo, Joblin, Christine, Kaufman, Michael, Kemper, Francisca, Kendrew, Sarah, Kirsanova, Maria S., Klaassen, Pamela, Knight, Collin, Kwok, Sun, Labiano, Álvaro, Lai, Thomas S.Y., Lee, Timothy J., Lefloch, Bertrand, Le Petit, Franck, Li, Aigen, Linz, Hendrik, MacKie, Cameron J., Madden, Suzanne C., Mascetti, Joëlle, McGuire, Brett A., Merino, Pablo, Micelotta, Elisabetta R., Morse, Jon A., Molecular Spectroscopy (HIMS, FNWI), and HIMS (FNWI)

Subjects
Gaseous Nebulae, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, FELIX Infrared and Terahertz Spectroscopy, Star Forming Regions, Astrophysics - Astrophysics of Galaxies, Infrared Telescopes, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Astrophysics::Solar and Stellar Astrophysics, [INFO]Computer Science [cs], Photodissociation Regions, Astrophysics::Earth and Planetary Astrophysics, Polycyclic Aromatic Hydrocarbons, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], James Webb Space Telescope (JWST), Photo-Dissociation Regions (PDRs), Massive stars, Orion Bar, MIRI, NIRSpec, NIRCam, Astrophysics::Galaxy Astrophysics
Abstract

22 pags., 8 figs., 1 tab., Massive stars disrupt their natal molecular cloud material through radiative and mechanical feedback processes. These processes have profound effects on the evolution of interstellar matter in our Galaxy and throughout the universe, from the era of vigorous star formation at redshifts of 1-3 to the present day. The dominant feedback processes can be probed by observations of the Photo-Dissociation Regions (PDRs) where the far-ultraviolet photons of massive stars create warm regions of gas and dust in the neutral atomic and molecular gas. PDR emission provides a unique tool to study in detail the physical and chemical processes that are relevant for most of the mass in inter-and circumstellar media including diffuse clouds, proto-planetary disks, and molecular cloud surfaces, globules, planetary nebulae, and star-forming regions. PDR emission dominates the infrared (IR) spectra of star-forming galaxies. Most of the Galactic and extragalactic observations obtained with the James Webb Space Telescope (JWST) will therefore arise in PDR emission. In this paper we present an Early Release Science program using the MIRI, NIRSpec, and NIRCam instruments dedicated to the observations of an emblematic and nearby PDR: the Orion Bar. These early JWST observations will provide template data sets designed to identify key PDR characteristics in JWST observations. These data will serve to benchmark PDR models and extend them into the JWST era. We also present the Science-Enabling products that we will provide to the community. These template data sets and Science-Enabling products will guide the preparation of future proposals on star-forming regions in our Galaxy and beyond and will facilitate data analysis and interpretation of forthcoming JWST observations., Support for JWST-ERS program ID 1288 was provided through grants from the STScI under NASA contract NAS5-03127 to STScI (K.G., D.V.D.P., M.R.), Univ. of Maryland (M.W., M.P.), Univ. of Michigan (E.B., F.A.), and Univ. of Toledo (T.S.-Y.L.). O.B. and E.H. are supported by the Programme National “Physique et Chimie du Milieu Interstellaire” (PCMI) of CNRS/INSU with INC/INP co-funded by CEA and CNES, and through APR grants 6315 and 6410 provided by CNES. E. P. and J.C. acknowledge support from the National Science and Engineering Council of Canada (NSERC) Discovery Grant program (RGPIN-2020-06434 and RGPIN-2021-04197 respectively). E.P. acknowledges support from a Western Strategic Support Accelerator Grant (ROLA ID 0000050636). J.R.G. and S.C. thank the Spanish MCINN for funding support under grant PID2019-106110GB-I00. Work by M.R. and Y.O. is carried out within the Collaborative Research Centre 956, subproject C1, funded by the Deutsche Forschungsgemeinschaft (DFG)—project ID 184018867. T.O. acknowledges support from JSPS Bilateral Program, grant No. 120219939. M.P. and M.W. acknowledge support from NASA Astrophysics Data Analysis Program award #80NSSC19K0573. C.B. is grateful for an appointment at NASA Ames Research Center through the San José State University Research Foundation (NNX17AJ88A) and acknowledges support from the Internal Scientist Funding Model (ISFM) Directed Work Package at NASA Ames titled: “Laboratory Astrophysics—The NASA Ames PAH IR Spectroscopic Database.”

Published
2022

38. Potential of Bioassays to Assess Consequences of Cultivation of Acacia mangium Trees on Nitrogen Bioavailability to Eucalyptus Trees: Two Case-Studies in Contrasting Tropical Soils

Author

Kittima Waithaisong, Agnès Robin, Louis Mareschal, Jean-Pierre Bouillet, Jean-Michel Harmand, Bruno Bordron, Jean-Paul Laclau, José Leonardo Moraes Gonçalves, Claude Plassard, Ecologie fonctionnelle et biogéochimie des sols et des agro-écosystèmes (UMR Eco&Sols), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Escola Superior de Agricultura 'Luiz de Queiroz' (ESALQ), Universidade de São Paulo = University of São Paulo (USP), Centre de Recherche sur la Durabilité et la Productivité des Plantations Industrielles (Dispositif en Partenariat) (CRDPI), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-UR Génétique Amélioration Diversité, Cirad Direction Générale (Cirad-DG), Universidade Estadual Paulista Júlio de Mesquita Filho = São Paulo State University (UNESP), National Institute of Biology [Ljubljana] (NIB), Ministry of Science and Technology and Silpakorn University for PhD project., ANR-10-STRA-0004,Intens&Fix,Intensification écologique des écosystèmes de plantations forestières. Modélisation biophysique et évaluation socio-économique de l'association d'espèces fixatrices d'azote(2010), and ANR-10-LABX-0004,CeMEB,Mediterranean Center for Environment and Biodiversity(2010)

Subjects
Ecology, [SDV.SA.SF]Life Sciences [q-bio]/Agricultural sciences/Silviculture, forestry, N2-fixing tree species, soil N-mineralization rate, N 2 -fixing tree species, Plant Science, [SDV.SA.SDS]Life Sciences [q-bio]/Agricultural sciences/Soil study, plant N accumulation, Ecology, Evolution, Behavior and Systematics, soil respiration rate
Abstract

International audience; We hypothesized that the nitrogen-fixing tree Acacia mangium could improve the growth and nitrogen nutrition of non-fixing tree species such as Eucalyptus. We measured the N-mineralization and respiration rates of soils sampled from plots covered with Acacia, Eucalyptus or native vegetation at two tropical sites (Itatinga in Brazil and Kissoko in the Congo) in the laboratory. We used a bioassay to assess N bioavailability to eucalypt seedlings grown with and without chemical fertilization for at least 6 months. At each site, Eucalyptus seedling growth and N bioavailability followed the same trends as the N-mineralization rates in soil samples. However, despite lower soil N-mineralization rates under Acacia in the Congo than in Brazil, Eucalyptus seedling growth and N bioavailability were much greater in the Congo, indicating that bioassays in pots are more accurate than N-mineralization rates when predicting the growth of eucalypt seedlings. Hence, in the Congo, planting Acacia mangium could be an attractive option to maintain the growth and N bioavailability of the non-fixing species Eucalyptus while decreasing chemical fertilization. Plant bioassays could help determine if the introduction of N 2-fixing trees will improve the growth and mineral nutrition of non-fixing tree species in tropical planted forests.

