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1. Information Technology: A Model for Brandon University.

Author

Brandon Univ. (Manitoba). and Bazillion, Richard J.

Abstract

Information technology is having a profound effect on higher education in North America, and Brandon University in Manitoba (Canada) is in a position to join this movement in its early stages. The case for integrating information technology into the curriculum is argued, and the potential role of the new library complex in the teaching function is outlined. The recent expansion of the campus information network, MONET, has enhanced opportunities for faculty members, but this technology has yet to be extended to students. The new library is planned to allow the incorporation of information technology into the curriculum, should the university and the community elect to move students into the information technology age. Practical suggestions are offered to accomplish this. A first step is to begin developing courses that apply information technology to the specific research assignments required of students. A second, longer-range task is to create new courses on the history, sociology, and psychology of the information society, so that students gain an intellectual context in which to place contemporary events. It will also be essential to ensure that the technological infrastructure of the campus does not become progressively obsolete because of financial constraints. An appendix provides an annotated bibliography that lists 45 sources of additional information. (Contains 42 references.) (SLD)

Published
1993

2. Diversity and Excellence in Education: An Integrated Approach to Improving Accessibility at the University of Winnipeg. The Final Report of the President's Task Force on Student Accessibility at The University of Winnipeg.

Author

Winnipeg Univ. (Manitoba).

Abstract

This report presents the results of a study conducted by the University of Winnipeg, Manitoba, Canada to review the university's policies towards those groups within Canadian society which have low participation rates in post-secondary education. Following the introduction, the section, "Accessibility and the University of Winnipeg," evaluates some recent developments in academic accessibility programming at the university. The section, "University Life and Culture," explains the importance of the relationship between what the school identifies as the culture of the university and accessibility. Student services are the focus of "Options for Improving Student Services." The section "Curriculum, Teaching, and Scholarship: Statement of Objectives" identifies the values and attitudes that shaped the recommendations in the areas of teaching, curriculum, and research. Next, "Proposals on Curriculum," focuses on student retention, particularly in the first year. In "General Curriculum Revisions and Accessibility," the university is urged to initiate a comprehensive development of its curriculum regarding matters of gender, race, ethnicity, class, and disability. "Promotion of the Value of Teaching" presents the recommendation that faculty members be encouraged to explore new pedagogical assumptions and approaches that will improve the classroom experience for students and faculty. Finally, the section "Coordinating and Evaluating Accessibility Initiatives," concludes the report with a statement for the need to ensure the effective coordination and evaluation of accessibility initiatives over the coming years. An appendix and summary of recommendations are included. (GLR)

Published
1990

3. Small Universities' Response to International Development. Proceedings of the International Education and Small Universities' Conference/Workshop (Brandon, Manitoba, Canada, March 20-22, 1990).

Author

Brandon Univ. (Manitoba). International Development Projects Office., Halamandaris, P. G., and Serfaty, Meir

Abstract

This proceedings provides summaries of the group discussions and presentations of a conference/workshop convened in March 1992 to share information concerning the future planning of educational partnerships between developing countries and Canada's small universities. The approaches examined at the conference are characterized by more sensitivity and respect for local conditions, cultures and policies, expressed through a sharing of power and decision making in the planning, execution, and evaluation of projects. The workshops and presentations presented point to the need for international projects to be driven by the needs of the countries hosting them. In addition, workshops examined international projects from the perspective of the sponsoring agencies involved, the initiation and maintenance of these projects, and the experiences of international students from the perspective of the student liaison officers and advisors. The final session considered the future and makes some projections for small universities and international education. The appendix contains a list of the conference participants and the conference agenda. (GLR)

Published
1990

4. Indian Metis Project for Careers in Teacher Education (I.M.P.A.C.T.E.). An Internal Evaluation.

Author

Brandon Univ. (Manitoba). and Loughton, A. John

Abstract

Individual profiles (age, sex, marital status, number of dependents, type of withdrawal, academic success, center attended, educational background, and date of enrollment) were established for 87% of the 138 students enrolled in the Indian Metis Project for Careers in Teacher Education (IMPACTE) at Brandon University (Canada) between 1970 and 1974. Soliciting attitudes and opinions re: project format, courses, field experience, communication, role of the project personnel, and general project effectiveness, questionnaires were given to cooperating teachers, current students, graduates, and instructional staff. Personal interviews were also employed in the evaluation of IMPACTE. Some results were: almost 50% of the 1971 student recruits will graduate with teaching certificates; human service support for students should be increased; cooperating teachers, students, and graduates wanted a more vigorous approach to irresponsible student behavior; students wanted course instructors to spend 2 to 3 days a week in the rural centers and they very much wanted to help in the selection of courses; cooperating teachers wanted better, more systematic communication with the University and its faculty; students wanted methods instructors in their classes, faculty advisor visits weekly, a part in the decision making process, and more and better preparation for more extended field experiences. (JC)

Published
1974

5. Television and the Canadian Indian: Impact and Meaning among Algonkians of Central Canada.

Author

Winnipeg Univ. (Manitoba)., Granzberg, Gary, and Steinbring, Jack

Abstract

This study is a controlled longitudinal analysis of the impact and meaning of television among Algonkian Indians of central Canada which incorporates eight years of extensive participant observation field work and objective social and psychological testing in the pre- and post-television periods. The impact of television is discussed in terms of stress and modernization, and it is argued that positive and negative television inputs in these areas are heavily conditioned by meanings derived from analogies between television and certain cultural traditions, which promoted exaggerated copying, identification, and trust in TV characters on the part of naive viewers. A report of the ethnographic findings resulting from long term field work in three Algonkian communities reviews the impact and meaning of television in these communities as revealed in field observations and interviews. Findings based on psychological and sociological tests, economic sales records, video tape experimentation, and questionnaire opinion surveys are also reported, and the final section provides a review of the work and its implications, clarifying some of the issues in telecommunication policy for developing areas and making some recommendations. A study of the relationship between music associated with a TV show and its appeal to an Ojibwa audience is appended. (CHC)

Published
1980

6. BUNTEP: The Profile of a Teacher Education Project.

Author

Brandon Univ. (Manitoba)., Robertson, D. A., and Loughton, A. J.

Abstract

Describing and evaluating the development of the Brandon University Northern Teacher Education Project (BUNTEP) in Manitoba, Canada, this document presents the following sections: (1) Historical Overview; (2) Project Implementation Strategy (emphasis upon coordination with past projects); (3) The Students (the average BUNTEP student is probably female, approximately 23 years old, educated to grade 10, responsible for 2 dependents, characterized by an intermitent work history, and a Canada Native living in a rural community north of the fifty-third parallel); (4) Visiting Professors (use of facilities, time, and personnel is reported to be less than adequate); (5) School Personnel (surveys reveal a generally positive attitude on the part of school personnel); (6) Participating Communities (9 students from Nelson House, 8 from Cross Lake, 15 from Island Lake, 12 from the Pas, 9 from Pequis, 14 from Split Lake, and 11 from Camperville); (7) The Program (a 3-year program offering teacher certification after the first 2 years and providing flexibility in that 36 of the first 60 credit hours can be electives wherein only 6 of the 36 hours must be education electives); (8) Organization (emphasis on administrative support for the off-campus centers and center coordinators, Native cultural awareness in both curriculum and personnel, and student participation in BUNTEP development); (9) Recommendations (8 specific recommendations); (10) Appendices. (JC)

Published
1976

7. A Rural-Urban Comparison of the Knowledge and Implementation of WHMIS Safety Regulations by Manitoba Science Teachers. Rural Education Research Series No. 5.

Author

Brandon Univ. (Manitoba). Rural Development Inst. and Rice, Barbara Ellen

Abstract

In October 1988, the Workplace Hazardous Materials Information System (WHMIS) became law in Canada and was applied to school classrooms and laboratories. Educators expressed concerns that difficulties in implementation would negatively affect student laboratory activity. In 1994, a survey of 219 randomly selected Manitoba junior and senior high school science teachers (128 rural and 91 urban) examined issues related to implementation and effects of WHMIS regulations. Results show that while WHMIS knowledge and implementation were generally low, rural teachers scored significantly lower than urban teachers. Both rural and urban teachers scored higher on items that were part of their safety routines before WHMIS regulations. Urban and rural teachers reported few accidents, and accidents were not a result of noncompliance with WHMIS. WHMIS inspections were related positively to higher knowledge and implementation categories. Higher WHMIS knowledge and implementation scores were associated with the following teacher characteristics: more experience in subjects and grade levels currently assigned, teaching grades 11-12, more university science courses, more science methods and curriculum courses, and access to a laboratory assistant. Compared to rural teachers, urban teachers had a significant advantage in most of these areas. High percentages of both rural and urban teachers met or exceeded the number of science activities recommended by grade 11-12 provincial guides. The effect of WHMIS implementation on student laboratory activity was inconclusive. Contains 33 references. (Author/SV)

Published
1996

8. Child Care and Child Safety for Farm Children in Manitoba. RDI Report Series 1994-7.

Author

Brandon Univ. (Manitoba). Rural Development Inst. and Brockman, Lois M.

Abstract

A Manitoba survey examined child care use, child safety concerns, and parents' on-farm and off-farm work to determine the needs of farm families for child care services. Of 972 questionnaires mailed to Manitoba farm residences, 121 were returned by respondents who were actively farming and living on a farm with at least one child younger than 16 years. Most husbands and wives were full-time farmers; 19 percent of husbands and 35 percent of wives were regularly employed off the farm. Farm help was hired by 55 percent of respondents, mostly on a seasonal basis. Responding families included 294 children under age 16 (76 percent under 13). Child care was used regularly by 21 percent of families and was used during peak farm times (such as seeding or harvest time) by 55 percent. Child care was provided mostly by relatives, followed by older siblings and nonrelatives, but was never provided by a day care center. Alternatives to child care for 64 percent of farm families were to take the children along or to leave them alone while parents worked on the farm. In general, the greatest concerns for children's safety on farms related to augers, power take-off equipment, farm chemicals, and large machinery. Safety concerns varied with the number of hours parents worked on the farm and children's ages. Parents indicated the youngest age at which children could participate in various farm activities. Child care support preferred by farm families was either a caregiver in the farm home or hired farm help to free the wife for child care. Recommendations outline a model for rural child care services. Appendices elaborate on the model and include the survey questionnaire. (Author/SV)

Published
1994

9. A Preceptorship Model for Nurses in Rural Health Care Facilities. Rural Education Research Series No. 2.

Author

Brandon Univ. (Manitoba). Rural Development Inst. and Pottinger, M. Enid

Abstract

This report describes a preceptorship model that provides student nurses with clinical practice in rural health facilities. The development and implementation of a preceptorship model reflects a partnership between nursing education and nursing service--between the urban nursing school and the rural hospital. A five-stage preceptorship model is presented that includes development of guidelines, selection of participants, orientation of participants, implementation, and evaluation. The model draws on a literature review plus feedback from nurse preceptors and graduating nursing students. The model emphasizes the importance of clearly stated purposes and objectives; guidelines outlining the roles and responsibilities of the student, the preceptor, and the faculty liaison; and careful selection and preparation of all participants. In spring 1992, 24 students completed their senior practicums in rural hospitals using the preceptorship model; all were satisfied with the experience, met their clinical objectives, and completed their learning contracts. Evaluations of the model by the faculty liaison person, preceptors, and students resulted in 18 recommendations to improve implementation of the model. The strongest preceptor recommendation was that students and preceptors work identical hours with identical patient assignments. Contains 53 references. Appendices include preceptor questionnaire, terminal nursing competencies, agreement between nursing school and health care facility, form for assessing potential preceptors, and evaluation forms for students and preceptors. (Author/SV)

Published
1994

10. Teaching Art by Teleconferencing in Rural Schools. Rural Education Research Series No. 4.

Author

Brandon Univ. (Manitoba). Rural Development Inst. and Bewer, Mary Judith

Abstract

An art course was adapted from the Manitoba curriculum for grade 9 and delivered via teleconferencing to three small, geographically isolated schools in Birdtail River School Division, Manitoba. Participants included 1 adult planning to study art at a community college and 38 students in grades 8-10 at a German-speaking Hutterian K-10 school, a French-speaking K-11 school, and an English-speaking college preparatory school. The course was based on previous experience with an experimental teleconference art course, a review of practices of teaching art by distance education, and consultation with 11 Manitoba teachers who had taught other subjects via teleconferencing. Course design involved writing workbook modules that could also be completed via independent study, selection of texts and art reproduction kits for purchase by participating schools, preparation of supplementary visual displays, and planning of strategies to increase interactions between teacher and students and among students from different sites. Implementation steps included preliminary visits to each site for classroom preparation and orientation of students and class proctors, preparation of detailed proctor guides, meetings with principals to gain their support, and arrangements to transport student art assignments. Course evaluations by the teacher, students, and proctors indicated that teleconferencing, while no one's method of choice, was a viable delivery method producing results similar to those in regular classrooms. Recommendations relate to the status of teleconference courses in schools, provision of quality resources, and the search for appropriate models for teleconference courses. Contains 31 references. Appendices include evaluation questionnaires and course materials. (SV)

Published
1994

11. Strategies for Restructuring Manitoba Secondary Schools. Rural Education Research Series No. 3.

Author

Brandon Univ. (Manitoba). Rural Development Inst. and Britton, Stephen C.

Abstract

Manitoba's secondary school system is under increasing pressure to respond to economic and social changes transforming the province. This report explores existing strategies related to curriculum development and adaptation, instruction, assessment, and leadership that could be used to restructure Manitoba secondary schools. A literature review examines the meaning of restructuring; restructuring rationale; history of high school reform; restructuring strategies for curriculum, instruction, assessment, and leadership; and special concerns of small rural secondary schools. Also reviewed are the structure and goals of secondary education in Manitoba, as well as current practices in curriculum, instruction, assessment, and leadership. Fifteen secondary schools in British Columbia, Manitoba, Ontario, and Alberta were identified as conducting restructuring experiments. Qualitative case studies revealed that 11 of the schools used one or more of the following strategies: (1) restructured curriculum (curriculum adaptation to achieve magnet school status, curriculum negotiation between teachers and students, interdisciplinary curriculum); (2) restructured instruction (independent learning, project-centered learning, authentic learning based on a production process); (3) restructured student evaluation (performance assessment, alternative assessment); and (4) restructured leadership roles (transformational leadership, strategic planning). Ways that rural Manitoba secondary schools could implement such strategies are suggested. Contains 81 references. (SV)

Published
1994

12. A Descriptive Analysis of Diagnostic Services for Special Needs Students in Agro-Manitoba. Rural Education Research Series No. 1.

Author

Brandon Univ. (Manitoba). Rural Development Inst. and Bradshaw, Robin

Abstract

With widespread implementation of mainstreaming in Manitoba, regular classroom teachers need diagnostic information to plan modified programs for special needs students. This report describes the demand for and availability of diagnostic services for special needs students in Agro-Manitoba, which comprises 34 rural school divisions in the province's agricultural area. A literature review examines use of formal versus informal assessment, stages in the referral process, and recent developments in reading diagnosis. A survey was developed and mailed to all special education administrators in Agro-Manitoba. Responses were received from 26 of the 34 school divisions. The survey covered the availability of various clinical services, consultant services, and community services that provide diagnostic information; sharing of services with other school divisions; new programs or practices to improve services; the location of services; details of the referral process; types of problems referred to the province's Diagnostic Support Centre (DSC), DSC services to districts, and related costs; and suggested changes. Interviews were also carried out at the DSC and at the Child Care and Development Branch of the provincial department of education. Results indicate that many rural divisions are sharing services; large caseloads and long waits for services are problems; and some school divisions need increased school support staff. Recommendations are offered based on survey results and comparisons with expert opinions on essential services. Appendices include the survey questionnaire, interview schedules, and a glossary. Contains 36 references, and 9 tables of data. (SV)

Published
1993

13. Final Report on the Pilot of the Junior High Science Program 'The Natural World' at Vincent Massey School, Brandon, Manitoba, Canada, July 1977.

Author

Brandon Univ. (Manitoba). and Neufeld, Gerald G.

Abstract

This report presents the results of a comparative study of two junior high school science programs, a modular, individualized program The Natural World (TNW) and the more traditional Exploring Science program. Opinionnaires were used to sample grade 7 and 8 students' perceptions of their science course and attitudes toward it at several times during the school year. The study indicated that the students using the TNW program had more positive attitudes toward their science program than the other group of grade 7 students while there appeared to be little difference in attitudes between the two groups of grade 8 students. (Author/MA)

Published
1977

14. Proceedings of the Local Histories Workshops (Brandon, Manitoba, November 23, 1977 and April 26, 1978).

Author

Brandon Univ. (Manitoba). and Cunningham, Sally

Abstract

In recent years many Canadian groups have recognized their communities' centennials by undertaking the task of compiling and recording local history. Responding to numerous questions on producing local history books, the Centre staged two workshops to provide amateur historians with the kinds of information they need for such projects. Sessions at the workshops were devoted to five areas: (1) researching, (2) compiling and writing, (3) funding, (4) printing, and (5) distributing. For the research session a panel of speakers discussed such areas as the need for positive attitudes on the part of the researcher, the necessity of scheduling work time, potential local sources of information, and types of materials at the Manitoba Provincial Archives Collection. The sessions devoted to writing and compiling featured five speakers who discussed such topics as format; the need to include such information as maps, photographs, indexes and bibliographies; style; logical organization of a history; and the desirability of a unified, coherent story. One speaker suggested that a series of newspaper articles or slide or videotape shows might be preferable alternatives to a book. Sources of grants were provided in the session on funding, and the printing session speaker outlined eight steps toward a successful community history book. The final session was devoted to pricing, promoting, distributing and selling the finished product. (DS)

Published
1978

15. Year Three Annual Report of the Rural Community Resource Centre. October 1, 1977 to September 30, 1978.

Author

Brandon Univ. (Manitoba).

Abstract

In many ways the 1977-78 third year of operation of the Rural Community Resource Centre (Brandon, Manitoba) closely reflected the stresses and dynamics of the society in which it exists. Fiscal uncertainty resulted in critical analysis of the objectives and operations of the Centre and increased accountability for government granted funds. The Northern Advisory Committee was formed to focus specifically on regional issues. The Centre was involved in some 45 projects, 28 of which were initiated during the past year, in the areas of information and research, community and organizational consultation, and leadership education. The Rural Archives, housed at Brandon University, continued to collect documents tracing the activity, growth, and development of Manitoba communities, and the archives staff conducted local history workshops for over 200 Manitoba residents and provided reference, referral, public relations, and consultation services. In addition to a summary of activities, the report includes a message from the Board Chairperson, a listing of members of the Board of Directors, the financial report, and a collage of newspaper clippings highlighting the year's work. (NEC)

Published
1978

16. The Study of Sequential Student Participation in University in a Changing Environment.

Author

Brandon Univ. (Manitoba)., Lam, Jack, and Hoffman, Ben

Abstract

The factors influencing attendance at Brandon University, Manitoba, Canada, by 1978 high school graduates were studied. Students who had participated in the Post-Secondary Demand and Enrollment Survey of November 1977 and had selected Brandon University as their first choice institution, and randomly selected students who had applied and been accepted by the university were studied. From these two samples, subgroups of students who subsequently attended the university (going) and who did not attend the university (not going) were compared. The study questionnaire attempted to determine the most important persons influencing the students' decisions to continue or not to continue higher education; events that occurred in high school and summer that might have some impact upon students' immediate plans in the fall; problem areas that students might encounter in their planning; and their educational objectives, career plans, and foreseeable obstacles in fulfilling their plans. Specific information was obtained on students' geographic origins, commuter status, summer employment, and degree of certainty as related to financing the first year of college and as related to achieving their aspirations. The dominant explanation for students not attending Brandon University focuses on insufficient funds. Among the factors that discriminated between the going and the not going groups were the following: preparation for a specific life style, teacher and parent influence, and ability to overcome problems. Recommendations to increase attendance are offered, including financial aid options and marketing efforts. (SW)

Published
1979

17. Native Studies Programs in Canada and the United States.

Author

Brandon Univ. (Manitoba). and Sikand, Jack

Abstract

Defining Native studies programs in Canada and the U.S., this essay presents: (1) Rationale for Native Studies (recognition on the part of the majority of cultural differences; the emergence of an affirmative Native identity; and declining enrollments in colleges); (2) Structural Organization Alternatives (as part of an existing department; as an interdisciplinary program; as a separate degree-awarding department); (3) Goals (to provide cultural awareness for persons preparing to work among Native populations; to provide Native students with a sense of belonging and an indigenous belief system that would provide ethical moorings; to enable Native students to develop an identification with the formal educational system; to provide a forum for discussion of the solution to Native problems; to preserve and promote Native heritage; to promote non-partisan intellectual activity; to serve as an unofficial co-ordinator of other Native programs); (4) Recommendations (development of a Native studies periodical and professional conference to promote idea exchange; formation of a North American Native studies organization to facilitate development of a Native university and to exert political influence upon the administration of Native programs; encouragement/assistance to scholars in Native studies by government and industry; deliberate and courageous Native studies goal clarification/articulation; greater commitment to the academic aspects of Native studies). (JC)

