92 results on '"Ueda U"'
Search Results
2. Supersonic jet formation and propagation in x-pinches
- Author
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Haas, D. M., Bott, S. C., Kim, J., Mariscal, D. A., Madden, R. E., Eshaq, Y., Ueda, U., Collins IV, G., Gunasekera, K., Beg, F. N., Chittenden, J. P., Niasse, N., and Jennings, C. A.
- Published
- 2011
- Full Text
- View/download PDF
3. A case of gastric duplication cyst with aberrant pancreas
- Author
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Ueda, U., Taketazu, M., Itoh, S., Azuma, H., and Oshima, H.
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- 1991
- Full Text
- View/download PDF
4. Evaluation of Grid Stabilization Control and Various Kinds of PV Modules and Their Systems in Hokuto Mega-Solar System
- Author
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Konishi, H., Kudou, M., Miyata, H., and Ueda, U.
- Subjects
Large PV Power Plants and Distributed PV: System Aspects and Grid Connection ,PV Systems - Abstract
27th European Photovoltaic Solar Energy Conference and Exhibition; 4050-4054, 27 kinds of PV modules and 2 PV tracking systems have been evaluated for constructing future large scale solar systems. A large-scale power conditioning system (LS-PCS) with grid stabilization controls have also developed to connect to the existing extra high voltage grid. Five-year’s verification test was finished successfully in March, 2011. The verification test results of grid stabilization systems, the evaluation test results on PV module characteristics and their systems, and EMC noise generated from the LS-PCS in Hokuto mega-solar system were discussed in this paper.
- Published
- 2012
- Full Text
- View/download PDF
5. TU‐C‐141‐09: An Automated Workflow for Patient‐Specific Verification of Deformable Image Registration
- Author
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Kirby, N, primary, Morin, O, additional, Ueda, U, additional, Nie, K, additional, Chen, J, additional, and Pouliot, J, additional
- Published
- 2013
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6. SU‐E‐J‐94: Investigating the Use of Deformable Algorithms to Register MR Images Acquired with and Without an Endo‐Rectal Coil
- Author
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Ueda, U, primary, Chen, J, additional, Hsu, I, additional, Reed, G, additional, and Pouliot, J, additional
- Published
- 2012
- Full Text
- View/download PDF
7. SU‐E‐J‐84: Investigating the Use of Deformable Algorithms to Register and Accumulate Dose to the Spinal Cord for Head‐And‐Neck Radiotherapy Patients
- Author
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Ueda, U, primary, Chen, J, additional, Kirby, N, additional, Quivey, J, additional, Yom, S, additional, and Pouliot, J, additional
- Published
- 2012
- Full Text
- View/download PDF
8. Use of fluorine-doped silicon oxide for temperature compensation of radio frequency surface acoustic wave devices
- Author
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Matsuda, S., primary, Hara, M., additional, Miura, M., additional, Matsuda, T., additional, Ueda, U. M., additional, Satoh, Y., additional, and Hashimoto, K., additional
- Published
- 2012
- Full Text
- View/download PDF
9. SU-E-J-38: Tracking Changes in Head-and-Neck Rotation and Flexion Using Megavoltage Cone-Beam CT and Deformable Image Registration
- Author
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Chen, J, primary, Yom, S, additional, Ueda, U, additional, Quivey, J, additional, Aubin, M, additional, and Pouliot, J, additional
- Published
- 2011
- Full Text
- View/download PDF
10. 250 kA compact linear transformer driver for wire arrayz-pinch loads
- Author
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Bott, S. C., primary, Haas, D. M., additional, Madden, R. E., additional, Ueda, U., additional, Eshaq, Y., additional, Collins, G., additional, Gunasekera, K., additional, Mariscal, D., additional, Peebles, J., additional, Beg, F. N., additional, Mazarakis, M., additional, Struve, K., additional, and Sharpe, R., additional
- Published
- 2011
- Full Text
- View/download PDF
11. SU‐DD‐A3‐02: The Impact of Cone‐Beam Computed Tomography (CBCT) Artifacts on Deformable Image Registration Algorithms
- Author
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Ueda, U, primary, Hu, W, additional, Pouliot, J, additional, Yom, S, additional, Quivey, J, additional, Aubin, M, additional, and Chen, J, additional
- Published
- 2010
- Full Text
- View/download PDF
12. Study of the effect of current rise time on the formation of the precursor column in cylindrical wire array Z pinches at 1 MA
- Author
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Bott, S. C., primary, Haas, D. M., additional, Eshaq, Y., additional, Ueda, U., additional, Beg, F. N., additional, Hammer, D. A., additional, Kusse, B., additional, Greenly, J., additional, Shelkovenko, T. A., additional, Pikuz, S. A., additional, Blesener, I. C., additional, McBride, R. D., additional, Douglass, J. D., additional, Bell, K., additional, Knapp, P., additional, Chittenden, J. P., additional, Lebedev, S. V., additional, Bland, S. N., additional, Hall, G. N., additional, Suzuki Vidal, F. A., additional, Marocchino, A., additional, Harvey-Thomson, A., additional, Haines, M. G., additional, Palmer, J. B. A., additional, Esaulov, A., additional, and Ampleford, D. J., additional
- Published
- 2009
- Full Text
- View/download PDF
13. Effect of Current Rise-time on the Formation of Precursor Structures and Mass Ablation Rate in Cylindrical Wire Array Z-Pinches
- Author
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Bott, S. C., primary, Haas, D. M., additional, Eshaq, Y., additional, Ueda, U., additional, Beg, F. N., additional, Hammer, D. A., additional, Kusse, B., additional, Greenly, J., additional, Shelkovenko, T. A., additional, Pikuz, S. A., additional, Blesener, I. C., additional, McBride, R. D., additional, Douglass, J. D., additional, Bell, K., additional, Knapp, P., additional, Chittenden, J. P., additional, Lebedev, S. V., additional, Bland, S. N., additional, Hall, G. N., additional, Suzuki, F. A., additional, Marocchino, A., additional, Harvey-Thomson, A., additional, Ampleford, D. J., additional, Kusse, Bruce R., additional, and Hammer, David A., additional
- Published
- 2009
- Full Text
- View/download PDF
14. Cross-point coronal plasma dynamics in two- and four-wire x-pinches
- Author
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Madden, R. E., primary, Bott, S. C., additional, Haas, D., additional, Eshaq, Y., additional, Ueda, U., additional, Collins, G., additional, and Beg, F. N., additional
- Published
- 2008
- Full Text
- View/download PDF
15. Quantitative Measurements of Wire Ablation in Tungsten $X$-pinches at 80 kA
- Author
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Bott, S.C., primary, Haas, D.M., additional, Eshaq, Y., additional, Ueda, U., additional, Lebedev, S.V., additional, Chittenden, J.P., additional, Palmer, J., additional, Bland, S.N., additional, Hall, G.N., additional, Ampleford, D.J., additional, and Beg, F.N., additional
- Published
- 2008
- Full Text
- View/download PDF
16. High-Resolution Laser Schlieren Imaging of Coronal Plasma Evolution in 80-kA $X$-Pinches