Published
2023

39. Gaia Data Release 3: The extragalactic content

Author

Bailer-Jones, C.A. L., Teyssier, D., Delchambre, L., Ducourant, C., Garabato, D., Hatzidimitriou, D., Klioner, S.A., Rimoldini, L., Bellas-Velidis, I., Carballo, R., Carnerero, M.I., Diener, C., Fouesneau, M., Galluccio, L., Gavras, P., Krone-Martins, A., Raiteri, C.M., Teixeira, R., Brown, A.G. A., Vallenari, A., Prusti, T., de Bruijne, J.H. J., Arenou, F., Babusiaux, C., Biermann, M., Creevey, O.L., Evans, D.W., Eyer, L., Guerra, R., Hutton, A., Jordi, C., Lammers, U.L., Lindegren, L., Luri, X., Mignard, F., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Soubiran, C., Tanga, P., Walton, N.A., Bastian, U., Drimmel, R., Jansen, F., Katz, D., Lattanzi, M.G., van Leeuwen, F., Bakker, J., Cacciari, C., Castañeda, J., De Angeli, F., Fabricius, C., Frémat, Y., Guerrier, A., Heiter, U., Masana, E., Messineo, R., Mowlavi, N., Nicolas, C., Nienartowicz, K., Pailler, F., Panuzzo, P., Riclet, F., Roux, W., Seabroke, G.M., Sordo, R., Thévenin, F., Gracia-Abril, G., Portell, J., Altmann, M., Andrae, R., Audard, M., Benson, K., Berthier, J., Blomme, R., Burgess, P.W., Busonero, D., Busso, G., Cánovas, H., Carry, B., Cellino, A., Cheek, N., Clementini, G., Damerdji, Y., Davidson, M., de Teodoro, P., Campos, M. Nuñez, Dell'Oro, A., Esquej, P., Fernández-Hernández, J., Fraile, E., García-Lario, P., Gosset, E., Haigron, R., Halbwachs, J.-L., Hambly, N.C., Harrison, D.L., Hernández, J., Hestroffer, D., Hodgkin, S.T., Holl, B., Janßen, K., de Fombelle, G. Jevardat, Jordan, S., Lanzafame, A.C., Löffler, W., Marchal, O., Marrese, P.M., Moitinho, A., Muinonen, K., Osborne, P., Pancino, E., Pauwels, T., Recio-Blanco, A., Reylé, C., Riello, M., Roegiers, T., Rybizki, J., Sarro, L.M., Siopis, C., Smith, M., Sozzetti, A., Utrilla, E., van Leeuwen, M., Abbas, U., Ábrahám, P., Aramburu, A. Abreu, Aerts, C., Aguado, J.J., Ajaj, M., Aldea-Montero, F., Altavilla, G., Álvarez, M.A., Alves, J., Anderson, R.I., Varela, E. Anglada, Antoja, T., Baines, D., Baker, S.G., Balaguer-Núñez, L., Balbinot, E., Balog, Z., Barache, C., Barbato, D., Barros, M., Barstow, M.A., Bartolomé, S., Bassilana, J.-L., Bauchet, N., Becciani, U., Bellazzini, M., Berihuete, A., Bernet, M., Bertone, S., Bianchi, L., Binnenfeld, A., Blanco-Cuaresma, S., Boch, T., Bombrun, A., Bossini, D., Bouquillon, S., Bragaglia, A., Bramante, L., Breedt, E., Bressan, A., Brouillet, N., Brugaletta, E., Bucciarelli, B., Burlacu, A., Butkevich, A.G., Buzzi, R., Caffau, E., Cancelliere, R., Cantat-Gaudin, T., Carlucci, T., Carrasco, J.M., Casamiquela, L., Castellani, M., Castro-Ginard, A., Chaoul, L., Charlot, P., Chemin, L., Chiaramida, V., Chiavassa, A., Chornay, N., Comoretto, G., Contursi, G., Cooper, W.J., Cornez, T., Cowell, S., Crifo, F., Cropper, M., Crosta, M., Crowley, C., Dafonte, C., Dapergolas, A., David, P., de Laverny, P., De Luise, F., De March, R., De Ridder, J., de Souza, R., de Torres, A., del Peloso, E.F., del Pozo, E., Delbo, M., Delgado, A., Delisle, J.-B., Demouchy, C., Dharmawardena, T.E., Diakite, S., Distefano, E., Dolding, C., Enke, H., Fabre, C., Fabrizio, M., Faigler, S., Fedorets, G., Fernique, P., Figueras, F., Fournier, Y., Fouron, C., Fragkoudi, F., Gai, M., Garcia-Gutierrez, A., Garcia-Reinaldos, M., García-Torres, M., Garofalo, A., Gavel, A., Gerlach, E., Geyer, R., Giacobbe, P., Gilmore, G., Girona, S., Giuffrida, G., Gomel, R., Gomez, A., González-Núñez, J., González-Santamaría, I., González-Vidal, J.J., Granvik, M., Guillout, P., Guiraud, J., Gutiérrez-Sánchez, R., Guy, L.P., Hauser, M., Haywood, M., Helmer, A., Helmi, A., Sarmiento, M.H., Hidalgo, S.L., Hilger, T., Hładczuk, N., Hobbs, D., Holland, G., Huckle, H.E., Jardine, K., Jasniewicz, G., Piccolo, A. Jean-Antoine, Jiménez-Arranz, Ó., Campillo, J. Juaristi, Julbe, F., Karbevska, L., Kervella, P., Khanna, S., Kontizas, M., Kordopatis, G., Korn, A.J., Kóspál, Á., Kostrzewa-Rutkowska, Z., Kruszynska, K., Kun, M., Laizeau, P., Lambert, S., Lanza, A.F., Lasne, Y., Le Campion, J.-F., Lebreton, Y., Lebzelter, T., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Liao, S., Licata, E.L., Lindstrøm, H.E. P., Lister, T.A., Livanou, E., Lobel, A., Lorca, A., Loup, C., Pardo, P. Madrero, Romeo, A. Magdaleno, Managau, S., Mann, R.G., Manteiga, M., Marchant, J.M., Marconi, M., Marcos, J., Santos, M.M.S. Marcos, Pina, D. Marín, Marinoni, S., Marocco, F., Marshall, D.J., Polo, L. Martin, Martín-Fleitas, J.M., Marton, G., Mary, N., Masip, A., Massari, D., Mastrobuono-Battisti, A., Mazeh, T., McMillan, P.J., Messina, S., Michalik, D., Millar, N.R., Mints, A., Molina, D., Molinaro, R., Molnár, L., Monari, G., Monguió, M., Montegriffo, P., Montero, A., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morris, D., Muraveva, T., Murphy, C.P., Musella, I., Nagy, Z., Noval, L., Ocaña, F., Ogden, A., Ordenovic, C., Osinde, J.O., Pagani, C., Pagano, I., Palaversa, L., Palicio, P.A., Pallas-Quintela, L., Panahi, A., Payne-Wardenaar, S., Esteller, X. Peñalosa, Penttilä, A., Pichon, B., Piersimoni, A.M., Pineau, F.-X., Plachy, E., Plum, G., Poggio, E., Prša, A., Pulone, L., Racero, E., Ragaini, S., Rainer, M., Ramos, P., Ramos-Lerate, M., Fiorentin, P. Re, Regibo, S., Richards, P.J., Diaz, C. Rios, Ripepi, V., Riva, A., Rix, H.-W., Rixon, G., Robichon, N., Robin, A.C., Robin, C., Roelens, M., Rogues, H.R. O., Rohrbasser, L., Romero-Gómez, M., Rowell, N., Royer, F., Mieres, D. Ruz, Rybicki, K.A., Sadowski, G., Núñez, A. Sáez, Sellés, A. Sagristà, Sahlmann, J., Salguero, E., Samaras, N., Gimenez, V. Sanchez, Sanna, N., Santoveña, R., Sarasso, M., Schultheis, M., Sciacca, E., Segol, M., Segovia, J.C., Ségransan, D., Semeux, D., Shahaf, S., Siddiqui, H.I., Siebert, A., Siltala, L., Silvelo, A., Slezak, E., Slezak, I., Smart, R.L., Snaith, O.N., Solano, E., Solitro, F., Souami, D., Souchay, J., Spagna, A., Spina, L., Spoto, F., Steele, I.A., Steidelmüller, H., Stephenson, C.A., Süveges, M., Surdej, J., Szabados, L., Szegedi-Elek, E., Taris, F., Taylor, M.B., Tolomei, L., Tonello, N., Torra, F., Torra, J., Torralba Elipe, G., Trabucchi, M., Tsounis, A.T., Turon, C., Ulla, A., Unger, N., Vaillant, M.V., van Dillen, E., van Reeven, W., Vanel, O., Vecchiato, A., Viala, Y., Vicente, D., Voutsinas, S., Weiler, M., Wevers, T., Wyrzykowski, Ł., Yoldas, A., Yvard, P., Zhao, H., Zorec, J., Zucker, S., Zwitter, T., Max Planck Institute for Astronomy (MPIA), Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Universidade da Coruña, Foundation for Research and Technology-Hellas, Foundation for Research and Technology - Hellas (FORTH), Technische Universität Dresden = Dresden University of Technology (TU Dresden), National Observatory of Athens (NOA), Max-Planck Institute for Astronomy, Konigstuhl 17, D-69117, Heidelberg, Germany, Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astrofisico di Torino (OATo), Istituto Nazionale di Astrofisica (INAF), Instituto de Astronomia, Geofísica e Ciências Atmosféricas [São Paulo] (IAG), Universidade de São Paulo = University of São Paulo (USP), University of Manchester, INAF - Osservatorio Astronomico di Padova (OAPD), Institut de Physique de Rennes (IPR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), HEP, INSPIRE, Laboratoire Univers et Particules de Montpellier (LUPM), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Gaia