Published
1976

18. Study of Flare Assessment in Systemic Lupus Erythematosus Based on Paper Patients

Author

1 UCL, London, England Show more 2 Hosp Trop Dis, London, England Show more 3 Feinstein Inst Med Res, Manhasset, NY USA Show more 4 Columbia Univ, New York, NY USA Show more 5 Hanyang Univ Hosp Rheumat Dis, Seoul, South Korea Show more 6 McGill Univ, Quebec City, PQ, Canada Show more 7 Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England Show more 8 Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England 9 New York Sch Med, New York, NY USA Show more 10 Univ Barcelona, Barcelona, Spain Show more 11 Univ Calgary, Cumming Sch Med, Calgary, AB, Canada Show more 12 Univ N Carolina, Chapel Hill, NC USA Show more 13 Univ Laval, Quebec City, PQ, Canada 14 Downstate Med Ctr Rheumatol, Brooklyn, NY USA Show more 15 Toronto Western Hosp, Krembil Res Inst, Toronto, ON, Canada Show more 16 Univ Toronto, Toronto, ON, Canada Show more 17 Nova Scotia Rehabil Ctr, Halifax, NS, Canada Show more 18 Istanbul Univ, Istanbul, Turkey Show more 19 Rigshosp, Copenhagen, Denmark 20 Med Univ South Carolina, Charleston, SC USA Show more 21 Kings Coll London, London, England Show more 22 Emory Univ, Atlanta, GA 30322 USA 23 Allegheny Hlth Network, Pittsburgh, PA USA Show more 24 Lund Univ, Lund, Sweden Show more 25 Univ Manitoba, Winnipeg, MB, Canada Show more 26 Johns Hopkins Univ, Baltimore, MD USA Show more 27 Univ Calif San Diego, San Diego, CA 92103 USA Show more 28 Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA Show more 29 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico 30 Hosp Univ Cruces & Univ Basque Country, Baracaldo, Spain Show more 31 Mt Sinai Hosp, Toronto, ON, Canada Show more 32 Univ Hlth Network, Toronto, ON, Canada Show more 33 Univ Toronto, Toronto, ON, Canada Show more 34 Landspitali Univ Hosp, Reykjavik, Iceland Show more 35 Karolinska Univ Hosp, Solna, Sweden Show mor, University College London; London UK, The Hospital For Tropical Diseases; London UK, Feinstein Institute for Medical Research; Manhasset New York, Columbia University; New York New York, Hanyang University Hospital for Rheumatic Diseases; Seoul South Korea, McGill University; Quebec Ontario Canada, The University of Manchester; Central Manchester University Hospitals NHS Foundation Trust and Manchester Academic Health Science Centre; Manchester UK, New York School of Medicine; New York, Universitat de Barcelona; Barcelona Spain, Cumming School of Medicine; University of Calgary; Calgary Alberta Canada, University of North Carolina; Chapel Hill, Université Laval; Quebec City Québec Canada, Downstate Medical Center Rheumatology; Brooklyn New York, Krembil Research Institute; Toronto Western Hospital; University of Toronto; Toronto Ontario Canada, Nova Scotia Rehabiliation Center; Halifax Nova Scotia Canada, Istanbul University; Istanbul Turkey, Rigshospitalet; Copenhagen Denmark, Medical University of South Carolina; Charleston UK, King's College London; London UK, Emory University; Atlanta Georgia, Allegheny Health Network; Pittsburgh Pennsylvania, Lund University; Lund Sweden, University of Manitoba; Winnipeg Manitoba Canada, Johns Hopkins University; Baltimore Maryland, University of California at San Diego; Chicago Illinois, Northwestern University; Feinberg School of Medicine; Chicago Illinois, Instituto Nacional de Ciencias Médicas y Nutrición; Mexico City Mexico, Hospital Universitario Cruces and University of the Basque Country; Barakaldo Spain, Mount Sinai Hospital and University Health Network and University of Toronto; Toronto Ontario Canada, Landspitali University Hospital; Reykjavik Iceland, Karolinska University Hospital; Solna Sweden, University of California at Los Angeles; Scotland UK, Hairmyres Hospital; East Kilbride Scotland UK, Oklahoma Medical Research Foundation; Oklahoma City UK, College of Medical and Dental Sciences; University of Birmingham; Birmingham UK, Isenberg, D., Sturgess, J., Allen, E., Aranow, C., Askanase, A., Sang-Cheol, B., Bernatsky, S., Bruce, I., Buyon, J., Cervera, R., Clarke, A., Dooley, Mary Anne, Fortin, P., Ginzler, E., Gladman, D., Hanly, J., Inanc, M., Jacobsen, S., Kamen, D., Khamashta, M., Lim, S., Manzi, S., Nived, O., Peschken, C., Petri, M., Kalunian, K., Rahman, A., Ramsey-Goldman, R., Romero-Diaz, J., Ruiz-Irastorza, G., Sanchez-Guerrero, J., Steinsson, K., Sturfelt, G., Urowitz, M., Van Vollenhoven, R., Wallace, D.J., Zoma, A., Merrill, J., Gordon, C., 1 UCL, London, England Show more 2 Hosp Trop Dis, London, England Show more 3 Feinstein Inst Med Res, Manhasset, NY USA Show more 4 Columbia Univ, New York, NY USA Show more 5 Hanyang Univ Hosp Rheumat Dis, Seoul, South Korea Show more 6 McGill Univ, Quebec City, PQ, Canada Show more 7 Univ Manchester, Cent Manchester Univ Hosp NHS Fdn Trust, Manchester, Lancs, England Show more 8 Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England 9 New York Sch Med, New York, NY USA Show more 10 Univ Barcelona, Barcelona, Spain Show more 11 Univ Calgary, Cumming Sch Med, Calgary, AB, Canada Show more 12 Univ N Carolina, Chapel Hill, NC USA Show more 13 Univ Laval, Quebec City, PQ, Canada 14 Downstate Med Ctr Rheumatol, Brooklyn, NY USA Show more 15 Toronto Western Hosp, Krembil Res Inst, Toronto, ON, Canada Show more 16 Univ Toronto, Toronto, ON, Canada Show more 17 Nova Scotia Rehabil Ctr, Halifax, NS, Canada Show more 18 Istanbul Univ, Istanbul, Turkey Show more 19 Rigshosp, Copenhagen, Denmark 20 Med Univ South Carolina, Charleston, SC USA Show more 21 Kings Coll London, London, England Show more 22 Emory Univ, Atlanta, GA 30322 USA 23 Allegheny Hlth Network, Pittsburgh, PA USA Show more 24 Lund Univ, Lund, Sweden Show more 25 Univ Manitoba, Winnipeg, MB, Canada Show more 26 Johns Hopkins Univ, Baltimore, MD USA Show more 27 Univ Calif San Diego, San Diego, CA 92103 USA Show more 28 Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA Show more 29 Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico 30 Hosp Univ Cruces & Univ Basque Country, Baracaldo, Spain Show more 31 Mt Sinai Hosp, Toronto, ON, Canada Show more 32 Univ Hlth Network, Toronto, ON, Canada Show more 33 Univ Toronto, Toronto, ON, Canada Show more 34 Landspitali Univ Hosp, Reykjavik, Iceland Show more 35 Karolinska Univ Hosp, Solna, Sweden Show mor, University College London; London UK, The Hospital For Tropical Diseases; London UK, Feinstein Institute for Medical Research; Manhasset New York, Columbia University; New York New York, Hanyang University Hospital for Rheumatic Diseases; Seoul South Korea, McGill University; Quebec Ontario Canada, The University of Manchester; Central Manchester University Hospitals NHS Foundation Trust and Manchester Academic Health Science Centre; Manchester UK, New York School of Medicine; New York, Universitat de Barcelona; Barcelona Spain, Cumming School of Medicine; University of Calgary; Calgary Alberta Canada, University of North Carolina; Chapel Hill, Université Laval; Quebec City Québec Canada, Downstate Medical Center Rheumatology; Brooklyn New York, Krembil Research Institute; Toronto Western Hospital; University of Toronto; Toronto Ontario Canada, Nova Scotia Rehabiliation Center; Halifax Nova Scotia Canada, Istanbul University; Istanbul Turkey, Rigshospitalet; Copenhagen Denmark, Medical University of South Carolina; Charleston UK, King's College London; London UK, Emory University; Atlanta Georgia, Allegheny Health Network; Pittsburgh Pennsylvania, Lund University; Lund Sweden, University of Manitoba; Winnipeg Manitoba Canada, Johns Hopkins University; Baltimore Maryland, University of California at San Diego; Chicago Illinois, Northwestern University; Feinberg School of Medicine; Chicago Illinois, Instituto Nacional de Ciencias Médicas y Nutrición; Mexico City Mexico, Hospital Universitario Cruces and University of the Basque Country; Barakaldo Spain, Mount Sinai Hospital and University Health Network and University of Toronto; Toronto Ontario Canada, Landspitali University Hospital; Reykjavik Iceland, Karolinska University Hospital; Solna Sweden, University of California at Los Angeles; Scotland UK, Hairmyres Hospital; East Kilbride Scotland UK, Oklahoma Medical Research Foundation; Oklahoma City UK, College of Medical and Dental Sciences; University of Birmingham; Birmingham UK, Isenberg, D., Sturgess, J., Allen, E., Aranow, C., Askanase, A., Sang-Cheol, B., Bernatsky, S., Bruce, I., Buyon, J., Cervera, R., Clarke, A., Dooley, Mary Anne, Fortin, P., Ginzler, E., Gladman, D., Hanly, J., Inanc, M., Jacobsen, S., Kamen, D., Khamashta, M., Lim, S., Manzi, S., Nived, O., Peschken, C., Petri, M., Kalunian, K., Rahman, A., Ramsey-Goldman, R., Romero-Diaz, J., Ruiz-Irastorza, G., Sanchez-Guerrero, J., Steinsson, K., Sturfelt, G., Urowitz, M., Van Vollenhoven, R., Wallace, D.J., Zoma, A., Merrill, J., and Gordon, C.

Abstract

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files, OBJECTIVE: To determine the level of agreement of disease flare severity (distinguishing severe, moderate, and mild flare and persistent disease activity) in a large paper-patient exercise involving 988 individual cases of systemic lupus erythematosus. METHODS: A total of 988 individual lupus case histories were assessed by 3 individual physicians. Complete agreement about the degree of flare (or persistent disease activity) was obtained in 451 cases (46%), and these provided the reference standard for the second part of the study. This component used 3 flare activity instruments (the British Isles Lupus Assessment Group [BILAG] 2004, Safety of Estrogens in Lupus Erythematosus National Assessment [SELENA] flare index [SFI] and the revised SELENA flare index [rSFI]). The 451 patient case histories were distributed to 18 pairs of physicians, carefully randomized in a manner designed to ensure a fair case mix and equal distribution of flare according to severity. RESULTS: The 3-physician assessment of flare matched the level of flare using the 3 indices, with 67% for BILAG 2004, 72% for SFI, and 70% for rSFI. The corresponding weighted kappa coefficients for each instrument were 0.82, 0.59, and 0.74, respectively. We undertook a detailed analysis of the discrepant cases and several factors emerged, including a tendency to score moderate flares as severe and persistent activity as flare, especially when the SFI and rSFI instruments were used. Overscoring was also driven by scoring treatment change as flare, even if there were no new or worsening clinical features. CONCLUSION: Given the complexity of assessing lupus flare, we were encouraged by the overall results reported. However, the problem of capturing lupus flare accurately is not completely solved.

20. Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Author

Zeineb, Zian, Brown, Peter, Tan, Aik-Choon, El-Esawi, Mohamed A., Liehr, Thomas, Blanck, Oliver, Gladue, Douglas P., Almeida, Gabriel M. F., Cernava, Tomislav, Sorzano, Carlos O., Yeung, Andy W. K., Engel, Michael S., Chandrasekaran, Arun Richard, Muth, Thilo, Staege, Martin S., Daulatabad, Swapna V., Widera, Darius, Zhang, Junpeng, Meule, Adrian, Honjo, Ken, Pourret, Olivier, Yin, Cong-Cong, Zhang, Zhongheng, Cascella, Marco, Flegel, Willy A., Goodyear, Carl S., Raaij, Mark J. van, Bukowy-Bieryllo, Zuzanna, Campana, Luca G., Kurniawan, Nicholas A., Lalaouna, David, Hüttner, Felix J., Ammerman, Brooke A., Ehret, Felix, Cobine, Paul A., Tan, Ene-Choo, Han, Hyemin, Xia, Wenfeng, McCrum, Christopher, Dings, Ruud P. M., Marinello, Francesco, Nilsson, Henrik, Nixon, Brett, Voskarides, Konstantinos, Yang, Long, Costa, Vincent D., Bengtsson-Palme, Johan, Bradshaw, William, Grimm, Dominik G., Kumar, Nitin, Martis, Elvis, Prieto, Daniel, Sabnis, Sandeep C., Amer, Said E. D. R., Liew, Alan W. C., Perco, Paul, Rahimi, Farid, Riva, Giuseppe, Zhang, Chongxing, Devkota, Hari P., Ogami, Koichi, Basharat, Zarrin, Fierz, Walter, Siebers, Robert, Tan, Kok-Hian, Boehme, Karen A., Brenneisen, Peter, Brown, James A. L., Dalrymple, Brian P., Harvey, David J., Ng, Grace, Werten, Sebastiaan, Bleackley, Mark, Dai, Zhanwu, Dhariwal, Raman, Gelfer, Yael, Hartmann, Marcus D., Miotla, Pawel, Tamaian, Radu, Govender, Pragashnie, Gurney-Champion, Oliver J., Kauppila, Joonas H., Zhang, Xiaolei, Echeverría, Natalia, Subhash, Santhilal, Sallmon, Hannes, Tofani, Marco, Bae, Taeok, Bosch, Oliver, Cuív, Páraic O., Danchin, Antoine, Diouf, Barthelemy, Eerola, Tuomas, Evangelou, Evangelos, Filipp, Fabian V., Klump, Hannes, Kurgan, Lukasz, Smith, Simon S., Terrier, Olivier, Tuttle, Neil, Ascher, David B., Janga, Sarath C., Schulte, Leon N., Becker, Daniel, Browngardt, Christopher, Bush, Stephen J., Gaullier, Guillaume, Ide, Kazuki, Meseko, Clement, Werner, Gijsbert D. 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H., Xavier, Rose M., Xiao, Shumin, Xiong, Peng, Xu, Shicai, Xu, Shilin, Yao, Ruifeng, Yao, Wen, Yin, Qinan, Yu, Yongbo, Zaitsu, Masayoshi, Zhan, Xiao-Yong, Zhang, Jilei, Zhang, Rongqiang, Zhang, Wei, Zhang, Xianglilan, Zheng, Shan, Zhou, Bailing, Zhou, Xiaoyan, Ahmad, Haroon, Akinwumi, Sayo A., Albery, Gregory F., Alhowimel, Ahmed, Ali, Junaid, Alshehri, Mansour, Alsuhaibani, Mohammed, Anikin, Andrey, Azubuike, Samuel O., Bach-Mortensen, Anders, Baltiansky, Lior, Bartas, Martin, Belachew, Kiflemariam Y., Bhardwaj, Vivek, Binder, Karin, Bland, Nicholas S., Boah, Michael, Bullen, Benjamin, Calabrò, Giovanna E., Callahan, Tiffany J., Cao, Bing, Chalmers, Kelsey, Chang, Wei, Che, Zhengping, Chen, Andrew T. Y., Chen, Haimin, Chen, Huaming, Chen, Youning, Chen, Zhao, Choi, YoungRok, Chowdhury, Mohiuddin A. K., Christensen, Martin R., Cooke, Robert S. 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Univ, Univ Exeter, Hillingdon Hosp NHS Fdn Trust, Natl & Kapodistrian Univ Athens, Lausanne Univ Hosp, Queens Univ Belfast, Cold Spring Harbor Lab, Hosp Clin Porto Alegre, Univ Paris 05, Indian Inst Adv Res, Bambino Ges Childrens Res Hosp, Univ Cadiz, Mansoura Univ Hosp, Ctr Expertise & Biol Diagnost Cameroon, Swiss Fed Labs Mat Sci & Technol, Assiut Univ, Univ Derby, SUNY Stony Brook, Walter & Eliza Hall Inst Med Res, Janelia Res Campus, USDA ARS, Med Univ Graz, Ajou Univ, Univ Dundee, Tech Univ Dresden, Natl Univ Hlth Syst, Univ Canterbury, Univ Hosp Southern Denmark, Baylor Coll Med, Adnan Menderes Univ Aydin, Oasi Res Inst IRCCS, LSHTM, Leibniz Univ Hannover, Xi An Jiao Tong Univ, Shenzhen Univ, Cent South Univ, Univ Bridgeport, Texas Tech Univ, Univ Montana, NHLBI, Cleveland Clin, NARO, Eduardo Mondlane Univ, RAS, Beijing Inst Technol, Univ Hlth Network, Univ Bath, Fisheries & Oceans Canada, Queensland Govt, Uppsala Univ, Childrens Canc Hosp, Leibniz Inst Nat Prod Res & Infect 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Univ Calif Irvine, Univ Hosp Leuven, Chongqing Med Univ, Childrens Hosp Kings Daughters, China Three Gorges Univ, and Xiangtan Univ

Subjects
Technology and Engineering, SCIENTIFIC SEARCH, Expert-curated database, Biokemia, solu- ja molekyylibiologia - Biochemistry, cell and molecular biology, Databases, RElevant LIterature SearcH consortium, Medicine and Health Sciences, Biomedical research, benchmarking, Biology, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Settore MED/42 - IGIENE GENERALE E APPLICATA, database, Computer. Automation, Science & Technology, 0804 Data Format, relisch, Scientific research in health sciences, Mathematics and Statistics, litearture search, relisch , database, biomedical research, Biomedical literature, Original Article, RELISH, Mathematical & Computational Biology, RECOMMENDER-SYSTEMS, Life Sciences & Biomedicine, Mathematics, 0807 Library and Information Studies
Abstract