- Author
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Bott, S.C., primary, Haas, D.M., additional, Ueda, U., additional, Eshaq, Y., additional, Madden, R., additional, Collins, G., additional, and Beg, F.N., additional
- Published
- 2008
- Full Text
- View/download PDF
17. A low inductance linear transformer driver for exploding wire experiments
- Author
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Bott, S. C., primary, Haas, D. M., additional, Ueda, U., additional, Eshaq, Y., additional, Madden, R., additional, Collins, G., additional, and Beg, F. N., additional
- Published
- 2008
- Full Text
- View/download PDF
18. A dynamical study of gap formation in x-pinch plasmas at 80 kA
- Author
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Madden, R., primary, Bott, S. C., additional, Haas, D. M., additional, Ueda, U., additional, Eshaq, Y., additional, Collins, G., additional, and Beg, F. N., additional
- Published
- 2008
- Full Text
- View/download PDF
19. Dynamics of low density coronal plasma in low current x-pinches
- Author
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Haas, D, primary, Bott, S C, additional, Vikhrev, V, additional, Eshaq, Y, additional, Ueda, U, additional, Zhang, T, additional, Baranova, E, additional, Krasheninnikov, S I, additional, and Beg, F N, additional
- Published
- 2007
- Full Text
- View/download PDF
20. Mass Density Profile Evolution from Wires in X-Pinch and Wire Array Configurations
- Author
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Bott, S.C., primary, Haas, D., additional, Eshaq, Y., additional, Ueda, U., additional, Beg, F.N., additional, Chittenden, J.P., additional, Lebedev, S.V., additional, Bland, S.N., additional, Hall, G.N., additional, Vidal, F.A Suzuki, additional, Marocchino, A., additional, Harvey-Thomson, A., additional, Palmer, J.B.A., additional, Jennings, C.A., additional, Ampleford, D.J., additional, and Ciardi, A., additional
- Published
- 2007
- Full Text
- View/download PDF
21. Time resolved x-ray plasma emission in low current x-pinches
- Author
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Haas, D., primary, Bott, S.C., additional, Ueda, U., additional, Eshaq, Y., additional, and Beg, F. N., additional
- Published
- 2007
- Full Text
- View/download PDF
22. Expression of vascular endothelial growth factor and its receptors (Flt-1, KDR/Flk-1) in the liver metastasis of human colo-rectal cancer
- Author
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Maki, A., primary, Kojima, A., additional, Ueda, U., additional, Matsui-Yuasa, I., additional, Kaneda, K., additional, and Takabayashi, A., additional
- Published
- 1998
- Full Text
- View/download PDF
23. Leucostegia truncata
- Author
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M. Kato, M. Ueda, & U. W. Mahjar, M. Kato, M. Ueda, & U. W. Mahjar, M. Kato, M. Ueda, & U. W. Mahjar, and M. Kato, M. Ueda, & U. W. Mahjar
- Abstract
Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1460556%5DMICH-V-1460556, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1460556/MICH-V-1460556/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
- Published
- 1983
24. Leucostegia pallida
- Author
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K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, and K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar
- Abstract
Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1460536%5DMICH-V-1460536, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1460536/MICH-V-1460536/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
- Published
- 1983
25. Orthiopteris campylura var. kingii
- Author
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K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, and K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar
- Abstract
Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1582231%5DMICH-V-1582231, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1582231/MICH-V-1582231/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
- Published
- 1983
26. Cystodium sorbifolium
- Author
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K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, and K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar
- Abstract
Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1582344%5DMICH-V-1582344, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1582344/MICH-V-1582344/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
- Published
- 1983
27. Orthiopteris campylura var. kingii
- Author
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M. Kato, K. Ueda, & U. W. Mahjar, M. Kato, K. Ueda, & U. W. Mahjar, M. Kato, K. Ueda, & U. W. Mahjar, and M. Kato, K. Ueda, & U. W. Mahjar
- Abstract
Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1582233%5DMICH-V-1582233, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1582233/MICH-V-1582233/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
- Published
- 1983
28. Pteris ensiformis
- Author
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K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar, and K. Iwatsuki, M. Kato, K. Ueda, & U. W. Mahjar
- Abstract
Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1598472%5DMICH-V-1598472, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1598472/MICH-V-1598472/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
- Published
- 1983
29. Pteris mertensioides
- Author
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M. Kato, K. Ueda, & U. W. Mahjar, M. Kato, K. Ueda, & U. W. Mahjar, M. Kato, K. Ueda, & U. W. Mahjar, and M. Kato, K. Ueda, & U. W. Mahjar
- Abstract
Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1597523%5DMICH-V-1597523, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1597523/MICH-V-1597523/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
- Published
- 1983
30. Acystopteris tenuisecta
- Author
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M. Kato, K. Ueda, & U. W. Mahjar, M. Kato, K. Ueda, & U. W. Mahjar, M. Kato, K. Ueda, & U. W. Mahjar, and M. Kato, K. Ueda, & U. W. Mahjar
- Abstract
Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1601063%5DMICH-V-1601063, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1601063/MICH-V-1601063/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
- Published
- 1983
31. Dennstaedtia indet
- Author
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M. Kato, K. Ueda, & U. W. Mahjar, M. Kato, K. Ueda, & U. W. Mahjar, M. Kato, K. Ueda, & U. W. Mahjar, and M. Kato, K. Ueda, & U. W. Mahjar
- Abstract
Pteridophytes, http://name.umdl.umich.edu/IC-HERB00IC-X-1599929%5DMICH-V-1599929, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1599929/MICH-V-1599929/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy
- Published
- 1983
32. (59-60)Synthesis of Vinyl Compounds by Quelet's Reaction
- Author
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Ueda, U., primary and Oda, R., additional
- Published
- 1945
- Full Text
- View/download PDF
33. Time Resolved X-ray Plasma Emission in low Current X-Pinches.
- Author
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Haas, D., Bott, S.C., Ueda, U., Eshaq, Y., and Beg, F.N.