Subjects
Astrophysics and Astronomy, general [quasars], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], astro-ph.GA, Astrophysics::High Energy Astrophysical Phenomena, Astronomy, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, surveys, Space and Planetary Science, Astrophysics of Galaxies (astro-ph.GA), Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], [PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph], Astrophysics::Galaxy Astrophysics, general [galaxies]
Abstract

The Gaia Galactic survey mission is designed and optimized to obtain astrometry, photometry, and spectroscopy of nearly two billion stars in our Galaxy. Yet as an all-sky multi-epoch survey, Gaia also observes several million extragalactic objects down to a magnitude of G~21 mag. Due to the nature of the Gaia onboard selection algorithms, these are mostly point-source-like objects. Using data provided by the satellite, we have identified quasar and galaxy candidates via supervised machine learning methods, and estimate their redshifts using the low resolution BP/RP spectra. We further characterise the surface brightness profiles of host galaxies of quasars and of galaxies from pre-defined input lists. Here we give an overview of the processing of extragalactic objects, describe the data products in Gaia DR3, and analyse their properties. Two integrated tables contain the main results for a high completeness, but low purity (50-70%), set of 6.6 million candidate quasars and 4.8 million candidate galaxies. We provide queries that select purer sub-samples of these containing 1.9 million probable quasars and 2.9 million probable galaxies (both 95% purity). We also use high quality BP/RP spectra of 43 thousand high probability quasars over the redshift range 0.05-4.36 to construct a composite quasar spectrum spanning restframe wavelengths from 72-100 nm., Accepted to A&A

Published
2023

40. Shearless curve breakup in the biquadratic nontwist map

Author

Grime, Gabriel C., Roberto, Marisa, Viana, Ricardo L., Elskens, Yves, Caldas, Iberê L., Instituto de Fisica da Universidade de São Paulo (IFUSP), Universidade de São Paulo = University of São Paulo (USP), Instituto Tecnológico de Aeronáutica [São José dos Campos] (ITA), instituto de fisica, universidade federal do Parana, Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), CNPq, CAPES, FAPESP, COFECUB, and CAPES/COFECUB complex dynamics of plasmas 40273QA- Ph908/18

Subjects
FOS: Mathematics, FOS: Physical sciences, [NLIN]Nonlinear Sciences [physics], Dynamical Systems (math.DS), Mathematics - Dynamical Systems, Chaotic Dynamics (nlin.CD), Nonlinear Sciences - Chaotic Dynamics
Abstract

Nontwist area-preserving maps violate the twist condition along shearless invariant curves, which act as transport barriers in phase space. Recently, some plasma models have presented multiple shearless curves in phase space and these curves can break up independently. In this paper, we describe the different shearless curve breakup scenarios of the so-called biquadratic nontwist map, a recently proposed area-preserving map derived from a plasma model, that captures the essential behavior of systems with multiple shearless curves. Three different scenarios are found and their dependence on the system parameters is analyzed. The results indicate a relation between shearless curve breakup and periodic orbit reconnection-collision sequences. In addition, even after a shearless curve breakup, the remaining curves inhibit global transport., Comment: 12 pages, 7 figures

Published
2023
Full Text
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41. An experimental analysis of regression-obtained HPC scheduling heuristics