Made available in DSpace on 2020-12-11T01:57:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-10-29 Griffith University Gowonda HPC Cluster Queensland Cyber Infrastructure Foundation Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research. Griffith Univ, Sch Informat & Commun Technol, Gold Coast, Qld 4222, Australia Griffith Univ, Inst Glyc, Gold Coast, Qld 4222, Australia Univ Colorado, Dept Med Med Oncol, Anschutz Med Campus, Denver, CO USA Tanta Univ, Fac Sci, Bot Dept, Tanta, Egypt Friedrich Schiller Univ, Jena Univ Hosp, Inst Human Genet, Jena, Germany Univ Med Ctr Schleswig Holstein, Dept Radiat Oncol, Campus Kiel, Kiel, Germany ARS, USDA, Plum Isl Anim Dis Ctr, Greenport, NY 11944 USA Univ Jyvaskyla, Dept Biol & Environm Sci, Jyvaskyla, Finland Graz Univ Technol, Inst Environm Biotechnol, Graz, Austria CSIC, CNB, Natl Biotechnol Ctr, Dept Macromol Struct, Madrid, Spain Univ Hong Kong, Fac Dent, Oral & Maxillofacial Radiol Appl Oral Sci & Commu, Hong Kong, Peoples R China Univ Kansas, Div Entomol, Biodivers Inst, Lawrence, KS 66045 USA SUNY Albany, RNA Inst, Albany, NY 12222 USA Robert Koch Inst, Dept Methods Dev & Res Infrastruct, Berlin, Germany Martin Luther Univ Halle Wittenberg, Dept Surg & Conservat Pediat & Adolescent Med, Halle, Germany Indiana Univ Purdue Univ, IU Sch Informat & Comp, Dept BioHlth Informat, Indianapolis, IN 46202 USA Univ Reading, Sch Pharm Stem Cell Biol & Regenerat Med, Reading, Berks, England Dali Univ, Sch Engn, Dali City, Yunnan, Peoples R China Univ Hosp Munich LMU, Dept Psychiat & Psychotherapy, Munich, Germany Univ Tsukuba, Fac Life & Environm Sci, Ibaraki, Japan UniLaSalle, Aghyle, Beauvais, France Henry Ford Hlth Syst, Dept Immunol, Detroit, MI USA Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Emergency, Hangzhou 310016, Zhejiang, Peoples R China Ist Nazl Tumori Fdn Pascale IRCCS, Anesthesia & Pain Med, Naples, Italy NIH, Dept Transfus Med, Bethesda, MD USA Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland Polish Acad Sci, Inst Human Genet, Poznan, Poland Univ Padua, Dept Surg Oncol & Gastroenterol DISCOG, Padua, Italy Eindhoven Univ Technol, Biomed Engn, Eindhoven, Netherlands Univ Strasbourg, IBMC, Strasbourg, France Heidelberg Univ, Dept Gen Visceral & Transplantat Surg, Heidelberg, Germany Univ Notre Dame, Psychol, Notre Dame, IN 46556 USA Harvard Med Sch, Massachusetts Gen Hosp, Radiol & Pathol, Boston, MA 02115 USA Auburn Univ, Dept Biol Sci, Auburn, AL 36849 USA KK Womens & Childrens Hosp, KK Res Ctr, Singapore, Singapore Univ Alabama, Educ Psychol, Tuscaloosa, AL USA UCL, Wellcome EPSRC Ctr Intervent & Surg Sci, London, England Maastricht Univ, Dept Nutr & Movement Sci, Maastricht, Netherlands Univ Arkansas Med Sci, Dept Radiat Oncol, Little Rock, AR 72205 USA Univ Padua, Dept Land Environm Agr & Forestry, Padua, Italy Univ Gothenburg, Dept Biol & Environm Sci, Gothenburg, Sweden Univ Newcastle, Prior Res Ctr Reprod Sci, Callaghan, NSW, Australia Univ Cyprus, Med Sch, Nicosia, Cyprus Shandong Agr Univ, Coll Plant Protect, Agr Big Data Res Ctr, Tai An, Shandong, Peoples R China NIMH, Neuropsychol Lab, Bldg 9, Bethesda, MD 20892 USA Univ Wisconsin, Wisconsin Inst Discovery, Madison, WI USA Univ Oxford, Struct Genom Consortium, Oxford, England Weihenstephan Triesdorf Univ Appl Sci, TUM Campus Straubing Biotechnol & Sustainabil, Bioinformat, Straubing, Germany Univ Michigan, Cardiovasc Res, Ann Arbor, MI 48109 USA Bombay Coll Pharm, Pharmaceut Chem, Mumbai, Maharashtra, India Inst Invest Biol Clemente Estable, Dev Neurobiol, Montevideo, Uruguay Gem Hosp & Res Ctr, Surg Gastroenterol & HPB Surg, Coimbatore, Tamil Nadu, India Kafr El Sheikh Univ, Fac Sci, Dept Zool, Kafr Al Sheikh, Egypt Med Univ Innsbruck, Dept Internal Med 4, Innsbruck, Austria Australian Natl Univ, Div Biomed Sci & Biochem, Canberra, ACT, Australia Univ Cattolica Sacro Cuore, Appl Technol Neuropsychol Lab, Milan, Italy Shandong Inst Parasit Dis, Med Entomol, Jinan, Shandong, Peoples R China Kumamoto Univ, Sch Pharm, Kumamoto, Japan Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Biol Chem, Nagoya, Aichi, Japan Univ Karachi, ICCBS, PCMD, Jamil ur Rahman Ctr Genome Res, Karachi 75270, Pakistan Labormed Zentrum Dr Risch, Vaduz, Liechtenstein Univ Otago, Med, Dunedin, New Zealand KK Womens & Childrens Hosp, Maternal Fetal Med, Singapore, Singapore Albert Ludwigs Univ Freiburg, GERN Tissue Replacement Regenerat & Neogenesis, Dept Orthoped & Trauma Surg, Med Ctr,Fac Med, Freiburg, Germany Heinrich Heine Univ, Inst Biochem & Mol Biol, Dusseldorf, Germany Natl Univ Ireland Galway, Surg, Galway, Ireland Univ Western Australia, Inst Agr, Perth, WA, Australia Univ Oxford, Nuffield Dept Med, Oxford, England SingHlth Polyclin, Punggol Polyclin, Singapore, Singapore Med Univ Innsbruck, Bioctr, Div Biol Chem, Innsbruck, Austria La Trobe Univ, La Trobe Inst Mol Sci, Biochem & Genet, Melbourne, Vic, Australia Univ Bordeaux, INRA, Bordeaux, France Agr & Agri Food Canada, Lethbridge Res & Dev Ctr, Lethbridge, AB, Canada St George Hosp, Trauma & Orthopaed, London, England Max Planck Inst Dev Biol, Dept Prot Evolut, Tubingen, Germany Med Univ Lublin, Dept Gynaecol 2, Lublin, Poland ICIT, ICSI Analyt Natl Res & Dev, Ramnicu Valcea, VL, Romania Univ KwaZulu Natal, Occupat Therapy, Westville Campus, Durban, South Africa Inst Canc Res, Joint Dept Phys, London, England Karolinska Inst, Dept Mol Med & Surg, Solna, Sweden Wenzhou Med Univ, Affiliated Hosp 2, Orthopaed, Wenzhou, Zhejiang, Peoples R China Univ Republica, Fac Ciencias, Ctr Invest Nucl, Lab Virol Mol, Montevideo, Uruguay Univ Gothenburg, Dept Med Biochem & Cell Biol, Gothenburg, Sweden Charite Med Univ Berlin, Pediat Cardiol, Berlin, Germany Bambino Gesu Pediat Hosp, Dept Neurosci & Neurorehabil, Neurorehabil Unit, Rome, Italy Indiana Univ Sch Med Northwest, Microbiol & Immunol, Gary, IN USA Univ Regensburg, Dept Behav & Mol Neurobiol, Regensburg, Germany Univ Queensland, Diamantina Inst, Brisbane, Qld, Australia Translat Res Inst, Brisbane, Qld, Australia Univ Hong Kong, Sch Biomed Sci, Hong Kong, Peoples R China St Jude Childrens Res Hosp, Pharmaceut Sci Dept, 332 N Lauderdale St, Memphis, TN 38105 USA Univ Durham, Mus, Durham, England Univ Ioannina, Med Sch, Dept Hyg & Epidemiol, Ioannina, Greece Tech Univ Munich, Sch Life Sci Weihenstephan, Maximus von Imhof Forum 3, D-85354 Freising Weihenstephan, Germany Univ Hosp Essen, Inst Transfus Med, Essen, Germany Virginia Commonwealth Univ, Comp Sci, Richmond, VA USA Univ Queensland, Inst Social Sci Res, Brisbane, Qld, Australia Univ Lyon, Ctr Int Rech Infectiol, Lyon, France Griffith Univ, Sch Allied Hlth Sci, Gold Coast, Qld, Australia Univ Melbourne, Dept Biochem & Mol Biol, Parkville, Vic, Australia Indiana Univ Purdue Univ, Dept Biohlth Informat, Sch Informat & Comp, Indianapolis, IN 46202 USA Philipps Univ Marburg, Inst Lung Res, Marburg, Germany Indiana Univ, Dept Biol, Bloomington, IN USA Univ Florida, Oral Biol, Gainesville, FL USA Univ Colorado, Dept Biochem, Boulder, CO 80309 USA Kyoto Univ, Ctr Promot Interdisciplinary Educ & Res, Kyoto, Japan Friedrich Loeffler Inst, Inst Virus Diagnost, Greifswald, Germany Univ Oxford, Dept Zool, Oxford, England Tech Univ Munich, Dept Bioinformat, Munich, Germany Univ Adelaide, Sch Anim & Vet Sci, Adelaide, SA, Australia Stanford Univ, Canc Biol, Palo Alto, CA 94304 USA Covenant Univ, Dept Elect & Informat Engn, Ota, Nigeria Heinrich Heine Univ, Inst Stem Cell Res & Regenerat Med, Dusseldorf, Germany Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada Albert Einstein Coll Med, Psychiat, New York, NY USA Akdeniz Univ, Med Biol & Genet, Antalya, Turkey NIMH, NIH, Bethesda, MD 20892 USA Med Univ Hosp, Internal Med 1, Tubingen, Germany NET ESolut, Netelabs, Mclean, VA USA Univ Southern Denmark, Inst Publ Hlth, Odense, Denmark John Innes Ctr, Mol Microbiol, Norwich, Norfolk, England Univ Adelaide, Waite Res Precinct, Australian Res Council, Ctr Excellence Plant Energy Biol, Adelaide, SA, Australia Univ Cambridge, Cambridge Inst Publ Hlth, Cambridge, England Univ Munster, Inst Biochem, Munster, Germany Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth RSPH, Canberra, ACT, Australia Stanford Univ, Neurobiol & Bioengn, Palo Alto, CA 94304 USA Univ Birmingham, Geog Earth & Environm Sci, Birmingham, W Midlands, England Murdoch Univ, Sch Vet & Life Sci, Perth, WA, Australia George Mason Univ, Ctr Climate Change Commun, Fairfax, VA 22030 USA Univ Adelaide, Sch Agr Food & Wine, Adelaide, SA, Australia Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China Stanford Univ, Pathol, Palo Alto, CA 94304 USA Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy Univ Padua, Dept Gen Psychol, Padua, Italy Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Dept Bioinformat & Syst Biol, Key Lab Mol Biophys,Minist Educ, Wuhan, Hubei, Peoples R China Huazhong Univ Sci & Technol, Collaborat Innovat Ctr Biomed Engn, Wuhan, Hubei, Peoples R China Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia French Natl Ctr Sci Res, CNRS, Inst Biol Physicochim, Paris, France Univ Warwick, Dept Sociol, Coventry, W Midlands, England European Mol Biol Lab, Struct & Computat Biol, Heidelberg, Germany Univ Cincinnati, Coll Med, Canc Biol, Cincinnati, OH USA Univ Waterloo, Biol, Waterloo, ON, Canada Sorbonne Univ, CNRS, Integrat Biol Marine Models LBI2M, SBR, Roscoff, France Univ Manitoba, Biochem & Med Genet, Winnipeg, MB, Canada Max Planck Inst Solid State Res, Ultrafast Solid State Spect, Stuttgart, Germany Imperial Coll London, Sch Publ Hlth, Dept Infect Dis Epidemiol, London, England Mansoura Univ, Fac Vet Med, Biochem, Mansoura, Egypt Univ Virginia, Mol Physiol & Biol Phys, Charlottesville, VA USA China Univ Geosci, State Key Lab Biogeol & Environm Geol, Wuhan, Hubei, Peoples R China Clin Neurol & Psychiat Children & Youth, Child Psychiat, Belgrade, Serbia Ahvaz Jundishapur Univ Med Sci, Med Phys, Ahwaz, Iran Univ Iowa City, Coll Dent, Div Biostat & Computat Biol, Dept Prevent & Community Dent, Iowa City, IA USA Univ Iowa City, Coll Dent, Div Biostat & Computat Biol, Dept Biomed Engn, Iowa City, IA USA Univ Iowa City, Coll Dent, Div Biostat & Computat Biol, Dept Biostat, Iowa City, IA USA Univ Tubingen, Inst Med Psychol & Behav Neurobiol, Tubingen, Germany Univ Ibadan, Dept Zool, Ibadan, Nigeria Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA Univ Tasmania, Sch Technol Environm & Design, Discipline ICT, Hobart, Tas, Australia Childrens Mercy Hosp, Radiol, Kansas City, MO 64108 USA Stockholm Univ, Dept Phys, Stockholm, Sweden Oslo Univ Hosp, Inst Canc Genet & Informat, Oslo, Norway CSIRO, CSIRO Mfg, Pullenvale, Qld, Australia Johns Hopkins Sch Med, Urol, Baltimore, MD USA Univ South Africa, Life & Consumer Sci, Johannesburg, South Africa German Ctr Neurodegenerat Dis, Mech Induced Plast Brain, Bonn, Germany UCL, Inst Child Hlth, Dev Biol & Canc, London, England Simon Fraser Univ, Biomed Physiol & Kinesiol, Burnaby, BC, Canada Univ Manchester, Ctr Hlth Informat, Manchester, Lancs, England Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia Albert Einstein Coll Med, Dept Med, New York, NY USA Georgetown Univ, Kennedy Inst Eth, Washington, DC 20057 USA Dermatol Skin & Canc Fdn, Carlton, Vic, Australia Med Coll Wisconsin, Div Hematol, Milwaukee, WI 53226 USA Med Coll Wisconsin, Div Oncol, Milwaukee, WI 53226 USA Med Coll Wisconsin, Div Infect Dis, Milwaukee, WI 53226 USA US FDA, Off Biotechnol Prod, Washington, DC 20204 USA Worcester Polytech Inst, Biomed Engn, Worcester, MA 01609 USA Univ Adelaide, Ctr Orthopaed & Trauma Res, Adelaide, SA, Australia Publ Hlth England, Natl Infect Serv, Bristol, Avon, England Univ Utrecht, Fac Sci Chem, Utrecht, Netherlands Natl Univ Ireland Galway, Pathol, Galway, Ireland Imperial Coll London, NHLI, London, England Danube Private Univ, Neurodegenerat, Krems Donau, Austria Imperial Coll London, Dept Chem, London, England Univ Helsinki, Finnish Museum Nat Hist, Helsinki, Finland Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia Univ Nottingham, Nottingham Digest Dis Ctr, Nottingham, England Univ Toulouse, CNRS, ITAV, USR3505, Toulouse, France ASCR, Inst Mol Genet, CZ Openscreen, Prague, Czech Republic Univ Turku, Inst Biomed, Turku, Finland York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON, Canada Univ Calif Los Angeles, Stein Eye Inst, Ophthalmol, Los Angeles, CA USA Agr & Agri Food Canada, Ottawa Res & Dev Ctr, Ottawa, ON, Canada Helmholtz Zentrum Geesthacht, Mat Design & Characterizat, Geesthacht, Germany Unvers Genova, Internal Med, Genoa, Italy Otto von Guericke Univ, Intelligent Catheter INKS, Magdeburg, Germany Univ Toledo, Canc Biol, 2801 W Bancroft St,Hlth Sci Campus, Toledo, OH 43606 USA CRUK Beatson Inst, Struct Biol, Glasgow, Lanark, Scotland Leibniz Inst Primate Res, Med RNA Biol, Gottingen, Germany Univ Limoges, PEIRENE, EA 7500, Limoges, France Hainan Univ, Vet Med, Haikou, Hainan, Peoples R China UCL, Sch Pharam, Pharmacognosy & Phytotherapy, London, England Univ Oulu, Ecol & Genet Res Unit, Oulu, Finland Rhein Westfal TH Aachen, Inst Biochem & Mol Immunol, Aachen, Germany Univ Stuttgart, Inst Biochem & Tech Biochem, Stuttgart, Germany Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, Shenzhen, Peoples R China GIGA Res Inst, Med Oncol, Liege, Belgium CHULiege, Liege, Belgium Fdn Bruno Kessler, MPBA, Trento, Italy Hokkaido Univ, Grad Sch Med, Dept Neurobiol, Sapporo, Hokkaido, Japan Univ Leuven, Oncol, Leuven, Belgium Chalmers Univ Technol, Dept Math Sci, Gothenburg, Sweden Radboud Univ Nijmegen, Med Ctr, Dept Neurol, Nijmegen, Netherlands Univ South Australia, Sch Informat Technol & Math Sci, Adelaide, SA, Australia Bio Thera Solut Ltd, Dept Computat Biol, Guangzhou, Guangdong, Peoples R China Inst Invest Biosanitario Granada IBS, Otolaryngol, Granada, Spain Curtin Univ, Sch Mol & Life Sci, Perth, WA, Australia Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England Goethe Univ, Biol DCAL, Inst Pharm, Frankfurt, Germany Univ Lyon, ICBMS, UMR 5246, Lyon, France Inst Pasteur, Dept Genomes & Genet, Paris, France Univ Valencia, Pharmacol, Valencia, Spain Council Agr Res & Econ, Res Ctr Olive Citrus & Tree Fruit, Caserta, Italy Fraunhofer Inst Toxicol & Expt Med ITEM, Preclin Pharmacol & Vitro Toxicol, Hannover, Germany Univ Tasmania, Sch Med, Hobart, Tas, Australia Chugai Pharmaceut Co Ltd, Oncol Lifecycle Management Dept, Tokyo, Japan Univ Lubeck, Inst Neurobiol, Lubeck, Germany NYU, Sch Med, Neurol, New York, NY USA Univ Putra Malaysia, Dept Plant Pathol, Seri Kembangan, Malaysia Univ N Carolina, Biol, Chapel Hill, NC 27515 USA Univ Southampton, Fac Hlth Sci, Southampton, Hants, England Univ Highlands & Islands, Genet & Immunol Res Grp, Inverness, Scotland Heidelberg Univ, Inst Pathol, Heidelberg, Germany Indraprastha Inst Informat Technol, Dept Computat Biol, New Delhi, India Glasgow Caledonian Univ, Sch Hlth & Life Sci, Glasgow, Lanark, Scotland Liverpool John Moores Univ, Pharm & Biomol Sci, Liverpool, Merseyside, England Parkinsons Inst & Clin Ctr, Basic Res, Sunnyvale, CA USA Luxembourg Inst Sci & Technol, Environm Res & Innovat, Luxembourg, Luxembourg Univ Wollongong, Sch Comp & Informat Technol, Wollongong, NSW, Australia Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Bari, Italy Flinders Univ S Australia, Coll Nursing & Hlth Sci, Adelaide, SA, Australia Univ S Florida, Mol Med, Tampa, FL USA Univ Texas Dallas, Behav & Brain Sci, Richardson, TX 75083 USA Rhodes Univ, Zool & Entomol, Grahamstown, South Africa Univ Nova Lisboa, Inst Higiene & Med Trop, Lisbon, Portugal Swiss Fed Inst Technol, Inst Microbiol, Zurich, Switzerland Inst Ulm, German Red Cross Blood Serv, Immunohaematol, Ulm, Germany Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Tokyo, Japan Univ Limerick, Biol Sci, Limerick, Ireland McGill Univ, Dept Anim Sci, Montreal, PQ, Canada StatSol, Lubeck, Germany Univ KwaZulu Natal, Sch Math Stat & Comp Sci, Pietermaritzburg, South Africa Univ Kebangsaan Malaysia, Inst Syst Biol INBIOSIS, Bangi, Malaysia NIH, Natl Ctr Complementary & Integrat Hlth, Bldg 10, Bethesda, MD 20892 USA Univ Kansas, Med Ctr, Family Med Res Div, Kansas City, KS 66103 USA ASTAR, Inst Mol & Cell Biol, Multimodal Mol Biol, Singapore, Singapore Univ Leuven, Dept Chron Dis Metab & Ageing, Leuven, Belgium Int Iberian Nanotechnol Lab INL, Braga, Portugal Anglia Ruskin, Comp & Technol, Cambridge, England Max Planck Inst Biochem, Struct Cell Biol, Planegg, Germany Univ Seville, Dept Comp Architecture & Technol, Seville, Spain Univ Colorado, EBIO, Boulder, CO 80309 USA Univ Manchester, Canc Sci, Manchester, Lancs, England Australian Natl Univ, Res Sch Populat Hlth, Canberra, ACT, Australia Singapore MIT Alliance Res & Technol, Biosyst, Singapore, Singapore Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Musculoskeletal Hlth & Ageing Res Program, Melbourne, Vic, Australia Ruhr Univ Bochum, Gen Surg, St Josef Hosp, Bochum, Germany Northwest A&F Univ, Coll Life Sci, Xianyang, Shaanxi, Peoples R China Australian Natl Univ, Res Sch Biol, Div Plant Sci, Canberra, ACT, Australia Battelle Mem Inst, Clin & Nonclin Res, Columbus, OH USA Southern Methodist Univ, Biol Sci, Dallas, TX 75275 USA Teikyo Univ, Inst Med Mycol, Tokyo, Japan Tempus Labs, Bioinformat, Chicago, IL USA Hunan Univ, Coll Biol, Changsha, Hunan, Peoples R China Inst Cochin, Dept Infect Immun & Inflammat, Paris, France Royal Coll Surgeons Ireland, FutureNeuro Res Ctr Physiol & Med Phys, Dublin, Ireland Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland Heidelberg Univ, Dept Anesthesiol, Heidelberg, Germany Penn State Univ, Biol, University Pk, PA 16802 USA Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing, Peoples R China Univ Sci & Technol China, Sch Life Sci, Hefei, Anhui, Peoples R China Michigan State Univ, Anim Sci, E Lansing, MI 48824 USA SUNY Buffalo, Jacobs Sch Med & Biomed Sci, Dept Neurol, Buffalo Neuroimaging Anal Ctr, New York, NY USA Univ Rostock, Inst Biol Sci, Rostock, Germany South China Normal Univ, Sch Environm, Environm Res Inst, Guangzhou, Guangdong, Peoples R China Univ Bari, Dept Vet Med, Bari, Italy Radboud Univ Nijmegen, Med Ctr, Primary & Community Care, Nijmegen, Netherlands EcoHlth Alliance, New York, NY USA Mayo Clin, Cardiovasc Dept, Rochester, MN USA Med Univ Silesia, Sch Med Katowice, Dept Epidemiol, Katowice, Poland Univ Lleida, Anim Sci, Lleida, Spain Univ Florida, Coll Pharm, Pharmaceut Outcomes & Policy, Gainesville, FL USA Pacific Northwest Natl Lab, Earth & Biol Sci Directorate, Richland, WA 99352 USA Univ Edinburgh, Ctr Discovery Brain Sci, Edinburgh, Midlothian, Scotland Harvard Med Sch, Dept Biomed Informat, Boston, MA 02115 USA Univ Penn, Radiol, Philadelphia, PA 19104 USA Humanitas Univ & Res Hosp, Asthma & Allergy Unit, Biomed Sci Personalized Med, Rozzano, Italy Australian Natl Univ, Dept Quantum Sci, Canberra, ACT, Australia Carl von Ossietzky Univ Oldenburg, Ecol Genom, Oldenburg, Germany Int Med Univ, Paediat Dent & Orthodont, Kuala Lumpur, Malaysia Univ Ottawa, Sch Nursing, Ottawa, ON, Canada Maastricht Univ, Dept Educ Support, Maastricht, Netherlands Univ Manchester, Math, Manchester, Lancs, England Kings Coll London, Fac Life Sci & Med, Sch Populat Hlth Sci, London, England Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia Harbin Med Univ, Publ Hlth Sch, Epidemiol, Harbin, Heilongjiang, Peoples R China UiT Arctic Univ Norway, Dept Chem, Tromso, Norway Cornell Univ, Biol Stat & Computat Biol, Ithaca, NY USA East China Normal Univ, Sch Ecol & Environm Sci, Shanghai Key Lab Urban Ecol Proc & Ecorestorat, Shanghai, Peoples R China Johannes Gutenberg Univ Mainz, Fac Biol, Mainz, Germany Univ Massachusetts, Food Sci, Amherst, MA 01003 USA Max Planck Inst Terr Microbiol, Complex Adapt Traits Res Grp, Marburg, Germany NIHR Biomed Res Ctr Resp, Ctr Exercise & Rehabil Sci, Leicester, Leics, England Yale Univ, Dept Internal Med, Sect Endocrinol, New Haven, CT USA Sardar Patel Univ, Dept Biosci, Anand, Gujarat, India Univ Tokyo, Dept Appl Phys, Tokyo, Japan Univ Cologne, Vivo Res Facil ivRF, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany Natl Open Univ Nigeria, Dept Publ Hlth Sci, Lagos, Nigeria Univ Hosp Regensburg, Dept Radiol, Regensburg, Germany Natl Univ Singapore, Geog, Singapore, Singapore Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia Abdelmalek Essaadi Univ, Fac Sci & Techn Tangier, Biomed Genom & Oncogenet Res Lab, Tetouan, Morocco Tech Univ Munich, Fac Sport & Hlth Sci, Exercise Biol Grp, Munich, Germany Univ Santiago de Compostela, Dept Psicoloxia Social Basica & Metodoloxia, Galiza, Spain Griffith Univ, Signal Proc Lab, Brisbane, Qld, Australia Univ Ghent, Dept Neurol, Ghent, Belgium Ghent Univ Hosp, Ghent, Belgium Univ Ghent, Fac Vet Med, Merelbeke, Belgium Albert Einstein Coll Med, Inst Clin & Translat Res, New York, NY USA Anglia Ruskin Univ, Fac Med Sci, Cambridge, England Peking Univ, Coll Chem & Mol Engn, Beijing, Peoples R China Herlev & Gentofte Hosp, Dept Dermatol & Allergy, Hellerup, Denmark Lady Cilento Childrens Hosp, Med Imaging & Nucl Med, Brisbane, Qld, Australia Univ Gambia, Sch Med & Allied Hlth Sci, Nursing & Reprod Hlth, Brikama, Gambia Univ Sydney, Woolcock Inst Med Res, Sydney, NSW, Australia Wayne State Univ, Comp Sci, Detroit, MI USA Aberdeen Royal Infirm, Otolaryngol, Aberdeen, Scotland Univ Toronto, Lab Med & Pathobiol, Toronto, ON, Canada Chinese Univ Hong Kong, Inst Ageing, Hong Kong, Peoples R China Univ Nebraska Med Ctr, Emergency Med, Omaha, NE USA Univ Florida, Coll Med, Pathol, Gainesville, FL USA Univ Texas MD Anderson Canc Ctr, Radiat Oncol, Houston, TX 77030 USA Univ Pisa, Translat Res NTMS, Pisa, Italy Magna Grecia Univ, Clin & Expt Med, Catanzaro, Italy Univ Vermont, Larner Coll Med, Pediat, Burlington, VT USA Sun Yat Sen Univ, Canc Ctr, Diagnost & Intervent Ultrasound, Guangzhou, Guangdong, Peoples R China Fudan Univ, Inst Brain Sci, Shanghai, Peoples R China Shanxi Agr Univ, Coll Agron, Jinzhong, Shanxi, Peoples R China Univ Toronto, Inst Med Sci, Toronto, ON, Canada Univ Adelaide, ARCPOH, Adelaide, SA, Australia Pelita Harapan Univ, Fac Med, Cardiol & Vasc Med, Tangerang, Indonesia Inst Mental Hlth, Res Div, Singapore, Singapore UCL, MRC Clin Trials Unit, London, England Univ Padua, Dept Philosophy Sociol Educ & Appl Psychol FISPPA, Padua, Italy Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany Dalian Univ Technol, Ctr Mol Med, Dalian, Liaoning, Peoples R China Tianjin United Family Healthcare, Reprod Med, Tianjin, Peoples R China Univ Autonoma Barcelona, Dept Engn Quim Biol & Ambiental, Barcelona, Spain Sao Paulo State Univ UNESP, Dept Anim Sci, Sao Paulo, Brazil Helmholtz Zentrum Munchen, Inst Computat Biol, Canc Syst Biol, Ingolstadter Land Str 1, D-85764 Munich, Germany Univ Tokyo, Dept Cardiovasc Med, Tokyo, Japan Sao Paulo State Univ, Vet Clin, Sao Paulo, Brazil Zhejiang Univ, Inst Biotechnol, Hangzhou, Zhejiang, Peoples R China Aarhus Univ, Dept Mol Biol & Genet, Aarhus, Denmark Univ Manchester, St Marys Hosp, Maternal & Fetal Hlth, Manchester, Lancs, England Univ New Mexico, Internal Med, Albuquerque, NM 87131 USA Mayo Clin, Div Biomed Stat & Informat, Jacksonville, FL 32224 USA King Saud Univ, Plant Prod, Riyadh, Saudi Arabia Polish Acad Sci, Inst Genet & Anim Breeding, Dept Mol Biol, Warsaw, Poland Queensland Univ Technol, Optometry & Vis Sci, Brisbane, Qld, Australia Univ Nottingham, Sch Life Sci, Nottingham, England Canc Council Queensland, Canc Res Ctr, Brisbane, Qld, Australia Umea Univ, Dept Chem, Umea, Sweden Publ Hlth England, Ctr Radiat Chem & Environm Hazards, Bristol, Avon, England Univ Campania L Vanvitelli, DISTABIF, Caserta, Italy Bartshealth, Obstet & Gyanecol, London, England Univ Clermont Auvergne, GReD Lab, Clermont Ferrand, France INRA Abeilles & Environm, Avignon, France Queensland Univ Technol, Sch Publ Hlth & Social Work, Brisbane, Qld, Australia Univ Penn, Psychiat, Philadelphia, PA 19104 USA Novosibirsk State Univ, Res Inst Physiol & Basic Med, Novosibirsk, Russia UCL, Dept Chem, London, England La Trobe Univ, Anim Plant & Soil Sci, Melbourne, Vic, Australia Univ Arizona, Epidemiol & Biostat, Tucson, AZ USA Univ Groningen, Univ Med Ctr Groningen, ERIBA, Groningen, Netherlands Univ Gothenburg, Inst Clin Sci, Dept Radiat Phys, Gothenburg, Sweden SUNY Upstate Med Univ, Biochem & Mol Biol, Syracuse, NY 13210 USA Fundacao Oswaldo Cruz, Ctr Pesquisas Goncalo Moniz, Salvador, Bahia, Brazil Inst Environm Sci & Res ESR, Food Water & Environm Microbiol, Christchurch, New Zealand Univ Otago, Food Sci, Dunedin, New Zealand Florida Atlantic Univ, Biomed Sci, Boca Raton, FL 33431 USA Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia Univ Hosp Wurzburg, Inst Clin Neurobiol, Wurzburg, Germany Inst Trop Med, Publ Hlth, Antwerp, Belgium Univ Thessaly, Sch Hlth Sci, Fac Med, Dept Rheumatol & Clin Immunol, Larisa, Greece Univ Basel, UZB Univ Ctr Dent Med, Dept Orthodont & Pediat Dent, Basel, Switzerland Sorbonne Univ, Museum Natl Hist Nat, Inst Systemat Evolut Biodiversite ISYEB, MNHN,CNRS,UMR 7205,EPHE, Paris, France CNRS, Inst Adv Biosci, Paris, France Univ Western Australia, Sch Mol Sci, Perth, WA, Australia Univ Ft Hare, Biochem & Microbiol, Alice, South Africa Univ Tubingen, Phys, Tubingen, Germany Griffith Univ, Sch Environm & Sci, Brisbane, Qld, Australia Philosoph Theol Hsch Vallendar, Stat & Standardised Methods, Vallendar, Germany Imperial Coll London, Life Sci, London, England Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE USA Technol Univ Dublin, FOCAS Res Inst, Dublin, Ireland INSERM, Natl