- Published
- 2007
- Full Text
- View/download PDF
34. Dosimetric comparison of five different radiotherapy treatment planning approaches for locally advanced non-small cell lung cancer with sequential plan changes.
- Author
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Saito M, Komiyama T, Marino K, Aoki S, Akita T, Matsuda M, Sano N, Suzuki H, Koji U, Nemoto H, and Onishi H
- Subjects
- Humans, Radiotherapy Planning, Computer-Assisted methods, Radiotherapy Dosage, Carcinoma, Non-Small-Cell Lung radiotherapy, Carcinoma, Non-Small-Cell Lung etiology, Lung Neoplasms radiotherapy, Lung Neoplasms etiology, Radiotherapy, Conformal methods
- Abstract
Background: The purpose of this study was to compare the dosimetric characteristics of five different treatment planning techniques for locally advanced non-small cell lung cancer (LA-NSCLC) with sequential plan changes., Methods: A total of 13 stage III NSCLC patients were enrolled in this study. These patients had both computed tomography (CT) images for initial and boost treatment plans. The latter CT images were taken if tumor shrinkage was observed after 2 weeks of treatment. The prescription dose was 60 Gy/30 Fr (initial: 40 Gy/20 Fr, and boost: 20 Gy/10 Fr). Five techniques (forward-planed 3-dimensional conformal radiotherapy [F-3DCRT] on both CT images, inverse-planned 3DCRT [I-3DCRT] on both CT images, volumetric modulated arc therapy [VMAT] on both CT images, F-3DCRT on initial CT plus VMAT on boost CT [bVMAT], and hybrid of fixed intensity-modulated radiotherapy [IMRT] beams and VMAT beams on both CT images [hybrid]) were recalculated for all patients. The accumulated doses between initial and boost plans were compared among all treatment techniques., Results: The conformity indexes (CI) of the planning target volume (PTV) of the five planning techniques were 0.34 ± 0.10, 0.57 ± 0.10, 0.86 ± 0.08, 0.61 ± 0.12, and 0.83 ± 0.11 for F-3DCRT, I-3DCRT, VMAT, bVMAT, and hybrid, respectively. In the same manner, lung volumes receiving >20 Gy (V
20Gy ) were 21.05 ± 10.56%, 20.86 ± 6.45, 19.50 ± 7.38%, 19.98 ± 10.04%, and 17.74 ± 7.86%. There was significant improvement about CI and V20Gy for hybrid compared with F-3DCRT (p < 0.05)., Conclusion: The IMRT/VMAT hybrid technique for LA-NSCLC patients improved target CI and reduced lung doses. Furthermore, if IMRT was not available initially, starting with 3DCRT might be beneficial as demonstrated in the bVMAT procedure of this study., (© 2023 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)- Published
- 2023
- Full Text
- View/download PDF
35. IgG4-Related Membranous Nephropathy with Acute Nephrotic Syndrome During Successful Steroid Maintenance Treatment for Type 1 Autoimmune Pancreatitis.
- Author
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Ito H, Ashida K, Demiya M, Motomura S, Nagayama A, Kubo S, Ueda U, Fukami K, Nomura M, and Akashi T
- Subjects
- Humans, Male, Cyclosporine, Steroids, Methylprednisolone therapeutic use, Proteinuria, Acute Disease, Insulin, Nephrotic Syndrome complications, Nephrotic Syndrome drug therapy, Autoimmune Pancreatitis, Glomerulonephritis, Membranous complications, Glomerulonephritis, Membranous drug therapy, Immunoglobulin G4-Related Disease complications, Immunoglobulin G4-Related Disease diagnosis, Immunoglobulin G4-Related Disease drug therapy
- Abstract
BACKGROUND Immunoglobulin G4 (IgG4)-related diseases (IgG4-RD) are systemic fibroinflammatory diseases that can develop asynchronously in multiple organs. IgG4-related kidney disease (IgG4-RKD) is generally characterized by tubulointerstitial nephritis but can also manifest as membranous nephropathy without tubulointerstitial nephritis. IgG4-related membranous nephropathy can present as a phenotype of systemic disorders, including autoimmune pancreatitis-associated diabetes mellitus; however, its clinical features remain unclear. CASE REPORT A 56-year-old Japanese man presented to our university hospital with bilateral edema of his lower legs. He had received a diagnosis of type 1 autoimmune pancreatitis and associated diabetes mellitus 16 months prior. He was successfully treated with oral glucocorticoids 25 mg/day of prednisolone as an initial dose, followed by titration down to a maintenance dose (5 mg/day), without recurrence of autoimmune pancreatitis. The pancreas showed atrophy and required basal-bolus insulin therapy owing to insulin insufficiency. Massive proteinuria and hypoalbuminemia with nephrotic syndrome on examination led to a renal biopsy to investigate the etiology and diagnosis of IgG4-RKD. Methylprednisolone and cyclosporine A were successfully administered to ameliorate the proteinuria and control systemic IgG4-RD with IgG4-related membranous nephropathy. CONCLUSIONS Ig4-RKD occurred despite maintenance treatment with prednisolone monotherapy and was controlled with methylprednisolone and cyclosporine A. Measurement of clinical parameters, including proteinuria, was important, and a renal biopsy finally established the diagnosis of IgG4-RKD. IgG4-RKD can present with progressive glomerular lesions and can be latent in cases diagnosed with diabetic kidney disease, particularly in patients with insulin insufficiency.