Author

de Sousa Rosa, Lucas, Carastan-Santos, Danilo, Goldman, Alfredo, Department of Computer Science (IME-USP), Universidade de São Paulo = University of São Paulo (USP), Data Aware Large Scale Computing (DATAMOVE ), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), and European Project: 956560,REGALE

Subjects
[INFO]Computer Science [cs]
Abstract

Scheduling jobs in High-Performance Computing (HPC) platforms typically involves heuristics consisting of job sorting functions such as First-Come-First-Served or custom (hand-engineered).Linear regression methods are promising for exploiting scheduling data to create simple and transparent heuristics with lesser computational overhead than state-of-the-art learning methods. The drawback is lesser scheduling performance.We experimentally investigated the hypothesis that we could increase the scheduling performance of regression-obtained heuristics by increasing the complexity of the sorting functions and exploiting derivative job features.We used multiple linear regression to develop a factory of scheduling heuristics based on scheduling data. This factory uses general polynomials of the jobs' characteristics as templates for the scheduling heuristics. We defined a set of polynomials with increasing complexity between them, and we used our factory to create scheduling heuristics based on these polynomials. We evaluated the performance of the obtained heuristics with wide-range simulation experiments using real-world traces from 1997 to 2016. Our results show that large-sized polynomials led to unstable scheduling heuristics due to multicollinearity effects in the regression, with small-sized polynomials leading to a stable and efficient scheduling performance. These results conclude that (i) multicollinearity imposes a constraint when one wants to derive new features (i.e., feature engineering) for creating scheduling heuristics with regression, and (ii) regression-obtained scheduling heuristics can be resilient to the long-term evolution of HPC platforms and workloads.

Published
2023

42. Optimal sizing of a globally distributed low carbon cloud federation

Author

Silva Vasconcelos, Miguel, Cordeiro, Daniel, da Costa, Georges, Dufossé, Fanny, Nicod, Jean-Marc, Rehn-Sonigo, Veronika, Universidade de São Paulo = University of São Paulo (USP), Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Système d’exploitation, systèmes répartis, de l’intergiciel à l’architecture (IRIT-SEPIA), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Grant #2021/06867-2, São Paulo Research Foundation (FAPESP), ANR-11-LABX-0025,PERSYVAL-lab,Systemes et Algorithmes Pervasifs au confluent des mondes physique et numérique(2011), ANR-17-EURE-0002,EIPHI,Ingénierie et Innovation par les sciences physiques, les savoir-faire technologiques et l'interdisciplinarité(2017), ANR-19-CE25-0016,DATAZERO2,DATAcenter avec Zero Emission de CO2 : un pas plus loin(2019), and European Project: 956560,REGALE

Subjects
linear program, green computing, energy storage, cloud computing, [SPI.NRJ]Engineering Sciences [physics]/Electric power, follow-the-sun, job scheduling, [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], renewable energy
Abstract

13 p.; The carbon footprint of IT technologies has been a significant concern in recent years. This concern mainly focuses on the electricity consumption of data centers; many cloud suppliers commit to using 100% of renewable energy sources. However, this approach neglects the impact of device manufacturing. We consider in this paper the question of dimensioning the renewable energy sources of a geographically distributed cloud with considering the carbon impact of both the grid electricity consumption in the considered locations and the manufacturing of solar panels and batteries. We design a linear program to optimize cloud dimensioning over one year, considering worldwide locations for data centers, real-life workload traces, and solar irradiation values. Our results show a carbon footprint reduction of about 30% compared to a cloud fully supplied by solar energy and of 85% compared to the 100% grid electricity model.

Published
2023

43. Europium induced point defects in SrSnO3-based perovskites employed as antibacterial agents

Author

Laís Chantelle, Brendan James Kennedy, Cybelle Pereira de Oliveira, Francis Gouttefangeas, Máximo Siu-Li, Richard Landers, Alexandra Ciorita, Arpad Mihai Rostas, Iêda Maria Garcia dos Santos, André Luiz Menezes de Oliveira, Universidade Federal da Paraiba (UFPB), The University of Sydney, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), Universidade Estadual de Campinas = University of Campinas (UNICAMP), National Institute for Research and Development of Isotopic and Molecular Technologies (INCDTIM), 17/2022, 88882.317938/2019-01, PN19 35 02 03, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Financiadora de Estudos e Projetos, FINEP, Ministério da Educação, MEC: 001, 232680/2014-0, and Ministério da Ciência, Tecnologia, Inovações e Comunicações, MCTIC

Subjects
Europium, Mechanics of Materials, Mechanical Engineering, Materials Chemistry, Metals and Alloys, SrSnO3 perovskites, [CHIM]Chemical Sciences, Antibacterial activity, XPS spectroscopy, Photoluminescence, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, EPR spectroscopy
Abstract

International audience; The antibacterial activity of Eu3+-doped SrSnO3-type materials against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) bacteria is described. Two Eu3+-doped SrSnO3 perovskites - (SrEu)SnO3 and Sr(SnEu)O3 - were synthesised by a modified-Pechini method and characterised by XRD, FT-IR, FE-SEM, HR-STEM/EDX, BET, Photoluminescence (PL), UV-Vis, Q-band EPR and XPS to understand the impact of Eu doping on the materials’ properties. Structural characterisations indicated that the desired perovskite phase completely crystallised after calcination at 700 °C. Long and short-range structural changes were observed as a function of the site-doping with Eu and calcination temperature. Small specific surface area, which varied from 8.09 to 13.28 m2/g, was observed for the samples. Nonetheless, the formation of nanoparticles under 10 nm, clusters of nanoparticlesandgt; 100 nm, and nanorods with 100–600 nm × 10–50 nm (length × width) was evidenced. Eu3+ doping led to an increase of Sn2+ and oxygen vacancies in SrSnO3 lattice, playing an essential role in the antibacterial activity. Reduced Eu2+ species were also observed. The samples had activity below 5 % against Escherichia coli, whereas (SrEu)SnO3 displayed an efficiency of 100 % after 24 h against Staphylococcus aureus at a concentration of 1 mg/mL. Our results demonstrate that a specific chemical doping with Eu induces the formation of distinct point defect (Sn2+, Eu2+ and VO•) in the materials, which promoted a negative surface charge that seems to have improved the redox ability and, therefore, enhanced the biocide property.