Inst Hlth & Med Res, Canc Res Ctr Toulouse, Paris, France Univ Santiago de Compostela, Dept Bioloxia Func, Grp BRAINSHARK, Galiza, Spain Univ Nebraska, Biol, Kearney, NE USA Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona, Spain Univ Pisa, Chem & Ind Chem, Pisa, Italy Univ Manchester, Wellcome Trust Ctr Cell Matrix Res, Manchester, Lancs, England Univ Montpellier, CNRS, Inst Human Genet, Montpellier, France Czech Acad Sci, Inst Organ Chem & Biochem, Prague, Czech Republic CSIC, Natl Ctr Biotechnol CNB, Computat Syst Biol Grp, Madrid, Spain Natl Cheng Kung Univ, Dept Biochem & Mol Biol, Tainan, Taiwan Harvard Med Sch, Schepens Eye Res Inst, Ophthalmol, Boston, MA 02115 USA Lanzhou Univ, Hosp 2, Dept Gen Surg, Lanzhou, Gansu, Peoples R China Univ Technol Sydney, Sch Life Sci, Sydney, NSW, Australia JT Chen Clin, Gynecol, Tokyo, Japan Univ Western Australia, Sch Agr & Environm, Perth, WA, Australia Beijing Normal Univ, Fac Geog Sci, Beijing, Peoples R China Univ Missouri, Elect Engn & Comp Sci, Columbia, MO USA Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam, Netherlands Semmelweis Univ, Med Biochem, Budapest, Hungary Queen Elizabeth Hosp, Dept Clin Oncol, Hong Kong, Peoples R China Univ Pittsburgh, Chem, Pittsburgh, PA USA GB Pant Inst Post Grad Med Educ & Res, Neurol, New Delhi, India Univ Copenhagen, Vet & Anim Sci, Copenhagen, Denmark Univ Palermo, Biomed Dept Internal & Specialist Med DIBIMIS, Sect Endocrinol, Palermo, Italy UCL, NPP, London, England Univ Florida, Microbiol & Cell Sci, Gainesville, FL USA Univ Salford, Sch Hlth Sci, Manchester, Lancs, England Cardiff Univ, Inst Med Genet, Cardiff, S Glam, Wales INSERM, ICO Canc Ctr, Angers, France Univ Colombo, Fac Med, Microbiol, Colombo, Sri Lanka Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China Univ Porto, Fac Pharm, Porto, Portugal Univ Nottingham, Div Primary Care, Nottingham, England Univ Illinois, Pharm Syst Outcomes & Policy, Chicago, IL USA Pontificia Univ Catolica Goias, Escola Ciencias Agr & Biol, Goiania, Go, Brazil China Japan Friendship Hosp, Dept Oncol, Beijing, Peoples R China Boston Univ, Chem, Boston, MA 02215 USA Amer Univ, Environm Sci, Washington, DC 20016 USA Carleton Univ, Neurosci, Ottawa, ON, Canada Univ Regina, Chem & Biochem, Regina, SK, Canada Univ Montreal, Microbiolgy, Montreal, PQ, Canada Univ Leicester, Dept Genet & Genome Biol, Leicester, Leics, England Univ Queensland, Sch Agr & Food Sci, Gatton, Qld, Australia CNRS, BIOM, Paris, France UCL, Hatter Cardiovasc Inst, London, England Flinders Univ S Australia, Sci & Engn, Adelaide, SA, Australia Univ Warwick, Engn, Coventry, W Midlands, England Katholieke Univ Leuven, Ctr Human Genet, Leuven, Belgium Fudan Univ, Dept Macromol Sci, Shanghai, Peoples R China Dokuz Eylul Univ, Biol Educ, Izmir, Turkey Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA Mondo Med, Pulm Dis, Borgomanero, Italy US Naval, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC USA Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway Peking Univ, Dept Mech & Engn Sci, Beijing, Peoples R China Saarland Univ, Dept Pharm Pharmaceut & Med Chem, Saarbrucken, Germany INSERM, Natl Inst Hlth & Med Res, Skin Res Inst, Paris, France Shanghai Proton & Heavy Ion Ctr, Res & Dev, Shanghai, Peoples R China Univ Georgia, Epidemiol, Athens, GA 30602 USA Univ Freiburg, Med Ctr, Dept Plast & Hand Surg, Freiburg, Germany Sidra Med, Res, Doha, Qatar Rostock Univ, Med Ctr, Dept Oral Maxillofacial & Plast Surg, Rostock, Germany Harvard Med Sch, Brigham & Womens Hosp, Emergency Med, Boston, MA 02115 USA AgResearch, Forage Sci, Palmerston North, New Zealand Univ Calif Los Angeles, Med, Los Angeles, CA USA Arizona State Univ, Biodesign Inst, Virginia G Piper Ctr Personalized Diagnost, Tempe, AZ USA Sheffield Hallam Univ, Res Inst, Mat & Engn, Sheffield, S Yorkshire, England Aneurin Bevan Univ Healthboard, Resp Med, Newport, Shrops, England Univ Calif San Francisco, Neurol Surg, San Francisco, CA 94143 USA Univ Western Australia, UWA Dent Sch, Perth, WA, Australia Fordham Univ, Biol Sci, Bronx, NY 10458 USA Univ Helsinki, Inst Biotechnol, Helsinki, Finland Fujian Normal Univ, Coll Life Sci, Fuzhou, Fujian, Peoples R China Univ Fukui, Dept Frontier Fiber Technol & Sci, Fukui, Japan Univ Southampton, Fac Med, Clin & Expt Sci, Southampton, Hants, England Univ Urbino, Dept Biomol Sci, Urbino, Italy Osped San Luigi, Allergol Unit, Turin, Italy Muljibhai Patel Urol Hosp, Dept Urol, Nadiad, Gujarat, India Univ Granada, Stratig & Paleontol, Granada, Spain Massey Univ, Sch Vet Sci, Auckland, New Zealand CNR, High Performance Comp & Networking Inst, Naples, Italy Univ Childrens Hosp Zurich, Div Metab, Zurich, Switzerland Univ Childrens Hosp Zurich, Childrens Res Ctr, Zurich, Switzerland Univ Melbourne, Biochem & Mol Biol, Parkville, Vic, Australia Inst Pasteur, Leptospirosis Res & Expertise Unit, Noumea, New Caledonia Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China Cheikh Anta Diop Univ UCAD, Sci Fac, Biol Anim Dept, Dakar, Senegal Providence Portland Med Ctr, Earle A Chiles Res Inst, Portland, OR USA Agr & Agri Food Canada, Lacombe Res & Dev Ctr, Lacombe, AB, Canada Alberta Innovates, Performance Management & Evaluat, Edmonton, AB, Canada Univ Malaga, CSIC, Inst Hortofruticultura Subtrop Mediterranea La Ma, IHSM,UMA, Malaga, Spain James Cook Univ, Coll Publ Hlth Med & Vet Sci, Cairns, Qld, Australia European Commiss, Joint Res Ctr, Ispra, Italy Univ Montpellier, Montpellier, France CSIRO, Floreat, WA, Australia Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Guangdong, Peoples R China Vanderbilt Univ, Pharmacol, 221 Kirkland Hall, Nashville, TN 37235 USA RIKEN, KFU RIKEN Translat Genom Unit, Yokohama, Kanagawa, Japan Univ Tubingen, Neurobiol Vocal Commun, Tubingen, Germany Univ Colorado, UCCS Ctr Biofrontiers Inst, Colorado Springs, CO 80907 USA Fred Hutchinson Canc Ctr, Div Basic Sci, Seattle, WA USA Univ Geneva, Fac Med, Primary Care Unit, Geneva, Switzerland Ernst Moritz Arndt Univ Greifswald, Dept Mol Genet & Infect Biol, Greifswald, Germany East China Univ Sci & Technol, Dept Fine Chem, Shanghai, Peoples R China Ohio State Univ, Surg, Columbus, OH 43210 USA Oragenics, R&D, Tampa, FL USA Natl Environm Agcy, Environm Hlth Inst, Singapore, Singapore Friedrich Loeffler Inst, Inst Diagnost Virol, Greifswald, Germany Queen Elizabeth Hosp, Oncol, Woodville, SA, Australia USDA, Emerging Pests & Pathogens Res Unit, Ithaca, NY USA Univ Freiburg, Med Ctr, Dept Neurosurg, Epilepsy Ctr, Freiburg, Germany Univ Hong Kong, Fac Educ, Informat & Technol Studies, Hong Kong, Peoples R China Univ Tokyo, Grad Sch Agr & life Sci, Agr & Environm Biol, Tokyo, Japan Univ Pittsburgh, Dept Med, Pittsburgh Heart Lung & Blood Vasc Med Inst, Pittsburgh, PA USA Guys & St Thomas NHS Fdn Trust, Directorate Transplant Renal & Urol, London, England Univ Sarajevo, Clin Ctr, Clin Heart Blood Vessel & Rheumat Dis, Sarajevo, Bosnia & Herceg Univ Kent, Sch Math Stat & Actuarial Sci, Canterbury, Kent, England Tokyo Inst Technol, Dept Life Sci & Technol, Tokyo, Japan Univ Appl Sci Munich, Laser Ctr Dept Appl Sci & Mechatron, Munich, Germany CIC NanoGUNE, Nanodevices, San Sebastian, Spain Vrije Univ Amsterdam Med Ctr, Gynaecol, Amsterdam, Netherlands Cardiff Univ, Med Sch, Div Populat Med, Cardiff, S Glam, Wales Karolinska Inst, Dept Med, Solna, Sweden Natl Inst Genet, Ctr Informat Biol, Mishima, Shizuoka, Japan Murdoch Univ, Harry Perkins Inst Med Res, Perth, WA, Australia Univ Limerick, Phys Educ & Sport Sci, Limerick, Ireland Ruhr Univ Bochum, Campus Clin Gynecol, Univ Str, Bochum, Germany Southwest Med Univ, Sch Publ Hlth, Epidemiol & Biostat, Luzhou, Sichuan, Peoples R China Beijing Canc Hosp, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Ctr Mol Diagnost, Beijing, Peoples R China Chinese Acad Sci, Chengdu Inst Biol, Herpetol Dept, Chengdu, Sichuan, Peoples R China Key Lab Nano Biol Effects & Safety, Beijing, Peoples R China NIBR, PK Sci, Basel, Switzerland Daejeon St Marys Hosp, Pain Ctr, Daejeon, South Korea Univ Western Ontario, Sch Hlth Studies, London, ON, Canada Univ Aberdeen, Hlth Psychol Grp, Aberdeen, Scotland Univ Colorado, Anesthesiol, Anschutz Med Campus, Boulder, CO 80309 USA Univ Antwerp, UZA Antwerp Univ Hosp, Crit 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Univ Calif Los Angeles, Sch Dent, Sect Periodont, Los Angeles, CA 90024 USA Aalborg Univ Hosp, Dept Clin Biochem, Aalborg, Denmark Manipal Acad Higher Educ, Pharm Practice, Manipal, Karnataka, India Univ Tokyo, Inst Med Sci, Dept Radiol, Tokyo, Japan Cukurova Univ, Family Med, Fac Med, Adana, Turkey Catholic Univ Korea, Coll Med, Dept Humanities & Social Med, Seoul, South Korea Univ Ghent, Food Technol Safety & Hlth, Ghent, Belgium UNSW Sydney, Sch Biol Earth & Environm Sci BEES, Sydney, NSW, Australia St Vincent Shoulder & Sports Clin, Res Unit, Vienna, Austria Cornell Univ, Biomed Engn, Ithaca, NY USA Leibniz Inst Plant Genet & Crop Plant Res IPK, Res Grp Bioinformat & Informat Technol, Gatersleben, Germany Univ Europea Madrid, Sch Doctoral Studies, Madrid, Spain CSIRO Mfg, Biomed Mfg, Melbourne, Vic, Australia Depaul Univ, Biol Sci, Chicago, IL 60604 USA Konkuk Univ, Dept Anim Sci & Technol, Seoul, South Korea Chang Gung Univ, Grad Inst Med Mechatron, Taoyuan, Taiwan Korea Univ, 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Biochem & Mol Biol, 1430 Tulane Ave, New Orleans, LA 70112 USA NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA NIH, NCBI, Natl Lib Med, Bldg 10, Bethesda, MD 20892 USA LOreal Res & Innovat, Aulnay Sous Bois, France Lund Univ, Dept Psychol, Malmo, Sweden Catholic Univ Louvain, Inst Rech Expt & Clin, Brussels, Belgium Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA Univ Melbourne, Ophthalmol, Surg, Parkville, Vic, Australia Univ Western Australia, Ctr Ophthalmol & Visual Sci, Perth, WA, Australia Iran Univ Med Sci, Med Phys, Fac Med, Tehran, Iran Salk Inst Biol Studies, Cellular Neurobiol, La Jolla, CA USA Imperial Coll London, Fibrosis Res Grp, London, England Univ Texas MD Anderson Canc Ctr, Genitourinary Med Oncol, Houston, TX 77030 USA Univ Liege, GIGA Neurosci, Liege, Belgium Univ Crete, Sch Med, Urol, Iraklion, Greece Flinders Univ S Australia, Flinders Med Ctr, Dept Clin Pharmacol, Adelaide, SA, Australia Max Planck Inst Immunobiol & Epigenet, Bioinformat, Breisgau, Germany Cardiff Univ, Sch Psychol, Cardiff, S Glam, Wales Imperial Coll London, Chem Engn, London, England Lund Univ, Skane Univ Hosp, Clin Sci, Malmo, Sweden Sahlgrens Acad, Inst Clin Sci, Dept Mol & Clin Med, Gothenburg, Sweden Univ Cent Lancashire, Sch Pharm & Biomed Sci, Preston, Lancs, England Hosp Univ Doctor Peset, Psychiat & Clin Psychol, Valencia, Spain Ctr Biol Mol Severo Ochoa, Genome Dynam & Funct, Madrid, Spain Unvivers Hosp Lille, Dept Intens Care, Lille, France Kansai Med Univ, Surg, Osaka, Japan Univ Toulouse, Inst Natl Polytech Toulouse, Ecole Natl Super Agron Toulouse, Lab Genom & Biotechnol Fruit, Toulouse, France UiT Arctic Univ Norway, Inst Psychol, Tromsto, Norway Queens Univ, Ctr Publ Hlth, Belfast, Antrim, North Ireland Univ Manchester, Ctr Primary Care & Hlth Serv Res, Manchester, Lancs, England Griffith Univ, Menzies Hlth Inst, Gold Coast, Qld, Australia Anglia Ruskin Univ, FHSCE, Cambridge, England Univ Lleida, Dept Expt Med, Lleida, Spain NIEHS, Biomol 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Phys & Mech Engn, Brisbane, Qld, Australia Otto von Guericke Univ, Psychol, Magdeburg, Germany Univ Med Ctr Gottingen, Dept Expt Neurodegenerat, Gottingen, Germany Harvard Med Sch, Spaulding Rehabil Hosp, Phys Med & Rehabil, Boston, MA 02115 USA Quadram Inst Biosci, Sci Operat, Norwich, Norfolk, England Ostbayer Tech Hsch Regensburg OTH Regensburg, Regensburg Med Image Comp ReMIC, Regensburg, Germany Deakin Univ, Fac Arts & Educ, Melbourne, Vic, Australia Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England INSERM, Natl Inst Hlth & Med Res, Biochem & Mol Biol, Paris, France Univ Liege, Tax Inst, Liege, Belgium Univ Leeds, Sch Mol & Cellular Biol, Leeds, W Yorkshire, England IRCCS Ist Giannina Gaslini, UOC Genet Med, Genoa, Italy Res Diets Inc, Sci, New Brunswick, NJ USA Univ Perugia, Dept Phys & Geol, Perugia, Italy Walter Reed Natl Mil Med Ctr, Cellular Immunol, Bethesda, MD USA Univ Fed Santa Catarina, Biol Sci Ctr, Microbiol Immunol & Parasitol Dept, Florianopolis, SC, Brazil Univ Edinburgh, Royal Infirm, Ctr Liver & Digest Disorders, Edinburgh, Midlothian, Scotland Orion Pharma, Crit Care Proprietary Prod Div, Espoo, Finland MIT, Dept Civil & Environm Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA Univ Turin, Dept Vet Sci, Turin, Italy Univ G dAnnunzio, Dept Psychol Hlth & Territorial Sci, Chieti, Italy NYU, Sch Med, OB GYN, New York, NY USA Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland Univ Turku, Dept Biol, Turku, Finland Tech Univ Berlin, Bioanalyt, Berlin, Germany Univ Goettingen, Inst Phys Biophys 3, Gottingen, Germany Univ Texas MD Anderson Canc Ctr, Inst Appl Canc Sci, Translat Res Adv Therapeut & Innovat Oncol TRACTI, Houston, TX 77030 USA Univ Liege, Life Sci, Liege, Belgium Tarbiat Modares Univ, Fac Med Sci, Dept Toxicol, Tehran, Iran ARS, USDA, Stoneville, MS USA Univ Regensburg, RCI Regensburg Ctr Intervent Immunol, Regensburg, Germany Univ Nottingham, Sch Psychol, Nottingham, England NIH, Pathol Lab, Bethesda, MD 20892 USA Univ Carlos III Madrid, Elect Engn, Madrid, Spain Inst Med Mol, Chem Biol, Lisbon, Portugal Univ Costa Rica, CIET, San Jose, Costa Rica Univ Stavanger, Fac Hlth Sci, Stavanger, Norway Erasmus MC, Urol, Rotterdam, Netherlands Univ Edinburgh, Sch Biol Sci, Edinburgh, Midlothian, Scotland German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol IBIS, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany Leiden Univ, Huygens Kamerlingh Onnes Lab, Leiden, Netherlands Univ Vienna, Nutr Sci, Vienna, Austria Kolling Inst Med Res, Med, St Leonards, NSW, Australia Johns Hopkins Sch Med, Biol Chem, Baltimore, MD USA Univ Montreal, Med Nutr & Microbiome Lab, Montreal, PQ, Canada GlaxoSmithKline, Cell & Gene Therapy, Stevenage, Herts, England Univ Trieste, Life Sci, Trieste, Italy Rhein Westfal TH Aachen, Dept Radiol, Aachen, Germany Univ Duisburg Essen, Univ Hosp Essen, West German Canc Ctr, Dept Med Oncol, Essen, Germany Med Univ Vienna, Obstet & Gynecol, Vienna, Austria FHI 360, Social & Behav Hlth Sci Div, Washington, DC USA KU Leuven VIB, Switch Lab, Leuven, Belgium Bielefeld Univ, Fac Technol, Bielefeld, Germany Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Nutr, Dept Gastrointestinal Surg, Beijing, Peoples R China Meiji Univ, Dept Agr Chem, Kawasaki, Japan Yonsei Univ, Coll Med, Microbiol, Seoul, South Korea Johnson & Johnson EAME, Maidenhead, Berks, England Penn State Coll Med, Pediat, Hershey, PA USA Univ N Carolina, Dept Social Med, Chapel Hill, NC 27515 USA Univ Western Australia, ARC CoE Plant Energy Biol, Perth, WA, Australia Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands Kings Coll London, Dept Neuroimaging, London, England Univ Murcia, Biochem & Mol Biol, Murcia, Spain Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA Monash Univ, Biochem & Mol Biol, Melbourne, Vic, Australia Chinese Acad Sci, Inst Genet & Dev Biol, Beijing, Peoples R China Univ Pittsburgh, Pharmacol & Chem Biol, Pittsburgh, PA USA Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland Univ Queensland, Sch Pharm, Brisbane, Qld, Australia Leibniz Inst Plant Genet & Crop Plant Res IPK Gat, Genebank, Gatersleben, Germany Piramal Imaging, Res & Dev, Berlin, Germany Univ Leeds, Civil Engn, Leeds, W Yorkshire, England Univ Missouri, Chem & Biochem, St Louis, MO 63121 USA US Geol Survey, Coastal & Marine Geol Program, Pacific Coastal & Marine Sci Ctr, Santa Cruz, CA USA Ajinomoto Genet Res Inst, Moscow, Russia Jagiellonian Univ, Fac Biochem Biophys & Biotechnol, Dept Plant Biotechnol, Krakow, Poland Univ Puerto Rico, Engn Sci & Mat, Mayaguez, PR USA Univ Regina, Dept Chem & Biochem, Regina, SK, Canada Argonne Natl Lab, Ctr Nanoscale Mat, 9700 S Cass Ave, Argonne, IL 60439 USA Univ Sunshine Coast, Sunshine Coast Mind & Neurosci Thompson Inst, Sippy Downs, Qld, Australia Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Beijing, Peoples R China Griffith Univ, Griffith Ctr Social & 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Maximilians Univ Munchen, Phys Chem, NanoBioSci, Munich, Germany Bandung Inst Technol, Sch Pharm, Med Chem, Bandung, Indonesia Univ Luxembourg, Life Sci Res Unit, Luxembourg, Luxembourg Lund Univ, Skane Univ Hosp, Dept Gastroenterol, Malmo, Sweden Millennium Hlth, Translat Genet, San Diego, CA USA Aristotle Univ Thessaloniki, Med Dept 2, Clin Res & Evidence Based Med Unit, Thessaloniki, Greece Jan Kochanowski Univ Humanities & Sci, Piotrkow Trybunalski Branch, Dept Psychol, Kielce, Poland McMaster Univ, Engn Phys, Hamilton, ON, Canada Marche Polytech Univ, Dept Agr Food & Environm Sci, Ancona, Italy Kuwait Univ, Fac Med, Microbiol, Kuwait, Kuwait Fujita Hlth Univ, Dept Breast Surg, Toyoake, Aich, Japan North West Reg Spinal Injuries Ctr, Spinal Injuries Ctr, Southport, Merseyside, England Luxembourg Inst Hlth, Competence Ctr Methodol & Stat, Luxembourg, Luxembourg Nestle Inst Hlth Sci SA, Metab Hlth, Ecublens, Vaud, Switzerland Ctr Inflammat Res VIB, Ghent, Belgium Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium Univ Lisbon, Inst Educ, Curriculo Formacao Prof & Tecnol, Lisbon, Portugal Univ Edinburgh, Ctr Inflammat Res, Edinburgh, Midlothian, Scotland Univ Melbourne, Sch BioSci, Parkville, Vic, Australia Northumbria Univ, Comp & Informat Sci, Newcastle Upon Tyne, Tyne & Wear, England Univ Valencia, Endocrinol, Valencia, Spain INRS, Inst Armand Frappier, Laval, PQ, Canada Univ Laval, INAF, Sch Nutr, Quebec City, PQ, Canada Univ Konstanz, Dept Biol, Constance, Germany Univ Cote dAzur, LAMHESS, Nice, France Scion, Syst Ecol, Christchurch, New Zealand CUNY, Grad Sch Publ Hlth & Hlth Policy, Epidemiol & Biostat, New York, NY 10021 USA Univ Queensland, Sch Dent, Brisbane, Qld, Australia George Inst Global Hlth, Renal & Metab Div, Sydney, NSW, Australia Wuhan Univ, Coll Chem & Mol Sci, Wuhan, Hubei, Peoples R China Griffith Univ, Sch Environm & Sci, Gold Coast, Qld, Australia Univ Minnesota, Radiat Oncol, Minneapolis, MN USA Goethe Univ, Fac Med, Frankfurt, Germany Natl Yunlin Univ Sci & Technol, Dept & Grad Sch Safety & Environm Engn, Touliu, Yunlin, Taiwan Massey Univ, Sch Sport Exercise & Nutr, Auckland, New Zealand Univ Florida, Wildlife Ecol & Conservat, Gainesville, FL USA Bournemouth Univ, Dept Psychol, Poole, Dorset, England Robert Koch Inst, Project Grp P2, Berlin, Germany Univ Edinburgh, MRC Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland Univ Basel, Biozentrum, Basel, Switzerland Univ Wollongong, Sch Med, Wollongong, NSW, Australia Univ Cologne, Inst Human Genet, Cologne, Germany Rural Econ Branch, Econ Res Serv, Washington, DC USA Uivers Bordeaux, CNRS, Inst Neurosci Cognit & Integrat Aquitaine, Bordeaux, France Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA Univ Calif Riverside, Mat Sci & Engn Program, Riverside, CA 92521 USA Mackay Med Coll, Dept Med, New Taipei, Taiwan Univ Bern, Div Anim Welf, Bern, Switzerland Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Med Sci, Shanghai, Peoples R China McMaster Univ, Biol, Hamilton, ON, Canada Univ S Florida, Dept Cell Biol Microbiol & Mol Biol, Tampa, FL USA Hacettepe Univ, Inst Canc, Med Oncol, Ankara, Turkey City Univ Hong Kong, Dept Elect Engn, Hong Kong, Peoples R China Natl Taiwan Univ, Dept Entomol, Taipei, Taiwan Chinese Acad Agr Sci, Inst Environm & Sustainable Dev Agr, Ecol Secur, Beijing, Peoples R China Florida State Univ, Inst Mol Biophys, Chem & Biochem, Tallahassee, FL USA Peking Univ, Shenzhen Grad Sch, State Key Lab Chem Oncogen, Lab Computat Chem & Drug Design, Shenzhen, Peoples R China Univ Helsinki, Fac Pharm, Div Pharmaceut Chem & Technol, Drug Res Program, Helsinki, Finland Tohoku Univ, Microbial Biotechnol, Sendai, Miyagi, Japan Tianjin Med Univ, Sch Basical Med Sci, Dept Pharmacol, Tianjin, Peoples R China Dana Farber Canc Inst, Biostat & Computat Biol, Boston, MA 02115 USA Natl Hlth Res Inst, Inst Mol & Genom Med, Zhunan, Taiwan Univ Oxford, Physiol Anat & Genet, Oxford, England George Washington Univ, Phys, Washington, DC USA Univ Nebraska, Sch Biol Sci, Lincoln, NE USA Toronto Gen Hosp, Res Inst, Dept Lab Med & Pathobiol, Toronto, ON, Canada Univ Texas Dallas, Biol Sci, Richardson, TX 75083 USA NYU, Dept Chem, New York, NY USA Shandong Univ, Sch Math & Stat, Jinan, Shandong, Peoples R China Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei, Anhui, Peoples R China Purdue Univ, Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA NIBSC, Adv Therapies, Ridge, Herts, England Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Pulm & Crit Care Med, Shanghai, Peoples R China Charite Med Univ Berlin, Dermatol & Allergy, Berlin, Germany Univ Hosp St Etienne, Hematol, St Etienne, France Inland Norway Univ Appl Sci, Inst Biotechnol, Elverum, Norway Univ Jordan, Pediat, Amman, Jordan Inst Pasteur, Mol Mycol Unit, Paris, France Cardiff Univ, Sch Med, Inst Psychol Med & Clin Neurosci, Med Res Council Ctr Neuropsychiat Genet & Genom, Cardiff, S Glam, Wales Zurich Univ Appl Sci, Social Work, Zurich, Switzerland Jawaharlal Nehru Univ, Sch Life Sci, New Delhi, India Univ Burgundy Franche Comte, LE2I, Dijon, France Univ Roehampton, Life Sci, London, England Ghent Univ Hosp, Gen & HPB Surg, Ghent, Belgium Univ Wurzburg, Insect Fungus Symbiosis Lab, Wurzburg, Germany Radboud Univ Nijmegen, Behav Sci Inst, Nijmegen, Netherlands Fraunhofer WKI, Applicat Ctr HOFZET, Hannover, Germany UCL, Struct & Mol Biol, London, England Univ Amsterdam, Dev Psychol, Amsterdam, Netherlands Aalborg Univ, Hlth Sci & Technol, CNAP, SMI, Aalborg, Denmark VA Pittsburgh Healthcare Syst, Ctr Hlth Equity Res & Promot, Pittsburgh, PA USA Cedars Sinai Med Ctr, Neurosurg, Los Angeles, CA 90048 USA Sun Yat Sen Univ, Sch Data & Comp Sci, Guangzhou, Guangdong, Peoples R China Dezhou Univ, Shandong Prov Key Lab Biophys, Guangzhou, Guangdong, Peoples R China Maison Teledetection, Inst Rech Dev, UMR Espace DEv, Montpellier, France Xiamen Univ, Sch Life Sci, Xiamen, Fujian, Peoples R China Nanjing Univ, Sch Med, Jinling Hosp, Natl Clin Res Ctr Kidney Dis,Dept Med Imaging, Nanjing, Jiangsu, Peoples R China Univ Kent, Sch Social Policy Sociol & Social Res, Canterbury, Kent, England Univ Fed Minas Gerais, Infect Dis & Trop Med, Belo Horizonte, MG, Brazil Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Braga, Portugal Univ Montreal, Biochim & Med Mol, Montreal, PQ, Canada Johns Hopkins Bloomberg Sch Publ Hlth, Epidemiol, Baltimore, MD USA Max Planck Inst Biol Ageing, Metab & Genet Regulat Ageing, Cologne, Germany Univ Swaziland, Hlth Sci, Kwaluseni, Eswatini Queensland Univ Technol, Inst Future Environm, Brisbane, Qld, Australia Ctr Sci Monaco, Dept Biol Med, Monaco, Monaco HELIOS Hosp, Urol, Bad Saarow Pieskow, Germany Tech Univ Carolo Wilhelmina Braunschweig, Inst Microbiol, Braunschweig, Germany Univ Barcelona, Barcelona Ctr Maternal Fetal & Neonatal Med, Fetal i D Fetal Med Res Ctr, IDIBAPS BCNatal,Hosp Clin, Barcelona, Spain Univ Barcelona, Hosp St Joan de Deu, Barcelona, Spain Friedrich Loeffler Inst, Inst Bacterial Infect & Zoonoses, Jena, Germany Charite Med Univ Berlin, Neurol, Berlin, Germany Dublin City Univ, Natl Inst Cellular Biotechnol, Mol Therapeut Canc Ireland, Dublin, Ireland Schoen Clin Roseneck, Prien Am Chiemsee, Germany Univ Med Ctr Hamburg Eppendorf, Inst Sex Res & Forens Psychiat, Hamburg, Germany Nankai Univ, Sch Math Sci, Tianjin, Peoples R China Nankai Univ, LPMC, Tianjin, Peoples R China Univ Oxford, Oncol, Oxford, England Royal Holloway Univ London, Class, Egham, Surrey, England Cornell Univ, Clin Sci, Ithaca, NY USA Univ KwaZulu Natal, Pharmaceut Chem, Westville Campus, Durban, South Africa Royal Coll Surgeons Ireland, Med, Dublin, Ireland Univ Oslo, Dept Immunol, Oslo, Norway Bermuda Inst Ocean Sci, Marine Nitrogen Cycling Lab, St Georges, Bermuda Kanazawa Univ, Inst Liberal Arts & Sci, Kanazawa, Ishikawa, Japan World Hlth Org Reg Off Africa, 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Infect Treatment & Prevent, St Petersburg, Russia Hangzhou Ctr Dis Control & Prevent, Dept TB Control & Prevent, Hangzhou, Zhejiang, Peoples R China Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung, Taiwan Zoetis, Diagnost, Kalamazoo, MI USA Aintree Univ Hosp NHS Fdn Trust, Head & Neck Oncol Res, Liverpool, Merseyside, England Wrightington Hosp, Trauma & Orthopaed, Manchester, Lancs, England Loyola Univ, Med Ctr, Dept Psychiat, 2160 S 1st Ave, Maywood, IL 60153 USA Atkins Vet Serv, Microbiol, Calgary, AB, Canada Univ Porto, FADEUP, CIAFEL, Porto, Portugal Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore Kangwon Natl Univ, Coll Biotechnol & Biosci, Dept Food Sci & Biotechnol, Chunchon, South Korea Kakatiya Med Coll, Internal Med, Warangal, Telangana, India Univ Antioquia, Vet Med Sch, CIBAV Res Grp, Medellin, Colombia IISER, Dept Phys, Soft & Act Matter Grp, Tirupati 517507, Andhra Pradesh, India Univ Rosario, Sch Med & Hlth, Ctr Studies Phys Activ Measurements, 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Informat Engn, Xiangtan, Hunan, Peoples R China Univ Hlth Network, Mood Disorders & Psychopharmacol, Toronto, ON, Canada Sao Paulo State Univ UNESP, Dept Anim Sci, Sao Paulo, Brazil Sao Paulo State Univ, Vet Clin, Sao Paulo, Brazil