- Published
- 2023
- Full Text
- View/download PDF
36. Incidence and Mechanism of Refractory Postoperative Cholangitis After Hepatectomy with Hepaticojejunostomy.
- Author
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Koichiro M, Hiroki U, Daisuke A, Yoshiiya I, Shuichi W, Keiichi A, Hiroaki O, Masanori K, Ryuichi O, Shinji T, and Minoru T
- Subjects
- Humans, Incidence, Retrospective Studies, Quality of Life, Neoplasm Recurrence, Local etiology, Postoperative Complications epidemiology, Postoperative Complications etiology, Hepatectomy adverse effects, Cholangitis epidemiology, Cholangitis etiology
- Abstract
Introduction: Malignant tumors, such as hilar cholangiocarcinoma, have shown improved long-term outcomes, and measures to prevent late postoperative complications are important. Postoperative cholangitis after hepatectomy with hepaticojejunostomy (HHJ) may occur and can significantly decrease the quality of life. However, there are few reports on the incidence and pathogenesis of postoperative cholangitis after HHJ., Methods: We retrospectively reviewed 71 cases post HHJ at Tokyo Medical and Dental University Hospital from January 2010 to December 2021. Cholangitis was diagnosed using the Tokyo Guideline 2018. Cases due to tumor recurrence around the hepaticojejunostomy (HJ) were excluded. Patients with three or more episodes of cholangitis were classified as the "refractory cholangitis group" (RC group). RC group patients were divided into a "stenosis group" and "non-stenosis group" according to intrahepatic bile duct dilatation at the onset of cholangitis. Their clinical characteristics and risk factors were analyzed., Results: Cholangitis occurred in 20 patients (28.1%), with 17 (23.9%) in the RC group. Most patients in the RC group developed their first episode within the first postoperative year. The stenosis group consisted of 6 patients, and their cholangitis was treated with repeated anastomotic dilatation and stent replacement. In the non-stenosis group, cholangitis was relatively mild and treated with antibiotics. Hepatobiliary scintigraphy for these cases showed bile congestion in the jejunum near the site of the hepaticojejunostomy., Conclusion: There are two types of postoperative cholangitis, each with different pathogenesis and treatment. It is essential to assess anastomotic stenosis early and provide the necessary treatment., (© 2023. The Society for Surgery of the Alimentary Tract.)
- Published
- 2023
- Full Text
- View/download PDF
37. Evaluation of fMRI activation in hemiparetic stroke patients after rehabilitation with low-frequency repetitive transcranial magnetic stimulation and intensive occupational therapy.
- Author
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Wanni Arachchige PR, Ryo U, Karunarathna S, and Senoo A
- Subjects
- Humans, Transcranial Magnetic Stimulation methods, Magnetic Resonance Imaging, Upper Extremity, Magnetic Resonance Spectroscopy, Recovery of Function, Treatment Outcome, Occupational Therapy, Stroke complications, Stroke diagnostic imaging, Stroke therapy, Stroke Rehabilitation methods
- Abstract
Purpose: To evaluate activity changes associated with the intervention of low-frequency repetitive transcranial magnetic stimulation (rTMS) and intensive occupational therapy (OT) after stroke using functional magnetic resonance (fMRI). Methods: Seventy stroke patients were scanned while performing finger tapping tasks twice, before and 12 days after the intervention. Recovery of motor functions assessed using Fugl-Meyer Assessment (FMA) and Wolf Motor Function Test-Functional Ability Scale (WMFT-FAS) for upper extremity at each time point. An fMRI analysis was performed, and a region of interest (ROI) analysis was conducted using percentage signal changes (% SC) to determine the magnitude of activation. Results: FMA and WMFT-FAS were significantly increased from pre-intervention to post-intervention. Intervention related activations were seen in the ipsilesional premotor cortex (PMC) and primary motor cortex (M1), thalamo-cortico regions with the paretic hand movements. With the unaffected hand movements, significant clusters in the contralesional primary somatosensory cortex (S1), superior parietal cortex, and bilateral cerebellum were observed. The ROI-based analysis revealed that ipsilesional M1, contralesional PMC, and supplementary motor area (SMA) showed significantly higher results with the paretic hand movements, a trend toward a significant decrease in the contralesional S1 with the unaffected hand movements from the pre-intervention to post-intervention. Conclusions: Our findings suggest that gains in motor functions produced by the intervention of rTMS and intensive OT in hemiparesis stroke patients may be associated with the ipsilesional hemisphere and contralesional hemisphere as well. Identifying rTMS and OT intervention based on cortical patterns may help to implement rTMS in motor rehabilitation after stroke.Supplementary data for this article is available online at https://doi.org/10.1080/00207454.2021.1968858 .
- Published
- 2023
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38. The Outcome of Neurorehabilitation Efficacy and Management of Traumatic Brain Injury.
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Akira M, Yuichi T, Tomotaka U, Takaaki K, Kenichi M, and Chimi M
- Abstract
For public health professionals, traumatic brain injury (TBI) and its possible protracted repercussions are a significant source of worry. In opposed to patient neurorehabilitation with developed brain abnormalities of different etiologies, neurorehabilitation of affected persons has several distinct features. The clinical repercussions of the various types of TBI injuries will be discussed in detail in this paper. During severe TBI, the medical course frequently follows a familiar first sequence of coma, accompanied by disordered awareness, followed by agitation and forgetfulness, followed by return of function. Clinicians must be aware of common medical issues that might occur throughout the various stages of neurorehabilitation, for example, posttraumatic hydrocephalus, paroxysmal sympathetic hyperactivity and posttraumatic neuroendocrine disorders, at each step of the process. Furthermore, we address problems about the scheduling of various rehabilitation programs as well as the availability of current data for comprehensive rehabilitative neuropsychology techniques., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Akira, Yuichi, Tomotaka, Takaaki, Kenichi and Chimi.)
- Published
- 2022
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39. Changes in brain morphometry after motor rehabilitation in chronic stroke.
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Arachchige PRW, Karunarathna S, Wataru U, Ryo U, Median AC, Yao DP, Abo M, and Senoo A
- Subjects
- Brain diagnostic imaging, Humans, Recovery of Function, Transcranial Magnetic Stimulation, Motor Cortex, Stroke, Stroke Rehabilitation
- Abstract
Purpose: Recent studies have revealed structural changes after motor rehabilitation, but its morphological changes related to upper limb motor behaviours have not been studied exhaustively. Therefore, we aimed to map the grey matter (GM) changes associated with motor rehabilitation after stroke using voxel-based morphometry (VBM), deformation-based morphometry (DBM), and surface-based morphometry (SBM)., Methods: Forty-one patients with chronic stroke received twelve sessions of low-frequency repetitive transcranial magnetic stimulation plus intensive occupational therapy. MRI data were obtained before and after the intervention. Fugl-Meyer Assessment and Wolf Motor Function Test-Functional Ability Scale were assessed at the two-time points. We performed VBM, DBM, and SBM analyses using T1-weighted images. A correlation analysis was performed between cortical thickness in motor areas and clinical outcomes., Results: Clinical outcomes significantly improved after the intervention. VBM showed significant GM volume changes in ipsilesional and contralesional primary motor regions. DBM results demonstrated GM changes contralesionally and ipsilesionally after the intervention. SBM results showed significant cortical thickness changes in posterior visuomotor coordination, precentral, postcentral gyri of the ipsilesional hemisphere and contralesional visuomotor area after the intervention. A combination of threshold p < .05, False Discovery Rate and p < .001 (uncorrected) were considered significant. In addition, cortical thickness changes of the ipsilesional motor areas were significantly correlated with the clinical outcome changes., Conclusions: We found GM structural changes in areas involved in motor, visuomotor and somatosensory functions after the intervention. Furthermore, our findings suggest that structural plasticity changes in chronic stroke could occur in the ipsilesional and contralesional hemispheres after motor rehabilitation.