Published
2023

44. A multiple linear regression approach for understanding the trade-offs in learning HPC job scheduling heuristics

Author

de Sousa Rosa, Lucas, Carastan-Santos, Danilo, Goldman, Alfredo, Department of Computer Science (IME-USP), Universidade de São Paulo = University of São Paulo (USP), Data Aware Large Scale Computing (DATAMOVE ), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), ANR-19-P3IA-0003,MIAI,MIAI @ Grenoble Alpes(2019), and European Project: 956560,REGALE

Subjects
[INFO]Computer Science [cs]
Abstract

Scheduling jobs in High-Performance Computing (HPC) platforms typically involves heuristics consisting of job sorting functions such as First-Come-First-Served or custom (hand-engineered). Linear regression methods are promising for exploiting scheduling data to create simple and transparent heuristics with lesser computational overhead than state-of-the-art learning methods. The drawback is lesser scheduling performance. We experimentally investigated the hypothesis that we can increase the scheduling performance of regression-obtained heuristics by increasing the complexity of the sorting functions. We used multiple linear regression to develop a factory of scheduling heuristics based on scheduling data. This factory uses general polynomials of the jobs' characteristics as templates for the scheduling heuristics. We defined a set of polynomials with increasing complexity between them, and we used our factory to create scheduling heuristics based on these polynomials. We evaluated the performance of the obtained heuristics with simulation experiments considering numerous HPC platform configurations and jobs' characteristics. Our results show that complex polynomials led to unstable scheduling heuristics due to multicollinearity effects in the regression. We also show that a simple linear combination of the jobs' characteristics as a template leads to efficient regression-obtained heuristics. Modifying this linear combination leads to better performances at the price of less transparent heuristics.

Published
2023

45. Search for low-mass dark matter WIMPs with 12 ton-day exposure of DarkSide-50

Author

Agnes, P., Albuquerque, I.F.M., Alexander, T., Alton, A.K., Ave, M., Back, H.O., Batignani, G., Biery, K., Bocci, V., Bonivento, W.M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Campos, M.D., Canci, N., Caravati, M., Cariello, M., Carlini, M., Carpinelli, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., d'Angelo, D., Davini, S., de Candia, A., de Cecco, S., de Filippis, G., de Rosa, G., Derbin, A.V., Devoto, A., d'Incecco, M., Dionisi, C., Dordei, F., Downing, M., d'Urso, D., Fairbairn, M., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G.K., Goretti, A.M., Di Cortona, G. Grilli, Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B.R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hungerford, E.V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C.L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I.N., Mapelli, L.P., Mari, S.M., Maricic, J., Martoff, C.J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V.N., Musico, P., Nozdrina, A.O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Picciau, E., Pocar, A., Poehlmann, D.M., Pordes, S., Poudel, S.S., Pralavorio, P., Price, D.D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A.L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sanford, E., Savarese, C., Schlitzer, B., Semenov, D.A., Shchagin, A., Sheshukov, A., Skorokhvatov, M.D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E.V., Vishneva, A., Vogelaar, R.B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M.M., Xiao, X., Yang, C., Zuzel, G., Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Ave, M., Back, H. O., Batignani, G., Biery, K., Bocci, V., Bonivento, W. M., Bottino, B., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Caminata, A., Canci, N., Caravati, M., Cargioli, N., Cariello, M., Carlini, M., Cataudella, V., Cavalcante, P., Cavuoti, S., Chashin, S., Chepurnov, A., Cicalò, C., Covone, G., D’Angelo, D., Davini, S., De Candia, A., De Cecco, S., De Filippis, G., De Rosa, G., Derbin, A. V., Devoto, A., D’Incecco, M., Dionisi, C., Dordei, F., Downing, M., D’Urso, D., Fiorillo, G., Franco, D., Gabriele, F., Galbiati, C., Ghiano, C., Giganti, C., Giovanetti, G. K., Goretti, A. M., Grilli di Cortona, G., Grobov, A., Gromov, M., Guan, M., Gulino, M., Hackett, B. R., Herner, K., Hessel, T., Hosseini, B., Hubaut, F., Hungerford, E. V., Ianni, An., Ippolito, V., Keeter, K., Kendziora, C. L., Kimura, M., Kochanek, I., Korablev, D., Korga, G., Kubankin, A., Kuss, M., La Commara, M., Lai, M., Li, X., Lissia, M., Longo, G., Lychagina, O., Machulin, I. N., Mapelli, L. P., Mari, S. M., Maricic, J., Messina, A., Milincic, R., Monroe, J., Morrocchi, M., Mougeot, X., Muratova, V. N., Musico, P., Nozdrina, A. O., Oleinik, A., Ortica, F., Pagani, L., Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Pelczar, K., Pelliccia, N., Piacentini, S., Pocar, A., Poehlmann, D. M., Pordes, S., Poudel, S. S., Pralavorio, P., Price, D. D., Ragusa, F., Razeti, M., Razeto, A., Renshaw, A. L., Rescigno, M., Rode, J., Romani, A., Sablone, D., Samoylov, O., Sands, W., Sanfilippo, S., Sandford, E., Savarese, C., Schlitzer, B., Semenov, D. A., Shchagin, A., Sheshukov, A., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stracka, S., Suvorov, Y., Tartaglia, R., Testera, G., Tonazzo, A., Unzhakov, E. V., Vishneva, A., Vogelaar, R. B., Wada, M., Wang, H., Wang, Y., Westerdale, S., Wojcik, M. M., Xiao, X., Yang, C., Zuzel, G., Royal Holloway [University of London] (RHUL), Universidade de São Paulo = University of São Paulo (USP), Pacific Northwest National Laboratory (PNNL), University of South Dakota [Vermillion] (USD), Istituto Nazionale di Fisica Nucleare [Pisa] (INFN), Istituto Nazionale di Fisica Nucleare (INFN), Fermi National Accelerator Laboratory (Fermilab), Istituto Nazionale di Fisica Nucleare [Sezione di Roma 1] (INFN), Istituto Nazionale di Fisica Nucleare, Istituto Nazionale di Fisica Nucleare, Sezione di Cagliari (INFN, Sezione di Cagliari), Università degli studi di Genova = University of Genoa (UniGe), Princeton University, Istituto Nazionale di Fisica Nucleare, Sezione di Genova (INFN, Sezione di Genova), Gran Sasso Science Institute, INFN, University of Naples Federico II = Università degli studi di Napoli Federico II, Virginia Tech [Blacksburg], D.V. Skobeltsyn Institute of Nuclear Physics (SINP), Lomonosov Moscow State University (MSU), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Università degli Studi di Cagliari = University of Cagliari (UniCa), University of Massachusetts System (UMASS), Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Istituto Nazionale di Fisica Nucleare, Sezione di Napoli (INFN, Sezione di Napoli), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), INFN Frascati, Institute of Molecular Genetics of National Research Centre «Kurchatov Institute» [Moscow, Russia], Russian Academy of Sciences [Moscow] (RAS), Institute of High Energy Physics [Beijing] (IHEP), Chinese Academy of Sciences [Changchun Branch] (CAS), Università degli Studi di Enna ' KORE ' = Kore University of Enna, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), University of Houston, Black Hills State University, Nicolaus Copernicus Astronomical Cente (AstroCeNT), Joint Institute for Nuclear Research (JINR), Belgorod National Research University, University of California [Los Angeles] (UCLA), University of California (UC), University of Hawai'i [Hilo], Laboratoire National Henri Becquerel (LNHB), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département d'instrumentation Numérique (DIN (CEA-LIST)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Università degli Studi di Perugia = University of Perugia (UNIPG), Istituto Nazionale di Fisica Nucleare, Sezione di Catania (INFN), Università degli studi di Catania = University of Catania (Unict), INFN Laboratori Nazionali del Gran Sasso, University of Massachusetts [Amherst] (UMass Amherst), University of Manchester [Manchester], Università degli Studi di Milano = University of Milan (UNIMI), Università degli Studi Roma Tre = Roma Tre University (ROMA TRE), Moscow State Engineering Physics Institute (MEPhI), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Nicolaus Copernicus Astronomical Center (AstroCENT), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), SCOAP, DarkSide-50, and HEP, INSPIRE