Published
2019
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21. The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

Author

Alexander Kapp, Torsten Zuberbier, Zenon Brzoza, Jacques Hébert, A H Abdul Latiff, Elias Toubi, Werner Aberer, Mario Sánchez-Borges, Giorgio Walter Canonica, Bettina Wedi, Clive Grattan, Gordon Sussman, Gino A. Vena, Michihiro Hide, Alexander Nast, Carsten Bindslev-Jensen, P. Mathelier-Fusade, Petra Staubach, Luis Felipe Ensina, Martin K. Church, Martin Metz, Riccardo Asero, Ana Giménez-Arnau, Peter Schmid-Grendelmeier, Kiran Godse, X J Zhu, Margarida Gonçalo, Allen P. Kaplan, Markus Maurer, Sarbjit S. Saini, F. E. R. Simons, University of Zurich, Zuberbier, T, Charite, Med Univ Graz, Clin San Carlo, Univ Southern Denmark, Med Univ Silesia, Univ Genoa, Universidade Federal de São Paulo (UNIFESP), Univ Autonoma Barcelona, Dr DY Patil Med Coll & Hosp, Fac Med, Univ Hosp, Guys & St Thomas Hosp NHS Fdn Trust, Ctr Appl Res Allergy Quebec, Hiroshima Univ, Med Univ S Carolina, Hannover Med Sch, Pantai Hosp Kuala Lumpur, Univ Hosp Tenon, Johns Hopkins Asthma & Allergy Ctr, Ctr Medicodocente Trinidad, Univ Manitoba, Univ Med Ctr Mainz, Univ Toronto, Technion, Univ Bari, and Peking Univ

Subjects
Allergy, medicine.medical_specialty, hives, Immunology, lcsh:Medicine, 610 Medicine & health, Dermatology, Disease, urticaria, immune system diseases, lcsh:Dermatology, Humans, Immunology and Allergy, Medicine, media_common.cataloged_instance, European union, skin and connective tissue diseases, wheal, Asthma, media_common, 2403 Immunology, Acute urticaria, Angioedema, business.industry, angioedema, lcsh:R, Consensus conference, consensus, Urticaria, 10177 Dermatology Clinic, Guideline, lcsh:RL1-803, angioedema consensus hives urticaria wheal CHRONIC IDIOPATHIC URTICARIA QUALITY-OF-LIFE SERUM SKIN-TEST DELAYED PRESSURE URTICARIA DOSE INTRAVENOUS IMMUNOGLOBULIN ANTIIMMUNOGLOBULIN-E THERAPY RESISTANT CHRONIC URTICARIA RANDOMIZED CONTROLLED-TRIAL ULTRAVIOLET-B PHOTOTHERAPY WORLD-HEALTH-ORGANIZATION, medicine.disease, Systematic review, Family medicine, 2723 Immunology and Allergy, medicine.symptom, business
Abstract

This guideline is the result of a systematic literature review using the 'Grading of Recommendations Assessment, Development and Evaluation' (GRADE) methodology and a structured consensus conference held on 28 and 29 November 2012, in Berlin. It is a joint initiative of the Dermatology Section of the European Academy of Allergy and Clinical Immunology (EAACI), the EU-funded network of excellence, the Global Allergy and Asthma European Network (GA(2)LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of delegates of 21 national and international societies. Urticaria is a frequent, mast cell-driven disease, presenting with wheals, angioedema, or both. the life-time prevalence for acute urticaria is approximately 20%. Chronic spontaneous urticaria and other chronic forms of urticaria do not only cause a decrease in quality of life, but also affect performance at work and school and, as such, are members of the group of severe allergic diseases. This guideline covers the definition and classification of urticaria, taking into account the recent progress in identifying its causes, eliciting factors and pathomechanisms. in addition, it outlines evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Charite, Allergy Ctr Charite, Dept Dermatol & Allergy, D-10117 Berlin, Germany Med Univ Graz, Dept Dermatol, Graz, Austria Clin San Carlo, Allergy Clin, Paderno Dugnano, MI, Italy Univ Southern Denmark, Odense Univ Hosp, Dept Dermatol & Allergy Ctr, Odense, Denmark Med Univ Silesia, Allergol & Clin Immunol Katowice, Dept Internal Dis, Zabrze, Poland Univ Genoa, IRCCS AOU SanMartino, Genoa, Italy Universidade Federal de São Paulo, Dept Clin Immunol & Allergy, São Paulo, Brazil Univ Autonoma Barcelona, Hosp Mar Parc Salut Mar, E-08193 Barcelona, Spain Dr DY Patil Med Coll & Hosp, Dept Dermatol, Navi Mumbai, India Fac Med, Dermatol Clin, Coimbra, Portugal Univ Hosp, Coimbra, Portugal Guys & St Thomas Hosp NHS Fdn Trust, St Johns Inst Dermatol, London, England Ctr Appl Res Allergy Quebec, Quebec City, PQ, Canada Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Dermatol, Hiroshima, Japan Med Univ S Carolina, Dept Med, Div Pulm & Crit Care Med, Charleston, SC USA Hannover Med Sch, Dept Dermatol & Allergy, Hannover, Germany Pantai Hosp Kuala Lumpur, Dept Paediat, Kuala Lumpur, Malaysia Univ Hosp Tenon, Dept Dermatol & Allergy, Paris, France Johns Hopkins Asthma & Allergy Ctr, Baltimore, MD USA Ctr Medicodocente Trinidad, Allergy & Clin Immunol Dept, Caracas, Venezuela Univ Hosp, Dept Dermatol, Allergy Unit, Zurich, Switzerland Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB R3T 2N2, Canada Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada Univ Med Ctr Mainz, Dept Dermatol, Mainz, Germany Univ Toronto, Div Allergy & Clin Immunol, Toronto, ON, Canada Technion, Fac Med, Bnai Zion Med Ctr, Haifa, Israel Univ Bari, Dept Biomed Sci & Human Oncol, Unit Dermatol & Venereol, Bari, Italy Peking Univ, Hosp 1, Dept Dermatol, Beijing 100871, Peoples R China Universidade Federal de São Paulo, Dept Clin Immunol & Allergy, São Paulo, Brazil Web of Science

Published
2014
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22. Methods report on the development of the 2013 revision and update of the EAACI/GA2 LEN/EDF/WAO guideline for the definition, classification, diagnosis, and management of urticaria

Author

Markus Maurer, Alexander Nast, Mario Sánchez-Borges, Allen P. Kaplan, Riccardo Asero, Sarbjit S. Saini, F. E. R. Simons, P. Mathelier-Fusade, Petra Staubach, Luis Felipe Ensina, Torsten Zuberbier, A H Abdul Latiff, Carsten Bindslev-Jensen, Martin Metz, Alexander Kapp, Kiran Godse, Elias Toubi, G.W. Canonica, Clive Grattan, Gordon Sussman, Bettina Wedi, Werner Aberer, X J Zhu, Jean-Louis Hébert, Gino A. Vena, Peter Schmid-Grendelmeier, Martin K. Church, A. Giménez-Arnau, Margarida Gonçalo, Zenon Brzoza, Michihiro Hide, Charite, Med Univ Graz, Clin San Carlo, Odense Univ Hosp, Univ Southern Denmark, Med Univ Silesia, Univ Genoa, Universidade Federal de São Paulo (UNIFESP), Univ Autonoma Barcelona, Dr DY Patil Med Coll & Hosp, Fac Med, Univ Hosp, Guys & St Thomas Hosp NHS Fdn Trust, Ctr Appl Res Allergy Quebec, Hiroshima Univ, Med Univ S Carolina, Hannover Med Sch, Pantai Hosp Kuala Lumpur, Univ Hosp Tenon, Johns Hopkins Asthma & Allergy Ctr, Ctr Medicodocente Trinidad, Univ Manitoba, Univ Med Ctr Mainz, Univ Toronto, Technion, Univ Bari, University of Zurich, and Zuberbier, T

Subjects
medicine.medical_specialty, Pathology, Urticaria, hives, diagnosis, Immunology, Alternative medicine, 610 Medicine & health, medicine, Immunology and Allergy, Network of excellence, media_common.cataloged_instance, Humans, Guideline development, European union, Grading (education), wheal, media_common, 2403 Immunology, Evidence-Based Medicine, business.industry, angioedema, Consensus conference, 10177 Dermatology Clinic, Guideline, consensus, Systematic review, Family medicine, 2723 Immunology and Allergy, business
Abstract

GA2LEN EAACI This methods report describes the process of guideline development in detail. It is the result of a systematic literature review using the 'Grading of Recommendations Assessment, Development and Evaluation' (GRADE) methodology and a structured consensus conference held on 28 and 29 November 2012, in Berlin. It is a joint initiative of the Dermatology Section of the European Academy of Allergy and Clinical Immunology (EAACI), the EU-funded network of excellence, the Global Allergy and Asthma European Network (GA(2)LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of delegates of 21 national and international societies. This guideline covers the definition and classification of urticaria, taking into account the recent progress in identifying its causes, eliciting factors and pathomechanisms. in addition, it outlines evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS) and is published in Allergy 2014; 69:868-887. Charite, Allergy Ctr Charite, Dept Dermatol & Allergy, Berlin, Germany Med Univ Graz, Dept Dermatol, Graz, Austria Clin San Carlo, Allergy Clin, Paderno Dugnano, Italy Odense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark Univ Southern Denmark, Odense, Denmark Med Univ Silesia, Allergol & Clin Immunol Katowice, Dept Internal Dis, Katowice, Poland Univ Genoa, IRCCS AOU SanMartino, Genoa, Italy Universidade Federal de São Paulo, São Paulo, Brazil Univ Autonoma Barcelona, Hosp Mar Parc Salut Mar, E-08193 Barcelona, Spain Dr DY Patil Med Coll & Hosp, Dept Dermatol, Navi Mumbai, India Fac Med, Dermatol Clin, Coimbra, Portugal Univ Hosp, Coimbra, Portugal Guys & St Thomas Hosp NHS Fdn Trust, St Johns Inst Dermatol, London, England Ctr Appl Res Allergy Quebec, Quebec City, PQ, Canada Hiroshima Univ, Dept Dermatol, Inst Biomed & Hlth Sci, Hiroshima, Japan Med Univ S Carolina, Dept Med, Div Pulm & Crit Care Med, Charleston, SC 29425 USA Hannover Med Sch, Dept Dermatol & Allergy, Hannover, Germany Pantai Hosp Kuala Lumpur, Dept Paediat, Bangsar, Malaysia Univ Hosp Tenon, Dept Dermatol & Allergy, Paris, France Johns Hopkins Asthma & Allergy Ctr, Baltimore, MD USA Ctr Medicodocente Trinidad, Allergy & Clin Immunol Dept, Caracas, Venezuela Univ Hosp, Dept Dermatol, Allergy Unit, Zurich, Switzerland Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB R3T 2N2, Canada Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada Univ Med Ctr Mainz, Dept Dermatol, Mainz, Germany Univ Toronto, Div Allergy & Clin Immunol, Toronto, ON, Canada Technion, Bnai Zion Med Ctr, Fac Med, Haifa, Israel Univ Bari, Dept Biomed Sci & Human Oncol, Unit Dermatol & Venereol, Bari, Italy Universidade Federal de São Paulo, EPM, São Paulo, Brazil Web of Science

Published
2014
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23. Historical epidemiology of hepatitis C virus (HCV) in selected countries

Author

Markus Cornberg, Mette Rye Clausen, Marc Bilodeau, Wahid Doss, E. Gower, Karolin Falconer, Pablo Lázaro, Necati Örmeci, Beat Müllhaupt, Jose Luis Calleja, S. J. Hindman, Wim Laleman, Peer Brehm Christensen, J Parkes, Matthew E. Cramp, Anne Øvrehus, Vratislav Nemecek, Ulus Salih Akarca, Javier García-Samaniego, Sabahattin Kaymakoglu, Christophe Hézode, Jan Sperl, N. Reis, Heiner Wedemeyer, M. C. Mendes Correa, D. Vandijck, Morris Sherman, William Rosenberg, Henrique Sérgio Moraes Coelho, Alexander J. Thompson, Rudolf E. Stauber, Peter Stärkel, Maria Buti, M Guimarães Pessôa, William Sievert, Petr Husa, Wolfgang Vogel, Manal H El-Sayed, Robert P. Myers, Gamal Esmat, İsmail Balik, Fernando L. Gonçales, Francesco Negro, Petr Urbánek, Johannes Wiegand, Martin Kåberg, Christophe Moreno, Kevork M. Peltekian, Ramazan Idilman, S. Mauss, Soo Aleman, José Giria, Chris Estes, Gül Ergör, Ann-Sofi Duberg, Stuart K. Roberts, Nina Weis, Daniel Lavanchy, Kelly Kaita, Michael Gschwantler, Stephen D. Ryder, Hugo Cheinquer, Imam Waked, Ayman Yosry, Antonio Javier Blasco, Jan Gerstoft, Filipe Calinas, Paul Marotta, J. Félix, Henrik Krarup, Maria Lucia Gomes Ferraz, Homie Razavi, Gamal Shiha, Rui Tato Marinho, Christoph Sarrazin, Rui Sarmento-Castro, P. Van Damme, Mel Krajden, Achim Kautz, Harald Hofer, Florian Bihl, Gregory J. Dore, Thomas Berg, Amany Zekry, C. E. Brandão Mello, Alnoor Ramji, I. van Thiel, Paulo R. Ferreira, David Semela, Philip Bruggmann, S. Frankova, H. Van Vlierberghe, Françoise Roudot-Thoraval, Arud Ctr Addict Med, Univ Leipzig, Odense Univ Hosp, Univ Libre Brussels, Universidade Federal do Rio de Janeiro (UFRJ), Hop Henri Mondor, Hosp Santa Maria, Univ Toronto, Nottingham Univ Hosp NHS Trust, Biomed Res Unit, Inst Clin & Expt Med, Ege Univ, Ankara Univ, Osped Cantonale, Univ Montreal, Adv Tech Hlth Serv Res TAISS, Hosp Valle de Hebron, Hosp Santo Antonio Capuchos, Hosp Puerta Hierro, Univ Fed Rio Grande do Sul, Region Hosp Hovedstaden, Hannover Med Sch, German Liver Fdn, Univ Plymouth, Univ New S Wales, Cairo Univ, Orebro Univ Hosp, Univ Orebro, Ain Shams Univ, Dokuz Eylul Univ, Ctr Dis Anal CDA, Karolinska Inst, Exigo Consultores, Universidade Federal de São Paulo (UNIFESP), Hosp Carlos III, Univ Copenhagen, Direccao Geral Saude, Universidade Estadual de Campinas (UNICAMP), Wilhelminenspital Stadt Wien, Universidade de São Paulo (USP), Med Univ Vienna, Masaryk Univ, Univ Manitoba, Hlth Sci Ctr, European Liver Patients Assoc, Istanbul Univ, Univ British Columbia, Aalborg Univ Hosp, Katholieke Univ Leuven, Univ Western Ontario, Univ Dusseldorf, Univ Zurich Hosp, Univ Calgary, Univ Hosp, Natl Inst Publ Hlth, Univ Southhampton, Dalhousie Univ, Capital Dist Hlth Author, Assembleia Republ, Alfred Hosp, Monash Univ, UCL, Ctr Hosp Porto, JW Goethe Univ Hosp, Cantonal Hosp St Gallen, Egyptian Liver Res Inst & Hosp ELRIAH, Monash Hlth, Catholic Univ Louvain, Med Univ Graz, St Vincents Hosp, Univ Melbourne, Charles Univ Prague, Cent Mil Hosp, Deutsch Leberhilfe eV, Ghent Univ Hosp, Univ Ghent, Hasselt Univ, Med Univ Innsbruck, Natl Liver Inst, Copenhagen Univ Hosp, Univ Antwerp, Karolinska Univ Hosp, Bihl, Florian, Negro, Francesco, and Semela, David

Subjects
medicine.medical_specialty, diagnosis, prevalence, Prevalence, ddc:616.07, disease burden, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Acquired immunodeficiency syndrome (AIDS), Virology, Epidemiology, medicine, 030212 general & internal medicine, Disease burden, Hepatitis, ddc:616, Hepatology, treatment, business.industry, Incidence (epidemiology), virus diseases, Hepatitis C, medicine.disease, mortality, 3. Good health, Infectious Diseases, Immunology, HCV, incidence, 030211 gastroenterology & hepatology, epidemiology, Human medicine, hepatitis C, business, Demography
Abstract

Gilead Sciences Chronic infection with hepatitis C virus (HCV) is a leading indicator for liver disease. New treatment options are becoming available, and there is a need to characterize the epidemiology and disease burden of HCV. Data for prevalence, viremia, genotype, diagnosis and treatment were obtained through literature searches and expert consensus for 16 countries. for some countries, data from centralized registries were used to estimate diagnosis and treatment rates. Data for the number of liver transplants and the proportion attributable to HCV were obtained from centralized databases. Viremic prevalence estimates varied widely between countries, ranging from 0.3% in Austria, England and Germany to 8.5% in Egypt. the largest viremic populations were in Egypt, with 6358000 cases in 2008 and Brazil with 2106000 cases in 2007. the age distribution of cases differed between countries. in most countries, prevalence rates were higher among males, reflecting higher rates of injection drug use. Diagnosis, treatment and transplant levels also differed considerably between countries. Reliable estimates characterizing HCV-infected populations are critical for addressing HCV-related morbidity and mortality. There is a need to quantify the burden of chronic HCV infection at the national level. Arud Ctr Addict Med, CH-8005 Zurich, Switzerland Univ Leipzig, D-04109 Leipzig, Germany Odense Univ Hosp, Dept Infect Dis, DK-5000 Odense, Denmark Univ Libre Brussels, Erasme Univ Hosp, Brussels, Belgium Univ Fed Rio de Janeiro, Dept Gastroenterol, Rio de Janeiro, Brazil Hop Henri Mondor, Dept Sante Publ, F-94010 Creteil, France Hosp Santa Maria, Ctr Hosp Lisboa Norte, Dept Gastroenterol, Lisbon, Portugal Univ Toronto, Toronto Gen Hosp, Univ Hlth Network, Toronto, ON M5G 1L7, Canada Nottingham Univ Hosp NHS Trust, Nottingham, England Biomed Res Unit, Nottingham, England Inst Clin & Expt Med, Dept Hepatogastroenterol, Prague, Czech Republic Ege Univ, Izmir, Turkey Ankara Univ, TR-06100 Ankara, Turkey Osped Cantonale, Dept Gastroenterol, Bellinzona, Switzerland Univ Montreal, Dept Med, Liver Unit, Montreal, PQ H3C 3J7, Canada Adv Tech Hlth Serv Res TAISS, Madrid, Spain Hosp Valle de Hebron, CIBERehd, Barcelona, Spain Hosp Santo Antonio Capuchos, Dept Gastroenterol, Ctr Hosp Lisboa Cent, Lisbon, Portugal Hosp Puerta Hierro, Madrid, Spain Univ Fed Rio Grande do Sul, Hosp Clin, Porto Alegre, RS, Brazil Region Hosp Hovedstaden, Region Hovedstaden, Denmark Univ Fed Rio de Janeiro, Dept Clin Med, Rio de Janeiro, Brazil Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany German Liver Fdn, Hannover, Germany Univ Plymouth, Peninsula Schools Med & Dent, Plymouth PL4 8AA, Devon, England Univ New S Wales, Kirby Inst, Sydney, NSW, Australia Cairo Univ, Cairo, Egypt Orebro Univ Hosp, Dept Infect Dis, Orebro, Sweden Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden Ain Shams Univ, Cairo, Egypt Dokuz Eylul Univ, Izmir, Turkey Ctr Dis Anal CDA, Louisville, CO USA Karolinska Inst, Infect Dis Unit, Dept Med Huddinge, Stockholm, Sweden Exigo Consultores, Alhos Vedros, Portugal Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil Hosp Carlos III, CIBERehd, Madrid, Spain Univ Copenhagen, Copenhagen, Denmark Direccao Geral Saude, Lisbon, Portugal Univ Estadual Campinas, Fac Ciencias Med, UNICAMP,Dept Clin Med, Grp Estudo Hepatites,Disciplina Doencas Infeccios, São Paulo, Brazil Wilhelminenspital Stadt Wien, Dept Internal Med 4, Vienna, Austria Univ São Paulo, Sch Med, Div Gastroenterol & Hepatol, São Paulo, Brazil Hop Henri Mondor, Serv Hepatogastroenterol, F-94010 Creteil, France Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Vienna, Austria Masaryk Univ, Univ Hosp Brno, Clin Infect Dis, Brno, Czech Republic Ankara Univ, Dept Gastroenterol, Sch Med, TR-06100 Ankara, Turkey Univ Manitoba, Dept Internal Med, Sect Hepatol, Winnipeg, MB, Canada Hlth Sci Ctr, Viral Hepatitis Invest Unit, Winnipeg, MB, Canada European Liver Patients Assoc, St Truiden, Belgium Istanbul Univ, Istanbul, Turkey Univ British Columbia, British Columbia Ctr Dis Control, Vancouver, BC V5Z 1M9, Canada Aalborg Univ Hosp, Dept Med Gastroenterol, Aalborg, Denmark Aalborg Univ Hosp, Sect Mol Diagnost, Aalborg, Denmark Katholieke Univ Leuven, Univ Hosp Leuven, Louvain, Belgium Univ Western Ontario, Div Gastroenterol, London, ON, Canada Univ Dusseldorf, Dusseldorf, Germany Univ São Paulo, Sch Med, São Paulo, Brazil Univ Zurich Hosp, Swiss HPB Hepatopancreatobiliary Ctr, CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland Univ Calgary, Liver Unit, Div Gastroenterol & Hepatol, Calgary, AB, Canada Univ Hosp, Div Gastroenterol & Hepatol, Geneva, Switzerland Univ Hosp, Div Clin Pathol, Geneva, Switzerland Natl Inst Publ Hlth, Natl Reference Lab Hepatitis, Prague, Czech Republic Univ Southhampton, Southampton, England Dalhousie Univ, Dept Med, Halifax, NS, Canada Dalhousie Univ, Dept Surg, Halifax, NS B3H 4H2, Canada Capital Dist Hlth Author, Serv Hepatol, Queen Elizabeth II Hlth Sci Ctr, Halifax, NS, Canada Univ British Columbia, Dept Gastroenterol, Vancouver, BC V5Z 1M9, Canada Assembleia Republ, Lisbon, Portugal Alfred Hosp, Melbourne, Vic, Australia Monash Univ, Melbourne, Vic 3004, Australia UCL, UCL Inst Liver & Digest Hlth, Div Med, London, England Ctr Hosp Porto, Dept Infect Dis, Oporto, Portugal JW Goethe Univ Hosp, Frankfurt, Germany Cantonal Hosp St Gallen, Div Gastroenterol & Hepatol, St Gallen, Switzerland Egyptian Liver Res Inst & Hosp ELRIAH, Dakahliah, Egypt Monash Hlth, Melbourne, Vic, Australia Catholic Univ Louvain, Clin Univ St Luc, Brussels, Belgium Med Univ Graz, Dept Internal Med, Div Gastroenterol & Hepatol, Graz, Austria St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia Univ Melbourne, Melbourne, Vic, Australia Charles Univ Prague, Dept Internal Med, Fac Med 1, Prague, Czech Republic Cent Mil Hosp, Prague, Czech Republic Deutsch Leberhilfe eV, Cologne, Germany Ghent Univ Hosp, Ghent, Belgium Univ Ghent, B-9000 Ghent, Belgium Hasselt Univ, Dept Hlth Econ & Patient Safety, Diepenbeek, Belgium Med Univ Innsbruck, A-6020 Innsbruck, Austria Natl Liver Inst, Menoufia, Egypt Copenhagen Univ Hosp, Hvidovre, Denmark Univ New S Wales, St George Hosp Clin Sch Med, Sydney, NSW, Australia Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia Univ Antwerp, B-2020 Antwerp, Belgium Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden Karolinska Univ Hosp, Dept Gastroenterol & Hepatol Infect Dis, Stockholm, Sweden Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil Web of Science

Published
2014
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24. Strategies to manage hepatitis C virus (HCV) disease burden