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- 2021
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40. Prediction of disability-adjusted life years for diseases due to low fruit intake in 2017-2040 in Japan.
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Yoneoka D, Nomura S, Tanaka S, Ishizuka A, Peter U, Rauniyar SK, Nakamura K, Uneyama H, Hayashi N, and Shibuya K
- Subjects
- Adult, Fruit, Humans, Japan epidemiology, Nutrition Surveys, Quality-Adjusted Life Years, Young Adult, Cardiovascular Diseases epidemiology, Disabled Persons
- Abstract
Objective: The current study aimed to predict disability-adjusted life years (DALY) rate in Japan through 2040 with plausible future scenarios of fruit intake for neoplasms, cardiovascular diseases (CVD) and diabetes and kidney diseases (DKD)., Design: Data from National Health and Nutrition Surveys and the Global Burden of Diseases study in 2017 were used. We developed an autoregressive integrated moving average model with four future scenarios. Reference scenario maintains the current trend. Best scenario assumes that the goal defined in Health Japan 21 is achieved in 2023 and is kept constant afterwards. Moderate scenario assumes that the goal is achieved in 2040. Constant scenario applies the same proportion of 2016 for the period between 2017 and 2040., Setting: DALY rates in Japan were predicted for the period between 2017 and 2040., Participants: Population aged more than than 20 years old., Results: In our reference forecast, the DALY rates in all-ages group were projected to be stable for CVD and continue increasing for neoplasms and DKD. Age group-specific DALY rates for these three disease groups were forecasted to decrease, with some exceptions. Among men aged 20-49 years, DALY attributable to CVD differed substantially between the scenarios, implying that there is a significant potential for reducing the burden of CVD by increasing fruit intake at the population level., Conclusions: Our scenario analysis shows that higher fruit intake is associated with lower disease burden in Japan. Further research is required to assess which policies and interventions can be used to achieve an increase in fruit intake as modelled in the scenarios of the current study.
- Published
- 2021
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41. Effect of tolvaptan on renal involvement in patients with autosomal dominant polycystic kidney disease according to different gene mutations.
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Moriyama T, Nakayama Y, Soejima M, Yokota Y, Ota K, Ito S, Kodama G, Nakamura N, Kurokawa Y, Yano J, Ueda U, Takamiya Y, Kaida Y, Hazama T, Shibata R, Koda Y, and Fukami K
- Subjects
- Adult, Aged, Female, Genetic Predisposition to Disease, Glomerular Filtration Rate drug effects, Humans, Kidney diagnostic imaging, Kidney physiopathology, Male, Middle Aged, Polycystic Kidney, Autosomal Dominant diagnosis, Polycystic Kidney, Autosomal Dominant genetics, Polycystic Kidney, Autosomal Dominant physiopathology, Recovery of Function, Retrospective Studies, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Antidiuretic Hormone Receptor Antagonists therapeutic use, Kidney drug effects, Mutation, Polycystic Kidney, Autosomal Dominant drug therapy, TRPP Cation Channels genetics, Tolvaptan therapeutic use
- Abstract
Background: Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder caused by mutations in the polycystic kidney disease (PKD) gene. Although tolvaptan has benefits for renal involvement, the different effects depending on the gene mutation type are unknown. Thus, we explore the different effects of tolvaptan on the annual changes in total kidney volume (%TKV) and estimated glomerular filtration rate (eGFR) according to the gene mutation type in ADPKD patients., Methods: In total, 135 ADPKD patients were screened, and 22 patients taking tolvaptan for at least a year were retrospectively studied at the Kurume University Hospital. We examined the decline in renal function and %TKV by computed tomography and analyzed the gene mutation. Patients were classified into the following four groups according to gene mutation type: PKD1-truncated, PKD1-non-truncated, PKD2, and mutation not found. Patients were treated with tolvaptan, and the effects of tolvaptan were analyzed according to the gene mutation type., Results: Patients (age: 52.3 ± 11.2 years) were administered tolvaptan at a dose of 45 or 60 mg. No variation was observed in the annual changes in eGFR (%eGFR) (before: - 10.5% ± 13.9%, after: - 14.4% ± 8.1%, P = 0.139), whereas %TKV was significantly improved after the tolvaptan treatment (before: 14.9% ± 8.0%, after: - 5.4% ± 7.6%, P < 0.001). Unlike %eGFR, tolvaptan treatment significantly improved %TKV, regardless of the type of gene mutation., Conclusions: A year treatment with tolvaptan significantly improved %TKV in patients with ADPKD, regardless of the gene mutation type.
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- 2021
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42. Strategies for reducing ovarian dose in volumetric modulated arc therapy (VMAT) for postoperative uterine cervical cancer.