Subjects
WIMP nucleon: scattering, data analysis method, Cosmology and Nongalactic Astrophysics (astro-ph.CO), dark matter: interaction, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], dark matter interaction, background: model, FOS: Physical sciences, WIMP: mass, WIMP nucleon scattering, spin: dependence, Detector calibration, WIMP: dark matter, spin dependence, argon: target, dark matter, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], detector: calibration, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], cross section: upper limit, instrumentation, detector, mass dependence, Gran Sasso, WIMP mass, radioactivity, argon, [PHYS.ASTR] Physics [physics]/Astrophysics [astro-ph], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], experimental results, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We report on the search for dark matter WIMPs in the mass range below 10 GeV/c$^2$, from the analysis of the entire dataset acquired with a low-radioactivity argon target by the DarkSide-50 experiment at LNGS. The new analysis benefits from more accurate calibration of the detector response, improved background model, and better determination of systematic uncertainties, allowing us to accurately model the background rate and spectra down to 0.06 keV$_{er}$. A 90% C.L. exclusion limit for the spin-independent cross section of 3 GeV/c$^2$ mass WIMP on nucleons is set at 6$\times$10$^{-43}$ cm$^2$, about a factor 10 better than the previous DarkSide-50 limit. This analysis extends the exclusion region for spin-independent dark matter interactions below the current experimental constraints in the $[1.2, 3.6]$ GeV/c$^2$ WIMP mass range., 11 pages, 12 figures

Published
2023

46. COVID-19-Associated Pulmonary Aspergillosis Isolates Are Genomically Diverse but Similar to Each Other in Their Responses to Infection-Relevant Stresses

Author

Mead, Matthew E., de Castro, Patricia Alves L., Steenwyk, Jacob L., Gangneux, Jean-Pierre, Hoenigl, Martin, Prattes, Juergen, Rautemaa‐richardson, Riina, Guegan, H, Moore, C, Lass-Floerl, Cornelia, Reizine, Florian, Valero, Clara, van Rhijn, Norman J., Bromley, Michael J, Rokas, Antonis H., Goldman, Gustavo H., Gago, Sara, Vanderbilt University [Nashville], Universidade de São Paulo = University of São Paulo (USP), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Hôpital Sud [CHU Rennes], CHU Pontchaillou [Rennes], Medical University Graz, University of Manchester [Manchester], Leopold Franzens Universität Innsbruck - University of Innsbruck, Howard Hughes Medical Institute through the James H. Gilliam Fellowships for Advanced Study program, National Science Foundation [DEB-2110404], National Institutes of Health/National Institute of Allergy and Infectious Diseases [R56 AI146096, R01 AI153356], Burroughs Wellcome Fund, NIHR Manchester Biomedical Research Centre, Fungal Infection Trust, Manchester Academy of Health Sciences, Dowager Countess Eleanor Peel Trust, Wellcome Trust [219551/Z/19/], Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) from Brazil [2021/04977-5, BEPE 2020/01131-5], Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) from Brazil [301058/2019-9, 404735/2018-5, 163550/2020-4], and National Institutes of Health/National Institute of Allergy and Infectious Diseases grant [R01AI153356]

Subjects
strain heterogeneity, SARS-CoV-2, Aspergillus fumigatus, [SDV]Life Sciences [q-bio], fungal pathogen, coinfection
Abstract

International audience; Secondary infections caused by the pulmonary fungal pathogen Aspergillus fumigatus are a significant cause of mortality in patients with severe coronavirus disease 19 (COVID-19). Even though epithelial cell damage and aberrant cytokine responses have been linked to susceptibility to COVID-19-associated pulmonary aspergillosis (CAPA), little is known about the mechanisms underpinning copathogenicity. Here, we analyzed the genomes of 11 A. fumigatus isolates from patients with CAPA in three centers from different European countries. CAPA isolates did not cluster based on geographic origin in a genome-scale phylogeny of representative A. fumigatus isolates. Phenotypically, CAPA isolates were more similar to the A. fumigatus A1160 reference strain than to the Af293 strain when grown in infection-relevant stresses, except for interactions with human immune cells wherein macrophage responses were similar to those induced by the Af293 reference strain. Collectively, our data indicate that CAPA isolates are genomically diverse but are more similar to each other in their responses to infection-relevant stresses. A larger number of isolates from CAPA patients should be studied to better understand the molecular epidemiology of CAPA and to identify genetic drivers of copathogenicity and antifungal resistance in patients with COVID-19. IMPORTANCE Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) has been globally reported as a life-threatening complication in some patients with severe COVID-19. Most of these infections are caused by the environmental mold Aspergillus fumigatus, which ranks third in the fungal pathogen priority list of the WHO. However, little is known about the molecular epidemiology of Aspergillus fumigatus CAPA strains. Here, we analyzed the genomes of 11 A. fumigatus isolates from patients with CAPA in three centers from different European countries, and carried out phenotypic analyses with a view to understanding the pathophysiology of the disease. Our data indicate that A. fumigatus CAPA isolates are genomically diverse but are more similar to each other in their responses to infection-relevant stresses.