Author

William Sievert, Wolfgang Vogel, C. E. Brandão Mello, Maria Lucia Gomes Ferraz, José Giria, Chris Estes, Homie Razavi, Martin Kåberg, Morris Sherman, Gamal Shiha, Christoph Sarrazin, Johannes Wiegand, J Parkes, Stephen D. Ryder, Filipe Calinas, Jan Sperl, Kevork M. Peltekian, Markus Cornberg, Matthew E. Cramp, Karolin Falconer, Marc Bilodeau, P. Van Damme, Anne Øvrehus, Philip Bruggmann, Maria Buti, Jose Luis Calleja, H. Van Vlierberghe, J. Félix, Achim Kautz, Jan Gerstoft, Peer Brehm Christensen, Gregory J. Dore, Necati Örmeci, Petr Urbánek, Kelly Kaita, N. Reis, Alexander J. Thompson, Javier García-Samaniego, Fernando L. Gonçales, Thomas Berg, S. Frankova, E. Gower, Amany Zekry, Peter Stärkel, Daniel Lavanchy, Florian Bihl, Beat Müllhaupt, Rui Tato Marinho, M. C. Mendes Correa, Pablo Lázaro, Françoise Roudot-Thoraval, Mette Rye Clausen, Vratislav Nemecek, Mel Krajden, Ulus Salih Akarca, İsmail Balik, Wim Laleman, Stuart K. Roberts, S. Mauss, Robert P. Myers, Michael Gschwantler, Wahid Doss, Sabahattin Kaymakoglu, Imam Waked, Hugo Cheinquer, Ayman Yosry, Gül Ergör, Ann-Sofi Duberg, Alnoor Ramji, Henrique Sérgio Moraes Coelho, H. Wedemeyer, Christophe Moreno, Christophe Hézode, Francesco Negro, S. J. Hindman, Henrik Krarup, Dominique Vandijck, I. van Thiel, Gamal Esmat, M Guimarães Pessôa, Manal H El-Sayed, Nina Weis, Paul Marotta, Antonio Javier Blasco, Ramazan Idilman, Rui Sarmento-Castro, Harald Hofer, Paulo R. Ferreira, David Semela, Rudolf E. Stauber, Petr Husa, Soo Aleman, William Rosenberg, Hannover Med Sch, German Liver Fdn, Orebro Univ Hosp, Univ Orebro, Hosp Valle de Hebron, UCL, Inst Clin & Expt Med, Cairo Univ, Ankara Univ, Ghent Univ Hosp, Wilhelminenspital Stadt Wien, Ege Univ, Karolinska Inst, Karolinska Univ Hosp, Univ Leipzig, Osped Cantonale, Univ Montreal, Adv Tech Hlth Serv Res TAISS, Fed Univ State Rio de Janeiro, Arud Ctr Addict Med, Hosp Santo Antonio Capuchos, Hosp Puerta Hierro, Univ Fed Rio Grande do Sul, Odense Univ Hosp, Region Hosp Hovedstaden, Universidade Federal do Rio de Janeiro (UFRJ), Univ Plymouth, Univ New S Wales, Ain Shams Univ, Dokuz Eylul Univ, Ctr Dis Anal CDA, Exigo Consultores, Universidade Federal de São Paulo (UNIFESP), Hosp Carlos III, Univ Copenhagen, Direccao Geral Saude, Universidade Estadual de Campinas (UNICAMP), Universidade de São Paulo (USP), Hop Henri Mondor, Med Univ Vienna, Masaryk Univ, Univ Manitoba, Hlth Sci Ctr, European Liver Patients Assoc, Istanbul Univ, Univ British Columbia, Aalborg Univ Hosp, Katholieke Univ Leuven, Univ Western Ontario, Univ Dusseldorf, Univ Libre Brussels, Univ Zurich Hosp, Univ Calgary, Natl Inst Publ Hlth, Univ Southhampton, Dalhousie Univ & Hepatol Serv, Assembleia Republ, Alfred Hosp, Monash Univ, Nottingham Univ Hosp NHS Trust, Biomed Res Unit, Ctr Hosp Porto, JW Goethe Univ Hosp, Cantonal Hosp St Gallen, Univ Toronto, Egyptian Liver Res Inst & Hosp ELRIAH, Catholic Univ Louvain, Med Univ Graz, St Vincents Hosp, Univ Melbourne, Charles Univ Prague, Cent Mil Hosp, Univ Antwerp, Deutsch Leberhilfe eV, Univ Ghent, Hasselt Univ, Med Univ Innsbruck, Natl Liver Inst, Copenhagen Univ Hosp, Univ Hosp, Monash Hlth, Bihl, Florian, Semela, David, and Negro, Francesco

Subjects
medicine.medical_specialty, diagnosis, Hepatitis C virus, Population, prevalence, ddc:616.07, medicine.disease_cause, law.invention, Telaprevir, disease burden, 03 medical and health sciences, chemistry.chemical_compound, Liver disease, 0302 clinical medicine, Randomized controlled trial, law, Virology, Internal medicine, medicine, 030212 general & internal medicine, education, Disease burden, ddc:616, education.field_of_study, Hepatology, treatment, business.industry, Ribavirin, scenarios, Hepatitis C, medicine.disease, mortality, 3. Good health, Infectious Diseases, chemistry, HCV, incidence, 030211 gastroenterology & hepatology, epidemiology, Human medicine, hepatitis C, business, medicine.drug
Abstract

Gilead Sciences The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. the largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical. Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany German Liver Fdn, Hannover, Germany Orebro Univ Hosp, Dept Infect Dis, Orebro, Sweden Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden Hosp Valle de Hebron, CIBERehd, Barcelona, Spain UCL, Div Med, UCL Inst Liver & Digest Hlth, London, England Inst Clin & Expt Med, Dept Hepatogastroenterol, Prague, Czech Republic Cairo Univ, Cairo, Egypt Ankara Univ, TR-06100 Ankara, Turkey Ghent Univ Hosp, Ghent, Belgium Wilhelminenspital Stadt Wien, Dept Internal Med 4, Vienna, Austria Ege Univ, Izmir, Turkey Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden Karolinska Univ Hosp, Dept Gastroenterol & Hepatol Infect Dis, Stockholm, Sweden Univ Leipzig, D-04109 Leipzig, Germany Osped Cantonale, Dept Gastroenterol, Bellinzona, Switzerland Univ Montreal, Dept Med, Liver Unit, Montreal, PQ H3C 3J7, Canada Adv Tech Hlth Serv Res TAISS, Madrid, Spain Fed Univ State Rio de Janeiro, Dept Gastroenterol, Rio de Janeiro, Brazil Arud Ctr Addict Med, Zurich, Switzerland Hosp Santo Antonio Capuchos, Ctr Hosp Lisboa Cent, Dept Gastroenterol, Lisbon, Portugal Hosp Puerta Hierro, Madrid, Spain Univ Fed Rio Grande do Sul, Hosp Clin, Porto Alegre, RS, Brazil Odense Univ Hosp, Dept Infect Dis, DK-5000 Odense, Denmark Region Hosp Hovedstaden, Region Hovedstaden, Denmark Univ Fed Rio de Janeiro, Dept Clin Med, Rio de Janeiro, Brazil Univ Plymouth, Peninsula Sch Med & Dent, Plymouth PL4 8AA, Devon, England Univ New S Wales, Kirby Inst, Sydney, NSW, Australia Ain Shams Univ, Cairo, Egypt Dokuz Eylul Univ, Izmir, Turkey Ctr Dis Anal CDA, Louisville, CO USA Karolinska Inst, Dept Med Huddinge, Karolinska Univ Hosp, Infect Dis Unit, Stockholm, Sweden Exigo Consultores, Alhos Vedros, Portugal Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil Hosp Carlos III, CIBERehd, Madrid, Spain Univ Copenhagen, Copenhagen, Denmark Direccao Geral Saude, Lisbon, Portugal Univ Estadual Campinas, Fac Ciencias Med, Disciplina Doencas Infecciosas, Grp Estudo Hepatites,Dept Clin Med, São Paulo, Brazil Univ São Paulo, Sch Med, Div Gastroenterol & Hepatol, São Paulo, Brazil Hop Henri Mondor, Serv Hepatogastroenterol, F-94010 Creteil, France Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria Masaryk Univ, Clin Infect Dis, Univ Hosp Brno, Brno, Czech Republic Ankara Univ, Dept Gastroenterol, Sch Med, TR-06100 Ankara, Turkey Univ Manitoba, Dept Internal Med, Sect Hepatol, Winnipeg, MB, Canada Hlth Sci Ctr, Viral Hepatitis Invest Unit, Winnipeg, MB, Canada European Liver Patients Assoc, St Truiden, Belgium Istanbul Univ, Istanbul, Turkey Univ British Columbia, British Columbia Ctr Dis Control, Vancouver, BC V5Z 1M9, Canada Aalborg Univ Hosp, Dept Med Gastroenterol, Aalborg, Denmark Aalborg Univ Hosp, Sect Mol Diagnost, Aalborg, Denmark Katholieke Univ Leuven, Univ Hosp Leuven, Louvain, Belgium Univ Western Ontario, Div Gastroenterol, London, ON, Canada Univ Dusseldorf, Dusseldorf, Germany Univ São Paulo, Sch Med, São Paulo, Brazil Univ Libre Brussels, Erasme Univ Hosp, Brussels, Belgium Univ Zurich Hosp, Swiss HPB Hepatopancreatobiliary Ctr, CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland Univ Calgary, Div Gastroenterol & Hepatol, Liver Unit, Calgary, AB, Canada Natl Inst Publ Hlth, Natl Reference Lab Hepatitis, Prague, Czech Republic Univ Southhampton, Southampton, England Dalhousie Univ & Hepatol Serv, Queen Elizabeth II Hlth Sci Ctr, Capital Dist Hlth Author, Dept Med, Halifax, NS, Canada Dalhousie Univ & Hepatol Serv, Queen Elizabeth II Hlth Sci Ctr, Capital Dist Hlth Author, Dept Surg, Halifax, NS, Canada Univ British Columbia, Dept Gastroenterol, Vancouver, BC V5Z 1M9, Canada Assembleia Republ, Lisbon, Portugal Alfred Hosp, Melbourne, Vic, Australia Monash Univ, Melbourne, Vic 3004, Australia Hop Henri Mondor, Dept Sante Publ, F-94010 Creteil, France Nottingham Univ Hosp NHS Trust, Nottingham, England Biomed Res Unit, Nottingham, England Ctr Hosp Porto, Dept Infect Dis, Oporto, Portugal JW Goethe Univ Hosp, Frankfurt, Germany Cantonal Hosp St Gallen, Div Gastroenterol & Hepatol, St Gallen, Switzerland Univ Toronto, Toronto Gen Hosp, Univ Hlth Network, Toronto, ON M5G 1L7, Canada Egyptian Liver Res Inst & Hosp ELRIAH, Dakahliah, Egypt Catholic Univ Louvain, Clin Univ St Luc, Brussels, Belgium Med Univ Graz, Div Gastroenterol & Hepatol, Dept Internal Med, Graz, Austria St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia Univ Melbourne, Melbourne, Vic, Australia Charles Univ Prague, Dept Internal Med, Fac Med 1, Prague, Czech Republic Cent Mil Hosp, Prague, Czech Republic Univ Antwerp, B-2020 Antwerp, Belgium Deutsch Leberhilfe eV, Cologne, Germany Univ Ghent, Dept Hlth Econ & Patient Safety, B-9000 Ghent, Belgium Hasselt Univ, Diepenbeek, Belgium Med Univ Innsbruck, A-6020 Innsbruck, Austria Natl Liver Inst, Menoufia, Egypt Copenhagen Univ Hosp, Hvidovre, Denmark Univ New S Wales, St George Hosp Clin Sch Med, Sydney, NSW, Australia Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia Univ Hosp, Div Gastroenterol & Hepatol, Geneva, Switzerland Univ Hosp, Div Clin Pathol, Geneva, Switzerland Monash Hlth, Melbourne, Vic, Australia Division of Gastroenterology, Federal University of São Paulo, São Paulo, Brazil Division of Infectious Disease, Federal University of São Paulo, São Paulo, Brazil Web of Science

Published
2014
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25. The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm

Author

Altaf Alam, K. Saeed, N. Nugrahini, Fadi H. Mourad, Andri Sanityoso Sulaiman, Abdul Rahman Bizri, Jon G. Jonasson, Liana Gheorghe, S. Alawadhi, Ala I. Sharara, Sarah Blach, Rino Alvani Gani, Do Young Kim, M. Alzaabi, Young Seok Kim, Matti Maimets, S. Priohutomo, A. Löve, Saeed Hamid, Abdullah M. Assiri, H. Al Quraishi, Adel Alqutub, G. Tayyab, Junko Tanaka, H. Qureshi, A. Salamat, P. Aldins, M. S. Choi, M. T. Barakat, Reza Malekzadeh, M. Sadik, Kwang Hyub Han, Young-Suk Lim, J. Videčnik-Zorman, A. Abdou, Jacques E Mokhbat, Zaigham Abbas, Khalid Alswat, G. Sigmundsdottir, B. Karlsdottir, Marwa Sultan, K. Al Jaberi, Devin Razavi-Shearer, A. Al Rifai, Chris Estes, Abdullah S. Alghamdi, A. Sanityoso Sulaiman, Béla Hunyady, F. Al Braiki, B. Sigurdardottir, Ieva Tolmane, Kathryn Razavi-Shearer, S. El Khoury, Gabor Horvath, Y. Al Serkal, M. Taha, Hamad I. Al-Ashgar, Cesar Yaghi, Abdulrahman Aljumah, Danute Speiciene, Riina Salupere, Irsan Hasan, S. Fakhry, Homie Razavi, Evy Yunihastuti, F. Al Hosani, M. A. Al Mulla, Faisal M. Sanai, Mohamed A. Babatin, N. Andrea, L. Al-Dabal, S. Gregorcic, Arif Nawaz, R. Al-Hakeem, E. S. El Hassan, R. Husni, M. Siddiq, David H. Muljono, Adrian Goldis, A. Almessabi, Jonathan Schmelzer, Mojca Maticic, Laurentius A. Lesmana, A. Baqir, Ibrahim Altraif, Faisal Abaalkhail, Shahin Merat, Mihály Makara, A. Abourached, Jonas Valantinas, Asad Chaudhry, T. Diab, M. Ud Din, Muhammad S. Memon, Jessie Gunter, R. A. Sayegh, Seyed Moayed Alavian, A. M. Siddiqui, H. Fridjonsdottir, Bader Faiyaz Zuberi, M. Umar, Magnus Gottfredsson, Baiba Rozentale, Agita Jeruma, Samsuridjal Djauzi, Almoutaz Hashim, A. Ghafoor Khan, Ottar M. Bergmann, Z. Koutoubi, M. A. Yusuf, H. Tarifi, A. Sibley, Faleh Z. Al-Faleh, Wasim Jafri, P. Rassam, J. I. Farooqi, S. Olafsson, Behzad Hajarizadeh, Valentina Liakina, M. Al Khatry, Ctr Dis Anal, Natl Liver Inst, JW Goethe Univ Hosp, Univ Calgary, Ankara Univ, Hosp Santo Antonio Capuchos, Med Univ Innsbruck, Universidade de São Paulo (USP), Hop Henri Mondor, Adv Tech Hlth Serv Res TAISS, Ege Univ, Karolinska Inst, Karolinska Univ Hosp, Univ Leipzig, Osped Cantonale, Univ Montreal, Fed Univ State Rio de Janeiro, Arud Ctr Addict Med, Hosp Valle de Hebron, Hosp Puerta Hierro, Univ Fed Rio Grande do Sul, Odense Univ Hosp, Reg Hosp Hovedstaden, Universidade Federal do Rio de Janeiro (UFRJ), Univ Plymouth, Univ New S Wales, Cairo Univ, Orebro Univ Hosp, Univ Orebro, Ain Shams Univ, Dokuz Eylul Univ, Exigo Consultores, Universidade Federal de São Paulo (UNIFESP), Inst Clin & Expt Med, Hosp Carlos III, Univ Copenhagen, Direccao Geral Saude, Universidade Estadual de Campinas (UNICAMP), Wilhelminenspital Stadt Wien, Med Univ Vienna, Masaryk Univ, Univ Manitoba, Hlth Sci Ctr, European Liver Patients Assoc, Istanbul Univ, Univ British Columbia, Aalborg Univ Hosp, Katholieke Univ Leuven, Hosp Santa Maria, Univ Western Ontario, Univ Dusseldorf, Univ Libre Brussels, Univ Hosp, Natl Inst Publ Hlth, Univ Southhampton, Dalhousie Univ & Hepatol Serv, Assembleia Republ, Alfred Hosp, Monash Univ, UCL, Nottingham Univ Hosp NHS Trust, Biomed Res Unit, Ctr Hosp Porto, Cantonal Hosp St Gallen, Univ Toronto, Egyptian Liver Res Inst & Hosp, Monash Hlth, Catholic Univ Louvain, Med Univ Graz, St Vincents Hosp, Univ Melbourne, Charles Univ Prague, Cent Mil Hosp, Univ Antwerp, Deutsch Leberhilfe eV, Ghent Univ Hosp, Univ Ghent, Hannover Med Sch, Copenhagen Univ Hosp, Univ Zurich Hosp, Bihl, Florian, Negro, Francesco, and Semela, David

Subjects
Pediatrics, medicine.medical_specialty, diagnosis, Cost effectiveness, Hepatitis C virus, prevalence, ddc:616.07, medicine.disease_cause, disease burden, Liver disease, Virology, Epidemiology, medicine, Disease burden, ddc:616, treatment, Hepatology, business.industry, Incidence (epidemiology), Hepatitis C, medicine.disease, mortality, Infectious Diseases, HCV, Immunology, incidence, epidemiology, Human medicine, hepatitis C, Viral hepatitis, business
Abstract

Gilead Sciences The disease burden of hepatitis C virus (HCV) is expected to increase as the infected population ages. A modelling approach was used to estimate the total number of viremic infections, diagnosed, treated and new infections in 2013. in addition, the model was used to estimate the change in the total number of HCV infections, the disease progression and mortality in 2013-2030. Finally, expert panel consensus was used to capture current treatment practices in each country. Using today's treatment paradigm, the total number of HCV infections is projected to decline or remain flat in all countries studied. However, in the same time period, the number of individuals with late-stage liver disease is projected to increase. This study concluded that the current treatment rate and efficacy are not sufficient to manage the disease burden of HCV. Thus, alternative strategies are required to keep the number of HCV individuals with advanced liver disease and liver-related deaths from increasing. Ctr Dis Anal, Louisville, CO 80027 USA Natl Liver Inst, Menoufia, Egypt JW Goethe Univ Hosp, Frankfurt, Germany Univ Calgary, Liver Unit, Div Gastroenterol & Hepatol, Calgary, AB, Canada Ankara Univ, Dept Gastroenterol, Sch Med, TR-06100 Ankara, Turkey Hosp Santo Antonio Capuchos, Dept Gastroenterol, Ctr Hosp Lisboa Cent, Lisbon, Portugal Med Univ Innsbruck, A-6020 Innsbruck, Austria Univ São Paulo, Sch Med, São Paulo, Brazil Hop Henri Mondor, Serv Hepatogastroenterol, F-94010 Creteil, France Adv Tech Hlth Serv Res TAISS, Madrid, Spain Ege Univ, Izmir, Turkey Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden Karolinska Univ Hosp, Dept Gastroenterol & Hepatol Infect Dis, Stockholm, Sweden Ankara Univ, TR-06100 Ankara, Turkey Univ Leipzig, D-04109 Leipzig, Germany Osped Cantonale, Dept Gastroenterol, Bellinzona, Switzerland Univ Montreal, Dept Med, Liver Unit, Montreal, PQ H3C 3J7, Canada Fed Univ State Rio de Janeiro, Dept Gastroenterol, Rio de Janeiro, Brazil Arud Ctr Addict Med, Zurich, Switzerland Hosp Valle de Hebron, CIBERehd, Barcelona, Spain Hosp Puerta Hierro, Madrid, Spain Univ Fed Rio Grande do Sul, Hosp Clin, Porto Alegre, RS, Brazil Odense Univ Hosp, Dept Infect Dis, DK-5000 Odense, Denmark Reg Hosp Hovedstaden, Copenhagen, Denmark Univ Fed Rio de Janeiro, Dept Clin Med, Rio de Janeiro, Brazil Univ Plymouth, Peninsula Sch Med & Dent, Plymouth PL4 8AA, Devon, England Univ New S Wales, Kirby Inst, Sydney, NSW, Australia Cairo Univ, Cairo, Egypt Orebro Univ Hosp, Dept Infect Dis, Orebro, Sweden Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden Ain Shams Univ, Cairo, Egypt Dokuz Eylul Univ, Izmir, Turkey Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Infect Dis Unit, Stockholm, Sweden Exigo Consultores, Alhos Vedros, Portugal Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil Inst Clin & Expt Med, Dept Hepatogastroenterol, Prague, Czech Republic Hosp Carlos III, CIBERehd, Madrid, Spain Univ Copenhagen, Copenhagen, Denmark Direccao Geral Saude, Lisbon, Portugal Univ Estadual Campinas, Disciplina Doencas Infecciosas, Dept Clin Med, Grp Estudo Hepatites,Fac Ciencias Med,UNICAMP, São Paulo, Brazil Wilhelminenspital Stadt Wien, Dept Internal Med 4, Vienna, Austria Univ São Paulo, Sch Med, Div Gastroenterol & Hepatol, São Paulo, Brazil Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria Masaryk Univ, Univ Hosp Brno, Clin Infect Dis, Brno, Czech Republic Univ Manitoba, Dept Internal Med, Sect Hepatol, Winnipeg, MB, Canada Hlth Sci Ctr, Viral Hepatitis Invest Unit, Winnipeg, MB, Canada European Liver Patients Assoc, St Truiden, Belgium Istanbul Univ, Istanbul, Turkey Univ British Columbia, British Columbia Ctr Dis Control, Vancouver, BC V5Z 1M9, Canada Aalborg Univ Hosp, Dept Med Gastroenterol, Aalborg, Denmark Aalborg Univ Hosp, Sect Mol Diagnost, Aalborg, Denmark Katholieke Univ Leuven, Univ Hosp Leuven, Louvain, Belgium Hosp Santa Maria, Dept Gastroenterol, Ctr Hosp Lisboa Norte, Lisbon, Portugal Univ Western Ontario, Div Gastroenterol, London, ON, Canada Univ Dusseldorf, Dusseldorf, Germany Univ Libre Brussels, Erasme Univ Hosp, Brussels, Belgium Univ Hosp, Div Gastroenterol & Hepatol, Geneva, Switzerland Univ Hosp, Div Clin Pathol, Geneva, Switzerland Natl Inst Publ Hlth, Natl Reference Lab Hepatitis, Prague, Czech Republic Univ Southhampton, Southampton, England Dalhousie Univ & Hepatol Serv, Capital Dist Hlth Author, Queen Elizabeth II Hlth Sci Ctr, Dept Med, Halifax, NS, Canada Dalhousie Univ & Hepatol Serv, Capital Dist Hlth Author, Queen Elizabeth II Hlth Sci Ctr, Dept Surg, Halifax, NS, Canada Univ British Columbia, Dept Gastroenterol, Vancouver, BC V5Z 1M9, Canada Assembleia Republ, Lisbon, Portugal Alfred Hosp, Melbourne, Vic, Australia Monash Univ, Melbourne, Vic 3004, Australia UCL, Div Med, UCL Inst Liver & Digest Hlth, London, England Hop Henri Mondor, Dept Sante Publ, F-94010 Creteil, France Nottingham Univ Hosp NHS Trust, Nottingham, England Biomed Res Unit, Nottingham, England Ctr Hosp Porto, Dept Infect Dis, Oporto, Portugal Cantonal Hosp St Gallen, Div Gastroenterol & Hepatol, St Gallen, Switzerland Univ Toronto, Toronto Gen Hosp, Univ Hlth Network, Toronto, ON M5G 1L7, Canada Egyptian Liver Res Inst & Hosp, Dakahliah, Egypt Monash Hlth, Melbourne, Vic, Australia Catholic Univ Louvain, Clin Univ St Luc, Brussels, Belgium Med Univ Graz, Div Gastroenterol & Hepatol, Dept Internal Med, Graz, Austria St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia Univ Melbourne, Melbourne, Vic, Australia Charles Univ Prague, Dept Internal Med, Fac Med 1, Prague, Czech Republic Cent Mil Hosp, Prague, Czech Republic Univ Antwerp, B-2020 Antwerp, Belgium Deutsch Leberhilfe eV, Cologne, Germany Ghent Univ Hosp, Ghent, Belgium Univ Ghent, Belgium Hasselt Univ, Dept Hlth Econ & Patient Safety, Diepenbeek, Belgium Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany Copenhagen Univ Hosp, Hvidovre, Denmark Univ New S Wales, St George Hosp Clin Sch Med, Sydney, NSW, Australia Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia Univ Zurich Hosp, Swiss HPB Hepatopancreatobiliary Ctr, CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil Web of Science

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2014
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26. Allergic Rhinitis and its Impact on Asthma (ARIA): Achievements in 10 years and future needs