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Yoshihiro U, Shingo O, Masaru I, Masayoshi M, Koji K, Shoji K, Iori S, Kazuhiko O, and Teruki T
- Subjects
- Female, Humans, Organs at Risk, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Radiotherapy, Adjuvant, Uterine Cervical Neoplasms surgery, Organ Sparing Treatments, Ovary, Radiotherapy, Intensity-Modulated methods, Uterine Cervical Neoplasms radiotherapy
- Abstract
Objective: To reduce the ovarian dose with volumetric modulated arc therapy (VMAT), an original VMAT was designed with two types of arcs to restrict angles and fields (R-VMAT)., Methods: The subjects were 11 patients who underwent ovarian transposition with clips left by a surgeon. Three methods, intensity-modulated radiotherapy (IMRT), standard VMAT (S-VMAT) and R-VMAT, were optimized for assessment of the ovarian dose with the target coverage kept high., Results: The homogeneity and conformity indexes for the planning target volume (PTV) were similar for the three methods. However, the average ± SD of the ovarian mean dose (OMD) was 5.0 ± 1.5, 4.9 ± 1.9 and 3.5 ± 1.4 Gy, and the percentage of ovarian volume exceeding 5 Gy (V5) was 41.5 ± 34.1%, 34.1 ± 38.05% and 8.4 ± 20.5% for IMRT, S-VMAT and R-VMAT, respectively. The OMD and V5 were significantly smaller for R-VMAT than for the other plans (p < 0.01). Correlation values between the OMD and the lateral distance from the ovaries to the PTV surface were 0.86, 0.81 and 0.82 for IMRT, S-VMAT and R-VMAT, respectively., Conclusion: These findings suggest that R-VMAT delivered the lowest dose to the ovaries. To reduce the OMD to less than 3 Gy, ovaries should be transposed laterally 6.1 cm away from the PTV surface when R-VMAT is used. Advances in knowledge: When organs with high susceptibility to radiation, such as ovaries, are near the PTV, R-VMAT is superior to IMRT and S-VMAT.
- Published
- 2018
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43. Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome.
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Ramachandra Rao S, Pfeffer BA, Más Gómez N, Skelton LA, Keiko U, Sparrow JR, Rowsam AM, Mitchell CH, and Fliesler SJ
- Subjects
- Animals, Biomarkers metabolism, Cathepsin D metabolism, Cattle, Cell Culture Techniques, Dehydrocholesterols metabolism, Disease Models, Animal, Humans, Lysosomes metabolism, Membrane Fusion, Phagocytosis, Protein Biosynthesis, Rats, Retinal Pigment Epithelium metabolism, Retinoids metabolism, Rod Cell Outer Segment metabolism, Smith-Lemli-Opitz Syndrome genetics, Transcription, Genetic, Ubiquitinated Proteins metabolism, trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride, Phagosomes metabolism, Retinal Pigment Epithelium pathology, Smith-Lemli-Opitz Syndrome pathology
- Abstract
Treatment of rats with the cholesterol pathway inhibitor AY9944 produces an animal model of Smith-Lemli-Opitz syndrome (SLOS), an autosomal recessive disease caused by defective cholesterol synthesis. This SLOS rat model undergoes progressive and irreversible degeneration of the neural retina, with associated pathological features of the retinal pigmented epithelium (RPE). Here, we provide further insights into the mechanism involved in the RPE pathology. In the SLOS rat model, markedly increased RPE apical autofluorescence is observed, compared to untreated animals, which correlates with increased levels of A2E and other bisretinoids. Utilizing cultured human induced pluripotent stem cell (iPSC)- derived SLOS RPE cells, we found significantly elevated steady-state levels of 7-dehydrocholesterol (7DHC) and decreased cholesterol levels (key biochemical hallmarks of SLOS). Western blot analysis revealed altered levels of the macroautophagy/autophagy markers MAP1LC3B-II and SQSTM1/p62, and build-up of ubiquitinated proteins. Accumulation of immature autophagosomes was accompanied by inefficient degradation of phagocytized, exogenously supplied retinal rod outer segments (as evidenced by persistence of the C-terminal 1D4 epitope of RHO [rhodopsin]) in SLOS RPE compared to iPSC-derived normal human control. SLOS RPE cells exhibited lysosomal pH levels and CTSD activity within normal physiological limits, thus discounting the involvement of perturbed lysosomal function. Furthermore, 1D4-positive phagosomes that accumulated in the RPE in both pharmacological and genetic rodent models of SLOS failed to fuse with lysosomes. Taken together, these observations suggest that defective phagosome maturation underlies the observed RPE pathology. The potential relevance of these findings to SLOS and the requirement of cholesterol for phagosome maturation are discussed.
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- 2018
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44. Lack of associations between genetic polymorphisms in GSTM1, GSTT1 and GSTP1 and pancreatic cancer risk: a multi-institutional case-control study in Japan.
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Yamada I, Matsuyama M, Ozaka M, Inoue D, Muramatsu Y, Ishii H, Junko U, Ueno M, Egawa N, Nakao H, Mori M, Matsuo K, Nishiyama T, Ohkawa S, Hosono S, Wakai K, Nakamura K, Tamakoshi A, Kuruma S, Nojima M, Takahashi M, Shimada K, Yagyu K, Kikuchi S, and Lin Y
- Subjects
- Aged, Case-Control Studies, Female, Genotype, Humans, Japan, Male, Middle Aged, Pancreatic Neoplasms enzymology, Polymorphism, Genetic, Risk Factors, Smoking adverse effects, Glutathione S-Transferase pi genetics, Glutathione Transferase genetics, Pancreatic Neoplasms genetics
- Abstract
Background: We aimed to evaluate the role of genetic polymorphisms in tobacco carcinogen-metabolizing genes and their interactions with smoking in a hospital-based case-control study of Japanese subjects., Materials and Methods: We examine the associations of pancreatic cancer risk with genetic polymorphisms in GSTM1, GSTT1 and GSTP1, phase II enzymes that catalyze the conjugation of toxic and carcinogenic electrophilic molecules. The study population consisted of 360 patients and 400 control subjects, who were recruited from several medical facilities in Japan. Unconditional logistic regression methods were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and pancreatic cancer risk., Results: Among the control subjects, the prevalence of the GSTM1-null genotype and the GSTT1-null genotype was approximately 56% and 48%, respectively. Cases and controls were comparable in terms of GSTM1 and GSTT1 genotype distributions. Neither of the deleted polymorphisms in GSTM1 and GSTT1 was associated with the risk of pancreatic cancer, with an age- and sex-adjusted OR of 0.99 (95%CI: 0.74-1.32) for the GSTM1-null genotype, and 0.98 (95%CI: 0.73-1.31) for the GSTT1-null genotype. The OR was 0.97 (95%CI: 0.64-1.47) for individuals with the GSTM1 and GSTT1-null genotypes compared with those with the GSTM1 and GSTT1- present genotypes. No synergistic effects of smoking or GST genotypes were observed., Conclusions: Our results indicate no overall association between the GSTM1 and GSTT1 deletion polymorphisms and pancreatic cancer risk in the Japanese subjects in our study.
- Published
- 2014
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45. The need for application-based adaptation of deformable image registration.