Published
2023

47. Species diversity and systematics of the Leptodactylus melanonotus group (Anura, Leptodactylidae): review of diagnostic traits and a new species from the Eastern Guiana Shield

Author

Thiago R. Carvalho, Antoine Fouquet, Mariana L. Lyra, Ariovaldo A. Giaretta, C. Eduardo Costa-Campos, Miguel T. Rodrigues, Célio F. B. Haddad, Santiago R. Ron, Aquaculture Center of São Paulo State University (CAUNESP), Evolution et Diversité Biologique (EDB), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Universidade Federal de Uberlândia - UFU, Universidade do Estado do Amapá (UEAP), Universidade de São Paulo = University of São Paulo (USP), Université pontificale catholique d'Équateur / Pontificia Universidad Católica del Ecuador) (PUCE), São Paulo Research Foundation in Brazil (Fundação de Amparo à Pesquisa do Estado de São Paulo [FAPESP] processes #2003/10335-8, #2011/50146-6, #2012/15763-7, #2013/50741-7, #2017/08489-0, # 2018/03428-5, and #2018/17118-8), National Council for Scientific and Technological Development (Fundação de Amparo à Pesquisa do Estado de São Paulo [CNPq] grant #446935/2014-0 to AAG, 301778/2015-9 to MTR, and #306623/2018-8 to CFBH, postdoctoral fellowship #163918/2020-1 to TRC), Brazilian government (ICMBio/SISBIO #30059), ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010), and ANR-11-IDEX-0002,UNITI,Université Fédérale de Toulouse(2011)

Subjects
Leptodactylinae, Neotropics, advertisement calls, Amazonia, [SDV]Life Sciences [q-bio], calling habitat, Plant Science, phylogeny, Ecology, Evolution, Behavior and Systematics, integrative taxonomy, biodiversity
Abstract

Supplemental material for this article can be accessed here: http://dx.doi.org/10.1080/14772000.2022.2089269.; International audience; The Leptodactylus melanonotus species group is an anuran clade widely distributed in the Neotropics. This clade harbours many species that are difficult to identify because of incomplete taxonomic knowledge, ambiguous species boundaries and distribution. Here we expand the understanding of species diversity of this Leptodactylus clade by analysing mtDNA sequences for over 600 individuals, delimiting Operational Taxonomic Units (OTUs), and updating species identifications and distributions by linking sequences to morphotypes and calls. Also, we review the morphological and acoustic traits traditionally used as diagnostic characters of species within this group. The DNA-based species delimitation analyses yielded 57 OTUs. Given that only 19 taxa are currently recognized as valid species, our results suggest the existence of many unnamed species within the L. melanonotus group. After reassessing morphological traits in the group, we concluded that the combined use of dorsolateral fold, upper lip stripe, and belly colouration is sufficiently informative for species identification in most cases, especially when associated with data on geographic distribution and habitat use. Regarding advertisement calls, the patterns of amplitude and frequency modulation, calling rate, and dominant frequency were also informative for species discrimination. Furthermore, we designate a neotype for L. wagneri, for which we also describe the advertisement call, and make comparisons with congeners of the L. melanonotus group, especially with the partially sympatric L. leptodactyloides. Lastly, we name and describe a new species endemic to the Eastern Guiana Shield. Patterns of distribution and habitat use in the L. melanonotus group revealed that sympatric occurrences are more commonly found among distantly related species, whereas allopatric occurrences correspond to closely related ones. Speciation between closely related species of the group seems to be related to ecological divergence (open vs. forest habitats) in parallel with clear morphological and acoustic differentiation.

Published
2022

48. Search for $^{22}$Na in novae supported by a novel method for measuring femtosecond nuclear lifetimes

Author

Chloé Fougères, Francois de Oliveira Santos, Jordi Jose, Caterina Michelagnoli, Emmanuel Clément, Yung Hee Kim, Antoine Lemasson, Valdir Guimaraes, Diego Barrientos, Daniel Bemmerer, Giovanna Benzoni, Andrew Boston, Roman Bottger, Florent Boulay, Angela Bracco, Igor Celikovic, Bo Cederwall, Michal Ciemala, Clement Delafosse, Cesar Domingo-Pardo, Jeremie Dudouet, Jurgen Eberth, Zsolt Fulop, Vicente Gonzalez, Johan Goupil, Herbert Hess, Andrea Jungclaus, Ayse Kaşkaş, Amel Korichi, Silvia Lenzi, Silvia Leoni, Hongjie Li, Joa Ljungvall, Araceli Lopez-Martens, Roberto Menegazzo, Daniele Mengoni, Benedicte Million, Jaromir Mrazek, Daniel Napoli, Alahari Navin, Johan Nyberg, Zsolt Podolyak, Alberto Pullia, Begona Quintana, Damien Ralet, Nadine Redon, Peter Reiter, Kseniia Rezynkina, Frédéric Saillant, Marie-Delphine Salsac, Angel Sánchez-Benítez, Enrique Sanchis, Menekse Senyigit, Marco Siciliano, Nadezda Smirnova, Dorottya Sohler, mihai stanoiu, Christophe Theisen, Jose Javier Valiente-Dobon, Predrag Ujic, Madalena Zielinska, Argonne National Laboratory [Lemont] (ANL), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de Catalunya [Barcelona] (UPC), Institut Laue-Langevin (ILL), Institute for Basic Science [Daejeon] (IBS), Instituto de Fisica da Universidade de São Paulo (IFUSP), Universidade de São Paulo = University of São Paulo (USP), CERN [Genève], Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Istituto Nazionale di Fisica Nucleare (INFN), University of Liverpool, Vinca Institute of Nuclear Sciences, University of Belgrade (VINCA), Department of Physics, Royal Institute of Technology (KTH), Institute of Nuclear Physics PAN, Krakow, Poland, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Universidad de Valencia, Universitat de València (UV), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut für Kernphysik der Universität zu Köln, Universität zu Köln = University of Cologne, Institute for Nuclear Research [Budapest] (ATOMKI), Hungarian Academy of Sciences (MTA), Instituto de Estructura de la Materia, CSIC, E-28006 Madrid, Physics Department, Ankara University, Ankara University, Istituto Nazionale di Fisica Nucleare, Sezione di Padova (INFN, Sezione di Padova), Università degli Studi di Padova = University of Padua (Unipd), Dipartimento di Fisica, Università degli studi di Milano, Istituto Nazionale di Fisica Nucleare (INFN)-Università degli Studi di Milano = University of Milan (UNIMI), Nuclear Physics Institute of the Czech Academy of Sciences, INFN, Laboratori Nazionali di Legnaro, Department of Physics and Astronomy, Uppsala University, Uppsala University, Department of Physics, University of Surrey, University of Surrey (UNIS), Universidad de Salamanca, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CEAFMC, University of Huelva, Laboratoire de Physique des Deux Infinis Bordeaux (LP2I - Bordeaux), Université de Bordeaux (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, IFIN-HH Bucharest, ANR-17-CE31-0026,OASIS,Optimisation d'Agata pour la physique(2017), and European Project: 212692,EC:FP7:INFRA,FP7-INFRASTRUCTURES-2007-1,SPIRAL2PP(2007)

Subjects
High Energy Astrophysical Phenomena (astro-ph.HE), astro-ph.HE, [PHYS]Physics [physics], Astrophysics and Astronomy, astro-ph.SR, Astrophysics - Solar and Stellar Astrophysics, FOS: Physical sciences, Nuclear Physics - Experiment, Nuclear Experiment (nucl-ex), nucl-ex, Astrophysics - High Energy Astrophysical Phenomena, Nuclear Experiment, Solar and Stellar Astrophysics (astro-ph.SR)
Abstract