Author

Bousquet, Jean, Schunemann, H. J., Samolinski, B., Demoly, Pascal, Baena-Cagnani, C. E., Bachert, C., Bonini, S., Boulet, L. P., Brozek, J. L., Canonica, G. W., Casale, T. B., Cruz, A. A., Fokkens, W. J., Fonseca, J. A., Wick, R. G. van, Grouse, L., Haahtela, T., Khaltaev, N., Kuna, P., Lockey, R. F., Carlsen, K. C. Lodrup, Mullol, J., Naclerio, R. N., O'Hehir, R. E., Ohta, K., Palkonen, S., Papadopoulos, N. G., Passalacqua, G., Pawankar, R., Price, D., Ryan, D., Simons, F. E. R., Togias, A., Williams, D. M., Yorgancioglu, A., Yusuf, O. M., Aberer, W., Adachi, M., Agache, I., Aït-Khaled, N., Akdis, C. A., Andrianarisoa, A., Annesi-Maesano, I., Ansotegui, I. J., Baiardini, I., Bateman, E. D., Bedbrook, Anna, Beghé, B., Beji, M., Bel, E. H., Kheder, A. Ben, Bennoor, K. S., Bergmann, K. C., Berrissoul, F., Bieber, T., Bindslev-Jensen, C., Blaiss, M. S., Boner, A. L., Bouchard, J., Braido, F., Brightling, C. E., Bush, A., Caballero-Fonseca, F., Calderon, M. A., Calvo, M. A., Camargos, P. A. M., Caraballo, L. R., Carlsen, K. H., Carr, W., A.M, Cepeda Sarabia, Cesario, A., Chavannes, Niels H., Chen, Y. Z., Chiriac, A. M., Pérez, T. Chivato, Chkhartishvili, E., Ciprandi, G., Costa, David J., Cox, L., Custovic, Adnan, Dahl, R., Darsow, U., Blay, F. De, Deleanu, D., Denburg, J. A., Devillier, P., Didi, T., Dokic, D., Dolen, W. K., Douagui, H. B., Dubakiene, R., Durham, S. R., Dykewicz, M. S., El-Gamal, Y., El-Meziane, A., Emuzyte, R., Fiocchi, A., Fletcher, M., Fukuda, T., Gamkrelidze, A., Gereda, J. E., Diaz, S. González, Gotua, M., Guzmán, M. A., Hellings, P. W., Hellquist-Dahl, B., Horak, F., Hourihane, J. O. B., Howarth, P. H., Humbert, M., Ivancevich, J. C., Jackson, Rod T., Just, J., Kalayci, O., Kaliner, M. A., Kalyoncu, A. F., Keil, T., Keith, P. K., Khayat, G., Kim, Y. Y., N'Goran, B. Koffi, Koppelman, G. H., Kowalski, M. L., Kull, I., Kvedariene, V., Larenas-Linnemann, D., Le, Tuyen D., Lemière, C., Li, J., Lieberman, P., Lipworth, B. J., Mahboub, B., Makela, M. J., Martin, F., Marshall, G. D., Martinez, F. D., Masjedi, M. R., Maurer, M., Mavale-Manuel, S., Mazon, A., Melén, E., Meltzer, E. O., Mendez, N. H., Merk, H., Mihaltan, F., Mohammad, Y., Almeida, M. Morais, Muraro, A., Nafti, S., Namazova-Baranova, L., Nekam, K., Neou, A., Niggemann, B., Nizankowska-Mogilnicka, E., Nyembue, T. D., Okamoto, Y., Okubo, K., Orru, M. P., Ouedraogo, S., Ozdemir, C., Panzner, P., Pali-Schöll, I., Park, H. S., Pigearias, B., Pohl, W., Popov, T. A., Postma, D. S., Potter, P., Rabe, K. F., Ratomaharo, J., Reitamo, S., Ring, J., Roberts, R., Rogala, B., Romano, A., Rodriguez, M. Roman, Rosado-Pinto, J., Rosenwasser, L., Rottem, M., Sanchez-Borges, M., Scadding, G. K., Schmid-Grendelmeier, P., Sheikh, A., Sisul, J. C., Sole, D., Sooronbaev, T., Spicak, V., Spranger, O., Stein, R. T., Stoloff, S. W., Sunyer, Jordi, Szczeklik, A., Todo-Bom, A., Toskala, E., Tremblay, Y., Valenta, R., Valero, A. L., Valeyre, D., Valiulis, A., Valovirta, E., Cauwenberge, P. Van, Vandenplas, O., Weel, C. Van, Vichyanond, P., Viegi, Giovanni, Wang, D. Y., Wickman, M., Wöhrl, S., Wright, J., Yawn, B. P., Yiallouros, Panayiotis K., Zar, H. J., Zernotti, M. E., Zhong, N., Zidarn, M., Zuberbier, T., Ang, C. S., Baigenzhin, A. K., Boakye, D. A., Briggs, A. H., Burney, P. G., Busse, W. W., Chuchalin, Alexander G., Haddad, H., Johnston, S. L., Kogevinas, M., Levy, L. M., Mohammadi, A., Oddie, S., Rezagui, D., Terreehorst, I., Warner, J. O., Bousquet, J, Schünemann, Hj, Samolinski, B, Demoly, P, Baena Cagnani, Ce, Bachert, C, Bonini, Sergio, AII - Amsterdam institute for Infection and Immunity, Ear, Nose and Throat, Pulmonology, Yiallouros, Panayiotis K. [0000-0002-8339-9285], Custovic, Adnan [0000-0001-5218-7071], Hop Arnaud Villeneuve, INSERM, McMaster Univ, Med Univ Warsaw, Univ Hosp Montpellier, Catholic Univ, Univ Genoa, Univ Ghent, CNR, Univ Naples 2, Univ Laval, Creighton Univ, Universidade Federal da Bahia (UFBA), CNPq, Univ Amsterdam, Univ Porto, Hosp S Joao & Inst, Hosp CUF Porto, Erasmus MC, Univ Washington, Helsinki Univ Hosp, GARD ARIA Coordinator, Med Univ Lodz, Univ S Florida, James A Haley Vet Hosp, Univ Oslo, CIBERES, Univ Chicago, Alfred Hosp, Monash Univ, Teikyo Univ, EFA European Federat Allergy & Airways Dis Patien, Univ Athens, Nippon Med Sch, Univ Aberdeen, Woodbrook Med Ctr, Univ Edinburgh, Univ Manitoba, NIAID, Univ N Carolina, Celal Bayar Univ, Allergy & Asthma Inst, Med Univ Graz, Showa Univ, Transylvania Univ, Int Union TB & Lung Dis Union, Univ Zurich, Minist Hlth, Univ Paris 06, Hosp Quiron Bizkaia, Univ Cape Town, WHO, Univ Modena & Reggio Emilia, Ctr Hosp Univ Rabta, Hop Mami, Bangladesh Lung Fdn, Natl Inst Dis Chest & Hosp, Charite, Univ Med Ctr, Odense Univ Hosp, Univ Tennessee, Univ Verona, Hop Malbaie, Univ Leicester, Royal Brompton Hosp, Univ London Imperial Coll Sci Technol & Med, Ctr Med Docente La Trinidad Caracas, Univ Austral Chile, Univ Fed Sao Joao del Rei, Univ Cartagena, So Calif Res, Metropolitan Univ Barranquilla, IRCCS San Raffaele Pisana, Univ Cattolica Sacro Cuore, Leiden Univ, Capital Inst Pediat, Ctr Asthma Res & Educ, Univ Hosp, Georgian Natl Univ, Univ Montpellier I, Nova SE Univ, Univ Manchester, Aarhus Univ Hosp, Tech Univ Munich, TUM, Univ Hosp Strasbourg, Univ Med & Pharm Iuliu Hatieganu, Univ Versailles St Quentin, Ctr Hosp Reg Annecy, Univ Ss Cyril & Methodius, Georgia Hlth Sci Univ, Ctr Hosp Univ Beni Messous, Vilnius Univ, Wake Forest Univ, Ain Shams Univ, Egyptian Soc Pediat Allergy & Immunol, Soc Marocaine Malad Resp, Ctr Resp Dis & Allergy, Univ Milan, Educ Hlth, Dokkyo Med Univ, Clin Ricardo Palma, Univ Nuevo Leon UANL, Ctr Allergy & Immunol, Clin Hosp Univ Chile, Univ Hosp Leuven, Cent Reg Denmark, Allergy Ctr Vienna W, Natl Univ Ireland Univ Coll Cork, Univ Southampton, Univ Paris 11, Salvador Univ, Univ St Andrews, Univ Paris, Hacettepe Univ, George Washington Univ, Inst Asthma & Allergy, Hacettepe Univ Hosp, Hotel Dieu France, Univ St Joseph, Natl Med Ctr, Seoul Natl Univ, Korea Asthma Allergy Fdn, Ctr Hosp Univ, Univ Groningen, Karolinska Inst, Vilnius Univ Hosp Santariskiu Klinikos, Hosp Med Sur, Univ Med & Pharm, Hop Sacre Coeur Montreal, Univ Montreal, Guangzhou Med Univ, Univ Dundee, Dubai Hlth Author, Univ Sharjah, Univ Mississippi, Univ Arizona, Shahid Beheshti Univ Med Sci, Universidade Estadual de Maringá (UEM), Eduardo Mondlane Univ, Childrens Hosp La Fe, Karolinska Univ Hosp, Univ Calif San Diego, IMSS, Univ Aachen, Inst Pneumol Marius Nasta, Tishreen Univ, CUF Descobertas Hosp, Univ Padua, Mustapha Hosp, Sci Ctr Childrens Hlth RAMS, Hosp Hospitaller Bros Buda, German Red Cross Hosp Westend, Jagiellonian Univ, Kinshasa Univ, Chiba Univ Hosp, Ctr Hosp Univ Pediat Charles de Gaulle, Marmara Univ, Mem Hlth Grp, Charles Univ Prague, MESSERLI Res Inst, Med Univ Vienna, Univ Vienna, Ajou Univ, NICE, Soc Pneumol Langue Francaise, Krankenhaus Hietzing, Alexanders Univ Hosp, Groote Schuur Hosp, Grosshansdorf Clin, Hop Prive Athis Mons, Univ Wisconsin, Med Univ Silesia, Complesso Integrato Columbus, IRCCS Oasi Maria SS, Son Pisa Primary Care Ctr, Hosp Luz, Univ Missouri, Childrens Mercy Hosp, Emek Med Ctr, Technion Israel Inst Technol, Ctr Med Docente La Trinidad, UCL, Univ Zurich Hosp, Universidade Federal de São Paulo (UNIFESP), Natl Ctr Cardiol & Internal Med, Ctr ACI Immunoflow, GAAPP, Ctr Res Environm Epidemiol CREAL, Pontificia Univ Catolica RGS, Univ Nevada, Hosp Mar, CIBER Epidemiol & Salud Publ CIBERESP, Univ Pompeu Fabra UPF, Coimbra Univ Hosp, Childrens Hosp Philadelphia, Finnish Inst Occupat Hlth, Hosp Clin Barcelona, IDIBAPS, Univ Paris 13, Avicenne Hosp, Lithuanian Natl Council Childs Hlth, Terveystalo Turku, Univ Turku, Catholic Univ Louvain, Radboud Univ Nijmegen, Siriraj Hosp, Clin Physiol IFC, Natl Univ Singapore, Floridsdorf Allergy Ctr FAZ, Bradford Teaching Hosp Fdn Trust, Olmsted Med Ctr, Univ Minnesota, Harvard Univ, Cyprus Univ Technol, Catholic Univ Cordoba, Univ Clin Resp & Allerg Dis, Faculteit Medische Wetenschappen/UMCG, Groningen Research Institute of Pharmacy, Groningen Research Institute for Asthma and COPD (GRIAC), Dermatology, Internal Medicine, Erasmus MC other, Göğüs Hastalıkları, UCL - (MGD) Service de pneumologie, and UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie

Subjects
Allergy, WORLD-HEALTH-ORGANIZATION, GUIDELINES, Medical and Health Sciences, Primary-care, 0302 clinical medicine, QUALITY-OF-LIFE, Health care, Global health, Medicine, Immunology and Allergy, 030223 otorhinolaryngology, Child, Animals, Asthma, Clinical Trials as Topic, Europe, Humans, Practice Guidelines as Topic, Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal, World Health Organization, Persistent types, media_common, Rhinitis, PERSISTENT TYPES, PRIMARY-CARE, Effective primary care and public health [NCEBP 7], 3. Good health, GRADE, medicine.medical_specialty, Immunology, MEDLINE, World-health-organization, CONTROLLED-TRIAL, CLASSIFICATION, 03 medical and health sciences, Quality of life (healthcare), Allergic, EUROPEAN-UNION, rhinitis, Rhinitis, asthma, Allergic Rhinitis and its Impact on Asthma, allergy, GRADE, MANAGEMENT, media_common.cataloged_instance, Controlled-trial, Allergic Rhinitis and its Impact on Asthma, allergy, asthma, European union, Seasonal, business.industry, Guideline, medicine.disease, Perennial, 2008 UPDATE, Family medicine, Quality-of-life, Clinical Medicine, business, 030215 immunology
Abstract

Stallergenes ALK-Abello European Academy of Allergy and Clinical Immunology (EAACI) MSD Novartis Nycomed/Takeda PHADIA/Thermo Fischer 3M AstraZeneca GlaxoSmithKline Merck Frosst Altair Amgen Asmacure Boehringer-Ingelheim Genentech Pharmaxis Schering Wyeth Ache Brazilian Research Council Fundacao de Amparo a Pesquisa da Bahia Fundacao Ciencia e Tecnologia Sociedade Portuguesa de Alergologia e Immunologia Clinica Abdi Ibrahim OrionPharma Nasonebs Merck McNeal Chiesi Nycomed Air Liquid Healthcare Mundipharma Almirall Kyorin Teva UK National Health Service Aerocrine AKL Ltd PREDICTA Swiss National Science Foundation MeDALL Global Allergy and Asthma European Network (GA 2LEN) Christine Kuthe Center for Allergy Research and Education Faes Farma Bial Johnson Johnson Sanofi HAD treasurer Innovative Medicine Initiative (EU) Helse Sor-Ost RHF (Southern and Eastern Norway Regional Health Authority) MEDA Alcon ISTA Thermo-Fisher Airsonett Medical Research Council Moulton Charitable Trust AB Science Canadian Institutes for Health Research AllerGen NCE Merck/Schering-Plough Circassia University Hospital Medical School of Universidad Autonoma de Nuevo Leon, Mexico Children's Research Foundation (Ireland) Danone Food Standards Agency (United Kingdom) European Union (EU) DTG Netherlands Asthma Foundation Merck-Sharp-Dohme, Mexico Allerquim Mexico Abbott Apotex HRA MedImmune Schering-Plough Proctor Gamble Sunovion (Sepracor) Phadia Servier CSC JohnsonJohnson Oxygen Plus New Medics European Respiratory Society Societe de Pneumologie de Langue Francaise Asthma Ministry of Health, Welfare, and Labor Altana Takeda UCB Uriach advisory board NAPP Royal College of GPs Clinical Champion in Allergy Agency for Healthcare Research and Quality (AHRQ) AnseII Bayer Schering OST Fujisawa IHAL Henkel Allergic rhinitis (AR) and asthma represent global health problems for all age groups. Asthma and rhinitis frequently coexist in the same subjects. Allergic Rhinitis and its Impact on Asthma (ARIA) was initiated during a World Health Organization workshop in 1999 (published in 2001). ARIA has reclassified ARas mild/moderate-severe and intermittent/persistent. This classification closely reflects patients' needs and underlines the close relationship between rhinitis and asthma. Patients, clinicians, and other health care professionals are confronted with various treatment choices for the management of AR. This contributes to considerable variation in clinical practice, and worldwide, patients, clinicians, and other health care professionals are faced with uncertainty about the relative merits and downsides of the various treatment options. in its 2010 Revision, ARIA developed clinical practice guidelines for the management of AR and asthma comorbidities based on the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system. ARIA is disseminated and implemented in more than 50 countries of the world. Ten years after the publication of the ARIAWorld Health Organization workshop report, it is important to make a summary of its achievements and identify the still unmet clinical, research, and implementation needs to strengthen the 2011 European Union Priority on allergy and asthma in children. (J Allergy Clin Immunol 2012;130:1049-62.) Kryolan Leti MSO Procter and Gamble Sanofi-Aventis Scientific Advisory Board for the German Society for Allergy and Clinical Immunology German Federal Ministry of Consumer Protection European Centre for Allergy Research Foundation (ECARF) Hop Arnaud Villeneuve, Dept Resp Dis, Univ Hosp, Montpellier, France INSERM, U1018, CESP Ctr Res Epidemiol & Populat Hlth, Resp & Environm Epidemiol Team, Villejuif, France McMaster Univ, Dept Clin Epidemiol & Biostat & Med, Hamilton, ON, Canada Med Univ Warsaw, Dept Prevent Environm Hazards & Allergol, Warsaw, Poland Univ Hosp Montpellier, Hop Arnaud Villeneuve, INSERM, U657, Montpellier, France Catholic Univ, Fac Med, Res Ctr Resp Med CIMER, Cordoba, Argentina Univ Genoa, Sch Specializat, Genoa, Italy Univ Ghent, Dept Otorhinolaryngol, Upper Airways Res Lab, B-9000 Ghent, Belgium CNR, Inst Translat Pharmacol, Rome, Italy Univ Naples 2, Naples, Italy Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada Univ Genoa, Dept Internal Med, DIMI, I-16126 Genoa, Italy Creighton Univ, Dept Med, Div Allergy & Immunol, Omaha, NE 68178 USA Univ Fed Bahia, ProAR Nucleo Excelencia Asma, Salvador, BA, Brazil CNPq, Salvador, BA, Brazil Univ Amsterdam, Dept Otorhinolaryngol, NL-1012 WX Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, NL-1105 AZ Amsterdam, Netherlands Univ Porto, Sch Med, Dept Hlth Informat & Decis Sci, P-4100 Oporto, Portugal Univ Porto, Sch Med, CINTESIS, P-4100 Oporto, Portugal Hosp S Joao & Inst, Dept Allergy, Oporto, Portugal Hosp CUF Porto, Oporto, Portugal Erasmus MC, Dept Internal Med, Sect Allergol, Rotterdam, Netherlands Univ Washington, Sch Med, Seattle, WA USA Helsinki Univ Hosp, Dept Allergy, Skin & Allergy Hosp, Helsinki, Finland GARD ARIA Coordinator, Geneva, Switzerland Med Univ Lodz, Dept Internal Med Asthma & Allergy, Barlicki Univ Hosp, Lodz, Poland Univ S Florida, Coll Med, Dept Internal Med, Div Allergy & Immunol, Tampa, FL 33612 USA James A Haley Vet Hosp, Tampa, FL USA Univ Oslo, Oslo Univ Hosp, Dept Paediat, Oslo, Norway CIBERES, IDIBAPS, Hosp Clin, Rhinol Unit,ENT Dept, Barcelona, Spain CIBERES, IDIBAPS, Hosp Clin, Smell Clin,ENT Dept, Barcelona, Spain Univ Chicago, Dept Otolaryngol Head & Neck Surg, Chicago, IL 60637 USA Alfred Hosp, Dept Allergy Immunol & Resp Med, Melbourne, Vic, Australia Monash Univ, Melbourne, Vic 3004, Australia Teikyo Univ, Sch Med, Dept Med, Div Resp Med & Allergol, Tokyo 173, Japan EFA European Federat Allergy & Airways Dis Patien, Brussels, Belgium Univ Athens, Dept Allergy, Pediat Clin 2, Athens, Greece Nippon Med Sch, Bunkyo Ku, Tokyo 113, Japan Univ Aberdeen, Dept Primary Care Resp Med, Aberdeen, Scotland Woodbrook Med Ctr, Loughborough, Leics, England Univ Edinburgh, Edinburgh, Midlothian, Scotland Univ Manitoba, Fac Med, Winnipeg, MB, Canada NIAID, Bethesda, MD 20892 USA Univ N Carolina, Sch Pharm, Chapel Hill, NC USA Celal Bayar Univ, Sch Med, Dept Pulmonol, Manisa, Turkey Allergy & Asthma Inst, Islamabad, Pakistan Med Univ Graz, Dept Dermatol, Graz, Austria Showa Univ, Sch Med, Div Allergol & Resp Med, Tokyo 142, Japan Transylvania Univ, Fac Med, Brasov, Romania Int Union TB & Lung Dis Union, Paris, France Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland Minist Hlth, Publ Hosp Med Serv, Antananarivo, Madagascar INSERM, EPAR U707, Paris, France Univ Paris 06, EPAR, UMR S, Paris, France Hosp Quiron Bizkaia, Dept Allergy & Immunol, Erandio Bilbao, Spain Univ Cape Town, Dept Med, Fac Hlth Sci, Div Pulmonol, ZA-7925 Cape Town, South Africa WHO, Collaborating Ctr Asthma & Rhinitis, Montpellier, France Univ Modena & Reggio Emilia, Dept Oncol Hematol & Resp Dis, Modena, Italy Ctr Hosp Univ Rabta, Serv Pneumol Allergol, Tunis, Tunisia Univ Amsterdam, Acad Med Ctr, Dept Pulmonol, NL-1105 AZ Amsterdam, Netherlands Hop Mami, Ariana, Tunisia Bangladesh Lung Fdn, Dhaka, Bangladesh Natl Inst Dis Chest & Hosp, Dhaka, Bangladesh Charite, Dept Dermatol, Allergy Ctr Charite, D-13353 Berlin, Germany Univ Med Ctr, Dept Dermatol & Allergy, Bonn, Germany Odense Univ Hosp, Dept Dermatol, DK-5000 Odense, Denmark Odense Univ Hosp, Allergy Ctr, DK-5000 Odense, Denmark Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA Univ Verona, Dept Paediat, I-37100 Verona, Italy Univ Laval, Fac Med, Quebec City, PQ G1K 7P4, Canada Hop Malbaie, La Malbaie, PQ, Canada Univ Leicester, Inst Lung Hlth, Leicester LE1 7RH, Leics, England Royal Brompton Hosp, Dept Paediat Resp Med, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Sect Allergy & Clin Immunol, London, England Ctr Med Docente La Trinidad Caracas, Dept Immunol, Caracas, Venezuela Univ Austral Chile, Fac Med, Dept Pediat, Valdivia, Chile Univ Fed Sao Joao del Rei, Hlth Sci Ctr, Hlth Sci Postgrad Program, Divinopolis, Brazil Univ Cartagena, Immunol Res Inst, Cartagena de Indias, Colombia So Calif Res, Mission Viejo, CA USA Metropolitan Univ Barranquilla, Allergy & Immunol Lab, Barranquilla, Colombia IRCCS San Raffaele Pisana, Rome, Italy Univ Cattolica Sacro Cuore, Dept Thorac Surg, Rome, Italy Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands Capital Inst Pediat, Asthma Clin, Natl Cooperat Grp Pediat Res Asthma, Beijing, Peoples R China Capital Inst Pediat, Educ Ctr, Beijing, Peoples R China Ctr Asthma Res & Educ, Beijing, Peoples R China Hop Arnaud Villeneuve, Univ Hosp, Allergy Unit, Montpellier, France Univ Hosp, Dept Allergol, Sch Med CEU San Pablo Madrid, Madrid, Spain Georgian Natl Univ, AIETI Med Sch, SEU Clin, Med Ctr, Tbilisi, Rep of Georgia Univ Genoa, Dept Internal Med, IRCCS Azienda Osped Univ San Martino, I-16126 Genoa, Italy Univ Montpellier I, Primary Care Dept, Montpellier, France Nova SE Univ, Coll Osteopath Med, Davie, FL USA Univ Manchester, Manchester, Lancs, England Aarhus Univ Hosp, Dept Resp Dis, DK-8000 Aarhus, Denmark Tech Univ Munich, Dept Dermatol & Allergy Biederstein, Munich, Germany TUM, Div Environm Dermatol, Munich, Germany TUM, Allergy Helmholtz Ctr, Munich, Germany Univ Hosp Strasbourg, Chest Dis Dept, Div Pulmonol Asthma & Allergol, Strasbourg, France Univ Med & Pharm Iuliu Hatieganu, Dept Allergy, Med Clin 3, Romanian Soc Allergy & Clin Immunol, Cluj Napoca, Romania McMaster Univ, AllerGen NCE, Dept Med, Hamilton, ON, Canada McMaster Univ, AllerGen NCE, Michael G DeGroote Sch Med, Div Clin Immunol & Allergy,Fac Hlth Sci, Hamilton, ON, Canada Univ Versailles St Quentin, Hop Foch, UPRES EA 220, Suresnes, France Ctr Hosp Reg Annecy, Serv Pneumol, Annecy, France Univ Ss Cyril & Methodius, Univ Clin Pulmonol & Allergy, Skopje, Macedonia Georgia Hlth Sci Univ, Augusta, GA USA Ctr Hosp Univ Beni Messous, Serv Pneumoallergol, Algiers, Algeria Vilnius Univ, Fac Med, Collaborating Ctr GA2LEN, Vilnius, Lithuania Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA Ain Shams Univ, Childrens Hosp, Pediat Allergy & Immunol Unit, Cairo, Egypt Egyptian Soc Pediat Allergy & Immunol, Cairo, Egypt Soc Marocaine Malad Resp, Casablanca, Morocco Ctr Resp Dis & Allergy, Casablanca, Morocco Vilnius Univ, Fac Med, Vilnius, Lithuania Univ Milan, Sch Med, Melloni Hosp, Milan, Italy Educ Hlth, Warwick, England Dokkyo Med Univ, Mibu, Tochigi, Japan WHO, Country Off Georgia, Tbilisi, Rep of Georgia Clin Ricardo Palma, Lima, Peru Univ Nuevo Leon UANL, Hosp Univ, Fac Med, Monterrey, Mexico Ctr Allergy & Immunol, Tbilisi, Rep of Georgia Clin Hosp Univ Chile, Dept Med, Immunol & Allergol Div, Santiago, Chile Univ Hosp Leuven, Dept Otorhinolaryngol Head & Neck Surg, Louvain, Belgium Cent Reg Denmark, Ctr Publ Hlth & Qual Improvement, Aarhus, Denmark Allergy Ctr Vienna W, Vienna, Austria Natl Univ Ireland Univ Coll Cork, Dept Paediat & Child Hlth, Cork, Ireland Univ Southampton, Fac Med, Southampton SO9 5NH, Hants, England Univ Paris 11, Serv Pneumol, Hop Antoine Beclere, AP HP,INSERM,U999, Clamart, France Salvador Univ, Sch Med, Dept Immunol, Buenos Aires, DF, Argentina Univ St Andrews, St Andrews, Fife, Scotland Univ Paris, APHP, Ctr Asthme & Allergies, Grp Hosp Trousseau La Roche Guyon, F-75252 Paris, France Hacettepe Univ, Sch Med, Pediat Allergy & Asthma Unit, Ankara, Turkey George Washington Univ, Sch Med, Washington, DC USA Inst Asthma & Allergy, Chevy Chase, MD USA Hacettepe Univ Hosp, Dept Chest Dis, Adult Allergy Unit, Ankara, Turkey Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany McMaster Univ, Hamilton, ON, Canada Hotel Dieu France, Serv Pneumol & Reanimat Med, Beirut, Lebanon Univ St Joseph, Fac Med, Beirut, Lebanon Natl Med Ctr, Seoul, South Korea Seoul Natl Univ, Seoul, South Korea Korea Asthma Allergy Fdn, Seoul, South Korea Ctr Hosp Univ, Serv Malad Resp, Abidjan, Cote Ivoire Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Beatrix Childrens Hosp,Dept Pediat Pulmonol & Ped, Groningen, Netherlands Med Univ Lodz, Dept Immunol Rheumatol & Allergy, Lodz, Poland Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden Karolinska Inst, Sachs Childrens Hosp, Stockholm, Sweden Vilnius Univ, Ctr Pulmonol & Allergol, Vilnius, Lithuania Vilnius Univ Hosp Santariskiu Klinikos, Vilnius, Lithuania Hosp Med Sur, Dept Allergy, Mexico City, DF, Mexico Univ Med & Pharm, Thanh Pho Ho Chi Minh, Vietnam Hop Sacre Coeur Montreal, Montreal, PQ, Canada Univ Montreal, Montreal, PQ, Canada Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China Univ Tennessee, Coll Med, Memphis, TN USA Univ Dundee, Ninewells Hosp, Asthma & Allergy Res Grp, Dundee, Scotland Dubai Hlth Author, Sharjah, U Arab Emirates Univ Sharjah, Sharjah, U Arab Emirates Univ Mississippi, Med Ctr, Div Clin Immunol & Allergy, Jackson, MS 39216 USA Univ Arizona, Coll Med, Arizona Resp Ctr, Tucson, AZ USA Univ Arizona, Inst BIO5, Tucson, AZ USA Shahid Beheshti Univ Med Sci, NRITLD, Tehran, Iran Shahid Beheshti Univ Med Sci, Chron Resp Dis Res Ctr, Tehran, Iran Charite, Dept Dermatol & Allergy, D-13353 Berlin, Germany Maputo Cent Hosp, Dept Peadiat, Maputo, Mozambique Eduardo Mondlane Univ, Fac Med, Maputo, Mozambique Childrens Hosp La Fe, Unit Pediat Allergy & Pneumol, Valencia, Spain Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden Univ Calif San Diego, Allergy & Asthma Med Grp, San Diego, CA 92103 USA Univ Calif San Diego, Res Ctr, San Diego, CA 92103 USA IMSS, Dept Allergy & Clin Immunol, Ctr Med Nacl Siglo 21, Mexico City, DF, Mexico Univ Aachen, Dept Dermatol, Aachen, Germany Inst Pneumol Marius Nasta, Bucharest, Romania Tishreen Univ, Sch Med, Dept Internal Med, WHO EMRO Collaborating Ctr Training & Res Chron R, Latakia, Syria CUF Descobertas Hosp, Immunoallergy Dept, Lisbon, Portugal Univ Padua, Dept Pediat, Food Allergy Referral Ctr Veneto Reg, Padua, Italy Mustapha Hosp, Algiers, Algeria Sci Ctr Childrens Hlth RAMS, Moscow, Russia Hosp Hospitaller Bros Buda, Budapest, Hungary Charite, Allergie Ctr Charite ECARF, Dept Dermatol Venerol & Allergy, D-13353 Berlin, Germany German Red Cross Hosp Westend, Berlin, Germany Jagiellonian Univ, Sch Med, Dept Pulmonol, Krakow, Poland Kinshasa Univ, ENT Dept, Kinshasa, Zaire Chiba Univ Hosp, Dept Otorhinolaryngol, Chiba, Japan Nippon Med Sch, Dept Otolaryngol, Bunkyo Ku, Tokyo 113, Japan Ctr Hosp Univ Pediat Charles de Gaulle, Ouagadougou, Burkina Faso Marmara Univ, Div Pediat Allergy & Immunol, Istanbul, Turkey Mem Hlth Grp, Istanbul, Turkey Charles Univ Prague, Fac Med Plzen, Dept Immunol & Allergol, Prague, Czech Republic MESSERLI Res Inst, Vienna, Austria Med Univ Vienna, Univ Vet Med Vienna, Vienna, Austria Univ Vienna, Vienna, Austria Ajou Univ, Sch Med, Suwon 441749, South Korea NICE, Paris, France Soc Pneumol Langue Francaise, Paris, France Krankenhaus Hietzing, Karl Landsteiner Inst Expt & Clin Pneumol, Dept Pulm Med, Vienna, Austria Alexanders Univ Hosp, Clin Allergy & Asthma, Sofia, Bulgaria Univ Groningen, Univ Med Ctr Groningen, GRIAC Res Inst, Dept Pulmonol, Groningen, Netherlands Univ Cape Town, Lung Inst, ZA-7925 Cape Town, South Africa Groote Schuur Hosp, ZA-7925 Cape Town, South Africa Leiden Univ, Dept Pulmonol, Med Ctr, Leiden, Netherlands Grosshansdorf Clin, Grosshansdorf, Germany Hop Prive Athis Mons, Serv Pneumol, Athis Mons, France Helsinki Univ Hosp, Dept Dermatol, Skin & Allergy Hosp, Helsinki, Finland Tech Univ Munich, CKCARE, Dept Dermatol Allergy Biederstein, Munich, Germany Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA Med Univ Silesia, Dept & Clin Internal Dis Allergol & Clin Immunol, Katowice, Poland Complesso Integrato Columbus, Allergy Unit, Rome, Italy IRCCS Oasi Maria SS, Troina, Italy Son Pisa Primary Care Ctr, IB Salut Balear Hlth Serv, Int Primary Care Resp Grp, Palma de Mallorca, Spain Hosp Luz, Immunoallergy Dept, Lisbon, Portugal Univ Missouri, Kansas City Sch Med, Kansas City, MO 64110 USA Childrens Mercy Hosp, Kansas City, MO USA Emek Med Ctr, Afula, Israel Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel Ctr Med Docente La Trinidad, Dept Allergy & Clin Immunol, Caracas, Venezuela UCL, Royal Natl TNE Hosp, London, England Univ Zurich Hosp, Dept Dermatol, Allergy Unit, CH-8091 Zurich, Switzerland Univ Edinburgh, Sch Med, Ctr Populat Hlth Sci, Allergy & Resp Res Grp, Edinburgh, Midlothian, Scotland Universidade Federal de São Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil Natl Ctr Cardiol & Internal Med, Bishkek, Kyrgyzstan Ctr ACI Immunoflow, Czech Initiat Asthma, Prague, Czech Republic GAAPP, Vienna, Austria Ctr Res Environm Epidemiol CREAL, Barcelona, Spain Pontificia Univ Catolica RGS, Sch Med, Porto Alegre, RS, Brazil Univ Nevada, Sch Med, Reno, NV 89557 USA Hosp Mar, Municipal Inst Med Res IMIM, Barcelona, Spain CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain Univ Pompeu Fabra UPF, Barcelona, Spain Jagiellonian Univ, Coll Med, Krakow, Poland Coimbra Univ Hosp, Immunoallergy Dept, Coimbra, Portugal Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA Finnish Inst Occupat Hlth, Helsinki, Finland Univ Laval, Fac Med, Dept Obstet & Gynecol, Laval, PQ, Canada Med Univ Vienna, Christian Doppler Lab Allergy Res, Div Immunopathol, Dept Pathophysiol & Allergy Res,Ctr Pathophysiol, Vienna, Austria Hosp Clin Barcelona, Dept Pneumol, Allergy Unit, Immunoallergia Resp Clin, Barcelona, Spain IDIBAPS, Barcelona, Spain CIBERES, Barcelona, Spain Univ Paris 13, Bobigny, France Avicenne Hosp, AP HP, Bobigny, France Vilnius Univ, Fac Med, Dept Paediat, Vilnius, Lithuania Lithuanian Natl Council Childs Hlth, Vilnius, Lithuania Terveystalo Turku, Allergy Clin, Turku, Finland Univ Turku, Dept Lung Dis & Clin Immunol, Turku, Finland Univ Ghent, Dept Otorhinolaryngol, B-9000 Ghent, Belgium Catholic Univ Louvain, Univ Hosp Mt Godinne, Yvoir, Belgium Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Care, NL-6525 ED Nijmegen, Netherlands Siriraj Hosp, Fac Med, Dept Pediat, Bangkok, Thailand CNR, IBIM, Palermo, Italy Clin Physiol IFC, Pisa, Italy Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore Floridsdorf Allergy Ctr FAZ, Vienna, Austria Med Univ Vienna, Dept Dermatol, DIAID, Vienna, Austria Bradford Teaching Hosp Fdn Trust, Bradford Inst Hlth Res, Bradford, W Yorkshire, England Olmsted Med Ctr, Dept Res, Rochester, MN USA Univ Minnesota, Dept Family & Community Hlth, Rochester, MN USA Harvard Univ, Sch Publ Hlth, Cyprus Int Inst Environm & Publ Hlth Assoc, Limassol, Cyprus Cyprus Univ Technol, Limassol, Cyprus Univ Cape Town, Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, ZA-7925 Cape Town, South Africa Catholic Univ Cordoba, Sch Med, Dept Otorhinolaryngol, Cordoba, Argentina Guangzhou Med Univ, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China Guangzhou Med Univ, State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China Univ Clin Resp & Allerg Dis, Golnik, Slovenia Charite, Network Excellence, Global Allergy & Asthma European Network GA2LEN, D-13353 Berlin, Germany Universidade Federal de São Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil Web of Science