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Kirby N, Chuang C, Ueda U, and Pouliot J
- Subjects
- Algorithms, Humans, Imaging, Three-Dimensional, Phantoms, Imaging, Tomography, X-Ray Computed, Urinary Bladder diagnostic imaging, Image Processing, Computer-Assisted methods
- Abstract
Purpose: To utilize a deformable phantom to objectively evaluate the accuracy of 11 different deformable image registration (DIR) algorithms., Methods: The phantom represents an axial plane of the pelvic anatomy. Urethane plastic serves as the bony anatomy and urethane rubber with three levels of Hounsfield units (HU) is used to represent fat and organs, including the prostate. A plastic insert is placed into the phantom to simulate bladder filling. Nonradiopaque markers reside on the phantom surface. Optical camera images of these markers are used to measure the positions and determine the deformation from the bladder insert. Eleven different DIR algorithms are applied to the full and empty-bladder computed tomography images of the phantom (fixed and moving volumes, respectively) to calculate the deformation. The algorithms include those from MIM Software (MIM) and Velocity Medical Solutions (VEL) and nine different implementations from the deformable image registration and adaptive radiotherapy toolbox for Matlab. These algorithms warp one image to make it similar to another, but must utilize a method for regularization to avoid physically unrealistic deformation scenarios. The mean absolute difference (MAD) between the HUs at the marker locations on one image and the calculated location on the other serves as a metric to evaluate the balance between image similarity and regularization. To demonstrate the effect of regularization on registration accuracy, an additional beta version of MIM was created with a variable smoothness factor that controls the emphasis of the algorithm on regularization. The distance to agreement between the measured and calculated marker deformations is used to compare the overall spatial accuracy of the DIR algorithms. This overall spatial accuracy is also utilized to evaluate the phantom geometry and the ability of the phantom soft-tissue heterogeneity to represent patient data. To evaluate the ability of the DIR algorithms to accurately transfer anatomical contours, the rectum is delineated on both the fixed and moving images. A Dice similarity coefficient is then calculated between the contour on the fixed image and that transferred, via the calculated deformation, from the moving to the fixed image., Results: The phantom possesses sufficient soft-tissue heterogeneity to act as a proxy for patient data. Large discrepancies appear between the algorithms and the measured ground-truth deformation. VEL yields the smallest mean spatial error and a Dice coefficient of 0.90. MIM produces the lowest MAD value and the highest Dice coefficient of 0.96, but creates the largest spatial errors. Increasing the MIM smoothness factor above the default value improves the overall spatial accuracy, but the factor associated with the lowest mean error decreases the Dice coefficient to 0.85., Conclusions: Different applications of DIR require disparate balances between image similarity and regularization. A DIR algorithm that is optimized only for its ability to transfer anatomical contours will yield large deformation errors in homogeneous regions, which is problematic for dose mapping. For this reason, these algorithms must be tested for their overall spatial accuracy. The developed phantom is an objective tool for this purpose.
- Published
- 2013
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46. Placebo-controlled, double-blind study of the non-purine-selective xanthine oxidase inhibitor Febuxostat (TMX-67) in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study.
- Author
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Kamatani N, Fujimori S, Hada T, Hosoya T, Kohri K, Nakamura T, Ueda T, Yamamoto T, Yamanaka H, and Matsuzawa Y
- Subjects
- Adult, Central Nervous System Diseases blood, Central Nervous System Diseases complications, Dental Enamel abnormalities, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 complications, Dose-Response Relationship, Drug, Double-Blind Method, Febuxostat, Female, Follow-Up Studies, Gout blood, Gout complications, Gout Suppressants administration & dosage, Humans, Japan, Kidney Diseases, Cystic blood, Kidney Diseases, Cystic complications, Male, Middle Aged, Thiazoles administration & dosage, Treatment Outcome, Xanthine Oxidase blood, Central Nervous System Diseases drug therapy, Diabetes Mellitus, Type 2 drug therapy, Gout drug therapy, Gout Suppressants therapeutic use, Kidney Diseases, Cystic drug therapy, Thiazoles therapeutic use, Uric Acid blood, Xanthine Oxidase antagonists & inhibitors
- Abstract
Background: : Allopurinol has been widely used for treatment of hyperuricemia, however, it may be associated with various adverse effects. Febuxostat has been identified as a potentially safe and efficacious alternative., Objectives: : A multicenter study with randomized, placebo-controlled, double-blind, parallel-group comparison was carried out to evaluate the efficacy and safety of febuxostat in 103 patients with hyperuricemia (including patients with gout) in Japan., Methods: : Subjects were treated with febuxostat (20 or 40 mg/d) or a placebo for 8 weeks. The variables evaluated were the percentage of patients achieving serum uric acid levels 6.0 mg/dL or less and the percent change in serum uric acid levels after 8 weeks., Results: : The percentage of patients achieving serum uric acid levels 6.0 mg/dL or less after 8 weeks was 91.2% in the febuxostat 40-mg/d group, 45.7% in the 20-mg/d group, and 0.0% in the placebo group. The percent changes in serum uric acid levels after 8 weeks were -44.9% in the febuxostat 40-mg/d group, -28.9% in the 20-mg/d group, and -0.6% to -0.5% in the placebo group. No severe or medically significant adverse reaction attributable to febuxostat was noted, and there was no event that could pose a clinical problem. The efficacy did not differ depending on the presence/absence of gout history., Conclusions: : These results suggest that febuxostat (20 or 40 mg/d) is useful as a new means of treating hyperuricemia and is capable of reducing serum uric acid levels to 6.0 mg/dL or less (goal of treatment) with high safety regardless of the presence/absence of gout history.
- Published
- 2011
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47. An allopurinol-controlled, multicenter, randomized, open-label, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 2 exploratory clinical study.