Classical novae are thermonuclear explosions in stellar binary systems, and important sources of $^{26}$Al and $^{22}$Na. While gamma rays from the decay of the former radioisotope have been observed throughout the Galaxy, $^{22}$Na remains untraceable. The half-life of $^{22}$Na (2.6 yr) would allow the observation of its 1.275 MeV gamma-ray line from a cosmic source. However, the prediction of such an observation requires good knowledge of the nuclear reactions involved in the production and destruction of this nucleus. The $^{22}$Na($p,\gamma$)$^{23}$Mg reaction remains the only source of large uncertainty about the amount of $^{22}$Na ejected. Its rate is dominated by a single resonance on the short-lived state at 7785.0(7) keV in $^{23}$Mg. In the present work, a combined analysis of particle-particle correlations and velocity-difference profiles is proposed to measure femtosecond nuclear lifetimes. The application of this novel method to the study of the $^{23}$Mg states, combining magnetic and highly-segmented tracking gamma-ray spectrometers, places strong limits on the amount of $^{22}$Na produced in novae, explains its non-observation to date in gamma rays (flux < 2.5x$10^{-4}$ ph/(cm$^2$s)), and constrains its detectability with future space-borne observatories., Comment: 18 pages, 3 figures, 1 table

Published
2022

49. Open book structures on semi-algebraic manifolds

Author

Antonio Andrade do Espirito Santo, Ying Chen, R. Araújo Dos Santos, Nicolas Dutertre, Institut de Mathématiques de Marseille (I2M), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Laboratoire Angevin de Recherche en Mathématiques (LAREMA), Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS), Instituto de Ciências Mathemàticas e de Computação [São Carlos] (ICMC-USP), Universidade de São Paulo (USP), Instituto de Ciencias Matematicas e de Computaçao, Universidade de São Paulo (USP)-Universidade de São Paulo (USP), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), and Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP)

Subjects
semi-algebraic manifolds, General Mathematics, Dimension (graph theory), real Milnor fibrations, Algebraic geometry, 01 natural sciences, symbols.namesake, Mathematics - Algebraic Geometry, Euler characteristic, [MATH.MATH-GT]Mathematics [math]/Geometric Topology [math.GT], FOS: Mathematics, 0101 mathematics, Algebraic Geometry (math.AG), Mathematics, Mathematics - General Topology, Discrete mathematics, Homotopy, 14P10, 32S55, 58K15, 58K65, 010102 general mathematics, General Topology (math.GN), Fibration, Manifold, 010101 applied mathematics, TOPOLOGIA ALGÉBRICA, Projection (relational algebra), Number theory, symbols, [MATH.MATH-AG]Mathematics [math]/Algebraic Geometry [math.AG], open book structure
Abstract

International audience; Given a $C^2$ semi-algebraic mapping $F: \mathbb{R}^N \rightarrow \mathbb{R}^p,$ we consider its restriction to $W\hookrightarrow \mathbb{R^{N}}$ an embedded closed semi-algebraic manifold of dimension $n-1\geq p\geq 2$ and introduce sufficient conditions for the existence of a fibration structure (generalized open book structure) induced by the projection $\frac{F}{\Vert F \Vert}:W\setminus F^{-1}(0)\to S^{p-1}$. Moreover, we show that the well known local and global Milnor fibrations, in the real and complex settings, follow as a byproduct by considering $W$ as spheres of small and big radii, respectively. Furthermore, we consider the composition mapping of $F$ with the canonical projection $\pi: \mathbb{R}^{p} \to \mathbb{R}^{p-1}$ and prove that the fibers of $\frac{F}{\Vert F \Vert}$ and $\frac{\pi\circ F}{\Vert \pi\circ F \Vert}$ are homotopy equivalent. We also show several formulae relating the Euler characteristics of the fiber of the projection $\frac{F}{\Vert F \Vert}$ and $W\cap F^{-1}(0).$ Similar formulae are proved for mappings obtained after composition of $F$ with canonical projections.

Published
2014

50. Isotopic and geochemical identification of main groundwater supply sources to an alluvial aquifer, the Allier River valley (France)

Author

Mohammed, Nabaz, Celle-Jeanton, Hélène, Huneau, Frederic, Le Coustumer, Philippe, Lavastre, V., Bertrand, G, Charrier, Gaspard, Clauzet, M.L., Laboratoire Magmas et Volcans (LMV), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Sciences pour l'environnement (SPE), Université Pascal Paoli (UPP)-Centre National de la Recherche Scientifique (CNRS), ENGESID, Université de Bordeaux (UB), Instituto de Geosciências, Centro de Pesquisas de Água Subterrânea, Polytechnic School [São Paulo], Universidade de São Paulo = University of São Paulo (USP)-Universidade de São Paulo = University of São Paulo (USP), Laboratoire de Géographie Physique et Environnementale (GEOLAB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut national des sciences de l'Univers (INSU - CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Pascal Paoli (UPP), University of São Paulo (USP)-University of São Paulo (USP), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne (UCA)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Hydrochemistry, [SDE.MCG]Environmental Sciences/Global Changes, Alluvial aquifer, Allier River, [SDU.STU.HY]Sciences of the Universe [physics]/Earth Sciences/Hydrology, Groundwater, Stable isotopes
Abstract

International audience; Hydrodynamic, hydrochemical, and isotopic investigations were carried out on 18 points, including boreholes, piezometers, and surface waters, from February 2011 to August 2012, to assess groundwater quality in the unconfined shallow alluvial aquifer of the Allier River (one of the main tributary of the Loire River). The study area, located near the city of Clermont-Ferrand (France), plays an important socio-economic role as the alluvial aquifer is the major source of drinking water for about 100,000 inhabitants. The objective of the project aims at understanding the functioning of alluvial aquifers that occupy a pre-eminent position in the hydrogeologic landscape both for their economic role - production of drinking water and agricultural development - and for their ecological role. Moreover, this study also targets at determining the factors and processes controlling shallow groundwater quality and origin. The water circulates from the south, with a natural alimentation from the hills in the non-pumped part of the alluvial aquifer. In the pumping zone, this general behaviour is altered by the pumping that makes the water from the Allier River enter the system in a large proportion. Four end-members have been identified for the recharge of the alluvial groundwater: rainfall, Allier River, surrounding hills' aquifer and the southern non-pumped part of the alluvial system. Results indicate that, despite the global Ca-HCO3 water type of the groundwater, spatial variations of physico-chemical parameters do exist in the study area. Ionic concentrations increase from the Allier River towards east due either to the increase in the residence time or a mixing with groundwater coming from the aquifer's borders. Stable isotopes of the water molecule show the same results: boreholes close to the river bank are recharged by the Allier River (depleted values), while boreholes far from the river exhibit isotopic contents close to the values of hills' spring or to the southern part of the alluvial aquifer, both recharged by local precipitation. One borehole (B65) does not follow this scheme of functioning and presents values attesting of a probable sealing of the Allier River banks. Based on these results, the contribution of each end-member has been calculated and the functioning of the alluvial system determined.

Published
2014

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