Published
2012
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27. Discrimination of bile acids by the rainbow trout olfactory system: Evidence as potential pheromone

Author

Toshiaki J. Hara, Percilia Cardoso Giaquinto, Universidade Estadual Paulista (Unesp), Fisheries & Oceans Canada, Univ Manitoba, Universidade Estadual Paulista (UNESP), Canada Department of Fisheries and Oceans, and University of Manitoba

Subjects
Olfactory system, endocrine system, animal structures, animal diseases, Olfaction, Biology, digestive system, chemical signals, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, medicine, lcsh:QH301-705.5, bile acids, Olfactory receptor, urogenital system, General Medicine, rainbow trout, medicine.anatomical_structure, chemistry, Biochemistry, lcsh:Biology (General), Sex pheromone, Pheromone, Rainbow trout, Taurolithocholic acid, General Agricultural and Biological Sciences, pheromones, Olfactory epithelium, electro-olfactogram, olfaction
Abstract

Electro-olfactogram recording was used to determine whether the olfactory epithelium of adult rainbow troutis specifically sensitive to bile acids, some of which have been hypothesized to function as pheromones. Of 38bile acids that had been pre-screened for olfactory activity, 6 were selected. The rainbow trout-specific bileacids, taurocholic acid (TCA), and taurolithocholic acid 3-sulfate (TLS) were the most potent compoundstested. TLS had a distinctive dose-response curve. Cross-adaptation experiments demonstrated that sensitivityto bile acids is attributable to at least 3 independent classes of olfactory receptor sites. Our data suggest thatbile acids are discriminated by olfaction in rainbow trout, supporting the possibility that these compoundsfunction as pheromones. Key terms: bile acids, chemical signals, electro-olfactogram, olfaction, pheromones, rainbow trout. INTRODUCTION Bile acids and amino acids, together withsex steroids and prostaglandins, comprisefour major classes of chemicals that havebeen identified as specific olfactorystimulants for fishes and their stimulatoryeffectiveness characterized in over 30species (Hara, 1994a; Hara, 1994b).Extreme olfactory sensitivities to bileacids, coupled with their wide distributionand chemical variations have beenimplicated for their role in fish behavior(Dolving et al.,1980; Hara et al., 1984; Solaand Tosi, 1993; Zhang et al., 2001).Although the gustatory function of bileacids has yet to be ascertained, behavioralevidence suggests that one of theirfunctions as olfactory stimulants may be toserve as pheromones for migratoryanadromous fishes, some of which appearto recognize and select the odor ofconspecifics when choosing spawningstreams (Doving et al., 1980; Stabell,1992). Studies using electroencephalogramrecording showed that bile acids are potentolfactory stimulants for the grayling andArctic charr (Doving et al., 1980).Taurocholic acid (TCA) is a potentolfactory stimulus to several salmonids(Hara et al, 1984; Quinn and Hara, 1986;Zhang and Hara, 1991; Hara and Zhang,1996) and goldfish (Sorensen et al., 1987).In teleosts, the principal biliary bileacids are (1) sulphated bile alcohol, mainly5-cyprinol and 5-chimaerol; and (2) C

Published
2008

28. Multivariate analysis for data mining to characterize poultry house environment in winter.

Author

Li M, Zhou Z, Zhang Q, Zhang J, Suo Y, Liu J, Shen D, Luo L, Li Y, and Li C

Subjects
Animals, Multivariate Analysis, Air Pollution, Indoor analysis, Animal Husbandry methods, Cluster Analysis, Environmental Monitoring methods, Housing, Animal, Chickens physiology, Seasons, Data Mining
Abstract

The processing and analysis of massive high-dimensional datasets are important issues in precision livestock farming (PLF). This study explored the use of multivariate analysis tools to analyze environmental data from multiple sensors located throughout a broiler house. An experiment was conducted to collect a comprehensive set of environmental data including particulate matter (TSP, PM 10 , and PM 2.5 ), ammonia, carbon dioxide, air temperature, relative humidity, and in-cage and aisle wind speeds from 60 locations in a typical commercial broiler house. The dataset was divided into 3 growth phases (wk 1-3, 4-6, and 7-9). Spearman's correlation analysis and principal component analysis (PCA) were used to investigate the latent associations between environmental variables resulting in the identification of variables that played important roles in indoor air quality. Three cluster analysis methods; k-means, k-medoids, and fuzzy c-means cluster analysis (FCM), were used to group the measured parameters based on their environmental impact in the broiler house. In general, the Spearman and PCA results showed that the in-cage wind speed, aisle wind speed, and relative humidity played critical roles in indoor air quality distribution during broiler rearing. All 3 clustering methods were found to be suitable for grouping data, with FCM outperforming the other 2. Using data clustering, the broiler house spaces were divided into 3, 2, and 2 subspaces (clusters) for wk 1 to 3, 4 to 6, and 7 to 9, respectively. The subspace in the center of the house had a poorer air quality than other subspaces., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

Published
2024
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29. Facial Nerve Schwannoma Treatment with Stereotactic Radiosurgery (SRS) versus Resection followed by SRS: Outcomes and a Management Protocol.

Author

Dayawansa S, Dumot C, Mantziaris G, Mehta GU, Lekovic GP, Kondziolka D, Mathieu D, Reda WA, Liscak R, Cheng-Chia L, Kaufmann AM, Barnet G, Trifiletti DM, Lunsford LD, and Sheehan J

Abstract

Background  Stereotactic radiosurgery (SRS) and resection are treatment options for patients with facial nerve schwannomas without mass effect. Objective  This article evaluates outcomes of patients treated with SRS versus resection + SRS. Method  We retrospectively compared 43 patients treated with SRS to 12 patients treated with resection + SRS. The primary study outcome was unfavorable combined endpoint, defined as worsening or new clinical symptoms, and/or tumor radiological progression. SRS (38.81 ± 5.3) and resection + SRS (67.14 ± 11.8) groups had similar clinical follow-ups. Results  At the time of SRS, the tumor volumes of SRS (mean ± standard error; 1.83 ± 0.35 mL) and resection + SRS (2.51 ± 0.75 mL) groups were similar. SRS (12.15 ± 0.08 Gy) and resection + SRS (12.16 ± 0.14 Gy) groups received similar radiation doses. SRS group (42/43, 98%) had better local tumor control than the resection + SRS group (10/12, 83%, p  = 0.04). Most of SRS (32/43, 74%) and resection + SRS (10/12, 83%) group patients reached a favorable combined endpoint following SRS ( p  = 0.52). Considering surgical associated side effects, only 2/10 patients of the resection + SRS group reached a favorable endpoint ( p  < 0.001). Patients of SRS group, who are > 34 years old ( p  = 0.02), have larger tumors (> 4 mL, 0.04), internal auditory canal (IAC) segment tumor involvement ( p  = 0.01) were more likely to reach an unfavorable endpoint. Resection + SRS group patients did not show such a difference. Conclusion  While resection is still needed for larger tumors, SRS offers better clinical and radiological outcomes compared to resection followed by SRS for facial schwannomas. Younger age, smaller tumors, and non-IAC situated tumors are factors that portend a favorable outcome., Competing Interests: Conflict of Interest None declared., (Thieme. All rights reserved.)

Published
2022
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30. 3D breast microwave imaging based on wavefront reconstruction.

Author

Flores-Tapia D, Thomas G, Ashtari A, and Pistorius S

Subjects
Diagnostic Imaging instrumentation, Female, Humans, Image Enhancement methods, Phantoms, Imaging, Reproducibility of Results, Sensitivity and Specificity, Algorithms, Breast pathology, Breast Neoplasms diagnosis, Diagnostic Imaging methods, Image Interpretation, Computer-Assisted methods, Imaging, Three-Dimensional methods, Microwaves
Abstract

Currently, breast cancer is the leading cause of cancer death in women between the ages of 15 and 54, and the second cause of cancer death in women 55 to 74. In recent years, Breast Microwave Imagery (BMI) has shown its potential as a promising breast cancer detection technique. This imaging technology is based on the electrical characteristic differences that exist between normal and malignant breast tissues at the microwave frequency range. A novel reconstruction approach for the formation of 3D BMI models is proposed in this paper. This technique uses the phase differences introduced during the collection of target responses in order to determine the correct spatial location of the different scatterers that constitute the final image. The proposed method yielded promising results when applied to simulated data.

Published
2006
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31. Differential regulation of matrix metalloproteinases in human cancer cells by exogenous factors.

Author

Sanchezsweatman O, Soares F, Whaley M, Khokha R, Orr F, and Singh G

Abstract

Matrix degradation by cancer cells is an important attribute of malignant behaviour. We have postulated that during invasion and metastasis, matrix metalloproteinase (MMP) production by cancer cells is modulated by microenvironmental factors. To determine this, we screened human cancer cell lines of diverse histogenesis for their secreted MMP profile following exposure to a diversity of soluble and insoluble agents. Enzymatic changes were observed in the presence of phorbol ester (TPA) and hydrogen peroxide (H2O2). More specifically, we observed: (a) increased secretion and/or activation of gelatinases A (MMP-2) and B (MMP-9) after exposure of 8 cell lines to 10(-6) M TPA; (b) increased activation of interstitial collagenase (MMP-1) caseinolysis after stimulation of 3 cancer cell lines with 10(-7) M TPA; and (c) increased activation of MMP-2 after exposure of 2 cell lines to 0.5 mM H3O2. In functional assays, exposure of lung Calu-6 carcinoma cells to 0.5 mM H2O2 and PC-3 cells to TPA, increased their ability to degrade radiolabelled endothelial cell-derived and osteoblast-like-derived basement membranes, respectively. RNA hybridization studies confirmed and further documented these observations. We conclude that modulation of MMP activity in human cancer cells is a common phenomenon regardless of lineage. Modulatory mechanisms such as increased de novo pro-enzyme synthesis and/or release, and enhanced proenzyme activation may be involved. Furthermore, our results provide evidence that extracellular matrix degradation by human cancer cells during invasion and metastasis may be stimulated by soluble matrix-derived factors in a cell type-specific fashion.

Published
1997
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32. Comparative in vivo and in vitro proliferation of murine tumor cells in the bone microenvironment.

Author

Sanchezsweatman O, Orr F, and Singh G

Abstract

To examine the effect of bone microenvironmental factors on the growth of metastatic cells, the in vivo proliferative features of three murine cell lines were determined at skeletal metastatic sites and correlated with their ability to grow in vitro in the presence of bone-derived factors. Bones, ovaries, adrenals and the brain were most affected by metastasis, following an intraarterial injection of B16/F1 and B16/F10 melanoma and FS/L10 fibrosarcoma cells into C57BL/6 mice. Melanoma cells showed a marked metastatic preference for bone, while fibrosarcoma cells developed brain metastasis in all animals. Tumor burden in bones was highest (19+/-2%) for B16/F10 cells, compared to B16/F1 (10+/-2%) or FS/L10 (3+/-1%) cells. Autoradiographic studies demonstrated organ- and cell type-specific differences in tumor cell proliferation, with B16/F10 cells displaying the lowest labelling indexes in bone (12+/-2% for B16/F10 vs 28+/-2% and 27+/-4% for B16/F1 and FS/L10 cells, respectively). To test if bone-derived factors differentially affected tumor cell growth in these three cell lines H-3-thymidine uptake by these tumor cells was assessed after in vitro incubation with bone-derived conditioned medium. Under these conditions, we observed stimulation of B16/F10 cell proliferation, but inhibition of uptake in the other two cell lines. Thus, these results demonstrate that, in this in vivo experimental model, growth properties of metastatic cells are organ- and cell type-specific. Additionally, we show that the in vitro proliferative behavior of tumor cells in the presence of bone-derived factors correlates and may predict skeletal tumor growth properties in vivo.

Published
1996
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33. Multiple effects on drug-sensitivity, genome stability and malignant potential by combinations of h-ras, C-myc and mutant p53 gene overexpression.

Author

Huang A, Jin H, Taylor W, and Wright J

Abstract

Activation of specific oncogenes and inactivation of tumor suppressor genes play major roles in mechanisms leading to neoplastic transformation. The potential involvement of these genes in determining genome stability is an important issue. To examine the relationships between altered oncogene expression and the effects on genome stability, we have investigated the drug sensitivity properties of mouse 10T1/2 fibroblasts transfected with combinations of H-ras, c-myc and the proline 193 mutant form of p53. The relative colony forming efficiencies of these cells were investigated in the absence or presence of various concentrations of the chemotherapeutic agents, methotrexate, N-(phosphonacetyl)-L-aspartate (PALA) or hydroxyurea. The effects of altered oncogene expression were found to be drug and locus specific, and to lead to increased drug resistance (e.g. H-ras transfectants were significantly resistant to methotrexate or PALA), decreased drug resistance (e.g. H-ras/-myc transfectants were significantly less resistant to PALA or hydroxyurea than H-ras transfected cells), or to no significant change in drug sensitivity (e.g. H-ras transfected cells were not significantly different in sensitivity to hydroxyurea than non-transfected cells). Gene amplification was an important but not the only mechanism for drug resistance. Cells that were transfected with p53 (H-ras/p53 or H-ras/c-myc/p53) exhibited the greatest drug resistance properties with all three chemotherapeutic agents, in keeping with the important role of p53 in DNA repair and DNA amplification mechanisms. Although both H-ras/p53 and H-ras/c-myc/p53 groups exhibited very similar genome stability characteristics as determined by drug sensitivity results, they were significantly different in their abilities to produce transformed foci in vitro and lung metastases in vivo. The H-ras/c-myc/p53 transfected cells formed significantly higher numbers of transformed foci and exhibited a greater malignant potential. These results are consistent with observations that H-ras expression directly correlates with malignant potential, and that H-ras/c-myc/p53 transfected cells have higher H-ras expression than H-ras/p53 transfected cells. Alterations in genomic integrity through changes in onocogene expression play important roles in mechanisms determining drug sensitivity; in addition to genome destabilization, other events are critically involved in regulating transformed and malignant characteristics.

Published
1995
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34. 1-o-octadecyl-2-o-methyl-glycerophosphoscholine inhibits the adhesion of ras-transformed fibroblasts to human endothelial-cells.

Author

Samadder P, Lu X, and Arthur G

Abstract

The adhesion of tumor cells to the endothelium is a key step in haematogenic metastasis. Because alkyllysophospholipids decrease tumor metastasis, we investigated the effect of 1-O-octadecyl-2-O-methyl-glycerophosphocholine (ET18-OCH3) on the adhesion of two highly metastatic ras-transformed 10T1/2 cell lines, CIRAS-2 and CIRAS-3, to confluent endothelial cells. The order of adhesion to the endothelial cells was CIRAS-2 > 10T1/2 > CIRAS-3. RGD peptides were unable to inhibit the binding of the cells suggesting that adhesion was not mediated by fibronectin or vitronectin. Treatment of the cell lines with 20 mu M ET18-OCH3 for 24 h decreased the adhesion of CIRAS-2, CIRAS-3 and 10T1/2 to the endothelial cells by 50, 43 and 36% respectively. Thus interference in the adhesion of tumor cells to the endothelium could contribute to decreased metastasis.

Published
1995
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35. The alpha-anomers and Beta-anomers of 1-o-hexadecyl-2-o-methyl-3-s-thioglucosyl-sn-glycerol inhibit the proliferation of epithelial cancer cell-lines.

Author

Lu X, Rengan K, Bittman R, and Arthur G

Abstract

Previous studies have shown that the alpha anomer of 1-O-hexadecyl-2-O-methyl-3-S-(D-1'-thioglucopyranosyl-sn-glycerol) inhibits the proliferation of leukaemic cell lines while the beta anomer was without any effect. In the present study both the alpha and beta anomers inhibited the proliferation of MCF-7, A427, A549 and T84 cells in a dose dependent manner. These results suggest that the mechanism of action of the ether thioglycolipids in epithelial and leukemic cells may be different. Our studies also revealed that A549, which was the most resilient of the four cell lines to the inhibitory effects of 1-O-alkyl-2-O-methyl-glycerophosphocholine (ET18-OCH3), was the most susceptible to the effects of the ether thioglycolipids. Hence the mechanisms of action of the thioglycolipids appear to be distinct from those of ET18-OCH3. The above ether-linked thioglycolipids may therefore be prototypes of a new class of antitumour ether lipids.

Published
1994
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