- Author
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Kamatani N, Fujimori S, Hada T, Hosoya T, Kohri K, Nakamura T, Ueda T, Yamamoto T, Yamanaka H, and Matsuzawa Y
- Subjects
- Administration, Oral, Dose-Response Relationship, Drug, Double-Blind Method, Febuxostat, Female, Follow-Up Studies, Gout blood, Gout complications, Humans, Hyperuricemia blood, Hyperuricemia complications, Japan, Male, Middle Aged, Time Factors, Treatment Outcome, Xanthine Oxidase blood, Allopurinol administration & dosage, Gout drug therapy, Gout Suppressants administration & dosage, Hyperuricemia drug therapy, Thiazoles administration & dosage, Uric Acid blood, Xanthine Oxidase antagonists & inhibitors
- Abstract
Background: Allopurinol has been widely used for the treatment of hyperuricemia, however, it may be associated with various adverse effects. Febuxostat has been identified as a potentially safe and efficacious alternative., Objectives: Febuxostat was administered to patients with hyperuricemia including gout in Japan to compare its efficacy and safety with those of allopurinol., Methods: The starting dose of febuxostat and allopurinol was 10 and 100 mg/d, respectively, and was increased to the fixed maintenance dose of 40 or 60 mg/d for febuxostat and 300 mg/d for allopurinol for 16 weeks., Results: : The percent change in the serum uric acid level at 16 weeks compared with the baseline serum uric acid level was -42.96% ± 13.33% and -52.47% ± 9.79% for the febuxostat 40- and 60-mg/d groups, respectively, and -36.55% ± 18.59% for the allopurinol group, indicating that the hypouricemic effects of febuxostat increased in a dose-dependent manner and equaled to or surpassed those of allopurinol (P = 0.0239, 2-sample t test). The percentage of patients with serum uric acid levels of 6.0 mg/dL or less at 16 weeks was 88.9% and 100% for the febuxostat 40- and 60-mg/d groups, respectively, and 68.8% for the allopurinol group, showing higher achievements for the febuxostat groups compared with the allopurinol group. All adverse drug reactions were mild to moderate in severity, and there were no severe symptoms or reactions leading to drug discontinuation., Conclusions: These results suggest that febuxostat is safe at doses of 40 and 60 mg/d and has equal or greater efficacy than 300 mg/d allopurinol.
- Published
- 2011
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48. Placebo-controlled double-blind dose-response study of the non-purine-selective xanthine oxidase inhibitor febuxostat (TMX-67) in patients with hyperuricemia (including gout patients) in japan: late phase 2 clinical study.
- Author
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Kamatani N, Fujimori S, Hada T, Hosoya T, Kohri K, Nakamura T, Ueda T, Yamamoto T, Yamanaka H, and Matsuzawa Y
- Subjects
- Administration, Oral, Dose-Response Relationship, Drug, Double-Blind Method, Febuxostat, Female, Follow-Up Studies, Gout blood, Gout complications, Humans, Hyperuricemia blood, Hyperuricemia complications, Japan, Male, Middle Aged, Treatment Outcome, Gout drug therapy, Gout Suppressants administration & dosage, Hyperuricemia drug therapy, Thiazoles administration & dosage, Uric Acid blood, Xanthine Oxidase antagonists & inhibitors
- Abstract
Background: Allopurinol has been widely used for the treatment of hyperuricemia, however, it may be associated with various adverse effects. Febuxostat has been identified as a potentially safe and efficacious alternative., Objectives: A multicenter study with randomized, placebo-controlled, double-blind, parallel, intergroup comparison was carried out to evaluate the dose-response relationship, efficacy, and safety of febuxostat in 202 patients with hyperuricemia (including patients with gout) in Japan., Methods: The subjects were treated with febuxostat at fixed maintenance doses (20-80 mg/d) or a placebo for 16 weeks. The percentage of patients achieving serum uric acid levels 6.0 mg/dL or less and the percent change in serum uric acid levels after 16 weeks of treatment were evaluated., Results: The percentage of patients achieving serum uric acid levels 6.0 mg/dL or less at 16 weeks was 87.8% in the 80-mg/d dose group, 83.3% in the 60-mg/d group, 82.9% in the 40-mg/d group, 46.5% in the 20-mg/d group, and 2.6% in the placebo group (P < 0.001, Mantel-Haenszel test). A statistically significant dose-response relationship was found. The percent change in serum uric acid levels after 16 weeks of treatment differed significantly between each febuxostat dose group and the placebo group and increased in a dose-dependent manner above 40 mg/d. No deaths, events posing a clinical problem, or serious adverse reactions attributable to febuxostat were noted. Similar results were obtained regardless of gout history., Conclusions: Febuxostat can safely reduce serum uric acid levels to 6.0 mg/dL or less in 80% or more of patients with hyperuricemia (including gout) at doses of 40 mg/d or higher.
- Published
- 2011
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49. A short period of mannitol stress but not LiCl stress led to global translational repression in plants.
- Author
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Matsuura H, Kiyotaka U, Ishibashi Y, Kubo Y, Yamaguchi M, Hirata K, Demura T, and Kato K
- Subjects
- Arabidopsis cytology, Arabidopsis physiology, Cell Line, Lithium Chloride pharmacology, Time Factors, Arabidopsis drug effects, Arabidopsis genetics, Mannitol pharmacology, Protein Biosynthesis drug effects, Stress, Physiological drug effects, Stress, Physiological genetics
- Abstract
In plant cells, high salinity stress induces rapid inhibition of general protein synthesis. In this study, we found that treatment with mannitol, but not lithium stress, led to rapid global translational repression, suggesting that a rapid response at the level of translation might be induced by the osmotic but not the ionic components of salinity stress.
- Published
- 2010
- Full Text
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50. Individual testimonies to nursing care after the atomic bombing of Hiroshima in 1945.
- Author
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Matsunari Y, Nozawa S, Sakata K, Ohara Y, Takahashi K, Hyakuta Y, Ueda M, Ohara R, Kobayashi T, Kawano N, and Mizumoto K
- Subjects
- Humans, Japan, Nurse's Role, Radiation Injuries etiology, Emergency Medical Services organization & administration, Life Change Events, Nuclear Warfare, Nuclear Weapons, Nursing Care organization & administration, Radiation Injuries nursing
- Abstract
Aim: The aim of the present research is to clarify the nursing care conducted just before and after the atomic bombing of Hiroshima in 1945., Methods: Five surviving nurses, who were registered nursing staff at that time in Hiroshima, offered to participate in this research. Individual interviews were conducted in order to obtain the information concerning the nursing activities in the disaster-stricken areas. The collected information was collated with the documents with regard to the atomic bombing in Hiroshima, and compared with the current studies concerning nursing in disaster., Findings: The five nurses who participated in the study made it clear that, from the day of the bombing, nursing care activities changed moment by moment according to the condition of the radiation victims, the stricken areas and the relief systems. Under these circumstances, the nurses tried to help the victims of the bombing by devising anything useful for nursing care., Conclusion: The research participants left their messages, pointing out that nurses' mental attitude to those in front of them as patients is one of the most important things to keep in mind following any major disaster.
- Published
- 2008
- Full Text
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